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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: PTCD3 (NCBI Gene ID:55037)

Gene Summary

Gene Summary

Gene Information	Gene Name: PTCD3
	Gene ID: 55037
	Gene Symbol	PTCD3
	Gene ID	55037
	Gene Name	pentatricopeptide repeat domain 3
	Synonyms	MRP-S39
	Cytomap	2p11.2
	Type of Gene	protein-coding
	Description	pentatricopeptide repeat domain-containing protein 3, mitochondrial28S ribosomal protein S39, mitochondrialTRG-15mitochondrial small ribosomal subunit protein mS39pentatricopeptide repeat-containing protein 3, mitochondrialtransformation-related gene
	Modification date	20200327
	UniProtAcc	Q96EY7

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0032543	Mitochondrial translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
PTCD3	(733 - 1119.25]

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Translation Studies in PubMed

We searched PubMed using 'PTCD3[title] AND translation [title] AND human.'

Gene	Title	PMID
PTCD3	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000254630	86346043	86346167	Frame-shift
ENST00000254630	86348601	86348717	Frame-shift
ENST00000254630	86352577	86352638	Frame-shift
ENST00000254630	86352917	86353003	Frame-shift
ENST00000254630	86355063	86355114	In-frame
ENST00000254630	86357770	86357860	In-frame
ENST00000254630	86360300	86360379	Frame-shift
ENST00000254630	86361961	86362110	Frame-shift
ENST00000254630	86364104	86364263	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000254630	86355063	86355114	6751	1163	1213	689	365	382
ENST00000254630	86357770	86357860	6751	1214	1303	689	382	412
ENST00000254630	86364104	86364263	6751	1887	2045	689	607	659

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q96EY7	607	659	38	689	Chain	ID=PRO_0000305028;Note=Pentatricopeptide repeat domain-containing protein 3%2C mitochondrial
Q96EY7	365	382	38	689	Chain	ID=PRO_0000305028;Note=Pentatricopeptide repeat domain-containing protein 3%2C mitochondrial
Q96EY7	382	412	38	689	Chain	ID=PRO_0000305028;Note=Pentatricopeptide repeat domain-containing protein 3%2C mitochondrial
Q96EY7	365	382	331	367	Repeat	Note=PPR 5
Q96EY7	365	382	368	409	Repeat	Note=PPR 6
Q96EY7	382	412	368	409	Repeat	Note=PPR 6
Q96EY7	382	412	412	446	Repeat	Note=PPR 7
Q96EY7	365	382	1	409	Alternative sequence	ID=VSP_028191;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q96EY7	382	412	1	409	Alternative sequence	ID=VSP_028191;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q96EY7	382	412	410	413	Alternative sequence	ID=VSP_028192;Note=In isoform 2. PDDD->MMAY;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q96EY7	382	412	400	400	Sequence conflict	Note=L->S;Ontology_term=ECO:0000305;evidence=ECO:0000305

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
STAD	PTCD3	-1.34538483750672	0.00256496202200651
READ	PTCD3	2.94667594287193	0.03125
HNSC	PTCD3	1.11617967730562	0.0372559385364731
LUSC	PTCD3	-2.41729475275087	3.25673250216465e-06
THCA	PTCD3	1.09980719703362	4.34082003868401e-07

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
UCEC	PTCD3	hsa-miR-152-3p	86	0.399541634835753	0.0199207279943649

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LGG	PTCD3	-0.082363387	0.005816583
HNSC	PTCD3	-0.085182504	0.019172053

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with PTCD3 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
THYM	CGC	PTCD3	ZCCHC8	0.820741632	5.88E-31
THYM	Epifactor	PTCD3	MBTD1	0.800270779	2.01E-28
THYM	Epifactor	PTCD3	SMARCAD1	0.800286669	2.00E-28
UCS	CGC	PTCD3	ZCCHC8	0.820741632	5.88E-31
UCS	Epifactor	PTCD3	MBTD1	0.800270779	2.01E-28
UCS	Epifactor	PTCD3	SMARCAD1	0.800286669	2.00E-28
UVM	Cell metabolism gene	PTCD3	HMGCR	0.801758645	4.08E-19
UVM	Cell metabolism gene	PTCD3	PITPNB	0.803073737	3.23E-19
UVM	Cell metabolism gene	PTCD3	L2HGDH	0.804800316	2.37E-19
UVM	Cell metabolism gene	PTCD3	GALNT11	0.804981593	2.30E-19
UVM	Cell metabolism gene	PTCD3	BPNT1	0.80596629	1.92E-19
UVM	Cell metabolism gene	PTCD3	ETNK1	0.808585104	1.19E-19
UVM	Cell metabolism gene	PTCD3	SGPP1	0.808727588	1.16E-19
UVM	Cell metabolism gene	PTCD3	NUDT12	0.809493804	1.01E-19
UVM	Cell metabolism gene	PTCD3	NAMPT	0.809852648	9.46E-20
UVM	Cell metabolism gene	PTCD3	MANEA	0.810709644	8.07E-20
UVM	Cell metabolism gene	PTCD3	NUP35	0.810800008	7.94E-20
UVM	Cell metabolism gene	PTCD3	PLA2G12A	0.811989437	6.36E-20
UVM	Cell metabolism gene	PTCD3	PPARA	0.812999795	5.26E-20
UVM	Cell metabolism gene	PTCD3	PMPCB	0.814774368	3.76E-20
UVM	Cell metabolism gene	PTCD3	PPAT	0.815636299	3.19E-20
UVM	Cell metabolism gene	PTCD3	DBT	0.816974912	2.47E-20
UVM	Cell metabolism gene	PTCD3	CLOCK	0.817816666	2.10E-20
UVM	Cell metabolism gene	PTCD3	PNPLA8	0.819247002	1.59E-20
UVM	Cell metabolism gene	PTCD3	ARFGEF2	0.819296074	1.57E-20
UVM	Cell metabolism gene	PTCD3	HMGCS1	0.819546783	1.50E-20
UVM	Cell metabolism gene	PTCD3	COL4A3BP	0.821347206	1.05E-20
UVM	Cell metabolism gene	PTCD3	HIF1A	0.822267138	8.74E-21
UVM	Cell metabolism gene	PTCD3	PSME4	0.822453558	8.43E-21
UVM	Cell metabolism gene	PTCD3	SEH1L	0.82319554	7.26E-21
UVM	Cell metabolism gene	PTCD3	PSMD14	0.823876011	6.34E-21
UVM	Cell metabolism gene	PTCD3	MINPP1	0.825091341	4.96E-21
UVM	Cell metabolism gene	PTCD3	CNOT2	0.827698913	2.91E-21
UVM	Cell metabolism gene	PTCD3	CNOT8	0.82910867	2.17E-21
UVM	Cell metabolism gene	PTCD3	PHAX	0.829829123	1.87E-21
UVM	Cell metabolism gene	PTCD3	FAR1	0.830440609	1.64E-21
UVM	Cell metabolism gene	PTCD3	GPD2	0.830801886	1.52E-21
UVM	Cell metabolism gene	PTCD3	SPTLC1	0.832566119	1.05E-21
UVM	Cell metabolism gene	PTCD3	CCT2	0.833095204	9.37E-22
UVM	Cell metabolism gene	PTCD3	PIKFYVE	0.837004384	4.02E-22
UVM	Cell metabolism gene	PTCD3	NUPL2	0.837858388	3.34E-22
UVM	Cell metabolism gene	PTCD3	SACM1L	0.841296066	1.55E-22
UVM	Cell metabolism gene	PTCD3	MTMR6	0.842306596	1.23E-22
UVM	Cell metabolism gene	PTCD3	UGGT2	0.843810499	8.74E-23
UVM	Cell metabolism gene	PTCD3	PSMC6	0.847386114	3.80E-23
UVM	Cell metabolism gene	PTCD3	PIK3C3	0.849052351	2.56E-23
UVM	Cell metabolism gene	PTCD3	NUPL1	0.849701566	2.19E-23
UVM	Cell metabolism gene	PTCD3	DIS3	0.853540684	8.64E-24
UVM	Cell metabolism gene	PTCD3	PRKAA1	0.853998028	7.71E-24
UVM	Cell metabolism gene	PTCD3	RANBP2	0.855005483	6.01E-24
UVM	Cell metabolism gene	PTCD3	NUP107	0.856422599	4.21E-24
UVM	Cell metabolism gene	PTCD3	EDEM3	0.858593401	2.43E-24
UVM	Cell metabolism gene	PTCD3	TNPO1	0.862805851	8.12E-25
UVM	Cell metabolism gene	PTCD3	LCLAT1	0.863436289	6.87E-25
UVM	Cell metabolism gene	PTCD3	MED17	0.866472145	3.03E-25
UVM	Cell metabolism gene	PTCD3	AGPS	0.869087347	1.48E-25
UVM	Cell metabolism gene	PTCD3	NUP50	0.879885733	6.37E-27
UVM	Cell metabolism gene	PTCD3	XPO1	0.9135342	3.32E-32
UVM	CGC	PTCD3	DICER1	0.800741925	4.87E-19
UVM	CGC	PTCD3	PALB2	0.804422945	2.54E-19
UVM	CGC	PTCD3	KTN1	0.805934041	1.94E-19
UVM	CGC	PTCD3	TOP1	0.806428454	1.77E-19
UVM	CGC	PTCD3	ETNK1	0.808585104	1.19E-19
UVM	CGC	PTCD3	ERCC3	0.809067045	1.09E-19
UVM	CGC	PTCD3	ATF1	0.812612168	5.66E-20
UVM	CGC	PTCD3	BAZ1A	0.813638244	4.66E-20
UVM	CGC	PTCD3	HNRNPA2B1	0.814428291	4.02E-20
UVM	CGC	PTCD3	BIRC6	0.814874622	3.69E-20
UVM	CGC	PTCD3	STAG2	0.814881748	3.68E-20
UVM	CGC	PTCD3	RGPD3	0.815700262	3.15E-20
UVM	CGC	PTCD3	RABEP1	0.817003203	2.45E-20
UVM	CGC	PTCD3	EML4	0.817481279	2.24E-20
UVM	CGC	PTCD3	NF1	0.819050975	1.65E-20
UVM	CGC	PTCD3	CDC73	0.820124559	1.34E-20
UVM	CGC	PTCD3	SMARCE1	0.821247813	1.07E-20
UVM	CGC	PTCD3	FIP1L1	0.822001077	9.22E-21
UVM	CGC	PTCD3	HIF1A	0.822267138	8.74E-21
UVM	CGC	PTCD3	BCLAF1	0.827637657	2.95E-21
UVM	CGC	PTCD3	GOLGA5	0.829292198	2.09E-21
UVM	CGC	PTCD3	KDM5A	0.831064318	1.44E-21
UVM	CGC	PTCD3	SMAD4	0.831476945	1.32E-21
UVM	CGC	PTCD3	USP8	0.833381793	8.82E-22
UVM	CGC	PTCD3	MAP2K4	0.834976141	6.26E-22
UVM	CGC	PTCD3	BMPR1A	0.839509054	2.31E-22
UVM	CGC	PTCD3	NFE2L2	0.840171459	1.99E-22
UVM	CGC	PTCD3	ARID2	0.840994392	1.66E-22
UVM	CGC	PTCD3	RAD17	0.842400755	1.21E-22
UVM	CGC	PTCD3	CREB1	0.842648706	1.14E-22
UVM	CGC	PTCD3	MSH2	0.851201777	1.53E-23
UVM	CGC	PTCD3	ZMYM2	0.85126776	1.50E-23
UVM	CGC	PTCD3	RANBP2	0.855005483	6.01E-24
UVM	CGC	PTCD3	SUZ12	0.856901921	3.73E-24
UVM	CGC	PTCD3	HSP90AA1	0.857471928	3.23E-24
UVM	CGC	PTCD3	CUL3	0.860161403	1.62E-24
UVM	CGC	PTCD3	POT1	0.86641175	3.08E-25
UVM	CGC	PTCD3	DDX5	0.87813181	1.08E-26
UVM	CGC	PTCD3	SF3B1	0.882052435	3.27E-27
UVM	CGC	PTCD3	PMS1	0.886916318	6.95E-28
UVM	CGC	PTCD3	FBXO11	0.887480093	5.78E-28
UVM	CGC	PTCD3	ATM	0.900214707	6.85E-30
UVM	CGC	PTCD3	XPO1	0.9135342	3.32E-32
UVM	Epifactor	PTCD3	DDX50	0.802852065	3.36E-19
UVM	Epifactor	PTCD3	MASTL	0.803449477	3.02E-19
UVM	Epifactor	PTCD3	SMARCA5	0.805939138	1.93E-19
UVM	Epifactor	PTCD3	ZMYND11	0.808462676	1.22E-19
UVM	Epifactor	PTCD3	BRWD1	0.809801081	9.55E-20
UVM	Epifactor	PTCD3	NIPBL	0.810251707	8.79E-20
UVM	Epifactor	PTCD3	CDK17	0.810870436	7.83E-20
UVM	Epifactor	PTCD3	CUL1	0.813532885	4.76E-20
UVM	Epifactor	PTCD3	BAZ1A	0.813638244	4.66E-20
UVM	Epifactor	PTCD3	UCHL5	0.813937942	4.41E-20
UVM	Epifactor	PTCD3	USP15	0.814723817	3.80E-20
UVM	Epifactor	PTCD3	BRCC3	0.815101206	3.53E-20
UVM	Epifactor	PTCD3	H2AFV	0.8157667	3.11E-20
UVM	Epifactor	PTCD3	UHRF2	0.816782196	2.56E-20
UVM	Epifactor	PTCD3	ATAD2B	0.816901342	2.50E-20
UVM	Epifactor	PTCD3	CLOCK	0.817816666	2.10E-20
UVM	Epifactor	PTCD3	INO80D	0.818779943	1.74E-20
UVM	Epifactor	PTCD3	CDC73	0.820124559	1.34E-20
UVM	Epifactor	PTCD3	BAZ2B	0.820641551	1.21E-20
UVM	Epifactor	PTCD3	PCGF6	0.820808423	1.17E-20
UVM	Epifactor	PTCD3	YEATS4	0.820971851	1.13E-20
UVM	Epifactor	PTCD3	CUL5	0.821207461	1.08E-20
UVM	Epifactor	PTCD3	SMARCE1	0.821247813	1.07E-20
UVM	Epifactor	PTCD3	HMGB1	0.821532362	1.01E-20
UVM	Epifactor	PTCD3	EPC1	0.823423943	6.94E-21
UVM	Epifactor	PTCD3	JMJD1C	0.825524428	4.54E-21
UVM	Epifactor	PTCD3	TDG	0.828494257	2.47E-21
UVM	Epifactor	PTCD3	VRK1	0.830679248	1.56E-21
UVM	Epifactor	PTCD3	KDM5A	0.831064318	1.44E-21
UVM	Epifactor	PTCD3	ARID4A	0.831683312	1.27E-21
UVM	Epifactor	PTCD3	YY1	0.835045058	6.17E-22
UVM	Epifactor	PTCD3	ARID2	0.840994392	1.66E-22
UVM	Epifactor	PTCD3	FAM175B	0.843232572	9.98E-23
UVM	Epifactor	PTCD3	NSL1	0.844361911	7.70E-23
UVM	Epifactor	PTCD3	AEBP2	0.846085413	5.16E-23
UVM	Epifactor	PTCD3	ACTR6	0.849653981	2.22E-23
UVM	Epifactor	PTCD3	EPC2	0.851009514	1.60E-23
UVM	Epifactor	PTCD3	ZMYM2	0.85126776	1.50E-23
UVM	Epifactor	PTCD3	PRKAA1	0.853998028	7.71E-24
UVM	Epifactor	PTCD3	CHD9	0.854585051	6.67E-24
UVM	Epifactor	PTCD3	SMEK1	0.855125699	5.83E-24
UVM	Epifactor	PTCD3	CUL2	0.85628388	4.36E-24
UVM	Epifactor	PTCD3	SUZ12	0.856901921	3.73E-24
UVM	Epifactor	PTCD3	HAT1	0.858971504	2.20E-24
UVM	Epifactor	PTCD3	CUL3	0.860161403	1.62E-24
UVM	Epifactor	PTCD3	PARG	0.862534086	8.72E-25
UVM	Epifactor	PTCD3	TLK1	0.867194002	2.49E-25
UVM	Epifactor	PTCD3	TAF7	0.86734005	2.39E-25
UVM	Epifactor	PTCD3	ZRANB3	0.867478458	2.30E-25
UVM	Epifactor	PTCD3	ATF2	0.870183251	1.09E-25
UVM	Epifactor	PTCD3	SMEK2	0.874180858	3.48E-26
UVM	Epifactor	PTCD3	SF3B1	0.882052435	3.27E-27
UVM	Epifactor	PTCD3	ATM	0.900214707	6.85E-30
UVM	IUPHAR	PTCD3	STK17A	0.800323009	5.24E-19
UVM	IUPHAR	PTCD3	HMGCR	0.801758645	4.08E-19
UVM	IUPHAR	PTCD3	TAOK3	0.802534185	3.55E-19
UVM	IUPHAR	PTCD3	MASTL	0.803449477	3.02E-19
UVM	IUPHAR	PTCD3	TOP1	0.806428454	1.77E-19
UVM	IUPHAR	PTCD3	MAPK6	0.806850491	1.64E-19
UVM	IUPHAR	PTCD3	ZMYND11	0.808462676	1.22E-19
UVM	IUPHAR	PTCD3	SGPP1	0.808727588	1.16E-19
UVM	IUPHAR	PTCD3	PREPL	0.808826277	1.14E-19
UVM	IUPHAR	PTCD3	SCYL2	0.808854195	1.14E-19
UVM	IUPHAR	PTCD3	STK38L	0.809351566	1.04E-19
UVM	IUPHAR	PTCD3	BRWD1	0.809801081	9.55E-20
UVM	IUPHAR	PTCD3	MAPK8	0.810053447	9.12E-20
UVM	IUPHAR	PTCD3	CDK17	0.810870436	7.83E-20
UVM	IUPHAR	PTCD3	TBK1	0.811461158	7.02E-20
UVM	IUPHAR	PTCD3	PLA2G12A	0.811989437	6.36E-20
UVM	IUPHAR	PTCD3	SRPK2	0.812378487	5.91E-20
UVM	IUPHAR	PTCD3	ATP6V0A2	0.81271759	5.55E-20
UVM	IUPHAR	PTCD3	PPARA	0.812999795	5.26E-20
UVM	IUPHAR	PTCD3	BAZ1A	0.813638244	4.66E-20
UVM	IUPHAR	PTCD3	BIRC6	0.814874622	3.69E-20
UVM	IUPHAR	PTCD3	PPAT	0.815636299	3.19E-20
UVM	IUPHAR	PTCD3	ATAD2B	0.816901342	2.50E-20
UVM	IUPHAR	PTCD3	CSNK1A1	0.817506318	2.23E-20
UVM	IUPHAR	PTCD3	CLOCK	0.817816666	2.10E-20
UVM	IUPHAR	PTCD3	VRK2	0.818103756	1.98E-20
UVM	IUPHAR	PTCD3	CSNK1G3	0.819529959	1.50E-20
UVM	IUPHAR	PTCD3	HMGCS1	0.819546783	1.50E-20
UVM	IUPHAR	PTCD3	BAZ2B	0.820641551	1.21E-20
UVM	IUPHAR	PTCD3	XIAP	0.821007355	1.12E-20
UVM	IUPHAR	PTCD3	ULK2	0.82157121	1.00E-20
UVM	IUPHAR	PTCD3	PSMD14	0.823876011	6.34E-21
UVM	IUPHAR	PTCD3	USP14	0.824281983	5.84E-21
UVM	IUPHAR	PTCD3	JMJD1C	0.825524428	4.54E-21
UVM	IUPHAR	PTCD3	PLK4	0.827194227	3.23E-21
UVM	IUPHAR	PTCD3	MAP4K3	0.827214234	3.21E-21
UVM	IUPHAR	PTCD3	VRK1	0.830679248	1.56E-21
UVM	IUPHAR	PTCD3	KDM5A	0.831064318	1.44E-21
UVM	IUPHAR	PTCD3	SPTLC1	0.832566119	1.05E-21
UVM	IUPHAR	PTCD3	MAP2K4	0.834976141	6.26E-22
UVM	IUPHAR	PTCD3	PIKFYVE	0.837004384	4.02E-22
UVM	IUPHAR	PTCD3	BMPR1A	0.839509054	2.31E-22
UVM	IUPHAR	PTCD3	NFE2L2	0.840171459	1.99E-22
UVM	IUPHAR	PTCD3	MARK3	0.840672563	1.78E-22
UVM	IUPHAR	PTCD3	DYRK1A	0.843170881	1.01E-22
UVM	IUPHAR	PTCD3	TRPM7	0.846577357	4.60E-23
UVM	IUPHAR	PTCD3	PIK3C3	0.849052351	2.56E-23
UVM	IUPHAR	PTCD3	NR2C1	0.849976637	2.05E-23
UVM	IUPHAR	PTCD3	ADAM17	0.853108468	9.60E-24
UVM	IUPHAR	PTCD3	PRKAA1	0.853998028	7.71E-24
UVM	IUPHAR	PTCD3	PRMT3	0.856369592	4.27E-24
UVM	IUPHAR	PTCD3	HSP90AA1	0.857471928	3.23E-24
UVM	IUPHAR	PTCD3	NAPEPLD	0.858413512	2.54E-24
UVM	IUPHAR	PTCD3	HAT1	0.858971504	2.20E-24
UVM	IUPHAR	PTCD3	TNKS2	0.86580915	3.63E-25
UVM	IUPHAR	PTCD3	TLK1	0.867194002	2.49E-25
UVM	IUPHAR	PTCD3	FBXO11	0.887480093	5.78E-28
UVM	IUPHAR	PTCD3	ATM	0.900214707	6.85E-30
UVM	IUPHAR	PTCD3	XPO1	0.9135342	3.32E-32
UVM	Kinase	PTCD3	STK17A	0.800323009	5.24E-19
UVM	Kinase	PTCD3	TAOK3	0.802534185	3.55E-19
UVM	Kinase	PTCD3	MASTL	0.803449477	3.02E-19
UVM	Kinase	PTCD3	MAPK6	0.806850491	1.64E-19
UVM	Kinase	PTCD3	SCYL2	0.808854195	1.14E-19
UVM	Kinase	PTCD3	STK38L	0.809351566	1.04E-19
UVM	Kinase	PTCD3	MAPK8	0.810053447	9.12E-20
UVM	Kinase	PTCD3	CDK17	0.810870436	7.83E-20
UVM	Kinase	PTCD3	TBK1	0.811461158	7.02E-20
UVM	Kinase	PTCD3	SRPK2	0.812378487	5.91E-20
UVM	Kinase	PTCD3	BAZ1A	0.813638244	4.66E-20
UVM	Kinase	PTCD3	SCYL3	0.814631666	3.86E-20
UVM	Kinase	PTCD3	CSNK1A1	0.817506318	2.23E-20
UVM	Kinase	PTCD3	VRK2	0.818103756	1.98E-20
UVM	Kinase	PTCD3	PAN3	0.818141227	1.97E-20
UVM	Kinase	PTCD3	CSNK1G3	0.819529959	1.50E-20
UVM	Kinase	PTCD3	COL4A3BP	0.821347206	1.05E-20
UVM	Kinase	PTCD3	ULK2	0.82157121	1.00E-20
UVM	Kinase	PTCD3	PLK4	0.827194227	3.23E-21
UVM	Kinase	PTCD3	MAP4K3	0.827214234	3.21E-21
UVM	Kinase	PTCD3	VRK1	0.830679248	1.56E-21
UVM	Kinase	PTCD3	MAP2K4	0.834976141	6.26E-22
UVM	Kinase	PTCD3	BMPR1A	0.839509054	2.31E-22
UVM	Kinase	PTCD3	MARK3	0.840672563	1.78E-22
UVM	Kinase	PTCD3	DYRK1A	0.843170881	1.01E-22
UVM	Kinase	PTCD3	TRPM7	0.846577357	4.60E-23
UVM	Kinase	PTCD3	PRKAA1	0.853998028	7.71E-24
UVM	Kinase	PTCD3	TLK1	0.867194002	2.49E-25
UVM	Kinase	PTCD3	ATM	0.900214707	6.85E-30
UVM	TF	PTCD3	ZNF440	0.800377681	5.19E-19
UVM	TF	PTCD3	ZNF146	0.800562845	5.03E-19
UVM	TF	PTCD3	NFXL1	0.800854687	4.78E-19
UVM	TF	PTCD3	ZNF207	0.800897376	4.74E-19
UVM	TF	PTCD3	IKZF5	0.801951184	3.94E-19
UVM	TF	PTCD3	ZNF449	0.802365336	3.66E-19
UVM	TF	PTCD3	ZNF43	0.802991212	3.28E-19
UVM	TF	PTCD3	ZNF225	0.803769981	2.85E-19
UVM	TF	PTCD3	ZBED5	0.803929743	2.77E-19
UVM	TF	PTCD3	ELF1	0.806111027	1.87E-19
UVM	TF	PTCD3	CREBZF	0.806833195	1.64E-19
UVM	TF	PTCD3	THAP5	0.807056459	1.58E-19
UVM	TF	PTCD3	BACH1	0.807603407	1.43E-19
UVM	TF	PTCD3	TOPORS	0.808051431	1.32E-19
UVM	TF	PTCD3	ZNF268	0.80813835	1.30E-19
UVM	TF	PTCD3	ZNF555	0.808675137	1.18E-19
UVM	TF	PTCD3	ZNF791	0.80868198	1.17E-19
UVM	TF	PTCD3	ZNF780A	0.809528888	1.00E-19
UVM	TF	PTCD3	ZC3H8	0.809689531	9.75E-20
UVM	TF	PTCD3	ZNF14	0.810826819	7.90E-20
UVM	TF	PTCD3	ZNF487	0.811238589	7.32E-20
UVM	TF	PTCD3	MEF2A	0.812091068	6.24E-20
UVM	TF	PTCD3	ZNF320	0.812150239	6.17E-20
UVM	TF	PTCD3	ZNF700	0.812377084	5.91E-20
UVM	TF	PTCD3	ATF1	0.812612168	5.66E-20
UVM	TF	PTCD3	ZNF800	0.812905109	5.36E-20
UVM	TF	PTCD3	PPARA	0.812999795	5.26E-20
UVM	TF	PTCD3	ZNF23	0.81386866	4.46E-20
UVM	TF	PTCD3	ZNF527	0.81416202	4.22E-20
UVM	TF	PTCD3	ZNF701	0.814241868	4.16E-20
UVM	TF	PTCD3	ZNF430	0.815026719	3.58E-20
UVM	TF	PTCD3	ZNF180	0.816043864	2.95E-20
UVM	TF	PTCD3	ZNF45	0.816059331	2.94E-20
UVM	TF	PTCD3	ZNF484	0.817452274	2.25E-20
UVM	TF	PTCD3	CLOCK	0.817816666	2.10E-20
UVM	TF	PTCD3	THAP6	0.81805327	2.00E-20
UVM	TF	PTCD3	ZNF181	0.818864357	1.71E-20
UVM	TF	PTCD3	ZNF510	0.820226631	1.31E-20
UVM	TF	PTCD3	BAZ2B	0.820641551	1.21E-20
UVM	TF	PTCD3	PCGF6	0.820808423	1.17E-20
UVM	TF	PTCD3	ZNF585B	0.821925526	9.36E-21
UVM	TF	PTCD3	ZNF234	0.821985421	9.25E-21
UVM	TF	PTCD3	ZNF140	0.82210236	9.04E-21
UVM	TF	PTCD3	HIF1A	0.822267138	8.74E-21
UVM	TF	PTCD3	ZNF28	0.822479221	8.38E-21
UVM	TF	PTCD3	ZNF347	0.823028554	7.51E-21
UVM	TF	PTCD3	VEZF1	0.824066039	6.10E-21
UVM	TF	PTCD3	ZNF420	0.826312126	3.87E-21
UVM	TF	PTCD3	DMTF1	0.830926553	1.48E-21
UVM	TF	PTCD3	ZNF410	0.831029724	1.45E-21
UVM	TF	PTCD3	SMAD4	0.831476945	1.32E-21
UVM	TF	PTCD3	ZNF131	0.8317984	1.24E-21
UVM	TF	PTCD3	ZNF195	0.83275	1.01E-21
UVM	TF	PTCD3	ZNF143	0.833836491	8.00E-22
UVM	TF	PTCD3	SMAD5	0.834361828	7.14E-22
UVM	TF	PTCD3	ZNF383	0.834491703	6.95E-22
UVM	TF	PTCD3	YY1	0.835045058	6.17E-22
UVM	TF	PTCD3	ZNF26	0.838890351	2.65E-22
UVM	TF	PTCD3	ZNF136	0.839591888	2.27E-22
UVM	TF	PTCD3	PRDM10	0.839744182	2.19E-22
UVM	TF	PTCD3	NFE2L2	0.840171459	1.99E-22
UVM	TF	PTCD3	ZNF44	0.840530601	1.84E-22
UVM	TF	PTCD3	ARID2	0.840994392	1.66E-22
UVM	TF	PTCD3	CREB1	0.842648706	1.14E-22
UVM	TF	PTCD3	ZBTB1	0.844748383	7.04E-23
UVM	TF	PTCD3	AEBP2	0.846085413	5.16E-23
UVM	TF	PTCD3	GPBP1	0.847487607	3.71E-23
UVM	TF	PTCD3	ZBTB6	0.849206456	2.47E-23
UVM	TF	PTCD3	NR2C1	0.849976637	2.05E-23
UVM	TF	PTCD3	SP3	0.849977579	2.05E-23
UVM	TF	PTCD3	FOXN2	0.856346062	4.30E-24
UVM	TF	PTCD3	PRMT3	0.856369592	4.27E-24
UVM	TF	PTCD3	CEBPZ	0.860578173	1.46E-24
UVM	TF	PTCD3	ATF2	0.870183251	1.09E-25
UVM	TF	PTCD3	PURB	0.870361253	1.03E-25
UVM	TF	PTCD3	ZNF658	0.872834377	5.13E-26
UVM	TSG	PTCD3	DICER1	0.800741925	4.87E-19
UVM	TSG	PTCD3	RBL1	0.800901066	4.74E-19
UVM	TSG	PTCD3	EXTL2	0.800924031	4.72E-19
UVM	TSG	PTCD3	TANK	0.80268545	3.46E-19
UVM	TSG	PTCD3	PALB2	0.804422945	2.54E-19
UVM	TSG	PTCD3	TOPORS	0.808051431	1.32E-19
UVM	TSG	PTCD3	RBBP8	0.808410045	1.23E-19
UVM	TSG	PTCD3	ZMYND11	0.808462676	1.22E-19
UVM	TSG	PTCD3	GTPBP4	0.80874577	1.16E-19
UVM	TSG	PTCD3	PPARA	0.812999795	5.26E-20
UVM	TSG	PTCD3	CUL1	0.813532885	4.76E-20
UVM	TSG	PTCD3	PDS5B	0.813699434	4.61E-20
UVM	TSG	PTCD3	UHRF2	0.816782196	2.56E-20
UVM	TSG	PTCD3	CSNK1A1	0.817506318	2.23E-20
UVM	TSG	PTCD3	NF1	0.819050975	1.65E-20
UVM	TSG	PTCD3	CDC73	0.820124559	1.34E-20
UVM	TSG	PTCD3	CUL5	0.821207461	1.08E-20
UVM	TSG	PTCD3	HIF1A	0.822267138	8.74E-21
UVM	TSG	PTCD3	DMTF1	0.830926553	1.48E-21
UVM	TSG	PTCD3	KDM5A	0.831064318	1.44E-21
UVM	TSG	PTCD3	SMAD4	0.831476945	1.32E-21
UVM	TSG	PTCD3	FAM188A	0.83181747	1.23E-21
UVM	TSG	PTCD3	NEDD4	0.83228232	1.11E-21
UVM	TSG	PTCD3	GORAB	0.833560833	8.49E-22
UVM	TSG	PTCD3	MAP2K4	0.834976141	6.26E-22
UVM	TSG	PTCD3	BMPR1A	0.839509054	2.31E-22
UVM	TSG	PTCD3	IFT88	0.840219638	1.97E-22
UVM	TSG	PTCD3	ARID2	0.840994392	1.66E-22
UVM	TSG	PTCD3	PPM1A	0.845809642	5.50E-23
UVM	TSG	PTCD3	DCLRE1A	0.849535836	2.28E-23
UVM	TSG	PTCD3	WDR11	0.85115795	1.55E-23
UVM	TSG	PTCD3	MSH2	0.851201777	1.53E-23
UVM	TSG	PTCD3	PRKAA1	0.853998028	7.71E-24
UVM	TSG	PTCD3	CUL2	0.85628388	4.36E-24
UVM	TSG	PTCD3	SUZ12	0.856901921	3.73E-24
UVM	TSG	PTCD3	APAF1	0.857274616	3.40E-24
UVM	TSG	PTCD3	NAPEPLD	0.858413512	2.54E-24
UVM	TSG	PTCD3	GGNBP2	0.859125236	2.12E-24
UVM	TSG	PTCD3	INTS6	0.860573544	1.46E-24
UVM	TSG	PTCD3	SMCHD1	0.861909293	1.03E-24
UVM	TSG	PTCD3	KRIT1	0.880498119	5.28E-27
UVM	TSG	PTCD3	RINT1	0.883424305	2.13E-27
UVM	TSG	PTCD3	MLH3	0.892055652	1.25E-28
UVM	TSG	PTCD3	ATM	0.900214707	6.85E-30

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
BRCA	PTCD3	MRPS27	-2.1331392862776	0.000127527962379903
LIHC	PTCD3	MRPS31	-1.07565232256163	0.000180054839259286
KICH	PTCD3	MRPS5	1.25108287838437	0.000249803066253662
HNSC	PTCD3	MRPS23	-1.64850118241992	0.0007221434505027
THCA	PTCD3	MRPS23	1.86640051281615	0.000772056397653126
KIRC	PTCD3	MRPS18B	-1.08999348010674	0.00208385211535325
LUAD	PTCD3	MRPS31	1.58140915700442	0.00351308111790755
CHOL	PTCD3	MRPS23	-3.47507217165732	0.00390625
PRAD	PTCD3	MRPS9	1.04379115553269	0.00496210155254694
CHOL	PTCD3	MRPS18B	-1.34341961473083	0.0078125
KICH	PTCD3	MRPS2	1.26543989555015	0.0114533305168152
KICH	PTCD3	MRPS31	-1.44171613577495	0.0173123478889465
BLCA	PTCD3	MRPS18B	-2.79316203705083	0.0180816650390625
ESCA	PTCD3	MRPS5	-2.15440118747854	0.0185546875
LUAD	PTCD3	MRPS18B	-2.59132604284176	0.0228310323601027
ESCA	PTCD3	MRPS2	-3.20556788084675	0.0244140625
THCA	PTCD3	MRPS11	-3.10694728540962	0.0252226935182201
COAD	PTCD3	MRPS31	1.25930610083678	0.0253507494926453
STAD	PTCD3	MRPS18B	-2.18783845061495	0.0341199110262096
BLCA	PTCD3	MRPS11	-2.30276998968219	0.040130615234375
BLCA	PTCD3	MRPS31	-1.74989716581638	0.0445594787597656
KICH	PTCD3	MRPS22	1.59345779884986	0.0451226830482483
LIHC	PTCD3	MRPS23	-3.60547266789887	1.76596269781643e-07
LUAD	PTCD3	MRPS5	-2.20881945885927	1.77904381378076e-06
LUSC	PTCD3	MRPS9	-3.60637641031661	1.82498668910368e-07
LUSC	PTCD3	MRPS2	-2.70930846488508	1.92864354932136e-09
LUAD	PTCD3	MRPS9	-1.32894454884901	1.98978698949574e-05
LUAD	PTCD3	MRPS27	-2.46461120873599	2.13247131179291e-05
BRCA	PTCD3	MRPS11	-1.24304977976804	2.31302509538916e-07
LIHC	PTCD3	MRPS2	-1.14771055358828	4.2584580238307e-05
LUSC	PTCD3	MRPS5	-7.65956389962319	4.27210217182982e-06
LUSC	PTCD3	MRPS11	-2.9004097541444	5.43966600483641e-07
PRAD	PTCD3	MRPS31	1.42878008978338	6.76861513404814e-05
THCA	PTCD3	MRPS31	-1.55759809933211	6.91106419786075e-09
KIRC	PTCD3	MRPS31	-4.32541004240865	9.31897250092369e-08

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with PTCD3

ATF4, RFXANK, LUC7L2, HGS, H2AFX, ICT1, Ybx1, SIRT7, HNRNPA1, CUL3, CAND1, RNR1, MRPS15, SYNCRIP, FAM3C, PLP2, CD55, ACIN1, MPV17, ESR2, C1QBP, PARK2, GRSF1, STAU1, CEP250, TP53, FBXW11, SUZ12, RNF2, BMI1, NOL12, RPL13, NSA2, TRA2A, RPL6, NIFK, MRPS2, ZC3H3, RPS8, TRMT10B, ZBTB38, ZNF707, LUC7L, MRPS31, MRPS5, MRPS11, NTRK1, DAP3, MRPS18B, MRPS23, MRPS28, MRPS35, MRPS9, MRPS22, MED23, LCA5, SPICE1, SSX2IP, LNX2, BIRC7, Ar, Rab5c, Mta2, Ruvbl1, Pcgf1, Arhgef17, Klhl21, Ksr1, ERBB3, NANOG, POU5F1, ZNF746, TBC1D2B, MRPS34, MRPS27, AURKAIP1, E4F1, ZBTB48, PDGFB, ZFC3H1, SNRNP70, CCDC59, FGF8, RBM42, ZNF2, ZNF331, RRS1, RBM38, CFTR, ARMC8, EFTUD2, LARP7, UBE3A, HEXIM1, MEPCE, SNAI1, EZH2, RECQL4, MB21D1, MYC, AIFM1, FBL, HIST1H3A, RPS6, MRM1, SCO1, HSPD1, PDK1, COX14, COX4I1, TRMT61B, KIAA1429, RC3H1, NR2C2, TCF7L2, ALYREF, MAP3K14, Dppa3, PTPN3, HMGB1, BIRC3, PLEKHA4, PINK1, MIRLET7A2, MIRLET7F2, MIRLET7G, MIR18B, MIR21, MIR34B, MIR34C, MIR128-2, MIR200B, MIR200C, MIR205, MIR214, MIR363, PTPRR, PARL, ESR1, IMMP2L, CELF1, DAZL, ELAVL1, IGF2BP1, IGF2BP2, MEX3B, PRRC2A, RBMS1, XRN2, ZC3HAV1, NXF1, SMG7, SP100, SP110, ACAD9, AUH, C12orf65, C17orf80, C21orf33, C6orf203, C8orf82, MCUR1, CCDC90B, CHCHD1, CLPB, COX15, CRYZ, CS, DDX28, DHX30, DIABLO, EXD2, FASTKD2, FASTKD3, FASTKD5, GFM1, GFM2, HINT2, LONP1, LRPPRC, MCU, CCDC109B, MDH2, METTL15, METTL17, APOO, MRPL11, MRPS12, MRPS26, MRRF, MTERF3, MTFMT, MTG1, MTG2, MTIF2, MTIF3, MTRF1, MTRF1L, NGRN, OTC, PMPCA, PMPCB, RMND1, RPUSD3, RPUSD4, SLC25A51, SLIRP, SSBP1, SURF1, TACO1, TBRG4, TEFM, TFAM, C19orf52, TMEM70, TRUB2, TSFM, TUFM, VWA8, MKI67, MAFB, Apc2, RBM39, nsp13, DNAJC21, DNAJA3, DNAJC15, DNAJC19, DNAJC28, DNAJC30, DNAJC4, DNAJC9, HSCB, HSPA9, AMOTL1, UFL1, DDRGK1, AARS2, COX8A, PDHA1, TRAP1, FZR1, ZBTB2, MRPS6, SRSF3, ABT1, HNRNPU, MRPS17, ZNF17, H1FNT, MRPS18C, YBX2, PRR3, MRPS25, YBX1, SRSF5, SRSF1, ZNF460, ZNF689, RPS9, SRP14, RPL10, ERAL1, RPL19, RBMS2, HIST1H2AM, APOBEC3D, MCAT, RPL35, MRPL2, RPL4, LIN28A, SRSF7, ZNF346, SRSF6, NEIL1, RPL36AL, GLTSCR2, ZNF574, RPL17, MRPS24, BTF3, EP300, AGO2, AGO1, RCHY1, KLF12, SOX15, SOX2, TLX2, KLF15, KLF16, KLF4, ZEB1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
PTCD3	chr2	86346042	A	G	single_nucleotide_variant	Pathogenic	Combined_oxidative_phosphorylation_deficiency_51	SO:0001574\|splice_acceptor_variant	SO:0001574\|splice_acceptor_variant
PTCD3	chr2	86362075	C	CCT	Microsatellite	Pathogenic	Combined_oxidative_phosphorylation_deficiency_51	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
PTCD3	BRCA	chr2	86344259	86344259	G	A	Missense_Mutation	p.D131N	7
PTCD3	OV	chr2	86352130	86352130	C	T	Silent	p.N243N	3
PTCD3	LIHC	chr2	86344237	86344237	A	G	Silent		3
PTCD3	PAAD	chr2	86354302	86354302	G	A	Missense_Mutation	p.V324I	3
PTCD3	UCEC	chr2	86352950	86352950	G	T	Missense_Mutation	p.A300S	2
PTCD3	DLBC	chr2	86352925	86352925	A	G	Silent	p.V291V	2
PTCD3	LIHC	chr2	86344258	86344258	G	-	Frame_Shift_Del	p.K130fs	2
PTCD3	UCEC	chr2	86357814	86357814	G	T	Missense_Mutation	p.M397I	2
PTCD3	STAD	chr2	86352984	86352984	A	-	Frame_Shift_Del	p.E311fs	2
PTCD3	BLCA	chr2	86333455	86333455	G	A	Missense_Mutation	p.E29K	2
PTCD3	PRAD	chr2	86360495	86360495	G	A	Missense_Mutation	p.M493I	2
PTCD3	LIHC	chr2	86359483	86359483	G	-	Frame_Shift_Del	p.G437fs	2
PTCD3	HNSC	chr2	86352147	86352147	C	T	Missense_Mutation	p.S249F	2
PTCD3	UCEC	chr2	86357833	86357833	A	G	Missense_Mutation	p.R404G	2
PTCD3	LIHC	chr2	86359539	86359539	T	-	Frame_Shift_Del	p.N455fs	2
PTCD3	HNSC	chr2	86361419	86361419	T	G	Missense_Mutation	p.S516R	2
PTCD3	UCEC	chr2	86359497	86359497	C	T	Silent	p.T441	2
PTCD3	BLCA	chr2	86364195	86364195	C	T	Silent	p.F637F	2
PTCD3	ESCA	chr2	86352947	86352947	G	A	Missense_Mutation	p.E299K	2
PTCD3	HNSC	chr2	86350830	86350830	G	T	Nonsense_Mutation	p.E221*	2
PTCD3	UCEC	chr2	86360331	86360331	G	T	Missense_Mutation	p.M468I	2
PTCD3	TGCT	chr2	86361968	86361968	G	C	Missense_Mutation		2
PTCD3	UCEC	chr2	86360337	86360337	A	C	Missense_Mutation	p.Q470H	2
PTCD3	TGCT	chr2	86361968	86361968	G	C	Missense_Mutation	p.V546L	2
PTCD3	UCEC	chr2	86335503	86335503	G	T	Missense_Mutation	p.K45N	2
PTCD3	STAD	chr2	86352157	86352157	A	G	Silent	p.P252P	2
PTCD3	UCEC	chr2	86360381	86360381	T	C	Splice_Site	e18+2	2
PTCD3	KIRC	chr2	86359530	86359530	A	G	Silent	p.Q452Q	2
PTCD3	HNSC	chr2	86333420	86333420	G	C	Missense_Mutation		2
PTCD3	UCEC	chr2	86335628	86335628	G	T	Nonsense_Mutation	p.E55*	2
PTCD3	STAD	chr2	86352131	86352131	G	A	Missense_Mutation	p.A244T	2
PTCD3	UCEC	chr2	86360517	86360517	G	T	Missense_Mutation	p.D501Y	2
PTCD3	CESC	chr2	86338249	86338249	G	A	Missense_Mutation		2
PTCD3	UCEC	chr2	86335651	86335651	G	T	Missense_Mutation	p.K62N	2
PTCD3	STAD	chr2	86352118	86352118	A	G	Silent	p.R239R	2
PTCD3	UCEC	chr2	86364216	86364216	C	A	Silent	p.G644	2
PTCD3	KIRC	chr2	86361451	86361451	T	A	Missense_Mutation	p.L527Q	2
PTCD3	PAAD	chr2	86354302	86354302	G	A	Missense_Mutation		2
PTCD3	SKCM	chr2	86362103	86362103	G	A	Missense_Mutation	p.E591K	2
PTCD3	UCEC	chr2	86350884	86350884	C	T	Nonsense_Mutation	p.R239*	2
PTCD3	STAD	chr2	86364655	86364655	C	T	Silent	p.S681S	2
PTCD3	UCEC	chr2	86352160	86352160	G	T	Missense_Mutation	p.E253D	2
PTCD3	STAD	chr2	86355071	86355071	G	A	Silent	p.S368S	2
PTCD3	HNSC	chr2	86338237	86338237	G	T	Missense_Mutation		1
PTCD3	LUAD	chr2	86361965	86361965	C	T	Nonsense_Mutation	p.Q545*	1
PTCD3	SKCM	chr2	86344203	86344203	C	T	Missense_Mutation	p.S112F	1
PTCD3	STAD	chr2	86335644	86335645	-	A	Frame_Shift_Ins	p.P60fs	1
PTCD3	BLCA	chr2	86354347	86354347	C	G	Missense_Mutation	p.L339V	1
PTCD3	KIRP	chr2	86348656	86348656	A	G	Missense_Mutation	p.Y198C	1
PTCD3	PRAD	chr2	86354404	86354404	C	A	Missense_Mutation	p.R358S	1
PTCD3	THYM	chr2	86354360	86354360	G	T	Missense_Mutation	p.R343L	1
PTCD3	HNSC	chr2	86338237	86338237	G	T	Splice_Site	p.D66_splice	1
PTCD3	LUAD	chr2	86350836	86350836	G	A	Missense_Mutation	p.D223N	1
PTCD3	SKCM	chr2	86360313	86360313	C	T	Silent	p.F462F	1
PTCD3	LUAD	chr2	86346107	86346107	C	T	Nonsense_Mutation	p.R160*	1
PTCD3	KIRP	chr2	86352175	86352175	C	A	Silent		1
PTCD3	THYM	chr2	86344193	86344193	G	T	Missense_Mutation	p.A109S	1
PTCD3	DLBC	chr2	86358214	86358214	G	C	Missense_Mutation	p.Q417H	1
PTCD3	SKCM	chr2	86364119	86364119	A	G	Missense_Mutation	p.N612S	1
PTCD3	LUAD	chr2	86352636	86352636	A	C	Missense_Mutation	p.H288P	1
PTCD3	STAD	chr2	86352159	86352159	A	G	Missense_Mutation	p.E253G	1
PTCD3	BLCA	chr2	86346056	86346056	G	C	Missense_Mutation	p.E143Q	1
PTCD3	LGG	chr2	86348616	86348616	C	G	Missense_Mutation	p.L185V	1
PTCD3	ESCA	chr2	86361473	86361473	C	T	Silent	p.L534	1
PTCD3	READ	chr2	86333384	86333384	C	G	Missense_Mutation	p.S5C	1
PTCD3	UCEC	chr2	86355092	86355092	T	C	Silent	p.I375I	1
PTCD3	SKCM	chr2	86352579	86352579	A	G	Splice_Site	p.H269_splice	1
PTCD3	LUSC	chr2	86361473	86361473	C	A	Silent	p.L534L	1
PTCD3	STAD	chr2	86335645	86335646	-	A	Frame_Shift_Ins	p.P60fs	1
PTCD3	LGG	chr2	86364603	86364603	G	T	Missense_Mutation	p.S664I	1
PTCD3	LIHC	chr2	86344249	86344249	T	-	Frame_Shift_Del	p.Y127fs	1
PTCD3	READ	chr2	86352196	86352196	A	C	Silent	p.G265G	1
PTCD3	UCEC	chr2	86364216	86364216	C	A	Silent	p.G644G	1
PTCD3	BLCA	chr2	86354347	86354347	C	G	Missense_Mutation		1
PTCD3	SKCM	chr2	86344204	86344204	C	T	Silent	p.S112S	1
PTCD3	LUSC	chr2	86346095	86346095	G	A	Missense_Mutation	p.A156T	1
PTCD3	BLCA	chr2	86344253	86344253	C	G	Missense_Mutation	p.Q129E	1
PTCD3	LGG	chr2	86355071	86355074	GCTT	-	Frame_Shift_Del	p.SL368fs	1
PTCD3	ESCA	chr2	86361473	86361473	C	T	Silent		1
PTCD3	LIHC	chr2	86354408	86354408	A	-	Frame_Shift_Del	p.E359fs	1
PTCD3	READ	chr2	86362002	86362002	C	A	Missense_Mutation	p.S557Y	1
PTCD3	UCEC	chr2	86359497	86359497	C	T	Silent	p.T441T	1
PTCD3	BLCA	chr2	86333455	86333455	G	A	Missense_Mutation		1
PTCD3	KIRC	chr2	86353001	86353001	C	A	Missense_Mutation	p.L317M	1
PTCD3	SKCM	chr2	86355108	86355108	C	T	Nonsense_Mutation	p.Q381*	1
PTCD3	LUSC	chr2	86352933	86352933	T	G	Missense_Mutation	p.F294C	1
PTCD3	BLCA	chr2	86355070	86355070	C	T	Missense_Mutation	p.S368L	1
PTCD3	LGG	chr2	86364603	86364603	G	T	Missense_Mutation		1
PTCD3	GBM	chr2	86352973	86352973	G	T	Missense_Mutation		1
PTCD3	LIHC	chr2	86362079	86362079	T	-	Frame_Shift_Del	p.F583fs	1
PTCD3	SARC	chr2	86359515	86359515	C	A	Missense_Mutation		1
PTCD3	BLCA	chr2	86344205	86344205	G	T	Missense_Mutation		1
PTCD3	LUSC	chr2	86359468	86359468	G	A	Missense_Mutation	p.A432T	1
PTCD3	THCA	chr2	86364653	86364653	A	G	Missense_Mutation		1
PTCD3	LGG	chr2	86348616	86348616	C	G	Missense_Mutation		1
PTCD3	LIHC	chr2	86358206	86358206	T	-	Frame_Shift_Del	p.F416fs	1
PTCD3	SARC	chr2	86362092	86362092	G	T	Missense_Mutation		1
PTCD3	BLCA	chr2	86346056	86346056	G	C	Missense_Mutation		1
PTCD3	KIRC	chr2	86364158	86364158	C	G	Missense_Mutation	p.S625C	1
PTCD3	THYM	chr2	86360469	86360469	G	T	Missense_Mutation		1
PTCD3	HNSC	chr2	86352147	86352147	C	T	Missense_Mutation		1
PTCD3	LIHC	chr2	86360478	86360478	C	-	Frame_Shift_Del	p.P488fs	1
PTCD3	SARC	chr2	86364596	86364596	G	T	Missense_Mutation		1
PTCD3	BLCA	chr2	86364195	86364195	C	T	Silent		1
PTCD3	THYM	chr2	86360469	86360469	G	T	Missense_Mutation	p.A485S	1
PTCD3	CESC	chr2	86364249	86364249	C	C	Silent		1
PTCD3	LIHC	chr2	86348628	86348628	A	G	Missense_Mutation	p.N189D	1
PTCD3	HNSC	chr2	86361419	86361419	T	G	Missense_Mutation		1
PTCD3	LUAD	chr2	86333332	86333332	A	T	Translation_Start_Site		1
PTCD3	BLCA	chr2	86344253	86344253	C	G	Missense_Mutation		1
PTCD3	KIRC	chr2	86350863	86350863	C	T	Missense_Mutation	p.H232Y	1
PTCD3	PAAD	chr2	86348679	86348679	G	T	Missense_Mutation		1
PTCD3	THYM	chr2	86354305	86354305	G	A	Missense_Mutation	p.A325T	1
PTCD3	COAD	chr2	86354360	86354360	G	A	Missense_Mutation	p.R343Q	1
PTCD3	LIHC	chr2	86362000	86362000	A	C	Missense_Mutation	p.K556N	1
PTCD3	HNSC	chr2	86344259	86344259	G	A	Missense_Mutation		1
PTCD3	LUAD	chr2	86359531	86359531	C	T	Missense_Mutation	p.H453Y	1
PTCD3	SKCM	chr2	86355108	86355108	C	T	Nonsense_Mutation	p.Q381X	1
PTCD3	BLCA	chr2	86355070	86355070	C	T	Missense_Mutation		1
PTCD3	KIRP	chr2	86352186	86352186	T	C	Missense_Mutation	p.M262T	1
PTCD3	THYM	chr2	86361418	86361418	G	T	Missense_Mutation	p.S516I	1
PTCD3	COAD	chr2	86354409	86354409	A	C	Missense_Mutation	p.E359D	1
PTCD3	LIHC	chr2	86333399	86333400	-	G	Frame_Shift_Ins	p.R10fs	1

Copy number variation (CNV) of PTCD3
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across PTCD3
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
73253	N/A	BM144871	PLCL1	chr2	199161000	-	PTCD3	chr2	86365258	-
94533	ESCA	TCGA-VR-A8ER	PTCD3	chr2	86362110	+	MPRIP	chr17	17075031	+
89639	OV	TCGA-25-2042	PTCD3	chr2	86335659	+	TPI1	chr12	6978851	+
73253	OV	TCGA-29-1761	RBM10	chrX	47006897	+	PTCD3	chr2	86363643	+
73290	STAD	TCGA-VQ-A8PH	RCC1	chr1	28834672	+	PTCD3	chr2	86363643	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUAD	PTCD3	0.013914330688573	0.38
HNSC	PTCD3	0.0217524702581867	0.57
SARC	PTCD3	0.0272748681923019	0.68
KICH	PTCD3	0.0374216198506173	0.9
TGCT	PTCD3	8.10319292444993e-05	0.0023

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
BRCA	PTCD3	0.00035658734650894	0.012
PAAD	PTCD3	0.000998431088356693	0.032
SARC	PTCD3	0.0337036281612799	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0023264	Leigh Disease	3	CLINGEN
C1838951	LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY	3	CLINGEN
C1850597	Leigh Syndrome Due To Mitochondrial Complex II Deficiency	3	CLINGEN
C1850598	Leigh Syndrome due to Mitochondrial Complex III Deficiency	3	CLINGEN
C1850599	Leigh Syndrome due to Mitochondrial Complex IV Deficiency	3	CLINGEN
C1850600	Leigh Syndrome due to Mitochondrial Complex V Deficiency	3	CLINGEN
C2931891	Necrotizing encephalopathy, infantile subacute, of Leigh	3	CLINGEN