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Translation Factor: RPL17 (NCBI Gene ID:6139) |
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 Gene Summary |
| Gene Information | Gene Name: RPL17 | Gene ID: 6139 | Gene Symbol | RPL17 | Gene ID | 6139 |
| Gene Name | ribosomal protein L17 | |
| Synonyms | L17|PD-1|RPL23 | |
| Cytomap | 18q21.1 | |
| Type of Gene | protein-coding | |
| Description | 60S ribosomal protein L1760S ribosomal protein L23gene encoding putative NFkB activating proteinlarge ribosomal subunit protein uL22 | |
| Modification date | 20200320 | |
| UniProtAcc | P18621 | |
| Child GO biological process term(s) under GO:0006412 |
| GO ID | GO term |
| GO:0005840 | Ribosome |
| GO:0002181 | Cytoplasmic translation |
| GO:0006412 | Translation |
| Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Inferred gene age of translation factor. |
| Gene | Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25 |
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| We searched PubMed using 'RPL17[title] AND translation [title] AND human.' |
| Gene | Title | PMID |
| RPL17 | . | . |
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| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. For more annotations, please visit our ExonSkipDB. |
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| Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ENST | Exon skip start (DNA) | Exon Skip end (DNA) | ORF |
| ENST00000579248 | 47017774 | 47017815 | Frame-shift |
| ENST00000579408 | 47017774 | 47017815 | Frame-shift |
| ENST00000580261 | 47017774 | 47017815 | Frame-shift |
| Exon skipping position in the amino acid sequence. |
| ENST | Exon skip start (DNA) | Exon Skip end (DNA) | Len(transcript seq) | Exon skip start (mRNA) | Exon Skip end (mRNA) | Len(amino acid seq) | Exon skip start (AA) | Exon Skip end (AA) |
| Potentially (partially) lost protein functional features of UniProt. |
| UniProtAcc | Exon skip start (AA) | Exon Skip end (AA) | Function feature start (AA) | Function feature end (AA) | Functional feature type | Functional feature desc. |
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| Gene expression level across TCGA pancancer |
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| Gene expression level across GTEx pantissue |
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| Expression level of gene isoforms across TCGA pancancer |
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| Expression level of gene isoforms across GTEx pantissue |
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| Cancer(tissue) type-specific expression level of Translation factor using z-score distriution |
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| Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples) |
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| Cancer type | Translation factor | FC | adj.pval |
| BLCA | RPL17 | -1.63321946868773 | 0.0016937255859375 |
| LUSC | RPL17 | 1.76878659669498 | 0.00310317021952006 |
| KICH | RPL17 | 2.08947044897043 | 0.0393387079238892 |
| BRCA | RPL17 | -1.41728677256105 | 4.27846131130268e-10 |
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| Translation factor expression regulation through miRNA binding |
| Cancer type | Gene | miRNA | TargetScan binding score (Context++ score percentile) | Coefficient | Pvalue |
| Translation factor expression regulation through methylation in the promoter of Translation factor |
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| Cancer type | Gene | methyl group b | methyl group a | DEG pval | avg methyl in b | avg methyl in a | avg exp in b | avg exp in a |
| Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation) |
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| Cancer type | Gene | methyl group b | methyl group a | DEG pval | avg methyl in b | avg methyl in a | avg exp in b | avg exp in a |
| Translation factor expression regulation through copy number variation of Translation factor |
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| Cancer type | Gene | Coefficient | Pvalue |
| THYM | RPL17 | 0.283071781 | 0.027062262 |
| ESCA | RPL17 | -0.055658726 | 0.031978172 |
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| Strongly correlated genes belong to cellular important gene groups with RPL17 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green) |
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| Cancer type | Gene group | Translation factor | Correlated gene | Coefficient | Pvalue |
| CHOL | CGC | RPL17 | NACA | 0.828645635 | 2.11E-12 |
| CHOL | Epifactor | RPL17 | FBL | 0.809537354 | 1.67E-11 |
| CHOL | TSG | RPL17 | GNB2L1 | 0.809272204 | 1.72E-11 |
| LGG | CGC | RPL17 | NACA | 0.806514825 | 1.30E-122 |
| LGG | TSG | RPL17 | GAS5 | 0.801102871 | 8.64E-120 |
| UVM | Epifactor | RPL17 | NAP1L1 | 0.839582664 | 2.28E-22 |
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| Protein 3D structure Visit iCn3D. |
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| Protein-protein interaction networks * Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P)) |
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| Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P)) |
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 * Edge colors based on TCGA cancer types. |
| * Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P)) |
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| Cancer type | Translation factor | Interacting protein coding gene | FC | adj.pval |
| KIRP | RPL17 | RPL18A | -1.51651392808885 | 0.00016188295558095 |
| KIRP | RPL17 | RPS16 | -1.35957043617517 | 0.00019507110118866 |
| STAD | RPL17 | RPS23 | 1.85076760664576 | 0.000364991836249828 |
| COAD | RPL17 | RPS3 | 1.48730375143014 | 0.000411599874496461 |
| COAD | RPL17 | RPL13 | 2.11745314482912 | 0.000465095043182374 |
| KIRP | RPL17 | RPS11 | -1.01861570565103 | 0.00105937570333481 |
| LIHC | RPL17 | RPL8 | -4.84588284974558 | 0.00110314154326131 |
| PRAD | RPL17 | RPL18A | 1.40600175748499 | 0.00205137828390396 |
| KICH | RPL17 | RPL19 | 1.36901182894089 | 0.00250792503356934 |
| KICH | RPL17 | RPS12 | 1.26997381758431 | 0.00308787822723389 |
| LUAD | RPL17 | RPL19 | -1.31398026615725 | 0.00993159558412698 |
| THCA | RPL17 | RPS16 | -6.16322798156577 | 0.0115764821363307 |
| LUSC | RPL17 | RPS23 | 1.46751169891047 | 0.0174932185880974 |
| BLCA | RPL17 | RPS12 | -1.47804673440421 | 0.0204124450683594 |
| HNSC | RPL17 | RPS3 | -4.73505819095135 | 0.0273726439852453 |
| STAD | RPL17 | RPL13 | -1.17078722854876 | 0.0294188209809363 |
| COAD | RPL17 | RPS11 | 1.35307548998204 | 0.0312207043170929 |
| KICH | RPL17 | RPL13 | -5.95618047175394 | 0.0366820693016052 |
| LUSC | RPL17 | RPL19 | -2.14669889516666 | 0.044366810398747 |
| UCEC | RPL17 | RPS23 | -2.03658159814007 | 0.046875 |
| KIRC | RPL17 | RPL19 | -2.73485271276676 | 1.33980982873695e-10 |
| BRCA | RPL17 | RPS12 | -4.91239327478244 | 1.85340619742495e-09 |
| KIRC | RPL17 | RPL13 | -3.44015571111292 | 2.58914497097505e-10 |
| KIRC | RPL17 | RPL35 | -1.06475238059392 | 2.72286325678163e-08 |
| KIRC | RPL17 | RPL8 | -1.18252459971773 | 5.64962994208288e-07 |
| KIRP | RPL17 | RPL8 | -1.53003692350119 | 6.0301274061203e-05 |
| KIRC | RPL17 | RPS16 | -1.66149869889384 | 7.8509870430991e-09 |
| KIRP | RPL17 | RPL35 | -1.52981101975496 | 9.0546440333128e-05 |
| KIRC | RPL17 | RPS3 | -1.29560847926387 | 9.05905681935088e-10 |
| KIRC | RPL17 | RPL18A | -4.43079304960843 | 9.2516163152192e-11 |
| Protein-protein interactors with this translation factor (BIOGRID-3.4.160) |
| PPI interactors with RPL17 |
| NOP56, EBNA-LP, NUDT3, RAD21, HDGF, NFX1, CUL3, COPS5, CAND1, RPL10A, RPL21, RPL4, RPL6, RPL7A, RPL7, RPS3A, RPS3, RPLP0, RPL11, RPL12, RPL13, RPL14, RPL15, RPL18A, RPL18, RPL19, RPL24, RPL31, RPL37A, RPL3, RPL5, RPL8, RPL9, RPS11, RPS13, RPS19, RPS20, RPS23, RPS25, RPS26, RPS28, RPS2, RPS4X, RPS5, RPS8, RPSA, RPS6, RPS24, RPL32, RPS15A, RPS16, RPL23A, RPL23, RPS27A, RPS21, RPL29, RPS12, EEF1A1, RPL22, RPL38, FBL, ILF3, ILF2, HSP90AB1, TUFM, ACTA2, EIF6, RPL10L, RPLP0P6, RPS27L, HSP90AA1, RPS10P5, HSP90AA5P, DES, ESR1, MAGOH, EIF4A3, SMURF1, VCAM1, FN1, ITGA4, RL1, PAN2, CD81, IGSF8, ICAM1, CTBP2, TARDBP, HIST1H2AB, KARS, AIMP1, OXSR1, RPL26, RPL35, RPL36, rev, STAU1, CEP76, TUBG1, RNF2, NAP1L1, RPS6KB2, AHCYL2, GFM2, MRPS7, ATP1B3, IMP3, MRPL24, MRPL4, MRPS5, PABPC1, RPL13A, RPL26L1, RPL27A, RPL35A, RPS14, RPS9, SLC1A2, RPS15, RPS18, SEC61A1, UBA52, SFN, NTRK1, HIST1H3E, AHSA1, HNRNPU, NPM1, RPL10, EXOSC1, Eif3a, Eif3e, Rpl35, Srp72, Rrbp1, Fbxo21, Ercc6l, Brwd3, MCM2, Ksr1, EGFR, C1orf131, ZC3HAV1, MAGEB10, SART3, DGCR8, RRS1, MECP2, ZNF71, ZNF2, NCL, CYLD, INO80B, TRIM25, BRCA1, YAP1, FBXO7, ADSS, HDAC4, KRAS, UBE2M, PRPF8, EFTUD2, AAR2, PIH1D1, CHD3, RNF4, CHD4, TNF, RIOK1, HEXIM1, MEPCE, LARP7, SNAI1, AGR2, RECQL4, RNF144A, REST, MYC, CDK9, GRWD1, METTL14, RC3H1, RC3H2, ACTC1, PHB, RBX1, USP14, NR2C2, PPP1CC, VRK1, VRK3, HIST1H4A, SNRNP70, PTPN6, ITFG1, ARAF, HMGB1, BIRC3, WWP2, TP53, TRIM28, ARIH2, PLEKHA4, PINK1, TFCP2, FANCD2, NHLRC2, PTEN, HCVgp1, ZC3H18, OCIAD2, HSPA5, SPTAN1, SNIP1, DUX4, CIT, ANLN, AURKB, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, LRRC59, INS, NDN, Rnf183, MAFB, BRD4, UCHL1, Apc2, RBM39, FBP1, MKRN1, LGALS9, BKRF1, DNAJC2, DNAJC8, DNAJC15, PARK2, UFL1, DDRGK1, FZR1, NAA40, TMCO1, NCLN, C7orf50, MRPL45, GADD45GIP1, TAF1D, GTPBP4, ZBTB24, YBX3, ZNF48, MRPL16, SRRM1, RBMX2, ADARB1, E4F1, GNL2, DDX21, ZNF574, RBM47, SURF6, PURA, TAF1C, TAF1B, MRPL27, MRPL32, MRPL47, MALSU1, GLI4, NKTR, PRR3, H1FOO, YTHDC2, MRPL44, THAP3, MRPL2, POP1, LYAR, SPTY2D1, MRPS33, MRPL50, PNMAL1, CNBP, ZNF445, PDCD11, RSL1D1, MINA, DHX57, FNTB, HIST1H2AM, NSA2, RNF151, DHX8, ZNF770, MTERF3, DDX50, ZC3H8, BRIX1, ZFP62, NPM3, RPF1, ZNF668, MRPS26, SRPK1, SRP72, SRP68, FGFBP1, YBX2, NGDN, H1FNT, CCDC86, NAT10, ZBTB11, RRP8, CBX6, MRPS23, RPL28, MRPL35, ZNF184, CTCF, C1QBP, DDX24, MRPL13, ZCRB1, PATZ1, UPF1, NIFK, ZNF354A, ZNF777, KRR1, LTV1, SRPK2, ZNF92, SRSF5, SRSF6, ZNF70, H2AFB3, MRPS24, ZCCHC3, GZF1, FGF17, MRPS35, NOL10, IMP4, CEBPZ, KIAA0020, MRPS30, ZNF771, LARP1, CCDC140, DDX27, NOC2L, FTSJ3, ZNF629, TOPORS, ZNF512, MRPS18C, MRPL17, MRPL18, ZCCHC17, DDX54, DAP3, PPAN-P2RY11, MRPS18B, MRPL15, MRPL9, MRPL1, SRSF3, SRSF1, LARP1B, EBNA1BP2, MRPL49, ZNF358, MRPS11, MRPS9, SRPK3, ZNF865, OTUD4, ZNF189, ZKSCAN8, RSBN1L, MRPS27, GLTSCR2, MRPL30, ZNF22, DHX30, DDX10, NVL, TTF1, MYBBP1A, PRKRA, HP1BP3, ZNF689, BMS1, UBE2O, RBM28, SCAF1, LLPH, DDX18, IL17B, WHSC1, MPHOSPH10, CCDC137, MRPL55, NOTCH2, AATF, DDX31, BOP1, MRPL51, RNH1, LIN28A, MAGEB2, RSBN1, MRPL28, UTP3, MRPL38, MRPL40, RPL7L1, REXO4, ZNF638, NOC3L, DHX36, KNOP1, YBX1, ZCCHC9, FYTTD1, NOC4L, ZBTB48, DKC1, KAL1, NOP2, RPL30, ZNF616, RBM19, PRPF4B, RPS10, MRPL46, HIST1H1A, LBR, HIST2H2AB, MRPL42, GLYR1, MRPL3, APOBEC3B, MRPL57, STAU2, PAK1IP1, NOP16, RRP12, RPL36AL, MRPL20, MRPL52, MRPS31, ABT1, MRPL39, KRI1, NEIL1, WDR74, ZNF346, MRPS25, MRPL48, PTCD3, HIST1H1E, MRPS14, MRPL23, MRPS18A, MAK16, SPRTN, BTF3, FBXW7, NLRP7, RCHY1, CCNF, CALCOCO2, N, SIRT6, RB1CC1, |
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| Clinically associated variants from ClinVar. |
| Gene | Chr | Position | RefSeq | VarSeq | RefSeeq | VarType | Pathogenic | Disease | VarInfo |
| nsSNVs with sample frequency (size of circle) from TCGA 33 cancers. |
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| SNVs and Indels |
| Gene | Cancer type | Chromosome | Start | End | RefSeeq | MutSeq | Mutation type | AAchange | # samples |
| RPL17 | BRCA | chr18 | 47015767 | 47015767 | C | T | Missense_Mutation | p.V157I | 3 |
| RPL17 | UCEC | chr18 | 47017915 | 47017915 | C | A | Missense_Mutation | p.E9D | 2 |
| RPL17 | BLCA | chr18 | 47015893 | 47015893 | C | G | Missense_Mutation | 2 | |
| RPL17 | STAD | chr18 | 47014895 | 47014895 | C | T | Silent | p.R183R | 2 |
| RPL17 | UCEC | chr18 | 47014920 | 47014920 | A | G | Missense_Mutation | p.L175P | 2 |
| RPL17 | UCEC | chr18 | 47015853 | 47015853 | C | T | Missense_Mutation | p.R128Q | 2 |
| RPL17 | UCEC | chr18 | 47015859 | 47015859 | C | T | Missense_Mutation | p.R126H | 2 |
| RPL17 | UCEC | chr18 | 47015920 | 47015920 | C | T | Missense_Mutation | p.G106S | 2 |
| RPL17 | UCEC | chr18 | 47017231 | 47017231 | C | A | Missense_Mutation | p.D50Y | 2 |
| RPL17 | SARC | chr18 | 47015764 | 47015764 | G | A | Missense_Mutation | 2 | |
| RPL17 | SKCM | chr18 | 47017254 | 47017254 | C | T | Missense_Mutation | p.R4Q | 1 |
| RPL17 | SKCM | chr18 | 47016828 | 47016828 | A | C | Missense_Mutation | p.L66R | 1 |
| RPL17 | SKCM | chr18 | 47014931 | 47014931 | G | A | Silent | p.S133S | 1 |
| RPL17 | SKCM | chr18 | 47014931 | 47014931 | G | A | Silent | p.S171S | 1 |
| RPL17 | BLCA | chr18 | 47014925 | 47014925 | C | A | Missense_Mutation | p.K173N | 1 |
| RPL17 | CESC | chr18 | 47016863 | 47016863 | C | T | Silent | 1 | |
| RPL17 | HNSC | chr18 | 47017948 | 47017948 | A | C | Missense_Mutation | 1 | |
| RPL17 | HNSC | chr18 | 47017915 | 47017915 | C | T | Silent | 1 | |
| RPL17 | LIHC | chr18 | 47016841 | 47016841 | T | C | Missense_Mutation | 1 |
| Copy number variation (CNV) of RPL17 * Click on the image to open the original image in a new window. |
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| Fusion gene breakpoints (product of the structural variants (SVs)) across RPL17 * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion genes with this translation factor from FusionGDB2.0. |
| FusionGDB2 ID | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 75993 | N/A | BG030475 | ALG14 | chr1 | 95490118 | - | RPL17 | chr18 | 47017956 | - |
| 75993 | SKCM | TCGA-EE-A29E-06A | DYM | chr18 | 46986768 | - | RPL17 | chr18 | 47017954 | - |
| 75993 | SKCM | TCGA-EE-A29E-06A | DYM | chr18 | 46986768 | - | RPL17 | chr18 | 47018922 | - |
| 75993 | N/A | AA665336 | GRIK1 | chr21 | 30946005 | - | RPL17 | chr18 | 47014854 | + |
| 75993 | LUSC | TCGA-56-6546 | NEDD4L | chr18 | 55711940 | + | RPL17 | chr18 | 47017954 | - |
| 76024 | N/A | AA876727 | RPL17 | chr18 | 47014854 | - | DHDDS | chr1 | 26781163 | - |
| 102594 | N/A | BM015160 | RPL17 | chr18 | 47014854 | - | DOCK6 | chr19 | 11371266 | + |
| 101845 | N/A | BP357702 | RPL17 | chr18 | 47015745 | - | GNA12 | chr7 | 2793677 | - |
| 101845 | N/A | BP358822 | RPL17 | chr18 | 47015743 | - | GNA12 | chr7 | 2793677 | - |
| 103339 | N/A | BI855701 | RPL17 | chr18 | 47014856 | - | PIGK | chr1 | 77594789 | + |
| 99016 | N/A | BG032231 | RPL17 | chr18 | 47014857 | - | THSD4 | chr15 | 71633497 | - |
| 75993 | N/A | AA720925 | RPL17-C18orf32 | chr18 | 47014936 | + | RPL17 | chr18 | 47014854 | + |
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| Kaplan-Meier plots with logrank tests of overall survival (OS) |
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| Cancer type | Translation factor | Coefficent | Hazard ratio | Wald test pval | Likelihool ratio pval | Logrank test pval | # samples |
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| Differential gene expression between female and male. (Wilcoxon test, pval<0.05) |
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| Cancer type | Translation factor | pval | adj.p |
| KIRC | RPL17 | 0.00698613135677524 | 0.2 |
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| Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05) |
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| Cancer type | Translation factor | pval | adj.p |
| LIHC | RPL17 | 0.0314256370539198 | 0.97 |
| LGG | RPL17 | 8.96926401287455e-05 | 0.003 |
| LAML | RPL17 | 0.033925525335476 | 1 |
| BRCA | RPL17 | 0.0117844249598086 | 0.38 |
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| Drugs targeting genes involved in this translation factor. (DrugBank Version 5.1.8 2021-05-08) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| Diseases associated with this translation factor. (DisGeNet 4.0) |
| Disease ID | Disease Name | # PubMeds | Disease source |
| C0151744 | Myocardial Ischemia | 1 | CTD_human |
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