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Translation Factor: MRPS35 (NCBI Gene ID:60488) |
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Gene Summary |
Gene Information | Gene Name: MRPS35 | Gene ID: 60488 | Gene Symbol | MRPS35 | Gene ID | 60488 |
Gene Name | mitochondrial ribosomal protein S35 | |
Synonyms | HDCMD11P|MDS023|MRP-S28|MRPS28 | |
Cytomap | 12p11.22 | |
Type of Gene | protein-coding | |
Description | 28S ribosomal protein S35, mitochondrial28S ribosomal protein S28, mitochondrialMRP-S35S28mtS35mtmitochondrial ribosomal protein S28mitochondrial small ribosomal subunit protein mS35 | |
Modification date | 20200313 | |
UniProtAcc | . |
Child GO biological process term(s) under GO:0006412 |
GO ID | GO term |
Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Inferred gene age of translation factor. |
Gene | Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25 |
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We searched PubMed using 'MRPS35[title] AND translation [title] AND human.' |
Gene | Title | PMID |
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Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. For more annotations, please visit our ExonSkipDB. |
Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ENST | Exon skip start (DNA) | Exon Skip end (DNA) | ORF |
Exon skipping position in the amino acid sequence. |
ENST | Exon skip start (DNA) | Exon Skip end (DNA) | Len(transcript seq) | Exon skip start (mRNA) | Exon Skip end (mRNA) | Len(amino acid seq) | Exon skip start (AA) | Exon Skip end (AA) |
Potentially (partially) lost protein functional features of UniProt. |
UniProtAcc | Exon skip start (AA) | Exon Skip end (AA) | Function feature start (AA) | Function feature end (AA) | Functional feature type | Functional feature desc. |
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Gene expression level across TCGA pancancer |
Gene expression level across GTEx pantissue |
Expression level of gene isoforms across TCGA pancancer |
Expression level of gene isoforms across GTEx pantissue |
Cancer(tissue) type-specific expression level of Translation factor using z-score distriution |
Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples) |
Cancer type | Translation factor | FC | adj.pval |
KICH | MRPS35 | 1.14233082673341 | 1.96695327758789e-06 |
KIRC | MRPS35 | -2.33452405563859 | 3.58581186640388e-10 |
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Translation factor expression regulation through miRNA binding |
Cancer type | Gene | miRNA | TargetScan binding score (Context++ score percentile) | Coefficient | Pvalue |
Translation factor expression regulation through methylation in the promoter of Translation factor |
Cancer type | Gene | methyl group b | methyl group a | DEG pval | avg methyl in b | avg methyl in a | avg exp in b | avg exp in a |
Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation) |
Cancer type | Gene | methyl group b | methyl group a | DEG pval | avg methyl in b | avg methyl in a | avg exp in b | avg exp in a |
Translation factor expression regulation through copy number variation of Translation factor |
Cancer type | Gene | Coefficient | Pvalue |
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Strongly correlated genes belong to cellular important gene groups with MRPS35 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green) |
Cancer type | Gene group | Translation factor | Correlated gene | Coefficient | Pvalue |
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Protein 3D structure Visit iCn3D. |
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Protein-protein interaction networks * Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P)) |
Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P)) |
* Edge colors based on TCGA cancer types. |
* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P)) |
Cancer type | Translation factor | Interacting protein coding gene | FC | adj.pval |
Protein-protein interactors with this translation factor (BIOGRID-3.4.160) |
PPI interactors with MRPS35 |
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Clinically associated variants from ClinVar. |
Gene | Chr | Position | RefSeq | VarSeq | RefSeeq | VarType | Pathogenic | Disease | VarInfo |
nsSNVs with sample frequency (size of circle) from TCGA 33 cancers. |
SNVs and Indels |
Gene | Cancer type | Chromosome | Start | End | RefSeeq | MutSeq | Mutation type | AAchange | # samples |
Copy number variation (CNV) of MRPS35 * Click on the image to open the original image in a new window. |
Fusion gene breakpoints (product of the structural variants (SVs)) across MRPS35 * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion genes with this translation factor from FusionGDB2.0. |
FusionGDB2 ID | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
96980 | STAD | TCGA-CD-8524 | B3GALTL | chr13 | 31789237 | + | MRPS35 | chr12 | 27872740 | + |
96980 | STAD | TCGA-CD-8524-01A | B3GALTL | chr13 | 31789237 | + | MRPS35 | chr12 | 27872741 | + |
96980 | BRCA | TCGA-D8-A1XW | BCAT1 | chr12 | 25031463 | - | MRPS35 | chr12 | 27908113 | + |
96980 | BRCA | TCGA-C8-A1HJ-01A | CCDC91 | chr12 | 28637098 | + | MRPS35 | chr12 | 27890472 | + |
96980 | PRAD | TCGA-XK-AAJ3 | FGD4 | chr12 | 32552893 | + | MRPS35 | chr12 | 27908114 | + |
96980 | PRAD | TCGA-XK-AAJ3-01A | FGD4 | chr12 | 32552893 | + | MRPS35 | chr12 | 27867713 | + |
96980 | STAD | TCGA-CG-5721-01A | FGFR1OP2 | chr12 | 27091643 | + | MRPS35 | chr12 | 27888380 | + |
96980 | BRCA | TCGA-A7-A2KD | HSPA14 | chr10 | 14882156 | + | MRPS35 | chr12 | 27888379 | + |
96980 | BRCA | TCGA-A7-A2KD-01A | HSPA14 | chr10 | 14882156 | + | MRPS35 | chr12 | 27888380 | + |
96980 | OV | TCGA-25-1329-01A | ITPR2 | chr12 | 26774056 | - | MRPS35 | chr12 | 27888380 | + |
96980 | BLCA | TCGA-G2-A3IE-01A | KLHL42 | chr12 | 27934135 | + | MRPS35 | chr12 | 27908114 | + |
89171 | LUAD | TCGA-50-5066-01A | MRPS35 | chr12 | 27890541 | + | CCDC91 | chr12 | 28636985 | + |
78887 | N/A | BE840739 | MRPS35 | chr12 | 27908835 | - | CSTA | chr3 | 122060371 | + |
55215 | STAD | TCGA-IP-7968-01A | MRPS35 | chr12 | 27869391 | + | LYRM5 | chr12 | 25356854 | + |
55215 | STAD | TCGA-IP-7968-01A | MRPS35 | chr12 | 27869391 | + | LYRM5 | chr12 | 25357025 | + |
94058 | N/A | BM151173 | MRPS35 | chr12 | 27867128 | - | MND1 | chr4 | 154303866 | + |
93302 | N/A | N22254 | MRPS35 | chr12 | 27870261 | + | MYD88 | chr3 | 38184513 | - |
92615 | BRCA | TCGA-BH-A18T | MRPS35 | chr12 | 27877119 | + | PPFIBP1 | chr12 | 27829360 | + |
92615 | BRCA | TCGA-BH-A18T-01A | MRPS35 | chr12 | 27877119 | + | PPFIBP1 | chr12 | 27829361 | + |
92615 | LUSC | TCGA-18-3421-01A | MRPS35 | chr12 | 27890541 | + | PPFIBP1 | chr12 | 27840318 | + |
92615 | STAD | TCGA-IP-7968-01A | MRPS35 | chr12 | 27863888 | + | PPFIBP1 | chr12 | 27731085 | + |
87543 | KIRC | TCGA-CJ-4893-01A | MRPS35 | chr12 | 27877119 | + | SMCO2 | chr12 | 27627719 | + |
86189 | PCPG | TCGA-QR-A6H4-01A | MRPS35 | chr12 | 27877119 | + | ST6GALNAC5 | chr1 | 77509889 | + |
96980 | BLCA | TCGA-XF-AAMW-01A | P2RY6 | chr11 | 72975694 | + | MRPS35 | chr12 | 27890472 | + |
96980 | PAAD | TCGA-IB-A6UF | PKP2 | chr12 | 32949043 | - | MRPS35 | chr12 | 27890472 | + |
96980 | PAAD | TCGA-IB-A6UF-01A | PKP2 | chr12 | 32949043 | - | MRPS35 | chr12 | 27888380 | + |
96980 | OV | TCGA-24-2288-01A | PPFIBP1 | chr12 | 27677298 | + | MRPS35 | chr12 | 27867713 | + |
96980 | SARC | TCGA-DX-A1L0-01A | RBFA | chr18 | 77796710 | + | MRPS35 | chr12 | 27890472 | + |
96980 | PRAD | TCGA-4L-AA1F | SORBS2 | chr4 | 186568286 | - | MRPS35 | chr12 | 27908114 | + |
96980 | PRAD | TCGA-4L-AA1F-01A | SORBS2 | chr4 | 186570621 | - | MRPS35 | chr12 | 27908114 | + |
96980 | BRCA | TCGA-AC-A2QH-01A | STK38L | chr12 | 27455121 | + | MRPS35 | chr12 | 27908114 | + |
96980 | PRAD | TCGA-G9-6377-01A | UQCC1 | chr20 | 33902491 | - | MRPS35 | chr12 | 27888380 | + |
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Kaplan-Meier plots with logrank tests of overall survival (OS) |
Cancer type | Translation factor | Coefficent | Hazard ratio | Wald test pval | Likelihool ratio pval | Logrank test pval | # samples |
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Differential gene expression between female and male. (Wilcoxon test, pval<0.05) |
Cancer type | Translation factor | pval | adj.p |
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Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05) |
Cancer type | Translation factor | pval | adj.p |
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Drugs targeting genes involved in this translation factor. (DrugBank Version 5.1.8 2021-05-08) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Diseases associated with this translation factor. (DisGeNet 4.0) |
Disease ID | Disease Name | # PubMeds | Disease source |