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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL22 (NCBI Gene ID:6146)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL22
	Gene ID: 6146
	Gene Symbol	RPL22
	Gene ID	6146
	Gene Name	ribosomal protein L22
	Synonyms	EAP\|HBP15\|HBP15/L22\|L22
	Cytomap	1p36.31
	Type of Gene	protein-coding
	Description	60S ribosomal protein L22EBER-associated proteinEpstein-Barr virus small RNA-associated proteinEpstein-Barr-encoded RNA-associated proteinheparin-binding protein 15heparin-binding protein HBp15large ribosomal subunit protein eL22
	Modification date	20200313
	UniProtAcc	P35268

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPL22	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPL22[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL22	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000234875	6252989	6253114	Frame-shift
ENST00000234875	6257711	6257816	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000234875	6257711	6257816	2095	52	156	128	4	39

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P35268	4	39	2	128	Chain	ID=PRO_0000215501;Note=60S ribosomal protein L22

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LIHC	RPL22	1.69944741480638	0.00235963995691637
BLCA	RPL22	-1.66398106452175	0.002838134765625
UCEC	RPL22	-1.25950871113125	0.046875
BRCA	RPL22	-2.59980502511221	6.9057331042677e-19
KIRP	RPL22	1.74965489233405	7.71600753068924e-06

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
BLCA	RPL22	2	1	0.0258770629874811	0.211087414965986	0.166966753246753	-0.273103727136922	-0.113176788361561
READ	RPL22	2	1	0.0266890470412189	0.218915454545455	0.1818485	-0.13873276238759	-0.311428216932983

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
UVM	RPL22	-0.190575418	0.000919024
CESC	RPL22	0.086158015	0.000999362
LAML	RPL22	0.038052073	0.009563394

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL22 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	RPL22	PFDN5	0.800257925	8.78E-12
DLBC	Cell metabolism gene	RPL22	POLR2F	0.811907856	2.52E-12
DLBC	Cell metabolism gene	RPL22	NME2	0.816850014	1.45E-12
DLBC	Cell metabolism gene	RPL22	FAU	0.852774639	1.44E-14
DLBC	Cell metabolism gene	RPL22	SNRPD2	0.867290766	1.55E-15
DLBC	CGC	RPL22	NACA	0.8212201	8.73E-13
DLBC	Epifactor	RPL22	FBL	0.86725766	1.56E-15
DLBC	TF	RPL22	NME2	0.816850014	1.45E-12
DLBC	TSG	RPL22	PARK7	0.809707037	3.21E-12
DLBC	TSG	RPL22	GNB2L1	0.819226932	1.10E-12
LAML	Cell metabolism gene	RPL22	TIMM9	0.828475505	6.44E-45
PRAD	CGC	RPL22	NACA	0.817019476	3.83E-133
THYM	Cell metabolism gene	RPL22	PFDN5	0.803425695	8.55E-29
THYM	Cell metabolism gene	RPL22	FAU	0.845114189	1.97E-34
THYM	Epifactor	RPL22	DMAP1	0.804214307	6.89E-29
THYM	IUPHAR	RPL22	CSNK2B	0.801811792	1.33E-28
THYM	TSG	RPL22	GLTSCR2	0.825022951	1.58E-31
THYM	TSG	RPL22	GNB2L1	0.830081562	3.19E-32
UCS	Cell metabolism gene	RPL22	PFDN5	0.803425695	8.55E-29
UCS	Cell metabolism gene	RPL22	FAU	0.845114189	1.97E-34
UCS	Epifactor	RPL22	DMAP1	0.804214307	6.89E-29
UCS	IUPHAR	RPL22	CSNK2B	0.801811792	1.33E-28
UCS	TSG	RPL22	GLTSCR2	0.825022951	1.58E-31
UCS	TSG	RPL22	GNB2L1	0.830081562	3.19E-32
UVM	Cell metabolism gene	RPL22	SEC11A	0.802711621	3.44E-19

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPL22	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPL22	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPL22	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPL22	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPL22	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPL22	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPL22	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPL22	RPL19	1.36901182894089	0.00250792503356934
KICH	RPL22	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPL22	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPL22	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPL22	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPL22	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPL22	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPL22	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPL22	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPL22	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPL22	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPL22	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPL22	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPL22	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPL22	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPL22	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPL22	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPL22	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPL22	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPL22	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPL22	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL22

NSFL1C, CSE1L, CDC42, UBC, POU5F1, CD4, CALM1, EBNA-LP, MAPK14, RAD21, HDGF, ARRB1, ARRB2, NFX1, CUL3, CUL4A, CUL5, CUL2, CDK2, CUL1, COPS5, CAND1, PRAME, RPL15, RPL18, RPL19, RPL24, RPL37A, RPL14, RPS23, RPL11, RPL13, RPL4, RPS11, RPS13, RPS8, RPL6, RPL21, RPL27A, RPL5, RPL23A, RPS16, RPL7, RPL18A, RPS3A, RPL30, RPS26, RPS4X, RPS3, RPL7A, RPS6, RPS2, RPLP0, RPSA, RPS17, RPS24, RPS19, RPL23, RPL31, RPL12, RPL10A, RPS27A, RPS21, RPL17, ILF3, HNRNPM, RPS27L, RPL10L, STRAP, RPLP0P6, HSP90AA4P, DHX15, ESR1, SMURF1, VCAM1, FN1, IL7R, UBL4A, ITGA4, PAN2, CD81, IGSF8, ICAM1, SRPK2, TARDBP, PARK2, ARFGAP1, GTF3C4, HEXB, AURKA, CEP57, CEP76, TUBG1, VCP, HUWE1, PHF6, CCDC8, EED, RNF2, EGFR, LUZP4, WDR76, HNRNPU, LUC7L2, RPL10, RPL13A, ATP1B3, RPL38, RPL8, RPS12, RPS20, RPS5, RPL26, RPL26L1, RPL27, RPL3, RPL34, RPL35, RPL35A, RPL36, RPL9, RPLP2, RPS10, RPS14, RPS15, RPS15A, RPS18, RPS25, LOC101929876, RPS27, RPS7, RPS9, AHSA1, MYH9, NPM1, THOC5, NOP56, CBX8, Actb, Eif3a, Eif3e, Ktn1, Coro1c, Rpl35, Srp72, Rrbp1, Ccdc9, Flnb, MCM2, Ksr1, RC3H1, CDC73, NCL, CYLD, TRIM25, BMP4, PRPF8, PIH1D1, EFTUD2, CHD3, CHD4, TNF, SDCBP, SDCBP2, BAG4, FAM188B, MDM2, SPDL1, RIOK1, HEXIM1, MEPCE, LARP7, PPT1, HERC2, UBE3A, AGR2, RECQL4, REST, ZFP36L2, MYC, Prkab1, GRWD1, METTL14, KIAA1429, PSME3, EIF4B, RC3H2, PHB, RBX1, USP14, NR2C2, PPP1CC, AGRN, KRAS, DYNLT1, VRK1, HIST1H4A, SNRNP70, Dppa3, ITFG1, ARAF, HMGB1, BIRC3, STAU1, WWP2, RPL22, THAP1, DDIT4L, SURF6, ZCCHC10, AP2M1, FGF11, BEND7, STAC3, HIST1H2BN, CT45A1, ARIH2, PLEKHA4, PINK1, FANCD2, PTEN, HCVgp1, ZC3H18, FGFR1, HCK, MAPK1, PTPN6, H1FOO, M, nsp13, nsp4, nsp6, ORF3a, NEK4, DUX4, CIT, ANLN, AURKB, CHMP4B, ECT2, KIF14, KIF20A, KIF23, PRC1, INS, NINL, Apc2, RBM39, FBP1, LGALS9, RIN3, TOP3B, FBXL19, OGT, UFL1, DDRGK1, DHFRL1, TRIM37, SLC26A4-AS1, FZR1, WDR5, NUDCD2, CEBPZ, ZBTB24, SREK1, NIP7, DDX21, SNAPC1, VANGL2, NOC3L, NOC2L, BOP1, KNOP1, DDX24, WDR89, ZCCHC17, SRRM2, URB1, PRKRA, UBTF, DDX31, CENPB, RSBN1L, DDX27, NMNAT1, ZC3H10, GTPBP4, RRP1B, RPL32, DDX51, YBX1, ZNF48, GNL2, EPB41L5, SIN3B, DHX30, BBX, CWC22, BRIX1, TNRC18, SNAPC4, NAF1, RBM28, FTSJ3, VANGL1, NVL, SPRTN, BTF3, FBXW7, MRFAP1, CCNF, N,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL22	ACC	chr1	6257785	6257785	T	-	Frame_Shift_Del	p.K15fs	82
RPL22	ACC	chr1	6257785	6257785	T	-	Frame_Shift_Del	p.K16fs	13
RPL22	CESC	chr1	6257785	6257785	T	-	Frame_Shift_Del		12
RPL22	BLCA	chr1	6257784	6257785	-	T	Frame_Shift_Ins	p.K15fs	8
RPL22	LUAD	chr1	6253091	6253091	G	C	Missense_Mutation	p.I47M	7
RPL22	LIHC	chr1	6246852	6246852	T	-	Frame_Shift_Del	p.K89fs	6
RPL22	BRCA	chr1	6246831	6246831	T	G	Silent	p.L96	3
RPL22	UCEC	chr1	6246817	6246817	C	T	Missense_Mutation	p.R101H	2
RPL22	KIRP	chr1	6246873	6246873	A	T	Nonsense_Mutation	p.Y82X	2
RPL22	SKCM	chr1	6253107	6253107	A	G	Missense_Mutation	p.F42S	2
RPL22	UCEC	chr1	6246853	6246853	T	G	Missense_Mutation	p.K89T	2
RPL22	KIRP	chr1	6246873	6246873	A	T	Nonsense_Mutation	p.Y82*	2
RPL22	UCEC	chr1	6246855	6246855	T	G	Missense_Mutation	p.K88N	2
RPL22	UCEC	chr1	6257713	6257713	A	T	Missense_Mutation	p.F39Y	2
RPL22	UCEC	chr1	6257784	6257785	-	T	Frame_Shift_Ins	p.K16fs	2
RPL22	ACC	chr1	6246838	6246840	TTC	-	In_Frame_Del	p.94_94del	2
RPL22	STAD	chr1	6246818	6246818	G	A	Missense_Mutation	p.R101C	2
RPL22	HNSC	chr1	6253065	6253065	A	G	Missense_Mutation	p.L56P	2
RPL22	STAD	chr1	6257785	6257786	TT	-	Frame_Shift_Del	p.15_15del	2
RPL22	KIRC	chr1	6246862	6246862	A	G	Missense_Mutation	p.L86P	2
RPL22	BLCA	chr1	6257784	6257785	-	-	Frame_Shift_Ins		2
RPL22	STAD	chr1	6253081	6253081	C	T	Missense_Mutation	p.G51R	2
RPL22	KIRC	chr1	6246851	6246852	-	T	Frame_Shift_Ins	p.Y90fs	2
RPL22	KIRC	chr1	6246851	6246852	-	T	Frame_Shift_Ins	p.F90fs	2
RPL22	SKCM	chr1	6253066	6253066	G	A	Missense_Mutation	p.L56F	2
RPL22	SKCM	chr1	6253009	6253009	C	A	Nonsense_Mutation	p.E75X	1
RPL22	COAD	chr1	6246851	6246851	A	G	Missense_Mutation	p.Y90H	1
RPL22	KIRP	chr1	6246873	6246873	A	T	Nonsense_Mutation		1
RPL22	SKCM	chr1	6253009	6253009	C	A	Nonsense_Mutation	p.E75*	1
RPL22	ESCA	chr1	6253011	6253011	G	T	Missense_Mutation		1
RPL22	LGG	chr1	6257818	6257818	T	A	Splice_Site	.	1
RPL22	SKCM	chr1	6246833	6246833	G	A	Silent	p.L96L	1
RPL22	HNSC	chr1	6253065	6253065	A	G	Missense_Mutation		1
RPL22	LIHC	chr1	6253019	6253019	G	T	Silent		1
RPL22	SKCM	chr1	6252996	6252996	G	A	Missense_Mutation	p.S79F	1
RPL22	HNSC	chr1	6253099	6253099	C	T	Missense_Mutation		1
RPL22	LIHC	chr1	6257754	6257754	G	T	Nonsense_Mutation	p.C25X	1
RPL22	STAD	chr1	6246818	6246818	G	A	Missense_Mutation		1
RPL22	HNSC	chr1	6253099	6253099	C	T	Missense_Mutation	p.E45K	1
RPL22	LIHC	chr1	6257754	6257754	G	T	Nonsense_Mutation	p.C25*	1
RPL22	ACC	chr1	6246838	6246840	TTC	-	In_Frame_Del	p.KN93del	1
RPL22	OV	chr1	6169417	6169417	G	A	Missense_Mutation	p.R97C	1
RPL22	STAD	chr1	6257728	6257728	A	C	Missense_Mutation	p.M34R	1

Copy number variation (CNV) of RPL22
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPL22
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
100420	BRCA	TCGA-AN-A0FT	ACOT7	chr1	6387358	-	RPL22	chr1	6253114	-
100420	LGG	TCGA-DU-A5TT	ACOT7	chr1	6387358	-	RPL22	chr1	6246876	-
100420	N/A	N66339	AFAP1L2	chr10	116109312	-	RPL22	chr1	6245094	+
100420	STAD	TCGA-HU-A4HB-01A	AHI1	chr6	135811761	-	RPL22	chr1	6257816	-
100420	N/A	FN138778	DLG2	chr11	85189546	+	RPL22	chr1	6246260	-
100420	N/A	BU858788	MAP3K2	chr2	128062363	-	RPL22	chr1	6246465	-
100420	N/A	AA420829	MECOM	chr3	169201808	+	RPL22	chr1	6246675	+
100420	N/A	EC559899	RADIL	chr7	4905334	-	RPL22	chr1	6257817	-
100420	SKCM	TCGA-D3-A3MV-06A	RCC1	chr1	28834672	+	RPL22	chr1	6257816	-
98723	STAD	TCGA-BR-A452	RPL22	chr1	6252989	-	ACOT7	chr1	6324755	-
98723	STAD	TCGA-BR-A4QI-01A	RPL22	chr1	6252990	-	ACOT7	chr1	6324755	-
76164	N/A	BM013571	RPL22	chr1	6246675	-	CPA2	chr7	129923133	-
101264	N/A	CR738829	RPL22	chr1	6245384	-	DLC1	chr8	12941285	-
89764	PRAD	TCGA-KK-A5A1-01A	RPL22	chr1	6257712	-	DNAJC11	chr1	6714099	-
100803	N/A	BF338721	RPL22	chr1	6246675	-	ERG	chr21	39818145	+
101735	ESCA	TCGA-2H-A9GK	RPL22	chr1	6252989	-	MECOM	chr3	169099312	-
102124	N/A	BG574777	RPL22	chr1	6246675	-	MKL1	chr22	41006067	-
84752	N/A	BF846664	RPL22	chr1	6246042	+	PCSK6	chr15	101871293	-
98891	COAD	TCGA-A6-2679-01A	RPL22	chr1	6257713	-	PDE6A	chr5	149246804	-
95065	HNSC	TCGA-CV-7434	RPL22	chr1	6252989	-	PHF16	chrX	46844284	+
84283	N/A	BF185866	RPL22	chr1	6246852	-	PPARGC1A	chr4	23976453	-
76164	N/A	BG576945	RPL22	chr1	6246677	-	PPP3CA	chr4	102197050	-
94215	SARC	TCGA-DX-AB2X-01A	RPL22	chr1	6257712	-	PRDM16	chr1	3342145	+
101261	OV	TCGA-23-1118-01A	RPL22	chr1	6246763	-	PTMA	chr2	232576638	+
97174	LUSC	TCGA-68-8251-01A	RPL22	chr1	6257712	-	RER1	chr1	2327223	+
101411	N/A	CD579559	RPL22	chr1	6246475	-	RFC3	chr13	34437089	-
76164	LIHC	TCGA-EP-A2KA	RPL22	chr1	6252989	-	RNF207	chr1	6278348	+
76164	LIHC	TCGA-EP-A2KA-01A	RPL22	chr1	6252990	-	RNF207	chr1	6278349	+
76164	N/A	EC516024	RPL22	chr1	6257713	-	RPL22P19	chr12	125420352	-
92890	ESCA	TCGA-VR-AA4D	RPL22	chr1	6252989	-	SLMAP	chr3	57908615	+
96490	N/A	AA879157	RPL22	chr1	6246675	-	STK10	chr5	171528473	+
100932	N/A	BD309585	RPL22	chr1	6245165	-	SYNE1	chr6	152636356	-
97100	N/A	BD264640	RPL22	chr1	6246397	+	TP53BP1	chr15	43785339	-
76164	LUSC	TCGA-60-2703	RPL22	chr1	6252989	-	UBE2D3	chr4	103747793	-
100420	STAD	TCGA-HU-A4GH-01A	TBL2	chr7	72992750	-	RPL22	chr1	6246876	-
100420	STAD	TCGA-D7-6527	TXNL4B	chr16	72122885	-	RPL22	chr1	6257816	-
100421	KICH	TCGA-KO-8404	ZBTB38	chr3	141087646	+	RPL22	chr1	6257816	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
THYM	RPL22	0.0202969846704409	0.57
SARC	RPL22	0.0254745401955233	0.69

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KICH	RPL22	0.0361979454462499	1
GBM	RPL22	0.0254865540856316	0.79
LGG	RPL22	1.83116450201151e-07	6e-06
BRCA	RPL22	0.0016620319551077	0.053

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source