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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: GUF1 (NCBI Gene ID:60558)

Gene Summary

Gene Summary

Gene Information	Gene Name: GUF1
	Gene ID: 60558
	Gene Symbol	GUF1
	Gene ID	60558
	Gene Name	GUF1 homolog, GTPase
	Synonyms	EF-4\|EF4\|EIEE40
	Cytomap	4p12
	Type of Gene	protein-coding
	Description	translation factor GUF1, mitochondrialGTP-binding protein GUF1 homologGTPase of unknown function 1elongation factor 4 homologribosomal back-translocase
	Modification date	20200320
	UniProtAcc	Q8N442

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0045727	Positive regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
GUF1	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'GUF1[title] AND translation [title] AND human.'

Gene	Title	PMID
GUF1	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000281543	44682457	44682569	Frame-shift
ENST00000281543	44687975	44688040	Frame-shift
ENST00000281543	44688526	44688730	In-frame
ENST00000281543	44690023	44690163	Frame-shift
ENST00000281543	44692733	44692877	In-frame
ENST00000281543	44693682	44693816	Frame-shift
ENST00000281543	44697631	44697751	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000281543	44688526	44688730	4466	929	1132	669	245	312
ENST00000281543	44692733	44692877	4466	1530	1673	669	445	493
ENST00000281543	44697631	44697751	4466	1910	2029	669	572	611

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q8N442	445	493	50	669	Chain	ID=PRO_0000256251;Note=Translation factor GUF1%2C mitochondrial
Q8N442	245	312	50	669	Chain	ID=PRO_0000256251;Note=Translation factor GUF1%2C mitochondrial
Q8N442	572	611	50	669	Chain	ID=PRO_0000256251;Note=Translation factor GUF1%2C mitochondrial
Q8N442	245	312	66	247	Domain	Note=tr-type G
Q8N442	572	611	609	609	Natural variant	ID=VAR_077804;Note=In EIEE40. A->S;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:26486472;Dbxref=dbSNP:rs879255631,PMID:26486472

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
STAD	GUF1	1.78219809177319	0.0044123362749815
BRCA	GUF1	1.16463029810538	0.0111057964084058
LUAD	GUF1	-2.12304746108755	1.70635806144212e-09
THCA	GUF1	2.19097653456855	2.3500379803691e-10
KICH	GUF1	1.92357268126527	4.54187393188476e-05
LUSC	GUF1	-2.1075832218076	7.28442422628201e-06

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
CESC	GUF1	hsa-miR-30e-5p	92	-0.310815766511969	0.00579535530534266
GBM	GUF1	hsa-miR-30b-5p	92	-1	0.0166666666666667
OV	GUF1	hsa-miR-30a-5p	88	0.341415521215743	0.0136302514624925

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
MESO	GUF1	-0.071553756	0.034851529

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with GUF1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type

Gene group

Translation factor

Correlated gene

Coefficient

Pvalue

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRC	GUF1	MRPL20	1.48585631024503	0.000111704804180407
COAD	GUF1	RPS3	1.48730375143014	0.000411599874496461
LUAD	GUF1	MRPL20	-3.00071204707904	0.000452706327224566
LIHC	GUF1	MRPL13	1.54402472107614	0.000655351190157038
BRCA	GUF1	MRPL20	-1.74379528461375	0.000756034430433012
KIRP	GUF1	MRPL19	-1.9689242575519	0.00179363833740354
LIHC	GUF1	MRPS7	1.27029395477208	0.00182077236082954
PRAD	GUF1	MRPS9	1.04379115553269	0.00496210155254694
KICH	GUF1	MRPL19	-2.18550705564541	0.00672554969787598
ESCA	GUF1	MRPL13	-1.07746088474995	0.0068359375
ESCA	GUF1	MRPL17	-1.18756178214998	0.009765625
LIHC	GUF1	MRPL17	-1.06225729770915	0.0124123499319886
LIHC	GUF1	MRPL20	-1.08735154161025	0.0158079482509981
HNSC	GUF1	RPS3	-4.73505819095135	0.0273726439852453
CHOL	GUF1	MRPL19	-2.09295650388558	0.0390625
STAD	GUF1	MRPL17	-3.90880705449186	1.49570405483246e-06
LUSC	GUF1	MRPS9	-3.60637641031661	1.82498668910368e-07
LUAD	GUF1	MRPS9	-1.32894454884901	1.98978698949574e-05
LUSC	GUF1	MRPL17	-6.83409683292749	6.93230040561614e-07
KIRC	GUF1	RPS3	-1.29560847926387	9.05905681935088e-10
BRCA	GUF1	MRPS7	-2.12787460270434	9.33194208595055e-10

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with GUF1

TNF, MRPS7, LAMP2, FAM174A, C5AR2, TMCO3, TSPYL6, IL13RA2, AGR2, MYC, MRM1, PDK1, TRMT61B, NR2C2, PSMD14, PLEKHA4, M, PARL, ESR1, IMMP2L, HSCB, ACAD9, AUH, C12orf65, C1QBP, C21orf33, C6orf203, MCUR1, CHCHD1, COX15, CS, DDX28, DHX30, GFM1, GRSF1, HINT2, ICT1, LONP1, LRPPRC, MDH2, METTL15, METTL17, MRPL11, MRPS12, MRPS26, MRRF, MTERF3, MTG2, MTIF2, MTIF3, MTRF1, MTRF1L, NGRN, PMPCA, RPUSD3, RPUSD4, SSBP1, TACO1, TBRG4, TFAM, TRUB2, TSFM, TUFM, VWA8, EXD2, CLPP, DNAJC19, AARS2, COX8A, PDHA1, TRAP1, SMAD4, LRRC25, PSCA, LRRC23, UQCRFS1, MALSU1, TNFSF14, SARS2, GCGR, MICB, TMEM9, MGARP, CEACAM8, FCGR3A, SLC22A15, PTH2R, PFDN5, PTCD1, P2RY10, MAGEA9, SSR2, OSTM1, RAMP2, AMACR, GPR45, YARS2, FAHD1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
GUF1	chr4	44680696	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant	SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant
GUF1	chr4	44680727	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant
GUF1	chr4	44682465	T	C	single_nucleotide_variant	Benign	Epileptic_encephalopathy,_early_infantile,_40	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
GUF1	chr4	44682716	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant
GUF1	chr4	44683156	G	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant
GUF1	chr4	44684357	C	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant
GUF1	chr4	44684455	C	T	single_nucleotide_variant	Benign	Epileptic_encephalopathy,_early_infantile,_40	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GUF1	chr4	44685224	T	TA	Insertion	Benign	Epileptic_encephalopathy,_early_infantile,_40	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GUF1	chr4	44685225	T	A	single_nucleotide_variant	Benign	Epileptic_encephalopathy,_early_infantile,_40	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GUF1	chr4	44685260	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant	SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant
GUF1	chr4	44685281	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant	SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant
GUF1	chr4	44685321	G	T	single_nucleotide_variant	Likely_benign	Long_QT_syndrome	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant
GUF1	chr4	44685328	G	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant
GUF1	chr4	44685345	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GUF1	chr4	44688540	C	T	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	not_provided	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant
GUF1	chr4	44688601	T	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant
GUF1	chr4	44691336	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
GUF1	chr4	44691890	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GUF1	chr4	44692781	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GUF1	chr4	44692784	TAAATC	T	Deletion	Uncertain_significance	not_specified	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
GUF1	chr4	44692830	A	G	single_nucleotide_variant	Uncertain_significance	not_specified	SO:0001583\|missense_variant	SO:0001583\|missense_variant
GUF1	chr4	44693710	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
GUF1	chr4	44693772	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GUF1	chr4	44696538	C	G	single_nucleotide_variant	Benign	Epileptic_encephalopathy,_early_infantile,_40	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GUF1	chr4	44697741	G	T	single_nucleotide_variant	Pathogenic	Epileptic_encephalopathy,_early_infantile,_40	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
GUF1	chr4	44699484	T	G	single_nucleotide_variant	Benign	Epileptic_encephalopathy,_early_infantile,_40	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GUF1	chr4	44700622	A	G	single_nucleotide_variant	Uncertain_significance	Epileptic_encephalopathy,_early_infantile,_40	SO:0001583\|missense_variant	SO:0001583\|missense_variant
GUF1	chr4	44700624	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GUF1	chr4	44700642	G	A	single_nucleotide_variant	Uncertain_significance	Epileptic_encephalopathy,_early_infantile,_40	SO:0001583\|missense_variant	SO:0001583\|missense_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
GUF1	KIRC	chr4	44696427	44696427	A	T	Splice_Site		4
GUF1	BRCA	chr4	44697709	44697709	C	A	Missense_Mutation	p.A598E	4
GUF1	ESCA	chr4	44690095	44690095	T	C	Missense_Mutation	p.L337S	3
GUF1	KIRP	chr4	44688034	44688034	T	C	Missense_Mutation	p.I243T	3
GUF1	ESCA	chr4	44700615	44700615	A	-	Frame_Shift_Del	p.K645fs	3
GUF1	PAAD	chr4	44691943	44691943	C	T	Missense_Mutation	p.T429I	3
GUF1	COAD	chr4	44688678	44688678	G	A	Missense_Mutation	p.E296K	3
GUF1	PRAD	chr4	44682800	44682800	G	A	Missense_Mutation	p.A123T	3
GUF1	LIHC	chr4	44682735	44682735	A	G	Missense_Mutation		3
GUF1	BRCA	chr4	44682858	44682858	C	G	Missense_Mutation	p.P142R	3
GUF1	LIHC	chr4	44700653	44700653	A	-	Frame_Shift_Del	p.P655fs	2
GUF1	STAD	chr4	44690074	44690074	A	G	Missense_Mutation	p.E330G	2
GUF1	KIRC	chr4	44696433	44696433	G	T	Missense_Mutation	p.D540Y	2
GUF1	KIRC	chr4	44696434	44696434	A	T	Missense_Mutation	p.D540V	2
GUF1	STAD	chr4	44691984	44691984	T	C	Silent		2
GUF1	UCEC	chr4	44682715	44682715	A	G	Missense_Mutation	p.Q57R	2
GUF1	LIHC	chr4	44692732	44692732	A	T	Splice_Site		2
GUF1	SKCM	chr4	44700577	44700577	C	-	Frame_Shift_Del	p.T630fs	2
GUF1	BLCA	chr4	44680684	44680684	C	T	Silent	p.L15L	2
GUF1	UCEC	chr4	44682859	44682859	G	T	Silent	p.P142	2
GUF1	PAAD	chr4	44691943	44691943	C	T	Missense_Mutation		2
GUF1	SKCM	chr4	44693752	44693752	C	T	Missense_Mutation	p.P517S	2
GUF1	BLCA	chr4	44693709	44693709	G	A	Missense_Mutation	p.M502I	2
GUF1	HNSC	chr4	44700691	44700691	C	G	Missense_Mutation	p.S668C	2
GUF1	UCEC	chr4	44684423	44684423	A	C	Missense_Mutation	p.N194H	2
GUF1	ESCA	chr4	44691414	44691414	G	A	Missense_Mutation	p.G397D	2
GUF1	LIHC	chr4	44693809	44693809	T	C	Missense_Mutation		2
GUF1	SKCM	chr4	44691374	44691374	T	G	Missense_Mutation	p.S384A	2
GUF1	HNSC	chr4	44688655	44688655	C	T	Missense_Mutation	p.S288F	2
GUF1	LUAD	chr4	44687997	44687997	A	G	Missense_Mutation	p.N231D	2
GUF1	UCEC	chr4	44688041	44688041	G	T	Splice_Site	e7+1	2
GUF1	ESCA	chr4	44690095	44690095	T	C	Missense_Mutation		2
GUF1	LIHC	chr4	44697656	44697656	A	T	Missense_Mutation		2
GUF1	LIHC	chr4	44693809	44693809	T	C	Missense_Mutation	p.Y536H	2
GUF1	HNSC	chr4	44688653	44688653	A	G	Silent	p.V287V	2
GUF1	STAD	chr4	44691984	44691984	T	C	Silent	p.L443L	2
GUF1	UCEC	chr4	44688623	44688623	C	T	Silent	p.D277	2
GUF1	ESCA	chr4	44700615	44700615	A	-	Frame_Shift_Del		2
GUF1	LIHC	chr4	44697656	44697656	A	T	Missense_Mutation	p.K580N	2
GUF1	PRAD	chr4	44692859	44692859	A	C	Missense_Mutation	p.K487N	2
GUF1	HNSC	chr4	44684387	44684387	G	A	Missense_Mutation	p.A182T	2
GUF1	LGG	chr4	44693681	44693681	A	G	Splice_Site		2
GUF1	UCEC	chr4	44691961	44691961	A	C	Missense_Mutation	p.K435T	2
GUF1	ESCA	chr4	44688650	44688650	T	A	Silent		2
GUF1	STAD	chr4	44699434	44699434	C	T	Silent	p.A615A	2
GUF1	UCEC	chr4	44696439	44696439	G	A	Missense_Mutation	p.E542K	2
GUF1	ESCA	chr4	44688650	44688650	T	A	Silent	p.I286I	2
GUF1	LIHC	chr4	44682735	44682735	A	G	Missense_Mutation	p.N101S	2
GUF1	HNSC	chr4	44680736	44680736	G	A	Missense_Mutation	p.A33T	2
GUF1	CESC	chr4	44691410	44691410	C	T	Silent		2
GUF1	STAD	chr4	44682845	44682845	C	T	Missense_Mutation	p.L138F	2
GUF1	LIHC	chr4	44699455	44699455	A	-	Frame_Shift_Del	p.A622fs	2
GUF1	STAD	chr4	44684428	44684428	G	T	Missense_Mutation	p.K195N	2
GUF1	BLCA	chr4	44693709	44693709	G	A	Missense_Mutation		1
GUF1	HNSC	chr4	44688653	44688653	A	G	Silent		1
GUF1	SARC	chr4	44692873	44692873	G	T	Missense_Mutation		1
GUF1	CESC	chr4	44691410	44691410	C	T	Silent	p.L396	1
GUF1	LIHC	chr4	44700581	44700581	A	-	Frame_Shift_Del	p.R631fs	1
GUF1	STAD	chr4	44692743	44692744	-	-	Frame_Shift_Ins		1
GUF1	DLBC	chr4	44680787	44680787	A	G	Missense_Mutation	p.S50G	1
GUF1	LIHC	chr4	44691387	44691387	T	C	Missense_Mutation		1
GUF1	MESO	chr4	44692779	44692779	C	T	Missense_Mutation		1
GUF1	UCEC	chr4	44691885	44691885	A	G	Missense_Mutation	p.M410V	1
GUF1	LIHC	chr4	44682727	44682727	A	-	Frame_Shift_Del	p.T98fs	1
GUF1	SARC	chr4	44697678	44697678	G	T	Missense_Mutation		1
GUF1	BLCA	chr4	44680749	44680749	G	A	Missense_Mutation		1
GUF1	HNSC	chr4	44700691	44700691	C	G	Missense_Mutation		1
GUF1	COAD	chr4	44680642	44680642	G	A	Missense_Mutation	p.M1I	1
GUF1	LIHC	chr4	44700614	44700615	-	A	Frame_Shift_Ins	p.GK642fs	1
GUF1	STAD	chr4	44692781	44692781	C	T	Silent		1
GUF1	UCEC	chr4	44700615	44700615	A	-	Frame_Shift_Del	p.K643fs	1
GUF1	ESCA	chr4	44688650	44688650	T	A	Silent	p.I286	1
GUF1	LIHC	chr4	44690145	44690145	A	G	Missense_Mutation		1
GUF1	MESO	chr4	44692779	44692779	C	T	Missense_Mutation	p.P461S	1
GUF1	STAD	chr4	44692743	44692744	-	A	Frame_Shift_Ins	p.K449fs	1
GUF1	LIHC	chr4	44682809	44682809	T	-	Frame_Shift_Del	p.F126fs	1
GUF1	SKCM	chr4	44700581	44700581	A	G	Silent	p.R631R	1
GUF1	BLCA	chr4	44700657	44700657	G	C	Missense_Mutation		1
GUF1	HNSC	chr4	44688655	44688655	C	T	Missense_Mutation		1
GUF1	COAD	chr4	44683190	44683190	G	T	Missense_Mutation	p.Q159H	1
GUF1	LUAD	chr4	44693729	44693729	G	C	Missense_Mutation	p.R509T	1
GUF1	OV	chr4	44377564	44377574	TCTTTTACAAT	-	Frame_Shift_Del	p.F126fs	1
GUF1	LIHC	chr4	44683151	44683151	T	-	Frame_Shift_Del	p.D146fs	1
GUF1	HNSC	chr4	44684387	44684387	G	A	Missense_Mutation		1
GUF1	COAD	chr4	44688034	44688035	-	C	Frame_Shift_Ins	p.I243fs	1
GUF1	LUAD	chr4	44688028	44688028	A	G	Missense_Mutation	p.E241G	1
GUF1	STAD	chr4	44700615	44700615	A	-	Frame_Shift_Del	p.G642fs	1
GUF1	STAD	chr4	44699460	44699460	G	A	Missense_Mutation	p.C624Y	1
GUF1	LIHC	chr4	44690074	44690074	A	G	Missense_Mutation		1
GUF1	LIHC	chr4	44691992	44691992	G	-	Splice_Site	p.K445_splice	1
GUF1	COAD	chr4	44688591	44688591	A	G	Missense_Mutation	p.R267G	1
GUF1	KIRP	chr4	44692823	44692823	G	A	Silent		1
GUF1	LUAD	chr4	44683138	44683138	A	T	Splice_Site		1
GUF1	STAD	chr4	44692743	44692744	-	A	Frame_Shift_Ins	p.E449fs	1
GUF1	STAD	chr4	44692771	44692771	C	G	Missense_Mutation	p.A458G	1
GUF1	LIHC	chr4	44680588	44680588	A	G	Missense_Mutation		1
GUF1	LIHC	chr4	44699433	44699433	C	-	Frame_Shift_Del	p.A615fs	1
GUF1	BLCA	chr4	44680749	44680749	G	A	Missense_Mutation	p.G37E	1
GUF1	KIRP	chr4	44688034	44688034	T	C	Missense_Mutation		1
GUF1	STAD	chr4	44692781	44692781	C	T	Silent	p.P461P	1
GUF1	STAD	chr4	44683221	44683221	G	A	Splice_Site	p.E169_splice	1
GUF1	LIHC	chr4	44699441	44699441	A	-	Frame_Shift_Del	p.K618fs	1
GUF1	SKCM	chr4	44684357	44684357	C	T	Nonsense_Mutation	p.Q172X	1
GUF1	BLCA	chr4	44700657	44700657	G	C	Missense_Mutation	p.D657H	1
GUF1	COAD	chr4	44693686	44693686	C	T	Nonsense_Mutation	p.R495X	1
GUF1	LGG	chr4	44693681	44693681	A	G	Splice_Site	.	1
GUF1	LUAD	chr4	44699458	44699458	A	C	Missense_Mutation	p.K623N	1
GUF1	STAD	chr4	44680700	44680700	G	T	Missense_Mutation	p.G21W	1
GUF1	LIHC	chr4	44684364	44684364	A	-	Frame_Shift_Del	p.Q174fs	1
GUF1	SKCM	chr4	44691954	44691954	C	T	Missense_Mutation	p.P433S	1
GUF1	COAD	chr4	44696438	44696438	C	T	Silent	p.Y541Y	1
GUF1	LUAD	chr4	44682821	44682821	G	A	Missense_Mutation	p.E130K	1
GUF1	STAD	chr4	44683221	44683221	G	A	Splice_Site	.	1
GUF1	THYM	chr4	44683194	44683194	G	T	Missense_Mutation		1
GUF1	LIHC	chr4	44697705	44697705	A	G	Missense_Mutation		1
GUF1	LIHC	chr4	44692732	44692732	A	T	Splice_Site	.	1
GUF1	PRAD	chr4	44691372	44691372	A	C	Missense_Mutation	p.D383A	1
GUF1	LIHC	chr4	44684422	44684422	A	-	Frame_Shift_Del	p.I193fs	1
GUF1	SKCM	chr4	44691384	44691384	C	T	Missense_Mutation	p.T387I	1
GUF1	HNSC	chr4	44682767	44682767	C	T	Nonsense_Mutation	p.R112*	1
GUF1	COAD	chr4	44700614	44700614	G	A	Silent	p.G642G	1
GUF1	LGG	chr4	44684369	44684369	G	C	Missense_Mutation	p.V176L	1
GUF1	LUAD	chr4	44682781	44682781	C	T	Silent	p.I116I	1
GUF1	THYM	chr4	44690132	44690132	G	A	Silent	p.G349G	1
GUF1	READ	chr4	44680652	44680652	G	C	Missense_Mutation	p.V5L	1
GUF1	LIHC	chr4	44690136	44690136	A	-	Frame_Shift_Del	p.K351fs	1
GUF1	SKCM	chr4	44688634	44688634	C	T	Missense_Mutation	p.S281F	1
GUF1	COAD	chr4	44700615	44700615	A	G	Missense_Mutation	p.K643E	1
GUF1	LGG	chr4	44682469	44682469	C	T	Silent	p.D59D	1
GUF1	LUAD	chr4	44693769	44693769	G	T	Silent	p.V522V	1
GUF1	THYM	chr4	44690115	44690115	G	T	Missense_Mutation	p.V344L	1
GUF1	ESCA	chr4	44691414	44691414	G	A	Missense_Mutation		1
GUF1	READ	chr4	44688550	44688550	C	A	Missense_Mutation	p.P253H	1
GUF1	CESC	chr4	44691410	44691410	C	T	Silent	p.L396L	1
GUF1	KIRC	chr4	44685329	44685330	-	AA	Frame_Shift_Ins	p.C221fs	1
GUF1	LIHC	chr4	44691980	44691980	A	-	Frame_Shift_Del	p.S441fs	1
GUF1	SKCM	chr4	44684357	44684357	C	T	Nonsense_Mutation	p.Q172*	1
GUF1	DLBC	chr4	44680660	44680660	G	A	Silent	p.R7R	1
GUF1	LGG	chr4	44684369	44684369	G	C	Missense_Mutation		1
GUF1	LUSC	chr4	44685270	44685270	G	A	Missense_Mutation	p.D202N	1
GUF1	THYM	chr4	44683194	44683194	G	T	Missense_Mutation	p.V161F	1

Copy number variation (CNV) of GUF1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across GUF1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
93458	N/A	AA227903	GUF1	chr4	44700627	-	ZNF354B	chr5	178309781	-
39434	HNSC	TCGA-CN-6024-01A	HUWE1	chrX	53707002	-	GUF1	chr4	44682711	+
39438	Non-Cancer	ERR315329	IL13RA1	chrX	117900939	+	GUF1	chr4	44691303	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	GUF1	0.00571103052050223	0.16
LUAD	GUF1	0.0115030884191576	0.31

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	GUF1	0.041531234340138	1
STAD	GUF1	0.00460999381332284	0.15
LGG	GUF1	0.000105118063929736	0.0035
BRCA	GUF1	0.0074279830780317	0.23

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0037769	West Syndrome	1	ORPHANET
C4310737	EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 40	1	CTD_human;GENOMICS_ENGLAND;UNIPROT