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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL6 (NCBI Gene ID:6128)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL6
	Gene ID: 6128
	Gene Symbol	RPL6
	Gene ID	6128
	Gene Name	ribosomal protein L6
	Synonyms	L6\|SHUJUN-2\|TAXREB107\|TXREB1
	Cytomap	12q24.13
	Type of Gene	protein-coding
	Description	60S ribosomal protein L6DNA-binding protein TAXREB107large ribosomal subunit protein eL6neoplasm-related protein C140tax-responsive enhancer element-binding protein 107
	Modification date	20200327
	UniProtAcc	Q02878

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPL6	GO:0002181	cytoplasmic translation	25957688

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPL6[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL6	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000202773	112846043	112846142	In-frame
ENST00000424576	112846043	112846142	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000202773	112846043	112846142	964	293	391	288	79	112
ENST00000424576	112846043	112846142	1091	424	522	288	79	112

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q02878	79	112	2	288	Chain	ID=PRO_0000171009;Note=60S ribosomal protein L6
Q02878	79	112	2	288	Chain	ID=PRO_0000171009;Note=60S ribosomal protein L6
Q02878	79	112	94	94	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P47911
Q02878	79	112	94	94	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P47911
Q02878	79	112	100	100	Natural variant	ID=VAR_036437;Note=In a colorectal cancer sample%3B somatic mutation. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q02878	79	112	100	100	Natural variant	ID=VAR_036437;Note=In a colorectal cancer sample%3B somatic mutation. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
HNSC	RPL6	2.22149016292113	0.000172794781747143
KIRP	RPL6	-1.52645217188093	7.40401446819306e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
KICH	RPL6	-0.030449573	0.022014926

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL6 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
ACC	TSG	RPL6	GNB2L1	0.804568481	4.19E-19
CESC	CGC	RPL6	NACA	0.831419423	4.43E-80
CHOL	CGC	RPL6	NACA	0.873555045	4.92E-15
CHOL	TSG	RPL6	GNB2L1	0.836173217	8.70E-13
COAD	CGC	RPL6	NACA	0.850398947	3.27E-93
DLBC	CGC	RPL6	NACA	0.906400991	7.82E-19
DLBC	Epifactor	RPL6	NAP1L1	0.801311087	7.87E-12
DLBC	TSG	RPL6	GNB2L1	0.817173626	1.39E-12
DLBC	TSG	RPL6	GAS5	0.818686346	1.17E-12
HNSC	CGC	RPL6	NACA	0.812072467	4.86E-134
KICH	CGC	RPL6	NACA	0.880163557	1.51E-30
KIRP	CGC	RPL6	NACA	0.862029663	9.57E-97
LAML	CGC	RPL6	NACA	0.827555034	9.76E-45
LGG	Cell metabolism gene	RPL6	IMPDH2	0.802339493	1.99E-120
LGG	Cell metabolism gene	RPL6	FAU	0.8026917	1.31E-120
LGG	CGC	RPL6	NACA	0.891876965	4.41E-184
LGG	IUPHAR	RPL6	IMPDH2	0.802339493	1.99E-120
LGG	TSG	RPL6	GAS5	0.8584146	3.38E-155
LGG	TSG	RPL6	GNB2L1	0.869025463	1.76E-163
LIHC	CGC	RPL6	NACA	0.854241143	1.13E-121
MESO	CGC	RPL6	NACA	0.852129544	1.26E-25
PRAD	Cell metabolism gene	RPL6	TIMM9	0.806701331	2.75E-127
PRAD	CGC	RPL6	NACA	0.891481645	1.42E-190
PRAD	TSG	RPL6	GAS5	0.841755046	7.88E-149
PRAD	TSG	RPL6	GNB2L1	0.843960477	2.33E-150
READ	CGC	RPL6	NACA	0.802468998	7.77E-25
TGCT	CGC	RPL6	NACA	0.802228107	2.53E-36
THYM	Cell metabolism gene	RPL6	AAAS	0.804489283	6.39E-29
THYM	Cell metabolism gene	RPL6	SNRPD2	0.808108414	2.34E-29
THYM	Cell metabolism gene	RPL6	SNRPD1	0.809216327	1.71E-29
THYM	Cell metabolism gene	RPL6	SLC27A5	0.817401463	1.60E-30
THYM	Cell metabolism gene	RPL6	FAU	0.823823381	2.29E-31
THYM	Cell metabolism gene	RPL6	TIMM8B	0.839297891	1.50E-33
THYM	CGC	RPL6	NACA	0.829287268	4.11E-32
THYM	Epifactor	RPL6	TAF10	0.805794875	4.46E-29
THYM	Epifactor	RPL6	FBL	0.81013888	1.32E-29
THYM	IUPHAR	RPL6	MFSD2B	0.81724558	1.68E-30
THYM	IUPHAR	RPL6	SLC27A5	0.817401463	1.60E-30
THYM	TSG	RPL6	GNB2L1	0.820347715	6.62E-31
UCEC	CGC	RPL6	NACA	0.807468411	1.70E-47
UCS	Cell metabolism gene	RPL6	AAAS	0.804489283	6.39E-29
UCS	Cell metabolism gene	RPL6	SNRPD2	0.808108414	2.34E-29
UCS	Cell metabolism gene	RPL6	SNRPD1	0.809216327	1.71E-29
UCS	Cell metabolism gene	RPL6	SLC27A5	0.817401463	1.60E-30
UCS	Cell metabolism gene	RPL6	FAU	0.823823381	2.29E-31
UCS	Cell metabolism gene	RPL6	TIMM8B	0.839297891	1.50E-33
UCS	CGC	RPL6	NACA	0.829287268	4.11E-32
UCS	Epifactor	RPL6	TAF10	0.805794875	4.46E-29
UCS	Epifactor	RPL6	FBL	0.81013888	1.32E-29
UCS	IUPHAR	RPL6	MFSD2B	0.81724558	1.68E-30
UCS	IUPHAR	RPL6	SLC27A5	0.817401463	1.60E-30
UCS	TSG	RPL6	GNB2L1	0.820347715	6.62E-31
UVM	Cell metabolism gene	RPL6	TIMM9	0.821986152	9.25E-21
UVM	CGC	RPL6	NACA	0.844715729	7.09E-23

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPL6	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPL6	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPL6	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPL6	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPL6	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPL6	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPL6	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPL6	RPL19	1.36901182894089	0.00250792503356934
KICH	RPL6	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPL6	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPL6	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPL6	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPL6	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPL6	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPL6	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPL6	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPL6	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPL6	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPL6	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPL6	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPL6	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPL6	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPL6	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPL6	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPL6	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPL6	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPL6	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPL6	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL6

NFKB2, EIF6, FGF2, SMN1, NOP56, STAU1, RAD21, ARRB1, ARRB2, SIRT7, NFX1, CUL3, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, RPL10A, RPL21, RPL30, RPL4, RPL7A, RPL7, RPS13, RPS3A, RPS3, RPS11, RPLP0, RPL8, RPS9, RPL10, RPL11, RPL12, RPL13, RPL14, RPL15, RPL17, RPL18A, RPL18, RPL19, RPL23, RPL24, RPL27A, RPL37A, RPL5, RPL9, RPS12, RPS14, RPS15A, RPS15, RPS16, RPS17, RPS19, RPS20, RPS23, RPS24, RPS25, RPS26, RPS2, RPS4X, RPS5, RPS6, RPS7, RPS8, RPSA, RPL31, RPL3, RPS28, RPL23A, RPL27, RPL22, RPL35, RPLP1, RPL36, RPL29, FBL, RPS21, RPS27A, NCL, EEF2, EEF1A1, MYBBP1A, HSP90AB1, RPL3L, DDX21, GNL3, ILF2, NOP58, SRP14, HNRNPU, ILF3, DHX9, NAP1L1, SLC25A5, NPM1, NHP2L1, TUFM, HNRNPM, NOLC1, U2AF2, EPRS, RPS27L, RPL10L, RPLP0P6, NOP2, RRS1, PRPF8, RPS10P5, MAGT1, PSIP1, CISD1, PUF60, FTSJ3, BRD4, TPR, UQCRB, PTGFRN, M6PR, ESR1, MAGOH, EIF4A3, YWHAE, VCP, FN1, CSNK2A1, IL7R, UBL4A, PAN2, CD81, IGSF8, ICAM1, IVNS1ABP, SEL1L, ND1, NPAS2, FBXO6, TARDBP, PARK2, MDM2, rev, RPA3, RPA2, RPA1, WWOX, CEP250, TP53, TUBG1, ELF3, HUWE1, CUL7, OBSL1, CCDC8, RNF2, EBNA1BP2, TRA2A, LARP7, RPL26L1, YBX1, MRPS9, NGRN, MRPS26, VPRBP, PTCD1, UPF1, PTCD3, STAU2, PABPC4, MRPS23, MRPL46, MRPS27, RRP12, KRI1, MTERF3, MRPS34, DAP3, SURF6, MRPS5, MRPS7, MRPS22, MRPL24, MRPL45, LARP1, MRPS31, LIN28B, KRR1, MRPS2, MOV10, MRPL27, MRPS11, SIRT1, CLTCL1, MRPL47, MRPS24, RALY, ZBTB11, MRPL38, MRPL15, MRPS14, MRPL13, MRPS33, MRPL9, ICT1, MRPL30, GZF1, MRPS18A, MRPL42, MRPS30, MRPS18C, SRSF10, MRPL34, MRPS21, FYTTD1, WHSC1, ABCF2, ALDH1B1, APRT, BRIX1, GTPBP4, HNRNPC, IGF2BP3, PNN, RPL32, RPL34, RPL35A, RPL38, DDX24, PABPC1, RNPS1, RPL13A, RPL26, RPS27, SRRM2, ZC3H18, RPLP2, RPS10, RPS18, LOC101929876, NTRK1, XPO1, AHSA1, THOC5, IBTK, C17orf85, CHMP4B, Cd2ap, Eif3e, Max, Mbd2, Myh9, Srp72, Tpx2, Rrbp1, Trip11, Nup98, SEC61B, LTN1, ZNF746, CDH1, EGFR, CNBP, YBX3, RPL28, MAGEB10, RBM34, SART3, MRPS35, C17orf89, CYLD, EIF2AK2, INO80B, TRIM25, BRCA1, LMNA, YAP1, VHL, FBXO7, TMPO, MTCH2, PCBP1, API5, APOE, BMP4, CCNT1, KRAS, MATN2, PPIE, TRIP4, PYHIN1, EFTUD2, AAR2, PIH1D1, CHD3, CHD4, TNF, SPDL1, RIOK1, MEPCE, PPT1, KCMF1, SNAI1, CTDSPL2, AGR2, RECQL4, GPC1, REST, MYC, CDK9, RPS6KB2, C1orf106, GRWD1, METTL14, PHB, RBX1, KIN, USP14, NR2C2, PPP1CC, MTDH, HDAC2, HIST1H2AB, HIST1H2BB, HIST1H3A, HIST1H4A, HIST1H1D, H2AFX, VRK1, TRIM3, SNRNP70, Dppa3, ITFG1, GHET1, GSK3B, ARAF, HMGB1, ABCC6, BIRC3, WWP2, BRD7, MATR3, TEX101, ARIH2, PLEKHA4, KCTD10, TFCP2, FANCD2, LINC01554, CAMK2A, GRB7, MAP3K14, NCK1, PRKAR1A, PTPN6, RAB5A, DST, TRIP12, GOT1, SVIL, SERPINA11, MACF1, SNIP1, M, nsp13, nsp4, nsp5, nsp6, ORF7a, LRRC31, DUX4, CIT, ANLN, AURKB, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, LRRC59, INS, NMRAL1, NDN, PTEN, Apc2, GLI1, RBM39, FBP1, LGALS9, GSK3A, IFI16, RIN3, DNAJB6, DNAJC15, DNAJC16, DNAJC19, DNAJC1, DNAJC21, DNAJC25, DNAJC28, DNAJC2, DNAJC8, DRG1, SETD8, NPM3, LIN28A, NAP1L5, TSPYL1, DDX58, OGT, BAG5, TRIM37, ATG5, UFL1, DDRGK1, EIF3H, CD3EAP, COIL, DHFRL1, PANX1, RAB9A, REEP5, FZR1, WDR5, PAGE4, NUDCD2, NAA40, ZBTB2, MRPL39, NOC4L, MRPL11, FHOD1, DHX8, RSL1D1, NOP14, ZNF668, SRSF5, UTP23, MRPS15, MRPL1, ZNF771, MRPL10, ZCCHC6, MECP2, LYAR, CCDC140, MRPS10, MRPL51, PRKRA, HIST1H1T, ADARB1, MRPL49, GADD45GIP1, MRPL32, H1FOO, MAGEB2, ZNF346, HIST1H1E, RBM4B, HIST1H1A, BTF3, FBXW7, NLRP7, FGD5, RCHY1, CALCOCO2, N, ZEB1,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL6	ESCA	chr12	112843140	112843140	G	T	Missense_Mutation	p.A252D	5
RPL6	LUAD	chr12	112843710	112843710	T	G	Missense_Mutation	p.K221Q	4
RPL6	KIRP	chr12	112843158	112843158	C	T	Missense_Mutation	p.R246H	4
RPL6	STAD	chr12	112846235	112846235	C	T	Missense_Mutation	p.A76T	3
RPL6	SKCM	chr12	112846062	112846062	C	T	Silent	p.V106V	2
RPL6	SKCM	chr12	112846077	112846077	G	A	Silent	p.N101N	2
RPL6	BLCA	chr12	112843711	112843711	C	T	Silent	p.K220K	2
RPL6	UCEC	chr12	112843167	112843167	G	A	Missense_Mutation	p.T243M	2
RPL6	SKCM	chr12	112843836	112843836	G	A	Silent	p.L179L	2
RPL6	UCEC	chr12	112843672	112843672	G	A	Silent	p.F233	2
RPL6	BLCA	chr12	112846122	112846122	C	G	Missense_Mutation	p.E86D	2
RPL6	UCEC	chr12	112846052	112846052	G	A	Missense_Mutation	p.R110C	2
RPL6	BRCA	chr12	112846113	112846113	G	C	Silent	p.L89	2
RPL6	HNSC	chr12	112846080	112846080	C	G	Missense_Mutation	p.K100N	2
RPL6	STAD	chr12	112843672	112843672	G	A	Silent	p.F233F	2
RPL6	CESC	chr12	112846139	112846139	C	T	Missense_Mutation	p.E81K	2
RPL6	KIRP	chr12	112843158	112843158	C	T	Missense_Mutation		2
RPL6	LAML	chr12	111330795	111330795	C	T	Missense_Mutation	p.E17K	2
RPL6	SKCM	chr12	112846061	112846061	C	T	Missense_Mutation	p.V107I	2
RPL6	CESC	chr12	112844564	112844564	C	T	Missense_Mutation	p.R156H	1
RPL6	STAD	chr12	112846375	112846375	T	C	Missense_Mutation	p.K29R	1
RPL6	LGG	chr12	112843140	112843140	G	T	Missense_Mutation		1
RPL6	BLCA	chr12	112843678	112843678	C	G	Missense_Mutation		1
RPL6	DLBC	chr12	112843105	112843105	T	C	Missense_Mutation	p.I264V	1
RPL6	STAD	chr12	112846122	112846124	CTC	-	In_Frame_Del	p.K87del	1
RPL6	LIHC	chr12	112844135	112844136	-	A	Frame_Shift_Ins	p.S164fs	1
RPL6	LIHC	chr12	112844638	112844638	T	-	Frame_Shift_Del	p.K131fs	1
RPL6	BLCA	chr12	112844607	112844607	C	T	Missense_Mutation	p.A142T	1
RPL6	ESCA	chr12	112844663	112844663	C	T	Missense_Mutation		1
RPL6	LIHC	chr12	112844660	112844660	T	-	Frame_Shift_Del	p.K124fs	1
RPL6	SKCM	chr12	112843768	112843768	G	A	Silent	p.I201I	1
RPL6	HNSC	chr12	112846080	112846080	C	G	Missense_Mutation		1
RPL6	LUAD	chr12	112844583	112844583	G	C	Missense_Mutation	p.L150V	1
RPL6	STAD	chr12	112843793	112843793	A	G	Missense_Mutation	p.F193S	1
RPL6	HNSC	chr12	112843724	112843724	T	C	Missense_Mutation		1
RPL6	CESC	chr12	112846139	112846139	C	T	Missense_Mutation		1
RPL6	HNSC	chr12	112843724	112843724	T	C	Missense_Mutation	p.Y216C	1
RPL6	LUAD	chr12	112843080	112843080	C	A	Missense_Mutation	p.R272L	1
RPL6	CESC	chr12	112844564	112844564	C	T	Missense_Mutation		1
RPL6	STAD	chr12	112846344	112846346	CTT	-	In_Frame_Del	p.39_40del	1
RPL6	LUSC	chr12	112844596	112844596	G	A	Silent	p.T145T	1
RPL6	CESC	chr12	112843702	112843702	C	T	Silent		1
RPL6	PRAD	chr12	112844588	112844588	G	T	Missense_Mutation	p.T148N	1
RPL6	STAD	chr12	112846122	112846124	CTC	-	In_Frame_Del	p.86_87del	1
RPL6	BLCA	chr12	112843711	112843711	C	T	Silent		1
RPL6	PRAD	chr12	112846078	112846078	T	C	Missense_Mutation	p.N101S	1
RPL6	CESC	chr12	112843702	112843702	C	T	Silent	p.R223	1
RPL6	STAD	chr12	112846324	112846324	C	T	Missense_Mutation	p.R46H	1
RPL6	BLCA	chr12	112846122	112846122	C	G	Missense_Mutation		1

Copy number variation (CNV) of RPL6
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPL6
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
102272	GBM	TCGA-06-0747-01A	ATXN2	chr12	112036588	-	RPL6	chr12	112849246	-
102272	Non-Cancer	ERR188441	HNRNPH1	chr5	179050038	-	RPL6	chr12	112844146	-
102272	LIHC	TCGA-BC-4073	PTPN11	chr12	112884202	+	RPL6	chr12	112843180	-
87203	N/A	BF244960	RPL6	chr12	112842998	-	AARS	chr16	70303947	-
87203	N/A	BU928941	RPL6	chr12	112842997	-	AARS	chr16	70303947	-
98653	N/A	GW493062	RPL6	chr12	112846245	+	FN1	chr2	216226310	-
93941	STAD	TCGA-D7-A74A	RPL6	chr12	112846043	-	MRPL14	chr6	44084366	-
85474	OV	TCGA-04-1365	RPL6	chr12	112844097	-	NAE1	chr16	66850575	-
102272	N/A	BG034504	RPL6	chr12	112846438	+	RPL6	chr12	112844125	-
102272	N/A	EC458219	RPL6	chr12	112843036	+	RPL6	chr12	112843809	-
76965	N/A	BG575073	RPL6	chr12	112842994	-	RPL6P27	chr18	6463003	-
76965	N/A	BI045269	RPL6	chr12	112844553	-	RPL6P27	chr18	6462994	-
102272	N/A	AA879167	RPL6P27	chr18	6462297	+	RPL6	chr12	112842994	+
102272	N/A	BG531737	TMA7	chr3	48481826	+	RPL6	chr12	112846136	-
102272	N/A	AK095760	YLPM1	chr14	75248629	+	RPL6	chr12	112843089	-
102272	N/A	AK126570	ZNF521	chr18	22839489	-	RPL6	chr12	112846249	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
BRCA	RPL6	0.0492114150005551	1
KIRC	RPL6	4.97574377320586e-05	0.0014

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
STAD	RPL6	0.00734376196446016	0.24
LUSC	RPL6	0.0018643989342612	0.062
BRCA	RPL6	0.0285576484569259	0.89
CHOL	RPL6	0.0288019116533562	0.89

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0030567	Parkinson Disease	1	CTD_human
C0205696	Anaplastic carcinoma	1	CTD_human
C0205697	Carcinoma, Spindle-Cell	1	CTD_human
C0205698	Undifferentiated carcinoma	1	CTD_human
C1257925	Mammary Carcinoma, Animal	1	CTD_human