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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL4 (NCBI Gene ID:6124)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL4
	Gene ID: 6124
	Gene Symbol	RPL4
	Gene ID	6124
	Gene Name	ribosomal protein L4
	Synonyms	L4
	Cytomap	15q22.31
	Type of Gene	protein-coding
	Description	60S ribosomal protein L460S ribosomal protein L1large ribosomal subunit protein uL4
	Modification date	20200327
	UniProtAcc	P36578

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPL4	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPL4[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL4	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000307961	66792630	66792714	In-frame
ENST00000307961	66794125	66794250	Frame-shift
ENST00000307961	66795395	66795502	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000307961	66792630	66792714	2784	927	1010	427	278	305

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P36578	278	305	2	427	Chain	ID=PRO_0000129350;Note=60S ribosomal protein L4
P36578	278	305	290	290	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P50878
P36578	278	305	295	295	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18691976,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18691976,PMID:20068231,PMID:23186163
P36578	278	305	300	300	Modified residue	Note=Citrulline;Ontology_term=ECO:0000250;evidence=ECO:0000250

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
THCA	RPL4	1.38794063541307	0.00128543522995411
PRAD	RPL4	1.2589775892273	0.00136912931788367
STAD	RPL4	1.50541710129002	0.00647870777174831
BLCA	RPL4	-1.27208291287992	0.0180816650390625
KIRC	RPL4	-2.62009040507781	3.30026076039221e-08

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
BRCA	RPL4	2	1	0.0020611254072268	0.212039705882353	0.0692061719400499	-0.103842817470471	0.288157941700749

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LGG	RPL4	0.074336519	0.013775541
READ	RPL4	0.061097815	0.024210012
GBM	RPL4	0.188443772	0.028706583

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL4 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	CGC	RPL4	NACA	0.843493755	3.52E-13
CHOL	TSG	RPL4	GNB2L1	0.822969588	4.00E-12
DLBC	Cell metabolism gene	RPL4	NME2	0.809985545	3.12E-12
DLBC	CGC	RPL4	NACA	0.805638215	4.99E-12
DLBC	TF	RPL4	NME2	0.809985545	3.12E-12
DLBC	TSG	RPL4	GNB2L1	0.870997168	8.45E-16
KICH	CGC	RPL4	NACA	0.883528255	4.59E-31
LAML	TSG	RPL4	GNB2L1	0.809038092	2.56E-41
LGG	Cell metabolism gene	RPL4	IMPDH2	0.806130109	2.08E-122
LGG	CGC	RPL4	NACA	0.87263705	1.81E-166
LGG	IUPHAR	RPL4	IMPDH2	0.806130109	2.08E-122
LGG	TSG	RPL4	GNB2L1	0.808431051	1.24E-123
LGG	TSG	RPL4	GAS5	0.830114068	4.75E-136
LIHC	TSG	RPL4	GNB2L1	0.81881646	1.57E-103
MESO	CGC	RPL4	NACA	0.800950623	1.24E-20
PRAD	Cell metabolism gene	RPL4	NME2	0.805556774	1.17E-126
PRAD	Cell metabolism gene	RPL4	TIMM9	0.807161633	1.53E-127
PRAD	CGC	RPL4	NACA	0.872600014	1.14E-172
PRAD	Epifactor	RPL4	FBL	0.819790612	8.85E-135
PRAD	TF	RPL4	NME2	0.805556774	1.17E-126
PRAD	TSG	RPL4	GAS5	0.815980321	1.55E-132
PRAD	TSG	RPL4	GNB2L1	0.892456859	1.38E-191
THCA	TSG	RPL4	GAS5	0.81681445	2.75E-138
THCA	TSG	RPL4	GNB2L1	0.81945716	6.59E-140
THYM	Cell metabolism gene	RPL4	AAAS	0.800928596	1.68E-28
THYM	Cell metabolism gene	RPL4	PFDN6	0.803301377	8.85E-29
THYM	Cell metabolism gene	RPL4	SRM	0.804987477	5.57E-29
THYM	Cell metabolism gene	RPL4	PAFAH1B3	0.805351124	5.04E-29
THYM	Cell metabolism gene	RPL4	EBP	0.805521076	4.81E-29
THYM	Cell metabolism gene	RPL4	LSM5	0.805934261	4.29E-29
THYM	Cell metabolism gene	RPL4	TOMM40	0.806271619	3.91E-29
THYM	Cell metabolism gene	RPL4	ACOT8	0.806876141	3.30E-29
THYM	Cell metabolism gene	RPL4	DGUOK	0.809722921	1.48E-29
THYM	Cell metabolism gene	RPL4	SSR2	0.810483115	1.20E-29
THYM	Cell metabolism gene	RPL4	GEMIN6	0.81168847	8.47E-30
THYM	Cell metabolism gene	RPL4	PGLS	0.813989657	4.36E-30
THYM	Cell metabolism gene	RPL4	SNRPD3	0.814546386	3.71E-30
THYM	Cell metabolism gene	RPL4	LSM4	0.815995822	2.42E-30
THYM	Cell metabolism gene	RPL4	HMBS	0.816064918	2.38E-30
THYM	Cell metabolism gene	RPL4	FPGS	0.816393219	2.16E-30
THYM	Cell metabolism gene	RPL4	EXOSC5	0.817329541	1.63E-30
THYM	Cell metabolism gene	RPL4	TIMM13	0.818701512	1.09E-30
THYM	Cell metabolism gene	RPL4	SNRPF	0.823674224	2.40E-31
THYM	Cell metabolism gene	RPL4	TIMM50	0.824750303	1.72E-31
THYM	Cell metabolism gene	RPL4	SNRPD1	0.824971787	1.60E-31
THYM	Cell metabolism gene	RPL4	DGKZ	0.826463467	1.01E-31
THYM	Cell metabolism gene	RPL4	PHKG2	0.826537736	9.83E-32
THYM	Cell metabolism gene	RPL4	APRT	0.828968576	4.55E-32
THYM	Cell metabolism gene	RPL4	LSM2	0.832596381	1.41E-32
THYM	Cell metabolism gene	RPL4	SLC27A5	0.833404347	1.08E-32
THYM	Cell metabolism gene	RPL4	PFDN5	0.835747783	4.98E-33
THYM	Cell metabolism gene	RPL4	PSMC3	0.837512765	2.75E-33
THYM	Cell metabolism gene	RPL4	PSMB3	0.837846045	2.46E-33
THYM	Cell metabolism gene	RPL4	PSMD13	0.838530307	1.95E-33
THYM	Cell metabolism gene	RPL4	EXOSC1	0.838656285	1.87E-33
THYM	Cell metabolism gene	RPL4	PSMB7	0.83994312	1.20E-33
THYM	Cell metabolism gene	RPL4	SNRPD2	0.876849778	5.61E-40
THYM	Cell metabolism gene	RPL4	TIMM8B	0.886666567	5.20E-42
THYM	Cell metabolism gene	RPL4	FAU	0.90385505	4.55E-46
THYM	CGC	RPL4	SDHAF2	0.83301417	1.23E-32
THYM	Epifactor	RPL4	CCDC101	0.804437326	6.48E-29
THYM	Epifactor	RPL4	PPM1G	0.807879834	2.49E-29
THYM	Epifactor	RPL4	ZNHIT1	0.811929415	7.90E-30
THYM	Epifactor	RPL4	EXOSC5	0.817329541	1.63E-30
THYM	Epifactor	RPL4	SS18L2	0.819341813	8.97E-31
THYM	Epifactor	RPL4	CXXC1	0.834674895	7.12E-33
THYM	Epifactor	RPL4	SIRT6	0.835098787	6.18E-33
THYM	Epifactor	RPL4	RUVBL2	0.83711298	3.15E-33
THYM	Epifactor	RPL4	EXOSC1	0.838656285	1.87E-33
THYM	Epifactor	RPL4	PPP4C	0.840640489	9.47E-34
THYM	Epifactor	RPL4	NOC2L	0.850414991	2.88E-35
THYM	Epifactor	RPL4	INO80E	0.852175064	1.50E-35
THYM	Epifactor	RPL4	FBL	0.854821404	5.50E-36
THYM	Epifactor	RPL4	BRMS1	0.863650354	1.68E-37
THYM	Epifactor	RPL4	TAF10	0.901671235	1.64E-45
THYM	IUPHAR	RPL4	MFSD2B	0.803170756	9.17E-29
THYM	IUPHAR	RPL4	PHKG2	0.826537736	9.83E-32
THYM	IUPHAR	RPL4	SLC27A5	0.833404347	1.08E-32
THYM	IUPHAR	RPL4	SIRT6	0.835098787	6.18E-33
THYM	Kinase	RPL4	PHKG2	0.826537736	9.83E-32
THYM	TF	RPL4	GTF3A	0.800002447	2.16E-28
THYM	TF	RPL4	ZNF787	0.80581326	4.43E-29
THYM	TF	RPL4	ZNF668	0.808048288	2.38E-29
THYM	TF	RPL4	ZNF444	0.821119706	5.24E-31
THYM	TF	RPL4	ZNF511	0.823073984	2.88E-31
THYM	TF	RPL4	THYN1	0.823598418	2.45E-31
THYM	TF	RPL4	ZNF428	0.830765924	2.56E-32
THYM	TF	RPL4	CXXC1	0.834674895	7.12E-33
THYM	TSG	RPL4	HTRA2	0.802883588	9.91E-29
THYM	TSG	RPL4	PARK7	0.803869424	7.57E-29
THYM	TSG	RPL4	GADD45GIP1	0.805511829	4.82E-29
THYM	TSG	RPL4	PFN1	0.807023685	3.17E-29
THYM	TSG	RPL4	TSSC4	0.807182567	3.03E-29
THYM	TSG	RPL4	ZNF668	0.808048288	2.38E-29
THYM	TSG	RPL4	NPRL2	0.811186077	9.78E-30
THYM	TSG	RPL4	SIRT6	0.835098787	6.18E-33
THYM	TSG	RPL4	AIP	0.835198555	5.98E-33
THYM	TSG	RPL4	BRMS1	0.863650354	1.68E-37
THYM	TSG	RPL4	GLTSCR2	0.867054756	4.09E-38
THYM	TSG	RPL4	GNB2L1	0.872780754	3.48E-39
UCS	Cell metabolism gene	RPL4	AAAS	0.800928596	1.68E-28
UCS	Cell metabolism gene	RPL4	PFDN6	0.803301377	8.85E-29
UCS	Cell metabolism gene	RPL4	SRM	0.804987477	5.57E-29
UCS	Cell metabolism gene	RPL4	PAFAH1B3	0.805351124	5.04E-29
UCS	Cell metabolism gene	RPL4	EBP	0.805521076	4.81E-29
UCS	Cell metabolism gene	RPL4	LSM5	0.805934261	4.29E-29
UCS	Cell metabolism gene	RPL4	TOMM40	0.806271619	3.91E-29
UCS	Cell metabolism gene	RPL4	ACOT8	0.806876141	3.30E-29
UCS	Cell metabolism gene	RPL4	DGUOK	0.809722921	1.48E-29
UCS	Cell metabolism gene	RPL4	SSR2	0.810483115	1.20E-29
UCS	Cell metabolism gene	RPL4	GEMIN6	0.81168847	8.47E-30
UCS	Cell metabolism gene	RPL4	PGLS	0.813989657	4.36E-30
UCS	Cell metabolism gene	RPL4	SNRPD3	0.814546386	3.71E-30
UCS	Cell metabolism gene	RPL4	LSM4	0.815995822	2.42E-30
UCS	Cell metabolism gene	RPL4	HMBS	0.816064918	2.38E-30
UCS	Cell metabolism gene	RPL4	FPGS	0.816393219	2.16E-30
UCS	Cell metabolism gene	RPL4	EXOSC5	0.817329541	1.63E-30
UCS	Cell metabolism gene	RPL4	TIMM13	0.818701512	1.09E-30
UCS	Cell metabolism gene	RPL4	SNRPF	0.823674224	2.40E-31
UCS	Cell metabolism gene	RPL4	TIMM50	0.824750303	1.72E-31
UCS	Cell metabolism gene	RPL4	SNRPD1	0.824971787	1.60E-31
UCS	Cell metabolism gene	RPL4	DGKZ	0.826463467	1.01E-31
UCS	Cell metabolism gene	RPL4	PHKG2	0.826537736	9.83E-32
UCS	Cell metabolism gene	RPL4	APRT	0.828968576	4.55E-32
UCS	Cell metabolism gene	RPL4	LSM2	0.832596381	1.41E-32
UCS	Cell metabolism gene	RPL4	SLC27A5	0.833404347	1.08E-32
UCS	Cell metabolism gene	RPL4	PFDN5	0.835747783	4.98E-33
UCS	Cell metabolism gene	RPL4	PSMC3	0.837512765	2.75E-33
UCS	Cell metabolism gene	RPL4	PSMB3	0.837846045	2.46E-33
UCS	Cell metabolism gene	RPL4	PSMD13	0.838530307	1.95E-33
UCS	Cell metabolism gene	RPL4	EXOSC1	0.838656285	1.87E-33
UCS	Cell metabolism gene	RPL4	PSMB7	0.83994312	1.20E-33
UCS	Cell metabolism gene	RPL4	SNRPD2	0.876849778	5.61E-40
UCS	Cell metabolism gene	RPL4	TIMM8B	0.886666567	5.20E-42
UCS	Cell metabolism gene	RPL4	FAU	0.90385505	4.55E-46
UCS	CGC	RPL4	SDHAF2	0.83301417	1.23E-32
UCS	Epifactor	RPL4	CCDC101	0.804437326	6.48E-29
UCS	Epifactor	RPL4	PPM1G	0.807879834	2.49E-29
UCS	Epifactor	RPL4	ZNHIT1	0.811929415	7.90E-30
UCS	Epifactor	RPL4	EXOSC5	0.817329541	1.63E-30
UCS	Epifactor	RPL4	SS18L2	0.819341813	8.97E-31
UCS	Epifactor	RPL4	CXXC1	0.834674895	7.12E-33
UCS	Epifactor	RPL4	SIRT6	0.835098787	6.18E-33
UCS	Epifactor	RPL4	RUVBL2	0.83711298	3.15E-33
UCS	Epifactor	RPL4	EXOSC1	0.838656285	1.87E-33
UCS	Epifactor	RPL4	PPP4C	0.840640489	9.47E-34
UCS	Epifactor	RPL4	NOC2L	0.850414991	2.88E-35
UCS	Epifactor	RPL4	INO80E	0.852175064	1.50E-35
UCS	Epifactor	RPL4	FBL	0.854821404	5.50E-36
UCS	Epifactor	RPL4	BRMS1	0.863650354	1.68E-37
UCS	Epifactor	RPL4	TAF10	0.901671235	1.64E-45
UCS	IUPHAR	RPL4	MFSD2B	0.803170756	9.17E-29
UCS	IUPHAR	RPL4	PHKG2	0.826537736	9.83E-32
UCS	IUPHAR	RPL4	SLC27A5	0.833404347	1.08E-32
UCS	IUPHAR	RPL4	SIRT6	0.835098787	6.18E-33
UCS	Kinase	RPL4	PHKG2	0.826537736	9.83E-32
UCS	TF	RPL4	GTF3A	0.800002447	2.16E-28
UCS	TF	RPL4	ZNF787	0.80581326	4.43E-29
UCS	TF	RPL4	ZNF668	0.808048288	2.38E-29
UCS	TF	RPL4	ZNF444	0.821119706	5.24E-31
UCS	TF	RPL4	ZNF511	0.823073984	2.88E-31
UCS	TF	RPL4	THYN1	0.823598418	2.45E-31
UCS	TF	RPL4	ZNF428	0.830765924	2.56E-32
UCS	TF	RPL4	CXXC1	0.834674895	7.12E-33
UCS	TSG	RPL4	HTRA2	0.802883588	9.91E-29
UCS	TSG	RPL4	PARK7	0.803869424	7.57E-29
UCS	TSG	RPL4	GADD45GIP1	0.805511829	4.82E-29
UCS	TSG	RPL4	PFN1	0.807023685	3.17E-29
UCS	TSG	RPL4	TSSC4	0.807182567	3.03E-29
UCS	TSG	RPL4	ZNF668	0.808048288	2.38E-29
UCS	TSG	RPL4	NPRL2	0.811186077	9.78E-30
UCS	TSG	RPL4	SIRT6	0.835098787	6.18E-33
UCS	TSG	RPL4	AIP	0.835198555	5.98E-33
UCS	TSG	RPL4	BRMS1	0.863650354	1.68E-37
UCS	TSG	RPL4	GLTSCR2	0.867054756	4.09E-38
UCS	TSG	RPL4	GNB2L1	0.872780754	3.48E-39
UVM	Cell metabolism gene	RPL4	POLR1E	0.802632205	3.49E-19
UVM	Cell metabolism gene	RPL4	SEC11A	0.881876403	3.45E-27
UVM	CGC	RPL4	NACA	0.816404408	2.75E-20

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPL4	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPL4	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPL4	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPL4	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPL4	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPL4	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPL4	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPL4	RPL19	1.36901182894089	0.00250792503356934
KICH	RPL4	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPL4	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPL4	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPL4	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPL4	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPL4	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPL4	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPL4	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPL4	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPL4	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPL4	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPL4	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPL4	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPL4	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPL4	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPL4	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPL4	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPL4	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPL4	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPL4	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL4

MAP3K1, RRP1B, Rrp1b, MYB, HDAC5, NOP56, DYRK2, PCK1, NDRG1, ARRB2, SIRT7, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, GRK5, SMAD3, APOE, RPL21, RPL30, RPL6, RPL8, RPS11, RPS13, RPS3, RPL7, RPS3A, RPL10A, RPL7A, RPLP0, RPS9, RPL12, RPL13, RPL14, RPL15, RPL17, RPL18A, RPL18, RPL19, RPL24, RPL3, RPL5, RPL9, RPS14, RPS15A, RPS16, RPS20, RPS26, RPS2, RPS6, RPS8, RPSA, RPL23, RPS23, RPS5, RPS4X, RPLP1, RPL37A, RPL11, RPS24, RPS7, RPL23A, RPL10, RPL22, RPS17, RPS25, RPL31, RPS19, RPL27, RPS28, RPS12, RPL36, RPL32, RPL29, RPS27A, FBL, RPS21, NOP58, EEF1A1, EEF2, NCL, MYBBP1A, ILF3, ILF2, GNL3, RSL1D1, SLC25A5, EIF6, PABPC1, NHP2L1, NOLC1, RPS27L, NOP2, GNB2L1, RPLP0P6, RPL10L, NIFK, SND1, PTGES3, TUBA1C, ICT1, ATP5B, TARS, SERBP1, UQCRH, ESR1, MAGOH, EIF4A3, YWHAE, PA2G4, FN1, VCAM1, MAP1LC3A, UBL4A, ITGA4, PAN2, CD81, IGSF8, ICAM1, SORBS1, HTT, FBXO6, TARDBP, PARK2, PRPF40A, APBB1, PIN1, STAU1, CEP250, TP53, HUWE1, IL32, FUS, PHF6, RNF2, EGFR, SUMO2, NPM1, NTRK1, FTSJ3, GTPBP4, NIP7, PES1, RNPS1, RPL26, RPL26L1, RPL27A, RPL35A, RPL3L, ABCE1, BRIX1, DDX24, EEF1A2, NOC3L, RPL13A, RPL34, RPL35, RPL38, RPS10, UBA52, WDR12, RPLP2, RPS15, RPS18, LOC101929876, RPS27, SFN, XPO1, HNRNPU, TFG, Eif3a, Eif3e, Rpl35, Srp72, Ccdc77, Rrbp1, Ccdc9, Brwd3, GAN, SKI, NF2, Ksr1, RC3H1, MDM2, ATOH1, ZNF746, CNBP, RRS1, RPL28, MAGEB10, MAK16, KIAA0020, GLTSCR2, PRDM5, GPATCH4, ZNF512, PRR11, H2AFY2, SART3, RRP8, CYLD, INO80B, TRIM25, BRCA1, MTF1, LNX1, IQGAP1, HBP1, TMPO, PPP1CC, ARNT, MAP2K3, API5, BMP4, COPE, CSNK1A1, CTNNB1, GSK3A, KRAS, PCBP1, PPIE, TRIP4, UBE2M, PYHIN1, PRPF8, EFTUD2, AAR2, PIH1D1, RPTOR, RNF4, CHD3, CHD4, TNF, FAM188B, SPDL1, RIOK1, FGF11, TNPO2, MEPCE, LARP7, SNAI1, AGR2, RECQL4, REST, MYC, CDK9, RPS6KB2, GRWD1, METTL14, RC3H2, PHB, FAF1, RBX1, KIN, USP14, NR2C2, MTDH, HDAC2, VRK1, HIST1H4A, PSMD14, APEX1, SNRNP70, Dppa3, PTPN6, ITFG1, HMGB1, BIRC3, UBAP2L, NFX1, WWP2, BRD7, MATR3, SOX2, ARIH2, PLEKHA4, YAP1, TFCP2, FANCD2, HCVgp1, ZC3H18, GRB7, MAP3K14, PRKD1, IQCA1P1, CRYZ, VPS26A, MKI67, BRD3, GREB1L, SMARCAD1, SNIP1, ANKRD55, ORF14, ORF8, LRRC31, DUX4L9, DUX4, CIT, ANLN, AURKB, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, GRSF1, LRRC59, INS, NDN, MAFB, BRD4, CIC, Apc2, RBM39, FBP1, LGALS9, IFI16, EIF3H, RIN3, DNAJB6, DNAJB7, DNAJC15, DNAJC16, DNAJC19, DNAJC1, DNAJC21, DNAJC25, DNAJC28, DNAJC2, DNAJC8, DRG1, SEC63, KDF1, TRIM7, OGT, BAG5, TRIM37, UFL1, DDRGK1, DHFRL1, ELOVL5, PANX1, ATG10, SYVN1, TSC2, WDR5, PAGE4, NUDCD2, NAA40, ZNF22, DNTTIP2, TSPYL2, DDX31, H2AFX, CENPQ, PRPF4B, WDR76, DDX51, RPL36AL, YTHDC2, SRRM1, CDK13, DDX52, RNF151, GLYR1, NSD1, DKC1, ZFC3H1, DDX54, RPL7L1, SRSF1, RBM19, URB1, SRP68, SRPK2, SRPK1, C8orf33, ZNF346, ZNF629, KRR1, TRMT1L, SCAF4, C3orf17, DGCR8, BEND7, NOL8, DDX21, TBL3, PWP2, ZNF770, URB2, ITGB3BP, ZCCHC6, WDR36, GZF1, CEBPZ, GTF3C1, NAT10, CENPV, TTF1, RRP12, WDR3, PHC2, TEFM, POP1, ZC3HAV1, CENPU, TAF1C, TAF1A, U2SURP, NOC2L, SRSF5, TRIP12, HERC5, SURF6, C7orf50, NSA2, PDCD11, DHX57, MRPL52, RSBN1, ZNF317, RRP7A, NPM3, CD3EAP, CENPC, AHDC1, AATF, MPHOSPH10, CHERP, RPF1, ZNF107, GNL2, WHSC1, POLRMT, ZNF326, INO80, LENG8, RBM28, YBX1, LLPH, BBX, CTCF, CCDC137, BMS1, HIST1H1B, CENPO, NOL6, KNOP1, GTF3C2, HP1BP3, UTP23, NOL10, RBM34, CENPN, LYAR, BUD13, CCDC140, SRSF6, NGDN, VPRBP, PURB, EXOSC10, PRKRA, TEX10, ZNF189, TAF1D, ZNF638, C10orf2, ADARB1, REXO4, PATZ1, PRDM15, ZNF324, EBNA1BP2, ZNF397, ZNF48, MINA, TAF1B, TOP2A, GTPBP2, DHX30, NOP16, ZNF865, SRBD1, CDK12, NVL, RPL23AP32, MRPS24, LUC7L, NMNAT1, RSL24D1, SRP72, EPB41L4B, MRPS11, ZNF574, MRPS9, HIST1H1A, SENP3, TRIM56, MRPS31, MRPL35, ZC3H3, PAPD5, RPS4Y2, MRPL55, ZNF845, DAP3, MRPS33, MAGEB2, RPF2, HIST2H2AB, XRN1, RRP9, MRPS25, PTCD3, MRPS7, MRPS10, BOP1, MRPS26, DDX10, ZCCHC7, MRPS27, DDX50, RBM4B, DDX27, WDR74, GAR1, MRPS5, FGFBP1, SPATS2L, MRPS35, PPAN-P2RY11, LIN28A, C14orf169, ZNF668, FAM111A, HIST1H1E, NKRF, ZBTB11, NOL12, ABT1, PAK1IP1, DDX18, OASL, ZNF320, MRPS34, MRPL13, NOM1, IL17B, RRP15, KRI1, PURA, DDX56, FCF1, GTPBP10, DTX3, SPRTN, BTF3, FBXW7, RBFOX2, SF3B6, Ewsr1, RCHY1, PRDX2, CCNF, TAX1BP1, RB1CC1, DDX3X, ZEB1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RPL4	chr15	66794244	C	T	single_nucleotide_variant	Uncertain_significance	High_myopia	SO:0001583\|missense_variant	SO:0001583\|missense_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL4	PAAD	chr15	66791951	66791951	C	T	Missense_Mutation	p.A360T	5
RPL4	LUAD	chr15	66795413	66795413	G	C	Missense_Mutation	p.Q89E	5
RPL4	PAAD	chr15	66794186	66794186	C	A	Missense_Mutation	p.K162N	3
RPL4	UCEC	chr15	66792697	66792697	A	G	Missense_Mutation	p.M284T	3
RPL4	UCEC	chr15	66795458	66795458	C	T	Missense_Mutation	p.A74T	3
RPL4	BLCA	chr15	66792429	66792429	T	C	Missense_Mutation	p.M335V	3
RPL4	SKCM	chr15	66795835	66795835	G	A	Silent	p.S12S	3
RPL4	PAAD	chr15	66791951	66791951	C	T	Missense_Mutation		3
RPL4	BRCA	chr15	66794137	66794137	C	G	Missense_Mutation	p.D179H	3
RPL4	SKCM	chr15	66795836	66795836	G	A	Missense_Mutation	p.S12F	3
RPL4	BRCA	chr15	66795050	66795050	G	A	Silent	p.T107	3
RPL4	SKCM	chr15	66793834	66793834	G	A	Silent	p.A185A	2
RPL4	LUAD	chr15	66792408	66792408	G	A	Missense_Mutation	p.R342C	2
RPL4	SKCM	chr15	66792663	66792663	G	A	Silent	p.S295S	2
RPL4	LAML	chr15	64581298	64581298	C	T	Missense_Mutation	p.R143H	2
RPL4	ESCA	chr15	66791958	66791958	T	G	Silent		2
RPL4	LUAD	chr15	66792653	66792653	G	T	Missense_Mutation	p.Q299K	2
RPL4	ESCA	chr15	66791958	66791958	T	G	Silent	p.A357A	2
RPL4	BLCA	chr15	66793735	66793735	G	C	Missense_Mutation	p.I218M	2
RPL4	LUAD	chr15	66795792	66795792	C	A	Missense_Mutation	p.V27L	2
RPL4	LIHC	chr15	66795504	66795504	T	A	Splice_Site		2
RPL4	UCEC	chr15	66791860	66791860	T	G	Missense_Mutation	p.K390T	2
RPL4	SARC	chr15	66795818	66795818	G	A	Missense_Mutation		2
RPL4	UCEC	chr15	66792503	66792503	T	C	Missense_Mutation	p.H310R	2
RPL4	BLCA	chr15	66794183	66794183	C	G	Missense_Mutation	p.K163N	2
RPL4	SKCM	chr15	66794245	66794245	G	A	Missense_Mutation	p.R143C	2
RPL4	STAD	chr15	66792500	66792500	C	T	Missense_Mutation		2
RPL4	UCEC	chr15	66795005	66795005	G	A	Silent	p.Y122	2
RPL4	HNSC	chr15	66791763	66791763	C	T	Silent	p.E422E	2
RPL4	LIHC	chr15	66793810	66793810	T	-	Frame_Shift_Del	p.K193fs	2
RPL4	STAD	chr15	66795088	66795088	T	C	Missense_Mutation	p.M95V	2
RPL4	UCEC	chr15	66795844	66795844	C	T	Silent	p.S9	2
RPL4	HNSC	chr15	66795855	66795855	G	A	Missense_Mutation	p.P6S	2
RPL4	STAD	chr15	66792468	66792468	A	G	Silent	p.L322L	2
RPL4	SKCM	chr15	66794230	66794230	G	A	Missense_Mutation	p.P148S	2
RPL4	STAD	chr15	66793741	66793741	A	G	Silent	p.G216G	2
RPL4	KIRC	chr15	66795006	66795006	T	A	Missense_Mutation	p.Y122F	2
RPL4	CESC	chr15	66793301	66793301	G	C	Silent		1
RPL4	LUAD	chr15	66794968	66794968	C	G	Missense_Mutation	p.A135P	1
RPL4	STAD	chr15	66792500	66792500	C	T	Missense_Mutation	p.R311H	1
RPL4	DLBC	chr15	66791920	66791920	G	A	Missense_Mutation	p.A370V	1
RPL4	PAAD	chr15	66795082	66795082	G	T	Missense_Mutation		1
RPL4	BLCA	chr15	66795866	66795866	G	A	Missense_Mutation		1
RPL4	KIRP	chr15	66791910	66791910	G	T	Silent	p.G373G	1
RPL4	CESC	chr15	66793822	66793822	C	G	Missense_Mutation		1
RPL4	THCA	chr15	66792426	66792426	G	A	Missense_Mutation		1
RPL4	ESCA	chr15	66791958	66791958	T	G	Silent	p.A357	1
RPL4	BLCA	chr15	66794183	66794183	C	G	Missense_Mutation		1
RPL4	CESC	chr15	66795497	66795497	G	C	Missense_Mutation		1
RPL4	SKCM	chr15	66797720	66797720	G	A	Translation_Start_Site		1
RPL4	THCA	chr15	66792426	66792426	G	A	Missense_Mutation	p.R336C	1
RPL4	BLCA	chr15	66794206	66794206	C	T	Missense_Mutation		1
RPL4	LIHC	chr15	66793310	66793310	G	A	Silent		1
RPL4	CESC	chr15	66792466	66792466	C	G	Missense_Mutation		1
RPL4	SKCM	chr15	66793349	66793349	G	A	Silent	p.F257F	1
RPL4	PAAD	chr15	66793365	66793365	C	T	Nonsense_Mutation	p.W252*	1
RPL4	LIHC	chr15	66797768	66797768	A	T	Missense_Mutation		1
RPL4	CESC	chr15	66795418	66795418	G	A	Missense_Mutation		1
RPL4	SKCM	chr15	66792710	66792710	G	A	Missense_Mutation	p.P280S	1
RPL4	HNSC	chr15	66795855	66795855	G	A	Missense_Mutation		1
RPL4	READ	chr15	66793826	66793826	C	T	Missense_Mutation	p.R188Q	1
RPL4	CESC	chr15	66793822	66793822	C	G	Missense_Mutation	p.M189I	1
RPL4	LUSC	chr15	66792511	66792511	C	T	Silent	p.K307K	1
RPL4	SKCM	chr15	66793787	66793787	C	T	Missense_Mutation	p.R201H	1
RPL4	HNSC	chr15	66794123	66794123	G	A	Silent		1
RPL4	BLCA	chr15	66795866	66795866	G	A	Splice_Site	p.A2V	1
RPL4	LIHC	chr15	66795056	66795056	G	C	Silent	p.T105T	1
RPL4	SKCM	chr15	66793783	66793783	G	A	Silent	p.I202I	1
RPL4	CESC	chr15	66792466	66792466	C	G	Missense_Mutation	p.L322F	1
RPL4	LUSC	chr15	66793358	66793358	T	C	Silent	p.E254E	1
RPL4	HNSC	chr15	66793304	66793304	G	A	Silent	p.S272S	1
RPL4	SARC	chr15	66795736	66795736	G	T	Silent	p.R45R	1
RPL4	LIHC	chr15	66795504	66795504	T	A	Splice_Site	.	1
RPL4	CESC	chr15	66793301	66793301	G	C	Silent	p.L273	1
RPL4	LUSC	chr15	66793360	66793360	C	T	Missense_Mutation	p.E254K	1
RPL4	BLCA	chr15	66794206	66794206	C	T	Missense_Mutation	p.D156N	1
RPL4	CESC	chr15	66795497	66795497	G	C	Missense_Mutation	p.Q61E	1
RPL4	LIHC	chr15	66793803	66793803	T	-	Frame_Shift_Del	p.M196fs	1
RPL4	COAD	chr15	66791796	66791796	C	A	Missense_Mutation	p.K411N	1
RPL4	PAAD	chr15	66794186	66794186	C	A	Missense_Mutation		1
RPL4	UCS	chr15	66797746	66797746	C	A	Missense_Mutation		1
RPL4	BLCA	chr15	66793735	66793735	G	C	Missense_Mutation		1
RPL4	KIRC	chr15	66791809	66791809	G	A	Missense_Mutation	p.P407L	1
RPL4	LIHC	chr15	66794166	66794166	A	-	Frame_Shift_Del	p.L171fs	1
RPL4	COAD	chr15	66791814	66791814	C	A	Missense_Mutation	p.K405N	1
RPL4	PAAD	chr15	66797133	66797133	G	C	Missense_Mutation		1
RPL4	BLCA	chr15	66792429	66792429	T	C	Missense_Mutation		1

Copy number variation (CNV) of RPL4
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPL4
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
102617	COAD	TCGA-AA-3930-01A	ALDH2	chr12	112221074	+	RPL4	chr15	66791835	-
102617	N/A	BQ373207	ALG9	chr11	111692715	+	RPL4	chr15	66791990	-
102617	N/A	AA809530	ARHGAP42	chr11	100572134	+	RPL4	chr15	66791653	+
102617	LUSC	TCGA-77-7139-01A	ARID1A	chr1	27059283	+	RPL4	chr15	66792685	-
102617	LUSC	TCGA-21-1070	CLN6	chr15	68510873	-	RPL4	chr15	66791990	-
102617	N/A	CF146257	IL1RAPL1	chrX	29763580	+	RPL4	chr15	66791659	+
102617	N/A	AA493539	MAP3K13	chr3	185135481	+	RPL4	chr15	66791666	+
102617	N/A	N64049	MAP3K13	chr3	185135479	+	RPL4	chr15	66791658	+
102617	LGG	TCGA-DU-7298-01A	MEGF11	chr15	66273116	-	RPL4	chr15	66795867	-
102617	N/A	AX184577	PAXIP1	chr7	154767467	-	RPL4	chr15	66793332	-
76912	N/A	EC564499	RPL4	chr15	66795782	-	AC012501.2	chr2	154393642	+
98650	N/A	DN601711	RPL4	chr15	66794971	-	ACTN1	chr14	69347620	-
98274	Non-Cancer	43N	RPL4	chr15	66795395	-	GCA	chr2	163213267	+
101798	N/A	DA783707	RPL4	chr15	66795149	-	HS6ST3	chr13	97487488	+
98049	N/A	AV754796	RPL4	chr15	66794352	-	KRT222	chr17	38812069	-
102949	N/A	BG032278	RPL4	chr15	66791656	-	MAP3K13	chr3	185135683	-
86846	N/A	BG910912	RPL4	chr15	66795396	-	OGFOD2	chr12	123462872	+
76912	N/A	BG034633	RPL4	chr15	66791670	-	OSBP	chr11	59353208	+
93824	STAD	TCGA-HU-A4GN-01A	RPL4	chr15	66792394	-	PSMA4	chr15	78838917	+
101256	N/A	FN166485	RPL4	chr15	66790471	-	SNAPC5	chr15	66790079	-
76912	N/A	DA300676	RPL4	chr15	66795163	-	TMEM140	chr7	134832839	+
99744	N/A	BG150682	RPL4	chr15	66791658	-	TNR	chr1	175371518	-
92453	N/A	CD579733	RPL4	chr15	66793755	-	ZNF407	chr18	72623235	-
102617	N/A	AA074780	SETD5	chr3	9462539	+	RPL4	chr15	66791653	+
102617	N/A	CF135193	SMAD2	chr18	45436541	-	RPL4	chr15	66797183	-
102617	BRCA	TCGA-GI-A2C9-01A	SNAPC5	chr15	66789980	-	RPL4	chr15	66795867	-
102617	N/A	BU932269	SPCS1	chr3	52740253	+	RPL4	chr15	66795784	-
102617	N/A	BU540332	TMSB10	chr2	85133222	+	RPL4	chr15	66791786	-
102617	N/A	AK290436	TMTC3	chr12	88589368	+	RPL4	chr15	66791765	-
102622	N/A	DT218041	ZNF638	chr2	71518857	-	RPL4	chr15	66797184	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type	Translation factor	Coefficent	Hazard ratio	Wald test pval	Likelihool ratio pval	Logrank test pval	# samples
UVM	RPL4	0.3874971336359	-0.948046827284739	0.00670542164847688	0.00783410149494008	0.00548286102390029	80
LGG	RPL4	0.591762202942837	-0.524650409013029	0.00820485743775916	0.00649456813364055	0.00902254054324568	525
ACC	RPL4	1.90739275593577	0.645737260281799	0.0352393507299925	0.0322521653166061	0.0357050702847583	79
BRCA	RPL4	0.79067379798228	-0.234869788202799	0.0478015709075942	0.04714966270973	0.0479778591367147	1200
SKCM	RPL4	1.25989865045206	0.231031281579066	0.0492505159740412	0.0498170622339824	0.0492044149737652	462
SKCM	RPL4	1.25989865045206	0.231031281579066	0.0492505159740412	0.0498170622339824	0.0492044149737652	462

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	RPL4	0.000119157309003136	0.0033
TGCT	RPL4	0.00422666399108347	0.11
LUSC	RPL4	0.0215021817318291	0.56
MESO	RPL4	0.0330906471047638	0.83

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	RPL4	0.0430429506787896	1
LUSC	RPL4	0.00791663319507666	0.25
LGG	RPL4	0.0145322457585409	0.45
BRCA	RPL4	7.0421510560017e-07	2.3e-05
CHOL	RPL4	0.0225396696449111	0.68

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source