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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RARA (NCBI Gene ID:5914)

Gene Summary

Gene Summary

Gene Information	Gene Name: RARA
	Gene ID: 5914
	Gene Symbol	RARA
	Gene ID	5914
	Gene Name	retinoic acid receptor alpha
	Synonyms	NR1B1\|RAR
	Cytomap	17q21.2
	Type of Gene	protein-coding
	Description	retinoic acid receptor alphaRAR-alphanuclear receptor subfamily 1 group B member 1nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long formretinoic acid nuclear receptor alpha variant 1retinoic acid nuclear receptor alpha variant 2
	Modification date	20200327
	UniProtAcc	P10276

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RARA	GO:0007165	signal transduction	2825025
Hgene	RARA	GO:0030853	negative regulation of granulocyte differentiation	19917671
Hgene	RARA	GO:0032689	negative regulation of interferon-gamma production	18416830
Hgene	RARA	GO:0032720	negative regulation of tumor necrosis factor production	18416830
Hgene	RARA	GO:0032736	positive regulation of interleukin-13 production	18416830
Hgene	RARA	GO:0032753	positive regulation of interleukin-4 production	18416830
Hgene	RARA	GO:0032754	positive regulation of interleukin-5 production	18416830
Hgene	RARA	GO:0045630	positive regulation of T-helper 2 cell differentiation	18416830
Hgene	RARA	GO:0045892	negative regulation of transcription, DNA-templated	20080953
Hgene	RARA	GO:0045893	positive regulation of transcription, DNA-templated	18845237\|19850744\|20080953
Hgene	RARA	GO:0045944	positive regulation of transcription by RNA polymerase II	19850744\|21131358
Hgene	RARA	GO:0071300	cellular response to retinoic acid	19917671
Hgene	RARA	GO:0071391	cellular response to estrogen stimulus	20080953

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'RARA[title] AND translation [title] AND human.'

Gene	Title	PMID
RARA	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000254066	38487108	38487648	5CDS-5UTR
ENST00000394089	38487108	38487648	5CDS-5UTR
ENST00000254066	38504567	38504716	Frame-shift
ENST00000394089	38504567	38504716	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LIHC	RARA	1.13748187698501	0.0180274774396286
PRAD	RARA	1.34219419296503	2.33522234893958e-05
LUAD	RARA	-2.47510375703787	2.71315593655732e-08
KICH	RARA	2.81171799556023	8.80360603332519e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
ACC	RARA	hsa-miR-218-5p	98	-0.347103213242454	0.00182600029771333
UCS	RARA	hsa-miR-135b-5p	93	-0.321394395078606	0.0160854310601084
UCS	RARA	hsa-miR-205-5p	82	-0.315721120984279	0.0181420571550535

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
HNSC	RARA	2	1	0.0346316420320247	0.333868161634103	0.172883203125	-0.518380225576395	-0.1267179365

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
BRCA	RARA	-0.086135549	0.004545151
TGCT	RARA	-0.065206716	0.027489439

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RARA (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
KICH	CGC	RARA	LMNA	0.804537047	7.56E-22
KICH	TF	RARA	ARID5A	0.838159258	3.72E-25
TGCT	Cell metabolism gene	RARA	F10	0.80680449	5.05E-37
TGCT	Cell metabolism gene	RARA	PDK2	0.808715867	2.54E-37
TGCT	Cell metabolism gene	RARA	PRKD1	0.814628775	2.89E-38
TGCT	Cell metabolism gene	RARA	FMOD	0.823419795	9.85E-40
TGCT	Cell metabolism gene	RARA	SMARCD3	0.871711127	1.44E-49
TGCT	CGC	RARA	SPOP	0.842350687	3.44E-43
TGCT	Epifactor	RARA	PHC2	0.826601803	2.77E-40
TGCT	Epifactor	RARA	SPOP	0.842350687	3.44E-43
TGCT	Epifactor	RARA	SMARCD3	0.871711127	1.44E-49
TGCT	IUPHAR	RARA	F10	0.80680449	5.05E-37
TGCT	IUPHAR	RARA	DDAH2	0.807484289	3.96E-37
TGCT	IUPHAR	RARA	PDK2	0.808715867	2.54E-37
TGCT	IUPHAR	RARA	CPZ	0.812243961	7.01E-38
TGCT	IUPHAR	RARA	PRKD1	0.814628775	2.89E-38
TGCT	IUPHAR	RARA	IL11RA	0.815315843	2.23E-38
TGCT	IUPHAR	RARA	GHR	0.822980865	1.17E-39
TGCT	Kinase	RARA	PDK2	0.808715867	2.54E-37
TGCT	Kinase	RARA	PRKD1	0.814628775	2.89E-38
TGCT	TF	RARA	MEIS1	0.817263428	1.07E-38
TGCT	TF	RARA	ZBTB47	0.831578874	3.60E-41
TGCT	TSG	RARA	SPOP	0.842350687	3.44E-43
TGCT	TSG	RARA	NDRG2	0.842496657	3.22E-43

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
STAD	RARA	NCOR2	1.33883515600974	0.000133869703859091
LIHC	RARA	RXRB	-3.41865186450969	0.000201991820198738
LUSC	RARA	NCOA1	-1.9753943184964	0.000251881966259792
COAD	RARA	PML	-1.42773390537814	0.00028228759765625
STAD	RARA	NCOA1	-1.51648746101119	0.000394813584722933
STAD	RARA	RXRA	-2.26359423205792	0.00133262807503343
BRCA	RARA	NCOA3	1.28478455677002	0.00280496871821729
LUSC	RARA	NCOR1	-5.66830212737562	0.00339826502432084
CHOL	RARA	NCOR2	-6.56543632349982	0.00390625
CHOL	RARA	PML	-2.8303429721064	0.00390625
LUAD	RARA	NCOR2	-1.17884595496404	0.00627510264512955
STAD	RARA	PML	1.11096265710256	0.00879816571250558
LUAD	RARA	NCOA3	1.46493869373337	0.00907618026044385
BLCA	RARA	NCOA3	1.61306211717493	0.0108261108398438
LUSC	RARA	NCOA3	1.30984143728679	0.0112279623107666
THCA	RARA	NCOR1	-2.23607860124535	0.0143126941356972
KICH	RARA	NCOA3	-2.64018815864966	0.0147220492362976
CHOL	RARA	NCOA3	-2.60421993730511	0.01953125
BLCA	RARA	NCOR2	1.29630073916838	0.0229873657226562
LUAD	RARA	NCOR1	-4.5432022154879	0.0232982643302131
KICH	RARA	NCOA1	-2.41215844059557	0.0236499309539795
CHOL	RARA	RXRG	1.94121467442801	0.0390625
COAD	RARA	NCOA3	-2.47913041207233	0.0463311672210694
LUSC	RARA	RXRB	1.15588083356984	0.047424622014057
HNSC	RARA	NCOA2	-1.27957339544492	0.0497394773084908
HNSC	RARA	PML	1.9717462727518	1.07480439055508e-05
THCA	RARA	NCOA1	1.27209246249683	1.09911109570944e-05
KIRC	RARA	NCOA1	-1.69189826474347	2.99328726847022e-10
HNSC	RARA	NCOA3	1.89098442725377	3.84812503853028e-05
THCA	RARA	RXRA	-1.62554508939589	4.0132266032018e-09
KIRP	RARA	RXRG	1.22336088149455	4.20957803726197e-07
PRAD	RARA	NRIP1	1.9306455964487	5.16517456395129e-05
HNSC	RARA	RXRB	1.82489918701145	5.97184352955084e-05
THCA	RARA	RXRG	2.69954829028774	6.78994241272255e-11
COAD	RARA	NCOR1	-2.29343025369613	7.02440738677979e-05
KIRC	RARA	NCOR2	-1.71674966024156	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RARA

NRBF2, ZBTB16, MECR, RXRG, RXRB, NCOA6, GADD45G, GADD45A, Gadd45b, NRIP1, KAT2B, HDAC3, HDAC4, TDG, Nsd1, PML, TRIP4, KDM5A, RXRA, POU2F1, NCOR2, NR0B2, Nr0b2, BAG1, TADA3, NCOR1, NKX2-1, TRIM24, IRX4, SP1, NPAS2, CLOCK, ARNTL, NR2E3, CCND3, NCOA2, SRC, AJUBA, LIMD1, WTIP, SKI, HR, PIN1, SUV39H1, PSMC5, EP300, PARP1, MED6, TOP2B, SAP130, HNRNPU, RFC4, NPM1, MRTO4, SNRNP40, MED1, NCOA1, HMGA1, RUVBL1, RUNX1, SIAH1, RARA, HDAC2, NCOA3, CREBBP, LRIF1, KLF5, SMARCD3, ARID1A, SPI1, Pdia3, PRDX6, NR1H2, ITGB1BP2, MED25, MAPK6, FOXO1, MAPK1, TRIM32, PHF8, TNIP1, HACE1, SQSTM1, UBQLN1, ARID5A, UBE3A, PRAM1, FAS, PRAME, TBL1XR1, SUZ12, EZH2, USP7, TMEM54, MMS19, AKT1, FN1, WWOX, E2F1, MBD3, MTA2, CBX5, CEBPA, HDAC1, NSD1, TEKT4, SNW1, SIRT1, ACTN4, SRF, MDM2, ZNF131, RARG, RARB, TRIM25, FGFR1, Nr4a1, TRIB3, HSPA9, PIK3R1, PIK3CG, DSG4, FABP5, HSPA8, HSPB1, ATP8B2, PKP3, S100A3, SELENBP1, RPS27A, CEP83, H2AFY2, H1F0, HIST1H2AC, HIST2H2AB, H2AFV, HIST1H2BC, HIST3H3, RSL1D1, GTF2I, HNRNPK, KHDRBS1, LRRC15, PSPC1, RBM3, SNRNP70, HIST1H2AA, HNRNPA0, NR2C1, PPARG, BBS4, CCNDBP1, PLEKHF2, ALOX15B, ALX1, MCRS1, VCP, E7, TRIM37,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RARA	chr17	38487542	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RARA	chr17	38506186	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RARA	chr17	38508235	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RARA	chr17	38510572	C	T	single_nucleotide_variant	Uncertain_significance,_drug_response	Tretinoin_response\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RARA	chr17	38510573	G	A	single_nucleotide_variant	Likely_pathogenic	Inborn_genetic_diseases	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RARA	chr17	38510583	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RARA	chr17	38511509	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RARA	chr17	38512313	TCTCATCCAGGAAATGTTGGAGAACTCAGAGGGCCTGGACACTCTGAGCGGACAGCCGGGGGGTGGGGGGCGGGACGGGGGTGGCCTGGCCCCCCCGCCAGGCAGCTGTAGCCCCAGCCTCAGCCCCAGCTCCAACAGAAGCAGCCCGGCCACCCACTCCCCGTGA	T	Deletion	drug_response	Tretinoin_response	SO:0001578\|stop_lost	SO:0001578\|stop_lost
RARA	chr17	38512388	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RARA	KIRC	chr17	38506145	38506145	A	G	Missense_Mutation	p.Q146R	5
RARA	BLCA	chr17	38510626	38510626	C	T	Missense_Mutation	p.R294W	3
RARA	BLCA	chr17	38510642	38510642	A	G	Missense_Mutation	p.N299S	3
RARA	BRCA	chr17	38510603	38510603	T	C	Missense_Mutation	p.F286S	3
RARA	BRCA	chr17	38508182	38508184	AAG	-	In_Frame_Del	p.K167in_frame_del	3
RARA	STAD	chr17	38506076	38506076	C	T	Missense_Mutation	p.T123M	3
RARA	CESC	chr17	38508602	38508602	G	A	Missense_Mutation		3
RARA	HNSC	chr17	38487504	38487504	G	T	Missense_Mutation	p.G12W	2
RARA	BLCA	chr17	38512341	38512341	G	A	Missense_Mutation	p.E418K	2
RARA	STAD	chr17	38511645	38511645	T	C	Silent		2
RARA	LUAD	chr17	38510598	38510598	G	A	Missense_Mutation	p.M284I	2
RARA	STAD	chr17	38511645	38511645	T	C	Silent	p.I381I	2
RARA	SKCM	chr17	38498981	38498981	G	A	Missense_Mutation	p.G9S	2
RARA	STAD	chr17	38508602	38508602	G	C	Missense_Mutation	p.R217P	2
RARA	BLCA	chr17	38498963	38498963	G	C	Missense_Mutation	p.E3Q	2
RARA	SKCM	chr17	38487555	38487555	C	T	Missense_Mutation	p.P29S	2
RARA	UCEC	chr17	38506177	38506177	T	C	Missense_Mutation	p.S157P	2
RARA	BRCA	chr17	38508726	38508726	C	T	Silent	p.I258	2
RARA	HNSC	chr17	38508182	38508184	AAG	-	In_Frame_Del	p.K167del	2
RARA	STAD	chr17	38487554	38487554	C	-	Frame_Shift_Del	p.F28fs	2
RARA	ESCA	chr17	38508238	38508238	G	A	Silent		2
RARA	ESCA	chr17	38508238	38508238	G	A	Silent	p.P182P	2
RARA	LUAD	chr17	38487528	38487528	C	T	Missense_Mutation	p.P20S	2
RARA	CHOL	chr17	38510560	38510560	C	T	Missense_Mutation		2
RARA	SARC	chr17	38511541	38511541	C	T	Missense_Mutation	p.R347W	2
RARA	CHOL	chr17	38510560	38510560	C	T	Missense_Mutation	p.R272W	2
RARA	HNSC	chr17	38510721	38510721	G	C	Missense_Mutation		1
RARA	LUAD	chr17	38510602	38510603	TT	AC	Missense_Mutation	p.F286T	1
RARA	SKCM	chr17	38508593	38508593	C	T	Missense_Mutation	p.S214L	1
RARA	TGCT	chr17	38512394	38512394	T	G	Silent	p.G435G	1
RARA	KIRC	chr17	38510748	38510748	C	T	Silent	p.L334L	1
RARA	SKCM	chr17	38512373	38512373	G	C	Silent	p.G331G	1
RARA	COAD	chr17	38487587	38487587	C	T	Silent	p.G39G	1
RARA	LIHC	chr17	38504606	38504606	C	-	Frame_Shift_Del	p.P73fs	1
RARA	LUSC	chr17	38510742	38510742	C	T	Silent	p.I332I	1
RARA	STAD	chr17	38506076	38506076	C	T	Missense_Mutation		1
RARA	LUSC	chr17	38504711	38504711	T	A	Missense_Mutation	p.C108S	1
RARA	THCA	chr17	38508725	38508726	-	-	Frame_Shift_Ins		1
RARA	SKCM	chr17	38508593	38508593	C	T	Missense_Mutation	p.S117L	1
RARA	COAD	chr17	38498977	38498977	G	-	Frame_Shift_Del	p.V7fs	1
RARA	LIHC	chr17	38504615	38504615	C	-	Frame_Shift_Del	p.P76fs	1
RARA	HNSC	chr17	38511548	38511548	A	G	Missense_Mutation	p.D349G	1
RARA	MESO	chr17	38510722	38510722	A	T	Missense_Mutation		1
RARA	THCA	chr17	38508725	38508726	-	A	Frame_Shift_Ins	p.I258fs	1
RARA	KIRC	chr17	38508302	38508302	C	A	Missense_Mutation	p.Q204K	1
RARA	COAD	chr17	38504623	38504624	-	C	Frame_Shift_Ins	p.P78fs	1
RARA	SKCM	chr17	38508701	38508701	C	T	Missense_Mutation	p.T153I	1
RARA	HNSC	chr17	38512358	38512358	G	A	Silent	p.L423L	1
RARA	MESO	chr17	38504635	38504635	C	A	Silent		1
RARA	THCA	chr17	38508725	38508726	-	A	Frame_Shift_Ins	p.N258fs	1
RARA	BLCA	chr17	38499089	38499089	C	T	Missense_Mutation	p.R45W	1
RARA	KIRC	chr17	38508596	38508596	A	G	Missense_Mutation	p.E215G	1
RARA	COAD	chr17	38510560	38510560	C	T	Missense_Mutation	p.R175W	1
RARA	LUAD	chr17	38487490	38487490	C	T	Missense_Mutation	p.S7F	1
RARA	BLCA	chr17	38508601	38508601	C	T	Missense_Mutation		1
RARA	HNSC	chr17	38510721	38510721	G	C	Missense_Mutation	p.E325D	1
RARA	MESO	chr17	38510722	38510722	A	T	Missense_Mutation	p.T326S	1
RARA	THYM	chr17	38506115	38506115	C	T	Missense_Mutation		1
RARA	LIHC	chr17	38510578	38510578	A	G	Missense_Mutation		1
RARA	COAD	chr17	38510698	38510698	C	T	Missense_Mutation	p.P221S	1
RARA	LUAD	chr17	38487575	38487575	C	G	Silent	p.L35L	1
RARA	BLCA	chr17	38510626	38510626	C	T	Missense_Mutation		1
RARA	HNSC	chr17	38508322	38508322	G	A	Splice_Site	p.T210_splice	1
RARA	STAD	chr17	38499018	38499018	A	G	Missense_Mutation	p.Y21C	1
RARA	OV	chr17	38511642	38511642	G	C	Missense_Mutation	p.K380N	1
RARA	LIHC	chr17	38512266	38512266	G	A	Missense_Mutation		1
RARA	COAD	chr17	38511518	38511518	G	A	Missense_Mutation	p.R242H	1
RARA	LUAD	chr17	38506137	38506137	C	T	Silent	p.C143C	1
RARA	SKCM	chr17	38508718	38508718	G	A	Missense_Mutation	p.D159N	1
RARA	STAD	chr17	38499007	38499007	G	T	Silent	p.V17V	1
RARA	BLCA	chr17	38510642	38510642	A	G	Missense_Mutation		1
RARA	PRAD	chr17	38508633	38508633	G	T	Missense_Mutation	p.K227N	1
RARA	LIHC	chr17	38508601	38508601	C	A	Missense_Mutation	p.R217S	1
RARA	ESCA	chr17	38508238	38508238	G	A	Silent	p.P182	1
RARA	LUAD	chr17	38510602	38510602	T	A	Missense_Mutation	p.F286I	1
RARA	SKCM	chr17	38512295	38512295	C	T	Silent	p.I402I	1
RARA	BLCA	chr17	38499089	38499089	C	T	Missense_Mutation		1
RARA	HNSC	chr17	38508322	38508322	G	A	Silent	p.T210T	1
RARA	READ	chr17	38508267	38508267	G	A	Missense_Mutation	p.R95H	1
RARA	LIHC	chr17	38512266	38512266	G	A	Missense_Mutation	p.E393K	1
RARA	LUAD	chr17	38508718	38508718	G	T	Missense_Mutation	p.D256Y	1
RARA	SKCM	chr17	38512373	38512373	G	C	Silent	p.G428G	1
RARA	BLCA	chr17	38498963	38498963	G	C	Missense_Mutation		1
RARA	KICH	chr17	38512460	38512460	G	T	Silent		1
RARA	SARC	chr17	38508222	38508222	G	T	Missense_Mutation		1
RARA	LIHC	chr17	38510697	38510698	-	C	Frame_Shift_Ins	p.LP317fs	1
RARA	SKCM	chr17	38508718	38508718	G	A	Missense_Mutation	p.D256N	1
RARA	STAD	chr17	38506123	38506123	C	A	Missense_Mutation	p.R139S	1
RARA	BLCA	chr17	38508647	38508647	C	A	Missense_Mutation		1
RARA	KICH	chr17	38512460	38512460	G	T	Silent	p.P360P	1
RARA	SARC	chr17	38511541	38511541	C	T	Missense_Mutation		1
RARA	LIHC	chr17	38511612	38511612	C	-	Frame_Shift_Del	p.R370fs	1
RARA	HNSC	chr17	38487504	38487504	G	T	Missense_Mutation		1
RARA	LUAD	chr17	38510648	38510648	G	T	Missense_Mutation	p.G301V	1
RARA	SKCM	chr17	38508701	38508701	C	T	Missense_Mutation	p.T250I	1
RARA	STAD	chr17	38510653	38510653	G	A	Missense_Mutation	p.G303S	1
RARA	BLCA	chr17	38508601	38508601	C	T	Missense_Mutation	p.R217C	1
RARA	KICH	chr17	38512460	38512460	G	T	Silent	p.P457P	1
RARA	LIHC	chr17	38512331	38512331	G	-	Frame_Shift_Del	p.L414fs	1

Copy number variation (CNV) of RARA
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RARA
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
100461	STAD	TCGA-BR-8483	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
100461	STAD	TCGA-BR-8483-01A	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
100461	STAD	TCGA-BR-8680	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
100461	READ	TCGA-AG-3581	ATP6V0A1	chr17	40642655	+	RARA	chr17	38487108	+
100461	READ	TCGA-AG-3581	ATP6V0A1	chr17	40642655	+	RARA	chr17	38487109	+
100461	acute myeloid leukemia	HM597846	BCOR	chrX	39937182		RARA	chr17	38504566
100461	.	.	BCOR	chrX	39914766	-	RARA	chr17	39914766	+
100461	N/A	HM597846	BCOR	chrX	39914621	-	RARA	chr17	38504566	+
100461	Non-Cancer	ERR315486	CXCR4	chr2	136875616	-	RARA	chr17	38504568	+
100461	.	.	FIP1L1	chr4	54310214	+	RARA	chr17	54310214	+
100461	.	.	GTF2I	chr7	74114935	+	RARA	chr17	74114935	+
100461	N/A	KP100665	GTF2I	chr7	74114964	+	RARA	chr17	38504565	+
100461	N/A	BE794377	H2AFV	chr7	44880525	-	RARA	chr17	38506148	+
100461	COAD	TCGA-AY-4070-01A	IKZF3	chr17	37944511	-	RARA	chr17	38487109	+
100461	.	.	IRF2BP2	chr1	234743598	-	RARA	chr17	234743598	+
100461	.	.	IRF2BP2	chr1	234745271	-	RARA	chr17	234745271	+
100461	STAD	TCGA-FP-8210-01A	JHDM1D	chr7	139876544	-	RARA	chr17	38504568	+
100461	OV	TCGA-29-2428	MUC16	chr19	9045563	-	RARA	chr17	38487108	+
100461	OV	TCGA-29-2428-01A	MUC16	chr19	9045564	-	RARA	chr17	38487109	+
100461	CESC	TCGA-VS-A8EJ-01A	MYO18A	chr17	27507331	-	RARA	chr17	38504568	+
100461	.	.	NABP1	chr2	192548955	+	RARA	chr17	192548955	+
100461	acute non lymphocytic leukemia	U41743	NPM1	chr5	170818803		RARA	chr17	38504565
100461	.	.	NPM1	chr5	170818803	+	RARA	chr17	38504567	+
100461	N/A	U41743	NPM1	chr5	170818803	+	RARA	chr17	38504565	+
100461	acute promyelocytic leukemia	AF012304	NUMA1	chr11	71717270		RARA	chr17	38504544
100461	.	.	NUMA1	chr11	71717080	-	RARA	chr17	38504567	+
100461	N/A	AF012304	NUMA1	chr11	71717081	-	RARA	chr17	38504544	+
100461	acute promyelocytic leukemia	AB067754	PML	chr15	74325609		RARA	chr17	38503513
100461	LAML	TCGA-AB-2803-03A	PML	chr15	74325755	+	RARA	chr17	38504568	+
100461	LAML	TCGA-AB-2803-03A	PML	chr15	74326174	+	RARA	chr17	38494414	+
100461	LAML	TCGA-AB-2823-03A	PML	chr15	74315748	+	RARA	chr17	38499047	+
100461	LAML	TCGA-AB-2823-03A	PML	chr15	74315748	+	RARA	chr17	38504567	+
100461	LAML	TCGA-AB-2823-03A	PML	chr15	74315749	+	RARA	chr17	38504568	+
100461	LAML	TCGA-AB-2841-03B	PML	chr15	74317268	+	RARA	chr17	38504568	+
100461	LAML	TCGA-AB-2862	PML	chr15	74325755	+	RARA	chr17	38504567	+
100461	LAML	TCGA-AB-2862-03A	PML	chr15	74325754	+	RARA	chr17	38504567	+
100461	LAML	TCGA-AB-2862-03A	PML	chr15	74325762	+	RARA	chr17	38504567	+
100461	LAML	TCGA-AB-2862-03A	PML	chr15	74326513	+	RARA	chr17	38502175	+
100461	LAML	TCGA-AB-2872-03A	PML	chr15	74325947	+	RARA	chr17	38492306	+
100461	LAML	TCGA-AB-2897-03A	PML	chr15	74317267	+	RARA	chr17	38504567	+
100461	LAML	TCGA-AB-2897-03A	PML	chr15	74325861	+	RARA	chr17	38495607	+
100461	LAML	TCGA-AB-2982-03B	PML	chr15	74326442	+	RARA	chr17	38496872	+
100461	LAML	TCGA-AB-2994-03A	PML	chr15	74326459	+	RARA	chr17	38498831	+
100461	LAML	TCGA-AB-2999_61YB3AAXX_4	PML	chr15	74325056	+	RARA	chr17	38504568	+
100461	LAML	TCGA-AB-3001-03A	PML	chr15	74315748	+	RARA	chr17	38499005	+
100461	LAML	TCGA-AB-3001-03A	PML	chr15	74315749	+	RARA	chr17	38499006	+
100461	LAML	TCGA-AB-3007	PML	chr15	74315749	+	RARA	chr17	38504567	+
100461	.	.	PML	chr15	74326146	+	RARA	chr17	38504568	+
100461	.	.	PML	chr15	74326417	+	RARA	chr17	38504568	+
100461	.	.	PML	chr15	74326871	+	RARA	chr17	38504567	+
100461	.	.	PML	chr15	74326146	+	RARA	chr17	38504568	+
100461	N/A	AB067754	PML	chr15	74325609	+	RARA	chr17	38503513	+
100461	N/A	AJ417079	PML	chr15	74325616	+	RARA	chr17	38499056	+
100461	N/A	EF535849	PML	chr15	74317268	+	RARA	chr17	38504567	+
100461	N/A	M61110	PML	chr15	74326417	+	RARA	chr17	38504195	+
100461	N/A	M73779	PML	chr15	74315749	+	RARA	chr17	38504566	+
100461	N/A	S50916	PML	chr15	74325755	+	RARA	chr17	38504566	+
100461	N/A	S57796	PML	chr15	74326821	+	RARA	chr17	38503921	+
100461	N/A	S76373	PML	chr15	74326146	+	RARA	chr17	38504542	+
100461	N/A	S76375	PML	chr15	74326245	+	RARA	chr17	38503275	+
100461	N/A	S76382	PML	chr15	74326354	+	RARA	chr17	38504168	+
100461	N/A	S76389	PML	chr15	74326417	+	RARA	chr17	38502790	+
100461	N/A	S76402	PML	chr15	74326633	+	RARA	chr17	38502991	+
100461	acute promyelocytic leukemia	EF428110	PRKAR1A	chr17	66518996		RARA	chr17	38504566
100461	.	.	PRKAR1A	chr17	64023312	+	RARA	chr17	35758091	+
100461	.	.	PRKAR1A	chr17	64030591	+	RARA	chr17	35758091	+
100461	N/A	EF428110	PRKAR1A	chr17	66518996	+	RARA	chr17	38504566	+
100461	N/A	EF428111	PRKAR1A	chr17	66511717	+	RARA	chr17	38504566	+
98429	BRCA	TCGA-E9-A22D-01A	RARA	chr17	38474699	+	ANKFN1	chr17	54367287	-
102079	N/A	BU154393	RARA	chr17	38487646	+	BRD4	chr19	15367035	-
100106	BRCA	TCGA-AN-A046	RARA	chr17	38487648	+	C16orf45	chr16	15609161	+
102776	BRCA	TCGA-A8-A0A7-01A	RARA	chr17	38474700	+	CA10	chr17	50149753	-
99263	BRCA	TCGA-AR-A254-01A	RARA	chr17	38487648	+	CDC6	chr17	38450202	+
99263	BRCA	TCGA-AR-A254-01A	RARA	chr17	38499119	+	CDC6	chr17	38450202	+
99263	LUAD	TCGA-95-7948-01A	RARA	chr17	38465538	+	CDC6	chr17	38457080	+
99264	BRCA	TCGA-A2-A04W	RARA	chr17	38465538	+	CDK12	chr17	37646809	+
99264	BRCA	TCGA-A2-A04W	RARA	chr17	38474700	+	CDK12	chr17	37646809	+
99264	BRCA	TCGA-A2-A04W-01A	RARA	chr17	38465538	+	CDK12	chr17	37646810	+
99264	BRCA	TCGA-A2-A04W-01A	RARA	chr17	38474700	+	CDK12	chr17	37646810	+
99264	BRCA	TCGA-AC-A2FB-01A	RARA	chr17	38474700	+	CDK12	chr17	37700502	+
99264	OV	TCGA-3P-A9WA	RARA	chr17	38504716	+	CDK12	chr17	37686856	+
99264	OV	TCGA-3P-A9WA	RARA	chr17	38504716	+	CDK12	chr17	37686883	+
99264	OV	TCGA-3P-A9WA-01A	RARA	chr17	38504716	+	CDK12	chr17	37686857	+
99264	OV	TCGA-3P-A9WA-01A	RARA	chr17	38504716	+	CDK12	chr17	37686884	+
99264	OV	TCGA-3P-A9WA-01A	RARA	chr17	38504716	+	CDK12	chr17	37700502	+
102358	UCEC	TCGA-2E-A9G8	RARA	chr17	38465538	+	CERS4	chr19	8315960	+
102358	UCEC	TCGA-2E-A9G8	RARA	chr17	38474700	+	CERS4	chr19	8315928	+
102358	UCEC	TCGA-2E-A9G8	RARA	chr17	38474700	+	CERS4	chr19	8319383	+
102358	UCEC	TCGA-2E-A9G8-01A	RARA	chr17	38474700	+	CERS4	chr19	8315960	+
72327	BRCA	TCGA-EW-A6S9-01A	RARA	chr17	38487648	+	COL10A1	chr6	116446670	-
99033	STAD	TCGA-RD-A7BT	RARA	chr17	38487648	+	DAZAP1	chr19	1417498	+
82052	BRCA	TCGA-AO-A12D-01A	RARA	chr17	38508759	-	HOXB3	chr17	46632980	-
82052	BRCA	TCGA-AO-A12D-01A	RARA	chr17	38510568	+	HOXB3	chr17	46643200	+
96400	BRCA	TCGA-B6-A1KN-01A	RARA	chr17	38487648	+	IGFBP4	chr17	38609237	+
102716	STAD	TCGA-CG-5724-01A	RARA	chr17	38487648	+	IMMP2L	chr7	111201979	-
99272	STAD	TCGA-EQ-8122	RARA	chr17	38465538	+	JUP	chr17	39923832	-
99272	STAD	TCGA-RD-A7BT	RARA	chr17	38487648	+	JUP	chr17	39928114	-
72327	STAD	TCGA-RD-A7BT	RARA	chr17	38487648	+	LEPREL4	chr17	39967536	-
72327	BRCA	TCGA-C8-A8HP-01A	RARA	chr17	38465538	+	LGALS16	chr19	40148468	+
72327	BRCA	TCGA-C8-A8HP-01A	RARA	chr17	38465538	-	LGALS16	chr19	40148523	+
100815	UCEC	TCGA-AJ-A3QS-01A	RARA	chr17	38474700	+	LTBP1	chr2	33447147	+
100822	STAD	TCGA-RD-A7BT-01A	RARA	chr17	38487648	+	LYRM9	chr17	26207392	-
100822	STAD	TCGA-RD-A7BT-01A	RARA	chr17	38487648	+	LYRM9	chr17	26209738	-
100822	STAD	TCGA-RD-A7BT-01A	RARA	chr17	38499119	+	LYRM9	chr17	26209738	-
99278	BRCA	TCGA-AR-A254	RARA	chr17	38487648	+	MSL1	chr17	38282435	+
99278	BRCA	TCGA-AR-A254-01A	RARA	chr17	38487647	+	MSL1	chr17	38282435	+
99278	BRCA	TCGA-AR-A254-01A	RARA	chr17	38487648	+	MSL1	chr17	38282436	+
100670	BRCA	TCGA-A8-A09I-01A	RARA	chr17	38487647	+	MYO1D	chr17	31107801	-
100670	BRCA	TCGA-A8-A09I-01A	RARA	chr17	38487648	+	MYO1D	chr17	31107802	-
100670	BRCA	TCGA-A8-A09I-01A	RARA	chr17	38487648	+	MYO1D	chr17	31113810	-
90848	BRCA	TCGA-A1-A0SM-01A	RARA	chr17	38487648	+	NARS2	chr11	78282489	-
97362	BRCA	TCGA-A2-A0D4-01A	RARA	chr17	38474700	+	PCTP	chr17	53848467	+
97362	BRCA	TCGA-AN-A0FV	RARA	chr17	38465538	+	PCTP	chr17	53848466	+
97362	BRCA	TCGA-AN-A0FV	RARA	chr17	38474700	+	PCTP	chr17	53848466	+
97362	BRCA	TCGA-AN-A0FV-01A	RARA	chr17	38465537	+	PCTP	chr17	53848466	+
97362	BRCA	TCGA-AN-A0FV-01A	RARA	chr17	38465538	+	PCTP	chr17	53848467	+
97362	BRCA	TCGA-AN-A0FV-01A	RARA	chr17	38474699	+	PCTP	chr17	53848466	+
99077	BRCA	TCGA-A8-A08B-01A	RARA	chr17	38474700	+	PGAP3	chr17	37842272	-
99077	BRCA	TCGA-A8-A08B-01A	RARA	chr17	38474700	-	PGAP3	chr17	37830932	-
97894	N/A	XX000008	RARA	chr17	38465538	+	PKIA	chr8	79485043	+
86231	UCEC	TCGA-A5-A7WK-01A	RARA	chr17	38487648	+	PLEKHA6	chr1	204243937	-
72327	LAML	TCGA-AB-2840_61GAFAAXX_2	RARA	chr17	38487648	+	PML	chr15	74317198	+
72327	LAML	TCGA-AB-2872_70417AAXX_3	RARA	chr17	38487648	+	PML	chr15	74326819	+
72327	LAML	TCGA-AB-2994	RARA	chr17	38487648	+	PML	chr15	74326818	+
72327	LAML	TCGA-AB-2994_700F8AAXX_2	RARA	chr17	38498669	+	PML	chr15	74326819	+
72327	LAML	TCGA-AB-2998_700D6AAXX_3	RARA	chr17	38487648	+	PML	chr15	74325497	+
72327	LAML	TCGA-AB-2998_700HWAAXX_3	RARA	chr17	38487648	+	PML	chr15	74324913	+
72327	LAML	TCGA-AB-3001	RARA	chr17	38487648	+	PML	chr15	74317197	+
72327	LAML	TCGA-AB-3012	RARA	chr17	38499119	+	PML	chr15	74326818	+
72327	LAML	TCGA-AB-3012_61LMEAAXX_6	RARA	chr17	38499119	+	PML	chr15	74326819	+
72327	N/A	M82827	RARA	chr17	38487648	+	PML	chr15	74317198	+
72327	N/A	S57797	RARA	chr17	38503920	+	PML	chr15	74326822	+
72327	N/A	S76370	RARA	chr17	38504435	+	PML	chr15	74325745	+
72327	N/A	S76372	RARA	chr17	38503830	+	PML	chr15	74325747	+
72327	N/A	S76379	RARA	chr17	38503278	+	PML	chr15	74326239	+
72327	N/A	S76387	RARA	chr17	38504165	+	PML	chr15	74326351	+
72327	N/A	S76395	RARA	chr17	38502793	+	PML	chr15	74326423	+
72327	N/A	S76399	RARA	chr17	38503054	+	PML	chr15	74326518	+
72327	N/A	S76405	RARA	chr17	38502990	+	PML	chr15	74326627	+
92589	BRCA	TCGA-A2-A0D1-01A	RARA	chr17	38487648	+	POLDIP2	chr17	26681611	-
103131	STAD	TCGA-D7-8573	RARA	chr17	38474700	+	PPP1R1B	chr17	37785422	+
103131	STAD	TCGA-D7-8573-01A	RARA	chr17	38474700	+	PPP1R1B	chr17	37785423	+
98206	BRCA	TCGA-A2-A0YG	RARA	chr17	38465538	+	PRR11	chr17	57247108	+
98206	BRCA	TCGA-A2-A0YG	RARA	chr17	38474700	+	PRR11	chr17	57247108	+
98206	BRCA	TCGA-A2-A0YG	RARA	chr17	38474700	+	PRR11	chr17	57262414	+
98206	BRCA	TCGA-A2-A0YG-01A	RARA	chr17	38465537	+	PRR11	chr17	57247108	+
98206	BRCA	TCGA-A2-A0YG-01A	RARA	chr17	38465538	+	PRR11	chr17	57247109	+
98206	BRCA	TCGA-A2-A0YG-01A	RARA	chr17	38474699	+	PRR11	chr17	57240959	+
98206	BRCA	TCGA-A2-A0YG-01A	RARA	chr17	38474699	+	PRR11	chr17	57247108	+
98206	BRCA	TCGA-A2-A0YG-01A	RARA	chr17	38474699	+	PRR11	chr17	57262414	+
98206	BRCA	TCGA-A2-A0YG-01A	RARA	chr17	38474700	+	PRR11	chr17	57247109	+
99282	BRCA	TCGA-EW-A1J3	RARA	chr17	38487648	+	PSMD3	chr17	38151206	+
99282	BRCA	TCGA-EW-A1J3	RARA	chr17	38499119	+	PSMD3	chr17	38151206	+
99282	BRCA	TCGA-EW-A1J3-01A	RARA	chr17	38487647	+	PSMD3	chr17	38151206	+
99282	BRCA	TCGA-EW-A1J3-01A	RARA	chr17	38487648	+	PSMD3	chr17	38151207	+
72327	BRCA	TCGA-AN-A041-01A	RARA	chr17	38512898	+	PSME3	chr17	40989666	+
100461	N/A	X06538	RARA	chr17	38474639	-	RARA	chr17	38487504	+
72327	BRCA	TCGA-BH-A0DD-01A	RARA	chr17	38474700	-	RP11-1407O15.2	chr17	36359042	-
102865	BRCA	TCGA-BH-A202-01A	RARA	chr17	38487648	+	SEPT9	chr17	75483506	+
94101	BRCA	TCGA-A2-A0YG-01A	RARA	chr17	38465537	+	SKA2	chr17	57232183	+
94101	BRCA	TCGA-A2-A0YG-01A	RARA	chr17	38474699	+	SKA2	chr17	57232183	+
92287	BRCA	TCGA-B6-A0IN	RARA	chr17	38487648	+	SKAP1	chr17	46211178	-
92287	BRCA	TCGA-B6-A0IN	RARA	chr17	38499119	+	SKAP1	chr17	46214699	-
92287	BRCA	TCGA-B6-A0IN-01A	RARA	chr17	38487647	+	SKAP1	chr17	46211177	-
92287	BRCA	TCGA-B6-A0IN-01A	RARA	chr17	38487647	+	SKAP1	chr17	46214698	-
92287	BRCA	TCGA-B6-A0IN-01A	RARA	chr17	38487648	+	SKAP1	chr17	46214699	-
91508	UCS	TCGA-N8-A4PQ-01A	RARA	chr17	38508759	+	SLC9A3R1	chr17	72758151	+
72327	LUAD	TCGA-55-1592-01A	RARA	chr17	38474700	+	STAC2	chr17	37374426	-
96866	BRCA	TCGA-EW-A1J3-01A	RARA	chr17	38465537	+	STAT3	chr17	40500537	-
96866	BRCA	TCGA-EW-A1J3-01A	RARA	chr17	38465537	+	STAT3	chr17	40500556	-
96866	BRCA	TCGA-EW-A1J3-01A	RARA	chr17	38465538	+	STAT3	chr17	40500538	-
96866	BRCA	TCGA-EW-A1J3-01A	RARA	chr17	38465538	-	STAT3	chr17	40500557	-
72327	BRCA	TCGA-BH-A0DD	RARA	chr17	38474700	+	TBC1D3B	chr17	34502411	-
85105	BRCA	TCGA-BH-A0DD	RARA	chr17	38474700	+	TBC1D3F	chr17	36285543	+
85105	BRCA	TCGA-BH-A1EV	RARA	chr17	38508759	+	TBC1D3F	chr17	36289993	+
88962	BRCA	TCGA-BH-A1EV-01A	RARA	chr17	38508759	+	TBC1D3H	chr17	34751022	-
99290	BRCA	TCGA-GM-A2DA-01A	RARA	chr17	38487648	+	THRA	chr17	38240088	+
72327	BRCA	TCGA-EW-A6S9-01A	RARA	chr17	38487647	+	TSPYL4	chr6	116571580	-
72327	BRCA	TCGA-EW-A6S9-01A	RARA	chr17	38487648	+	TSPYL4	chr6	116571581	-
99295	BRCA	TCGA-BH-A202	RARA	chr17	38487648	+	WIPF2	chr17	38430041	+
99295	BRCA	TCGA-BH-A202-01A	RARA	chr17	38487647	+	WIPF2	chr17	38430041	+
99295	BRCA	TCGA-BH-A202-01A	RARA	chr17	38487648	+	WIPF2	chr17	38430042	+
99295	STAD	TCGA-VQ-A8PH	RARA	chr17	38474700	+	WIPF2	chr17	38412642	+
99295	STAD	TCGA-VQ-A8PH	RARA	chr17	38487648	+	WIPF2	chr17	38412642	+
99295	STAD	TCGA-VQ-A8PH-01A	RARA	chr17	38474700	+	WIPF2	chr17	38412643	+
99295	STAD	TCGA-VQ-A8PH-01A	RARA	chr17	38487648	+	WIPF2	chr17	38412643	+
103137	BRCA	TCGA-AR-A0TX	RARA	chr17	38474700	+	ZNF595	chr4	59322	+
103137	BRCA	TCGA-AR-A0TX	RARA	chr17	38487648	+	ZNF595	chr4	59322	+
103137	BRCA	TCGA-AR-A0TX-01A	RARA	chr17	38487648	+	ZNF595	chr4	59323	+
95990	BRCA	TCGA-AR-A0TX-01A	RARA	chr17	38487647	+	ZNF718	chr4	59322	+
99298	BRCA	TCGA-B6-A0I1-01A	RARA	chr17	38487648	+	ZPBP2	chr17	38031507	+
100461	COAD	TCGA-CM-6167-01A	RNF43	chr17	56492687	-	RARA	chr17	38487109	+
100461	PRAD	TCGA-HC-7750	RPL3	chr22	39711375	-	RARA	chr17	38498827	+
100461	BRCA	TCGA-BH-A1EV-01A	SGCD	chr5	156022061	+	RARA	chr17	38504568	+
100461	READ	TCGA-AH-6643	SMARCE1	chr17	38792182	-	RARA	chr17	38511514	+
100461	READ	TCGA-AH-6643-01A	SMARCE1	chr17	38792183	-	RARA	chr17	38511515	+
100461	BRCA	TCGA-LD-A9QF	SPOP	chr17	47755294	-	RARA	chr17	38487108	+
100461	BRCA	TCGA-LD-A9QF-01A	SPOP	chr17	47755295	-	RARA	chr17	38487109	+
100461	.	.	STAT5B	chr17	40362188	-	RARA	chr17	38504567	+
100461	.	.	STAT5B	chr17	40362319	-	RARA	chr17	40362319	+
100461	GBM	TCGA-06-0141-01A	TAOK1	chr17	27718042	+	RARA	chr17	38504568	+
100461	.	.	TBL1XR1	chr3	176769514	-	RARA	chr17	176769514	+
100461	N/A	KF589333	TBL1XR1	chr3	176769292	-	RARA	chr17	38504568	+
100461	BRCA	TCGA-EW-A1IW-01A	TPCN2	chr11	68830458	+	RARA	chr17	38487109	+
100461	ESCA	TCGA-L5-A43C	WDR59	chr16	74982416	-	RARA	chr17	38487108	+
100463	PCPG	TCGA-WB-A81E-01A	ZBTB4	chr17	7365738	-	RARA	chr17	38487109	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
BRCA	RARA	0.000205996189691899	0.0056
LIHC	RARA	0.00240149430440428	0.062
LUAD	RARA	0.0118532566904607	0.3
KIRP	RARA	0.0185514680390074	0.45
LGG	RARA	0.0305646448193272	0.7
KIRC	RARA	0.0314248658348089	0.7
LUSC	RARA	0.0345763583867024	0.73
TGCT	RARA	9.33693709708224e-05	0.0026

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
STAD	RARA	0.00240444296036484	0.075
LUSC	RARA	0.00140739475261782	0.045
KIRP	RARA	0.0240629849609032	0.7
BRCA	RARA	3.22729413606381e-05	0.0011
OV	RARA	0.00553808612150814	0.17
UCEC	RARA	0.0380100868732719	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
P10276	DB00210	Adapalene		Small molecule	Approved
P10276	DB00459	Acitretin	Agonist	Small molecule	Approved
P10276	DB00523	Alitretinoin	Agonist	Small molecule	Approved\|Investigational
P10276	DB00755	Tretinoin		Small molecule	Approved\|Investigational\|Nutraceutical
P10276	DB00799	Tazarotene	Agonist	Small molecule	Approved\|Investigational
P10276	DB00926	Etretinate	Agonist	Small molecule	Withdrawn
P10276	DB00982	Isotretinoin	Other/unknown	Small molecule	Approved
P10276	DB04942	Tamibarotene	Agonist	Small molecule	Investigational
P10276	DB05785	LGD-1550		Small molecule	Investigational
P10276	DB12808	Trifarotene	Agonist	Small molecule	Approved\|Investigational
P10276	DB00210	Adapalene
P10276	DB00459	Acitretin	Agonist
P10276	DB00523	Alitretinoin	Agonist
P10276	DB00755	Tretinoin
P10276	DB00799	Tazarotene	Agonist
P10276	DB00926	Etretinate	Agonist
P10276	DB00982	Isotretinoin	Other/unknown
P10276	DB04942	Tamibarotene	Agonist
P10276	DB05785	LGD-1550
P10276	DB12808	Trifarotene	Agonist

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0023487	Acute Promyelocytic Leukemia	24	CTD_human;ORPHANET
C0036341	Schizophrenia	3	PSYGENET
C0006142	Malignant neoplasm of breast	1	CTD_human
C0009363	Congenital ocular coloboma (disorder)	1	GENOMICS_ENGLAND
C0010701	Phyllodes Tumor	1	CTD_human
C0149940	Sciatic Neuropathy	1	CTD_human
C0154748	Lesion of Sciatic Nerve	1	CTD_human
C0206650	Fibroadenoma	1	CTD_human
C0242013	Sciatic Neuritis	1	CTD_human
C0600066	Malignant Cystosarcoma Phyllodes	1	CTD_human
C0678222	Breast Carcinoma	1	CTD_human
C0751924	Neuralgia-Neuritis, Sciatic Nerve	1	CTD_human
C0751925	Sciatic Nerve Palsy	1	CTD_human
C0877578	Treatment related secondary malignancy	1	CTD_human
C1257931	Mammary Neoplasms, Human	1	CTD_human
C2239176	Liver carcinoma	1	CTD_human
C4704874	Mammary Carcinoma, Human	1	CTD_human