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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL23A (NCBI Gene ID:6147)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL23A
	Gene ID: 6147
	Gene Symbol	RPL23A
	Gene ID	6147
	Gene Name	ribosomal protein L23a
	Synonyms	L23A\|MDA20
	Cytomap	17q11.2
	Type of Gene	protein-coding
	Description	60S ribosomal protein L23alarge ribosomal subunit protein uL23melanoma differentiation-associated gene 20
	Modification date	20200313
	UniProtAcc	P62750

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPL23A	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPL23A[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL23A	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000422514	27049740	27049917	In-frame
ENST00000422514	27050588	27050658	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000422514	27049740	27049917	1579	823	999	156	70	128

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P62750	70	128	2	156	Chain	ID=PRO_0000129467;Note=60S ribosomal protein L23a
P62750	70	128	70	70	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P62751
P62750	70	128	99	99	Natural variant	ID=VAR_069221;Note=Rare variant found in Diamond-Blackfan anemia patients%3B unknown pathological significance. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:22431104;Dbxref=dbSNP:rs151327030,PMID:22431104
P62750	70	128	78	78	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
P62750	70	128	110	110	Sequence conflict	Note=K->S;Ontology_term=ECO:0000305;evidence=ECO:0000305

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
BRCA	RPL23A	-1.00708839787202	0.0188078315893149
KIRP	RPL23A	-1.52936455976751	1.2875534594059e-06
LUAD	RPL23A	-2.22526108535187	7.13242533835451e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL23A (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	RPL23A	SNRPD2	0.82596456	2.87E-12
CHOL	Epifactor	RPL23A	FBL	0.839740246	5.63E-13
DLBC	Cell metabolism gene	RPL23A	TOMM7	0.800945522	8.18E-12
DLBC	Cell metabolism gene	RPL23A	PGLS	0.803627233	6.17E-12
DLBC	Cell metabolism gene	RPL23A	POLR2I	0.811256956	2.71E-12
DLBC	Cell metabolism gene	RPL23A	PTDSS2	0.811765146	2.56E-12
DLBC	Cell metabolism gene	RPL23A	PSMB3	0.819797988	1.03E-12
DLBC	Cell metabolism gene	RPL23A	GFER	0.825248885	5.41E-13
DLBC	Cell metabolism gene	RPL23A	POLR2J	0.82694907	4.41E-13
DLBC	Cell metabolism gene	RPL23A	GEMIN7	0.827305815	4.22E-13
DLBC	Cell metabolism gene	RPL23A	TIMM13	0.835764026	1.47E-13
DLBC	Cell metabolism gene	RPL23A	TIMM9	0.836898154	1.27E-13
DLBC	Cell metabolism gene	RPL23A	TOMM22	0.840726727	7.65E-14
DLBC	Cell metabolism gene	RPL23A	POLR2F	0.851710659	1.68E-14
DLBC	Cell metabolism gene	RPL23A	PFDN5	0.859847384	5.02E-15
DLBC	Cell metabolism gene	RPL23A	FAU	0.891587749	1.95E-17
DLBC	Cell metabolism gene	RPL23A	NME2	0.89302998	1.45E-17
DLBC	Cell metabolism gene	RPL23A	SNRPD2	0.906436114	7.75E-19
DLBC	CGC	RPL23A	NACA	0.874314062	4.82E-16
DLBC	Epifactor	RPL23A	FBL	0.882101625	1.21E-16
DLBC	IUPHAR	RPL23A	MFSD2B	0.810094881	3.08E-12
DLBC	TF	RPL23A	THAP4	0.81909908	1.12E-12
DLBC	TF	RPL23A	ZNF444	0.822235021	7.75E-13
DLBC	TF	RPL23A	ZNF581	0.841562547	6.85E-14
DLBC	TF	RPL23A	NME2	0.89302998	1.45E-17
DLBC	TSG	RPL23A	GLTSCR2	0.822251649	7.74E-13
DLBC	TSG	RPL23A	PARK7	0.822387684	7.61E-13
DLBC	TSG	RPL23A	GADD45GIP1	0.849128879	2.42E-14
DLBC	TSG	RPL23A	GNB2L1	0.923163081	1.00E-20
GBM	TF	RPL23A	ZNF90	0.808033322	6.52E-41
KIRP	Cell metabolism gene	RPL23A	SNRPD2	0.842533871	2.95E-88
LGG	Cell metabolism gene	RPL23A	FAU	0.833096795	6.78E-138
LIHC	Epifactor	RPL23A	FBL	0.819430712	8.23E-104
PAAD	Cell metabolism gene	RPL23A	FAU	0.804801903	7.25E-43
PRAD	Cell metabolism gene	RPL23A	TOMM7	0.803581998	1.38E-125
PRAD	Cell metabolism gene	RPL23A	FAU	0.808906101	1.65E-128
PRAD	Cell metabolism gene	RPL23A	NME2	0.815680366	2.31E-132
PRAD	Cell metabolism gene	RPL23A	SNRPD2	0.824148681	2.07E-137
PRAD	Cell metabolism gene	RPL23A	TIMM9	0.827944768	9.22E-140
PRAD	CGC	RPL23A	NACA	0.82851108	4.07E-140
PRAD	Epifactor	RPL23A	FBL	0.853530776	2.80E-157
PRAD	TF	RPL23A	NME2	0.815680366	2.31E-132
PRAD	TSG	RPL23A	GAS5	0.804577396	3.98E-126
PRAD	TSG	RPL23A	GNB2L1	0.858300116	6.48E-161
THYM	Cell metabolism gene	RPL23A	NUDT2	0.805800135	4.45E-29
THYM	Cell metabolism gene	RPL23A	POLD4	0.806721983	3.45E-29
THYM	Cell metabolism gene	RPL23A	APRT	0.807273226	2.95E-29
THYM	Cell metabolism gene	RPL23A	TIMM50	0.808496758	2.10E-29
THYM	Cell metabolism gene	RPL23A	GFER	0.813994298	4.35E-30
THYM	Cell metabolism gene	RPL23A	PSMB1	0.814387931	3.88E-30
THYM	Cell metabolism gene	RPL23A	EXOSC4	0.815246919	3.02E-30
THYM	Cell metabolism gene	RPL23A	ACOT8	0.816586528	2.04E-30
THYM	Cell metabolism gene	RPL23A	OAZ1	0.818196126	1.26E-30
THYM	Cell metabolism gene	RPL23A	MVD	0.81869538	1.09E-30
THYM	Cell metabolism gene	RPL23A	IMPDH2	0.822029353	3.97E-31
THYM	Cell metabolism gene	RPL23A	PSMD13	0.822423534	3.52E-31
THYM	Cell metabolism gene	RPL23A	NT5C	0.822616218	3.32E-31
THYM	Cell metabolism gene	RPL23A	PSMB3	0.825957381	1.18E-31
THYM	Cell metabolism gene	RPL23A	PSMB7	0.831310985	2.14E-32
THYM	Cell metabolism gene	RPL23A	DPM2	0.832699242	1.36E-32
THYM	Cell metabolism gene	RPL23A	PSMC3	0.833824859	9.42E-33
THYM	Cell metabolism gene	RPL23A	TALDO1	0.843845696	3.09E-34
THYM	Cell metabolism gene	RPL23A	SLC27A5	0.84661078	1.15E-34
THYM	Cell metabolism gene	RPL23A	PSMC5	0.850926178	2.39E-35
THYM	Cell metabolism gene	RPL23A	TIMM13	0.852159404	1.51E-35
THYM	Cell metabolism gene	RPL23A	TIMM8B	0.858477402	1.33E-36
THYM	Cell metabolism gene	RPL23A	SNRPD2	0.860028363	7.23E-37
THYM	Cell metabolism gene	RPL23A	SSR2	0.861607184	3.85E-37
THYM	Cell metabolism gene	RPL23A	PFDN5	0.87531773	1.12E-39
THYM	Cell metabolism gene	RPL23A	FAU	0.882960312	3.20E-41
THYM	CGC	RPL23A	ASPSCR1	0.806309477	3.86E-29
THYM	CGC	RPL23A	SDHAF2	0.834218755	8.28E-33
THYM	Epifactor	RPL23A	TAF10	0.80850385	2.09E-29
THYM	Epifactor	RPL23A	MBD3	0.810035286	1.36E-29
THYM	Epifactor	RPL23A	SIRT6	0.815027023	3.22E-30
THYM	Epifactor	RPL23A	EXOSC4	0.815246919	3.02E-30
THYM	Epifactor	RPL23A	PRPF31	0.820164061	7.00E-31
THYM	Epifactor	RPL23A	NOC2L	0.82266073	3.27E-31
THYM	Epifactor	RPL23A	BRMS1	0.840543802	9.79E-34
THYM	Epifactor	RPL23A	FBL	0.892165497	3.11E-43
THYM	IUPHAR	RPL23A	PSMB1	0.814387931	3.88E-30
THYM	IUPHAR	RPL23A	SIRT6	0.815027023	3.22E-30
THYM	IUPHAR	RPL23A	MVD	0.81869538	1.09E-30
THYM	IUPHAR	RPL23A	IMPDH2	0.822029353	3.97E-31
THYM	IUPHAR	RPL23A	NT5C	0.822616218	3.32E-31
THYM	IUPHAR	RPL23A	SLC27A5	0.84661078	1.15E-34
THYM	TF	RPL23A	THAP3	0.804256909	6.81E-29
THYM	TF	RPL23A	ZNF787	0.806148992	4.04E-29
THYM	TF	RPL23A	MBD3	0.810035286	1.36E-29
THYM	TF	RPL23A	REXO4	0.841548008	6.91E-34
THYM	TF	RPL23A	ZNF581	0.847086155	9.73E-35
THYM	TSG	RPL23A	GLTSCR2	0.804981149	5.58E-29
THYM	TSG	RPL23A	NPRL2	0.805405513	4.96E-29
THYM	TSG	RPL23A	SIRT6	0.815027023	3.22E-30
THYM	TSG	RPL23A	GADD45GIP1	0.817541294	1.54E-30
THYM	TSG	RPL23A	GNB2L1	0.820584997	6.16E-31
THYM	TSG	RPL23A	PHB	0.822449048	3.49E-31
THYM	TSG	RPL23A	BRMS1	0.840543802	9.79E-34
THYM	TSG	RPL23A	TSSC4	0.870285301	1.03E-38
UCS	Cell metabolism gene	RPL23A	NUDT2	0.805800135	4.45E-29
UCS	Cell metabolism gene	RPL23A	POLD4	0.806721983	3.45E-29
UCS	Cell metabolism gene	RPL23A	APRT	0.807273226	2.95E-29
UCS	Cell metabolism gene	RPL23A	TIMM50	0.808496758	2.10E-29
UCS	Cell metabolism gene	RPL23A	GFER	0.813994298	4.35E-30
UCS	Cell metabolism gene	RPL23A	PSMB1	0.814387931	3.88E-30
UCS	Cell metabolism gene	RPL23A	EXOSC4	0.815246919	3.02E-30
UCS	Cell metabolism gene	RPL23A	ACOT8	0.816586528	2.04E-30
UCS	Cell metabolism gene	RPL23A	OAZ1	0.818196126	1.26E-30
UCS	Cell metabolism gene	RPL23A	MVD	0.81869538	1.09E-30
UCS	Cell metabolism gene	RPL23A	IMPDH2	0.822029353	3.97E-31
UCS	Cell metabolism gene	RPL23A	PSMD13	0.822423534	3.52E-31
UCS	Cell metabolism gene	RPL23A	NT5C	0.822616218	3.32E-31
UCS	Cell metabolism gene	RPL23A	PSMB3	0.825957381	1.18E-31
UCS	Cell metabolism gene	RPL23A	PSMB7	0.831310985	2.14E-32
UCS	Cell metabolism gene	RPL23A	DPM2	0.832699242	1.36E-32
UCS	Cell metabolism gene	RPL23A	PSMC3	0.833824859	9.42E-33
UCS	Cell metabolism gene	RPL23A	TALDO1	0.843845696	3.09E-34
UCS	Cell metabolism gene	RPL23A	SLC27A5	0.84661078	1.15E-34
UCS	Cell metabolism gene	RPL23A	PSMC5	0.850926178	2.39E-35
UCS	Cell metabolism gene	RPL23A	TIMM13	0.852159404	1.51E-35
UCS	Cell metabolism gene	RPL23A	TIMM8B	0.858477402	1.33E-36
UCS	Cell metabolism gene	RPL23A	SNRPD2	0.860028363	7.23E-37
UCS	Cell metabolism gene	RPL23A	SSR2	0.861607184	3.85E-37
UCS	Cell metabolism gene	RPL23A	PFDN5	0.87531773	1.12E-39
UCS	Cell metabolism gene	RPL23A	FAU	0.882960312	3.20E-41
UCS	CGC	RPL23A	ASPSCR1	0.806309477	3.86E-29
UCS	CGC	RPL23A	SDHAF2	0.834218755	8.28E-33
UCS	Epifactor	RPL23A	TAF10	0.80850385	2.09E-29
UCS	Epifactor	RPL23A	MBD3	0.810035286	1.36E-29
UCS	Epifactor	RPL23A	SIRT6	0.815027023	3.22E-30
UCS	Epifactor	RPL23A	EXOSC4	0.815246919	3.02E-30
UCS	Epifactor	RPL23A	PRPF31	0.820164061	7.00E-31
UCS	Epifactor	RPL23A	NOC2L	0.82266073	3.27E-31
UCS	Epifactor	RPL23A	BRMS1	0.840543802	9.79E-34
UCS	Epifactor	RPL23A	FBL	0.892165497	3.11E-43
UCS	IUPHAR	RPL23A	PSMB1	0.814387931	3.88E-30
UCS	IUPHAR	RPL23A	SIRT6	0.815027023	3.22E-30
UCS	IUPHAR	RPL23A	MVD	0.81869538	1.09E-30
UCS	IUPHAR	RPL23A	IMPDH2	0.822029353	3.97E-31
UCS	IUPHAR	RPL23A	NT5C	0.822616218	3.32E-31
UCS	IUPHAR	RPL23A	SLC27A5	0.84661078	1.15E-34
UCS	TF	RPL23A	THAP3	0.804256909	6.81E-29
UCS	TF	RPL23A	ZNF787	0.806148992	4.04E-29
UCS	TF	RPL23A	MBD3	0.810035286	1.36E-29
UCS	TF	RPL23A	REXO4	0.841548008	6.91E-34
UCS	TF	RPL23A	ZNF581	0.847086155	9.73E-35
UCS	TSG	RPL23A	GLTSCR2	0.804981149	5.58E-29
UCS	TSG	RPL23A	NPRL2	0.805405513	4.96E-29
UCS	TSG	RPL23A	SIRT6	0.815027023	3.22E-30
UCS	TSG	RPL23A	GADD45GIP1	0.817541294	1.54E-30
UCS	TSG	RPL23A	GNB2L1	0.820584997	6.16E-31
UCS	TSG	RPL23A	PHB	0.822449048	3.49E-31
UCS	TSG	RPL23A	BRMS1	0.840543802	9.79E-34
UCS	TSG	RPL23A	TSSC4	0.870285301	1.03E-38
UVM	Cell metabolism gene	RPL23A	TOMM22	0.810860631	7.85E-20
UVM	Cell metabolism gene	RPL23A	IMPDH2	0.828437918	2.50E-21
UVM	Cell metabolism gene	RPL23A	FAU	0.832606075	1.04E-21
UVM	Epifactor	RPL23A	FBL	0.807900314	1.35E-19
UVM	IUPHAR	RPL23A	IMPDH2	0.828437918	2.50E-21
UVM	TF	RPL23A	ZNF581	0.819459762	1.52E-20
UVM	TSG	RPL23A	GNB2L1	0.864076868	5.79E-25

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPL23A	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPL23A	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPL23A	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPL23A	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPL23A	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPL23A	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPL23A	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPL23A	RPL19	1.36901182894089	0.00250792503356934
KICH	RPL23A	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPL23A	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPL23A	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPL23A	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPL23A	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPL23A	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPL23A	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPL23A	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPL23A	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPL23A	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPL23A	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPL23A	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPL23A	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPL23A	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPL23A	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPL23A	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPL23A	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPL23A	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPL23A	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPL23A	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL23A

LYAR, PSTPIP1, MAGEB2, PACSIN3, DDX56, CNBP, PINX1, RTCA, IPO5, IPO7, IPO8, TNPO1, kpnb2, NOP56, MTOR, RICTOR, RAD21, SIRT7, TCF3, CUL3, CUL4A, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, DCUN1D1, CAND1, NEDD8, MRTO4, RPL11, RPL14, RPL15, RPL18A, RPL21, RPL23, RPL24, RPL27A, RPL31, RPL3, RPL5, RPL7, RPL8, RPS16, RPS19, RPS23, RPS3, RPS4X, RPL18, RPL19, RPS8, RPL13, RPL10A, RPS11, RPS26, RPL9, RPL6, RPS15A, RPL37A, RPS6, RPL7A, RPS2, RPS5, RPS20, RPS25, RPL12, RPS7, RPS3A, RPL4, RPL30, RPSA, RPS14, RPS24, RPL22, RPS13, RPLP0, RPS28, RPL35, RPL36, RPS9, RPL10, RPL38, RPL29, RPL32, RPL17, RPS21, RPS27A, EEF1A1, FAU, MYBBP1A, ILF3, SLC25A5, ILF2, HNRNPU, HNRNPM, TUFM, NOLC1, NHP2L1, RPL10L, RPLP0P6, RPS27L, VASN, NOP2, RPS10P5, HSP90AA1, ESR1, FN1, UBL4A, ITGA4, SF3B1, PAN2, CD81, IGSF8, ICAM1, CTPS2, TARDBP, PARK2, AIMP1, EIF3CL, IARS, QARS, NELFB, DARS, DIMT1, EEF1E1, EIF3D, EPRS, IGF2BP3, MAP2, NMT1, PA2G4, PPIA, YBX1, RPS27, SND1, SYNCRIP, CEP250, CEP76, TP53, TUBGCP3, CUL7, OBSL1, EED, RNF2, NPM1, PRR11, RPS6KB2, MRPL15, MRPL16, MRPS10, MRPS7, RPL13A, GFM1, RPL27, RPL28, RPL34, RPL3L, RPLP2, RPS17, LOC101929876, SLC1A2, RPL35A, RPLP1, RPS10, RPS12, RPS15, RPS18, SFN, BLM, XPO1, KIF11, Eif3a, Eif3e, Eif3i, Rpl35, Srp72, Rrbp1, MCM2, Ksr1, GNL2, MDM2, RC3H1, C1orf131, CDH1, RRS1, H2AFX, KIAA0020, NCL, CYLD, INO80B, TRIM25, BRCA1, MTF1, TRIM14, RMND5A, TMPO, ACO2, WDR77, TGFB1, BMP4, CTNNB1, KRAS, TRIP4, PYHIN1, PRPF8, EFTUD2, AAR2, PIH1D1, SHARPIN, CHD3, RNF4, CHD4, LARP7, RNF31, RIOK1, HEXIM1, MEPCE, PPT1, SNAI1, AGR2, RECQL4, GPC1, REST, MYC, CDK9, Prkaa1, Prkab1, GRWD1, EIF4B, RC3H2, ACTC1, PHB, RBX1, NR2C2, PPP1CC, EIF5A, VRK1, VRK3, HIST1H4A, SNRNP70, Dppa3, PTPN6, ITFG1, ARAF, HMGB1, BIRC3, NFX1, WWP2, CMTR1, ARIH2, PINK1, YAP1, TFCP2, FANCD2, PTEN, HCVgp1, ZC3H18, GRB7, EMC4, HMGN2, DDX10, HIST1H2BH, AHNAK, LOC102724334, SNIP1, M, nsp4, nsp6, NAP1L1, NEK4, DUX4, CIT, ANLN, AURKB, CHMP4B, ECT2, KIF14, KIF20A, KIF23, PRC1, C1QBP, GRSF1, RPN1, LRRC59, INS, NDN, BRD4, N, Apc2, RBM39, FBP1, MKRN1, USP15, NONO, TSPYL5, TOP1, NUFIP2, METTL17, SFPQ, SUV420H2, DDX42, NDC80, PPIL4, LIN28A, SP100, POP1, ATXN2L, CPSF7, NSRP1, PSPC1, SART1, PPP1R10, CBX4, FAM76B, NUDT21, NPM3, DCAF13, JADE1, SET, YY1, RRP1B, NOP16, SETD8, RPL7L1, NUSAP1, NF2, H1FX, BAG5, ATG5, ISG15, UFL1, DDRGK1, SSR1, TRIM37, ATG7, ATG3, UBQLN1, FZR1, WDR5, NUDCD2, NVL, TFB1M, CDK13, NSD1, MRPL28, VPRBP, DHX57, FNTB, ZNF317, DDX55, ZNF92, DDX31, ZNF771, BRIX1, ZNF48, RSBN1, UBE2O, KRR1, CCDC86, ZNF189, WHSC1, C3orf17, HERC5, DKC1, STAU2, ZNF107, MKRN4P, PABPC4L, SF3B2, ASH1L, PURA, PURB, C8orf33, RPF1, NMNAT1, PRKRA, TOE1, RPL23AP32, GZF1, ZNF888, RPL36AL, RPS26P11, ZNF358, ZNF346, HIST1H1B, STAU1, GLYR1, MPHOSPH10, YTHDC1, DDX27, ZNF616, ZNF70, CTCF, RBM19, PDCD11, DAXX, PRDM10, ELAVL2, ZSCAN25, PRDM15, ZBTB48, SRSF5, TAF1D, NOP14, KNOP1, TRMT1L, TTF1, CMSS1, RRP12, ZNF711, PARN, NOC4L, GTPBP4, ZNF770, RSBN1L, ZCRB1, RPL26L1, KRI1, MRPS26, ZC3H8, URB2, ZNF800, NAT10, RBM28, ZNF668, DDX21, BMS1, ZC3HAV1, SURF6, YBX3, RSL24D1, MRPS35, GGACT, RNMTL1, HIST1H2AM, SREK1, MRPL13, CCDC137, MRPL32, DHX36, NSA2, FAM111A, DGCR8, MRPS24, GLTSCR2, UTP3, MRPL55, MRPL48, SRPK2, MRPL52, MRPL35, MRPL57, NOC3L, ZNF768, PAK1IP1, MRPS18C, MRPS30, MRPS18A, DHX30, MRPL23, NOP9, CDC5L, NEIL1, MRPS25, DDX24, FNTA, MRPS33, ABT1, HIST2H2AB, HIST1H1E, DDX18, MRPL17, RBM34, NIFK, NKRF, MRPS14, ZFP91, MRPL18, FTSJ3, YTHDC2, RPS4Y1, MRPL46, GADD45GIP1, MRPL9, NAP1L4, ZC3H3, MRPL2, PPAN-P2RY11, BTF3, FBXW7, TFIP11, CTTN, Htatsf1, Nono, NLRP7, RCHY1, CALCOCO2, SIRT6, ZEB1,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL23A	UCEC	chr17	27047820	27047820	C	T	Missense_Mutation	p.R41C	2
RPL23A	STAD	chr17	27049750	27049750	C	A	Missense_Mutation		2
RPL23A	UCEC	chr17	27049755	27049755	C	A	Missense_Mutation	p.A75D	2
RPL23A	STAD	chr17	27049750	27049750	C	A	Missense_Mutation	p.H73Q	2
RPL23A	STAD	chr17	27047880	27047880	C	G	Missense_Mutation	p.P61A	2
RPL23A	LIHC	chr17	27049757	27049757	A	G	Missense_Mutation	p.I76V	2
RPL23A	BLCA	chr17	27047838	27047838	C	T	Missense_Mutation	p.R47W	2
RPL23A	THYM	chr17	27049790	27049790	A	G	Missense_Mutation	p.M87V	2
RPL23A	LUAD	chr17	27050632	27050632	T	G	Missense_Mutation	p.Y144D	2
RPL23A	LUAD	chr17	27047846	27047846	G	A	Silent	p.P49P	2
RPL23A	UCEC	chr17	27047361	27047361	C	A	Missense_Mutation	p.P18T	2
RPL23A	COAD	chr17	27047808	27047810	AAG	-	In_Frame_Del	p.36_37del	2
RPL23A	UCEC	chr17	27047808	27047810	AAG	-	In_Frame_Del	p.K39in_frame_del	2
RPL23A	UCEC	chr17	27047818	27047818	T	C	Missense_Mutation	p.I40T	2
RPL23A	BLCA	chr17	27047883	27047883	C	T	Missense_Mutation		1
RPL23A	ESCA	chr17	27046991	27046991	G	T	Missense_Mutation		1
RPL23A	BLCA	chr17	27047593	27047593	C	G	Missense_Mutation		1
RPL23A	KIRP	chr17	27047900	27047900	G	T	Missense_Mutation		1
RPL23A	BLCA	chr17	27049770	27049770	C	T	Missense_Mutation		1
RPL23A	LIHC	chr17	27049757	27049757	A	G	Missense_Mutation		1
RPL23A	BLCA	chr17	27047883	27047883	C	T	Missense_Mutation	p.R62W	1
RPL23A	STAD	chr17	27047808	27047810	AAG	-	In_Frame_Del	p.K39del	1
RPL23A	LIHC	chr17	27047804	27047805	-	A	Frame_Shift_Ins	p.QK35fs	1
RPL23A	THYM	chr17	27049790	27049790	A	G	Translation_Start_Site		1
RPL23A	BLCA	chr17	27047786	27047786	G	C	Missense_Mutation	p.L29F	1
RPL23A	LIHC	chr17	27050640	27050640	T	-	Frame_Shift_Del	p.A146fs	1
RPL23A	BLCA	chr17	27049770	27049770	C	T	Missense_Mutation	p.P80L	1
RPL23A	UCEC	chr17	27047820	27047820	C	T	Missense_Mutation	p.R79C	1
RPL23A	CESC	chr17	27047756	27047756	G	A	Silent		1
RPL23A	LUAD	chr17	27050643	27050643	G	T	Missense_Mutation	p.L147F	1
RPL23A	COAD	chr17	27047827	27047827	C	T	Missense_Mutation	p.S43L	1
RPL23A	LUSC	chr17	27047813	27047813	G	A	Silent	p.K76K	1
RPL23A	COAD	chr17	27050613	27050613	T	C	Silent	p.Y137Y	1
RPL23A	OV	chr17	27050601	27050601	G	C	Missense_Mutation	p.E133D	1

Copy number variation (CNV) of RPL23A
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPL23A
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
103067	BRCA	TCGA-E2-A14V-01A	AATF	chr17	35348156	+	RPL23A	chr17	27047725	+
76209	COAD	TCGA-AA-A03F-01A	RPL23A	chr17	27049897	+	IGHA1	chr14	106174988	-
91424	N/A	BG623888	RPL23A	chr17	27050502	+	NAA15	chr4	140278552	+
99178	N/A	BI494509	RPL23A	chr17	27050954	+	PCDH11Y	chrY	5036639	-
76209	N/A	BF246117	RPL23A	chr17	27050658	+	TLCD1	chr17	27050885	+
102850	N/A	DB117326	RPL23A	chr17	27047633	+	UBC	chr12	125399196	-
103067	UCEC	TCGA-FI-A2D2	RTN4R	chr22	20255593	-	RPL23A	chr17	27047724	+
103067	STAD	TCGA-CD-8531-01A	SCARNA17	chr18	47340432	+	RPL23A	chr17	27047725	+
103067	LIHC	TCGA-XR-A8TG-01A	TAOK1	chr17	27718042	+	RPL23A	chr17	27047725	+
103068	N/A	BI494497	ZNF846	chr19	9894202	-	RPL23A	chr17	27050954	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	RPL23A	0.00403224900459076	0.11
MESO	RPL23A	0.027266925403191	0.74
SKCM	RPL23A	0.0355244712429918	0.92

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	RPL23A	0.0326419036809371	1
LUSC	RPL23A	0.00901351909203906	0.3

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0006142	Malignant neoplasm of breast	1	CTD_human
C0030567	Parkinson Disease	1	CTD_human
C0678222	Breast Carcinoma	1	CTD_human
C1257931	Mammary Neoplasms, Human	1	CTD_human
C4704874	Mammary Carcinoma, Human	1	CTD_human