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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: NAT10 (NCBI Gene ID:55226)

Gene Summary

Gene Summary

Gene Information	Gene Name: NAT10
	Gene ID: 55226
	Gene Symbol	NAT10
	Gene ID	55226
	Gene Name	N-acetyltransferase 10
	Synonyms	ALP\|Kre33\|NET43
	Cytomap	11p13
	Type of Gene	protein-coding
	Description	RNA cytidine acetyltransferase18S rRNA cytosine acetyltransferaseN-acetyltransferase 10 (GCN5-related)N-acetyltransferase-like protein
	Modification date	20200313
	UniProtAcc	Q9H0A0

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0045727	Positive regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NAT10	GO:0045727	positive regulation of translation	30449621

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
NAT10	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'NAT10[title] AND translation [title] AND human.'

Gene	Title	PMID
NAT10	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000257829	34139726	34139841	Frame-shift
ENST00000257829	34160737	34160834	Frame-shift
ENST00000257829	34160931	34161042	In-frame
ENST00000257829	34162635	34162755	In-frame
ENST00000257829	34163265	34163364	In-frame
ENST00000257829	34164991	34165075	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000257829	34160931	34161042	4019	2515	2625	1025	769	806
ENST00000257829	34162635	34162755	4019	2799	2918	1025	864	904
ENST00000257829	34163265	34163364	4019	2919	3017	1025	904	937
ENST00000257829	34164991	34165075	4019	3092	3175	1025	962	989

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q9H0A0	904	937	1	1025	Chain	ID=PRO_0000215883;Note=RNA cytidine acetyltransferase
Q9H0A0	864	904	1	1025	Chain	ID=PRO_0000215883;Note=RNA cytidine acetyltransferase
Q9H0A0	769	806	1	1025	Chain	ID=PRO_0000215883;Note=RNA cytidine acetyltransferase
Q9H0A0	962	989	1	1025	Chain	ID=PRO_0000215883;Note=RNA cytidine acetyltransferase
Q9H0A0	904	937	702	1025	Region	Note=Required for localization to the nucleolus and midbody;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19303003;Dbxref=PMID:19303003
Q9H0A0	864	904	702	1025	Region	Note=Required for localization to the nucleolus and midbody;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19303003;Dbxref=PMID:19303003
Q9H0A0	769	806	702	1025	Region	Note=Required for localization to the nucleolus and midbody;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19303003;Dbxref=PMID:19303003
Q9H0A0	962	989	702	1025	Region	Note=Required for localization to the nucleolus and midbody;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19303003;Dbxref=PMID:19303003
Q9H0A0	904	937	934	934	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
Q9H0A0	962	989	984	984	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
Q9H0A0	962	989	987	987	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
Q9H0A0	962	989	983	983	Natural variant	ID=VAR_061894;Note=A->T;Dbxref=dbSNP:rs36006049
Q9H0A0	864	904	879	879	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9H0A0	962	989	971	971	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
CHOL	NAT10	-3.09817490794742	0.00390625
PRAD	NAT10	-1.17080723286244	0.00496210155254694
KICH	NAT10	-2.20206362077818	1.50799751281738e-05
STAD	NAT10	-6.13288998123572	1.72760337591171e-07
KIRC	NAT10	-1.40624570011691	1.96258882516009e-11
KIRP	NAT10	-1.08394446564703	2.3283064365387e-09
LUAD	NAT10	-3.07413769990618	3.40660700589176e-10

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
OV	NAT10	hsa-miR-28-5p	63	0.352428925125928	0.0107546364056926
UCEC	NAT10	hsa-miR-28-5p	63	-0.441100076394194	0.00959161249815749

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with NAT10 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
COAD	Cell metabolism gene	NAT10	POLR1B	0.803143339	1.56E-75
COAD	Epifactor	NAT10	KAT2A	0.806780574	1.02E-76
COAD	IUPHAR	NAT10	KAT2A	0.806780574	1.02E-76

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
LUSC	NAT10	RRP9	-1.88324097401974	0.00013362071971533
LIHC	NAT10	UTP18	-1.4814087628578	0.000201991820198738
KICH	NAT10	UTP18	1.66577244850777	0.000329077243804932
HNSC	NAT10	NOL10	1.91962588874833	0.000507211686226584
KIRP	NAT10	UTP18	-1.3047145064012	0.000837184488773346
LUAD	NAT10	RRP9	-1.26449027444859	0.00127825845990135
LIHC	NAT10	NOP58	-4.33698536477434	0.00149357664052089
ESCA	NAT10	UTP18	-1.76236197121972	0.001953125
ESCA	NAT10	BYSL	-1.41965432328034	0.0029296875
CHOL	NAT10	RRP9	-2.07501702621332	0.00390625
CHOL	NAT10	UTP18	-2.58175366678633	0.00390625
PRAD	NAT10	UTP6	-1.37804584930361	0.00468840651979362
ESCA	NAT10	RRP9	-1.05260329067721	0.013671875
ESCA	NAT10	AATF	-1.65936915563148	0.0185546875
UCEC	NAT10	BMS1	2.17268526631941	0.03125
ESCA	NAT10	UTP20	2.15266586209462	0.0419921875
STAD	NAT10	UTP6	-1.77410792178194	1.10594555735588e-06
KIRP	NAT10	BMS1	-1.91247228425091	1.11940316855908e-05
KIRP	NAT10	AATF	-2.84128856621319	1.26352533698082e-05
KIRP	NAT10	UTP6	-1.81335116166315	1.2875534594059e-06
KIRC	NAT10	AATF	-3.46641652591163	2.11933773649914e-11
STAD	NAT10	BYSL	-2.46996682866835	2.3283064365387e-09
BRCA	NAT10	AATF	-1.5406628370887	2.62695618358088e-10
KIRP	NAT10	NOL6	-1.66566465065518	3.51201742887497e-06
PRAD	NAT10	NOL10	-3.43204508705941	3.77428293642232e-05
BRCA	NAT10	NOL6	-2.54243794564841	3.94048164550614e-07
STAD	NAT10	RRP9	-3.90391972876191	4.09781932830811e-08
PRAD	NAT10	BYSL	-4.18834172449879	4.1396395841136e-09
LIHC	NAT10	AATF	-5.4117077682636	4.22970612218234e-07
LIHC	NAT10	UTP6	-2.5326249940914	4.2584580238307e-05
HNSC	NAT10	BYSL	1.83007134227969	5.27545735167224e-05
PRAD	NAT10	NOP58	-1.45377741371632	5.36984323097516e-05
STAD	NAT10	UTP18	-1.22554779819783	5.8719888329506e-07
KIRP	NAT10	RRP9	-1.71705215307207	5.97489997744561e-06
KIRC	NAT10	UTP6	-1.4406206070164	6.13427141633893e-11
LUAD	NAT10	AATF	-5.44978865232575	7.09793428673073e-08
THCA	NAT10	UTP6	1.37291396121381	7.52915292268072e-05
BRCA	NAT10	BYSL	-3.72440272841362	7.85448425978448e-18
KICH	NAT10	UTP6	1.58159398732587	8.34465026855468e-07

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with NAT10

LYAR, OTUB1, tat, TERT, TOP1, SIRT1, SIRT7, CUL3, CUL1, CAND1, GRK5, UTP20, DGCR8, DHX37, ESR1, FN1, ITGA4, BRCA1, CUL7, OBSL1, UBE2I, SUZ12, EED, RNF2, BMI1, ABCE1, FBXW11, NOL12, RPS2, RPS8, THUMPD1, NTRK1, ABCF2, EIF4G1, DDX18, IMP4, NOP58, RPS5, SRPK1, SSB, NOP2, RPL5, TSR1, IFI16, gag, HNRNPU, NPM1, RPL10, VIM, TFG, SYNCRIP, NOP56, IBTK, Eif3a, Eif3e, Srp72, 2310003H01Rik, Rrbp1, Ncaph, MCM5, CDC5L, TP53, MDM2, UBE2D2, UBC, C1orf131, CDC14B, NOL10, HIST1H1T, RPS14, ZNF512, MECP2, RPL18A, ZNF169, GPATCH4, FGF8, RRP8, RPS11, LASP1, TRIM25, MTF1, HNRNPL, LEO1, NAT10, ZNF574, PCBP1, CHD3, CHD4, LARP7, CDC34, RIOK1, HERC2, DCPS, TNRC6A, RBBP5, MYC, AURKB, CANX, CDK7, FBL, HIST1H3A, RAB11A, RPS6, TGOLN2, AURKAIP1, GRWD1, KIAA1429, DCAF13, RC3H1, NR2C2, PPARG, RPS6KA2, XRCC6, PRDM16, MECOM, HIST1H4A, SCARB2, HMGB1, BIRC3, STAU1, NFX1, WWP2, BRD7, SOX2, PLEKHA4, MORC2, PARP1, FANCD2, CCDC84, ZC3H18, MAP2K1, MYLK2, NCL, M, nsp13, nsp14, nsp4, nsp6, ORF14, ORF3a, ORF7a, ORF7b, SMC3, PDS5A, UBR5, CIT, ANLN, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, BRD2, MNDA, CHCHD1, SUMO2, MAFB, NUPR1, BRD4, Apc2, vpr, DNAJC9, MKRN1, DDX58, DDRGK1, ISG15, APEX1, CD3EAP, DDX23, DHX40, HIST1H2BG, NIFK, POLR1E, RPL31, RPS24, CIRH1A, ZNF330, FZR1, WDR5, NAA40, ZBTB2, RPS3, PNMAL1, MAGEB2, CCDC140, HIST2H2AC, HIST1H1C, SRSF4, KAL1, GLI4, NPM3, RPL4, NEURL4, RBM28, CBX6, RPL17, RPL13A, NMNAT1, ABT1, C12orf43, RPL13, CCDC137, LIN28B, AATF, APOBEC3C, RPS10, FGF13, RPL26L1, RPL19, ZNF467, H1FNT, RPL23A, HIST1H2AM, SELM, SRSF6, NGDN, H2AFB2, RPL23AP32, RBM19, RPSA, SURF6, RBM4B, RPSAP58, SRSF1, LIN28A, SENP3, FGFBP1, NEIL1, RPS19, RPL3, USE1, RPL35, YES1, RPS3A, RPLP0, KRR1, HIST1H1E, ZNF668, HIST1H1A, EP300, FBXW7, SREK1, CD2BP2, nsp1, DPP4, HECTD1, N, SIRT6, KLF16, BRD3,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
NAT10	chr11	34130357	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
NAT10	chr11	34133671	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
NAT10	chr11	34133767	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
NAT10	chr11	34135256	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
NAT10	chr11	34135349	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
NAT10	chr11	34139778	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
NAT10	chr11	34139840	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
NAT10	chr11	34152464	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
NAT10	chr11	34154641	C	T	single_nucleotide_variant	Benign	not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
NAT10	chr11	34161951	G	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
NAT10	chr11	34163339	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
NAT10	chr11	34163901	G	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
NAT10	chr11	34165053	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
NAT10	LUAD	chr11	34139979	34139979	G	T	Nonsense_Mutation	p.E237*	7
NAT10	UCEC	chr11	34160759	34160759	T	G	Missense_Mutation	p.S745A	3
NAT10	UCEC	chr11	34139806	34139806	G	A	Missense_Mutation	p.V213I	3
NAT10	UCEC	chr11	34129797	34129797	C	T	Nonsense_Mutation	p.R9*	3
NAT10	LIHC	chr11	34158307	34158307	C	-	Frame_Shift_Del	p.T716fs	3
NAT10	BRCA	chr11	34160944	34160944	G	T	Missense_Mutation	p.R774L	3
NAT10	BRCA	chr11	34164994	34164994	A	G	Missense_Mutation	p.Y963C	3
NAT10	BLCA	chr11	34156767	34156767	G	A	Missense_Mutation		3
NAT10	PAAD	chr11	34162000	34162000	C	A	Missense_Mutation	p.L825M	3
NAT10	LUAD	chr11	34160792	34160792	G	T	Missense_Mutation	p.D756Y	3
NAT10	KIRC	chr11	34161956	34161956	G	A	Missense_Mutation	p.R810Q	2
NAT10	UCEC	chr11	34139774	34139774	A	G	Missense_Mutation	p.D202G	2
NAT10	LIHC	chr11	34130369	34130369	G	-	Frame_Shift_Del	p.L63fs	2
NAT10	LGG	chr11	34152949	34152949	C	T	Missense_Mutation	p.S464F	2
NAT10	CESC	chr11	34162010	34162010	A	G	Missense_Mutation		2
NAT10	UCEC	chr11	34165048	34165048	C	T	Missense_Mutation	p.P981L	2
NAT10	LIHC	chr11	34152419	34152419	G	A	Missense_Mutation		2
NAT10	STAD	chr11	34130297	34130297	A	G	Missense_Mutation	p.I39M	2
NAT10	UCEC	chr11	34144047	34144047	G	T	Missense_Mutation	p.K274N	2
NAT10	SARC	chr11	34130376	34130376	A	G	Missense_Mutation	p.S66G	2
NAT10	CESC	chr11	34155888	34155888	C	T	Missense_Mutation		2
NAT10	UCEC	chr11	34167693	34167693	G	T	Missense_Mutation	p.R1011I	2
NAT10	STAD	chr11	34133754	34133754	G	C	Missense_Mutation	p.G119A	2
NAT10	SARC	chr11	34156835	34156835	C	T	Silent		2
NAT10	UCEC	chr11	34144133	34144133	C	T	Missense_Mutation	p.A303V	2
NAT10	LUAD	chr11	34167643	34167643	G	A	Silent	p.R994R	2
NAT10	UCEC	chr11	34167729	34167729	G	A	Missense_Mutation	p.R1023Q	2
NAT10	ESCA	chr11	34158541	34158541	G	T	Nonsense_Mutation	p.G727*	2
NAT10	LIHC	chr11	34152419	34152419	G	A	Missense_Mutation	p.S435N	2
NAT10	STAD	chr11	34129782	34129782	A	-	Frame_Shift_Del	p.R3fs	2
NAT10	UCEC	chr11	34145924	34145924	C	T	Nonsense_Mutation	p.R362*	2
NAT10	LUAD	chr11	34129826	34129826	A	G	Silent	p.V18V	2
NAT10	ESCA	chr11	34144020	34144020	G	T	Missense_Mutation	p.L265F	2
NAT10	STAD	chr11	34165024	34165024	A	G	Missense_Mutation	p.N973S	2
NAT10	UCEC	chr11	34154639	34154639	C	T	Missense_Mutation	p.P562S	2
NAT10	BLCA	chr11	34156767	34156767	G	A	Missense_Mutation	p.E653K	2
NAT10	SKCM	chr11	34129802	34129802	C	T	Silent	p.I10I	2
NAT10	UCEC	chr11	34154665	34154665	T	C	Silent	p.L570	2
NAT10	LGG	chr11	34139764	34139764	G	A	Missense_Mutation		2
NAT10	SKCM	chr11	34155890	34155890	C	T	Missense_Mutation	p.R587C	2
NAT10	BRCA	chr11	34160963	34160963	C	T	Silent	p.S780	2
NAT10	UCEC	chr11	34158212	34158212	C	T	Silent	p.V684	2
NAT10	UCEC	chr11	34129833	34129833	C	T	Missense_Mutation	p.R21W	2
NAT10	LIHC	chr11	34137375	34137375	G	A	Silent	p.V167V	2
NAT10	UCEC	chr11	34158214	34158214	T	C	Missense_Mutation	p.I685T	2
NAT10	LIHC	chr11	34137375	34137375	G	A	Silent		2
NAT10	BLCA	chr11	34167693	34167693	G	C	Missense_Mutation	p.R1011T	2
NAT10	UCEC	chr11	34129866	34129866	C	T	Nonsense_Mutation	p.R32*	2
NAT10	PAAD	chr11	34162000	34162000	C	A	Missense_Mutation		2
NAT10	LUAD	chr11	34153690	34153690	T	C	Silent	p.D513D	2
NAT10	UCEC	chr11	34158270	34158270	G	A	Missense_Mutation	p.E704K	2
NAT10	STAD	chr11	34144031	34144031	A	T	Missense_Mutation	p.E269V	2
NAT10	BLCA	chr11	34139781	34139781	C	G	Silent	p.L204L	2
NAT10	UCEC	chr11	34133706	34133706	G	A	Missense_Mutation	p.R103H	2
NAT10	CESC	chr11	34130342	34130342	A	G	Silent		2
NAT10	UCEC	chr11	34160750	34160750	G	A	Missense_Mutation	p.G742R	2
NAT10	LUAD	chr11	34139952	34139952	C	G	Missense_Mutation	p.L228V	2
NAT10	STAD	chr11	34160817	34160817	T	C	Missense_Mutation	p.L764P	2
NAT10	UCEC	chr11	34135344	34135344	C	T	Missense_Mutation	p.R152W	2
NAT10	LIHC	chr11	34144088	34144088	G	-	Frame_Shift_Del	p.R288fs	2
NAT10	CESC	chr11	34158223	34158223	G	A	Missense_Mutation		2
NAT10	UCEC	chr11	34163291	34163291	C	A	Missense_Mutation	p.A913D	2
NAT10	LUAD	chr11	34139802	34139802	C	T	Silent	p.S211S	2
NAT10	STAD	chr11	34163346	34163346	G	A	Silent	p.K931K	2
NAT10	READ	chr11	34140023	34140023	G	T	Missense_Mutation	p.L179F	1
NAT10	SKCM	chr11	34149087	34149087	C	T	Silent	p.L395L	1
NAT10	BLCA	chr11	34160786	34160786	G	A	Missense_Mutation	p.D754N	1
NAT10	PAAD	chr11	34162110	34162110	G	A	Silent	p.A861A	1
NAT10	SARC	chr11	34156835	34156835	C	T	Silent	p.S675S	1
NAT10	SKCM	chr11	34144084	34144084	G	A	Missense_Mutation	p.G287R	1
NAT10	BLCA	chr11	34129798	34129798	G	T	Missense_Mutation		1
NAT10	THYM	chr11	34158559	34158559	C	A	Missense_Mutation	p.L733M	1
NAT10	LUAD	chr11	34149090	34149090	C	G	Silent	p.P396P	1
NAT10	SKCM	chr11	34161016	34161016	G	A	Missense_Mutation	p.R726K	1
NAT10	BLCA	chr11	34167729	34167729	G	T	Missense_Mutation	p.R1023L	1
NAT10	DLBC	chr11	34133767	34133767	G	A	Silent	p.L123L	1
NAT10	READ	chr11	34152464	34152464	C	T	Missense_Mutation	p.T378M	1
NAT10	SKCM	chr11	34162704	34162704	C	T	Silent	p.P887P	1
NAT10	BLCA	chr11	34145864	34145864	G	T	Nonsense_Mutation	p.E342*	1
NAT10	KIRC	chr11	34163264	34163268	AGCTA	-	Splice_Site	p.904_splice	1
NAT10	LIHC	chr11	34156096	34156096	G	-	Frame_Shift_Del	p.R625fs	1
NAT10	PRAD	chr11	34144132	34144132	G	A	Missense_Mutation	p.A303T	1
NAT10	LGG	chr11	34135329	34135329	G	A	Missense_Mutation	p.V147M	1
NAT10	LUAD	chr11	34156118	34156118	C	A	Missense_Mutation	p.H632Q	1
NAT10	SKCM	chr11	34145400	34145400	C	T	Nonsense_Mutation	p.Q336*	1
NAT10	BLCA	chr11	34153758	34153758	C	G	Missense_Mutation		1
NAT10	THYM	chr11	34129835	34129835	G	A	Silent	p.R21R	1
NAT10	LIHC	chr11	34135326	34135326	C	-	Frame_Shift_Del	p.G145fs	1
NAT10	LUAD	chr11	34162078	34162078	C	G	Missense_Mutation	p.L851V	1
NAT10	SKCM	chr11	34152965	34152965	C	T	Silent	p.I397I	1
NAT10	BLCA	chr11	34130334	34130334	C	T	Missense_Mutation	p.R52W	1
NAT10	ESCA	chr11	34129782	34129782	A	-	Frame_Shift_Del	p.K5fs	1
NAT10	SKCM	chr11	34135386	34135386	G	A	Splice_Site		1
NAT10	BLCA	chr11	34145364	34145364	G	A	Missense_Mutation	p.E324K	1
NAT10	LIHC	chr11	34129848	34129848	T	-	Frame_Shift_Del	p.F26fs	1
NAT10	PRAD	chr11	34162694	34162694	T	C	Missense_Mutation	p.I884T	1
NAT10	LGG	chr11	34152413	34152413	A	C	Missense_Mutation	p.Q433P	1
NAT10	SARC	chr11	34156835	34156835	C	T	Silent	p.S675	1
NAT10	SKCM	chr11	34162732	34162732	C	T	Missense_Mutation	p.R897W	1
NAT10	BLCA	chr11	34139990	34139990	G	A	Silent		1
NAT10	CESC	chr11	34156077	34156077	G	T	Missense_Mutation		1
NAT10	BLCA	chr11	34129870	34129870	G	T	Missense_Mutation	p.G33V	1
NAT10	LUAD	chr11	34133651	34133651	C	T	Silent	p.L85L	1
NAT10	SKCM	chr11	34129780	34129780	G	T	Missense_Mutation	p.R3L	1
NAT10	LIHC	chr11	34139728	34139728	T	-	Splice_Site	p.F187_splice	1
NAT10	READ	chr11	34133608	34133608	G	T	Missense_Mutation	p.K70N	1
NAT10	SARC	chr11	34130376	34130376	A	G	Missense_Mutation		1
NAT10	SKCM	chr11	34156132	34156132	G	A	Splice_Site	p.G637_splice	1
NAT10	BLCA	chr11	34139990	34139990	G	A	Silent	p.E240E	1
NAT10	LGG	chr11	34160752	34160752	A	G	Silent	p.G742G	1
NAT10	SARC	chr11	34167679	34167679	G	T	Missense_Mutation	p.K1006N	1
NAT10	SKCM	chr11	34152965	34152965	C	T	Silent	p.I469I	1
NAT10	BLCA	chr11	34145364	34145364	G	A	Missense_Mutation		1
NAT10	CESC	chr11	34155888	34155888	C	T	Missense_Mutation	p.S586F	1
NAT10	BLCA	chr11	34129822	34129822	G	C	Missense_Mutation	p.G17A	1
NAT10	LIHC	chr11	34158558	34158558	T	C	Silent	p.Y732Y	1
NAT10	LUAD	chr11	34162089	34162089	G	-	Frame_Shift_Del	p.L854fs	1
NAT10	SKCM	chr11	34135386	34135386	G	A	Splice_Site	.	1
NAT10	LIHC	chr11	34152484	34152484	G	-	Splice_Site	p.A457_splice	1
NAT10	SARC	chr11	34144128	34144128	G	A	Silent		1
NAT10	SKCM	chr11	34135361	34135361	C	T	Silent	p.L157L	1
NAT10	BLCA	chr11	34139781	34139781	C	G	Silent		1
NAT10	BLCA	chr11	34153065	34153065	G	A	Missense_Mutation	p.E503K	1
NAT10	LGG	chr11	34152413	34152413	A	C	Missense_Mutation		1
NAT10	LUAD	chr11	34149145	34149145	G	T	Splice_Site	p.G415_splice	1
NAT10	SKCM	chr11	34158550	34158550	C	T	Missense_Mutation	p.P658S	1
NAT10	SKCM	chr11	34129796	34129796	C	T	Silent	p.N8N	1
NAT10	BLCA	chr11	34153065	34153065	G	A	Missense_Mutation		1
NAT10	COAD	chr11	34154602	34154602	C	T	Silent	p.S477S	1
NAT10	ESCA	chr11	34158541	34158541	G	T	Nonsense_Mutation	p.G727X	1
NAT10	UCEC	chr11	34130368	34130368	T	C	Missense_Mutation	p.L63P	1
NAT10	LIHC	chr11	34158255	34158255	A	G	Missense_Mutation	p.N699D	1
NAT10	LUSC	chr11	34152386	34152386	C	T	Missense_Mutation	p.S424F	1
NAT10	STAD	chr11	34137370	34137370	G	A	Splice_Site	p.D166_splice	1
NAT10	LIHC	chr11	34153697	34153697	T	-	Frame_Shift_Del	p.F516fs	1
NAT10	SARC	chr11	34129827	34129827	G	T	Missense_Mutation		1
NAT10	SKCM	chr11	34165011	34165011	G	A	Missense_Mutation	p.D969N	1
NAT10	BLCA	chr11	34139975	34139975	G	C	Silent		1
NAT10	BLCA	chr11	34156814	34156814	G	T	Missense_Mutation	p.Q668H	1
NAT10	LUAD	chr11	34144127	34144127	C	T	Missense_Mutation	p.A301V	1
NAT10	SKCM	chr11	34160824	34160824	C	T	Silent	p.A694A	1
NAT10	BLCA	chr11	34160786	34160786	G	A	Missense_Mutation		1
NAT10	COAD	chr11	34154645	34154645	C	T	Missense_Mutation	p.P492S	1
NAT10	STAD	chr11	34145925	34145925	G	A	Missense_Mutation	p.R362Q	1
NAT10	BLCA	chr11	34158254	34158254	G	C	Missense_Mutation	p.L698F	1
NAT10	ESCA	chr11	34160963	34160963	C	A	Silent	p.S780S	1
NAT10	LIHC	chr11	34152409	34152409	C	A	Missense_Mutation	p.R432S	1
NAT10	LUSC	chr11	34145879	34145879	C	A	Missense_Mutation	p.L347I	1
NAT10	SKCM	chr11	34133673	34133673	C	T	Missense_Mutation	p.P20L	1
NAT10	KIRP	chr11	34139959	34139959	C	A	Missense_Mutation		1
NAT10	SARC	chr11	34130366	34130366	G	T	Missense_Mutation		1
NAT10	SKCM	chr11	34155898	34155898	C	T	Silent	p.S589S	1
NAT10	BLCA	chr11	34130334	34130334	C	T	Missense_Mutation		1
NAT10	LGG	chr11	34160752	34160752	A	G	Silent		1
NAT10	LUAD	chr11	34144128	34144128	G	T	Silent	p.A301A	1
NAT10	SKCM	chr11	34152949	34152949	C	T	Missense_Mutation	p.S392F	1
NAT10	STAD	chr11	34137370	34137370	G	A	Missense_Mutation		1
NAT10	BLCA	chr11	34156814	34156814	G	T	Missense_Mutation		1
NAT10	COAD	chr11	34161970	34161970	G	A	Missense_Mutation	p.A743T	1
NAT10	SKCM	chr11	34162704	34162704	C	T	Silent	p.P815P	1
NAT10	THCA	chr11	34158572	34158572	C	A	Missense_Mutation		1
NAT10	BLCA	chr11	34167703	34167703	G	A	Silent	p.K1014K	1
NAT10	GBM	chr11	34129864	34129864	A	C	Missense_Mutation	p.D31A	1
NAT10	OV	chr11	34114772	34114772	G	A	Missense_Mutation		1
NAT10	LGG	chr11	34152413	34152413	A	C	Missense_Mutation	p.Q361P	1
NAT10	LIHC	chr11	34158219	34158219	C	-	Frame_Shift_Del	p.P687fs	1
NAT10	SARC	chr11	34154674	34154674	G	T	Silent		1
NAT10	SKCM	chr11	34145358	34145358	C	T	Silent	p.L322L	1
NAT10	BLCA	chr11	34129870	34129870	G	T	Missense_Mutation		1
NAT10	LUAD	chr11	34144129	34144129	G	T	Missense_Mutation	p.V302L	1
NAT10	SKCM	chr11	34152954	34152954	C	T	Nonsense_Mutation	p.Q394X	1
NAT10	STAD	chr11	34137370	34137370	G	A	Missense_Mutation	p.D166N	1
NAT10	COAD	chr11	34162057	34162057	G	A	Missense_Mutation	p.A772T	1
NAT10	SKCM	chr11	34152954	34152954	C	T	Nonsense_Mutation	p.Q466*	1
NAT10	THYM	chr11	34154645	34154645	C	T	Missense_Mutation		1
NAT10	BLCA	chr11	34153758	34153758	C	G	Missense_Mutation	p.S536C	1
NAT10	HNSC	chr11	34149130	34149130	G	A	Missense_Mutation		1
NAT10	LIHC	chr11	34145347	34145347	A	G	Missense_Mutation	p.N318S	1
NAT10	LGG	chr11	34162700	34162700	T	A	Missense_Mutation	p.L814Q	1
NAT10	SARC	chr11	34162086	34162086	G	T	Missense_Mutation		1
NAT10	SKCM	chr11	34133673	34133673	C	T	Missense_Mutation	p.P92L	1
NAT10	BLCA	chr11	34129822	34129822	G	C	Missense_Mutation		1
NAT10	LIHC	chr11	34149034	34149034	A	G	Missense_Mutation		1
NAT10	LUAD	chr11	34144053	34144053	G	A	Silent	p.L276L	1
NAT10	SKCM	chr11	34145400	34145400	C	T	Nonsense_Mutation	p.Q264X	1
NAT10	COAD	chr11	34167685	34167687	GAA	-	In_Frame_Del	p.1008_1009del	1
NAT10	SKCM	chr11	34152950	34152950	C	T	Silent	p.S464S	1
NAT10	BLCA	chr11	34162716	34162716	G	C	Missense_Mutation	p.L891F	1
NAT10	HNSC	chr11	34139817	34139817	G	A	Missense_Mutation		1
NAT10	LIHC	chr11	34129823	34129823	A	G	Silent	p.G17G	1
NAT10	PAAD	chr11	34165061	34165061	C	A	Silent		1
NAT10	LGG	chr11	34139764	34139764	G	A	Missense_Mutation	p.V127I	1
NAT10	LUAD	chr11	34149018	34149018	T	C	Silent	p.H372H	1
NAT10	SARC	chr11	34165066	34165066	G	T	Missense_Mutation		1
NAT10	SKCM	chr11	34160824	34160824	C	T	Silent	p.A766A	1
NAT10	THYM	chr11	34153037	34153037	T	A	Silent		1
NAT10	LIHC	chr11	34149040	34149040	G	A	Missense_Mutation		1
NAT10	SKCM	chr11	34156132	34156132	G	A	Missense_Mutation	p.G565E	1
NAT10	BLCA	chr11	34167637	34167637	G	A	Silent	p.K992K	1
NAT10	COAD	chr11	34167703	34167703	G	T	Missense_Mutation	p.K942N	1
NAT10	SKCM	chr11	34161016	34161016	G	A	Missense_Mutation	p.R798K	1
NAT10	BLCA	chr11	34139948	34139948	G	C	Missense_Mutation	p.E226D	1
NAT10	HNSC	chr11	34139817	34139817	G	A	Missense_Mutation	p.M216I	1
NAT10	LGG	chr11	34139764	34139764	G	A	Missense_Mutation	p.V199I	1
NAT10	SARC	chr11	34167679	34167679	G	T	Missense_Mutation		1
NAT10	SKCM	chr11	34158550	34158550	C	T	Missense_Mutation	p.P730S	1
NAT10	BLCA	chr11	34158254	34158254	G	C	Missense_Mutation		1
NAT10	THYM	chr11	34153697	34153697	T	C	Missense_Mutation	p.F516L	1
NAT10	LIHC	chr11	34167730	34167730	G	A	Silent		1
NAT10	SKCM	chr11	34152950	34152950	C	T	Silent	p.S392S	1
NAT10	BLCA	chr11	34139975	34139975	G	C	Silent	p.L235L	1
NAT10	COAD	chr11	34162752	34162752	G	A	Silent	p.V831V	1

Copy number variation (CNV) of NAT10
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across NAT10
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
23307	SARC	TCGA-DX-A6YS-01A	ADAM19	chr5	156933782	-	NAT10	chr11	34165074	-
23307	SARC	TCGA-DX-A6YS-01A	ADAM19	chr5	156934063	-	NAT10	chr11	34160115	-
23307	N/A	BQ027507	CSDE1	chr1	115259537	-	NAT10	chr11	34135187	+
74063	N/A	AW023035	NAT10	chr11	34168455	+	C9	chr5	39319135	-
71295	BRCA	TCGA-AN-A0XU-01A	NAT10	chr11	34130380	+	CAPRIN1	chr11	34118026	+
71295	OV	TCGA-13-1501-01A	NAT10	chr11	34127339	+	CAPRIN1	chr11	34118026	+
82394	SARC	TCGA-SI-A71Q-01A	NAT10	chr11	34145402	+	METTL15	chr11	28420335	+
98420	OV	TCGA-24-1425	NAT10	chr11	34133770	+	SLC3A2	chr11	62655606	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
THCA	NAT10	0.00513964821113072	0.14
TGCT	NAT10	0.00764490514971697	0.21
PAAD	NAT10	0.0113229639419555	0.29
KIRP	NAT10	0.0142144543589348	0.36
ESCA	NAT10	0.0247794772322616	0.59
CHOL	NAT10	0.048835457740859	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LGG	NAT10	0.00156535401011943	0.05
PRAD	NAT10	0.0369507021453072	1
PAAD	NAT10	0.0246632998995016	0.74
OV	NAT10	0.00162604760133096	0.05
ESCA	NAT10	0.000202824080633481	0.0067

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source