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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: PURA (NCBI Gene ID:5813)

Gene Summary

Gene Summary

Gene Information	Gene Name: PURA
	Gene ID: 5813
	Gene Symbol	PURA
	Gene ID	5813
	Gene Name	purine rich element binding protein A
	Synonyms	MRD31\|PUR-ALPHA\|PUR1\|PURALPHA
	Cytomap	5q31.3
	Type of Gene	protein-coding
	Description	transcriptional activator protein Pur-alphapurine-rich single-stranded DNA-binding protein alpha
	Modification date	20200313
	UniProtAcc	Q00577

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PURA	GO:0006268	DNA unwinding involved in DNA replication	15777841

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
PURA	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'PURA[title] AND translation [title] AND human.'

Gene	Title	PMID
PURA	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
ESCA	PURA	-1.33299608395937	0.0009765625
KICH	PURA	-1.14059232372443	0.0159729719161987
LIHC	PURA	1.34399548884957	0.0407076861351475
THCA	PURA	-1.33240407255107	2.91518004362401e-07
KIRP	PURA	-2.82755926877162	9.90275293588639e-06

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
CESC	PURA	1	2	0.0456619534450197	0.160828395061728	0.296649149659864	0.244046401353317	0.530041299312877
UVM	PURA	1	2	0.0351873900548434	0.133236165577342	0.280336293007769	0.615616771724065	0.885200489404713

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with PURA (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
KICH	Cell metabolism gene	PURA	PRKAA1	0.804757449	7.23E-22
KICH	Epifactor	PURA	PRKAA1	0.804757449	7.23E-22
KICH	IUPHAR	PURA	PRKAA1	0.804757449	7.23E-22
KICH	Kinase	PURA	PRKAA1	0.804757449	7.23E-22
KICH	TSG	PURA	PRKAA1	0.804757449	7.23E-22
PAAD	CGC	PURA	APC	0.827289706	3.35E-47
PAAD	TSG	PURA	APC	0.827289706	3.35E-47
THYM	Cell metabolism gene	PURA	SYNJ1	0.801707857	1.36E-28
THYM	Cell metabolism gene	PURA	PIGK	0.80186719	1.31E-28
THYM	Cell metabolism gene	PURA	MED23	0.80282897	1.01E-28
THYM	Cell metabolism gene	PURA	DBT	0.803212437	9.06E-29
THYM	Cell metabolism gene	PURA	RANBP2	0.803868412	7.58E-29
THYM	Cell metabolism gene	PURA	COL4A3BP	0.805290767	5.12E-29
THYM	Cell metabolism gene	PURA	SEC31A	0.81274727	6.25E-30
THYM	Cell metabolism gene	PURA	PRKAR1A	0.828797602	4.81E-32
THYM	Cell metabolism gene	PURA	PIK3R4	0.829721292	3.58E-32
THYM	Cell metabolism gene	PURA	GXYLT1	0.839861615	1.24E-33
THYM	Cell metabolism gene	PURA	TNPO1	0.850395001	2.90E-35
THYM	Cell metabolism gene	PURA	LONP2	0.851158413	2.19E-35
THYM	Cell metabolism gene	PURA	PIK3C2A	0.873855382	2.16E-39
THYM	CGC	PURA	RANBP2	0.803868412	7.58E-29
THYM	CGC	PURA	DICER1	0.810931633	1.05E-29
THYM	CGC	PURA	ARHGEF12	0.814489947	3.77E-30
THYM	CGC	PURA	ATRX	0.823128464	2.84E-31
THYM	CGC	PURA	PRKAR1A	0.828797602	4.81E-32
THYM	CGC	PURA	FBXO11	0.831817971	1.82E-32
THYM	CGC	PURA	ARHGAP5	0.861937209	3.37E-37
THYM	CGC	PURA	AFF4	0.878767995	2.32E-40
THYM	Epifactor	PURA	DZIP3	0.802370345	1.14E-28
THYM	Epifactor	PURA	ZMYND11	0.807620577	2.68E-29
THYM	Epifactor	PURA	ATRX	0.823128464	2.84E-31
THYM	Epifactor	PURA	HCFC2	0.824102887	2.10E-31
THYM	Epifactor	PURA	KDM3B	0.846979624	1.01E-34
THYM	IUPHAR	PURA	SYNJ1	0.801707857	1.36E-28
THYM	IUPHAR	PURA	XIAP	0.802844259	1.00E-28
THYM	IUPHAR	PURA	ATP7A	0.804994805	5.56E-29
THYM	IUPHAR	PURA	SLC9A6	0.806364663	3.81E-29
THYM	IUPHAR	PURA	TNKS	0.806795893	3.38E-29
THYM	IUPHAR	PURA	ZMYND11	0.807620577	2.68E-29
THYM	IUPHAR	PURA	SLC35A5	0.812154464	7.41E-30
THYM	IUPHAR	PURA	MAGT1	0.815447029	2.85E-30
THYM	IUPHAR	PURA	NEK4	0.816185744	2.29E-30
THYM	IUPHAR	PURA	SLC25A36	0.816547176	2.06E-30
THYM	IUPHAR	PURA	TRPM7	0.817766607	1.44E-30
THYM	IUPHAR	PURA	PDPK1	0.827707532	6.80E-32
THYM	IUPHAR	PURA	PRKAR1A	0.828797602	4.81E-32
THYM	IUPHAR	PURA	PIK3R4	0.829721292	3.58E-32
THYM	IUPHAR	PURA	FBXO11	0.831817971	1.82E-32
THYM	IUPHAR	PURA	PKN2	0.837353768	2.91E-33
THYM	IUPHAR	PURA	PREPL	0.845769246	1.56E-34
THYM	IUPHAR	PURA	KDM3B	0.846979624	1.01E-34
THYM	IUPHAR	PURA	SLC26A2	0.84951373	4.02E-35
THYM	IUPHAR	PURA	SLC35F5	0.860429312	6.17E-37
THYM	IUPHAR	PURA	PIK3C2A	0.873855382	2.16E-39
THYM	IUPHAR	PURA	MAP4K3	0.885461056	9.45E-42
THYM	Kinase	PURA	COL4A3BP	0.805290767	5.12E-29
THYM	Kinase	PURA	NEK4	0.816185744	2.29E-30
THYM	Kinase	PURA	TRPM7	0.817766607	1.44E-30
THYM	Kinase	PURA	PDPK1	0.827707532	6.80E-32
THYM	Kinase	PURA	PIK3R4	0.829721292	3.58E-32
THYM	Kinase	PURA	PKN2	0.837353768	2.91E-33
THYM	Kinase	PURA	MAP4K3	0.885461056	9.45E-42
THYM	TF	PURA	ZNF594	0.80019053	2.05E-28
THYM	TF	PURA	TMF1	0.802817924	1.01E-28
THYM	TF	PURA	ZNF268	0.803269333	8.92E-29
THYM	TF	PURA	ZNF223	0.804461801	6.44E-29
THYM	TF	PURA	ZNF420	0.811073868	1.01E-29
THYM	TF	PURA	ZNF304	0.811194683	9.76E-30
THYM	TF	PURA	RBAK	0.811261398	9.57E-30
THYM	TF	PURA	ZNF615	0.811330707	9.38E-30
THYM	TF	PURA	ZNF471	0.811486107	8.98E-30
THYM	TF	PURA	ZNF354B	0.811595406	8.70E-30
THYM	TF	PURA	ZXDB	0.812762279	6.22E-30
THYM	TF	PURA	ZNF461	0.813561171	4.94E-30
THYM	TF	PURA	ZNF780B	0.815001744	3.24E-30
THYM	TF	PURA	NFAT5	0.816778936	1.92E-30
THYM	TF	PURA	ZBTB43	0.825803603	1.24E-31
THYM	TF	PURA	ZNF614	0.828579569	5.15E-32
THYM	TF	PURA	ZNF585B	0.831267139	2.17E-32
THYM	TF	PURA	ZNF91	0.833168585	1.17E-32
THYM	TF	PURA	ZNF432	0.835622167	5.19E-33
THYM	TF	PURA	MEF2A	0.837768579	2.53E-33
THYM	TF	PURA	SMAD5	0.842939102	4.26E-34
THYM	TF	PURA	ZNF12	0.846215806	1.33E-34
THYM	TF	PURA	ZNF441	0.846499782	1.20E-34
THYM	TF	PURA	BBX	0.881353809	6.90E-41
THYM	TSG	PURA	ZMYND11	0.807620577	2.68E-29
THYM	TSG	PURA	DICER1	0.810931633	1.05E-29
THYM	TSG	PURA	KRIT1	0.811960954	7.83E-30
THYM	TSG	PURA	ARHGEF12	0.814489947	3.77E-30
THYM	TSG	PURA	DLG1	0.820900211	5.60E-31
THYM	TSG	PURA	PHLPP2	0.827951931	6.29E-32
THYM	TSG	PURA	PRKAR1A	0.828797602	4.81E-32
THYM	TSG	PURA	DNAJB4	0.831889999	1.78E-32
THYM	TSG	PURA	NUMB	0.839656026	1.33E-33
THYM	TSG	PURA	KDM3B	0.846979624	1.01E-34
UCS	Cell metabolism gene	PURA	SYNJ1	0.801707857	1.36E-28
UCS	Cell metabolism gene	PURA	PIGK	0.80186719	1.31E-28
UCS	Cell metabolism gene	PURA	MED23	0.80282897	1.01E-28
UCS	Cell metabolism gene	PURA	DBT	0.803212437	9.06E-29
UCS	Cell metabolism gene	PURA	RANBP2	0.803868412	7.58E-29
UCS	Cell metabolism gene	PURA	COL4A3BP	0.805290767	5.12E-29
UCS	Cell metabolism gene	PURA	SEC31A	0.81274727	6.25E-30
UCS	Cell metabolism gene	PURA	PRKAR1A	0.828797602	4.81E-32
UCS	Cell metabolism gene	PURA	PIK3R4	0.829721292	3.58E-32
UCS	Cell metabolism gene	PURA	GXYLT1	0.839861615	1.24E-33
UCS	Cell metabolism gene	PURA	TNPO1	0.850395001	2.90E-35
UCS	Cell metabolism gene	PURA	LONP2	0.851158413	2.19E-35
UCS	Cell metabolism gene	PURA	PIK3C2A	0.873855382	2.16E-39
UCS	CGC	PURA	RANBP2	0.803868412	7.58E-29
UCS	CGC	PURA	DICER1	0.810931633	1.05E-29
UCS	CGC	PURA	ARHGEF12	0.814489947	3.77E-30
UCS	CGC	PURA	ATRX	0.823128464	2.84E-31
UCS	CGC	PURA	PRKAR1A	0.828797602	4.81E-32
UCS	CGC	PURA	FBXO11	0.831817971	1.82E-32
UCS	CGC	PURA	ARHGAP5	0.861937209	3.37E-37
UCS	CGC	PURA	AFF4	0.878767995	2.32E-40
UCS	Epifactor	PURA	DZIP3	0.802370345	1.14E-28
UCS	Epifactor	PURA	ZMYND11	0.807620577	2.68E-29
UCS	Epifactor	PURA	ATRX	0.823128464	2.84E-31
UCS	Epifactor	PURA	HCFC2	0.824102887	2.10E-31
UCS	Epifactor	PURA	KDM3B	0.846979624	1.01E-34
UCS	IUPHAR	PURA	SYNJ1	0.801707857	1.36E-28
UCS	IUPHAR	PURA	XIAP	0.802844259	1.00E-28
UCS	IUPHAR	PURA	ATP7A	0.804994805	5.56E-29
UCS	IUPHAR	PURA	SLC9A6	0.806364663	3.81E-29
UCS	IUPHAR	PURA	TNKS	0.806795893	3.38E-29
UCS	IUPHAR	PURA	ZMYND11	0.807620577	2.68E-29
UCS	IUPHAR	PURA	SLC35A5	0.812154464	7.41E-30
UCS	IUPHAR	PURA	MAGT1	0.815447029	2.85E-30
UCS	IUPHAR	PURA	NEK4	0.816185744	2.29E-30
UCS	IUPHAR	PURA	SLC25A36	0.816547176	2.06E-30
UCS	IUPHAR	PURA	TRPM7	0.817766607	1.44E-30
UCS	IUPHAR	PURA	PDPK1	0.827707532	6.80E-32
UCS	IUPHAR	PURA	PRKAR1A	0.828797602	4.81E-32
UCS	IUPHAR	PURA	PIK3R4	0.829721292	3.58E-32
UCS	IUPHAR	PURA	FBXO11	0.831817971	1.82E-32
UCS	IUPHAR	PURA	PKN2	0.837353768	2.91E-33
UCS	IUPHAR	PURA	PREPL	0.845769246	1.56E-34
UCS	IUPHAR	PURA	KDM3B	0.846979624	1.01E-34
UCS	IUPHAR	PURA	SLC26A2	0.84951373	4.02E-35
UCS	IUPHAR	PURA	SLC35F5	0.860429312	6.17E-37
UCS	IUPHAR	PURA	PIK3C2A	0.873855382	2.16E-39
UCS	IUPHAR	PURA	MAP4K3	0.885461056	9.45E-42
UCS	Kinase	PURA	COL4A3BP	0.805290767	5.12E-29
UCS	Kinase	PURA	NEK4	0.816185744	2.29E-30
UCS	Kinase	PURA	TRPM7	0.817766607	1.44E-30
UCS	Kinase	PURA	PDPK1	0.827707532	6.80E-32
UCS	Kinase	PURA	PIK3R4	0.829721292	3.58E-32
UCS	Kinase	PURA	PKN2	0.837353768	2.91E-33
UCS	Kinase	PURA	MAP4K3	0.885461056	9.45E-42
UCS	TF	PURA	ZNF594	0.80019053	2.05E-28
UCS	TF	PURA	TMF1	0.802817924	1.01E-28
UCS	TF	PURA	ZNF268	0.803269333	8.92E-29
UCS	TF	PURA	ZNF223	0.804461801	6.44E-29
UCS	TF	PURA	ZNF420	0.811073868	1.01E-29
UCS	TF	PURA	ZNF304	0.811194683	9.76E-30
UCS	TF	PURA	RBAK	0.811261398	9.57E-30
UCS	TF	PURA	ZNF615	0.811330707	9.38E-30
UCS	TF	PURA	ZNF471	0.811486107	8.98E-30
UCS	TF	PURA	ZNF354B	0.811595406	8.70E-30
UCS	TF	PURA	ZXDB	0.812762279	6.22E-30
UCS	TF	PURA	ZNF461	0.813561171	4.94E-30
UCS	TF	PURA	ZNF780B	0.815001744	3.24E-30
UCS	TF	PURA	NFAT5	0.816778936	1.92E-30
UCS	TF	PURA	ZBTB43	0.825803603	1.24E-31
UCS	TF	PURA	ZNF614	0.828579569	5.15E-32
UCS	TF	PURA	ZNF585B	0.831267139	2.17E-32
UCS	TF	PURA	ZNF91	0.833168585	1.17E-32
UCS	TF	PURA	ZNF432	0.835622167	5.19E-33
UCS	TF	PURA	MEF2A	0.837768579	2.53E-33
UCS	TF	PURA	SMAD5	0.842939102	4.26E-34
UCS	TF	PURA	ZNF12	0.846215806	1.33E-34
UCS	TF	PURA	ZNF441	0.846499782	1.20E-34
UCS	TF	PURA	BBX	0.881353809	6.90E-41
UCS	TSG	PURA	ZMYND11	0.807620577	2.68E-29
UCS	TSG	PURA	DICER1	0.810931633	1.05E-29
UCS	TSG	PURA	KRIT1	0.811960954	7.83E-30
UCS	TSG	PURA	ARHGEF12	0.814489947	3.77E-30
UCS	TSG	PURA	DLG1	0.820900211	5.60E-31
UCS	TSG	PURA	PHLPP2	0.827951931	6.29E-32
UCS	TSG	PURA	PRKAR1A	0.828797602	4.81E-32
UCS	TSG	PURA	DNAJB4	0.831889999	1.78E-32
UCS	TSG	PURA	NUMB	0.839656026	1.33E-33
UCS	TSG	PURA	KDM3B	0.846979624	1.01E-34
UVM	Cell metabolism gene	PURA	IPMK	0.801547131	4.23E-19
UVM	Cell metabolism gene	PURA	SUCLA2	0.803268755	3.12E-19
UVM	Cell metabolism gene	PURA	UGP2	0.804521418	2.49E-19
UVM	Cell metabolism gene	PURA	PANK3	0.805377707	2.14E-19
UVM	Cell metabolism gene	PURA	LPGAT1	0.805637592	2.04E-19
UVM	Cell metabolism gene	PURA	BPNT1	0.806770707	1.66E-19
UVM	Cell metabolism gene	PURA	MINPP1	0.809106049	1.09E-19
UVM	Cell metabolism gene	PURA	NUPL2	0.809197067	1.07E-19
UVM	Cell metabolism gene	PURA	ACADSB	0.810080386	9.07E-20
UVM	Cell metabolism gene	PURA	ALG13	0.810483767	8.42E-20
UVM	Cell metabolism gene	PURA	DCK	0.810573902	8.28E-20
UVM	Cell metabolism gene	PURA	NUP107	0.815614383	3.20E-20
UVM	Cell metabolism gene	PURA	PPAT	0.817497295	2.23E-20
UVM	Cell metabolism gene	PURA	GNPDA2	0.818231131	1.93E-20
UVM	Cell metabolism gene	PURA	NUP50	0.818718321	1.76E-20
UVM	Cell metabolism gene	PURA	UGCG	0.822036733	9.15E-21
UVM	Cell metabolism gene	PURA	ACSL4	0.822383549	8.54E-21
UVM	Cell metabolism gene	PURA	ALG10B	0.822495064	8.36E-21
UVM	Cell metabolism gene	PURA	UGGT2	0.822909973	7.69E-21
UVM	Cell metabolism gene	PURA	DBT	0.82338367	7.00E-21
UVM	Cell metabolism gene	PURA	HIF1A	0.824975788	5.07E-21
UVM	Cell metabolism gene	PURA	IDI1	0.827084581	3.30E-21
UVM	Cell metabolism gene	PURA	AASDHPPT	0.827896539	2.79E-21
UVM	Cell metabolism gene	PURA	PIP5K1A	0.82881602	2.31E-21
UVM	Cell metabolism gene	PURA	NAMPT	0.830493106	1.63E-21
UVM	Cell metabolism gene	PURA	CDK8	0.83093954	1.48E-21
UVM	Cell metabolism gene	PURA	DIS3	0.832344364	1.10E-21
UVM	Cell metabolism gene	PURA	GRPEL2	0.832810092	9.96E-22
UVM	Cell metabolism gene	PURA	FAR1	0.833378268	8.82E-22
UVM	Cell metabolism gene	PURA	SEC24B	0.83447662	6.97E-22
UVM	Cell metabolism gene	PURA	NUDT12	0.834967355	6.27E-22
UVM	Cell metabolism gene	PURA	PIK3CA	0.83505233	6.16E-22
UVM	Cell metabolism gene	PURA	HMGCS1	0.835439578	5.66E-22
UVM	Cell metabolism gene	PURA	ETNK1	0.835627119	5.43E-22
UVM	Cell metabolism gene	PURA	PIK3C3	0.835839538	5.19E-22
UVM	Cell metabolism gene	PURA	AGPS	0.836997048	4.03E-22
UVM	Cell metabolism gene	PURA	SACM1L	0.837526989	3.59E-22
UVM	Cell metabolism gene	PURA	MANEA	0.837909294	3.30E-22
UVM	Cell metabolism gene	PURA	GLS	0.838021033	3.22E-22
UVM	Cell metabolism gene	PURA	CSGALNACT2	0.841656176	1.43E-22
UVM	Cell metabolism gene	PURA	SPTLC1	0.842274718	1.24E-22
UVM	Cell metabolism gene	PURA	ARFGEF2	0.848161429	3.17E-23
UVM	Cell metabolism gene	PURA	EDEM3	0.848203014	3.14E-23
UVM	Cell metabolism gene	PURA	PNPLA8	0.852758728	1.05E-23
UVM	Cell metabolism gene	PURA	FBXL3	0.854114539	7.50E-24
UVM	Cell metabolism gene	PURA	MTMR6	0.854553013	6.72E-24
UVM	Cell metabolism gene	PURA	CLOCK	0.854966489	6.07E-24
UVM	Cell metabolism gene	PURA	TXNRD1	0.855635645	5.13E-24
UVM	Cell metabolism gene	PURA	PSMC6	0.857715802	3.04E-24
UVM	Cell metabolism gene	PURA	GPD2	0.859764786	1.80E-24
UVM	Cell metabolism gene	PURA	RANBP2	0.860436805	1.51E-24
UVM	Cell metabolism gene	PURA	MTR	0.862959649	7.79E-25
UVM	Cell metabolism gene	PURA	TNPO1	0.864167775	5.65E-25
UVM	Cell metabolism gene	PURA	PIK3R1	0.866419747	3.08E-25
UVM	Cell metabolism gene	PURA	XPO1	0.866729588	2.83E-25
UVM	Cell metabolism gene	PURA	PHAX	0.868762543	1.62E-25
UVM	Cell metabolism gene	PURA	NUPL1	0.872331841	5.92E-26
UVM	Cell metabolism gene	PURA	SMG1	0.873901373	3.77E-26
UVM	Cell metabolism gene	PURA	MED17	0.874208749	3.45E-26
UVM	Cell metabolism gene	PURA	COL4A3BP	0.875957413	2.07E-26
UVM	Cell metabolism gene	PURA	CNOT8	0.877626023	1.26E-26
UVM	Cell metabolism gene	PURA	PRKAA1	0.888542069	4.08E-28
UVM	Cell metabolism gene	PURA	PIKFYVE	0.914519587	2.16E-32
UVM	CGC	PURA	POT1	0.803910554	2.78E-19
UVM	CGC	PURA	JAK2	0.804061679	2.71E-19
UVM	CGC	PURA	STRN	0.805493211	2.10E-19
UVM	CGC	PURA	PALB2	0.806183473	1.85E-19
UVM	CGC	PURA	MSH2	0.807409844	1.48E-19
UVM	CGC	PURA	MAP3K1	0.807689606	1.41E-19
UVM	CGC	PURA	HSP90AA1	0.808172772	1.29E-19
UVM	CGC	PURA	ZMYM2	0.810123359	9.00E-20
UVM	CGC	PURA	RB1	0.812591136	5.68E-20
UVM	CGC	PURA	ARHGAP5	0.814848496	3.71E-20
UVM	CGC	PURA	KTN1	0.817198757	2.36E-20
UVM	CGC	PURA	KDM5A	0.823630503	6.66E-21
UVM	CGC	PURA	ITGAV	0.824209827	5.92E-21
UVM	CGC	PURA	HIF1A	0.824975788	5.07E-21
UVM	CGC	PURA	BCLAF1	0.825319055	4.73E-21
UVM	CGC	PURA	CDKN1B	0.825527238	4.54E-21
UVM	CGC	PURA	GOPC	0.826796035	3.50E-21
UVM	CGC	PURA	KIF5B	0.827340635	3.13E-21
UVM	CGC	PURA	ERCC4	0.827655959	2.93E-21
UVM	CGC	PURA	MALT1	0.829185103	2.14E-21
UVM	CGC	PURA	KRAS	0.829620414	1.95E-21
UVM	CGC	PURA	STAG2	0.829836477	1.87E-21
UVM	CGC	PURA	PWWP2A	0.830976706	1.47E-21
UVM	CGC	PURA	APC	0.83364088	8.34E-22
UVM	CGC	PURA	BIRC6	0.833820052	8.03E-22
UVM	CGC	PURA	RAD17	0.833928133	7.84E-22
UVM	CGC	PURA	BMPR1A	0.834637011	6.73E-22
UVM	CGC	PURA	PIK3CA	0.83505233	6.16E-22
UVM	CGC	PURA	PMS1	0.835137199	6.04E-22
UVM	CGC	PURA	ETNK1	0.835627119	5.43E-22
UVM	CGC	PURA	MLLT10	0.835721451	5.32E-22
UVM	CGC	PURA	ATM	0.836753395	4.25E-22
UVM	CGC	PURA	CUL3	0.841887119	1.36E-22
UVM	CGC	PURA	N4BP2	0.842687	1.13E-22
UVM	CGC	PURA	IL6ST	0.844156077	8.07E-23
UVM	CGC	PURA	USP8	0.845735094	5.60E-23
UVM	CGC	PURA	CREB1	0.847930883	3.34E-23
UVM	CGC	PURA	ARID2	0.851071446	1.58E-23
UVM	CGC	PURA	ABI1	0.851774041	1.33E-23
UVM	CGC	PURA	SMAD4	0.854628769	6.60E-24
UVM	CGC	PURA	RGPD3	0.856074717	4.60E-24
UVM	CGC	PURA	DICER1	0.856646957	3.98E-24
UVM	CGC	PURA	ATF1	0.860416391	1.52E-24
UVM	CGC	PURA	RANBP2	0.860436805	1.51E-24
UVM	CGC	PURA	FBXO11	0.8637836	6.26E-25
UVM	CGC	PURA	PIK3R1	0.866419747	3.08E-25
UVM	CGC	PURA	XPO1	0.866729588	2.83E-25
UVM	CGC	PURA	CDC73	0.87040468	1.02E-25
UVM	CGC	PURA	AFF4	0.877082944	1.48E-26
UVM	CGC	PURA	SF3B1	0.877277574	1.40E-26
UVM	CGC	PURA	SUZ12	0.892698923	1.00E-28
UVM	CGC	PURA	DDX5	0.903850127	1.73E-30
UVM	Epifactor	PURA	CTBP2	0.800397656	5.18E-19
UVM	Epifactor	PURA	BRWD1	0.801695576	4.12E-19
UVM	Epifactor	PURA	USP12	0.803870826	2.80E-19
UVM	Epifactor	PURA	JAK2	0.804061679	2.71E-19
UVM	Epifactor	PURA	INO80D	0.805046533	2.27E-19
UVM	Epifactor	PURA	RLIM	0.809243921	1.06E-19
UVM	Epifactor	PURA	MYSM1	0.809499886	1.01E-19
UVM	Epifactor	PURA	SUDS3	0.810025027	9.16E-20
UVM	Epifactor	PURA	ZMYM2	0.810123359	9.00E-20
UVM	Epifactor	PURA	SENP1	0.810313043	8.69E-20
UVM	Epifactor	PURA	ATAD2B	0.811784771	6.61E-20
UVM	Epifactor	PURA	RB1	0.812591136	5.68E-20
UVM	Epifactor	PURA	BRMS1L	0.814238158	4.16E-20
UVM	Epifactor	PURA	SHPRH	0.815849995	3.06E-20
UVM	Epifactor	PURA	BRD8	0.81634353	2.79E-20
UVM	Epifactor	PURA	HCFC2	0.817192334	2.37E-20
UVM	Epifactor	PURA	BAZ2B	0.817570839	2.20E-20
UVM	Epifactor	PURA	PCGF6	0.819642866	1.47E-20
UVM	Epifactor	PURA	HAT1	0.821027746	1.12E-20
UVM	Epifactor	PURA	TDG	0.821649468	9.89E-21
UVM	Epifactor	PURA	ACTR6	0.823282156	7.14E-21
UVM	Epifactor	PURA	TAF1	0.823413106	6.95E-21
UVM	Epifactor	PURA	KDM5A	0.823630503	6.66E-21
UVM	Epifactor	PURA	RMI1	0.823816431	6.41E-21
UVM	Epifactor	PURA	UBR2	0.824455741	5.64E-21
UVM	Epifactor	PURA	PHIP	0.825810273	4.28E-21
UVM	Epifactor	PURA	MPHOSPH8	0.826147545	4.00E-21
UVM	Epifactor	PURA	TADA1	0.829525094	1.99E-21
UVM	Epifactor	PURA	ZRANB3	0.830113937	1.76E-21
UVM	Epifactor	PURA	NSL1	0.832195882	1.14E-21
UVM	Epifactor	PURA	FAM175B	0.834408716	7.07E-22
UVM	Epifactor	PURA	MLLT10	0.835721451	5.32E-22
UVM	Epifactor	PURA	SIRT1	0.836717489	4.28E-22
UVM	Epifactor	PURA	ATM	0.836753395	4.25E-22
UVM	Epifactor	PURA	UHRF2	0.83843361	2.94E-22
UVM	Epifactor	PURA	YEATS4	0.840098244	2.03E-22
UVM	Epifactor	PURA	JMJD1C	0.84160848	1.44E-22
UVM	Epifactor	PURA	CUL3	0.841887119	1.36E-22
UVM	Epifactor	PURA	OGT	0.84229933	1.23E-22
UVM	Epifactor	PURA	USP15	0.842941246	1.07E-22
UVM	Epifactor	PURA	ZMYND11	0.843978135	8.41E-23
UVM	Epifactor	PURA	TLK1	0.844180264	8.03E-23
UVM	Epifactor	PURA	BRCC3	0.845228508	6.30E-23
UVM	Epifactor	PURA	PARG	0.846334905	4.87E-23
UVM	Epifactor	PURA	ARID4A	0.846855987	4.31E-23
UVM	Epifactor	PURA	CDK17	0.847803374	3.45E-23
UVM	Epifactor	PURA	WAC	0.847809626	3.44E-23
UVM	Epifactor	PURA	UCHL5	0.848855501	2.69E-23
UVM	Epifactor	PURA	NIPBL	0.850553027	1.79E-23
UVM	Epifactor	PURA	CUL5	0.850586883	1.77E-23
UVM	Epifactor	PURA	ARID2	0.851071446	1.58E-23
UVM	Epifactor	PURA	SMEK1	0.852139284	1.22E-23
UVM	Epifactor	PURA	CLOCK	0.854966489	6.07E-24
UVM	Epifactor	PURA	CHD1	0.85663845	3.99E-24
UVM	Epifactor	PURA	RCOR3	0.857765498	3.00E-24
UVM	Epifactor	PURA	AEBP2	0.861637346	1.10E-24
UVM	Epifactor	PURA	SMEK2	0.863671504	6.45E-25
UVM	Epifactor	PURA	EPC1	0.867036478	2.60E-25
UVM	Epifactor	PURA	ATF2	0.868723133	1.63E-25
UVM	Epifactor	PURA	CDC73	0.87040468	1.02E-25
UVM	Epifactor	PURA	YY1	0.871263926	8.02E-26
UVM	Epifactor	PURA	CUL2	0.876838903	1.59E-26
UVM	Epifactor	PURA	SF3B1	0.877277574	1.40E-26
UVM	Epifactor	PURA	EPC2	0.880805429	4.80E-27
UVM	Epifactor	PURA	TAF7	0.888143253	4.65E-28
UVM	Epifactor	PURA	CHD9	0.888192162	4.58E-28
UVM	Epifactor	PURA	PRKAA1	0.888542069	4.08E-28
UVM	Epifactor	PURA	SUZ12	0.892698923	1.00E-28
UVM	IUPHAR	PURA	BRWD1	0.801695576	4.12E-19
UVM	IUPHAR	PURA	SLC38A2	0.802301658	3.70E-19
UVM	IUPHAR	PURA	JAK2	0.804061679	2.71E-19
UVM	IUPHAR	PURA	DPP8	0.804169125	2.66E-19
UVM	IUPHAR	PURA	MAPK9	0.805000065	2.29E-19
UVM	IUPHAR	PURA	IRAK4	0.8068455	1.64E-19
UVM	IUPHAR	PURA	SLC30A9	0.807336387	1.50E-19
UVM	IUPHAR	PURA	ATP6V0A2	0.807358127	1.49E-19
UVM	IUPHAR	PURA	MAP3K1	0.807689606	1.41E-19
UVM	IUPHAR	PURA	HSP90AA1	0.808172772	1.29E-19
UVM	IUPHAR	PURA	MAP4K3	0.808224855	1.28E-19
UVM	IUPHAR	PURA	SENP1	0.810313043	8.69E-20
UVM	IUPHAR	PURA	SLC25A40	0.810702746	8.08E-20
UVM	IUPHAR	PURA	ATAD2B	0.811784771	6.61E-20
UVM	IUPHAR	PURA	PRMT3	0.812316221	5.98E-20
UVM	IUPHAR	PURA	ABCA5	0.81398268	4.37E-20
UVM	IUPHAR	PURA	TBK1	0.816127947	2.90E-20
UVM	IUPHAR	PURA	BRD8	0.81634353	2.79E-20
UVM	IUPHAR	PURA	PPAT	0.817497295	2.23E-20
UVM	IUPHAR	PURA	BAZ2B	0.817570839	2.20E-20
UVM	IUPHAR	PURA	TTBK2	0.820306623	1.29E-20
UVM	IUPHAR	PURA	HAT1	0.821027746	1.12E-20
UVM	IUPHAR	PURA	MAGT1	0.821514577	1.02E-20
UVM	IUPHAR	PURA	VRK2	0.821968377	9.28E-21
UVM	IUPHAR	PURA	UGCG	0.822036733	9.15E-21
UVM	IUPHAR	PURA	MAPK6	0.822384462	8.54E-21
UVM	IUPHAR	PURA	SLC25A24	0.823155549	7.32E-21
UVM	IUPHAR	PURA	TAF1	0.823413106	6.95E-21
UVM	IUPHAR	PURA	KDM5A	0.823630503	6.66E-21
UVM	IUPHAR	PURA	ITGAV	0.824209827	5.92E-21
UVM	IUPHAR	PURA	PHIP	0.825810273	4.28E-21
UVM	IUPHAR	PURA	IDI1	0.827084581	3.30E-21
UVM	IUPHAR	PURA	SLC2A13	0.82758923	2.98E-21
UVM	IUPHAR	PURA	PKN2	0.827902333	2.79E-21
UVM	IUPHAR	PURA	ADAM17	0.828461967	2.48E-21
UVM	IUPHAR	PURA	PIP5K1A	0.82881602	2.31E-21
UVM	IUPHAR	PURA	MALT1	0.829185103	2.14E-21
UVM	IUPHAR	PURA	KRAS	0.829620414	1.95E-21
UVM	IUPHAR	PURA	PRPF4B	0.830590647	1.59E-21
UVM	IUPHAR	PURA	CDK8	0.83093954	1.48E-21
UVM	IUPHAR	PURA	BIRC6	0.833820052	8.03E-22
UVM	IUPHAR	PURA	RIOK3	0.833926781	7.85E-22
UVM	IUPHAR	PURA	BMPR1A	0.834637011	6.73E-22
UVM	IUPHAR	PURA	PIK3CA	0.83505233	6.16E-22
UVM	IUPHAR	PURA	LNPEP	0.835058219	6.15E-22
UVM	IUPHAR	PURA	HMGCS1	0.835439578	5.66E-22
UVM	IUPHAR	PURA	PIK3C3	0.835839538	5.19E-22
UVM	IUPHAR	PURA	BIRC2	0.836319132	4.67E-22
UVM	IUPHAR	PURA	SIRT1	0.836717489	4.28E-22
UVM	IUPHAR	PURA	ATM	0.836753395	4.25E-22
UVM	IUPHAR	PURA	SLC25A46	0.836899874	4.12E-22
UVM	IUPHAR	PURA	GLS	0.838021033	3.22E-22
UVM	IUPHAR	PURA	DYRK1A	0.840333258	1.92E-22
UVM	IUPHAR	PURA	JMJD1C	0.84160848	1.44E-22
UVM	IUPHAR	PURA	SPTLC1	0.842274718	1.24E-22
UVM	IUPHAR	PURA	ZMYND11	0.843978135	8.41E-23
UVM	IUPHAR	PURA	IL6ST	0.844156077	8.07E-23
UVM	IUPHAR	PURA	TLK1	0.844180264	8.03E-23
UVM	IUPHAR	PURA	MAPK8	0.845465455	5.96E-23
UVM	IUPHAR	PURA	NEK7	0.847098299	4.07E-23
UVM	IUPHAR	PURA	CDK17	0.847803374	3.45E-23
UVM	IUPHAR	PURA	SLK	0.848722096	2.77E-23
UVM	IUPHAR	PURA	CSNK1A1	0.849127305	2.52E-23
UVM	IUPHAR	PURA	TRPM7	0.850335786	1.88E-23
UVM	IUPHAR	PURA	SCYL2	0.850445033	1.84E-23
UVM	IUPHAR	PURA	HIPK3	0.85061243	1.76E-23
UVM	IUPHAR	PURA	SLC30A5	0.851853322	1.31E-23
UVM	IUPHAR	PURA	MAP3K2	0.853334619	9.09E-24
UVM	IUPHAR	PURA	NR3C1	0.854292243	7.17E-24
UVM	IUPHAR	PURA	BMPR2	0.854694124	6.49E-24
UVM	IUPHAR	PURA	CLOCK	0.854966489	6.07E-24
UVM	IUPHAR	PURA	CSNK1G3	0.859173778	2.09E-24
UVM	IUPHAR	PURA	NR2C1	0.859173824	2.09E-24
UVM	IUPHAR	PURA	MTR	0.862959649	7.79E-25
UVM	IUPHAR	PURA	FBXO11	0.8637836	6.26E-25
UVM	IUPHAR	PURA	XIAP	0.86486424	4.69E-25
UVM	IUPHAR	PURA	PIK3R1	0.866419747	3.08E-25
UVM	IUPHAR	PURA	XPO1	0.866729588	2.83E-25
UVM	IUPHAR	PURA	USP14	0.866825999	2.76E-25
UVM	IUPHAR	PURA	SMG1	0.873901373	3.77E-26
UVM	IUPHAR	PURA	TNKS2	0.877204159	1.43E-26
UVM	IUPHAR	PURA	PRKAA1	0.888542069	4.08E-28
UVM	IUPHAR	PURA	PIKFYVE	0.914519587	2.16E-32
UVM	Kinase	PURA	JAK2	0.804061679	2.71E-19
UVM	Kinase	PURA	MAPK9	0.805000065	2.29E-19
UVM	Kinase	PURA	IRAK4	0.8068455	1.64E-19
UVM	Kinase	PURA	MAP3K1	0.807689606	1.41E-19
UVM	Kinase	PURA	MAP4K3	0.808224855	1.28E-19
UVM	Kinase	PURA	TBK1	0.816127947	2.90E-20
UVM	Kinase	PURA	TTBK2	0.820306623	1.29E-20
UVM	Kinase	PURA	VRK2	0.821968377	9.28E-21
UVM	Kinase	PURA	MAPK6	0.822384462	8.54E-21
UVM	Kinase	PURA	TAF1	0.823413106	6.95E-21
UVM	Kinase	PURA	PKN2	0.827902333	2.79E-21
UVM	Kinase	PURA	PRPF4B	0.830590647	1.59E-21
UVM	Kinase	PURA	CDK8	0.83093954	1.48E-21
UVM	Kinase	PURA	RIOK3	0.833926781	7.85E-22
UVM	Kinase	PURA	BMPR1A	0.834637011	6.73E-22
UVM	Kinase	PURA	ATM	0.836753395	4.25E-22
UVM	Kinase	PURA	SCYL3	0.837542938	3.58E-22
UVM	Kinase	PURA	DYRK1A	0.840333258	1.92E-22
UVM	Kinase	PURA	TLK1	0.844180264	8.03E-23
UVM	Kinase	PURA	MAPK8	0.845465455	5.96E-23
UVM	Kinase	PURA	NEK7	0.847098299	4.07E-23
UVM	Kinase	PURA	PAN3	0.847766648	3.48E-23
UVM	Kinase	PURA	CDK17	0.847803374	3.45E-23
UVM	Kinase	PURA	SLK	0.848722096	2.77E-23
UVM	Kinase	PURA	CSNK1A1	0.849127305	2.52E-23
UVM	Kinase	PURA	TRPM7	0.850335786	1.88E-23
UVM	Kinase	PURA	SCYL2	0.850445033	1.84E-23
UVM	Kinase	PURA	HIPK3	0.85061243	1.76E-23
UVM	Kinase	PURA	MAP3K2	0.853334619	9.09E-24
UVM	Kinase	PURA	BMPR2	0.854694124	6.49E-24
UVM	Kinase	PURA	CSNK1G3	0.859173778	2.09E-24
UVM	Kinase	PURA	SMG1	0.873901373	3.77E-26
UVM	Kinase	PURA	COL4A3BP	0.875957413	2.07E-26
UVM	Kinase	PURA	PRKAA1	0.888542069	4.08E-28
UVM	TF	PURA	ZNF43	0.80003332	5.52E-19
UVM	TF	PURA	ZNF235	0.801016525	4.64E-19
UVM	TF	PURA	ZNF281	0.802463021	3.60E-19
UVM	TF	PURA	TMF1	0.802512671	3.57E-19
UVM	TF	PURA	ZNF567	0.802802289	3.39E-19
UVM	TF	PURA	THAP1	0.803534221	2.98E-19
UVM	TF	PURA	ZNF248	0.804850139	2.35E-19
UVM	TF	PURA	ZNF25	0.806598131	1.72E-19
UVM	TF	PURA	ZNF24	0.807209124	1.54E-19
UVM	TF	PURA	ZNF845	0.807273367	1.52E-19
UVM	TF	PURA	ZBED5	0.807483748	1.46E-19
UVM	TF	PURA	ZSCAN29	0.807709336	1.40E-19
UVM	TF	PURA	ZNF222	0.807972501	1.34E-19
UVM	TF	PURA	ZNF587	0.80873649	1.16E-19
UVM	TF	PURA	MYSM1	0.809499886	1.01E-19
UVM	TF	PURA	ZNF420	0.809593567	9.92E-20
UVM	TF	PURA	LCOR	0.809911504	9.36E-20
UVM	TF	PURA	ZNF443	0.810066253	9.09E-20
UVM	TF	PURA	ZNF625	0.810768988	7.98E-20
UVM	TF	PURA	FOXN2	0.811481913	6.99E-20
UVM	TF	PURA	PRMT3	0.812316221	5.98E-20
UVM	TF	PURA	ZNF354B	0.812623168	5.65E-20
UVM	TF	PURA	CEBPZ	0.81289191	5.37E-20
UVM	TF	PURA	ZNF143	0.813649644	4.65E-20
UVM	TF	PURA	ZFP14	0.815772903	3.11E-20
UVM	TF	PURA	ZNF26	0.816252813	2.83E-20
UVM	TF	PURA	ZNF280D	0.817279856	2.33E-20
UVM	TF	PURA	BAZ2B	0.817570839	2.20E-20
UVM	TF	PURA	ZNF624	0.817915701	2.06E-20
UVM	TF	PURA	ZNF440	0.818288297	1.91E-20
UVM	TF	PURA	ZNF225	0.818639479	1.79E-20
UVM	TF	PURA	ZNF23	0.819316676	1.57E-20
UVM	TF	PURA	ZNF780B	0.819450901	1.52E-20
UVM	TF	PURA	PURB	0.81963535	1.47E-20
UVM	TF	PURA	PCGF6	0.819642866	1.47E-20
UVM	TF	PURA	ELF2	0.819865556	1.41E-20
UVM	TF	PURA	ZNF461	0.820342799	1.28E-20
UVM	TF	PURA	ZNF510	0.821252975	1.07E-20
UVM	TF	PURA	ZNF14	0.822634176	8.13E-21
UVM	TF	PURA	GABPA	0.822716602	7.99E-21
UVM	TF	PURA	ZNF431	0.82289674	7.71E-21
UVM	TF	PURA	CREBZF	0.822964173	7.61E-21
UVM	TF	PURA	ZNF101	0.823279649	7.14E-21
UVM	TF	PURA	ZNF33A	0.823949251	6.24E-21
UVM	TF	PURA	ZNF527	0.824199566	5.94E-21
UVM	TF	PURA	ZFX	0.824402141	5.70E-21
UVM	TF	PURA	THAP9	0.82478822	5.27E-21
UVM	TF	PURA	HIF1A	0.824975788	5.07E-21
UVM	TF	PURA	ADNP2	0.82505735	4.99E-21
UVM	TF	PURA	ZNF484	0.825091426	4.96E-21
UVM	TF	PURA	LIN54	0.825267795	4.78E-21
UVM	TF	PURA	ZNF223	0.825433321	4.62E-21
UVM	TF	PURA	ZNF28	0.826023525	4.10E-21
UVM	TF	PURA	ZNF181	0.826817089	3.49E-21
UVM	TF	PURA	ZNF585A	0.827583996	2.98E-21
UVM	TF	PURA	ZNF675	0.827901622	2.79E-21
UVM	TF	PURA	ZNF700	0.830013135	1.80E-21
UVM	TF	PURA	ZBTB6	0.830504698	1.62E-21
UVM	TF	PURA	ZNF782	0.830579919	1.60E-21
UVM	TF	PURA	THAP5	0.830802224	1.52E-21
UVM	TF	PURA	ZNF800	0.831846618	1.22E-21
UVM	TF	PURA	AHCTF1	0.832100227	1.16E-21
UVM	TF	PURA	JRKL	0.83211868	1.15E-21
UVM	TF	PURA	ZNF449	0.832293038	1.11E-21
UVM	TF	PURA	IKZF5	0.832457527	1.07E-21
UVM	TF	PURA	ELK3	0.834097274	7.56E-22
UVM	TF	PURA	BACH1	0.834742475	6.58E-22
UVM	TF	PURA	ZNF658	0.835542736	5.53E-22
UVM	TF	PURA	ZNF44	0.836425542	4.57E-22
UVM	TF	PURA	ZNF234	0.837103387	3.94E-22
UVM	TF	PURA	ZNF17	0.839090915	2.54E-22
UVM	TF	PURA	VEZF1	0.840544183	1.83E-22
UVM	TF	PURA	DMTF1	0.842094434	1.29E-22
UVM	TF	PURA	ZNF81	0.843197664	1.01E-22
UVM	TF	PURA	ZNF397	0.845370002	6.10E-23
UVM	TF	PURA	ZNF347	0.845936662	5.34E-23
UVM	TF	PURA	ZNF41	0.846035602	5.22E-23
UVM	TF	PURA	NFXL1	0.846798308	4.37E-23
UVM	TF	PURA	CREB1	0.847930883	3.34E-23
UVM	TF	PURA	ZNF432	0.848151951	3.17E-23
UVM	TF	PURA	TOPORS	0.848519236	2.91E-23
UVM	TF	PURA	ZNF611	0.849186661	2.48E-23
UVM	TF	PURA	ARID2	0.851071446	1.58E-23
UVM	TF	PURA	ZNF45	0.85200776	1.26E-23
UVM	TF	PURA	ZNF236	0.852435879	1.13E-23
UVM	TF	PURA	NR3C1	0.854292243	7.17E-24
UVM	TF	PURA	SMAD4	0.854628769	6.60E-24
UVM	TF	PURA	CLOCK	0.854966489	6.07E-24
UVM	TF	PURA	THAP6	0.855607485	5.17E-24
UVM	TF	PURA	ELF1	0.856725083	3.90E-24
UVM	TF	PURA	ZNF441	0.856969003	3.67E-24
UVM	TF	PURA	ZNF180	0.857876928	2.92E-24
UVM	TF	PURA	ZNF585B	0.858013188	2.82E-24
UVM	TF	PURA	NR2C1	0.859173824	2.09E-24
UVM	TF	PURA	ZNF131	0.859452549	1.95E-24
UVM	TF	PURA	ATF1	0.860416391	1.52E-24
UVM	TF	PURA	ZBTB1	0.861377278	1.18E-24
UVM	TF	PURA	AEBP2	0.861637346	1.10E-24
UVM	TF	PURA	ZNF383	0.862849869	8.02E-25
UVM	TF	PURA	ZNF791	0.863982224	5.94E-25
UVM	TF	PURA	ZNF701	0.86420392	5.60E-25
UVM	TF	PURA	ATF2	0.868723133	1.63E-25
UVM	TF	PURA	GPBP1	0.870390462	1.03E-25
UVM	TF	PURA	YY1	0.871263926	8.02E-26
UVM	TF	PURA	MEF2A	0.874447252	3.22E-26
UVM	TF	PURA	ZNF430	0.874799792	2.90E-26
UVM	TF	PURA	ZNF136	0.879253513	7.72E-27
UVM	TF	PURA	SMAD5	0.884416928	1.55E-27
UVM	TF	PURA	PRDM10	0.890261094	2.30E-28
UVM	TF	PURA	SP3	0.909123352	2.12E-31
UVM	TSG	PURA	RFWD2	0.800819323	4.81E-19
UVM	TSG	PURA	ANXA7	0.800883874	4.75E-19
UVM	TSG	PURA	USP12	0.803870826	2.80E-19
UVM	TSG	PURA	MAPK9	0.805000065	2.29E-19
UVM	TSG	PURA	IFT88	0.805609281	2.05E-19
UVM	TSG	PURA	PALB2	0.806183473	1.85E-19
UVM	TSG	PURA	MSH2	0.807409844	1.48E-19
UVM	TSG	PURA	RB1CC1	0.812560063	5.71E-20
UVM	TSG	PURA	RB1	0.812591136	5.68E-20
UVM	TSG	PURA	APAF1	0.812910069	5.35E-20
UVM	TSG	PURA	SHPRH	0.815849995	3.06E-20
UVM	TSG	PURA	VEZT	0.819531941	1.50E-20
UVM	TSG	PURA	PDS5B	0.820054755	1.35E-20
UVM	TSG	PURA	USP33	0.822892748	7.72E-21
UVM	TSG	PURA	KDM5A	0.823630503	6.66E-21
UVM	TSG	PURA	ITGAV	0.824209827	5.92E-21
UVM	TSG	PURA	HIF1A	0.824975788	5.07E-21
UVM	TSG	PURA	CDKN1B	0.825527238	4.54E-21
UVM	TSG	PURA	CCAR1	0.828603189	2.41E-21
UVM	TSG	PURA	RBL2	0.830532334	1.61E-21
UVM	TSG	PURA	APC	0.83364088	8.34E-22
UVM	TSG	PURA	BMPR1A	0.834637011	6.73E-22
UVM	TSG	PURA	FAM188A	0.834691029	6.66E-22
UVM	TSG	PURA	SIRT1	0.836717489	4.28E-22
UVM	TSG	PURA	ATM	0.836753395	4.25E-22
UVM	TSG	PURA	MLH3	0.837716657	3.44E-22
UVM	TSG	PURA	RINT1	0.838364725	2.98E-22
UVM	TSG	PURA	UHRF2	0.83843361	2.94E-22
UVM	TSG	PURA	DMTF1	0.842094434	1.29E-22
UVM	TSG	PURA	ZMYND11	0.843978135	8.41E-23
UVM	TSG	PURA	GORAB	0.844275031	7.85E-23
UVM	TSG	PURA	INTS6	0.844740914	7.05E-23
UVM	TSG	PURA	TOPORS	0.848519236	2.91E-23
UVM	TSG	PURA	CSNK1A1	0.849127305	2.52E-23
UVM	TSG	PURA	CUL5	0.850586883	1.77E-23
UVM	TSG	PURA	NEDD4	0.851007463	1.60E-23
UVM	TSG	PURA	ARID2	0.851071446	1.58E-23
UVM	TSG	PURA	SMAD4	0.854628769	6.60E-24
UVM	TSG	PURA	BMPR2	0.854694124	6.49E-24
UVM	TSG	PURA	TANK	0.855221816	5.69E-24
UVM	TSG	PURA	CHD1	0.85663845	3.99E-24
UVM	TSG	PURA	DICER1	0.856646957	3.98E-24
UVM	TSG	PURA	PPM1A	0.857153766	3.50E-24
UVM	TSG	PURA	GGNBP2	0.86498518	4.54E-25
UVM	TSG	PURA	DCLRE1A	0.867656611	2.19E-25
UVM	TSG	PURA	CDC73	0.87040468	1.02E-25
UVM	TSG	PURA	CUL2	0.876838903	1.59E-26
UVM	TSG	PURA	KRIT1	0.884136164	1.70E-27
UVM	TSG	PURA	SMCHD1	0.885287036	1.18E-27
UVM	TSG	PURA	PRKAA1	0.888542069	4.08E-28
UVM	TSG	PURA	SUZ12	0.892698923	1.00E-28
UVM	TSG	PURA	WDR11	0.893951237	6.52E-29

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KICH	PURA	MCM3	1.2290616304957	0.000139892101287842
HNSC	PURA	MDH2	-1.45585792727916	0.000172794781747143
KIRP	PURA	ADK	2.08238981108007	0.000256400555372238
KICH	PURA	FMR1	1.78310178813069	0.00102710723876953
KIRP	PURA	MCM3	-1.56591780212902	0.00114433001726866
CHOL	PURA	GNPTAB	-1.80323590085181	0.00390625
CHOL	PURA	POLA1	-4.88892725298085	0.00390625
ESCA	PURA	MCM3	-5.39465050378002	0.0048828125
LUAD	PURA	ADK	1.48831421398514	0.00570943489529292
KIRP	PURA	FMR1	-1.94284822624948	0.0099095250479877
KIRP	PURA	PURB	-1.86872949474321	0.0105091729201376
KICH	PURA	POLA1	-1.26246857559379	0.0159729719161987
HNSC	PURA	PURB	1.02870794213712	0.0165749692632744
CHOL	PURA	PURB	-2.11234621921319	0.01953125
BRCA	PURA	GNPTAB	1.19421663279783	0.023899962130957
BRCA	PURA	FMR1	-2.74053611255086	0.0481383834499222
KIRC	PURA	FMR1	-2.35406916543664	1.12145348829767e-07
LUAD	PURA	GNPTAB	-1.16447936488855	1.13396900342584e-05
LIHC	PURA	MCM3	-1.82226452227398	1.19014679269443e-09
HNSC	PURA	FMR1	-2.72606987034586	1.37760207508109e-06
LIHC	PURA	MCM8	-1.3774946195887	2.17397650760512e-07
BRCA	PURA	MDH2	-1.47172542006104	2.17909214563582e-11
LUAD	PURA	MCM3	-2.24148646159616	3.16320496270304e-09
BRCA	PURA	POLA1	1.31561227665508	3.7777772677383e-05
LUAD	PURA	MCM8	-11.4328703613687	4.36641792271383e-10
LIHC	PURA	ADK	-1.5767090931262	4.64150644319947e-09
BRCA	PURA	YBX1	1.10467241966451	4.8741280959683e-05
LUAD	PURA	MDH2	-3.03739491193752	5.31997757053803e-10
COAD	PURA	ADK	-4.93881643110831	5.38075767948408e-05
KIRC	PURA	MCM8	1.61444853764618	6.02390727604811e-08
LUAD	PURA	POLA1	-1.91310177817187	6.05809956862828e-05
KICH	PURA	YBX1	1.86923259160472	8.16583633422851e-06

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with PURA

CNBP, CCNT1, SP1, E2F1, HNRNPA1, MEPCE, UBC, POU5F1, EIF2AK2, CUL3, CUL1, CAND1, PURB, ZNF638, RFC3, DDX23, RFC2, POLA1, RB1, IL7R, IGSF8, ICAM1, TARDBP, LIN28A, LIN28B, RAF1, BMI1, SURF2, ZC3H3, RPS8, PRR11, NTRK1, SNW1, WDR46, ZCRB1, HIST1H1E, RRS1, G3BP1, HNRNPL, TRIM14, TNIP2, RIOK1, LARP7, AGO2, SNAI1, HRAS, HABP4, SERBP1, MB21D1, WDR76, HIST1H4A, HIST1H2BB, HIST1H2AB, RAB11A, RC3H1, RC3H2, ATG16L1, OASL, P2RY6, SNRNP70, tat, BRD7, ARIH2, PLEKHA4, PTEN, MIRLET7A1, MIRLET7A3, MIRLET7B, MIRLET7C, MIRLET7D, MIRLET7E, MIRLET7F1, MIRLET7F2, MIRLET7G, MIRLET7I, MIR1-1, MIR7-1, MIR7-2, MIR9-2, MIR15B, MIR16-2, MIR17, MIR18B, MIR19A, MIR19B1, MIR19B2, MIR20B, MIR21, MIR25, MIR29B1, MIR29C, MIR31, MIR34A, MIR34B, MIR34C, MIR92A2, MIR93, MIR106B, MIR122, MIR128-1, MIR128-2, MIR140, MIR143, MIR155, MIR199A1, MIR200C, MIR205, MIR221, MIR222, MIR363, MIR429, ZC3H18, ESR1, MAD2L2, KIF23, MKI67, ZNF263, MAFB, RBM39, MKRN1, IFI16, CUL4A, NHP2, OGT, DDRGK1, FZR1, SRSF5, FAM120A, NEIL1, RPL19, ABT1, HIST1H2AM, RPL17, ADARB1, MAGEB2, HIST1H1C, RPS10, RPL23AP32, LLPH, H2AFB2, HIST1H1B, MYBBP1A, RPL23A, H2AFB3, PRR3, SRSF3, HIST2H2AC, RBM19, DDX21, LYAR, SRSF6, RSL1D1, RPS19, FGF8, REXO4, RPS6, HIST1H1D, YBX2, KRR1, RPL15, RBMS2, SRSF4, RPSAP58, PURG, RPS3, DGCR8, RPL13, RPL3, ZNF668, RPLP0, SURF6, RPL31, ZNF71, ZNF346, RPL35, RPL14, PRKRA, RPSA, RNF151, RPL13A, RRP9, FGFBP1, HIST1H1A, RPL4, EP300, FBXW7, TMPRSS11B, TMPRSS4, CPEB1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
PURA	chr5	139493745	CGCGGCAGCGGAGCGCAGCATCATGGCGGACCGAGACA	C	Deletion	Likely_pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001582\|initiatior_codon_variant,SO:0001589\|frameshift_variant	SO:0001582\|initiatior_codon_variant,SO:0001589\|frameshift_variant
PURA	chr5	139493767	A	G	single_nucleotide_variant	Pathogenic	Mental_retardation,_autosomal_dominant_31\|not_provided	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant
PURA	chr5	139493767	A	T	single_nucleotide_variant	Pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant
PURA	chr5	139493769	GGCGGA	G	Deletion	Pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139493770	GCGGAC	G	Deletion	Pathogenic	Inborn_genetic_diseases	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139493772	G	GGACC	Duplication	Pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139493776	C	T	single_nucleotide_variant	Pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001587\|nonsense	SO:0001587\|nonsense
PURA	chr5	139493780	AC	A	Deletion	Likely_pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139493780	ACAGCGGCAGCG	C	Indel	Pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139493793	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139493800	G	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139493802	TGCGGCGCTGGGTTCGG	T	Deletion	Pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139493803	GC	G	Deletion	Pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139493806	G	C	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Mental_retardation,_autosomal_dominant_31\|History_of_neurodevelopmental_disorder	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139493808	G	A	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139493809	C	A	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139493810	T	TGGGTTCGGGCGGCTCC	Duplication	Pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139493815	TC	T	Deletion	Likely_pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139493816	C	CG	Duplication	Pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139493817	G	C	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139493817	G	T	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139493824	T	C	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139493828	T	TG	Duplication	Pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139493828	TG	T	Deletion	Likely_pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139493829	G	T	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139493836	C	G	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139493836	C	T	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139493838	C	CGGCTCG	Duplication	Conflicting_interpretations_of_pathogenicity	Mental_retardation,_autosomal_dominant_31\|not_provided	SO:0001821\|inframe_insertion	SO:0001821\|inframe_insertion
PURA	chr5	139493839	G	A	single_nucleotide_variant	Uncertain_significance	History_of_neurodevelopmental_disorder	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139493843	C	A	single_nucleotide_variant	Pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001587\|nonsense	SO:0001587\|nonsense
PURA	chr5	139493848	T	C	single_nucleotide_variant	Uncertain_significance	Inborn_genetic_diseases	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139493850	AGGCTCC	A	Deletion	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001822\|inframe_deletion	SO:0001822\|inframe_deletion
PURA	chr5	139493855	C	CCGGCGGGGGCGGTGGTGG	Duplication	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001821\|inframe_insertion	SO:0001821\|inframe_insertion
PURA	chr5	139493855	CCGGCGGGGGCGGTGGTGG	C	Deletion	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001822\|inframe_deletion	SO:0001822\|inframe_deletion
PURA	chr5	139493858	GC	G	Deletion	Pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139493859	CG	C	Deletion	Pathogenic	Epileptic_encephalopathy\|not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139493862	GGGCGGTGGTGGC	G	Deletion	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001822\|inframe_deletion	SO:0001822\|inframe_deletion
PURA	chr5	139493865	CG	C	Deletion	Pathogenic	Inborn_genetic_diseases	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139493866	G	A	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139493866	GGTGGTGGCGGCGGGGGCGGCGGCGGCA	G	Deletion	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001822\|inframe_deletion	SO:0001822\|inframe_deletion
PURA	chr5	139493871	T	C	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31\|History_of_neurodevelopmental_disorder	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139493871	T	TGGCGGCGGG	Duplication	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001821\|inframe_insertion	SO:0001821\|inframe_insertion
PURA	chr5	139493871	TGGCGGCGGG	T	Deletion	Conflicting_interpretations_of_pathogenicity	Mental_retardation,_autosomal_dominant_31\|History_of_neurodevelopmental_disorder\|not_provided	SO:0001822\|inframe_deletion	SO:0001822\|inframe_deletion
PURA	chr5	139493871	TGGCGGCGGGGGCGGCGGCGGCAGTGGC	T	Deletion	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001822\|inframe_deletion	SO:0001822\|inframe_deletion
PURA	chr5	139493871	TGGCGGCGGGGGCGGCGGCGGCAGTGGCGGCGGC	T	Deletion	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001822\|inframe_deletion	SO:0001822\|inframe_deletion
PURA	chr5	139493875	G	T	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139493876	G	C	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_autosomal_dominant_31\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139493877	C	CG	Duplication	Pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139493880	G	GGGCGGCGGCGGCAGT	Duplication	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001821\|inframe_insertion	SO:0001821\|inframe_insertion
PURA	chr5	139493880	G	GGGCGGCGGCGGCAGTGGCGGC	Duplication	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001821\|inframe_insertion	SO:0001821\|inframe_insertion
PURA	chr5	139493880	GGGCGGCGGCGGCAGT	G	Deletion	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001822\|inframe_deletion	SO:0001822\|inframe_deletion
PURA	chr5	139493880	GGGCGGCGGCGGCAGTGGCGGCGGC	G	Deletion	Likely_benign	Mental_retardation,_autosomal_dominant_31\|not_provided	SO:0001822\|inframe_deletion	SO:0001822\|inframe_deletion
PURA	chr5	139493883	C	CGGCGGCGGCAGT	Duplication	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001821\|inframe_insertion	SO:0001821\|inframe_insertion
PURA	chr5	139493883	CG	C	Deletion	Pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139493883	CGGCGGCGGCAGT	C	Deletion	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001822\|inframe_deletion	SO:0001822\|inframe_deletion
PURA	chr5	139493887	G	GGCGGCA	Duplication	Conflicting_interpretations_of_pathogenicity	Mental_retardation,_autosomal_dominant_31\|not_specified\|not_provided	SO:0001821\|inframe_insertion	SO:0001821\|inframe_insertion
PURA	chr5	139493892	CAGTG	C	Deletion	Pathogenic	Inborn_genetic_diseases	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139493893	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139493895	T	TGGC	Microsatellite	Conflicting_interpretations_of_pathogenicity	Mental_retardation,_autosomal_dominant_31\|History_of_neurodevelopmental_disorder\|not_specified\|not_provided	SO:0001821\|inframe_insertion	SO:0001821\|inframe_insertion
PURA	chr5	139493895	T	TGGCGGC	Microsatellite	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001821\|inframe_insertion	SO:0001821\|inframe_insertion
PURA	chr5	139493895	TGGC	T	Microsatellite	Benign/Likely_benign	Mental_retardation,_autosomal_dominant_31\|not_provided	SO:0001822\|inframe_deletion	SO:0001822\|inframe_deletion
PURA	chr5	139493895	TGGCGGC	T	Microsatellite	Uncertain_significance	Mental_retardation,_autosomal_dominant_31\|not_provided	SO:0001822\|inframe_deletion	SO:0001822\|inframe_deletion
PURA	chr5	139493895	TGGCGGCGGC	T	Microsatellite	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001822\|inframe_deletion	SO:0001822\|inframe_deletion
PURA	chr5	139493901	CG	C	Deletion	Likely_pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139493904	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139493907	C	T	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139493909	GC	G	Deletion	Pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139493910	CG	C	Deletion	Pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139493911	G	GGGGCCCCA	Duplication	Pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139493912	G	T	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_autosomal_dominant_31\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139493918	CA	C	Deletion	Pathogenic	Inborn_genetic_diseases\|History_of_neurodevelopmental_disorder	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139493919	A	AG	Duplication	Pathogenic	Intellectual_disability\|PURA-related_severe_neonatal_hypotonia-seizures-encephalopathy_syndrome_due_to_a_point_mutation\|Mental_retardation,_autosomal_dominant_31\|not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139493921	G	A	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139493921	G	T	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139493929	C	T	single_nucleotide_variant	Pathogenic	Mental_retardation,_autosomal_dominant_31\|not_provided	SO:0001587\|nonsense	SO:0001587\|nonsense
PURA	chr5	139493931	G	A	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139493934	C	CGA	Microsatellite	Pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139493935	G	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139493939	C	CT	Insertion	Pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139493941	C	T	single_nucleotide_variant	Pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001587\|nonsense	SO:0001587\|nonsense
PURA	chr5	139493944	G	T	single_nucleotide_variant	Pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001587\|nonsense	SO:0001587\|nonsense
PURA	chr5	139493968	A	G	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139493971	C	T	single_nucleotide_variant	Pathogenic	Mental_retardation,_autosomal_dominant_31\|not_provided	SO:0001587\|nonsense	SO:0001587\|nonsense
PURA	chr5	139493977	A	G	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139493987	A	G	single_nucleotide_variant	Likely_pathogenic	See_cases	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139493990	T	C	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139493990	T	G	single_nucleotide_variant	Pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139493994	C	T	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139493997	G	T	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494006	C	T	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31\|History_of_neurodevelopmental_disorder	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494007	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494011	AG	A	Deletion	Likely_pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494021	C	T	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494028	ATCG	A	Deletion	Pathogenic	Intellectual_disability\|Delayed_speech_and_language_development\|Global_developmental_delay\|Seizures\|Neonatal_hypotonia	SO:0001820\|inframe_indel	SO:0001820\|inframe_indel
PURA	chr5	139494029	T	C	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494029	TC	T	Deletion	Pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494031	G	A	single_nucleotide_variant	Uncertain_significance	Neurodevelopmental_disorder	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494031	G	C	single_nucleotide_variant	Pathogenic	Intellectual_disability\|Delayed_speech_and_language_development\|Global_developmental_delay\|Seizures\|Neonatal_hypotonia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494031	GC	G	Deletion	Pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494033	C	T	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494034	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494034	G	C	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494036	G	A	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494044	C	T	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494044	CG	C	Deletion	Pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494045	G	A	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494055	A	G	single_nucleotide_variant	Pathogenic	Intellectual_disability\|Delayed_speech_and_language_development\|Global_developmental_delay\|Seizures\|Neonatal_hypotonia\|Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494063	CCTTACTCTCTCCATGTCA	C	Deletion	Likely_pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001822\|inframe_deletion	SO:0001822\|inframe_deletion
PURA	chr5	139494065	T	C	single_nucleotide_variant	Likely_pathogenic	Intellectual_disability\|Delayed_speech_and_language_development\|Global_developmental_delay\|Seizures\|Neonatal_hypotonia\|Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494066	T	G	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494066	TACTCTCTCC	T	Deletion	Pathogenic	Mental_retardation,_autosomal_dominant_31\|not_provided	SO:0001822\|inframe_deletion	SO:0001822\|inframe_deletion
PURA	chr5	139494067	A	ACT	Microsatellite	Pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494067	ACT	A	Microsatellite	Pathogenic	Intellectual_disability\|Delayed_speech_and_language_development\|Global_developmental_delay\|Neonatal_hypotonia\|Mental_retardation,_autosomal_dominant_31	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494069	T	G	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494071	T	C	single_nucleotide_variant	Likely_pathogenic	Inborn_genetic_diseases	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494071	T	G	single_nucleotide_variant	Pathogenic	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494072	C	T	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494077	TG	T	Deletion	Pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494081	A	G	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494087	C	G	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494087	C	T	single_nucleotide_variant	Benign/Likely_benign	Mental_retardation,_autosomal_dominant_31\|History_of_neurodevelopmental_disorder\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494091	G	T	single_nucleotide_variant	Pathogenic	not_provided	SO:0001587\|nonsense	SO:0001587\|nonsense
PURA	chr5	139494100	G	C	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494105	C	G	single_nucleotide_variant	Pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001587\|nonsense	SO:0001587\|nonsense
PURA	chr5	139494116	T	C	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494128	A	ACG	Microsatellite	Pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494129	C	G	single_nucleotide_variant	Pathogenic	Intellectual_disability\|Delayed_speech_and_language_development\|Global_developmental_delay\|Seizures\|Neonatal_hypotonia\|not_provided	SO:0001587\|nonsense	SO:0001587\|nonsense
PURA	chr5	139494133	C	T	single_nucleotide_variant	Pathogenic	not_provided	SO:0001587\|nonsense	SO:0001587\|nonsense
PURA	chr5	139494135	G	A	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494141	C	G	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494142	C	CCCAG	Microsatellite	Likely_pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494144	C	CA	Duplication	Pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494146	G	GC	Duplication	Pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494151	C	T	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494153	G	A	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494153	G	C	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494156	G	A	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494156	G	C	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494160	C	G	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494165	C	G	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494168	G	GGCGCAGGACGAGCC	Duplication	Likely_pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494170	CGCAGGACGAGCCGCGCCGGGCGCTCAAAA	C	Deletion	Pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494172	C	T	single_nucleotide_variant	Pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001587\|nonsense	SO:0001587\|nonsense
PURA	chr5	139494185	G	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494187	C	A	single_nucleotide_variant	Likely_benign	History_of_neurodevelopmental_disorder	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494187	C	CG	Duplication	Pathogenic	PURA_Syndrome	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494192	G	A	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494193	C	G	single_nucleotide_variant	Uncertain_significance	Inborn_genetic_diseases	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494196	A	G	single_nucleotide_variant	Likely_pathogenic	Intellectual_disability\|Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494198	A	C	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494198	A	G	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494213	GCGCGAGAA	G	Deletion	Likely_pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494216	C	CGAGAACCGCAAGTACTACATGGATCTCAAG	Duplication	Likely_pathogenic	Inborn_genetic_diseases	SO:0001821\|inframe_insertion	SO:0001821\|inframe_insertion
PURA	chr5	139494216	C	G	single_nucleotide_variant	Benign/Likely_benign	Mental_retardation,_autosomal_dominant_31\|History_of_neurodevelopmental_disorder\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494216	C	T	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494217	G	T	single_nucleotide_variant	Pathogenic	not_provided	SO:0001587\|nonsense	SO:0001587\|nonsense
PURA	chr5	139494224	G	C	single_nucleotide_variant	Pathogenic	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494224	G	GC	Duplication	Pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494228	G	A	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494231	C	T	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494236	T	A	single_nucleotide_variant	Pathogenic	Intellectual_disability\|Delayed_speech_and_language_development\|Global_developmental_delay\|Neonatal_hypotonia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494238	G	T	single_nucleotide_variant	Likely_pathogenic	Inborn_genetic_diseases	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494241	C	G	single_nucleotide_variant	Uncertain_significance	Inborn_genetic_diseases	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494243	C	G	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494243	CAAG	C	Deletion	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001822\|inframe_deletion	SO:0001822\|inframe_deletion
PURA	chr5	139494244	A	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494246	G	A	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494250	A	G	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494252	C	G	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494253	C	T	single_nucleotide_variant	Pathogenic	Mental_retardation,_autosomal_dominant_31\|not_provided	SO:0001587\|nonsense	SO:0001587\|nonsense
PURA	chr5	139494257	G	GCGGC	Duplication	Pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494258	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494259	G	A	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494259	G	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494260	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494261	C	G	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494262	C	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494262	C	T	single_nucleotide_variant	Likely_pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494264	C	G	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494266	T	TC	Duplication	Pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494267	C	G	single_nucleotide_variant	Uncertain_significance	Global_developmental_delay-visual_anomalies-progressive_cerebellar_atrophy-truncal_hypotonia_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494269	T	C	single_nucleotide_variant	Likely_pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494270	GC	TT	Indel	Uncertain_significance	not_specified	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494272	G	C	single_nucleotide_variant	Pathogenic	Inborn_genetic_diseases	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494272	GCATCCGC	G	Deletion	Pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494275	T	G	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494277	C	G	single_nucleotide_variant	Likely_pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494283	A	G	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494284	C	A	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494285	G	C	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494291	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494292	CG	C	Deletion	Pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494294	G	C	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494294	G	GGGGCCTGGCCTGGGCTCCACGCA	Duplication	Pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494297	G	C	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31\|History_of_neurodevelopmental_disorder	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494297	G	GC	Duplication	Pathogenic	Inborn_genetic_diseases	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494298	C	CCTGGCCTGGGCTCCACGCAGGG	Duplication	Likely_pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494300	T	G	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494303	C	G	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494303	C	T	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494309	C	A	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494309	C	T	single_nucleotide_variant	Benign/Likely_benign	Mental_retardation,_autosomal_dominant_31\|History_of_neurodevelopmental_disorder\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494322	C	T	single_nucleotide_variant	Pathogenic	Intellectual_disability\|Delayed_speech_and_language_development\|Global_developmental_delay\|Seizures\|Neonatal_hypotonia\|Mental_retardation,_autosomal_dominant_31	SO:0001587\|nonsense	SO:0001587\|nonsense
PURA	chr5	139494326	CCATTGCGCTGCCCGCG	C	Deletion	Likely_pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494329	T	C	single_nucleotide_variant	Likely_pathogenic	Mental_retardation,_autosomal_dominant_31\|Inborn_genetic_diseases	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494330	T	C	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494331	G	C	single_nucleotide_variant	Likely_pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494338	C	T	single_nucleotide_variant	Likely_pathogenic	Inborn_genetic_diseases\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494339	C	G	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494342	G	T	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494348	G	C	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494348	G	T	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31\|not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494350	T	A	single_nucleotide_variant	Uncertain_significance	Inborn_genetic_diseases	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494351	C	G	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494361	C	T	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494362	G	C	single_nucleotide_variant	Pathogenic/Likely_pathogenic	Intellectual_disability\|Delayed_speech_and_language_development\|Global_developmental_delay\|Seizures\|Neonatal_hypotonia\|Mental_retardation,_autosomal_dominant_31\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494363	T	C	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494369	T	C	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494369	T	G	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494371	T	C	single_nucleotide_variant	Likely_pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494374	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494379	CTCA	C	Deletion	Likely_pathogenic	not_provided	SO:0001822\|inframe_deletion	SO:0001822\|inframe_deletion
PURA	chr5	139494380	T	C	single_nucleotide_variant	Likely_pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494381	C	T	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494382	A	T	single_nucleotide_variant	Pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494384	C	T	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494384	CGACGACT	C	Deletion	Pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494387	C	T	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Mental_retardation,_autosomal_dominant_31\|History_of_neurodevelopmental_disorder\|not_specified\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494396	A	C	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494400	G	C	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494404	A	T	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494405	G	GGAGCC	Duplication	Pathogenic	Inborn_genetic_diseases	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494406	G	T	single_nucleotide_variant	Pathogenic/Likely_pathogenic	Generalized_hypotonia\|Apnea\|Limb_dystonia\|Mental_retardation,_autosomal_dominant_31	SO:0001587\|nonsense	SO:0001587\|nonsense
PURA	chr5	139494411	GGCCGAGCTGCCCGA	G	Deletion	Pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494414	C	T	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494423	C	T	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494435	C	T	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494440	C	T	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494440	CTG	C	Microsatellite	Pathogenic	Intellectual_disability\|Mental_retardation,_autosomal_dominant_31\|Inborn_genetic_diseases\|not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494443	T	TGGACTGA	Insertion	Pathogenic	Inborn_genetic_diseases	SO:0001587\|nonsense	SO:0001587\|nonsense
PURA	chr5	139494451	A	T	single_nucleotide_variant	Pathogenic	not_provided	SO:0001587\|nonsense	SO:0001587\|nonsense
PURA	chr5	139494455	GCTT	G	Microsatellite	Pathogenic/Likely_pathogenic	Mental_retardation,_autosomal_dominant_31\|Inborn_genetic_diseases\|not_provided	SO:0001822\|inframe_deletion	SO:0001822\|inframe_deletion
PURA	chr5	139494458	T	C	single_nucleotide_variant	Pathogenic	Inborn_genetic_diseases	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494459	C	T	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494462	C	T	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494468	T	C	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494468	TG	T	Deletion	Pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494470	T	G	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494475	T	TC	Duplication	Pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494476	C	T	single_nucleotide_variant	Likely_pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494480	CA	C	Deletion	Pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494486	C	G	single_nucleotide_variant	Pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001587\|nonsense	SO:0001587\|nonsense
PURA	chr5	139494489	CGT	C	Microsatellite	Pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494490	G	GT	Duplication	Pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494492	G	C	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494495	T	C	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494499	C	T	single_nucleotide_variant	Pathogenic	not_provided	SO:0001587\|nonsense	SO:0001587\|nonsense
PURA	chr5	139494500	G	C	single_nucleotide_variant	Pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494501	A	G	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494507	C	T	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494509	AG	A	Deletion	Pathogenic	not_provided	SO:0001587\|nonsense	SO:0001587\|nonsense
PURA	chr5	139494525	T	C	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494535	A	G	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494543	G	A	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494543	G	C	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494545	C	G	single_nucleotide_variant	Likely_pathogenic	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494545	C	T	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Mental_retardation,_autosomal_dominant_31\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494549	C	G	single_nucleotide_variant	Pathogenic	Intellectual_disability\|Delayed_speech_and_language_development\|Global_developmental_delay\|Seizures\|Neonatal_hypotonia	SO:0001587\|nonsense	SO:0001587\|nonsense
PURA	chr5	139494551	AGGT	A	Deletion	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001822\|inframe_deletion	SO:0001822\|inframe_deletion
PURA	chr5	139494555	G	C	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494568	G	T	single_nucleotide_variant	Pathogenic	not_provided	SO:0001587\|nonsense	SO:0001587\|nonsense
PURA	chr5	139494569	GAC	G	Microsatellite	Likely_pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494570	A	C	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494570	A	G	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494575	CCTT	C	Deletion	Pathogenic	Intellectual_disability\|Delayed_speech_and_language_development\|Global_developmental_delay\|Seizures\|Neonatal_hypotonia\|Mental_retardation,_autosomal_dominant_31\|not_provided	SO:0001822\|inframe_deletion	SO:0001822\|inframe_deletion
PURA	chr5	139494592	G	T	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001587\|nonsense	SO:0001587\|nonsense
PURA	chr5	139494607	AT	A	Deletion	Likely_pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494645	GCAGCTTCAC	G	Deletion	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001822\|inframe_deletion	SO:0001822\|inframe_deletion
PURA	chr5	139494660	G	GC	Duplication	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494663	A	ACAG	Microsatellite	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001821\|inframe_insertion	SO:0001821\|inframe_insertion
PURA	chr5	139494663	AC	A	Deletion	Likely_pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494684	C	G	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494684	C	T	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PURA	chr5	139494685	G	A	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494686	C	T	single_nucleotide_variant	Likely_benign	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494688	G	A	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494688	GCTGCCACCCTGCTA	G	Deletion	Pathogenic	Inborn_genetic_diseases	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PURA	chr5	139494691	G	C	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494707	A	C	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494716	A	T	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_autosomal_dominant_31	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494721	G	C	single_nucleotide_variant	Uncertain_significance	Intellectual_disability	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PURA	chr5	139494754	C	CCA	Microsatellite	Benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
PURA	LUAD	chr5	139493896	139493898	GGC	-	In_Frame_Del	p.G49del	4
PURA	PAAD	chr5	139494240	139494240	T	G	Missense_Mutation	p.D158E	3
PURA	STAD	chr5	139494404	139494404	A	C	Missense_Mutation	p.E213A	2
PURA	BLCA	chr5	139494256	139494256	C	T	Missense_Mutation	p.R164C	2
PURA	ESCA	chr5	139494603	139494603	G	A	Silent		2
PURA	PAAD	chr5	139494240	139494240	T	G	Missense_Mutation		2
PURA	ESCA	chr5	139494603	139494603	G	A	Silent	p.K279K	2
PURA	CESC	chr5	139494400	139494400	G	C	Missense_Mutation		2
PURA	LGG	chr5	139494544	139494544	C	T	Missense_Mutation	p.P260S	1
PURA	BLCA	chr5	139494469	139494469	G	T	Missense_Mutation	p.V235L	1
PURA	SKCM	chr5	139494291	139494291	C	T	Silent	p.N175N	1
PURA	CESC	chr5	139494400	139494400	G	C	Missense_Mutation	p.E212Q	1
PURA	LGG	chr5	139494544	139494544	C	T	Missense_Mutation		1
PURA	BLCA	chr5	139494494	139494494	T	G	Missense_Mutation	p.F243C	1
PURA	SKCM	chr5	139494086	139494086	C	T	Missense_Mutation	p.A107V	1
PURA	COAD	chr5	139494754	139494755	-	CA	3'UTR	.	1
PURA	LIHC	chr5	139494721	139494721	G	-	Frame_Shift_Del	p.G319fs	1
PURA	BLCA	chr5	139494117	139494117	C	T	Silent	p.F117F	1
PURA	SKCM	chr5	139494456	139494458	CTT	-	In_Frame_Del	p.RF230del	1
PURA	COAD	chr5	139494992	139494993	-	A	3'UTR	.	1
PURA	LUAD	chr5	139494510	139494510	G	T	Missense_Mutation	p.E248D	1
PURA	BLCA	chr5	139494643	139494643	G	A	Missense_Mutation	p.E293K	1
PURA	ESCA	chr5	139494597	139494597	G	T	Missense_Mutation	p.E277D	1
PURA	BLCA	chr5	139494615	139494615	G	A	Silent		1
PURA	BLCA	chr5	139494276	139494276	C	T	Silent	p.I170I	1
PURA	THCA	chr5	139494097	139494098	-	A	Frame_Shift_Ins	p.R111fs	1
PURA	ESCA	chr5	139494603	139494603	G	A	Silent	p.K279	1
PURA	BLCA	chr5	139494494	139494494	T	G	Missense_Mutation		1
PURA	LUSC	chr5	139494223	139494223	C	T	Missense_Mutation	p.R153C	1
PURA	BLCA	chr5	139494643	139494643	G	A	Missense_Mutation		1
PURA	BLCA	chr5	139494639	139494639	C	G	Silent	p.A291A	1
PURA	ESCA	chr5	139494597	139494597	G	T	Missense_Mutation		1
PURA	BLCA	chr5	139494276	139494276	C	T	Silent		1
PURA	BLCA	chr5	139494679	139494679	G	T	Nonsense_Mutation	p.E305*	1
PURA	BLCA	chr5	139494256	139494256	C	T	Missense_Mutation		1
PURA	SARC	chr5	139494445	139494445	G	T	Missense_Mutation		1
PURA	CESC	chr5	139494072	139494072	C	T	Silent		1
PURA	HNSC	chr5	139494356	139494356	A	T	Missense_Mutation		1
PURA	BLCA	chr5	139494639	139494639	C	G	Silent		1
PURA	SKCM	chr5	139494456	139494458	CTT	-	In_Frame_Del	p.230_231del	1
PURA	LGG	chr5	139494027	139494027	G	A	Silent	p.K87K	1
PURA	BLCA	chr5	139494615	139494615	G	A	Silent	p.E283E	1
PURA	SKCM	chr5	139494170	139494170	C	A	Missense_Mutation	p.A135E	1
PURA	CESC	chr5	139494132	139494132	G	A	Silent		1

Copy number variation (CNV) of PURA
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across PURA
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
47532	N/A	T24782	DLGAP5	chr14	55629743	+	PURA	chr5	139494921	+
81471	N/A	CF140519	PURA	chr5	139493698	-	ARPC5L	chr9	127631472	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	PURA	0.00064393078252913	0.018
LIHC	PURA	0.0133500373958524	0.36
SARC	PURA	0.030457721537377	0.79
KIRP	PURA	0.0388605663567721	0.97
READ	PURA	0.0436053783783048	1
COAD	PURA	0.0446992948389884	1
THCA	PURA	0.0452979989434288	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
STAD	PURA	0.00297931752804657	0.092
LUAD	PURA	0.000558332510055145	0.018
THCA	PURA	0.00774796565944178	0.23
LGG	PURA	0.0125019242656711	0.36
BRCA	PURA	0.000344859519810468	0.011
PCPG	PURA	0.0363942823149639	0.98
THYM	PURA	0.0148296305268564	0.42

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C4015357	MENTAL RETARDATION, AUTOSOMAL DOMINANT 31	2	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
C0014544	Epilepsy	1	CTD_human
C0086237	Epilepsy, Cryptogenic	1	CTD_human
C0751111	Awakening Epilepsy	1	CTD_human