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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MRPL47 (NCBI Gene ID:57129)

Gene Summary

Gene Summary

Gene Information	Gene Name: MRPL47
	Gene ID: 57129
	Gene Symbol	MRPL47
	Gene ID	57129
	Gene Name	mitochondrial ribosomal protein L47
	Synonyms	CGI-204\|L47mt\|MRP-L47\|NCM1
	Cytomap	3q26.33
	Type of Gene	protein-coding
	Description	39S ribosomal protein L47, mitochondrialmitochondrial large ribosomal subunit protein uL29mnasopharyngeal carcinoma metastasis-related 1nasopharyngeal carcinoma metastasis-related protein 1
	Modification date	20200313
	UniProtAcc	Q9HD33

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0032543	Mitochondrial translation
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MRPL47	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'MRPL47[title] AND translation [title] AND human.'

Gene	Title	PMID
MRPL47	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000476781	179310431	179310527	In-frame
ENST00000476781	179316462	179316559	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000476781	179310431	179310527	1387	564	659	250	178	209

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q9HD33	178	209	176	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5OOM
Q9HD33	178	209	182	186	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5OOM
Q9HD33	178	209	188	190	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5OOM
Q9HD33	178	209	194	196	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5OOM
Q9HD33	178	209	206	237	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5OOM

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
ESCA	MRPL47	-2.26373711796715	0.001953125
COAD	MRPL47	-2.29582381838246	0.00863465666770936
STAD	MRPL47	-1.4008685687155	0.0118026207201183
LIHC	MRPL47	-6.59586850948538	0.0416658979324166
KIRC	MRPL47	1.74758475364701	1.00533732476669e-06
LUAD	MRPL47	-1.74990909879567	9.53955602455483e-07

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
STAD	MRPL47	hsa-miR-379-5p	91	0.308830149848865	0.00853563179443767

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LUSC	MRPL47	-0.147426627	0.023109465
STAD	MRPL47	-0.062391567	0.046447513

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MRPL47 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	MRPL47	ALG3	0.84225928	4.11E-13
DLBC	Cell metabolism gene	MRPL47	PPCDC	0.800148445	8.88E-12
DLBC	Cell metabolism gene	MRPL47	MIF	0.800311761	8.73E-12
DLBC	Cell metabolism gene	MRPL47	SNRPD1	0.801352235	7.84E-12
DLBC	Cell metabolism gene	MRPL47	DPM2	0.807383767	4.14E-12
DLBC	Cell metabolism gene	MRPL47	PSMC5	0.810143157	3.06E-12
DLBC	Cell metabolism gene	MRPL47	MTX1	0.813932172	2.01E-12
DLBC	Cell metabolism gene	MRPL47	PSMC1	0.814321342	1.93E-12
DLBC	Cell metabolism gene	MRPL47	PSMB7	0.814866133	1.81E-12
DLBC	Cell metabolism gene	MRPL47	DTYMK	0.818505333	1.20E-12
DLBC	Cell metabolism gene	MRPL47	PSMC3	0.8187565	1.16E-12
DLBC	Cell metabolism gene	MRPL47	FPGS	0.819323576	1.09E-12
DLBC	Cell metabolism gene	MRPL47	NME2	0.819730605	1.04E-12
DLBC	Cell metabolism gene	MRPL47	PSMD13	0.821691594	8.26E-13
DLBC	Cell metabolism gene	MRPL47	SNRPD3	0.822057206	7.91E-13
DLBC	Cell metabolism gene	MRPL47	PGP	0.827813775	3.97E-13
DLBC	Cell metabolism gene	MRPL47	TIMM8B	0.828588891	3.61E-13
DLBC	Cell metabolism gene	MRPL47	LSM5	0.831096014	2.65E-13
DLBC	Cell metabolism gene	MRPL47	POLR2L	0.835117939	1.59E-13
DLBC	Cell metabolism gene	MRPL47	SNRPD2	0.840333069	8.07E-14
DLBC	Cell metabolism gene	MRPL47	SNRPE	0.843478455	5.29E-14
DLBC	Cell metabolism gene	MRPL47	PSMB3	0.846415749	3.54E-14
DLBC	Cell metabolism gene	MRPL47	SEC61G	0.850781851	1.91E-14
DLBC	Cell metabolism gene	MRPL47	TIMM50	0.853196222	1.35E-14
DLBC	Cell metabolism gene	MRPL47	ATP5G1	0.856763431	7.99E-15
DLBC	Cell metabolism gene	MRPL47	PMPCA	0.870316963	9.46E-16
DLBC	Cell metabolism gene	MRPL47	TIMM13	0.87196567	7.18E-16
DLBC	Cell metabolism gene	MRPL47	POLR2I	0.873015974	6.01E-16
DLBC	Cell metabolism gene	MRPL47	POLR2H	0.877617264	2.71E-16
DLBC	Cell metabolism gene	MRPL47	POLR2F	0.88343612	9.43E-17
DLBC	Cell metabolism gene	MRPL47	LSM3	0.88477051	7.34E-17
DLBC	CGC	MRPL47	U2AF1	0.805386641	5.12E-12
DLBC	Epifactor	MRPL47	FBL	0.81789581	1.28E-12
DLBC	Epifactor	MRPL47	RBX1	0.830189595	2.96E-13
DLBC	TF	MRPL47	NME2	0.819730605	1.04E-12
DLBC	TSG	MRPL47	PARK7	0.839853233	8.59E-14
DLBC	TSG	MRPL47	PHB	0.847646799	2.98E-14
DLBC	TSG	MRPL47	GADD45GIP1	0.858654433	6.02E-15
ESCA	Epifactor	MRPL47	ACTL6A	0.823868706	1.01E-49
GBM	Cell metabolism gene	MRPL47	PSMD14	0.806405903	1.24E-40
GBM	IUPHAR	MRPL47	PSMD14	0.806405903	1.24E-40
HNSC	Cell metabolism gene	MRPL47	POLR2H	0.83701482	8.10E-150
LUAD	Epifactor	MRPL47	ACTL6A	0.803458516	2.19E-131
LUSC	Cell metabolism gene	MRPL47	DNAJC19	0.812443184	3.32E-131
LUSC	Cell metabolism gene	MRPL47	POLR2H	0.841683398	1.39E-149
LUSC	Epifactor	MRPL47	ACTL6A	0.907446504	1.20E-209
LUSC	IUPHAR	MRPL47	MFN1	0.818007155	1.91E-134
LUSC	TF	MRPL47	ZNF639	0.824162014	3.68E-138
TGCT	Cell metabolism gene	MRPL47	DNAJC19	0.822899142	1.21E-39
TGCT	Cell metabolism gene	MRPL47	POLR2H	0.825734441	3.92E-40
THYM	Cell metabolism gene	MRPL47	ACTB	0.80008353	2.11E-28
THYM	Cell metabolism gene	MRPL47	POLD2	0.801816577	1.32E-28
THYM	Cell metabolism gene	MRPL47	APOA1	0.804246851	6.83E-29
THYM	Cell metabolism gene	MRPL47	EXOSC5	0.804355212	6.63E-29
THYM	Cell metabolism gene	MRPL47	PSMB1	0.804782878	5.89E-29
THYM	Cell metabolism gene	MRPL47	ZNRD1	0.806407488	3.76E-29
THYM	Cell metabolism gene	MRPL47	PSMB8	0.808186237	2.29E-29
THYM	Cell metabolism gene	MRPL47	DUT	0.808411966	2.15E-29
THYM	Cell metabolism gene	MRPL47	NME1	0.810398647	1.22E-29
THYM	Cell metabolism gene	MRPL47	ITPA	0.811074288	1.01E-29
THYM	Cell metabolism gene	MRPL47	NOP56	0.813848168	4.54E-30
THYM	Cell metabolism gene	MRPL47	TAZ	0.814424935	3.84E-30
THYM	Cell metabolism gene	MRPL47	PSMB2	0.81513804	3.12E-30
THYM	Cell metabolism gene	MRPL47	TSTA3	0.817405657	1.60E-30
THYM	Cell metabolism gene	MRPL47	TK1	0.81849354	1.16E-30
THYM	Cell metabolism gene	MRPL47	HSD17B10	0.821105308	5.26E-31
THYM	Cell metabolism gene	MRPL47	TOMM22	0.821385632	4.83E-31
THYM	Cell metabolism gene	MRPL47	GEMIN7	0.821664178	4.44E-31
THYM	Cell metabolism gene	MRPL47	TIMM13	0.821734379	4.35E-31
THYM	Cell metabolism gene	MRPL47	SLC27A5	0.824722776	1.73E-31
THYM	Cell metabolism gene	MRPL47	GALK1	0.826324612	1.05E-31
THYM	Cell metabolism gene	MRPL47	PSME2	0.826518085	9.89E-32
THYM	Cell metabolism gene	MRPL47	PSMB4	0.828040563	6.12E-32
THYM	Cell metabolism gene	MRPL47	APRT	0.828098192	6.01E-32
THYM	Cell metabolism gene	MRPL47	POLR3K	0.828354013	5.54E-32
THYM	Cell metabolism gene	MRPL47	PSMB6	0.828611214	5.10E-32
THYM	Cell metabolism gene	MRPL47	PSMA5	0.828820785	4.77E-32
THYM	Cell metabolism gene	MRPL47	PGP	0.833143704	1.18E-32
THYM	Cell metabolism gene	MRPL47	PSMC1	0.837190361	3.07E-33
THYM	Cell metabolism gene	MRPL47	PFDN4	0.839401824	1.45E-33
THYM	Cell metabolism gene	MRPL47	TIMM50	0.839852511	1.24E-33
THYM	Cell metabolism gene	MRPL47	SNRPD3	0.841935309	6.04E-34
THYM	Cell metabolism gene	MRPL47	PSMD4	0.847104575	9.67E-35
THYM	Cell metabolism gene	MRPL47	PSME1	0.847275217	9.09E-35
THYM	Cell metabolism gene	MRPL47	TBCB	0.847307259	8.98E-35
THYM	Cell metabolism gene	MRPL47	POLR2J	0.849372915	4.23E-35
THYM	Cell metabolism gene	MRPL47	NT5M	0.850637385	2.66E-35
THYM	Cell metabolism gene	MRPL47	GUK1	0.851401953	2.00E-35
THYM	Cell metabolism gene	MRPL47	WBSCR22	0.85737851	2.05E-36
THYM	Cell metabolism gene	MRPL47	TOMM5	0.858638475	1.25E-36
THYM	Cell metabolism gene	MRPL47	LSM2	0.858789979	1.18E-36
THYM	Cell metabolism gene	MRPL47	GEMIN6	0.863465739	1.81E-37
THYM	Cell metabolism gene	MRPL47	PSMC3	0.864577114	1.15E-37
THYM	Cell metabolism gene	MRPL47	PFDN6	0.866930276	4.31E-38
THYM	Cell metabolism gene	MRPL47	ACOT8	0.868423059	2.30E-38
THYM	Cell metabolism gene	MRPL47	DTYMK	0.870420335	9.75E-39
THYM	Cell metabolism gene	MRPL47	PSMB10	0.872118552	4.66E-39
THYM	Cell metabolism gene	MRPL47	SNRPE	0.874008993	2.02E-39
THYM	Cell metabolism gene	MRPL47	TOMM40	0.874398938	1.70E-39
THYM	Cell metabolism gene	MRPL47	EXOSC1	0.875171214	1.20E-39
THYM	Cell metabolism gene	MRPL47	COX17	0.875834006	8.91E-40
THYM	Cell metabolism gene	MRPL47	PSMB7	0.876201884	7.54E-40
THYM	Cell metabolism gene	MRPL47	SEC61B	0.877199866	4.78E-40
THYM	Cell metabolism gene	MRPL47	PHKG2	0.877958465	3.38E-40
THYM	Cell metabolism gene	MRPL47	SNRPG	0.87849214	2.64E-40
THYM	Cell metabolism gene	MRPL47	TIMM17B	0.878761715	2.33E-40
THYM	Cell metabolism gene	MRPL47	SEC61G	0.879453642	1.69E-40
THYM	Cell metabolism gene	MRPL47	SNRPD1	0.883310651	2.70E-41
THYM	Cell metabolism gene	MRPL47	TIMM8B	0.883680933	2.26E-41
THYM	Cell metabolism gene	MRPL47	LSM3	0.883697699	2.24E-41
THYM	Cell metabolism gene	MRPL47	PSMD13	0.886940881	4.53E-42
THYM	Cell metabolism gene	MRPL47	POLR2H	0.887543068	3.35E-42
THYM	Cell metabolism gene	MRPL47	PSMB3	0.888328427	2.25E-42
THYM	Cell metabolism gene	MRPL47	DGUOK	0.888600692	1.96E-42
THYM	Cell metabolism gene	MRPL47	SNRPD2	0.894237482	1.04E-43
THYM	Cell metabolism gene	MRPL47	PSMA6	0.894624219	8.41E-44
THYM	Cell metabolism gene	MRPL47	SNRPB	0.895405307	5.51E-44
THYM	Cell metabolism gene	MRPL47	EBP	0.897019463	2.28E-44
THYM	Cell metabolism gene	MRPL47	PAFAH1B3	0.911682489	3.54E-48
THYM	Cell metabolism gene	MRPL47	SNRPF	0.916545648	1.37E-49
THYM	Cell metabolism gene	MRPL47	PSMA4	0.919218827	2.11E-50
THYM	Cell metabolism gene	MRPL47	LSM4	0.922550658	1.86E-51
THYM	Cell metabolism gene	MRPL47	TXN	0.927196633	5.23E-53
THYM	Cell metabolism gene	MRPL47	LSM5	0.92881645	1.42E-53
THYM	CGC	MRPL47	BCL2L12	0.80149264	1.45E-28
THYM	CGC	MRPL47	SDHAF2	0.840149032	1.12E-33
THYM	CGC	MRPL47	RECQL4	0.846268034	1.31E-34
THYM	CGC	MRPL47	H3F3A	0.860550362	5.87E-37
THYM	CGC	MRPL47	TFPT	0.860619166	5.72E-37
THYM	CGC	MRPL47	COX6C	0.897918698	1.38E-44
THYM	Epifactor	MRPL47	ACTB	0.80008353	2.11E-28
THYM	Epifactor	MRPL47	SIRT7	0.801922505	1.29E-28
THYM	Epifactor	MRPL47	TRIM28	0.802475405	1.11E-28
THYM	Epifactor	MRPL47	EXOSC5	0.804355212	6.63E-29
THYM	Epifactor	MRPL47	MAZ	0.80592537	4.30E-29
THYM	Epifactor	MRPL47	ZGPAT	0.808884689	1.88E-29
THYM	Epifactor	MRPL47	PRPF31	0.80993465	1.40E-29
THYM	Epifactor	MRPL47	HIST1H2BH	0.810532439	1.18E-29
THYM	Epifactor	MRPL47	NAP1L4	0.824067646	2.12E-31
THYM	Epifactor	MRPL47	PRR14	0.827031193	8.42E-32
THYM	Epifactor	MRPL47	HIST1H2AJ	0.827088088	8.27E-32
THYM	Epifactor	MRPL47	INO80E	0.829198109	4.23E-32
THYM	Epifactor	MRPL47	SUV39H1	0.835308557	5.77E-33
THYM	Epifactor	MRPL47	H2AFX	0.83587797	4.77E-33
THYM	Epifactor	MRPL47	SIRT6	0.844253848	2.68E-34
THYM	Epifactor	MRPL47	PPM1G	0.847359981	8.81E-35
THYM	Epifactor	MRPL47	DPY30	0.851664735	1.81E-35
THYM	Epifactor	MRPL47	ZNHIT1	0.852232581	1.47E-35
THYM	Epifactor	MRPL47	ENY2	0.859137347	1.03E-36
THYM	Epifactor	MRPL47	H3F3A	0.860550362	5.87E-37
THYM	Epifactor	MRPL47	TFPT	0.860619166	5.72E-37
THYM	Epifactor	MRPL47	CDK5	0.86160454	3.85E-37
THYM	Epifactor	MRPL47	BRMS1	0.866052839	6.23E-38
THYM	Epifactor	MRPL47	SS18L2	0.868309115	2.41E-38
THYM	Epifactor	MRPL47	TAF10	0.87112164	7.20E-39
THYM	Epifactor	MRPL47	PPP4C	0.87252339	3.90E-39
THYM	Epifactor	MRPL47	EXOSC1	0.875171214	1.20E-39
THYM	Epifactor	MRPL47	RBX1	0.878248972	2.95E-40
THYM	Epifactor	MRPL47	RUVBL2	0.880921803	8.47E-41
THYM	Epifactor	MRPL47	HIST2H2AC	0.881455263	6.57E-41
THYM	IUPHAR	MRPL47	SIRT7	0.801922505	1.29E-28
THYM	IUPHAR	MRPL47	TOP1MT	0.802267264	1.17E-28
THYM	IUPHAR	MRPL47	TRIM28	0.802475405	1.11E-28
THYM	IUPHAR	MRPL47	PSMB1	0.804782878	5.89E-29
THYM	IUPHAR	MRPL47	PSMB8	0.808186237	2.29E-29
THYM	IUPHAR	MRPL47	PSMB2	0.81513804	3.12E-30
THYM	IUPHAR	MRPL47	SLC27A5	0.824722776	1.73E-31
THYM	IUPHAR	MRPL47	PSMB6	0.828611214	5.10E-32
THYM	IUPHAR	MRPL47	UCHL3	0.828693733	4.97E-32
THYM	IUPHAR	MRPL47	SUV39H1	0.835308557	5.77E-33
THYM	IUPHAR	MRPL47	BIRC5	0.843094095	4.03E-34
THYM	IUPHAR	MRPL47	SIRT6	0.844253848	2.68E-34
THYM	IUPHAR	MRPL47	NT5M	0.850637385	2.66E-35
THYM	IUPHAR	MRPL47	DYRK4	0.855518867	4.21E-36
THYM	IUPHAR	MRPL47	CDK5	0.86160454	3.85E-37
THYM	IUPHAR	MRPL47	PHKG2	0.877958465	3.38E-40
THYM	IUPHAR	MRPL47	PPIA	0.924069476	5.93E-52
THYM	Kinase	MRPL47	TRIM28	0.802475405	1.11E-28
THYM	Kinase	MRPL47	DYRK4	0.855518867	4.21E-36
THYM	Kinase	MRPL47	CDK5	0.86160454	3.85E-37
THYM	Kinase	MRPL47	PHKG2	0.877958465	3.38E-40
THYM	TF	MRPL47	MAZ	0.80592537	4.30E-29
THYM	TF	MRPL47	ZGPAT	0.808884689	1.88E-29
THYM	TF	MRPL47	ZNF428	0.809800799	1.45E-29
THYM	TF	MRPL47	ETV2	0.815210937	3.05E-30
THYM	TF	MRPL47	ZNF668	0.818708507	1.08E-30
THYM	TF	MRPL47	E2F1	0.823991902	2.17E-31
THYM	TF	MRPL47	ZNF688	0.824504855	1.85E-31
THYM	TF	MRPL47	RBCK1	0.84768504	7.84E-35
THYM	TF	MRPL47	PIN1	0.848136459	6.65E-35
THYM	TF	MRPL47	MYPOP	0.850939308	2.37E-35
THYM	TF	MRPL47	MXD3	0.858868236	1.14E-36
THYM	TF	MRPL47	DNTTIP1	0.861218185	4.50E-37
THYM	TF	MRPL47	USF1	0.864189682	1.35E-37
THYM	TF	MRPL47	ZNF444	0.881674539	5.92E-41
THYM	TF	MRPL47	THYN1	0.884429818	1.57E-41
THYM	TF	MRPL47	DRAP1	0.896009897	3.96E-44
THYM	TF	MRPL47	GTF3A	0.901238871	2.10E-45
THYM	TSG	MRPL47	NME1	0.810398647	1.22E-29
THYM	TSG	MRPL47	AIP	0.818090731	1.30E-30
THYM	TSG	MRPL47	ZNF668	0.818708507	1.08E-30
THYM	TSG	MRPL47	E2F1	0.823991902	2.17E-31
THYM	TSG	MRPL47	NPRL2	0.825092888	1.54E-31
THYM	TSG	MRPL47	H2AFX	0.83587797	4.77E-33
THYM	TSG	MRPL47	SIRT6	0.844253848	2.68E-34
THYM	TSG	MRPL47	HTRA2	0.844744135	2.25E-34
THYM	TSG	MRPL47	PIN1	0.848136459	6.65E-35
THYM	TSG	MRPL47	PFN1	0.851072972	2.26E-35
THYM	TSG	MRPL47	BRMS1	0.866052839	6.23E-38
UCEC	Cell metabolism gene	MRPL47	ALG3	0.807307015	1.83E-47
UCEC	Cell metabolism gene	MRPL47	POLR2H	0.83881255	1.90E-54
UCS	Cell metabolism gene	MRPL47	ACTB	0.80008353	2.11E-28
UCS	Cell metabolism gene	MRPL47	POLD2	0.801816577	1.32E-28
UCS	Cell metabolism gene	MRPL47	APOA1	0.804246851	6.83E-29
UCS	Cell metabolism gene	MRPL47	EXOSC5	0.804355212	6.63E-29
UCS	Cell metabolism gene	MRPL47	PSMB1	0.804782878	5.89E-29
UCS	Cell metabolism gene	MRPL47	ZNRD1	0.806407488	3.76E-29
UCS	Cell metabolism gene	MRPL47	PSMB8	0.808186237	2.29E-29
UCS	Cell metabolism gene	MRPL47	DUT	0.808411966	2.15E-29
UCS	Cell metabolism gene	MRPL47	NME1	0.810398647	1.22E-29
UCS	Cell metabolism gene	MRPL47	ITPA	0.811074288	1.01E-29
UCS	Cell metabolism gene	MRPL47	NOP56	0.813848168	4.54E-30
UCS	Cell metabolism gene	MRPL47	TAZ	0.814424935	3.84E-30
UCS	Cell metabolism gene	MRPL47	PSMB2	0.81513804	3.12E-30
UCS	Cell metabolism gene	MRPL47	TSTA3	0.817405657	1.60E-30
UCS	Cell metabolism gene	MRPL47	TK1	0.81849354	1.16E-30
UCS	Cell metabolism gene	MRPL47	HSD17B10	0.821105308	5.26E-31
UCS	Cell metabolism gene	MRPL47	TOMM22	0.821385632	4.83E-31
UCS	Cell metabolism gene	MRPL47	GEMIN7	0.821664178	4.44E-31
UCS	Cell metabolism gene	MRPL47	TIMM13	0.821734379	4.35E-31
UCS	Cell metabolism gene	MRPL47	SLC27A5	0.824722776	1.73E-31
UCS	Cell metabolism gene	MRPL47	GALK1	0.826324612	1.05E-31
UCS	Cell metabolism gene	MRPL47	PSME2	0.826518085	9.89E-32
UCS	Cell metabolism gene	MRPL47	PSMB4	0.828040563	6.12E-32
UCS	Cell metabolism gene	MRPL47	APRT	0.828098192	6.01E-32
UCS	Cell metabolism gene	MRPL47	POLR3K	0.828354013	5.54E-32
UCS	Cell metabolism gene	MRPL47	PSMB6	0.828611214	5.10E-32
UCS	Cell metabolism gene	MRPL47	PSMA5	0.828820785	4.77E-32
UCS	Cell metabolism gene	MRPL47	PGP	0.833143704	1.18E-32
UCS	Cell metabolism gene	MRPL47	PSMC1	0.837190361	3.07E-33
UCS	Cell metabolism gene	MRPL47	PFDN4	0.839401824	1.45E-33
UCS	Cell metabolism gene	MRPL47	TIMM50	0.839852511	1.24E-33
UCS	Cell metabolism gene	MRPL47	SNRPD3	0.841935309	6.04E-34
UCS	Cell metabolism gene	MRPL47	PSMD4	0.847104575	9.67E-35
UCS	Cell metabolism gene	MRPL47	PSME1	0.847275217	9.09E-35
UCS	Cell metabolism gene	MRPL47	TBCB	0.847307259	8.98E-35
UCS	Cell metabolism gene	MRPL47	POLR2J	0.849372915	4.23E-35
UCS	Cell metabolism gene	MRPL47	NT5M	0.850637385	2.66E-35
UCS	Cell metabolism gene	MRPL47	GUK1	0.851401953	2.00E-35
UCS	Cell metabolism gene	MRPL47	WBSCR22	0.85737851	2.05E-36
UCS	Cell metabolism gene	MRPL47	TOMM5	0.858638475	1.25E-36
UCS	Cell metabolism gene	MRPL47	LSM2	0.858789979	1.18E-36
UCS	Cell metabolism gene	MRPL47	GEMIN6	0.863465739	1.81E-37
UCS	Cell metabolism gene	MRPL47	PSMC3	0.864577114	1.15E-37
UCS	Cell metabolism gene	MRPL47	PFDN6	0.866930276	4.31E-38
UCS	Cell metabolism gene	MRPL47	ACOT8	0.868423059	2.30E-38
UCS	Cell metabolism gene	MRPL47	DTYMK	0.870420335	9.75E-39
UCS	Cell metabolism gene	MRPL47	PSMB10	0.872118552	4.66E-39
UCS	Cell metabolism gene	MRPL47	SNRPE	0.874008993	2.02E-39
UCS	Cell metabolism gene	MRPL47	TOMM40	0.874398938	1.70E-39
UCS	Cell metabolism gene	MRPL47	EXOSC1	0.875171214	1.20E-39
UCS	Cell metabolism gene	MRPL47	COX17	0.875834006	8.91E-40
UCS	Cell metabolism gene	MRPL47	PSMB7	0.876201884	7.54E-40
UCS	Cell metabolism gene	MRPL47	SEC61B	0.877199866	4.78E-40
UCS	Cell metabolism gene	MRPL47	PHKG2	0.877958465	3.38E-40
UCS	Cell metabolism gene	MRPL47	SNRPG	0.87849214	2.64E-40
UCS	Cell metabolism gene	MRPL47	TIMM17B	0.878761715	2.33E-40
UCS	Cell metabolism gene	MRPL47	SEC61G	0.879453642	1.69E-40
UCS	Cell metabolism gene	MRPL47	SNRPD1	0.883310651	2.70E-41
UCS	Cell metabolism gene	MRPL47	TIMM8B	0.883680933	2.26E-41
UCS	Cell metabolism gene	MRPL47	LSM3	0.883697699	2.24E-41
UCS	Cell metabolism gene	MRPL47	PSMD13	0.886940881	4.53E-42
UCS	Cell metabolism gene	MRPL47	POLR2H	0.887543068	3.35E-42
UCS	Cell metabolism gene	MRPL47	PSMB3	0.888328427	2.25E-42
UCS	Cell metabolism gene	MRPL47	DGUOK	0.888600692	1.96E-42
UCS	Cell metabolism gene	MRPL47	SNRPD2	0.894237482	1.04E-43
UCS	Cell metabolism gene	MRPL47	PSMA6	0.894624219	8.41E-44
UCS	Cell metabolism gene	MRPL47	SNRPB	0.895405307	5.51E-44
UCS	Cell metabolism gene	MRPL47	EBP	0.897019463	2.28E-44
UCS	Cell metabolism gene	MRPL47	PAFAH1B3	0.911682489	3.54E-48
UCS	Cell metabolism gene	MRPL47	SNRPF	0.916545648	1.37E-49
UCS	Cell metabolism gene	MRPL47	PSMA4	0.919218827	2.11E-50
UCS	Cell metabolism gene	MRPL47	LSM4	0.922550658	1.86E-51
UCS	Cell metabolism gene	MRPL47	TXN	0.927196633	5.23E-53
UCS	Cell metabolism gene	MRPL47	LSM5	0.92881645	1.42E-53
UCS	CGC	MRPL47	BCL2L12	0.80149264	1.45E-28
UCS	CGC	MRPL47	SDHAF2	0.840149032	1.12E-33
UCS	CGC	MRPL47	RECQL4	0.846268034	1.31E-34
UCS	CGC	MRPL47	H3F3A	0.860550362	5.87E-37
UCS	CGC	MRPL47	TFPT	0.860619166	5.72E-37
UCS	CGC	MRPL47	COX6C	0.897918698	1.38E-44
UCS	Epifactor	MRPL47	ACTB	0.80008353	2.11E-28
UCS	Epifactor	MRPL47	SIRT7	0.801922505	1.29E-28
UCS	Epifactor	MRPL47	TRIM28	0.802475405	1.11E-28
UCS	Epifactor	MRPL47	EXOSC5	0.804355212	6.63E-29
UCS	Epifactor	MRPL47	MAZ	0.80592537	4.30E-29
UCS	Epifactor	MRPL47	ZGPAT	0.808884689	1.88E-29
UCS	Epifactor	MRPL47	PRPF31	0.80993465	1.40E-29
UCS	Epifactor	MRPL47	HIST1H2BH	0.810532439	1.18E-29
UCS	Epifactor	MRPL47	NAP1L4	0.824067646	2.12E-31
UCS	Epifactor	MRPL47	PRR14	0.827031193	8.42E-32
UCS	Epifactor	MRPL47	HIST1H2AJ	0.827088088	8.27E-32
UCS	Epifactor	MRPL47	INO80E	0.829198109	4.23E-32
UCS	Epifactor	MRPL47	SUV39H1	0.835308557	5.77E-33
UCS	Epifactor	MRPL47	H2AFX	0.83587797	4.77E-33
UCS	Epifactor	MRPL47	SIRT6	0.844253848	2.68E-34
UCS	Epifactor	MRPL47	PPM1G	0.847359981	8.81E-35
UCS	Epifactor	MRPL47	DPY30	0.851664735	1.81E-35
UCS	Epifactor	MRPL47	ZNHIT1	0.852232581	1.47E-35
UCS	Epifactor	MRPL47	ENY2	0.859137347	1.03E-36
UCS	Epifactor	MRPL47	H3F3A	0.860550362	5.87E-37
UCS	Epifactor	MRPL47	TFPT	0.860619166	5.72E-37
UCS	Epifactor	MRPL47	CDK5	0.86160454	3.85E-37
UCS	Epifactor	MRPL47	BRMS1	0.866052839	6.23E-38
UCS	Epifactor	MRPL47	SS18L2	0.868309115	2.41E-38
UCS	Epifactor	MRPL47	TAF10	0.87112164	7.20E-39
UCS	Epifactor	MRPL47	PPP4C	0.87252339	3.90E-39
UCS	Epifactor	MRPL47	EXOSC1	0.875171214	1.20E-39
UCS	Epifactor	MRPL47	RBX1	0.878248972	2.95E-40
UCS	Epifactor	MRPL47	RUVBL2	0.880921803	8.47E-41
UCS	Epifactor	MRPL47	HIST2H2AC	0.881455263	6.57E-41
UCS	IUPHAR	MRPL47	SIRT7	0.801922505	1.29E-28
UCS	IUPHAR	MRPL47	TOP1MT	0.802267264	1.17E-28
UCS	IUPHAR	MRPL47	TRIM28	0.802475405	1.11E-28
UCS	IUPHAR	MRPL47	PSMB1	0.804782878	5.89E-29
UCS	IUPHAR	MRPL47	PSMB8	0.808186237	2.29E-29
UCS	IUPHAR	MRPL47	PSMB2	0.81513804	3.12E-30
UCS	IUPHAR	MRPL47	SLC27A5	0.824722776	1.73E-31
UCS	IUPHAR	MRPL47	PSMB6	0.828611214	5.10E-32
UCS	IUPHAR	MRPL47	UCHL3	0.828693733	4.97E-32
UCS	IUPHAR	MRPL47	SUV39H1	0.835308557	5.77E-33
UCS	IUPHAR	MRPL47	BIRC5	0.843094095	4.03E-34
UCS	IUPHAR	MRPL47	SIRT6	0.844253848	2.68E-34
UCS	IUPHAR	MRPL47	NT5M	0.850637385	2.66E-35
UCS	IUPHAR	MRPL47	DYRK4	0.855518867	4.21E-36
UCS	IUPHAR	MRPL47	CDK5	0.86160454	3.85E-37
UCS	IUPHAR	MRPL47	PHKG2	0.877958465	3.38E-40
UCS	IUPHAR	MRPL47	PPIA	0.924069476	5.93E-52
UCS	Kinase	MRPL47	TRIM28	0.802475405	1.11E-28
UCS	Kinase	MRPL47	DYRK4	0.855518867	4.21E-36
UCS	Kinase	MRPL47	CDK5	0.86160454	3.85E-37
UCS	Kinase	MRPL47	PHKG2	0.877958465	3.38E-40
UCS	TF	MRPL47	MAZ	0.80592537	4.30E-29
UCS	TF	MRPL47	ZGPAT	0.808884689	1.88E-29
UCS	TF	MRPL47	ZNF428	0.809800799	1.45E-29
UCS	TF	MRPL47	ETV2	0.815210937	3.05E-30
UCS	TF	MRPL47	ZNF668	0.818708507	1.08E-30
UCS	TF	MRPL47	E2F1	0.823991902	2.17E-31
UCS	TF	MRPL47	ZNF688	0.824504855	1.85E-31
UCS	TF	MRPL47	RBCK1	0.84768504	7.84E-35
UCS	TF	MRPL47	PIN1	0.848136459	6.65E-35
UCS	TF	MRPL47	MYPOP	0.850939308	2.37E-35
UCS	TF	MRPL47	MXD3	0.858868236	1.14E-36
UCS	TF	MRPL47	DNTTIP1	0.861218185	4.50E-37
UCS	TF	MRPL47	USF1	0.864189682	1.35E-37
UCS	TF	MRPL47	ZNF444	0.881674539	5.92E-41
UCS	TF	MRPL47	THYN1	0.884429818	1.57E-41
UCS	TF	MRPL47	DRAP1	0.896009897	3.96E-44
UCS	TF	MRPL47	GTF3A	0.901238871	2.10E-45
UCS	TSG	MRPL47	NME1	0.810398647	1.22E-29
UCS	TSG	MRPL47	AIP	0.818090731	1.30E-30
UCS	TSG	MRPL47	ZNF668	0.818708507	1.08E-30
UCS	TSG	MRPL47	E2F1	0.823991902	2.17E-31
UCS	TSG	MRPL47	NPRL2	0.825092888	1.54E-31
UCS	TSG	MRPL47	H2AFX	0.83587797	4.77E-33
UCS	TSG	MRPL47	SIRT6	0.844253848	2.68E-34
UCS	TSG	MRPL47	HTRA2	0.844744135	2.25E-34
UCS	TSG	MRPL47	PIN1	0.848136459	6.65E-35
UCS	TSG	MRPL47	PFN1	0.851072972	2.26E-35
UCS	TSG	MRPL47	BRMS1	0.866052839	6.23E-38

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
BRCA	MRPL47	MRPL32	-3.7979134181794	0.000134327661287861
STAD	MRPL47	MRPL15	-2.15546608137429	0.000334546435624361
LUSC	MRPL47	MRPL44	-1.0353261138043	0.000533204507372277
LIHC	MRPL47	MRPL13	1.54402472107614	0.000655351190157038
LUAD	MRPL47	MRPL32	-2.1966239418264	0.00121089428940613
BLCA	MRPL47	MRPL27	-4.19270554058168	0.00202178955078125
CHOL	MRPL47	MRPL3	-2.68429255990621	0.00390625
ESCA	MRPL47	MRPL3	-4.97897094908275	0.0048828125
COAD	MRPL47	MRPL15	1.17181689924568	0.00513318181037904
ESCA	MRPL47	MRPL13	-1.07746088474995	0.0068359375
ESCA	MRPL47	MRPL17	-1.18756178214998	0.009765625
CHOL	MRPL47	MRPL44	-1.84100898736725	0.01171875
LIHC	MRPL47	MRPL17	-1.06225729770915	0.0124123499319886
STAD	MRPL47	MRPL4	1.4393539135682	0.0279771662317216
KIRC	MRPL47	MRPL32	-2.79664327578899	0.0376051795400881
BRCA	MRPL47	MRPL27	-1.5584165725499	1.16393956539382e-08
KICH	MRPL47	MRPL15	1.54522142310359	1.19209289550781e-07
STAD	MRPL47	MRPL17	-3.90880705449186	1.49570405483246e-06
KIRP	MRPL47	MRPL49	-2.36524030474784	1.53668224811554e-08
LUSC	MRPL47	MRPL15	-4.43702988385305	1.91594862886626e-08
KIRC	MRPL47	MRPL3	1.69955762234244	1.97132191719422e-08
LIHC	MRPL47	MRPL32	-1.20074144698753	2.24402029682138e-06
COAD	MRPL47	MRPL4	2.77705897514473	2.98023223876954e-07
BRCA	MRPL47	MRPL44	-2.66444869593332	3.06751315169682e-08
LUAD	MRPL47	MRPL27	-1.39404329671842	3.44055922076328e-05
LUSC	MRPL47	MRPL27	-1.81809468729316	3.90393047420304e-06
THCA	MRPL47	MRPL49	-1.28871899028168	5.42468304941934e-06
BRCA	MRPL47	MRPL15	-3.82448964360727	5.49451113259074e-14
LUAD	MRPL47	MRPL44	-3.23791370825974	5.91982739853218e-07
LUSC	MRPL47	MRPL17	-6.83409683292749	6.93230040561614e-07

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MRPL47

ICT1, Ybx1, MRPL50, MRPL44, MRPL43, MRPL45, TSR1, ACTA2, LAMTOR3, CLPTM1L, GRSF1, BTRC, RPL13, MRPL28, RPL6, NIFK, MRPS18A, RPS8, MRPL4, HNRNPA1, MRPL39, MRPL37, MRPS30, MRPL12, MRPL46, MRPL9, RPL26L1, MRPL32, MRPL11, MRPL48, MRPL40, MRPL3, MRPL1, MRPL23, MRPL41, MRPL22, MRPL10, MRPL24, MRPL49, MRPL38, MRPL20, GRAMD1A, MRPL27, MRPL55, MALSU1, MRPL16, MRPL19, MRPL15, MRPL2, MRPL21, MRPL13, MRPL17, MRPL33, GADD45GIP1, MRPL35, MRPL30, MRPL18, MRPL14, MRPL42, RNMTL1, MRPL51, MRPL57, MRPL34, C1qbp, Ddb1, Tgs1, Kif19a, Brwd3, POU5F1, CDC14B, PDGFB, RPL18, ZNF324B, ZNF331, CYLD, PYHIN1, EFTUD2, LARP7, MB21D1, FBL, BET1, RPS6, MRM1, HSPD1, PDK1, TRMT61B, AURKAIP1, RC3H2, SNRNP70, NFX1, PLEKHA4, PRKCI, PTPN12, PDIA3, ESR1, HTRA2, IMMP2L, ERCC6, XRN2, CIT, KIF14, DOCK3, ACAD9, AUH, C12orf65, C17orf80, C1QBP, C21orf33, C6orf203, MCUR1, CCDC90B, CHCHD1, CS, FASTKD3, FASTKD5, GFM1, GFM2, HINT2, LRPPRC, CCDC109B, MDH2, METTL15, METTL17, MRPS12, MRPS26, MRRF, MTERF3, MTG2, MTIF2, MTIF3, MTRF1, MTRF1L, NGRN, PMPCA, PMPCB, RPUSD3, RPUSD4, SLIRP, SSBP1, TACO1, TBRG4, TEFM, TFAM, TRUB2, TSFM, TUFM, VWA8, EXD2, CLPP, MAFB, Apc2, DNAJC15, HSCB, SMYD3, C14orf169, ZWINT, RPL27A, RPL17, HNRNPU, RPL19, RPL26, FAM120A, RPL37, SRSF3, PRR3, SRSF6, LIN28A, RBMS2, ABT1, MRPL52, SRSF4, H1FNT, ZBTB47, YBX1, SRSF5, MRPL53, YBX2, RPL13A, ZNF485, NEIL1, HIST1H2AM, RPL10, APOBEC3D, RPL35, FAHD1, KLF12, KLF15, BRD4,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MRPL47	PRAD	chr3	179320488	179320488	C	A	Nonsense_Mutation	p.E66*	8
MRPL47	UCEC	chr3	179311677	179311677	C	A	Missense_Mutation	p.D137Y	3
MRPL47	HNSC	chr3	179306692	179306692	G	C	Missense_Mutation	p.L241V	3
MRPL47	PAAD	chr3	179320442	179320442	G	T	Missense_Mutation	p.S81Y	3
MRPL47	PAAD	chr3	179316509	179316509	G	A	Missense_Mutation	p.A119V	3
MRPL47	UCEC	chr3	179306713	179306713	G	T	Missense_Mutation	p.L234I	2
MRPL47	UCEC	chr3	179310468	179310468	C	A	Missense_Mutation	p.R198L	2
MRPL47	STAD	chr3	179310501	179310501	G	A	Missense_Mutation	p.P187L	2
MRPL47	UCEC	chr3	179311580	179311580	C	A	Missense_Mutation	p.R169I	2
MRPL47	ESCA	chr3	179322325	179322325	C	A	Missense_Mutation		2
MRPL47	STAD	chr3	179306726	179306726	C	A	Missense_Mutation	p.K229N	2
MRPL47	LUAD	chr3	179316492	179316492	G	C	Missense_Mutation	p.P125A	2
MRPL47	STAD	chr3	179319544	179319544	T	G	Missense_Mutation	p.K93N	2
MRPL47	STAD	chr3	179311619	179311619	A	C	Missense_Mutation	p.L156R	2
MRPL47	ESCA	chr3	179320455	179320455	C	T	Missense_Mutation	p.E77K	2
MRPL47	LIHC	chr3	179310438	179310438	A	C	Missense_Mutation	p.F208C	2
MRPL47	PAAD	chr3	179316509	179316509	G	A	Missense_Mutation		2
MRPL47	HNSC	chr3	179310503	179310503	T	C	Missense_Mutation		1
MRPL47	SKCM	chr3	179322377	179322377	T	C	Silent	p.R12R	1
MRPL47	LIHC	chr3	179306739	179306739	T	-	Frame_Shift_Del	p.N225fs	1
MRPL47	COAD	chr3	179322408	179322408	G	T	Missense_Mutation	p.A2D	1
MRPL47	PAAD	chr3	179320442	179320442	G	T	Missense_Mutation		1
MRPL47	STAD	chr3	179306671	179306671	T	G	Missense_Mutation		1
MRPL47	LIHC	chr3	179306699	179306699	A	-	Frame_Shift_Del	p.F238fs	1
MRPL47	ESCA	chr3	179322325	179322325	C	A	Missense_Mutation	p.A30S	1
MRPL47	HNSC	chr3	179310503	179310503	T	C	Missense_Mutation	p.I186M	1
MRPL47	LUAD	chr3	179306784	179306784	C	T	Splice_Site		1
MRPL47	HNSC	chr3	179311660	179311660	T	C	Silent	p.L142L	1
MRPL47	BLCA	chr3	179306756	179306756	G	A	Silent		1
MRPL47	ESCA	chr3	179320455	179320455	C	T	Missense_Mutation		1
MRPL47	PRAD	chr3	179320488	179320488	C	A	Nonsense_Mutation	p.E66X	1
MRPL47	KIRC	chr3	179316503	179316503	C	T	Missense_Mutation	p.R121Q	1
MRPL47	BLCA	chr3	179306775	179306775	C	T	Missense_Mutation		1
MRPL47	LUAD	chr3	179322349	179322349	A	T	Missense_Mutation	p.S22T	1
MRPL47	ESCA	chr3	179316480	179316480	G	T	Missense_Mutation	p.P129T	1
MRPL47	PRAD	chr3	179320470	179320470	T	C	Missense_Mutation	p.K72E	1
MRPL47	LIHC	chr3	179306745	179306745	T	C	Missense_Mutation		1
MRPL47	BLCA	chr3	179322394	179322394	C	T	Missense_Mutation		1
MRPL47	LUAD	chr3	179311629	179311629	G	-	Frame_Shift_Del	p.L153fs	1
MRPL47	LIHC	chr3	179320533	179320533	G	T	Missense_Mutation		1
MRPL47	STAD	chr3	179306671	179306671	T	G	Missense_Mutation	p.S248R	1
MRPL47	BLCA	chr3	179306756	179306756	G	A	Silent	p.I219I	1
MRPL47	LUSC	chr3	179316559	179316559	C	A	Missense_Mutation	p.W102_splice	1
MRPL47	HNSC	chr3	179306761	179306761	G	T	Missense_Mutation		1
MRPL47	PRAD	chr3	179311582	179311582	C	A	Missense_Mutation	p.W168C	1
MRPL47	LIHC	chr3	179310438	179310438	A	C	Missense_Mutation		1
MRPL47	STAD	chr3	179311560	179311560	T	G	Missense_Mutation	p.I176L	1
MRPL47	BLCA	chr3	179306767	179306767	G	A	Nonsense_Mutation	p.R216*	1
MRPL47	LUSC	chr3	179311590	179311590	C	G	Missense_Mutation	p.G166R	1
MRPL47	HNSC	chr3	179311577	179311577	C	A	Missense_Mutation		1
MRPL47	READ	chr3	179306713	179306713	G	T	Missense_Mutation	p.L124I	1
MRPL47	LIHC	chr3	179311574	179311574	T	A	Missense_Mutation	p.D171V	1
MRPL47	THYM	chr3	179316468	179316510	CTAACCGCTCTGGACTTGGCATTGGCAATCTCTGCCGCTTGGC	-	Frame_Shift_Del	p.119_133del	1
MRPL47	BLCA	chr3	179322394	179322394	C	T	Missense_Mutation	p.A7T	1
MRPL47	LUSC	chr3	179320569	179320569	A	G	Silent	p.L39L	1
MRPL47	SKCM	chr3	179316479	179316479	G	A	Missense_Mutation	p.P19L	1
MRPL47	HNSC	chr3	179311660	179311660	T	C	Silent		1
MRPL47	THYM	chr3	179320556	179320556	G	T	Missense_Mutation	p.T43K	1
MRPL47	COAD	chr3	179306775	179306775	C	T	Missense_Mutation	p.R103H	1
MRPL47	MESO	chr3	179320472	179320472	G	A	Missense_Mutation	p.P71L	1
MRPL47	HNSC	chr3	179306692	179306692	G	C	Missense_Mutation		1
MRPL47	SKCM	chr3	179316479	179316479	G	A	Missense_Mutation	p.P129L	1
MRPL47	LIHC	chr3	179310506	179310506	A	-	Frame_Shift_Del	p.V185fs	1
MRPL47	THYM	chr3	179316468	179316510	CTAACCGCTCTGGACTTGGCATTGGCAATCTCTGCCGCTTGGC	-	Frame_Shift_Del	p.AKRQRLPMPSPERLD119fs	1
MRPL47	COAD	chr3	179316461	179316471	ATCCTTACCTT	-	Frame_Shift_Del	p.24_24del	1

Copy number variation (CNV) of MRPL47
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MRPL47
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
58185	BRCA	TCGA-A2-A3Y0	ACTL6A	chr3	179280905	+	MRPL47	chr3	179311683	-
99011	N/A	BI861221	MRPL47	chr3	179306574	-	ELF1	chr13	41285248	+
58187	STAD	TCGA-FP-8211-01A	NDUFB5	chr3	179322727	+	MRPL47	chr3	179306783	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
HNSC	MRPL47	0.000508144029643378	0.014
MESO	MRPL47	0.0321984765337079	0.87
LIHC	MRPL47	0.0348365868364451	0.91

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	MRPL47	0.0391548775379009	1
LUAD	MRPL47	0.0273515565972852	0.79
LGG	MRPL47	0.0124018773457891	0.38
UCEC	MRPL47	0.00435009702759686	0.14
ESCA	MRPL47	0.000782139402830801	0.026
THYM	MRPL47	0.0236453723165306	0.71

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source