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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: ABCE1 (NCBI Gene ID:6059)

Gene Summary

Gene Summary

Gene Information	Gene Name: ABCE1
	Gene ID: 6059
	Gene Symbol	ABCE1
	Gene ID	6059
	Gene Name	ATP binding cassette subfamily E member 1
	Synonyms	ABC38\|OABP\|RLI\|RLI1\|RNASEL1\|RNASELI\|RNS4I
	Cytomap	4q31.21
	Type of Gene	protein-coding
	Description	ATP-binding cassette sub-family E member 12'-5'-oligoadenylate-binding proteinATP-binding cassette, sub-family E (OABP), member 1RNase L inhibitor 1huHP68ribonuclease 4 inhibitorribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) inhibitor
	Modification date	20200313
	UniProtAcc	P61221

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0006415	Translational termination
GO:0006413	Translational initiation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ABCE1	GO:0060702	negative regulation of endoribonuclease activity	7539425

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
ABCE1	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'ABCE1[title] AND translation [title] AND human.'

Gene	Title	PMID
ABCE1	Translation of ABCE1 Is Tightly Regulated by Upstream Open Reading Frames in Human Colorectal Cells	34440115

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000296577	146032119	146032216	Frame-shift
ENST00000296577	146042325	146042385	In-frame
ENST00000296577	146044629	146044752	In-frame
ENST00000296577	146046141	146046253	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000296577	146042325	146042385	3938	1660	1719	599	381	401
ENST00000296577	146044629	146044752	3938	2033	2155	599	506	546

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P61221	506	546	1	599	Chain	ID=PRO_0000093316;Note=ATP-binding cassette sub-family E member 1
P61221	381	401	1	599	Chain	ID=PRO_0000093316;Note=ATP-binding cassette sub-family E member 1
P61221	506	546	342	562	Domain	Note=ABC transporter 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00434
P61221	381	401	342	562	Domain	Note=ABC transporter 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00434
P61221	381	401	379	386	Nucleotide binding	Note=ATP 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00434

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
BRCA	ABCE1	1.3740626146648	0.000669229587514616
LIHC	ABCE1	1.33775121002715	0.0033398145023608
HNSC	ABCE1	1.20332081233659	0.0124875666290336
BLCA	ABCE1	-4.08863120087471	0.0229873657226562
PRAD	ABCE1	-2.9089513514626	1.31460603050763e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with ABCE1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
COAD	Cell metabolism gene	ABCE1	ENOPH1	0.811169268	3.54E-78
COAD	Cell metabolism gene	ABCE1	PAICS	0.816849288	3.98E-80
COAD	Cell metabolism gene	ABCE1	PPAT	0.850190871	4.02E-93
COAD	IUPHAR	ABCE1	PPAT	0.850190871	4.02E-93
DLBC	Cell metabolism gene	ABCE1	TGS1	0.801753465	7.52E-12
DLBC	Cell metabolism gene	ABCE1	POLR2B	0.804966586	5.36E-12
DLBC	Cell metabolism gene	ABCE1	PFAS	0.805151731	5.25E-12
DLBC	Cell metabolism gene	ABCE1	POLR3A	0.809149132	3.42E-12
DLBC	Cell metabolism gene	ABCE1	ME2	0.81402842	1.99E-12
DLBC	Cell metabolism gene	ABCE1	POLR1B	0.836518863	1.33E-13
DLBC	Cell metabolism gene	ABCE1	MCCC2	0.849134467	2.42E-14
DLBC	CGC	ABCE1	SUZ12	0.819064208	1.12E-12
DLBC	CGC	ABCE1	KRAS	0.820087746	9.97E-13
DLBC	CGC	ABCE1	PTPN11	0.82069296	9.29E-13
DLBC	CGC	ABCE1	RFWD3	0.822693274	7.34E-13
DLBC	CGC	ABCE1	TCF12	0.82997494	3.04E-13
DLBC	Epifactor	ABCE1	PCGF6	0.803279155	6.40E-12
DLBC	Epifactor	ABCE1	PARG	0.809199432	3.40E-12
DLBC	Epifactor	ABCE1	SUZ12	0.819064208	1.12E-12
DLBC	Epifactor	ABCE1	GLYR1	0.820321894	9.70E-13
DLBC	Epifactor	ABCE1	SMARCA5	0.854224607	1.16E-14
DLBC	IUPHAR	ABCE1	KRAS	0.820087746	9.97E-13
DLBC	IUPHAR	ABCE1	ATP2A2	0.826502522	4.65E-13
DLBC	TF	ABCE1	PCGF6	0.803279155	6.40E-12
DLBC	TF	ABCE1	GLYR1	0.820321894	9.70E-13
DLBC	TF	ABCE1	TCF12	0.82997494	3.04E-13
DLBC	TSG	ABCE1	RBL1	0.803459828	6.28E-12
DLBC	TSG	ABCE1	SUZ12	0.819064208	1.12E-12
DLBC	TSG	ABCE1	PTPN11	0.82069296	9.29E-13
DLBC	TSG	ABCE1	ANAPC1	0.821065511	8.89E-13
LAML	Cell metabolism gene	ABCE1	POLR1B	0.804839715	1.35E-40
LAML	Cell metabolism gene	ABCE1	TOMM70A	0.811607871	9.05E-42
LAML	Cell metabolism gene	ABCE1	PAICS	0.846770979	9.57E-49
LAML	Cell metabolism gene	ABCE1	PPAT	0.85801724	2.35E-51
LAML	CGC	ABCE1	MSH2	0.814620883	2.62E-42
LAML	IUPHAR	ABCE1	PPAT	0.85801724	2.35E-51
LAML	TSG	ABCE1	MSH2	0.814620883	2.62E-42
PRAD	TF	ABCE1	ZNF146	0.813673867	3.32E-131
SKCM	Cell metabolism gene	ABCE1	NUP54	0.818898567	6.85E-116
SKCM	Epifactor	ABCE1	SMARCAD1	0.814718858	8.72E-114
SKCM	Epifactor	ABCE1	SMARCA5	0.847796147	4.16E-132
TGCT	Cell metabolism gene	ABCE1	COL4A3BP	0.80123819	3.57E-36
TGCT	Cell metabolism gene	ABCE1	AMD1	0.816323305	1.53E-38
TGCT	Cell metabolism gene	ABCE1	ELOVL6	0.845007857	1.04E-43
TGCT	CGC	ABCE1	BUB1B	0.822289391	1.54E-39
TGCT	CGC	ABCE1	RFWD3	0.836212718	5.08E-42
TGCT	Epifactor	ABCE1	ZNF217	0.838396499	1.97E-42
TGCT	IUPHAR	ABCE1	NSMAF	0.816045862	1.70E-38
TGCT	IUPHAR	ABCE1	AMD1	0.816323305	1.53E-38
TGCT	IUPHAR	ABCE1	BUB1B	0.822289391	1.54E-39
TGCT	Kinase	ABCE1	COL4A3BP	0.80123819	3.57E-36
TGCT	Kinase	ABCE1	BUB1B	0.822289391	1.54E-39
TGCT	TF	ABCE1	ZNF770	0.805913008	6.94E-37
TGCT	TF	ABCE1	ZBTB39	0.811465041	9.34E-38
TGCT	TF	ABCE1	ZNF273	0.814467383	3.07E-38
TGCT	TF	ABCE1	ZNF721	0.81573706	1.91E-38
TGCT	TF	ABCE1	ZNF131	0.826554369	2.82E-40
TGCT	TF	ABCE1	ZNF217	0.838396499	1.97E-42
TGCT	TF	ABCE1	THAP9	0.842094237	3.86E-43
TGCT	TF	ABCE1	NFXL1	0.847925231	2.70E-44
TGCT	TSG	ABCE1	RB1CC1	0.815834551	1.84E-38
TGCT	TSG	ABCE1	PTPN12	0.838233929	2.12E-42
THYM	Cell metabolism gene	ABCE1	POLR2B	0.801027572	1.64E-28
THYM	Cell metabolism gene	ABCE1	NUP205	0.807513763	2.76E-29
THYM	Cell metabolism gene	ABCE1	ADSS	0.809125641	1.76E-29
THYM	Cell metabolism gene	ABCE1	NUP107	0.819417757	8.76E-31
THYM	Cell metabolism gene	ABCE1	ENOPH1	0.852007435	1.59E-35
THYM	Cell metabolism gene	ABCE1	PPAT	0.906763576	7.87E-47
THYM	CGC	ABCE1	TOP1	0.817776441	1.43E-30
THYM	Epifactor	ABCE1	TAF4	0.815932203	2.47E-30
THYM	IUPHAR	ABCE1	TOP1	0.817776441	1.43E-30
THYM	IUPHAR	ABCE1	PRMT3	0.838523937	1.95E-33
THYM	IUPHAR	ABCE1	PPAT	0.906763576	7.87E-47
THYM	TF	ABCE1	PRMT3	0.838523937	1.95E-33
THYM	TSG	ABCE1	CCAR1	0.827774837	6.65E-32
UCS	Cell metabolism gene	ABCE1	POLR2B	0.801027572	1.64E-28
UCS	Cell metabolism gene	ABCE1	NUP205	0.807513763	2.76E-29
UCS	Cell metabolism gene	ABCE1	ADSS	0.809125641	1.76E-29
UCS	Cell metabolism gene	ABCE1	NUP107	0.819417757	8.76E-31
UCS	Cell metabolism gene	ABCE1	ENOPH1	0.852007435	1.59E-35
UCS	Cell metabolism gene	ABCE1	PPAT	0.906763576	7.87E-47
UCS	CGC	ABCE1	TOP1	0.817776441	1.43E-30
UCS	Epifactor	ABCE1	TAF4	0.815932203	2.47E-30
UCS	IUPHAR	ABCE1	TOP1	0.817776441	1.43E-30
UCS	IUPHAR	ABCE1	PRMT3	0.838523937	1.95E-33
UCS	IUPHAR	ABCE1	PPAT	0.906763576	7.87E-47
UCS	TF	ABCE1	PRMT3	0.838523937	1.95E-33
UCS	TSG	ABCE1	CCAR1	0.827774837	6.65E-32
UVM	Cell metabolism gene	ABCE1	VBP1	0.800631073	4.97E-19
UVM	Cell metabolism gene	ABCE1	EPRS	0.801535251	4.24E-19
UVM	Cell metabolism gene	ABCE1	ACSL4	0.801644859	4.16E-19
UVM	Cell metabolism gene	ABCE1	FBXW7	0.802415895	3.63E-19
UVM	Cell metabolism gene	ABCE1	SDHD	0.802644809	3.49E-19
UVM	Cell metabolism gene	ABCE1	GRPEL2	0.806475518	1.75E-19
UVM	Cell metabolism gene	ABCE1	NUPL1	0.812250543	6.06E-20
UVM	Cell metabolism gene	ABCE1	BPNT1	0.812536392	5.74E-20
UVM	Cell metabolism gene	ABCE1	TNPO1	0.814366199	4.06E-20
UVM	Cell metabolism gene	ABCE1	ACADSB	0.815596522	3.21E-20
UVM	Cell metabolism gene	ABCE1	LYPLA1	0.815930152	3.02E-20
UVM	Cell metabolism gene	ABCE1	GNPDA2	0.817223739	2.35E-20
UVM	Cell metabolism gene	ABCE1	SEH1L	0.819174678	1.61E-20
UVM	Cell metabolism gene	ABCE1	MTR	0.820590585	1.22E-20
UVM	Cell metabolism gene	ABCE1	PIK3C2A	0.821187365	1.08E-20
UVM	Cell metabolism gene	ABCE1	MED4	0.821866736	9.47E-21
UVM	Cell metabolism gene	ABCE1	SACM1L	0.821875173	9.45E-21
UVM	Cell metabolism gene	ABCE1	PPP1CB	0.822231997	8.81E-21
UVM	Cell metabolism gene	ABCE1	PSMD14	0.822351072	8.60E-21
UVM	Cell metabolism gene	ABCE1	ALG10B	0.825288531	4.76E-21
UVM	Cell metabolism gene	ABCE1	PIGA	0.826790082	3.51E-21
UVM	Cell metabolism gene	ABCE1	ETNK1	0.828596684	2.42E-21
UVM	Cell metabolism gene	ABCE1	AGPS	0.829163016	2.15E-21
UVM	Cell metabolism gene	ABCE1	PNPLA8	0.832040064	1.17E-21
UVM	Cell metabolism gene	ABCE1	SPCS3	0.835347678	5.77E-22
UVM	Cell metabolism gene	ABCE1	UGGT2	0.836527212	4.47E-22
UVM	Cell metabolism gene	ABCE1	PRKAA1	0.837801591	3.38E-22
UVM	Cell metabolism gene	ABCE1	NUDT12	0.838263069	3.05E-22
UVM	Cell metabolism gene	ABCE1	MANEA	0.838418651	2.95E-22
UVM	Cell metabolism gene	ABCE1	NUP50	0.842208494	1.26E-22
UVM	Cell metabolism gene	ABCE1	NUP107	0.843174045	1.01E-22
UVM	Cell metabolism gene	ABCE1	POLR2B	0.843439018	9.52E-23
UVM	Cell metabolism gene	ABCE1	NAMPT	0.843765066	8.83E-23
UVM	Cell metabolism gene	ABCE1	FBXL3	0.844441237	7.56E-23
UVM	Cell metabolism gene	ABCE1	FAR1	0.845550089	5.85E-23
UVM	Cell metabolism gene	ABCE1	RANBP2	0.848383331	3.00E-23
UVM	Cell metabolism gene	ABCE1	SRP72	0.848990867	2.60E-23
UVM	Cell metabolism gene	ABCE1	DIS3	0.849347041	2.39E-23
UVM	Cell metabolism gene	ABCE1	DCK	0.851627874	1.38E-23
UVM	Cell metabolism gene	ABCE1	NUPL2	0.851628649	1.38E-23
UVM	Cell metabolism gene	ABCE1	SEC24B	0.854119129	7.49E-24
UVM	Cell metabolism gene	ABCE1	MED17	0.8552075	5.71E-24
UVM	Cell metabolism gene	ABCE1	CCT2	0.85570342	5.05E-24
UVM	Cell metabolism gene	ABCE1	CLOCK	0.858453157	2.52E-24
UVM	Cell metabolism gene	ABCE1	NUP54	0.859496328	1.93E-24
UVM	Cell metabolism gene	ABCE1	PLA2G12A	0.865968456	3.48E-25
UVM	Cell metabolism gene	ABCE1	PSMC6	0.868786273	1.61E-25
UVM	Cell metabolism gene	ABCE1	PPAT	0.870342684	1.04E-25
UVM	Cell metabolism gene	ABCE1	EDEM3	0.872468883	5.69E-26
UVM	Cell metabolism gene	ABCE1	XPO1	0.873894441	3.78E-26
UVM	Cell metabolism gene	ABCE1	ENOPH1	0.879513374	7.13E-27
UVM	Cell metabolism gene	ABCE1	MTMR6	0.879532413	7.09E-27
UVM	CGC	ABCE1	FBXW7	0.802415895	3.63E-19
UVM	CGC	ABCE1	SDHD	0.802644809	3.49E-19
UVM	CGC	ABCE1	HNRNPA2B1	0.802972174	3.29E-19
UVM	CGC	ABCE1	DDX5	0.803935195	2.77E-19
UVM	CGC	ABCE1	MSH2	0.805527749	2.08E-19
UVM	CGC	ABCE1	ATF1	0.807337316	1.50E-19
UVM	CGC	ABCE1	USP8	0.807674179	1.41E-19
UVM	CGC	ABCE1	PWWP2A	0.807774883	1.39E-19
UVM	CGC	ABCE1	ATRX	0.809156294	1.08E-19
UVM	CGC	ABCE1	SMAD4	0.814374718	4.06E-20
UVM	CGC	ABCE1	KTN1	0.816097347	2.92E-20
UVM	CGC	ABCE1	DICER1	0.816584416	2.66E-20
UVM	CGC	ABCE1	BCLAF1	0.82197996	9.26E-21
UVM	CGC	ABCE1	ARID2	0.825591763	4.48E-21
UVM	CGC	ABCE1	ETNK1	0.828596684	2.42E-21
UVM	CGC	ABCE1	HSP90AA1	0.828801049	2.32E-21
UVM	CGC	ABCE1	ZMYM2	0.830003241	1.80E-21
UVM	CGC	ABCE1	CASP3	0.834749795	6.57E-22
UVM	CGC	ABCE1	POT1	0.837570796	3.55E-22
UVM	CGC	ABCE1	BAZ1A	0.839506046	2.31E-22
UVM	CGC	ABCE1	RANBP2	0.848383331	3.00E-23
UVM	CGC	ABCE1	BMPR1A	0.848629276	2.83E-23
UVM	CGC	ABCE1	TET2	0.848647703	2.82E-23
UVM	CGC	ABCE1	CREB1	0.851585357	1.39E-23
UVM	CGC	ABCE1	SUZ12	0.851731818	1.34E-23
UVM	CGC	ABCE1	ATM	0.854324177	7.12E-24
UVM	CGC	ABCE1	CUL3	0.855484995	5.33E-24
UVM	CGC	ABCE1	SF3B1	0.857261643	3.41E-24
UVM	CGC	ABCE1	FIP1L1	0.860211067	1.60E-24
UVM	CGC	ABCE1	CDC73	0.863998916	5.91E-25
UVM	CGC	ABCE1	KIF5B	0.867918705	2.04E-25
UVM	CGC	ABCE1	FBXO11	0.870292261	1.06E-25
UVM	CGC	ABCE1	XPO1	0.873894441	3.78E-26
UVM	CGC	ABCE1	PMS1	0.873986255	3.68E-26
UVM	CGC	ABCE1	STAG2	0.884320704	1.60E-27
UVM	Epifactor	ABCE1	ATF2	0.801339918	4.39E-19
UVM	Epifactor	ABCE1	BRMS1L	0.801763074	4.07E-19
UVM	Epifactor	ABCE1	PCGF6	0.802281632	3.72E-19
UVM	Epifactor	ABCE1	EPC1	0.802753025	3.42E-19
UVM	Epifactor	ABCE1	FAM175A	0.803015769	3.26E-19
UVM	Epifactor	ABCE1	HAT1	0.803241203	3.14E-19
UVM	Epifactor	ABCE1	ARID4B	0.805192235	2.21E-19
UVM	Epifactor	ABCE1	ATRX	0.809156294	1.08E-19
UVM	Epifactor	ABCE1	UBE2D3	0.810265317	8.76E-20
UVM	Epifactor	ABCE1	CDK17	0.810295393	8.72E-20
UVM	Epifactor	ABCE1	SIRT1	0.810454683	8.46E-20
UVM	Epifactor	ABCE1	DNTTIP2	0.814221073	4.18E-20
UVM	Epifactor	ABCE1	RMI1	0.81427005	4.14E-20
UVM	Epifactor	ABCE1	INO80D	0.81450834	3.95E-20
UVM	Epifactor	ABCE1	USP15	0.819319018	1.56E-20
UVM	Epifactor	ABCE1	EPC2	0.819981554	1.37E-20
UVM	Epifactor	ABCE1	PARG	0.822553608	8.26E-21
UVM	Epifactor	ABCE1	TADA1	0.82277045	7.91E-21
UVM	Epifactor	ABCE1	BAZ2B	0.823545549	6.77E-21
UVM	Epifactor	ABCE1	ARID2	0.825591763	4.48E-21
UVM	Epifactor	ABCE1	BRCC3	0.825908648	4.20E-21
UVM	Epifactor	ABCE1	CTBP2	0.82638177	3.81E-21
UVM	Epifactor	ABCE1	CHD1	0.826915229	3.42E-21
UVM	Epifactor	ABCE1	CHD9	0.827992895	2.74E-21
UVM	Epifactor	ABCE1	DDX50	0.828437751	2.50E-21
UVM	Epifactor	ABCE1	ZMYND11	0.828570853	2.43E-21
UVM	Epifactor	ABCE1	ZMYM2	0.830003241	1.80E-21
UVM	Epifactor	ABCE1	TAF7	0.830590319	1.59E-21
UVM	Epifactor	ABCE1	PHF14	0.83071435	1.55E-21
UVM	Epifactor	ABCE1	PHF20L1	0.831568142	1.30E-21
UVM	Epifactor	ABCE1	OGT	0.832054309	1.17E-21
UVM	Epifactor	ABCE1	ZRANB3	0.83279948	9.98E-22
UVM	Epifactor	ABCE1	PHIP	0.832947013	9.68E-22
UVM	Epifactor	ABCE1	ACTR6	0.835088456	6.11E-22
UVM	Epifactor	ABCE1	MASTL	0.835320293	5.81E-22
UVM	Epifactor	ABCE1	ARID4A	0.836285883	4.71E-22
UVM	Epifactor	ABCE1	YY1	0.836347875	4.65E-22
UVM	Epifactor	ABCE1	NIPBL	0.836910297	4.11E-22
UVM	Epifactor	ABCE1	PRKAA1	0.837801591	3.38E-22
UVM	Epifactor	ABCE1	BAZ1A	0.839506046	2.31E-22
UVM	Epifactor	ABCE1	AEBP2	0.841336921	1.53E-22
UVM	Epifactor	ABCE1	UCHL5	0.846630324	4.54E-23
UVM	Epifactor	ABCE1	TET2	0.848647703	2.82E-23
UVM	Epifactor	ABCE1	CBX3	0.849823154	2.13E-23
UVM	Epifactor	ABCE1	HMGB1	0.851515721	1.42E-23
UVM	Epifactor	ABCE1	SUZ12	0.851731818	1.34E-23
UVM	Epifactor	ABCE1	TLK1	0.852899668	1.01E-23
UVM	Epifactor	ABCE1	RLIM	0.853500543	8.72E-24
UVM	Epifactor	ABCE1	ATM	0.854324177	7.12E-24
UVM	Epifactor	ABCE1	ATAD2B	0.854706999	6.47E-24
UVM	Epifactor	ABCE1	CUL3	0.855484995	5.33E-24
UVM	Epifactor	ABCE1	CUL5	0.856131105	4.53E-24
UVM	Epifactor	ABCE1	FAM175B	0.857084399	3.57E-24
UVM	Epifactor	ABCE1	SF3B1	0.857261643	3.41E-24
UVM	Epifactor	ABCE1	JMJD1C	0.857949055	2.86E-24
UVM	Epifactor	ABCE1	CLOCK	0.858453157	2.52E-24
UVM	Epifactor	ABCE1	SMARCA5	0.860512086	1.48E-24
UVM	Epifactor	ABCE1	CDC73	0.863998916	5.91E-25
UVM	Epifactor	ABCE1	SMEK1	0.869846771	1.20E-25
UVM	Epifactor	ABCE1	NSL1	0.871730585	7.03E-26
UVM	Epifactor	ABCE1	SMARCAD1	0.873997301	3.67E-26
UVM	Epifactor	ABCE1	YEATS4	0.874731757	2.96E-26
UVM	Epifactor	ABCE1	SMEK2	0.892259885	1.17E-28
UVM	Epifactor	ABCE1	CUL2	0.897282245	2.00E-29
UVM	IUPHAR	ABCE1	EGLN1	0.80027603	5.29E-19
UVM	IUPHAR	ABCE1	PRPF4B	0.800881381	4.76E-19
UVM	IUPHAR	ABCE1	RIOK3	0.801862571	4.00E-19
UVM	IUPHAR	ABCE1	HAT1	0.803241203	3.14E-19
UVM	IUPHAR	ABCE1	SLC30A9	0.803610301	2.94E-19
UVM	IUPHAR	ABCE1	SLK	0.80475626	2.39E-19
UVM	IUPHAR	ABCE1	ADAM17	0.805561996	2.07E-19
UVM	IUPHAR	ABCE1	RIOK2	0.807816341	1.38E-19
UVM	IUPHAR	ABCE1	STK17A	0.808778105	1.15E-19
UVM	IUPHAR	ABCE1	CDK17	0.810295393	8.72E-20
UVM	IUPHAR	ABCE1	SIRT1	0.810454683	8.46E-20
UVM	IUPHAR	ABCE1	MAPK6	0.81055895	8.30E-20
UVM	IUPHAR	ABCE1	ATP11C	0.81150397	6.96E-20
UVM	IUPHAR	ABCE1	IRAK4	0.811775556	6.62E-20
UVM	IUPHAR	ABCE1	PKN2	0.811807182	6.58E-20
UVM	IUPHAR	ABCE1	TNKS2	0.814352048	4.07E-20
UVM	IUPHAR	ABCE1	SLC25A46	0.818325001	1.90E-20
UVM	IUPHAR	ABCE1	MAP3K2	0.820235933	1.31E-20
UVM	IUPHAR	ABCE1	TRPM7	0.820296426	1.29E-20
UVM	IUPHAR	ABCE1	MTR	0.820590585	1.22E-20
UVM	IUPHAR	ABCE1	USP14	0.821038683	1.12E-20
UVM	IUPHAR	ABCE1	PIK3C2A	0.821187365	1.08E-20
UVM	IUPHAR	ABCE1	XIAP	0.822174731	8.91E-21
UVM	IUPHAR	ABCE1	PSMD14	0.822351072	8.60E-21
UVM	IUPHAR	ABCE1	TMEM165	0.822465695	8.41E-21
UVM	IUPHAR	ABCE1	SLC30A5	0.823506803	6.82E-21
UVM	IUPHAR	ABCE1	BAZ2B	0.823545549	6.77E-21
UVM	IUPHAR	ABCE1	BMPR2	0.824443011	5.65E-21
UVM	IUPHAR	ABCE1	NEK7	0.82654393	3.69E-21
UVM	IUPHAR	ABCE1	ZMYND11	0.828570853	2.43E-21
UVM	IUPHAR	ABCE1	HSP90AA1	0.828801049	2.32E-21
UVM	IUPHAR	ABCE1	PHIP	0.832947013	9.68E-22
UVM	IUPHAR	ABCE1	PRMT3	0.834451071	7.01E-22
UVM	IUPHAR	ABCE1	CASP3	0.834749795	6.57E-22
UVM	IUPHAR	ABCE1	MASTL	0.835320293	5.81E-22
UVM	IUPHAR	ABCE1	ABCB10	0.83607111	4.93E-22
UVM	IUPHAR	ABCE1	PLK4	0.836647736	4.35E-22
UVM	IUPHAR	ABCE1	MAP4K3	0.836991072	4.04E-22
UVM	IUPHAR	ABCE1	PRKAA1	0.837801591	3.38E-22
UVM	IUPHAR	ABCE1	BAZ1A	0.839506046	2.31E-22
UVM	IUPHAR	ABCE1	CSNK1G3	0.839960511	2.09E-22
UVM	IUPHAR	ABCE1	VRK2	0.841212996	1.58E-22
UVM	IUPHAR	ABCE1	BIRC2	0.842677957	1.13E-22
UVM	IUPHAR	ABCE1	MAGT1	0.846964283	4.20E-23
UVM	IUPHAR	ABCE1	BMPR1A	0.848629276	2.83E-23
UVM	IUPHAR	ABCE1	TLK1	0.852899668	1.01E-23
UVM	IUPHAR	ABCE1	ATM	0.854324177	7.12E-24
UVM	IUPHAR	ABCE1	ATAD2B	0.854706999	6.47E-24
UVM	IUPHAR	ABCE1	JMJD1C	0.857949055	2.86E-24
UVM	IUPHAR	ABCE1	CLOCK	0.858453157	2.52E-24
UVM	IUPHAR	ABCE1	TBK1	0.863177964	7.35E-25
UVM	IUPHAR	ABCE1	PLA2G12A	0.865968456	3.48E-25
UVM	IUPHAR	ABCE1	FBXO11	0.870292261	1.06E-25
UVM	IUPHAR	ABCE1	PPAT	0.870342684	1.04E-25
UVM	IUPHAR	ABCE1	XPO1	0.873894441	3.78E-26
UVM	IUPHAR	ABCE1	NEK1	0.890923548	1.84E-28
UVM	Kinase	ABCE1	PRPF4B	0.800881381	4.76E-19
UVM	Kinase	ABCE1	RIOK3	0.801862571	4.00E-19
UVM	Kinase	ABCE1	SLK	0.80475626	2.39E-19
UVM	Kinase	ABCE1	RIOK2	0.807816341	1.38E-19
UVM	Kinase	ABCE1	STK17A	0.808778105	1.15E-19
UVM	Kinase	ABCE1	CDK17	0.810295393	8.72E-20
UVM	Kinase	ABCE1	MAPK6	0.81055895	8.30E-20
UVM	Kinase	ABCE1	IRAK4	0.811775556	6.62E-20
UVM	Kinase	ABCE1	PKN2	0.811807182	6.58E-20
UVM	Kinase	ABCE1	MAP3K2	0.820235933	1.31E-20
UVM	Kinase	ABCE1	TRPM7	0.820296426	1.29E-20
UVM	Kinase	ABCE1	BMPR2	0.824443011	5.65E-21
UVM	Kinase	ABCE1	NEK7	0.82654393	3.69E-21
UVM	Kinase	ABCE1	MASTL	0.835320293	5.81E-22
UVM	Kinase	ABCE1	PLK4	0.836647736	4.35E-22
UVM	Kinase	ABCE1	MAP4K3	0.836991072	4.04E-22
UVM	Kinase	ABCE1	PRKAA1	0.837801591	3.38E-22
UVM	Kinase	ABCE1	BAZ1A	0.839506046	2.31E-22
UVM	Kinase	ABCE1	CSNK1G3	0.839960511	2.09E-22
UVM	Kinase	ABCE1	VRK2	0.841212996	1.58E-22
UVM	Kinase	ABCE1	BMPR1A	0.848629276	2.83E-23
UVM	Kinase	ABCE1	TLK1	0.852899668	1.01E-23
UVM	Kinase	ABCE1	ATM	0.854324177	7.12E-24
UVM	Kinase	ABCE1	TBK1	0.863177964	7.35E-25
UVM	Kinase	ABCE1	NEK1	0.890923548	1.84E-28
UVM	TF	ABCE1	ZNF207	0.800485887	5.10E-19
UVM	TF	ABCE1	ZNF566	0.800740863	4.87E-19
UVM	TF	ABCE1	ADNP2	0.801019281	4.64E-19
UVM	TF	ABCE1	ATF2	0.801339918	4.39E-19
UVM	TF	ABCE1	PCGF6	0.802281632	3.72E-19
UVM	TF	ABCE1	ZNF470	0.802830903	3.37E-19
UVM	TF	ABCE1	ZNF234	0.802849462	3.36E-19
UVM	TF	ABCE1	ZNF141	0.803850681	2.81E-19
UVM	TF	ABCE1	ZNF248	0.804478799	2.51E-19
UVM	TF	ABCE1	ZNF480	0.805040081	2.27E-19
UVM	TF	ABCE1	ZNF432	0.805627565	2.05E-19
UVM	TF	ABCE1	ATF1	0.807337316	1.50E-19
UVM	TF	ABCE1	ZNF260	0.807719803	1.40E-19
UVM	TF	ABCE1	ZFX	0.808186062	1.29E-19
UVM	TF	ABCE1	ZNF845	0.809266198	1.05E-19
UVM	TF	ABCE1	ZNF420	0.80990358	9.37E-20
UVM	TF	ABCE1	ZNF451	0.809916423	9.35E-20
UVM	TF	ABCE1	ZNF606	0.810582339	8.26E-20
UVM	TF	ABCE1	ZNF84	0.81119217	7.38E-20
UVM	TF	ABCE1	ZNF37A	0.811334172	7.19E-20
UVM	TF	ABCE1	ZNF721	0.811351809	7.16E-20
UVM	TF	ABCE1	ZNF507	0.811857121	6.52E-20
UVM	TF	ABCE1	ZNF430	0.812183421	6.13E-20
UVM	TF	ABCE1	ZNF254	0.812322606	5.97E-20
UVM	TF	ABCE1	SMAD4	0.814374718	4.06E-20
UVM	TF	ABCE1	TOPORS	0.814787182	3.75E-20
UVM	TF	ABCE1	ZNF182	0.814829386	3.72E-20
UVM	TF	ABCE1	ZNF680	0.815210247	3.46E-20
UVM	TF	ABCE1	ZNF701	0.817839221	2.09E-20
UVM	TF	ABCE1	ZNF484	0.818004861	2.02E-20
UVM	TF	ABCE1	ZNF383	0.818312092	1.90E-20
UVM	TF	ABCE1	ZNF92	0.818791751	1.73E-20
UVM	TF	ABCE1	ZNF25	0.81954178	1.50E-20
UVM	TF	ABCE1	ZNF449	0.820197387	1.32E-20
UVM	TF	ABCE1	ZNF143	0.823241465	7.20E-21
UVM	TF	ABCE1	BAZ2B	0.823545549	6.77E-21
UVM	TF	ABCE1	ZNF431	0.8241254	6.03E-21
UVM	TF	ABCE1	ZNF302	0.825301477	4.75E-21
UVM	TF	ABCE1	ARID2	0.825591763	4.48E-21
UVM	TF	ABCE1	ZBED5	0.825661938	4.41E-21
UVM	TF	ABCE1	ZNF14	0.826453788	3.76E-21
UVM	TF	ABCE1	ZNF24	0.826470558	3.74E-21
UVM	TF	ABCE1	ZNF567	0.827156308	3.25E-21
UVM	TF	ABCE1	ZBTB6	0.827498692	3.03E-21
UVM	TF	ABCE1	ELF1	0.828782217	2.32E-21
UVM	TF	ABCE1	ZNF708	0.828991868	2.23E-21
UVM	TF	ABCE1	FOXN2	0.829876253	1.85E-21
UVM	TF	ABCE1	GABPA	0.830000779	1.80E-21
UVM	TF	ABCE1	ZNF780A	0.831491377	1.32E-21
UVM	TF	ABCE1	ZNF138	0.832572978	1.05E-21
UVM	TF	ABCE1	ZNF658	0.833673445	8.28E-22
UVM	TF	ABCE1	PRMT3	0.834451071	7.01E-22
UVM	TF	ABCE1	ZNF441	0.835843299	5.18E-22
UVM	TF	ABCE1	YY1	0.836347875	4.65E-22
UVM	TF	ABCE1	ZNF75D	0.836589411	4.41E-22
UVM	TF	ABCE1	ZNF195	0.836752896	4.25E-22
UVM	TF	ABCE1	ZNF518A	0.836878498	4.14E-22
UVM	TF	ABCE1	ZNF527	0.83783282	3.35E-22
UVM	TF	ABCE1	BACH1	0.8382758	3.04E-22
UVM	TF	ABCE1	ZNF267	0.838549296	2.86E-22
UVM	TF	ABCE1	PURB	0.839889777	2.12E-22
UVM	TF	ABCE1	PRDM10	0.840107485	2.02E-22
UVM	TF	ABCE1	CREBZF	0.840275963	1.95E-22
UVM	TF	ABCE1	ZNF28	0.840312266	1.93E-22
UVM	TF	ABCE1	DMTF1	0.840633388	1.80E-22
UVM	TF	ABCE1	ZNF675	0.841103917	1.62E-22
UVM	TF	ABCE1	ZNF280D	0.841141265	1.60E-22
UVM	TF	ABCE1	AEBP2	0.841336921	1.53E-22
UVM	TF	ABCE1	ZNF43	0.841938079	1.34E-22
UVM	TF	ABCE1	ZNF791	0.842532134	1.17E-22
UVM	TF	ABCE1	ZNF41	0.84413312	8.11E-23
UVM	TF	ABCE1	ZNF136	0.844260938	7.88E-23
UVM	TF	ABCE1	SMAD5	0.844438022	7.56E-23
UVM	TF	ABCE1	ZNF33A	0.844523953	7.41E-23
UVM	TF	ABCE1	ZNF146	0.844599627	7.29E-23
UVM	TF	ABCE1	ZNF510	0.844810367	6.94E-23
UVM	TF	ABCE1	LIN54	0.844824931	6.92E-23
UVM	TF	ABCE1	ZNF800	0.845659167	5.70E-23
UVM	TF	ABCE1	ZBTB41	0.845669399	5.69E-23
UVM	TF	ABCE1	AHCTF1	0.846811878	4.35E-23
UVM	TF	ABCE1	ZNF546	0.847490441	3.71E-23
UVM	TF	ABCE1	ZNF180	0.847586216	3.63E-23
UVM	TF	ABCE1	GPBP1	0.848639795	2.83E-23
UVM	TF	ABCE1	TET2	0.848647703	2.82E-23
UVM	TF	ABCE1	ZNF12	0.850495034	1.81E-23
UVM	TF	ABCE1	ZNF140	0.850824683	1.68E-23
UVM	TF	ABCE1	CREB1	0.851585357	1.39E-23
UVM	TF	ABCE1	ZNF181	0.85237759	1.15E-23
UVM	TF	ABCE1	SP3	0.853362438	9.02E-24
UVM	TF	ABCE1	CLOCK	0.858453157	2.52E-24
UVM	TF	ABCE1	ZNF268	0.859286407	2.03E-24
UVM	TF	ABCE1	CEBPZ	0.861306348	1.20E-24
UVM	TF	ABCE1	RBAK	0.863613127	6.55E-25
UVM	TF	ABCE1	ZNF26	0.86402045	5.88E-25
UVM	TF	ABCE1	THAP5	0.868279446	1.85E-25
UVM	TF	ABCE1	ZBTB1	0.872592402	5.49E-26
UVM	TF	ABCE1	IKZF5	0.873903237	3.77E-26
UVM	TF	ABCE1	ZNF131	0.875957808	2.07E-26
UVM	TF	ABCE1	THAP9	0.881507789	3.87E-27
UVM	TF	ABCE1	THAP6	0.890744383	1.96E-28
UVM	TF	ABCE1	ELF2	0.912223927	5.82E-32
UVM	TSG	ABCE1	EGLN1	0.80027603	5.29E-19
UVM	TSG	ABCE1	FBXW7	0.802415895	3.63E-19
UVM	TSG	ABCE1	SDHD	0.802644809	3.49E-19
UVM	TSG	ABCE1	IFT88	0.803208776	3.15E-19
UVM	TSG	ABCE1	GGNBP2	0.803304297	3.10E-19
UVM	TSG	ABCE1	MSH2	0.805527749	2.08E-19
UVM	TSG	ABCE1	SIRT1	0.810454683	8.46E-20
UVM	TSG	ABCE1	PTPN12	0.814164498	4.22E-20
UVM	TSG	ABCE1	WDR11	0.814241674	4.16E-20
UVM	TSG	ABCE1	SMAD4	0.814374718	4.06E-20
UVM	TSG	ABCE1	TOPORS	0.814787182	3.75E-20
UVM	TSG	ABCE1	NEDD4	0.815661837	3.17E-20
UVM	TSG	ABCE1	DICER1	0.816584416	2.66E-20
UVM	TSG	ABCE1	PDS5B	0.81697895	2.46E-20
UVM	TSG	ABCE1	TANK	0.817108487	2.40E-20
UVM	TSG	ABCE1	GTPBP4	0.821260345	1.07E-20
UVM	TSG	ABCE1	BMPR2	0.824443011	5.65E-21
UVM	TSG	ABCE1	COPS2	0.824850993	5.20E-21
UVM	TSG	ABCE1	PPM1A	0.825360436	4.69E-21
UVM	TSG	ABCE1	ARID2	0.825591763	4.48E-21
UVM	TSG	ABCE1	RBBP8	0.82567904	4.40E-21
UVM	TSG	ABCE1	CHD1	0.826915229	3.42E-21
UVM	TSG	ABCE1	GORAB	0.828275759	2.58E-21
UVM	TSG	ABCE1	ZMYND11	0.828570853	2.43E-21
UVM	TSG	ABCE1	RB1CC1	0.830553896	1.61E-21
UVM	TSG	ABCE1	PRKAA1	0.837801591	3.38E-22
UVM	TSG	ABCE1	CCAR1	0.837981368	3.25E-22
UVM	TSG	ABCE1	MLH3	0.838162375	3.12E-22
UVM	TSG	ABCE1	VEZT	0.840151581	2.00E-22
UVM	TSG	ABCE1	DMTF1	0.840633388	1.80E-22
UVM	TSG	ABCE1	LIN9	0.840926595	1.68E-22
UVM	TSG	ABCE1	DCLRE1A	0.845970239	5.30E-23
UVM	TSG	ABCE1	BMPR1A	0.848629276	2.83E-23
UVM	TSG	ABCE1	TET2	0.848647703	2.82E-23
UVM	TSG	ABCE1	FAM188A	0.850735125	1.71E-23
UVM	TSG	ABCE1	SUZ12	0.851731818	1.34E-23
UVM	TSG	ABCE1	ATM	0.854324177	7.12E-24
UVM	TSG	ABCE1	KRIT1	0.855532334	5.27E-24
UVM	TSG	ABCE1	CUL5	0.856131105	4.53E-24
UVM	TSG	ABCE1	RINT1	0.860496096	1.49E-24
UVM	TSG	ABCE1	CDC73	0.863998916	5.91E-25
UVM	TSG	ABCE1	SMCHD1	0.872209178	6.13E-26
UVM	TSG	ABCE1	INTS6	0.885984139	9.40E-28
UVM	TSG	ABCE1	CUL2	0.897282245	2.00E-29

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
BLCA	ABCE1	ETF1	-5.5294928877253	0.000125885009765625
KICH	ABCE1	EIF3I	1.57310069220802	0.000139892101287842
LUSC	ABCE1	ETF1	-1.14997231039675	0.000173983823784929
HNSC	ABCE1	EIF1	-4.13399438210909	0.000228392819053625
PRAD	ABCE1	EIF3A	1.13680328391952	0.000363360004697762
LIHC	ABCE1	HBS1L	-3.51830003681254	0.000568486322514105
LUAD	ABCE1	GNB2L1	-2.23706676970836	0.00121089428940613
LIHC	ABCE1	EIF3C	-1.23074521883972	0.00126327311470459
BRCA	ABCE1	EIF3I	-1.72233459275531	0.00191218761269043
LUAD	ABCE1	EIF3J	-1.1109238877878	0.00216965225011196
KICH	ABCE1	EIF2S2	-1.06278646532411	0.00308787822723389
LUAD	ABCE1	HBS1L	-3.79049220477362	0.00334247187092709
BLCA	ABCE1	EIF3A	-4.45104058307747	0.00532913208007812
KIRC	ABCE1	ETF1	-2.84641542192603	0.00644033795389533
PRAD	ABCE1	EIF1	1.32822648991353	0.00674237731133815
COAD	ABCE1	HBS1L	-2.33101802408262	0.0140064954757691
HNSC	ABCE1	HBS1L	-1.05185243210432	0.0462444565380338
LUAD	ABCE1	EIF3B	-5.80435587546762	1.0542655358657e-09
THCA	ABCE1	EIF3J	1.32428508175103	1.19078203681914e-07
BRCA	ABCE1	EIF2S2	-2.57303037687825	1.70212120584918e-09
LUAD	ABCE1	ETF1	-2.01649649887837	2.27155024792558e-09
KIRC	ABCE1	EIF3B	-1.56313263784517	2.35252849767166e-12
STAD	ABCE1	EIF2S2	-2.13186277769467	3.17529775202275e-05
KICH	ABCE1	EIF3J	2.09716749126717	3.19480895996094e-05
STAD	ABCE1	EIF3B	-4.7724660972007	3.25962901115418e-08
HNSC	ABCE1	EIF3B	2.6202554263604	4.48234413852334e-06
KIRP	ABCE1	EIF3B	-2.7592297042974	4.6566128730774e-09
PRAD	ABCE1	GNB2L1	2.22079570419983	6.51372327512043e-05
BRCA	ABCE1	EIF3A	-1.218215573148	7.39403582934137e-06

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with ABCE1

RNASEL, EIF3H, EIF3F, USP50, UBASH3A, gag, SIRT7, CUL3, ITGA4, MMS19, FBXO6, PARK2, AP1B1, DIABLO, PDIA3, ILK, DCP2, STAU1, FAM96B, CIAO1, RNF2, ABCF1, FUBP3, CBX3, PDHA1, ABLIM1, CNIH4, NAA10, PSMD4, CORO1C, MAPK1, SRP9, TIMM21, SNAP23, HIST1H1C, EPB41L3, CUL4A, ZNF207, PRCP, TTC29, WDR1, EIF3D, EWSR1, PAK3, TIMM23, PFDN2, H3F3C, HIST2H2BF, FLNB, SAE1, PTGES3, PSMD13, STRAP, WDR77, TPP1, GNS, PPP2R2A, CD44, ATP6V1A, ISYNA1, ETF1, CCNY, IMMT, C16orf96, RRP1B, RFC4, RPL32, PEBP1, TFAM, TCEB1, FLOT2, SSFA2, GSPT1, NAT10, AARS, MAP4, MYO6, FLNA, RAVER1, RBBP7, ASNS, FDPS, RRP12, KARS, EPB41, HMGB1P1, SFXN4, TSN, RPRD1B, CD59, ORAOV1, SRRM2, SMARCA5, POLR1B, SAFB, RAB35, SUCLG2, MED23, VDAC3, PPM1G, MFGE8, DDX18, HAX1, NDUFA4, PSMD14, PPP6C, SURF4, ARPC5, EPB41L2, DKC1, PSIP1, RP2, CBR3, FLOT1, UFL1, AIFM1, PNP, LMNA, CSTB, TP53, FYN, HEXB, LYN, VIM, PTPRF, CTSA, RALA, IGF2R, SLC25A4, SRC, PRKAR2A, JUP, GLB1, PRKACA, PFKL, RPL35A, GNAZ, SRM, LMNB1, SDHB, FBL, ACAT1, RPS12, PSMA2, MSN, APEX1, PSMA5, GNA11, KIF5B, DUT, PSMC2, PPP1CC, EIF4A3, TMPO, RPS27, VDAC2, CBX5, RPL21, MAP1B, IQGAP1, PSMD8, PSMB3, GNAQ, CACNA2D1, AK2, S100A10, ABCE1, RAP2B, HSPE1, PPP1CB, RPS29, SNRPF, RPS25, GNB1, DYNLL1, GNG5, ANK2, LMNB2, YWHAH, TWF1, DSG2, SMC1A, NUMA1, EBP, TOMM20, SF3A1, MAPRE1, NDUFA5, C14orf166, AIF1L, ULBP3, TTC37, DDX46, DCXR, DNAJC7, PEG10, GAS2L3, GADD45GIP1, KIAA1524, HM13, C2orf47, ATXN2L, USP7, MACF1, PSMD1, SDF4, TBCD, CPVL, GNB4, EXOSC4, YAE1D1, SMC4, MDN1, FANCI, TECR, CISD1, NDUFAF4, NDUFA13, STARD9, ATXN10, CPSF3, RPL36, SUPT16H, PTER, RPL7, RPS3A, VAPA, VAPB, RPL4, NTRK1, POC5, TMEM17, TMEM216, CENPJ, XPO1, XRCC5, Brca1, Kif13b, Cdc6, Sidt2, MCM2, DNM1L, EGLN3, RIPK4, HSPA8, CTNNB1, RNF123, AGR2, HRAS, KRAS, NRAS, WWOX, MB21D1, MYC, TGOLN2, EEA1, KIAA1429, ATG16L1, CCND1, NR2C2, HDAC2, DYRK1A, DUSP22, ITFG1, GSK3B, BIRC3, BRD7, TRIM28, TEX101, EIF3J, PLEKHA4, KCTD10, BMX, EGFR, RIPK1, SOCS1, M, nsp6, ORF8, MAP1LC3B, HSCB, BRD4, Apc2, NR3C1, CD274, AKAP1, ANAPC2, POLR2C, TUBA4A, WDR5, NAA40, SPRTN, USP11, EP300, TMPRSS2, CTSB, FURIN, DPP4, IFITM3, TMPRSS11B, nsp4,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
ABCE1	chr4	146030326	A	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
ABCE1	chr4	146031603	G	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
ABCE1	chr4	146032214	T	G	single_nucleotide_variant	Uncertain_significance	Malignant_tumor_of_prostate	SO:0001583\|missense_variant	SO:0001583\|missense_variant
ABCE1	chr4	146033406	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
ABCE1	chr4	146044417	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
ABCE1	KIRP	chr4	146041306	146041306	G	A	Splice_Site		6
ABCE1	ESCA	chr4	146029243	146029243	C	T	Missense_Mutation	p.A89V	5
ABCE1	HNSC	chr4	146041093	146041093	T	-	Frame_Shift_Del	p.I311fs	5
ABCE1	STAD	chr4	146041224	146041224	A	-	Frame_Shift_Del	p.K354fs	4
ABCE1	KIRP	chr4	146041306	146041306	G	A	Splice_Site	p.G382_splice	4
ABCE1	UCEC	chr4	146048713	146048713	C	A	Missense_Mutation	p.F596L	4
ABCE1	PAAD	chr4	146032209	146032209	G	A	Missense_Mutation	p.A235T	3
ABCE1	PAAD	chr4	146044705	146044705	C	T	Silent	p.R531R	3
ABCE1	UCEC	chr4	146044712	146044712	G	A	Missense_Mutation	p.V534I	3
ABCE1	COAD	chr4	146044182	146044182	C	T	Missense_Mutation	p.R425C	3
ABCE1	PRAD	chr4	146032204	146032204	A	C	Missense_Mutation	p.Q233P	3
ABCE1	LIHC	chr4	146031543	146031543	T	-	Frame_Shift_Del	p.I187fs	3
ABCE1	SKCM	chr4	146029175	146029175	C	T	Silent	p.P66P	3
ABCE1	ESCA	chr4	146033434	146033434	C	T	Missense_Mutation	p.R252C	3
ABCE1	LIHC	chr4	146044645	146044645	A	-	Frame_Shift_Del	p.A511fs	2
ABCE1	LIHC	chr4	146029198	146029198	A	G	Missense_Mutation	p.N74S	2
ABCE1	SKCM	chr4	146042539	146042539	C	T	Missense_Mutation	p.S420L	2
ABCE1	KICH	chr4	146044440	146044440	A	G	Missense_Mutation	p.Y483C	2
ABCE1	PAAD	chr4	146032209	146032209	G	A	Missense_Mutation		2
ABCE1	STAD	chr4	146025624	146025624	A	G	Silent	p.K20K	2
ABCE1	LGG	chr4	146044497	146044497	G	A	Missense_Mutation		2
ABCE1	LIHC	chr4	146033436	146033436	T	-	Frame_Shift_Del	p.R252fs	2
ABCE1	SKCM	chr4	146032131	146032131	C	T	Silent	p.L209L	2
ABCE1	BLCA	chr4	146046206	146046206	G	A	Missense_Mutation	p.D569N	2
ABCE1	KIRC	chr4	146041212	146041212	C	A	Missense_Mutation	p.P351T	2
ABCE1	STAD	chr4	146044706	146044706	G	A	Missense_Mutation	p.V532I	2
ABCE1	LIHC	chr4	146032129	146032129	A	-	Frame_Shift_Del	p.H208fs	2
ABCE1	KIRP	chr4	146041306	146041306	G	A	Splice_Site	.	2
ABCE1	STAD	chr4	146041302	146041302	A	T	Missense_Mutation	p.N381Y	2
ABCE1	LIHC	chr4	146029198	146029198	A	G	Missense_Mutation		2
ABCE1	BLCA	chr4	146046248	146046248	A	G	Missense_Mutation	p.I583V	2
ABCE1	UCEC	chr4	146025661	146025661	C	T	Nonsense_Mutation	p.R33*	2
ABCE1	SKCM	chr4	146031258	146031258	C	T	Missense_Mutation	p.P137S	2
ABCE1	UCEC	chr4	146030400	146030400	A	T	Missense_Mutation	p.D135V	2
ABCE1	STAD	chr4	146032195	146032195	T	G	Missense_Mutation		2
ABCE1	BRCA	chr4	146038513	146038513	A	G	Missense_Mutation	p.Y290C	2
ABCE1	UCEC	chr4	146031299	146031299	T	G	Silent	p.S150	2
ABCE1	LIHC	chr4	146032133	146032133	A	-	Frame_Shift_Del	p.L209fs	2
ABCE1	STAD	chr4	146032188	146032188	G	A	Missense_Mutation		2
ABCE1	BRCA	chr4	146044454	146044454	C	G	Missense_Mutation	p.P488A	2
ABCE1	UCEC	chr4	146032180	146032180	T	G	Missense_Mutation	p.F225C	2
ABCE1	LIHC	chr4	146032184	146032184	T	-	Frame_Shift_Del	p.A226fs	2
ABCE1	SKCM	chr4	146042490	146042490	G	A	Missense_Mutation	p.V404I	2
ABCE1	STAD	chr4	146044509	146044509	G	A	Missense_Mutation		2
ABCE1	LGG	chr4	146044497	146044497	G	A	Missense_Mutation	p.R502Q	2
ABCE1	UCEC	chr4	146038505	146038505	C	T	Silent	p.C287	2
ABCE1	LIHC	chr4	146041120	146041120	A	-	Frame_Shift_Del	p.E320fs	2
ABCE1	SKCM	chr4	146044633	146044633	C	T	Silent	p.F507F	2
ABCE1	ESCA	chr4	146033434	146033434	C	T	Missense_Mutation		2
ABCE1	STAD	chr4	146032195	146032195	T	G	Missense_Mutation	p.V230G	2
ABCE1	UCEC	chr4	146041162	146041162	C	T	Missense_Mutation	p.A334V	2
ABCE1	LIHC	chr4	146042334	146042334	A	-	Frame_Shift_Del	p.K385fs	2
ABCE1	SKCM	chr4	146044254	146044254	C	T	Silent	p.L449L	2
ABCE1	ESCA	chr4	146029243	146029243	C	T	Missense_Mutation		2
ABCE1	STAD	chr4	146032188	146032188	G	A	Missense_Mutation	p.A228T	2
ABCE1	SKCM	chr4	146044718	146044718	G	A	Missense_Mutation	p.D536N	1
ABCE1	BLCA	chr4	146029185	146029185	T	C	Silent		1
ABCE1	ESCA	chr4	146044284	146044284	G	T	Splice_Site		1
ABCE1	BLCA	chr4	146031255	146031255	G	A	Splice_Site	p.D136N	1
ABCE1	KICH	chr4	146044440	146044440	A	G	Missense_Mutation		1
ABCE1	LUSC	chr4	146026771	146026771	G	C	Missense_Mutation	p.E40Q	1
ABCE1	COAD	chr4	146030343	146030343	A	T	Missense_Mutation	p.K116M	1
ABCE1	LGG	chr4	146044650	146044651	-	G	Frame_Shift_Ins	p.N513fs	1
ABCE1	LIHC	chr4	146026802	146026802	T	-	Frame_Shift_Del	p.I50fs	1
ABCE1	SKCM	chr4	146029233	146029233	C	T	Nonsense_Mutation	p.R86*	1
ABCE1	BLCA	chr4	146042527	146042527	T	G	Missense_Mutation		1
ABCE1	ESCA	chr4	146044183	146044183	G	A	Missense_Mutation	p.R425H	1
ABCE1	BLCA	chr4	146026785	146026785	G	C	Missense_Mutation	p.Q44H	1
ABCE1	COAD	chr4	146031382	146031382	A	G	Missense_Mutation	p.K178R	1
ABCE1	LIHC	chr4	146031307	146031307	A	-	Frame_Shift_Del	p.Q153fs	1
ABCE1	SKCM	chr4	146044172	146044172	G	A	Splice_Site		1
ABCE1	BLCA	chr4	146041299	146041299	G	A	Missense_Mutation		1
ABCE1	ESCA	chr4	146044284	146044284	G	T	Splice_Site	.	1
ABCE1	COAD	chr4	146041176	146041178	GAA	-	In_Frame_Del	p.338_339del	1
ABCE1	LIHC	chr4	146030326	146030326	A	T	Silent		1
ABCE1	SKCM	chr4	146029233	146029233	C	T	Nonsense_Mutation	p.R86X	1
ABCE1	LIHC	chr4	146033439	146033439	A	-	Frame_Shift_Del	p.L253fs	1
ABCE1	SKCM	chr4	146031360	146031360	C	T	Nonsense_Mutation	p.Q171*	1
ABCE1	BLCA	chr4	146031255	146031255	G	A	Missense_Mutation		1
ABCE1	HNSC	chr4	146031549	146031549	A	C	Missense_Mutation		1
ABCE1	BLCA	chr4	146038561	146038561	G	C	Missense_Mutation	p.R306T	1
ABCE1	COAD	chr4	146041199	146041199	T	C	Silent	p.C346C	1
ABCE1	LIHC	chr4	146041189	146041189	A	C	Missense_Mutation	p.K343T	1
ABCE1	SKCM	chr4	146031360	146031360	C	T	Nonsense_Mutation	p.Q171X	1
ABCE1	LIHC	chr4	146041295	146041295	G	-	Frame_Shift_Del	p.L378fs	1
ABCE1	SKCM	chr4	146046196	146046196	A	T	Silent	p.T565T	1
ABCE1	BLCA	chr4	146026785	146026785	G	C	Missense_Mutation		1
ABCE1	HNSC	chr4	146044652	146044652	A	G	Missense_Mutation		1
ABCE1	PAAD	chr4	146044705	146044705	C	T	Silent		1
ABCE1	STAD	chr4	146044509	146044509	G	A	Splice_Site	p.R506_splice	1
ABCE1	LIHC	chr4	146046219	146046219	A	C	Missense_Mutation		1
ABCE1	LIHC	chr4	146031286	146031286	A	T	Missense_Mutation	p.Y146F	1
ABCE1	LIHC	chr4	146041088	146041088	A	-	Frame_Shift_Del	p.I309fs	1
ABCE1	SKCM	chr4	146030294	146030294	C	T	Missense_Mutation	p.P100S	1
ABCE1	BLCA	chr4	146046206	146046206	G	A	Missense_Mutation		1
ABCE1	HNSC	chr4	146044652	146044652	A	G	Missense_Mutation	p.T514A	1
ABCE1	BLCA	chr4	146031388	146031388	C	A	Missense_Mutation	p.A180E	1
ABCE1	KIRP	chr4	146033407	146033407	C	G	Missense_Mutation	p.P243A	1
ABCE1	STAD	chr4	146041224	146041224	A	-	Frame_Shift_Del	p.K355fs	1
ABCE1	DLBC	chr4	146033391	146033391	T	C	Silent	p.I237I	1
ABCE1	LIHC	chr4	146029224	146029224	A	G	Missense_Mutation		1
ABCE1	SKCM	chr4	146044172	146044172	G	A	Splice_Site	.	1
ABCE1	LIHC	chr4	146041224	146041224	A	-	Frame_Shift_Del	p.K356fs	1
ABCE1	BLCA	chr4	146031587	146031587	C	A	Missense_Mutation		1
ABCE1	HNSC	chr4	146031549	146031549	A	C	Missense_Mutation	p.D189A	1
ABCE1	READ	chr4	146029234	146029234	G	A	Missense_Mutation	p.R86Q	1
ABCE1	UCEC	chr4	146032141	146032141	G	A	Missense_Mutation	p.R212Q	1
ABCE1	LIHC	chr4	146030403	146030403	T	A	Splice_Site		1
ABCE1	LUAD	chr4	146031567	146031567	A	G	Missense_Mutation	p.K195R	1
ABCE1	BLCA	chr4	146031552	146031552	G	A	Missense_Mutation		1
ABCE1	HNSC	chr4	146033465	146033465	T	C	Missense_Mutation	p.L262P	1
ABCE1	KIRP	chr4	146025567	146025567	G	T	Missense_Mutation		1
ABCE1	SARC	chr4	146041161	146041161	G	T	Missense_Mutation		1
ABCE1	LIHC	chr4	146032129	146032129	A	-	Frame_Shift_Del		1
ABCE1	LUAD	chr4	146042355	146042355	C	T	Missense_Mutation	p.L392F	1
ABCE1	BLCA	chr4	146031388	146031388	C	A	Missense_Mutation		1
ABCE1	HNSC	chr4	146033476	146033476	G	C	Missense_Mutation	p.D266H	1
ABCE1	CESC	chr4	146044714	146044714	T	T	Silent		1
ABCE1	SARC	chr4	146031349	146031349	T	A	Missense_Mutation		1
ABCE1	LUAD	chr4	146042521	146042521	A	G	Missense_Mutation	p.Q414R	1
ABCE1	BLCA	chr4	146042527	146042527	T	G	Missense_Mutation	p.I416S	1
ABCE1	COAD	chr4	146025661	146025661	C	T	Nonsense_Mutation	p.R33X	1
ABCE1	LGG	chr4	146032140	146032140	C	T	Nonsense_Mutation	p.R212*	1
ABCE1	LIHC	chr4	146030397	146030397	A	G	Missense_Mutation	p.Y134C	1
ABCE1	SARC	chr4	146031349	146031349	T	A	Missense_Mutation	p.I167N	1
ABCE1	BLCA	chr4	146041299	146041299	G	A	Missense_Mutation	p.E380K	1
ABCE1	KICH	chr4	146044692	146044692	A	G	Missense_Mutation		1
ABCE1	LUAD	chr4	146044398	146044398	G	C	Missense_Mutation	p.R469P	1
ABCE1	COAD	chr4	146030289	146030289	C	T	Missense_Mutation	p.P98L	1
ABCE1	LGG	chr4	146042358	146042358	G	A	Missense_Mutation	p.A393T	1
ABCE1	LIHC	chr4	146030345	146030345	T	C	Missense_Mutation	p.S117P	1
ABCE1	SARC	chr4	146048725	146048725	G	T	Nonstop_Mutation	p.*600Y	1

Copy number variation (CNV) of ABCE1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across ABCE1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
101665	N/A	AB062293	ABCE1	chr4	146049667	+	ATP6V1G2-DDX39B	chr6	31498118	-
98527	N/A	DA769928	ABCE1	chr4	146019571	+	ZNF827	chr4	146813584	-
103026	SARC	TCGA-DX-A3UA-01A	ACAD11	chr3	132360816	-	ABCE1	chr4	146025538	+
103026	N/A	AX396659	CLNS1A	chr11	77327200	-	ABCE1	chr4	146021145	+
103031	PRAD	TCGA-HC-7080-01A	ZNF827	chr4	146859517	-	ABCE1	chr4	146025538	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRP	ABCE1	0.00159081117211558	0.043
PAAD	ABCE1	0.0130625099959731	0.34
LUAD	ABCE1	0.0265143488970208	0.66
READ	ABCE1	0.0323733239772118	0.78
TGCT	ABCE1	2.84063684875064e-05	8e-04

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	ABCE1	0.0391349857017905	1
LAML	ABCE1	0.0202673668486546	0.67
BRCA	ABCE1	0.0209879986423746	0.67
ESCA	ABCE1	0.021387438837615	0.67

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0009402	Colorectal Carcinoma	1	CTD_human