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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL3 (NCBI Gene ID:6122)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL3
	Gene ID: 6122
	Gene Symbol	RPL3
	Gene ID	6122
	Gene Name	ribosomal protein L3
	Synonyms	ASC-1\|L3\|TARBP-B
	Cytomap	22q13.1
	Type of Gene	protein-coding
	Description	60S ribosomal protein L3HIV-1 TAR RNA-binding protein Blarge ribosomal subunit protein uL3
	Modification date	20200313
	UniProtAcc	P39023

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPL3	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPL3[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL3	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000216146	39709195	39709315	In-frame
ENST00000216146	39709638	39709734	In-frame
ENST00000216146	39710111	39710213	In-frame
ENST00000216146	39712710	39712846	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000216146	39709195	39709315	1459	1222	1341	403	349	389
ENST00000216146	39709638	39709734	1459	1126	1221	403	317	349
ENST00000216146	39710111	39710213	1459	1024	1125	403	283	317

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P39023	283	317	2	403	Chain	ID=PRO_0000077227;Note=60S ribosomal protein L3
P39023	349	389	2	403	Chain	ID=PRO_0000077227;Note=60S ribosomal protein L3
P39023	317	349	2	403	Chain	ID=PRO_0000077227;Note=60S ribosomal protein L3
P39023	283	317	286	286	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P27659
P39023	283	317	294	294	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:19608861;Dbxref=PMID:19608861
P39023	283	317	304	304	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:21406692;Dbxref=PMID:21406692
P39023	349	389	366	366	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:19608861;Dbxref=PMID:19608861
P39023	349	389	373	373	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P27659
P39023	283	317	286	286	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
P39023	283	317	294	294	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:25114211;Dbxref=PMID:25114211
P39023	349	389	366	366	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
P39023	349	389	386	386	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
STAD	RPL3	2.43523389101044	0.00016188295558095
ESCA	RPL3	1.12882976357497	0.0322265625

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
UCEC	RPL3	hsa-miR-769-5p	91	-0.376928953399542	0.0286907043625497

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
BRCA	RPL3	0.066154406	0.016031052
TGCT	RPL3	0.083376919	0.030428375

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL3 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	TSG	RPL3	GLTSCR2	0.858080959	5.01E-14
COAD	TSG	RPL3	GNB2L1	0.801411178	5.60E-75
DLBC	TSG	RPL3	GLTSCR2	0.816520671	1.50E-12
DLBC	TSG	RPL3	GNB2L1	0.838459608	1.03E-13
LAML	TSG	RPL3	GNB2L1	0.838026189	7.41E-47
LGG	Cell metabolism gene	RPL3	IMPDH2	0.829417929	1.27E-135
LGG	CGC	RPL3	NACA	0.862403939	3.13E-158
LGG	IUPHAR	RPL3	IMPDH2	0.829417929	1.27E-135
LGG	TSG	RPL3	GAS5	0.801966685	3.10E-120
LGG	TSG	RPL3	GNB2L1	0.805485702	4.55E-122
MESO	TSG	RPL3	GNB2L1	0.804882271	5.81E-21
PRAD	CGC	RPL3	NACA	0.821980514	4.31E-136
PRAD	TSG	RPL3	GNB2L1	0.893103282	2.91E-192
UVM	Cell metabolism gene	RPL3	LTA4H	0.811984051	6.37E-20
UVM	Cell metabolism gene	RPL3	POLR1D	0.829493532	2.00E-21
UVM	Cell metabolism gene	RPL3	POLR1E	0.835065414	6.14E-22
UVM	CGC	RPL3	NACA	0.896488951	2.66E-29
UVM	Epifactor	RPL3	FBL	0.812969252	5.29E-20
UVM	IUPHAR	RPL3	LTA4H	0.811984051	6.37E-20
UVM	IUPHAR	RPL3	LETMD1	0.868043778	1.97E-25
UVM	TSG	RPL3	GAS5	0.836306022	4.69E-22
UVM	TSG	RPL3	ST13	0.863291091	7.14E-25
UVM	TSG	RPL3	GNB2L1	0.865119603	4.38E-25
UVM	TSG	RPL3	GLTSCR2	0.86987072	1.19E-25

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPL3	RPL18A	-1.51651392808885	0.00016188295558095
KIRP	RPL3	RPS16	-1.35957043617517	0.00019507110118866
STAD	RPL3	RPS23	1.85076760664576	0.000364991836249828
COAD	RPL3	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPL3	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPL3	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPL3	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPL3	RPL19	1.36901182894089	0.00250792503356934
KICH	RPL3	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPL3	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPL3	RPS16	-6.16322798156577	0.0115764821363307
LUSC	RPL3	RPS23	1.46751169891047	0.0174932185880974
BLCA	RPL3	RPS12	-1.47804673440421	0.0204124450683594
HNSC	RPL3	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPL3	RPS11	1.35307548998204	0.0312207043170929
COAD	RPL3	RPS9	1.18612014402235	0.0381683111190796
LUSC	RPL3	RPL19	-2.14669889516666	0.044366810398747
UCEC	RPL3	RPS23	-2.03658159814007	0.046875
KIRC	RPL3	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPL3	RPS12	-4.91239327478244	1.85340619742495e-09
BRCA	RPL3	RPS9	1.9331477546349	2.31299392089389e-07
KIRC	RPL3	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPL3	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPL3	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPL3	RPS9	-1.32680816440987	6.53264115309597e-07
KIRC	RPL3	RPS16	-1.66149869889384	7.8509870430991e-09
KIRP	RPL3	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPL3	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPL3	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL3

PSTPIP1, SMNDC1, CNBP, LYAR, EIF6, CDC42BPB, HDAC5, NOP56, NDRG1, ARRB1, ARRB2, SIRT7, NFX1, CUL3, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, CAND1, GRK5, SMAD3, RPL10A, RPL12, RPL14, RPL15, RPL18A, RPL18, RPL19, RPL23A, RPL4, RPL5, RPL7, RPL8, RPL9, RPS16, RPS23, RPS26, RPS2, RPS3A, RPS3, RPS4X, RPS8, RPSA, RPL6, RPS15, RPL7A, RPS6, RPL21, RPS20, RPL23, RPS13, RPL10, RPS7, RPLP0, RPL11, RPL36, RPL27A, RPS15A, RPS24, RPL38, RPL17, RPL32, ILF3, NCL, TUFM, HSP90AB1, RPLP0P6, ICT1, CDH2, NENF, HSPA1L, RPL10L, HSP90AA1, PPT2, ESR1, MAGOH, EIF4A3, FN1, VCAM1, TP63, METTL18, UBL4A, SF3B1, PAN2, STXBP3, SIK1, NUMB, TARDBP, DARS, TBC1D4, rev, ZBTB1, STAU1, CEP250, NEDD1, TP53, TUBG1, TUBGCP4, HUWE1, BRCA1, CUL7, OBSL1, CCDC8, EED, RNF2, SUMO2, UBC, RAC1, EBNA1BP2, SURF2, NPM1, PRR11, RBM4B, NTRK1, EEF1A1, RNPS1, RPL13, RPL13A, RPL24, RPL26, RPL26L1, RPL28, PABPC1, RPL22, RPL27, RPL31, RPS10, RPS18, RPL30, RPL34, RPL35, RPL35A, RPL36AL, RPL37A, RPLP1, RPLP2, RPS11, RPS12, RPS14, RPS19, RPS25, LOC101929876, RPS27, RPS5, RPS9, RRP12, SEC61A1, SLC1A2, HNRNPU, Eif3a, Eif3e, Srp72, Rrbp1, Brwd3, MCM2, NF2, Mdm2, ATOH1, ZNF746, EGFR, RRS1, MAGEB10, H2AFY2, GLTSCR2, MAK16, PLEKHO1, WDR55, MECP2, ZNF2, BHLHA15, SART3, ZBTB48, KNOP1, ZNF324B, PPAN, SRP68, RBM34, KIAA0020, RRP8, CPNE4, MTNR1A, CYLD, INO80B, TRIM25, MTF1, HDAC6, CFTR, EIF4G2, LEO1, PELO, RPL3, SNAPC1, IQGAP1, RMND5A, TMPO, PPP1CC, PHLPP2, BMP4, CSNK1A1, CTNNB1, HSPA8, TRIP4, API5, COPE, DIMT1, IGFBP4, KRAS, MAP2K3, MATN2, PCBP1, PPIE, PPP6C, UBE2L6, UBE2M, TRAF6, PRPF8, EFTUD2, AAR2, PIH1D1, RNF4, CHD3, CHD4, TNF, SPDL1, RIOK1, FGF11, HEXIM1, MEPCE, LARP7, SNAI1, AGR2, RECQL4, DCPS, REST, MYC, RPS6KB2, FBL, HIST1H3A, AURKAIP1, GRWD1, METTL14, RC3H1, RC3H2, ACTC1, PHB, CREBBP, RBX1, KIN, TMEM41B, NR2C2, UBQLN2, HDAC2, OTUB2, VRK1, HIST1H4A, APEX1, ETAA1, SNRNP70, PTPN21, ITFG1, PLK1, HMGB1, BIRC3, WWP2, BRD7, MATR3, Dnajc17, SOX2, CMTR1, ARIH2, FANCD2, E7, HCVgp1, ZC3H18, MAP3K14, RAB5A, AHNAK2, HSPA5, DCUN1D5, SNIP1, ANKRD55, M, nsp13, nsp14, nsp4, nsp6, ORF3a, ORF7a, ORF7b, NEK4, DUX4, CIT, ANLN, AURKB, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, GRSF1, LRRC59, INS, NDN, BRD4, E5b, Apc2, RBM39, FBP1, MKRN1, LGALS9, IFI16, DNAJC15, DNAJC16, DNAJC1, DNAJC25, DNAJC2, KDF1, OGT, BAG5, AR, PARK2, UFL1, DDRGK1, C11orf52, CD3EAP, COIL, DHFRL1, ELOVL5, PANX1, PARP1, PDHA1, PEX3, POLR1E, RAB35, RHOB, TRIM37, SHANK3, WDR5, PAGE4, NUDCD2, NAA40, CHERP, ZNF22, DNTTIP2, FGF13, MINA, PAK1IP1, CENPC, NIP7, KAL1, NGDN, ZNF768, CENPQ, KRI1, TRMT1L, HECTD3, TTF1, TRIP12, GLE1, MRS2, RPL7L1, YBX1, RBM19, ZCCHC7, ZNF346, URB2, ZNF317, KRR1, TFB1M, ZNF184, C3orf17, MRPS7, ZZEF1, LIN28B, MRPL32, DDX21, DKC1, PRKRIR, E4F1, ZNF445, ZC3HAV1, RPL23AP32, MRPL1, ZNF189, ZNF48, WHSC1, SRPK2, ZNF512, ZNF335, PNMAL1, HIST1H2AM, ZNF629, ISG20L2, ZNF574, WDR12, MRPL16, CENPN, MYBBP1A, UTP23, TOE1, NOL8, HIST1H1C, SRSF5, NPM3, YTHDF1, SURF6, ABT1, HERC5, PPAN-P2RY11, H2AFB2, RBM5, PURB, NMNAT1, CTCF, ZNF668, H2AFB3, NOC3L, RBM28, PAPD5, PRDM15, CCDC137, LLPH, PABPC4L, DDX24, CEBPZ, DDX51, HIST1H1B, MAGEB2, DDX31, HP1BP3, MRPL28, DHX57, ZNF711, C8orf33, VPRBP, REXO4, ZNF770, CCDC140, GLYR1, GNL2, SRSF6, DDX27, REPIN1, MRPS35, MRPL18, STAU2, FTSJ3, PRKRA, MRPS9, URB1, ZC3H10, HIST1H1T, SRPK3, YTHDC2, CBX6, ADARB1, BMS1, SF3B2, AATF, BOP1, ZSCAN25, NKRF, RRP1B, SRSF1, RSL1D1, BRIX1, NVL, RSBN1, GLI4, NOP2, H1FOO, MRPS26, CENPH, EPB41L5, ZNF16, TARBP2, LIN28A, FGFBP1, RRP15, GPATCH4, MRPS18A, HIST1H2AE, WDR89, H2AFY, NOM1, PURA, C7orf50, NUPL2, CCDC59, ZBTB11, XRN1, SENP3, RNF151, DDX10, ZC3H3, NEIL1, DDX50, SPATS2L, RPF2, TAF1D, SRP14, DDX56, KMT2A, NOP16, HIST1H1E, TAF1C, GTPBP4, PINX1, ZBTB41, ZNF354A, DHX8, RRP9, ZCCHC6, DDX55, PRPF4B, TSPYL1, UTP18, HIST2H2AC, DGCR8, GTF3C2, MRPS14, BUD13, NOL10, TEX10, RRP1, NIFK, TAF1A, ZNF845, TBP, SPATS2, HIST2H2AB, MRPS17, RPS26P11, NOC2L, MRPL51, OASL, MRPL46, C14orf169, DDX54, PDCD11, WDR74, NAT10, EPB41L4B, MPHOSPH10, HIST1H1A, RPS4Y2, MAP7D1, TRIM56, SRP72, RPF1, CDKN2AIP, RSL24D1, SDAD1, GZF1, MRPS18C, POP1, HJURP, PBRM1, SRPK1, DHX30, CDC5L, SREK1, MRPL13, UTP3, GAR1, FAM111A, RAI1, IFIT5, NOP10, NSA2, IL17B, CDKN2AIPNL, DICER1, TAF1B, DDX18, C9orf114, ZFP91, PELP1, MRPL52, ZKSCAN8, ZNF771, GTPBP10, BTF3, FBXW7, EXOSC8, RBFOX2, NLRP7, APOBEC3B, RCHY1, KDM4C, CCNF, NBR1, SIRT6, RB1CC1, ZEB1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RPL3	chr22	39713638	C	CA	Duplication	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL3	chr22	39714490	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL3	KIRP	chr22	39714484	39714484	C	A	Missense_Mutation	p.K39N	4
RPL3	KIRC	chr22	39713525	39713525	G	A	Silent	p.F102F	3
RPL3	BLCA	chr22	39708981	39708981	C	T	Silent	p.L392L	3
RPL3	ESCA	chr22	39710147	39710147	C	T	Missense_Mutation	p.D306N	3
RPL3	ESCA	chr22	39714546	39714546	G	C	Missense_Mutation	p.R19G	3
RPL3	LIHC	chr22	39709288	39709288	C	A	Missense_Mutation	p.A359S	2
RPL3	ESCA	chr22	39710147	39710147	C	T	Missense_Mutation		2
RPL3	UCEC	chr22	39708972	39708972	G	C	Missense_Mutation	p.D395E	2
RPL3	ESCA	chr22	39714546	39714546	G	C	Missense_Mutation		2
RPL3	UCEC	chr22	39709298	39709298	C	T	Silent	p.T355	2
RPL3	GBM	chr22	39709294	39709294	G	A	Missense_Mutation		2
RPL3	SKCM	chr22	39712780	39712780	C	T	Silent	p.K144K	2
RPL3	UCEC	chr22	39710719	39710719	T	C	Missense_Mutation	p.Y274C	2
RPL3	HNSC	chr22	39711393	39711393	G	A	Silent		2
RPL3	SKCM	chr22	39711548	39711548	G	T	Missense_Mutation	p.P172T	2
RPL3	UCEC	chr22	39711492	39711492	C	A	Silent	p.G222C	2
RPL3	BLCA	chr22	39710727	39710727	C	T	Silent	p.Q271Q	2
RPL3	STAD	chr22	39710758	39710758	C	T	Missense_Mutation	p.R261H	2
RPL3	BLCA	chr22	39712783	39712783	C	G	Missense_Mutation	p.K143N	2
RPL3	LUAD	chr22	39713540	39713540	T	A	Silent	p.R97R	2
RPL3	STAD	chr22	39714449	39714449	G	A	Missense_Mutation	p.A51V	2
RPL3	LUAD	chr22	39709261	39709261	T	C	Missense_Mutation	p.I368V	2
RPL3	BRCA	chr22	39711522	39711522	C	G	Missense_Mutation	p.D212H	2
RPL3	BLCA	chr22	39710727	39710727	C	T	Silent		1
RPL3	HNSC	chr22	39713632	39713632	C	T	Missense_Mutation	p.V67M	1
RPL3	CESC	chr22	39709277	39709277	C	G	Missense_Mutation		1
RPL3	THYM	chr22	39714482	39714482	G	T	Missense_Mutation	p.P40Q	1
RPL3	PRAD	chr22	39712828	39712830	CTT	-	In_Frame_Del	p.K128del	1
RPL3	BLCA	chr22	39712783	39712783	C	G	Missense_Mutation		1
RPL3	HNSC	chr22	39711393	39711393	G	A	Silent	p.T223T	1
RPL3	CESC	chr22	39708974	39708974	C	T	Missense_Mutation	p.D395N	1
RPL3	LIHC	chr22	39711541	39711541	C	T	Missense_Mutation	p.R174H	1
RPL3	SARC	chr22	39714528	39714528	G	T	Missense_Mutation	p.H25N	1
RPL3	BLCA	chr22	39713471	39713471	C	T	Silent		1
RPL3	HNSC	chr22	39710765	39710766	-	A	Frame_Shift_Ins	p.C259fs	1
RPL3	CESC	chr22	39709277	39709277	C	G	Missense_Mutation	p.K362N	1
RPL3	LIHC	chr22	39711388	39711388	C	T	Missense_Mutation	p.G225D	1
RPL3	BLCA	chr22	39710205	39710205	C	T	Silent		1
RPL3	COAD	chr22	39710191	39710191	T	C	Missense_Mutation	p.Y242C	1
RPL3	LIHC	chr22	39710774	39710774	C	-	Frame_Shift_Del	p.A256fs	1
RPL3	KIRC	chr22	39710756	39710756	C	T	Missense_Mutation	p.V262I	1
RPL3	COAD	chr22	39712805	39712805	T	G	Missense_Mutation	p.K136T	1
RPL3	LUAD	chr22	39710735	39710735	C	A	Missense_Mutation	p.A269S	1
RPL3	HNSC	chr22	39713632	39713632	C	T	Missense_Mutation		1
RPL3	SKCM	chr22	39710186	39710186	T	A	Missense_Mutation	p.I244F	1
RPL3	KIRC	chr22	39711444	39711444	A	T	Silent	p.P206P	1
RPL3	COAD	chr22	39714490	39714490	C	T	Silent	p.P37P	1
RPL3	LUAD	chr22	39709669	39709669	T	A	Silent	p.G339G	1
RPL3	HNSC	chr22	39710694	39710694	C	G	Missense_Mutation		1
RPL3	SKCM	chr22	39710186	39710186	T	A	Missense_Mutation	p.I293F	1
RPL3	DLBC	chr22	39714450	39714450	C	T	Missense_Mutation	p.A51T	1
RPL3	HNSC	chr22	39710705	39710705	C	T	Missense_Mutation		1
RPL3	BLCA	chr22	39713471	39713471	C	T	Silent	p.K120K	1
RPL3	KIRP	chr22	39714484	39714484	C	A	Missense_Mutation		1
RPL3	HNSC	chr22	39710705	39710705	C	T	Missense_Mutation	p.E279K	1
RPL3	KIRP	chr22	39711372	39711372	A	C	Splice_Site		1
RPL3	STAD	chr22	39710798	39710798	G	T	Missense_Mutation	p.L248M	1
RPL3	ESCA	chr22	39712982	39712982	G	T	Missense_Mutation	p.A137D	1
RPL3	LUAD	chr22	39714471	39714472	-	G	Frame_Shift_Ins	p.S44fs	1
RPL3	BLCA	chr22	39715088	39715088	T	A	Missense_Mutation		1
RPL3	HNSC	chr22	39713611	39713611	C	A	Nonsense_Mutation	p.E74*	1
RPL3	CESC	chr22	39715539	39715539	G	A	Missense_Mutation		1
RPL3	LIHC	chr22	39709288	39709288	C	A	Missense_Mutation		1
RPL3	THCA	chr22	39710139	39710139	G	C	Missense_Mutation		1
RPL3	LUAD	chr22	39714471	39714472	-	G	Frame_Shift_Ins	p.L43fs	1
RPL3	BLCA	chr22	39708981	39708981	C	T	Silent		1
RPL3	HNSC	chr22	39710694	39710694	C	G	Missense_Mutation	p.K282N	1
RPL3	CESC	chr22	39708974	39708974	C	T	Missense_Mutation		1
RPL3	LIHC	chr22	39711388	39711388	C	T	Missense_Mutation		1
RPL3	THYM	chr22	39714482	39714482	G	T	Missense_Mutation		1
RPL3	ESCA	chr22	39708981	39708981	C	G	Silent	p.L392	1
RPL3	LUSC	chr22	39709250	39709250	G	A	Silent	p.T371T	1

Copy number variation (CNV) of RPL3
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPL3
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
101134	STAD	TCGA-HU-A4HB-01A	ASNSD1	chr2	190526336	+	RPL3	chr22	39710213	-
101134	COAD	TCGA-AA-3518-01A	C20orf96	chr20	258010	-	RPL3	chr22	39711448	-
101134	N/A	BM972994	DDHD2	chr8	38125533	+	RPL3	chr22	39713598	+
101134	Non-Cancer	ERR315333	HBB	chr11	5248198	-	RPL3	chr22	39713632	-
101134	N/A	CD699756	LPAR5	chr12	6730603	-	RPL3	chr22	39713608	-
101134	N/A	BP319563	MYH2	chr17	10428637	-	RPL3	chr22	39708939	-
101134	N/A	AW999090	NGLY1	chr3	25773848	-	RPL3	chr22	39713328	-
101134	BRCA	TCGA-E9-A22A-01A	PDGFB	chr22	39627627	-	RPL3	chr22	39714597	-
101134	KICH	TCGA-KL-8335-01A	RANGAP1	chr22	41660668	-	RPL3	chr22	39714597	-
101134	N/A	EC535704	RNASEK-C17orf49	chr17	6917789	-	RPL3	chr22	39708939	-
101134	N/A	BG505035	RPL13A	chr19	49994778	+	RPL3	chr22	39709232	-
94594	N/A	CX786698	RPL3	chr22	39711429	-	BCL2L2-PABPN1	chr14	23795153	+
103262	Non-Cancer	ERR188465	RPL3	chr22	39713565	-	EEF1A1	chr6	74228185	-
96864	N/A	BI856014	RPL3	chr22	39708889	-	HLA-B	chr6	31249349	+
102796	PRAD	TCGA-EJ-5526	RPL3	chr22	39711399	-	KLK3	chr19	51361795	+
94447	BLCA	TCGA-E7-A519-01A	RPL3	chr22	39713466	-	KRT13	chr17	39657614	-
100439	N/A	GW492822	RPL3	chr22	39708889	-	NBAS	chr2	15644841	-
83946	OV	TCGA-24-2038	RPL3	chr22	39713465	-	PLXNB1	chr3	48454578	-
100461	PRAD	TCGA-HC-7750	RPL3	chr22	39711375	-	RARA	chr17	38498827	+
101134	N/A	CF141219	RPL3	chr22	39710804	-	RPL3	chr22	39712871	-
101134	N/A	CV360980	RPL3	chr22	39715630	+	RPL3	chr22	39711466	-
99683	N/A	AW606524	RPL3	chr22	39712711	-	SDK1	chr7	4008597	-
81591	N/A	AA242792	RPL3	chr22	39711373	-	SOX8	chr16	1036443	+
103292	N/A	EC550689	RPL3	chr22	39708891	-	ZSWIM6	chr5	60686459	-
101134	N/A	CD368190	RPL38	chr17	72205334	-	RPL3	chr22	39710181	+
101134	Non-Cancer	TCGA-BH-A0E0-11A	RPS21	chr20	60962192	+	RPL3	chr22	39714529	-
101138	SKCM	TCGA-EE-A184-06A	ZFR	chr5	32444335	-	RPL3	chr22	39714597	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type	Translation factor	Coefficent	Hazard ratio	Wald test pval	Likelihool ratio pval	Logrank test pval	# samples
KIRC	RPL3	1.41654893730791	0.348223587738191	0.000131309987375931	0.000209911815335631	0.00013735703436869	604
KIRC	RPL3	1.41654893730791	0.348223587738191	0.000131309987375931	0.000209911815335631	0.00013735703436869	604
KIRP	RPL3	2.11148010515468	0.747389173209032	0.000136703633016037	0.000256745888504621	0.000121945306663436	320
KIRP	RPL3	2.11148010515468	0.747389173209032	0.000136703633016037	0.000256745888504621	0.000121945306663436	320
LGG	RPL3	0.578465724998145	-0.547375982162163	0.0001586090120355	0.000136752372500327	0.000196718693570279	525
KIRC	RPL3	1.39746983440114	0.334663340412461	0.000194009835349849	0.000235648796512346	0.000194570292096904	604
KIRC	RPL3	1.39746983440114	0.334663340412461	0.000194009835349849	0.000235648796512346	0.000194570292096904	604
KIRC	RPL3	1.25341451569148	0.225871439794097	0.000314736843003055	0.000589757779869459	0.000339766568542786	604
KIRC	RPL3	1.25341451569148	0.225871439794097	0.000314736843003055	0.000589757779869459	0.000339766568542786	604
ACC	RPL3	2.88556376334113	1.05972029277298	0.000354911312492807	0.000262014404704844	0.000257554570619207	79
LGG	RPL3	0.623125811552104	-0.473006835876344	0.00041286940860812	0.000460408899914497	0.000446122899664378	525
UVM	RPL3	0.484374140371972	-0.72489765359203	0.000470117118147972	0.000383763843349338	0.00021722011509283	80
BRCA	RPL3	0.742512239527835	-0.297715924228574	0.000490690616320664	0.000440801483093725	0.000505298367849186	1200
LGG	RPL3	0.574086806263124	-0.554974663673177	0.000517558884078563	0.000424527357748383	0.000618492780707331	525
LGG	RPL3	0.571555823662276	-0.559393121318491	0.00058599578210402	0.000470744536378747	0.000690532584085081	525
ACC	RPL3	2.37274891481352	0.864049162674452	0.000763556763744198	0.000758921527098322	0.000616712669660503	79
SARC	RPL3	1.31349972344361	0.272695119594224	0.00156658708221574	0.00218532961603345	0.00161241129708308	265
KIRC	RPL3	1.39370088489665	0.331962716069326	0.00169039399694495	0.00186606780743594	0.00167862281192009	604
KIRC	RPL3	1.39370088489665	0.331962716069326	0.00169039399694495	0.00186606780743594	0.00167862281192009	604
KIRC	RPL3	1.25097504653832	0.223923284473942	0.00255337338843496	0.00348557633613752	0.00264016556360499	604
KIRC	RPL3	1.25097504653832	0.223923284473942	0.00255337338843496	0.00348557633613752	0.00264016556360499	604
BRCA	RPL3	0.724757008179314	-0.321918841438489	0.00288066505271798	0.0023583422974905	0.00292020780338938	1200
SKCM	RPL3	1.29640730809869	0.259596829494517	0.00347718276902989	0.00856335360603202	0.00315196524853573	462
SKCM	RPL3	1.29640730809869	0.259596829494517	0.00347718276902989	0.00856335360603202	0.00315196524853573	462
KIRC	RPL3	1.30968269316696	0.269784888916795	0.00533736021807979	0.00697058823274653	0.00545537452726089	604
KIRC	RPL3	1.30968269316696	0.269784888916795	0.00533736021807979	0.00697058823274653	0.00545537452726089	604
KIRC	RPL3	1.22909576319059	0.206278747150104	0.00760654170044138	0.00862378327091527	0.00835866224919932	604
KIRC	RPL3	1.22909576319059	0.206278747150104	0.00760654170044138	0.00862378327091527	0.00835866224919932	604
BRCA	RPL3	0.785977803584385	-0.240826726666202	0.00857936067955613	0.00762683799994068	0.00868412054484381	1200
BLCA	RPL3	0.780182833668427	-0.24822698462738	0.00927075706918245	0.00750652514992645	0.00937450079019677	422
BRCA	RPL3	0.765965448871239	-0.266618216171068	0.0095560111339359	0.00923268871626383	0.00959937513785302	1200
BLCA	RPL3	0.786640893766217	-0.23998343232887	0.0115878383593295	0.0108251124595198	0.0115749829442755	422
UVM	RPL3	0.257900034729818	-1.35518323143095	0.0150255824379975	0.000905950412130388	0.00879681939976455	80
SARC	RPL3	1.38680863514253	0.327005161476875	0.0177750699558435	0.0191433388314254	0.0178095041757275	265
LUSC	RPL3	0.817649718384184	-0.201321251224779	0.0188135139872879	0.0180558138792522	0.018773501448254	545
BLCA	RPL3	0.799119757016768	-0.224244460821799	0.0194134226544906	0.0178760308491197	0.019407575405536	422
LUSC	RPL3	0.844699605244894	-0.168774211580518	0.024519165870616	0.0237680970120888	0.0245526813526749	545
LAML	RPL3	0.703022546756839	-0.352366315485435	0.0252484652665966	0.0213249362986817	0.0260668787156467	160
KIRP	RPL3	1.54876767338187	0.437459565280686	0.0256157307052789	0.0298792189144804	0.0254763990552401	320
KIRP	RPL3	1.54876767338187	0.437459565280686	0.0256157307052789	0.0298792189144804	0.0254763990552401	320
LGG	RPL3	0.684205657020603	-0.379496738392423	0.029433675021572	0.0250655573744462	0.031200900653324	525
ACC	RPL3	1.74528407615673	0.556917336763984	0.0297036974935848	0.0263273582167769	0.0287550572708701	79
UVM	RPL3	0.516205141962487	-0.66125103056458	0.0337818318492685	0.0346141397752227	0.0331230549335333	80
MESO	RPL3	0.700296472447481	-0.356251501535292	0.0338270313720984	0.0269235471842218	0.0330479543615125	85
MESO	RPL3	0.700296472447481	-0.356251501535292	0.0338270313720984	0.0269235471842218	0.0330479543615125	85
LUSC	RPL3	0.822770485765745	-0.195077992330721	0.0361768847586279	0.0349942483217621	0.0361776982923789	545
HNSC	RPL3	1.05172139692846	0.0504282474243231	0.0362083115880551	0.0387326627343116	0.0362643375345863	562
UVM	RPL3	0.52840079330127	-0.637900205007936	0.0365962936984256	0.0335487852533394	0.0352438276458231	80
BLCA	RPL3	0.802861434071358	-0.21957314023526	0.040577110359669	0.0385297090270341	0.0405811506767858	422
KIRC	RPL3	1.23339989104387	0.209774495237218	0.043194531825026	0.0448596119687372	0.043216616087392	604
KIRC	RPL3	1.23339989104387	0.209774495237218	0.043194531825026	0.0448596119687372	0.043216616087392	604
CESC	RPL3	0.775958209230017	-0.253656614334131	0.043490027901313	0.037636334814569	0.0443664908494631	295
LGG	RPL3	0.480855198712185	-0.732189096377078	4.80788900966316e-06	3.22795292863637e-06	7.23594209061998e-06	525

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	RPL3	0.00122351539173308	0.034
LIHC	RPL3	0.0182359267518051	0.49
MESO	RPL3	0.034003892455808	0.88

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPL3	0.0141533054254985	0.45
LGG	RPL3	0.00554422907006484	0.18
BRCA	RPL3	0.046690140733285	1
PAAD	RPL3	0.0369910876254309	1
UCEC	RPL3	0.0367725127371761	1
THYM	RPL3	0.0326918130035156	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
P39023	DB04865	Omacetaxine mepesuccinate	Antagonist	Small molecule	Approved\|Investigational
P39023	DB04865	Omacetaxine mepesuccinate	Antagonist

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0205696	Anaplastic carcinoma	1	CTD_human
C0205697	Carcinoma, Spindle-Cell	1	CTD_human
C0205698	Undifferentiated carcinoma	1	CTD_human
C1257925	Mammary Carcinoma, Animal	1	CTD_human