Home

Download

Statistics

Examples

Help

Contact

	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL15 (NCBI Gene ID:6138)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL15
	Gene ID: 6138
	Gene Symbol	RPL15
	Gene ID	6138
	Gene Name	ribosomal protein L15
	Synonyms	DBA12\|EC45\|L15\|RPL10\|RPLY10\|RPYL10
	Cytomap	3p24.2
	Type of Gene	protein-coding
	Description	60S ribosomal protein L15large ribosomal subunit protein eL15
	Modification date	20200313
	UniProtAcc	P61313

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPL15	>1119.25

Top

Translation Studies in PubMed

We searched PubMed using 'RPL15[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL15	.	.

Top

Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000415719	23959023	23959156	5UTR-5UTR
ENST00000307839	23959930	23960067	Frame-shift
ENST00000354811	23959930	23960067	Frame-shift
ENST00000413699	23959930	23960067	Frame-shift
ENST00000415719	23959930	23960067	Frame-shift
ENST00000435882	23959930	23960067	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

Top

Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
ESCA	RPL15	1.76629417535644	0.0048828125

Top

Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
LGG	RPL15	2	1	0.0493293195372078	0.21429872	0.191671	-0.0760363051500793	-0.218936938483432
OV	RPL15	2	1	0.0415292530982591	0.20957037037037	0.168500869565217	0.181938061516617	0.0624165035455976

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
STAD	RPL15	-0.053834453	0.048252611

Top

Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL15 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
LGG	CGC	RPL15	NACA	0.818470164	3.56E-129
PRAD	CGC	RPL15	NACA	0.852747758	1.08E-156
PRAD	TSG	RPL15	GNB2L1	0.848268345	2.05E-153
THCA	CGC	RPL15	NACA	0.80534507	1.51E-131
THYM	Cell metabolism gene	RPL15	FAU	0.835240038	5.90E-33
THYM	IUPHAR	RPL15	SLC25A38	0.817894574	1.38E-30
UCS	Cell metabolism gene	RPL15	FAU	0.835240038	5.90E-33
UCS	IUPHAR	RPL15	SLC25A38	0.817894574	1.38E-30
UVM	Cell metabolism gene	RPL15	NMNAT3	0.821202355	1.08E-20
UVM	Cell metabolism gene	RPL15	LTA4H	0.898026642	1.53E-29
UVM	IUPHAR	RPL15	SLC25A26	0.837726735	3.43E-22
UVM	IUPHAR	RPL15	LTA4H	0.898026642	1.53E-29
UVM	TF	RPL15	NFIA	0.808866836	1.13E-19
UVM	TSG	RPL15	ST13	0.863314077	7.09E-25

Top

Protein structure

Protein 3D structure
Visit iCn3D.

Top

Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPL15	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPL15	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPL15	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPL15	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPL15	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPL15	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPL15	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPL15	RPL19	1.36901182894089	0.00250792503356934
KICH	RPL15	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPL15	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPL15	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPL15	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPL15	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPL15	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPL15	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPL15	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPL15	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPL15	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPL15	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPL15	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPL15	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPL15	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPL15	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPL15	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPL15	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPL15	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPL15	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPL15	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL15

COPS6, NOP56, STAU1, ARRB2, SIRT7, SPP1, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, DCUN1D1, CAND1, NEDD8, RPL10A, RPL11, RPL12, RPL13, RPL14, RPL18, RPL19, RPL21, RPL22, RPL23A, RPL23, RPL24, RPL27A, RPL30, RPL31, RPL37A, RPL3, RPL4, RPL5, RPL6, RPL7A, RPL7, RPL8, RPL9, RPS11, RPS14, RPS15A, RPS16, RPS20, RPS23, RPS25, RPS26, RPS28, RPS2, RPS3A, RPS3, RPS4X, RPS5, RPS6, RPS7, RPS8, RPL18A, RPS24, RPS12, RPSA, RPS19, RPS13, RPL17, RPL32, RPS27A, EEF1A1, RPS21, GNL3, FBL, SLC25A5, NCL, ILF3, EEF1D, NHP2L1, NOLC1, U2AF2, NAP1L1, TUFM, LUC7L2, U2AF1, RPS27L, GNB2L1, RPL10L, RPLP0P6, NOP2, RPS10P5, VASN, NIFK, IMPDH2, MAGOH, EIF4A3, PA2G4, FN1, IL7R, UBL4A, PAN2, ARRB1, YWHAQ, TARDBP, AIMP1, DARS, EEF1E1, IARS, QARS, EIF2S1, RPL26, RPL36, RPLP0, RPA3, RPA2, RPA1, ASB18, Fbxl16, CEP250, TP53, HUWE1, MEOX2, CUL7, OBSL1, RNF2, DHX8, ZC3H3, ZBTB38, PRR11, RBM4B, ZNF707, ILF2, ZRSR2, NTRK1, DDX24, EIF2S2, PABPC1, PABPC4, RPL10, RPL13A, RPL26L1, RPL27, RPL34, RPL35, RPL35A, RPL38, RPL3L, RPLP2, RPS10, RPS15, LOC101929876, RPS9, RPLP1, RPS18, RPS27, HNRNPU, NPM1, Eif3e, Srp72, Rrbp1, MCM2, NF2, MDM2, CDH1, COPRS, FAM192A, CLNS1A, PRMT5, VPRBP, PSME3, PWP1, KLHDC3, NLE1, ACTBL2, UBE2O, CNBP, ACTB, C1QBP, MYO18A, RIOK1, KIAA0020, RBM34, PDGFB, CUEDC1, MECP2, TARBP2, DICER1, MAGEB10, SPECC1L, GPATCH4, H2AFY2, CYLD, TRIM25, HEY1, BRCA1, YAP1, MTF1, CFTR, WDR77, KRAS, PCBP1, API5, DIMT1, PPIE, PRPF8, EFTUD2, AAR2, PIH1D1, CHD3, RNF4, CHD4, LARP7, RNF31, TNF, MEPCE, SNAI1, AGR2, RECQL4, REST, ZFP36L2, MYC, CDK9, METTL14, RC3H1, RC3H2, PHB, RBX1, NR2C2, PPP1CC, HDAC2, CTCF, ATXN3, VRK1, HIST1H4A, SNRNP70, Dppa3, ITFG1, HMGB1, PPP1CA, BIRC3, NFX1, WWP2, MATR3, CMTR1, ARIH2, PLEKHA4, WHSC1, FANCD2, NGB, ZC3H18, GRB7, MAP3K14, PRKCB, PTPN6, RAB5A, PMFBP1, MRAP, ZNF385D, M, nsp13, nsp4, nsp5, nsp6, MAP1LC3B, NEK4, DUX4, CIT, ANLN, AURKB, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, MKI67, INS, NDN, MAFB, BRD4, Apc2, RBM39, LGALS9, GSK3A, IFI16, DNAJB6, DNAJC15, DNAJC16, DNAJC19, DNAJC1, DNAJC25, DNAJC2, SETD8, TSPYL5, NPM3, KDF1, DDRGK1, PARK2, UFL1, CD3EAP, COIL, DHFRL1, DYNC1I2, LCK, MARCKS, PANX1, POLR2C, RAB35, RHOB, SYNE3, USP15, FZR1, WDR5, PAGE4, NUDCD2, NAA40, ZCCHC6, ZRANB2, SPATA5L1, NOL8, PPAN, SPATA5, ADARB1, TSPYL2, PDCD11, NVL, ZNF512, DDX21, NOL6, TTF1, LYAR, EBNA1BP2, REXO4, H2AFY, SPTY2D1, MCM10, GLI4, MAP7, EXOSC10, NSA2, NKTR, RBM5, URB2, TOPORS, PNMAL1, RRS1, H1FOO, DUSP11, ZC3HAV1, BBX, DKC1, FGF13, RRP8, DDX51, CDK12, SURF6, DDX54, ARMCX3, RSL24D1, CENPU, HERC5, URB1, DHX57, TRIM41, PIPSL, NIP7, CENPC, RNF151, TAF1B, TAF1C, FTSJ3, ZNF714, MYBBP1A, RBM19, SRSF1, BRIX1, ZNF624, TOP2A, PWP2, RPL7L1, DDX55, SDAD1, ZNF687, SRSF8, PPAN-P2RY11, U2SURP, ZNF195, GTPBP4, NOC2L, BMS1, TRMT1L, DHX36, NSMCE4A, CEBPZ, RRP12, GTF3C6, RSBN1, TSPYL1, RPF2, RBM28, ZNF692, SENP3, RPF1, TEX10, CCDC59, GTF3C2, YTHDC2, CLASP2, SRPK3, ZMYND8, PHF10, LLPH, ZSWIM8, SPHK2, PRKRA, IPO7, SRPK1, SRPK2, DNAJC13, NSUN4, DDX10, ASH1L, PURA, ZNF48, GNL2, GTF3C3, FNTA, SAP30, ZFP62, KRR1, CCDC86, RBM4, ABT1, HIST1H1E, MAGEB2, DDA1, RPL36AL, LIN28A, ZC3H10, ZNF346, ASH2L, MDM4, BTF3, FBXW7, EIF4ENIF1, RCHY1, CCNF, N,

Top

Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RPL15	chr3	23959223	A	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
RPL15	chr3	23959257	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
RPL15	chr3	23959368	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
RPL15	chr3	23959425	C	G	single_nucleotide_variant	Benign/Likely_benign	not_specified\|not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
RPL15	chr3	23959437	G	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
RPL15	chr3	23959453	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
RPL15	chr3	23959527	G	A	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Diamond-Blackfan_anemia_12\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL15	chr3	23959927	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL15	chr3	23960001	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPL15	chr3	23960032	C	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
RPL15	chr3	23960040	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPL15	chr3	23960052	T	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
RPL15	chr3	23960080	G	C	single_nucleotide_variant	Benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL15	chr3	23960155	GTGAGCTGTCTCGTATATAAAACAGGGTTTGTGATTTTTACTAATCTTGGTGAAGAGTAATTGCTTGAAAGACTTGTCTTTGTTACAAATGCGTGTGTATATACTGGAAGTACTTGTGGAACCTAAGCTTTAAAGCGGCAAGAATATGCAGAAGAGACCAAATGTGGCCTGCACAGCCTAAAATATATACTAAATATTTTTAAAGCTAAACGTTGCTGAGCTCTCAGTTGTATGGAAAAAGATAAGGTCCCCAAA	G	Deletion	Pathogenic	Diamond-Blackfan_anemia_12	SO:0001574\|splice_acceptor_variant,SO:0001575\|splice_donor_variant,SO:0001627\|intron_variant	SO:0001574\|splice_acceptor_variant,SO:0001575\|splice_donor_variant,SO:0001627\|intron_variant
RPL15	chr3	23960685	A	G	single_nucleotide_variant	Pathogenic	not_provided	SO:0001574\|splice_acceptor_variant,SO:0001627\|intron_variant	SO:0001574\|splice_acceptor_variant,SO:0001627\|intron_variant
RPL15	chr3	23960691	G	T	single_nucleotide_variant	Likely_pathogenic	Diamond-Blackfan_anemia_12	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
RPL15	chr3	23960740	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
RPL15	chr3	23960854	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
RPL15	chr3	23960863	T	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
RPL15	chr3	23960872	A	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
RPL15	chr3	23960882	C	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
RPL15	chr3	23960891	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
RPL15	chr3	23960913	A	G	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_12	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
RPL15	chr3	23960943	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
RPL15	chr3	23960956	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
RPL15	chr3	23960981	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
RPL15	chr3	23961217	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant
RPL15	chr3	23963061	GT	G	Deletion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL15	chr3	23963061	GTT	G	Deletion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL15	chr3	23963063	T	TG	Insertion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL15	chr3	23963064	T	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL15	chr3	23963065	T	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL15	chr3	23963066	T	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL15	chr3	23963067	T	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL15	chr3	23963134	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
RPL15	chr3	23963183	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL15	STAD	chr3	23959968	23959968	C	T	Silent	p.G70G	2
RPL15	UCEC	chr3	23959375	23959375	G	A	Missense_Mutation	p.E9K	2
RPL15	UCEC	chr3	23959935	23959935	C	A	Nonsense_Mutation	p.Y59*	2
RPL15	PAAD	chr3	23960714	23960715	-	T	Frame_Shift_Ins	p.L113fs	2
RPL15	UCEC	chr3	23960716	23960716	G	T	Silent	p.L113	2
RPL15	KIRC	chr3	23960059	23960059	G	T	Missense_Mutation	p.V101F	2
RPL15	BLCA	chr3	23959373	23959373	A	G	Missense_Mutation	p.Q8R	2
RPL15	PRAD	chr3	23960791	23960791	C	T	Silent	p.F138F	2
RPL15	SKCM	chr3	23960057	23960057	C	T	Missense_Mutation	p.S100F	2
RPL15	SKCM	chr3	23959495	23959495	C	G	Missense_Mutation	p.R49G	2
RPL15	GBM	chr3	23960694	23960694	C	T	Missense_Mutation		1
RPL15	LUAD	chr3	23960893	23960893	T	A	Silent	p.R172R	1
RPL15	STAD	chr3	23960861	23960861	C	T	Missense_Mutation	p.R162C	1
RPL15	GBM	chr3	23959481	23959481	G	A	Missense_Mutation		1
RPL15	LUAD	chr3	23960910	23960910	A	G	Missense_Mutation	p.H178R	1
RPL15	UCEC	chr3	23960716	23960716	G	T	Silent	p.L113L	1
RPL15	HNSC	chr3	23960061	23960061	T	A	Silent		1
RPL15	OV	chr3	23960900	23960900	G	T	Nonsense_Mutation	p.G175*	1
RPL15	HNSC	chr3	23959350	23959350	G	A	Translation_Start_Site		1
RPL15	PAAD	chr3	23960714	23960715	-	-	Frame_Shift_Ins		1
RPL15	BLCA	chr3	23959373	23959373	A	G	Missense_Mutation		1
RPL15	HNSC	chr3	23960061	23960061	T	A	Silent	p.V101V	1
RPL15	BLCA	chr3	23959451	23959451	C	T	Missense_Mutation	p.S34F	1
RPL15	PAAD	chr3	23960714	23960715	-	T	Frame_Shift_Ins	p.E113fs	1
RPL15	LGG	chr3	23960723	23960723	C	A	Missense_Mutation	p.L116M	1
RPL15	PAAD	chr3	23959499	23959499	G	C	Missense_Mutation	p.R50P	1
RPL15	BLCA	chr3	23959442	23959442	G	T	Missense_Mutation	p.R31L	1
RPL15	LIHC	chr3	23959939	23959939	A	G	Missense_Mutation		1
RPL15	ESCA	chr3	23959329	23959329	T	C	Missense_Mutation		1
RPL15	LIHC	chr3	23960001	23960001	C	T	Silent		1
RPL15	GBM	chr3	23959481	23959481	G	A	Missense_Mutation	p.R44Q	1
RPL15	LIHC	chr3	23959939	23959939	A	G	Missense_Mutation	p.I61V	1
RPL15	GBM	chr3	23959952	23959952	G	A	Missense_Mutation		1
RPL15	LIHC	chr3	23959468	23959468	C	-	Frame_Shift_Del	p.P40fs	1

Copy number variation (CNV) of RPL15
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPL15
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
103273	N/A	BE172914	APBB2	chr4	41017979	+	RPL15	chr3	23961845	+
103273	N/A	BI000195	DKC1	chrX	154005576	+	RPL15	chr3	23961220	+
103273	N/A	BG542717	HLA-DPA1	chr6	33033012	-	RPL15	chr3	23961370	+
103273	N/A	AX381522	MYO5B	chr18	47455974	-	RPL15	chr3	23961279	-
83842	N/A	BI497374	RPL15	chr3	23962334	+	AFF4	chr5	132217540	-
100090	N/A	CF124637	RPL15	chr3	23961282	+	ASCC1	chr10	73950285	+
95553	N/A	BF687895	RPL15	chr3	23961040	+	DDX46	chr5	134130922	-
89836	N/A	EC568560	RPL15	chr3	23961041	+	MYO1H	chr12	109865684	+
101389	N/A	AK130023	RPL15	chr3	23964239	+	PRKCD	chr3	53212201	+
103273	N/A	AW150992	RPL15	chr3	23962033	-	RPL15	chr3	23961791	+
103273	N/A	BE540744	RPL15	chr3	23962202	-	RPL15	chr3	23961703	+
97412	N/A	EC502070	RPL15	chr3	23960685	-	RSRC1	chr3	157993823	+
90543	N/A	AI675786	RPL15	chr3	23962037	-	TGOLN2	chr2	85554240	+
103273	N/A	AA641623	TLE3	chr15	70340954	-	RPL15	chr3	23961279	-
103273	N/A	AA173432	TULP4	chr6	158841884	+	RPL15	chr3	23962334	-
103278	COAD	TCGA-AA-3941-01A	ZSWIM4	chr19	13942623	+	RPL15	chr3	23960907	+

Top

Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

Top

Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
MESO	RPL15	0.0461478729255081	1
KIRC	RPL15	3.63654911449314e-08	1e-06

Top

Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPL15	0.011004011329871	0.34
GBM	RPL15	0.0327272928001233	0.98
LGG	RPL15	0.00298282697921881	0.098
LAML	RPL15	0.00874233993607694	0.28
BLCA	RPL15	0.0435293974447604	1

Top

Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C1260899	Anemia, Diamond-Blackfan	2	GENOMICS_ENGLAND;ORPHANET
C3809888	DIAMOND-BLACKFAN ANEMIA 12	2	CTD_human;GENOMICS_ENGLAND
C0024623	Malignant neoplasm of stomach	1	CTD_human
C0241397	Triphalangeal thumb	1	GENOMICS_ENGLAND
C1708349	Hereditary Diffuse Gastric Cancer	1	CTD_human
C2931850	Aase Smith syndrome 2	1	ORPHANET