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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MRPL23 (NCBI Gene ID:6150)

Gene Summary

Gene Summary

Gene Information	Gene Name: MRPL23
	Gene ID: 6150
	Gene Symbol	MRPL23
	Gene ID	6150
	Gene Name	mitochondrial ribosomal protein L23
	Synonyms	L23MRP\|RPL23\|RPL23L
	Cytomap	11p15.5
	Type of Gene	protein-coding
	Description	39S ribosomal protein L23, mitochondrialL23 mitochondrial-related proteinL23mtMRP-L23mitochondrial large ribosomal subunit protein uL23mribosomal protein related to L23 (mitochondrial)
	Modification date	20200320
	UniProtAcc	Q16540

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0032543	Mitochondrial translation
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MRPL23	(67.6 - 355.7]

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Translation Studies in PubMed

We searched PubMed using 'MRPL23[title] AND translation [title] AND human.'

Gene	Title	PMID
MRPL23	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000381519	1973356	1973439	Frame-shift
ENST00000397298	1973356	1973439	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KIRC	MRPL23	-3.69381690661734	2.86841504015679e-07

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
BLCA	MRPL23	3	2	0.0334398138391682	0.673663305972567	0.556096117021277	0.0919872946139544	-0.5748432510715
SKCM	MRPL23	3	2	0.0287463960994155	0.669024231678487	0.561950820344545	-0.607903812536969	-1.14087141144849

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MRPL23 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
BRCA	TSG	MRPL23	TSSC4	0.808717603	1.55E-282
CESC	Cell metabolism gene	MRPL23	PSMD13	0.800320659	5.95E-70
DLBC	Cell metabolism gene	MRPL23	PFDN4	0.800726692	8.36E-12
DLBC	Cell metabolism gene	MRPL23	GEMIN7	0.800739231	8.35E-12
DLBC	Cell metabolism gene	MRPL23	ECHS1	0.805967325	4.81E-12
DLBC	Cell metabolism gene	MRPL23	ALDOA	0.806256677	4.67E-12
DLBC	Cell metabolism gene	MRPL23	HSD17B10	0.808600158	3.63E-12
DLBC	Cell metabolism gene	MRPL23	ACOT8	0.808622414	3.62E-12
DLBC	Cell metabolism gene	MRPL23	MMAB	0.809346948	3.34E-12
DLBC	Cell metabolism gene	MRPL23	SNRPD3	0.810871141	2.83E-12
DLBC	Cell metabolism gene	MRPL23	VKORC1	0.811790942	2.56E-12
DLBC	Cell metabolism gene	MRPL23	ATP5G1	0.811850346	2.54E-12
DLBC	Cell metabolism gene	MRPL23	B3GAT3	0.812504135	2.36E-12
DLBC	Cell metabolism gene	MRPL23	MED27	0.814744812	1.84E-12
DLBC	Cell metabolism gene	MRPL23	DOHH	0.815346292	1.72E-12
DLBC	Cell metabolism gene	MRPL23	PFDN5	0.816009687	1.59E-12
DLBC	Cell metabolism gene	MRPL23	IDH3B	0.817975564	1.27E-12
DLBC	Cell metabolism gene	MRPL23	PGLS	0.819429022	1.08E-12
DLBC	Cell metabolism gene	MRPL23	UROD	0.821281281	8.67E-13
DLBC	Cell metabolism gene	MRPL23	SNRPB	0.821684014	8.27E-13
DLBC	Cell metabolism gene	MRPL23	TIMM8B	0.822457671	7.55E-13
DLBC	Cell metabolism gene	MRPL23	TIMM10	0.822880879	7.18E-13
DLBC	Cell metabolism gene	MRPL23	PSMB7	0.823363186	6.78E-13
DLBC	Cell metabolism gene	MRPL23	POLE4	0.827944425	3.91E-13
DLBC	Cell metabolism gene	MRPL23	ITPA	0.828020991	3.87E-13
DLBC	Cell metabolism gene	MRPL23	PHPT1	0.829904933	3.07E-13
DLBC	Cell metabolism gene	MRPL23	PSMA7	0.833013368	2.08E-13
DLBC	Cell metabolism gene	MRPL23	PSMB4	0.835544378	1.51E-13
DLBC	Cell metabolism gene	MRPL23	FAU	0.839793296	8.66E-14
DLBC	Cell metabolism gene	MRPL23	PSMC5	0.839924805	8.51E-14
DLBC	Cell metabolism gene	MRPL23	TPI1	0.843048285	5.61E-14
DLBC	Cell metabolism gene	MRPL23	POLR2I	0.84373243	5.11E-14
DLBC	Cell metabolism gene	MRPL23	PSMD4	0.845273972	4.14E-14
DLBC	Cell metabolism gene	MRPL23	LSM4	0.845897342	3.80E-14
DLBC	Cell metabolism gene	MRPL23	TOMM22	0.847596256	3.00E-14
DLBC	Cell metabolism gene	MRPL23	POLR2F	0.848514051	2.64E-14
DLBC	Cell metabolism gene	MRPL23	TIMM50	0.85079593	1.91E-14
DLBC	Cell metabolism gene	MRPL23	GFER	0.853082173	1.37E-14
DLBC	Cell metabolism gene	MRPL23	TIMM9	0.853209882	1.35E-14
DLBC	Cell metabolism gene	MRPL23	MTX1	0.857241279	7.44E-15
DLBC	Cell metabolism gene	MRPL23	PSMB6	0.863098865	3.03E-15
DLBC	Cell metabolism gene	MRPL23	SNRPD2	0.865733443	2.00E-15
DLBC	Cell metabolism gene	MRPL23	POLR2L	0.875878223	3.68E-16
DLBC	Cell metabolism gene	MRPL23	PTDSS2	0.877004374	3.02E-16
DLBC	Cell metabolism gene	MRPL23	NME2	0.881394439	1.37E-16
DLBC	Cell metabolism gene	MRPL23	TIMM13	0.895930314	7.98E-18
DLBC	Cell metabolism gene	MRPL23	EXOSC4	0.900956778	2.70E-18
DLBC	Cell metabolism gene	MRPL23	MIF	0.901624605	2.33E-18
DLBC	Cell metabolism gene	MRPL23	PSMB3	0.916082787	7.06E-20
DLBC	Cell metabolism gene	MRPL23	PSMD13	0.920506452	2.13E-20
DLBC	Cell metabolism gene	MRPL23	PSMC3	0.929633173	1.43E-21
DLBC	CGC	MRPL23	TFPT	0.817781702	1.30E-12
DLBC	CGC	MRPL23	COX6C	0.833059127	2.07E-13
DLBC	CGC	MRPL23	NTHL1	0.86326965	2.95E-15
DLBC	CGC	MRPL23	HRAS	0.890440355	2.45E-17
DLBC	Epifactor	MRPL23	DMAP1	0.810250313	3.03E-12
DLBC	Epifactor	MRPL23	TAF10	0.81126876	2.71E-12
DLBC	Epifactor	MRPL23	RRP8	0.812867565	2.27E-12
DLBC	Epifactor	MRPL23	TFPT	0.817781702	1.30E-12
DLBC	Epifactor	MRPL23	ZNHIT1	0.823148343	6.96E-13
DLBC	Epifactor	MRPL23	PPP4C	0.823995613	6.29E-13
DLBC	Epifactor	MRPL23	RBX1	0.826219196	4.82E-13
DLBC	Epifactor	MRPL23	FBL	0.826984386	4.39E-13
DLBC	Epifactor	MRPL23	PRPF31	0.830874717	2.72E-13
DLBC	Epifactor	MRPL23	RUVBL2	0.832038613	2.35E-13
DLBC	Epifactor	MRPL23	BRMS1	0.858804212	5.88E-15
DLBC	Epifactor	MRPL23	MBD3	0.866149578	1.87E-15
DLBC	Epifactor	MRPL23	EXOSC4	0.900956778	2.70E-18
DLBC	IUPHAR	MRPL23	MPDU1	0.801549187	7.68E-12
DLBC	IUPHAR	MRPL23	MFSD2B	0.804426917	5.67E-12
DLBC	IUPHAR	MRPL23	VKORC1	0.811790942	2.56E-12
DLBC	IUPHAR	MRPL23	BIRC5	0.823125791	6.98E-13
DLBC	IUPHAR	MRPL23	SLC25A26	0.823981967	6.30E-13
DLBC	IUPHAR	MRPL23	PSMB6	0.863098865	3.03E-15
DLBC	IUPHAR	MRPL23	HRAS	0.890440355	2.45E-17
DLBC	TF	MRPL23	THAP3	0.824009679	6.28E-13
DLBC	TF	MRPL23	THAP4	0.825966412	4.97E-13
DLBC	TF	MRPL23	ZNF408	0.827683236	4.03E-13
DLBC	TF	MRPL23	THAP7	0.848389267	2.69E-14
DLBC	TF	MRPL23	MBD3	0.866149578	1.87E-15
DLBC	TF	MRPL23	NME2	0.881394439	1.37E-16
DLBC	TF	MRPL23	PIN1	0.881944635	1.24E-16
DLBC	TSG	MRPL23	PHB	0.839628135	8.85E-14
DLBC	TSG	MRPL23	BRMS1	0.858804212	5.88E-15
DLBC	TSG	MRPL23	PIN1	0.881944635	1.24E-16
DLBC	TSG	MRPL23	TSSC4	0.900026208	3.32E-18
DLBC	TSG	MRPL23	GADD45GIP1	0.933500912	4.05E-22
GBM	Epifactor	MRPL23	TAF10	0.8012984	8.97E-40
HNSC	TSG	MRPL23	TSSC4	0.817386098	3.39E-137
KICH	CGC	MRPL23	HRAS	0.811580485	1.74E-22
KICH	Epifactor	MRPL23	BRMS1	0.869972666	4.53E-29
KICH	Epifactor	MRPL23	TAF10	0.895608809	4.60E-33
KICH	IUPHAR	MRPL23	HRAS	0.811580485	1.74E-22
KICH	TF	MRPL23	DRAP1	0.84060082	2.00E-25
KICH	TSG	MRPL23	TSSC4	0.85949121	1.12E-27
KICH	TSG	MRPL23	BRMS1	0.869972666	4.53E-29
KIRP	Cell metabolism gene	MRPL23	PSMC3	0.804377069	1.43E-74
KIRP	Cell metabolism gene	MRPL23	PGLS	0.822935176	8.15E-81
KIRP	Cell metabolism gene	MRPL23	FAU	0.827268954	2.23E-82
KIRP	Cell metabolism gene	MRPL23	POLR2I	0.871694954	1.88E-101
KIRP	Epifactor	MRPL23	TAF10	0.857609337	1.04E-94
KIRP	TSG	MRPL23	GADD45GIP1	0.890350999	1.01E-111
LAML	Cell metabolism gene	MRPL23	IDH3G	0.80440769	1.60E-40
LGG	Cell metabolism gene	MRPL23	PSMD13	0.812856658	4.92E-126
LGG	TSG	MRPL23	TSSC4	0.843422362	1.40E-144
MESO	IUPHAR	MRPL23	SIRT3	0.813183985	1.10E-21
MESO	TSG	MRPL23	SIRT3	0.813183985	1.10E-21
PAAD	Epifactor	MRPL23	TAF10	0.837936116	1.77E-49
PCPG	Epifactor	MRPL23	TAF10	0.814940209	1.06E-45
PRAD	Cell metabolism gene	MRPL23	TIMM8B	0.802847093	3.44E-125
PRAD	Cell metabolism gene	MRPL23	PFDN5	0.806373726	4.16E-127
PRAD	Cell metabolism gene	MRPL23	DPM2	0.80830082	3.58E-128
PRAD	Cell metabolism gene	MRPL23	OAZ1	0.810607209	1.84E-129
PRAD	Cell metabolism gene	MRPL23	B4GALT7	0.810629236	1.79E-129
PRAD	Cell metabolism gene	MRPL23	EXOSC4	0.812331061	1.94E-130
PRAD	Cell metabolism gene	MRPL23	PMVK	0.812728335	1.15E-130
PRAD	Cell metabolism gene	MRPL23	B3GAT3	0.816549864	7.21E-133
PRAD	Cell metabolism gene	MRPL23	GPX1	0.817215969	2.94E-133
PRAD	Cell metabolism gene	MRPL23	MPST	0.817257259	2.78E-133
PRAD	Cell metabolism gene	MRPL23	PSMC5	0.818069113	9.26E-134
PRAD	Cell metabolism gene	MRPL23	GUK1	0.818533859	4.93E-134
PRAD	Cell metabolism gene	MRPL23	PFDN6	0.819254565	1.84E-134
PRAD	Cell metabolism gene	MRPL23	ATP5G1	0.819635115	1.10E-134
PRAD	Cell metabolism gene	MRPL23	PTDSS2	0.82088786	1.96E-135
PRAD	Cell metabolism gene	MRPL23	PPCDC	0.821735996	6.05E-136
PRAD	Cell metabolism gene	MRPL23	PTGES2	0.822720398	1.54E-136
PRAD	Cell metabolism gene	MRPL23	TIMM17B	0.826942887	3.90E-139
PRAD	Cell metabolism gene	MRPL23	ITPA	0.827588054	1.54E-139
PRAD	Cell metabolism gene	MRPL23	HSD17B10	0.828561952	3.78E-140
PRAD	Cell metabolism gene	MRPL23	PSMD4	0.830537303	2.12E-141
PRAD	Cell metabolism gene	MRPL23	LSM4	0.831414436	5.81E-142
PRAD	Cell metabolism gene	MRPL23	TIMM50	0.83688013	1.56E-145
PRAD	Cell metabolism gene	MRPL23	GPX4	0.838233554	1.95E-146
PRAD	Cell metabolism gene	MRPL23	POLR2L	0.846166317	6.53E-152
PRAD	Cell metabolism gene	MRPL23	PHPT1	0.846187635	6.31E-152
PRAD	Cell metabolism gene	MRPL23	GFER	0.847262518	1.08E-152
PRAD	Cell metabolism gene	MRPL23	DPM3	0.848004908	3.17E-153
PRAD	Cell metabolism gene	MRPL23	IDH3G	0.852597756	1.39E-156
PRAD	Cell metabolism gene	MRPL23	SNRPD2	0.86065571	9.25E-163
PRAD	Cell metabolism gene	MRPL23	PSMB7	0.863391623	6.03E-165
PRAD	Cell metabolism gene	MRPL23	POLR2F	0.866761843	1.05E-167
PRAD	Cell metabolism gene	MRPL23	FAU	0.869630119	4.10E-170
PRAD	Cell metabolism gene	MRPL23	PSMB3	0.870191867	1.36E-170
PRAD	Cell metabolism gene	MRPL23	TIMM13	0.871370953	1.33E-171
PRAD	Cell metabolism gene	MRPL23	NME3	0.872252818	2.29E-172
PRAD	Cell metabolism gene	MRPL23	PGLS	0.904711151	3.21E-205
PRAD	Cell metabolism gene	MRPL23	POLR2I	0.915763704	3.30E-219
PRAD	CGC	MRPL23	MGMT	0.808585149	2.49E-128
PRAD	CGC	MRPL23	MAP2K2	0.847038246	1.56E-152
PRAD	CGC	MRPL23	HRAS	0.857165392	4.88E-160
PRAD	CGC	MRPL23	ASPSCR1	0.861419141	2.30E-163
PRAD	Epifactor	MRPL23	EXOSC4	0.812331061	1.94E-130
PRAD	Epifactor	MRPL23	INO80E	0.818531462	4.94E-134
PRAD	Epifactor	MRPL23	PRPF31	0.818598973	4.51E-134
PRAD	Epifactor	MRPL23	PPP4C	0.819108983	2.25E-134
PRAD	Epifactor	MRPL23	DMAP1	0.833832118	1.59E-143
PRAD	Epifactor	MRPL23	RUVBL2	0.839913586	1.43E-147
PRAD	Epifactor	MRPL23	SIRT6	0.846028706	8.17E-152
PRAD	Epifactor	MRPL23	TAF10	0.860442098	1.36E-162
PRAD	Epifactor	MRPL23	ZNHIT1	0.870143593	1.50E-170
PRAD	IUPHAR	MRPL23	DPP7	0.801703924	1.41E-124
PRAD	IUPHAR	MRPL23	PMVK	0.812728335	1.15E-130
PRAD	IUPHAR	MRPL23	MPST	0.817257259	2.78E-133
PRAD	IUPHAR	MRPL23	PTGES2	0.822720398	1.54E-136
PRAD	IUPHAR	MRPL23	NR2F6	0.841370279	1.45E-148
PRAD	IUPHAR	MRPL23	SIRT6	0.846028706	8.17E-152
PRAD	IUPHAR	MRPL23	MAP2K2	0.847038246	1.56E-152
PRAD	IUPHAR	MRPL23	CSNK2B	0.854735341	3.48E-158
PRAD	IUPHAR	MRPL23	HRAS	0.857165392	4.88E-160
PRAD	Kinase	MRPL23	FASTK	0.831797922	3.30E-142
PRAD	Kinase	MRPL23	MAP2K2	0.847038246	1.56E-152
PRAD	TF	MRPL23	DRAP1	0.803104427	2.50E-125
PRAD	TF	MRPL23	ZNF580	0.803675319	1.23E-125
PRAD	TF	MRPL23	ZNF787	0.810075977	3.66E-129
PRAD	TF	MRPL23	ZNF205	0.81992308	7.38E-135
PRAD	TF	MRPL23	ZNF358	0.821651217	6.80E-136
PRAD	TF	MRPL23	THAP7	0.822260927	2.92E-136
PRAD	TF	MRPL23	ZNF444	0.829967	4.88E-141
PRAD	TF	MRPL23	ZNF688	0.838414225	1.47E-146
PRAD	TF	MRPL23	NR2F6	0.841370279	1.45E-148
PRAD	TF	MRPL23	ZNF579	0.84173835	8.10E-149
PRAD	TF	MRPL23	THAP3	0.851922125	4.41E-156
PRAD	TF	MRPL23	ZNF524	0.889388315	1.98E-188
PRAD	TSG	MRPL23	STUB1	0.830168693	3.63E-141
PRAD	TSG	MRPL23	SIRT6	0.846028706	8.17E-152
PRAD	TSG	MRPL23	TSSC4	0.855306575	1.28E-158
PRAD	TSG	MRPL23	GADD45GIP1	0.914158356	4.64E-217
READ	TSG	MRPL23	GADD45GIP1	0.809747073	1.37E-25
TGCT	Cell metabolism gene	MRPL23	PSMD13	0.815498208	2.09E-38
TGCT	CGC	MRPL23	HRAS	0.82720702	2.17E-40
TGCT	Epifactor	MRPL23	TAF10	0.823461418	9.69E-40
TGCT	IUPHAR	MRPL23	HRAS	0.82720702	2.17E-40
THCA	Cell metabolism gene	MRPL23	POLR2L	0.801230537	3.07E-129
THCA	Cell metabolism gene	MRPL23	PSMB1	0.80130545	2.79E-129
THCA	Cell metabolism gene	MRPL23	APRT	0.801311481	2.76E-129
THCA	Cell metabolism gene	MRPL23	PSMB7	0.802544374	5.69E-130
THCA	Cell metabolism gene	MRPL23	PSMC3	0.814669516	5.43E-137
THCA	Cell metabolism gene	MRPL23	PFDN5	0.816654504	3.44E-138
THCA	Cell metabolism gene	MRPL23	NT5C	0.818363256	3.11E-139
THCA	Cell metabolism gene	MRPL23	EXOSC4	0.81914154	1.03E-139
THCA	Cell metabolism gene	MRPL23	SNRPD2	0.819939101	3.31E-140
THCA	Cell metabolism gene	MRPL23	POLR2J	0.826719696	1.68E-144
THCA	Cell metabolism gene	MRPL23	PHPT1	0.8341614	1.96E-149
THCA	Cell metabolism gene	MRPL23	PSMB3	0.837455902	1.07E-151
THCA	Cell metabolism gene	MRPL23	PFDN6	0.849352069	2.60E-160
THCA	Cell metabolism gene	MRPL23	PGLS	0.857367411	1.51E-166
THCA	Cell metabolism gene	MRPL23	POLR2I	0.876636453	3.04E-183
THCA	Cell metabolism gene	MRPL23	DPM3	0.880792168	3.26E-187
THCA	Cell metabolism gene	MRPL23	FAU	0.883734916	4.08E-190
THCA	CGC	MRPL23	ASPSCR1	0.803879893	1.01E-130
THCA	CGC	MRPL23	MAP2K2	0.819721683	4.52E-140
THCA	CGC	MRPL23	HRAS	0.849949686	9.17E-161
THCA	Epifactor	MRPL23	RUVBL2	0.800782273	5.43E-129
THCA	Epifactor	MRPL23	HMG20B	0.811664823	3.32E-135
THCA	Epifactor	MRPL23	EXOSC4	0.81914154	1.03E-139
THCA	Epifactor	MRPL23	BRMS1	0.828131922	2.03E-145
THCA	Epifactor	MRPL23	ZNHIT1	0.860148951	8.41E-169
THCA	Epifactor	MRPL23	TAF10	0.89087356	1.71E-197
THCA	IUPHAR	MRPL23	PSMB1	0.80130545	2.79E-129
THCA	IUPHAR	MRPL23	NT5C	0.818363256	3.11E-139
THCA	IUPHAR	MRPL23	MAP2K2	0.819721683	4.52E-140
THCA	IUPHAR	MRPL23	HRAS	0.849949686	9.17E-161
THCA	Kinase	MRPL23	MAP2K2	0.819721683	4.52E-140
THCA	TF	MRPL23	THAP7	0.809193442	9.28E-134
THCA	TF	MRPL23	HMG20B	0.811664823	3.32E-135
THCA	TF	MRPL23	ZNF524	0.812750561	7.58E-136
THCA	TF	MRPL23	ZNF428	0.829922063	1.36E-146
THCA	TF	MRPL23	ZNF688	0.832291004	3.59E-148
THCA	TSG	MRPL23	BRMS1	0.828131922	2.03E-145
THCA	TSG	MRPL23	AIP	0.828163096	1.94E-145
THCA	TSG	MRPL23	GADD45GIP1	0.921677917	1.46E-236
THYM	Cell metabolism gene	MRPL23	NME1	0.800891207	1.70E-28
THYM	Cell metabolism gene	MRPL23	HMOX2	0.802323875	1.15E-28
THYM	Cell metabolism gene	MRPL23	POLR3K	0.80249391	1.10E-28
THYM	Cell metabolism gene	MRPL23	HSD17B10	0.803122299	9.29E-29
THYM	Cell metabolism gene	MRPL23	MMAB	0.803283553	8.89E-29
THYM	Cell metabolism gene	MRPL23	PPCDC	0.805014225	5.53E-29
THYM	Cell metabolism gene	MRPL23	SNRPE	0.805890796	4.34E-29
THYM	Cell metabolism gene	MRPL23	LSM3	0.807767528	2.57E-29
THYM	Cell metabolism gene	MRPL23	NT5C	0.808817331	1.92E-29
THYM	Cell metabolism gene	MRPL23	POLA2	0.813155721	5.55E-30
THYM	Cell metabolism gene	MRPL23	LSM5	0.813695964	4.75E-30
THYM	Cell metabolism gene	MRPL23	PSMB6	0.814366951	3.91E-30
THYM	Cell metabolism gene	MRPL23	MTMR14	0.814392248	3.88E-30
THYM	Cell metabolism gene	MRPL23	ATP5G1	0.816347568	2.19E-30
THYM	Cell metabolism gene	MRPL23	TOMM22	0.817870707	1.39E-30
THYM	Cell metabolism gene	MRPL23	TSTA3	0.821145305	5.20E-31
THYM	Cell metabolism gene	MRPL23	SEC61G	0.821515593	4.65E-31
THYM	Cell metabolism gene	MRPL23	PTGES2	0.821622187	4.50E-31
THYM	Cell metabolism gene	MRPL23	PFDN6	0.821770568	4.30E-31
THYM	Cell metabolism gene	MRPL23	WBSCR22	0.822008942	4.00E-31
THYM	Cell metabolism gene	MRPL23	DGKZ	0.822328327	3.63E-31
THYM	Cell metabolism gene	MRPL23	IDH3G	0.822786028	3.15E-31
THYM	Cell metabolism gene	MRPL23	PSMC1	0.82430223	1.97E-31
THYM	Cell metabolism gene	MRPL23	SNRPF	0.824890455	1.65E-31
THYM	Cell metabolism gene	MRPL23	PSMA4	0.82668993	9.37E-32
THYM	Cell metabolism gene	MRPL23	DOHH	0.82745191	7.37E-32
THYM	Cell metabolism gene	MRPL23	LCMT1	0.830839819	2.50E-32
THYM	Cell metabolism gene	MRPL23	NANS	0.831174418	2.24E-32
THYM	Cell metabolism gene	MRPL23	UROS	0.831465593	2.04E-32
THYM	Cell metabolism gene	MRPL23	SNRPB	0.832025102	1.70E-32
THYM	Cell metabolism gene	MRPL23	UROD	0.835388829	5.61E-33
THYM	Cell metabolism gene	MRPL23	PSME1	0.837924166	2.40E-33
THYM	Cell metabolism gene	MRPL23	POLD4	0.839375202	1.46E-33
THYM	Cell metabolism gene	MRPL23	SNRPD1	0.839629993	1.34E-33
THYM	Cell metabolism gene	MRPL23	PCYT2	0.839959686	1.20E-33
THYM	Cell metabolism gene	MRPL23	PAFAH1B3	0.840420688	1.02E-33
THYM	Cell metabolism gene	MRPL23	PSME2	0.840440817	1.01E-33
THYM	Cell metabolism gene	MRPL23	HMBS	0.841371451	7.35E-34
THYM	Cell metabolism gene	MRPL23	TBCB	0.842127908	5.65E-34
THYM	Cell metabolism gene	MRPL23	GALK1	0.84414651	2.78E-34
THYM	Cell metabolism gene	MRPL23	ALG3	0.844278835	2.65E-34
THYM	Cell metabolism gene	MRPL23	SRM	0.845039664	2.03E-34
THYM	Cell metabolism gene	MRPL23	GMPPA	0.846019744	1.43E-34
THYM	Cell metabolism gene	MRPL23	TIMM17B	0.84767449	7.87E-35
THYM	Cell metabolism gene	MRPL23	OAZ1	0.850707956	2.59E-35
THYM	Cell metabolism gene	MRPL23	MIF	0.851823406	1.71E-35
THYM	Cell metabolism gene	MRPL23	GEMIN7	0.853753164	8.26E-36
THYM	Cell metabolism gene	MRPL23	GEMIN6	0.855727927	3.89E-36
THYM	Cell metabolism gene	MRPL23	TALDO1	0.856460417	2.93E-36
THYM	Cell metabolism gene	MRPL23	DTYMK	0.856940866	2.43E-36
THYM	Cell metabolism gene	MRPL23	DPM3	0.857565498	1.91E-36
THYM	Cell metabolism gene	MRPL23	PSMC5	0.857977994	1.62E-36
THYM	Cell metabolism gene	MRPL23	PSMD4	0.858474098	1.34E-36
THYM	Cell metabolism gene	MRPL23	DGUOK	0.858774245	1.19E-36
THYM	Cell metabolism gene	MRPL23	SSR2	0.86060123	5.76E-37
THYM	Cell metabolism gene	MRPL23	GFER	0.861309349	4.34E-37
THYM	Cell metabolism gene	MRPL23	SNRPD3	0.863508199	1.78E-37
THYM	Cell metabolism gene	MRPL23	POLR2F	0.864775196	1.06E-37
THYM	Cell metabolism gene	MRPL23	FPGS	0.867107854	4.00E-38
THYM	Cell metabolism gene	MRPL23	PGP	0.867785513	3.01E-38
THYM	Cell metabolism gene	MRPL23	ITPA	0.868336117	2.38E-38
THYM	Cell metabolism gene	MRPL23	SMPD2	0.872383035	4.15E-39
THYM	Cell metabolism gene	MRPL23	PMPCA	0.872610604	3.75E-39
THYM	Cell metabolism gene	MRPL23	EXOSC5	0.872656877	3.68E-39
THYM	Cell metabolism gene	MRPL23	PSMB10	0.872956279	3.22E-39
THYM	Cell metabolism gene	MRPL23	LSM2	0.872969881	3.20E-39
THYM	Cell metabolism gene	MRPL23	EBP	0.878104925	3.16E-40
THYM	Cell metabolism gene	MRPL23	TOMM40	0.878165787	3.07E-40
THYM	Cell metabolism gene	MRPL23	PSMB1	0.881502407	6.43E-41
THYM	Cell metabolism gene	MRPL23	MVD	0.881630343	6.05E-41
THYM	Cell metabolism gene	MRPL23	POLR2J	0.881784678	5.62E-41
THYM	Cell metabolism gene	MRPL23	LSM4	0.883168848	2.89E-41
THYM	Cell metabolism gene	MRPL23	POLD2	0.884476113	1.53E-41
THYM	Cell metabolism gene	MRPL23	MTX1	0.88607664	6.97E-42
THYM	Cell metabolism gene	MRPL23	DPM2	0.886488344	5.68E-42
THYM	Cell metabolism gene	MRPL23	GUK1	0.888500853	2.07E-42
THYM	Cell metabolism gene	MRPL23	PHKG2	0.889909368	1.01E-42
THYM	Cell metabolism gene	MRPL23	TIMM10	0.890017672	9.52E-43
THYM	Cell metabolism gene	MRPL23	PFDN5	0.896974679	2.33E-44
THYM	Cell metabolism gene	MRPL23	POLR2I	0.897868182	1.42E-44
THYM	Cell metabolism gene	MRPL23	APRT	0.905765206	1.45E-46
THYM	Cell metabolism gene	MRPL23	POLR2H	0.907249021	5.84E-47
THYM	Cell metabolism gene	MRPL23	PGLS	0.908792081	2.24E-47
THYM	Cell metabolism gene	MRPL23	PSMD13	0.911422315	4.19E-48
THYM	Cell metabolism gene	MRPL23	PSMB7	0.915580506	2.65E-49
THYM	Cell metabolism gene	MRPL23	SLC27A5	0.91883286	2.77E-50
THYM	Cell metabolism gene	MRPL23	EXOSC4	0.919407796	1.84E-50
THYM	Cell metabolism gene	MRPL23	PSMC3	0.919566052	1.64E-50
THYM	Cell metabolism gene	MRPL23	ACOT8	0.929329128	9.37E-54
THYM	Cell metabolism gene	MRPL23	TIMM50	0.932839199	4.90E-55
THYM	Cell metabolism gene	MRPL23	FAU	0.937031585	1.16E-56
THYM	Cell metabolism gene	MRPL23	TIMM8B	0.940244824	5.52E-58
THYM	Cell metabolism gene	MRPL23	TIMM13	0.941211536	2.13E-58
THYM	Cell metabolism gene	MRPL23	PSMB3	0.944344277	8.77E-60
THYM	Cell metabolism gene	MRPL23	SNRPD2	0.945893304	1.69E-60
THYM	CGC	MRPL23	MGMT	0.835423226	5.55E-33
THYM	CGC	MRPL23	MAP2K2	0.842577267	4.83E-34
THYM	CGC	MRPL23	ASPSCR1	0.868063573	2.67E-38
THYM	CGC	MRPL23	SDHAF2	0.87580754	9.02E-40
THYM	CGC	MRPL23	RBM10	0.882832366	3.40E-41
THYM	CGC	MRPL23	TFPT	0.911479739	4.03E-48
THYM	Epifactor	MRPL23	PPM1G	0.804748769	5.95E-29
THYM	Epifactor	MRPL23	INO80B	0.807030292	3.16E-29
THYM	Epifactor	MRPL23	SS18L2	0.807846701	2.52E-29
THYM	Epifactor	MRPL23	PAF1	0.810812847	1.09E-29
THYM	Epifactor	MRPL23	PELP1	0.822573362	3.36E-31
THYM	Epifactor	MRPL23	RRP8	0.833207551	1.15E-32
THYM	Epifactor	MRPL23	LAS1L	0.845857592	1.51E-34
THYM	Epifactor	MRPL23	DMAP1	0.847586998	8.12E-35
THYM	Epifactor	MRPL23	CXXC1	0.851882016	1.67E-35
THYM	Epifactor	MRPL23	ZGPAT	0.85261089	1.27E-35
THYM	Epifactor	MRPL23	PRMT1	0.860444524	6.13E-37
THYM	Epifactor	MRPL23	EXOSC5	0.872656877	3.68E-39
THYM	Epifactor	MRPL23	C17orf49	0.875635146	9.75E-40
THYM	Epifactor	MRPL23	CCDC101	0.886418392	5.88E-42
THYM	Epifactor	MRPL23	INO80E	0.903289393	6.36E-46
THYM	Epifactor	MRPL23	ZNHIT1	0.906160831	1.14E-46
THYM	Epifactor	MRPL23	FBL	0.906244269	1.08E-46
THYM	Epifactor	MRPL23	MBD3	0.906257971	1.07E-46
THYM	Epifactor	MRPL23	RUVBL2	0.90639825	9.84E-47
THYM	Epifactor	MRPL23	NOC2L	0.907594565	4.72E-47
THYM	Epifactor	MRPL23	TFPT	0.911479739	4.03E-48
THYM	Epifactor	MRPL23	PPP4C	0.912029725	2.82E-48
THYM	Epifactor	MRPL23	PRPF31	0.912610735	1.93E-48
THYM	Epifactor	MRPL23	EXOSC4	0.919407796	1.84E-50
THYM	Epifactor	MRPL23	SIRT6	0.9439002	1.39E-59
THYM	Epifactor	MRPL23	BRMS1	0.946074062	1.39E-60
THYM	Epifactor	MRPL23	TAF10	0.951762415	2.05E-63
THYM	IUPHAR	MRPL23	HMOX2	0.802323875	1.15E-28
THYM	IUPHAR	MRPL23	ATG4B	0.802484864	1.11E-28
THYM	IUPHAR	MRPL23	FKBP1A	0.805412088	4.96E-29
THYM	IUPHAR	MRPL23	NT5C	0.808817331	1.92E-29
THYM	IUPHAR	MRPL23	DPP7	0.810841231	1.08E-29
THYM	IUPHAR	MRPL23	PSMB6	0.814366951	3.91E-30
THYM	IUPHAR	MRPL23	MAP3K11	0.814906931	3.34E-30
THYM	IUPHAR	MRPL23	MFSD2B	0.818196656	1.26E-30
THYM	IUPHAR	MRPL23	ATP6V0B	0.820803468	5.77E-31
THYM	IUPHAR	MRPL23	MPDU1	0.82128362	4.99E-31
THYM	IUPHAR	MRPL23	PTGES2	0.821622187	4.50E-31
THYM	IUPHAR	MRPL23	PPIA	0.829344631	4.04E-32
THYM	IUPHAR	MRPL23	MMP24	0.833378751	1.09E-32
THYM	IUPHAR	MRPL23	SIRT3	0.8396432	1.33E-33
THYM	IUPHAR	MRPL23	MAP2K2	0.842577267	4.83E-34
THYM	IUPHAR	MRPL23	EGLN2	0.850122598	3.21E-35
THYM	IUPHAR	MRPL23	PRMT1	0.860444524	6.13E-37
THYM	IUPHAR	MRPL23	SMPD2	0.872383035	4.15E-39
THYM	IUPHAR	MRPL23	PSMB1	0.881502407	6.43E-41
THYM	IUPHAR	MRPL23	MVD	0.881630343	6.05E-41
THYM	IUPHAR	MRPL23	PHKG2	0.889909368	1.01E-42
THYM	IUPHAR	MRPL23	SLC27A5	0.91883286	2.77E-50
THYM	IUPHAR	MRPL23	SIRT6	0.9439002	1.39E-59
THYM	Kinase	MRPL23	ADCK4	0.807610234	2.69E-29
THYM	Kinase	MRPL23	MAP3K11	0.814906931	3.34E-30
THYM	Kinase	MRPL23	MAP2K2	0.842577267	4.83E-34
THYM	Kinase	MRPL23	PHKG2	0.889909368	1.01E-42
THYM	TF	MRPL23	ZNF691	0.801083399	1.61E-28
THYM	TF	MRPL23	PIN1	0.806075284	4.12E-29
THYM	TF	MRPL23	ZNF408	0.814155412	4.15E-30
THYM	TF	MRPL23	E4F1	0.814485644	3.77E-30
THYM	TF	MRPL23	USF1	0.832635888	1.39E-32
THYM	TF	MRPL23	ETV2	0.833789346	9.54E-33
THYM	TF	MRPL23	ZNF524	0.836198741	4.28E-33
THYM	TF	MRPL23	ZNF32	0.839287914	1.51E-33
THYM	TF	MRPL23	THYN1	0.840098162	1.14E-33
THYM	TF	MRPL23	ZBTB48	0.847655807	7.92E-35
THYM	TF	MRPL23	IRF3	0.848609116	5.60E-35
THYM	TF	MRPL23	REXO4	0.851323812	2.06E-35
THYM	TF	MRPL23	CXXC1	0.851882016	1.67E-35
THYM	TF	MRPL23	ZGPAT	0.85261089	1.27E-35
THYM	TF	MRPL23	ZNF581	0.852795028	1.19E-35
THYM	TF	MRPL23	GLI4	0.855041443	5.06E-36
THYM	TF	MRPL23	THAP7	0.861953807	3.34E-37
THYM	TF	MRPL23	ZNF444	0.863937727	1.49E-37
THYM	TF	MRPL23	AKAP8L	0.864905	1.00E-37
THYM	TF	MRPL23	ZNF511	0.864918661	9.97E-38
THYM	TF	MRPL23	DRAP1	0.868121478	2.61E-38
THYM	TF	MRPL23	RBCK1	0.87100055	7.59E-39
THYM	TF	MRPL23	ZNF668	0.871803674	5.35E-39
THYM	TF	MRPL23	THAP3	0.88332524	2.68E-41
THYM	TF	MRPL23	ZNF688	0.894350137	9.75E-44
THYM	TF	MRPL23	ZNF428	0.898829995	8.30E-45
THYM	TF	MRPL23	MBD3	0.906257971	1.07E-46
THYM	TF	MRPL23	ZNF787	0.915670486	2.49E-49
THYM	TSG	MRPL23	NME1	0.800891207	1.70E-28
THYM	TSG	MRPL23	TUSC2	0.804456573	6.45E-29
THYM	TSG	MRPL23	PHB	0.804696127	6.04E-29
THYM	TSG	MRPL23	PIN1	0.806075284	4.12E-29
THYM	TSG	MRPL23	MAD1L1	0.80953667	1.56E-29
THYM	TSG	MRPL23	STUB1	0.811792599	8.22E-30
THYM	TSG	MRPL23	PFN1	0.825269838	1.46E-31
THYM	TSG	MRPL23	HTRA2	0.829465094	3.88E-32
THYM	TSG	MRPL23	PARK7	0.837524598	2.74E-33
THYM	TSG	MRPL23	AIP	0.839405368	1.45E-33
THYM	TSG	MRPL23	SIRT3	0.8396432	1.33E-33
THYM	TSG	MRPL23	GABARAP	0.840645736	9.45E-34
THYM	TSG	MRPL23	ZBTB48	0.847655807	7.92E-35
THYM	TSG	MRPL23	IRF3	0.848609116	5.60E-35
THYM	TSG	MRPL23	PYCARD	0.852053809	1.57E-35
THYM	TSG	MRPL23	GLTSCR2	0.865578723	7.58E-38
THYM	TSG	MRPL23	ZNF668	0.871803674	5.35E-39
THYM	TSG	MRPL23	GNB2L1	0.872268545	4.36E-39
THYM	TSG	MRPL23	NPRL2	0.906261011	1.07E-46
THYM	TSG	MRPL23	GADD45GIP1	0.933096004	3.92E-55
THYM	TSG	MRPL23	TSSC4	0.937726191	6.09E-57
THYM	TSG	MRPL23	SIRT6	0.9439002	1.39E-59
THYM	TSG	MRPL23	BRMS1	0.946074062	1.39E-60
UCEC	Cell metabolism gene	MRPL23	APRT	0.807598562	1.60E-47
UCEC	CGC	MRPL23	HRAS	0.840721207	6.42E-55
UCEC	Epifactor	MRPL23	TAF10	0.850018942	2.64E-57
UCEC	IUPHAR	MRPL23	HRAS	0.840721207	6.42E-55
UCEC	TSG	MRPL23	GADD45GIP1	0.814416231	6.37E-49
UCS	Cell metabolism gene	MRPL23	NME1	0.800891207	1.70E-28
UCS	Cell metabolism gene	MRPL23	HMOX2	0.802323875	1.15E-28
UCS	Cell metabolism gene	MRPL23	POLR3K	0.80249391	1.10E-28
UCS	Cell metabolism gene	MRPL23	HSD17B10	0.803122299	9.29E-29
UCS	Cell metabolism gene	MRPL23	MMAB	0.803283553	8.89E-29
UCS	Cell metabolism gene	MRPL23	PPCDC	0.805014225	5.53E-29
UCS	Cell metabolism gene	MRPL23	SNRPE	0.805890796	4.34E-29
UCS	Cell metabolism gene	MRPL23	LSM3	0.807767528	2.57E-29
UCS	Cell metabolism gene	MRPL23	NT5C	0.808817331	1.92E-29
UCS	Cell metabolism gene	MRPL23	POLA2	0.813155721	5.55E-30
UCS	Cell metabolism gene	MRPL23	LSM5	0.813695964	4.75E-30
UCS	Cell metabolism gene	MRPL23	PSMB6	0.814366951	3.91E-30
UCS	Cell metabolism gene	MRPL23	MTMR14	0.814392248	3.88E-30
UCS	Cell metabolism gene	MRPL23	ATP5G1	0.816347568	2.19E-30
UCS	Cell metabolism gene	MRPL23	TOMM22	0.817870707	1.39E-30
UCS	Cell metabolism gene	MRPL23	TSTA3	0.821145305	5.20E-31
UCS	Cell metabolism gene	MRPL23	SEC61G	0.821515593	4.65E-31
UCS	Cell metabolism gene	MRPL23	PTGES2	0.821622187	4.50E-31
UCS	Cell metabolism gene	MRPL23	PFDN6	0.821770568	4.30E-31
UCS	Cell metabolism gene	MRPL23	WBSCR22	0.822008942	4.00E-31
UCS	Cell metabolism gene	MRPL23	DGKZ	0.822328327	3.63E-31
UCS	Cell metabolism gene	MRPL23	IDH3G	0.822786028	3.15E-31
UCS	Cell metabolism gene	MRPL23	PSMC1	0.82430223	1.97E-31
UCS	Cell metabolism gene	MRPL23	SNRPF	0.824890455	1.65E-31
UCS	Cell metabolism gene	MRPL23	PSMA4	0.82668993	9.37E-32
UCS	Cell metabolism gene	MRPL23	DOHH	0.82745191	7.37E-32
UCS	Cell metabolism gene	MRPL23	LCMT1	0.830839819	2.50E-32
UCS	Cell metabolism gene	MRPL23	NANS	0.831174418	2.24E-32
UCS	Cell metabolism gene	MRPL23	UROS	0.831465593	2.04E-32
UCS	Cell metabolism gene	MRPL23	SNRPB	0.832025102	1.70E-32
UCS	Cell metabolism gene	MRPL23	UROD	0.835388829	5.61E-33
UCS	Cell metabolism gene	MRPL23	PSME1	0.837924166	2.40E-33
UCS	Cell metabolism gene	MRPL23	POLD4	0.839375202	1.46E-33
UCS	Cell metabolism gene	MRPL23	SNRPD1	0.839629993	1.34E-33
UCS	Cell metabolism gene	MRPL23	PCYT2	0.839959686	1.20E-33
UCS	Cell metabolism gene	MRPL23	PAFAH1B3	0.840420688	1.02E-33
UCS	Cell metabolism gene	MRPL23	PSME2	0.840440817	1.01E-33
UCS	Cell metabolism gene	MRPL23	HMBS	0.841371451	7.35E-34
UCS	Cell metabolism gene	MRPL23	TBCB	0.842127908	5.65E-34
UCS	Cell metabolism gene	MRPL23	GALK1	0.84414651	2.78E-34
UCS	Cell metabolism gene	MRPL23	ALG3	0.844278835	2.65E-34
UCS	Cell metabolism gene	MRPL23	SRM	0.845039664	2.03E-34
UCS	Cell metabolism gene	MRPL23	GMPPA	0.846019744	1.43E-34
UCS	Cell metabolism gene	MRPL23	TIMM17B	0.84767449	7.87E-35
UCS	Cell metabolism gene	MRPL23	OAZ1	0.850707956	2.59E-35
UCS	Cell metabolism gene	MRPL23	MIF	0.851823406	1.71E-35
UCS	Cell metabolism gene	MRPL23	GEMIN7	0.853753164	8.26E-36
UCS	Cell metabolism gene	MRPL23	GEMIN6	0.855727927	3.89E-36
UCS	Cell metabolism gene	MRPL23	TALDO1	0.856460417	2.93E-36
UCS	Cell metabolism gene	MRPL23	DTYMK	0.856940866	2.43E-36
UCS	Cell metabolism gene	MRPL23	DPM3	0.857565498	1.91E-36
UCS	Cell metabolism gene	MRPL23	PSMC5	0.857977994	1.62E-36
UCS	Cell metabolism gene	MRPL23	PSMD4	0.858474098	1.34E-36
UCS	Cell metabolism gene	MRPL23	DGUOK	0.858774245	1.19E-36
UCS	Cell metabolism gene	MRPL23	SSR2	0.86060123	5.76E-37
UCS	Cell metabolism gene	MRPL23	GFER	0.861309349	4.34E-37
UCS	Cell metabolism gene	MRPL23	SNRPD3	0.863508199	1.78E-37
UCS	Cell metabolism gene	MRPL23	POLR2F	0.864775196	1.06E-37
UCS	Cell metabolism gene	MRPL23	FPGS	0.867107854	4.00E-38
UCS	Cell metabolism gene	MRPL23	PGP	0.867785513	3.01E-38
UCS	Cell metabolism gene	MRPL23	ITPA	0.868336117	2.38E-38
UCS	Cell metabolism gene	MRPL23	SMPD2	0.872383035	4.15E-39
UCS	Cell metabolism gene	MRPL23	PMPCA	0.872610604	3.75E-39
UCS	Cell metabolism gene	MRPL23	EXOSC5	0.872656877	3.68E-39
UCS	Cell metabolism gene	MRPL23	PSMB10	0.872956279	3.22E-39
UCS	Cell metabolism gene	MRPL23	LSM2	0.872969881	3.20E-39
UCS	Cell metabolism gene	MRPL23	EBP	0.878104925	3.16E-40
UCS	Cell metabolism gene	MRPL23	TOMM40	0.878165787	3.07E-40
UCS	Cell metabolism gene	MRPL23	PSMB1	0.881502407	6.43E-41
UCS	Cell metabolism gene	MRPL23	MVD	0.881630343	6.05E-41
UCS	Cell metabolism gene	MRPL23	POLR2J	0.881784678	5.62E-41
UCS	Cell metabolism gene	MRPL23	LSM4	0.883168848	2.89E-41
UCS	Cell metabolism gene	MRPL23	POLD2	0.884476113	1.53E-41
UCS	Cell metabolism gene	MRPL23	MTX1	0.88607664	6.97E-42
UCS	Cell metabolism gene	MRPL23	DPM2	0.886488344	5.68E-42
UCS	Cell metabolism gene	MRPL23	GUK1	0.888500853	2.07E-42
UCS	Cell metabolism gene	MRPL23	PHKG2	0.889909368	1.01E-42
UCS	Cell metabolism gene	MRPL23	TIMM10	0.890017672	9.52E-43
UCS	Cell metabolism gene	MRPL23	PFDN5	0.896974679	2.33E-44
UCS	Cell metabolism gene	MRPL23	POLR2I	0.897868182	1.42E-44
UCS	Cell metabolism gene	MRPL23	APRT	0.905765206	1.45E-46
UCS	Cell metabolism gene	MRPL23	POLR2H	0.907249021	5.84E-47
UCS	Cell metabolism gene	MRPL23	PGLS	0.908792081	2.24E-47
UCS	Cell metabolism gene	MRPL23	PSMD13	0.911422315	4.19E-48
UCS	Cell metabolism gene	MRPL23	PSMB7	0.915580506	2.65E-49
UCS	Cell metabolism gene	MRPL23	SLC27A5	0.91883286	2.77E-50
UCS	Cell metabolism gene	MRPL23	EXOSC4	0.919407796	1.84E-50
UCS	Cell metabolism gene	MRPL23	PSMC3	0.919566052	1.64E-50
UCS	Cell metabolism gene	MRPL23	ACOT8	0.929329128	9.37E-54
UCS	Cell metabolism gene	MRPL23	TIMM50	0.932839199	4.90E-55
UCS	Cell metabolism gene	MRPL23	FAU	0.937031585	1.16E-56
UCS	Cell metabolism gene	MRPL23	TIMM8B	0.940244824	5.52E-58
UCS	Cell metabolism gene	MRPL23	TIMM13	0.941211536	2.13E-58
UCS	Cell metabolism gene	MRPL23	PSMB3	0.944344277	8.77E-60
UCS	Cell metabolism gene	MRPL23	SNRPD2	0.945893304	1.69E-60
UCS	CGC	MRPL23	MGMT	0.835423226	5.55E-33
UCS	CGC	MRPL23	MAP2K2	0.842577267	4.83E-34
UCS	CGC	MRPL23	ASPSCR1	0.868063573	2.67E-38
UCS	CGC	MRPL23	SDHAF2	0.87580754	9.02E-40
UCS	CGC	MRPL23	RBM10	0.882832366	3.40E-41
UCS	CGC	MRPL23	TFPT	0.911479739	4.03E-48
UCS	Epifactor	MRPL23	PPM1G	0.804748769	5.95E-29
UCS	Epifactor	MRPL23	INO80B	0.807030292	3.16E-29
UCS	Epifactor	MRPL23	SS18L2	0.807846701	2.52E-29
UCS	Epifactor	MRPL23	PAF1	0.810812847	1.09E-29
UCS	Epifactor	MRPL23	PELP1	0.822573362	3.36E-31
UCS	Epifactor	MRPL23	RRP8	0.833207551	1.15E-32
UCS	Epifactor	MRPL23	LAS1L	0.845857592	1.51E-34
UCS	Epifactor	MRPL23	DMAP1	0.847586998	8.12E-35
UCS	Epifactor	MRPL23	CXXC1	0.851882016	1.67E-35
UCS	Epifactor	MRPL23	ZGPAT	0.85261089	1.27E-35
UCS	Epifactor	MRPL23	PRMT1	0.860444524	6.13E-37
UCS	Epifactor	MRPL23	EXOSC5	0.872656877	3.68E-39
UCS	Epifactor	MRPL23	C17orf49	0.875635146	9.75E-40
UCS	Epifactor	MRPL23	CCDC101	0.886418392	5.88E-42
UCS	Epifactor	MRPL23	INO80E	0.903289393	6.36E-46
UCS	Epifactor	MRPL23	ZNHIT1	0.906160831	1.14E-46
UCS	Epifactor	MRPL23	FBL	0.906244269	1.08E-46
UCS	Epifactor	MRPL23	MBD3	0.906257971	1.07E-46
UCS	Epifactor	MRPL23	RUVBL2	0.90639825	9.84E-47
UCS	Epifactor	MRPL23	NOC2L	0.907594565	4.72E-47
UCS	Epifactor	MRPL23	TFPT	0.911479739	4.03E-48
UCS	Epifactor	MRPL23	PPP4C	0.912029725	2.82E-48
UCS	Epifactor	MRPL23	PRPF31	0.912610735	1.93E-48
UCS	Epifactor	MRPL23	EXOSC4	0.919407796	1.84E-50
UCS	Epifactor	MRPL23	SIRT6	0.9439002	1.39E-59
UCS	Epifactor	MRPL23	BRMS1	0.946074062	1.39E-60
UCS	Epifactor	MRPL23	TAF10	0.951762415	2.05E-63
UCS	IUPHAR	MRPL23	HMOX2	0.802323875	1.15E-28
UCS	IUPHAR	MRPL23	ATG4B	0.802484864	1.11E-28
UCS	IUPHAR	MRPL23	FKBP1A	0.805412088	4.96E-29
UCS	IUPHAR	MRPL23	NT5C	0.808817331	1.92E-29
UCS	IUPHAR	MRPL23	DPP7	0.810841231	1.08E-29
UCS	IUPHAR	MRPL23	PSMB6	0.814366951	3.91E-30
UCS	IUPHAR	MRPL23	MAP3K11	0.814906931	3.34E-30
UCS	IUPHAR	MRPL23	MFSD2B	0.818196656	1.26E-30
UCS	IUPHAR	MRPL23	ATP6V0B	0.820803468	5.77E-31
UCS	IUPHAR	MRPL23	MPDU1	0.82128362	4.99E-31
UCS	IUPHAR	MRPL23	PTGES2	0.821622187	4.50E-31
UCS	IUPHAR	MRPL23	PPIA	0.829344631	4.04E-32
UCS	IUPHAR	MRPL23	MMP24	0.833378751	1.09E-32
UCS	IUPHAR	MRPL23	SIRT3	0.8396432	1.33E-33
UCS	IUPHAR	MRPL23	MAP2K2	0.842577267	4.83E-34
UCS	IUPHAR	MRPL23	EGLN2	0.850122598	3.21E-35
UCS	IUPHAR	MRPL23	PRMT1	0.860444524	6.13E-37
UCS	IUPHAR	MRPL23	SMPD2	0.872383035	4.15E-39
UCS	IUPHAR	MRPL23	PSMB1	0.881502407	6.43E-41
UCS	IUPHAR	MRPL23	MVD	0.881630343	6.05E-41
UCS	IUPHAR	MRPL23	PHKG2	0.889909368	1.01E-42
UCS	IUPHAR	MRPL23	SLC27A5	0.91883286	2.77E-50
UCS	IUPHAR	MRPL23	SIRT6	0.9439002	1.39E-59
UCS	Kinase	MRPL23	ADCK4	0.807610234	2.69E-29
UCS	Kinase	MRPL23	MAP3K11	0.814906931	3.34E-30
UCS	Kinase	MRPL23	MAP2K2	0.842577267	4.83E-34
UCS	Kinase	MRPL23	PHKG2	0.889909368	1.01E-42
UCS	TF	MRPL23	ZNF691	0.801083399	1.61E-28
UCS	TF	MRPL23	PIN1	0.806075284	4.12E-29
UCS	TF	MRPL23	ZNF408	0.814155412	4.15E-30
UCS	TF	MRPL23	E4F1	0.814485644	3.77E-30
UCS	TF	MRPL23	USF1	0.832635888	1.39E-32
UCS	TF	MRPL23	ETV2	0.833789346	9.54E-33
UCS	TF	MRPL23	ZNF524	0.836198741	4.28E-33
UCS	TF	MRPL23	ZNF32	0.839287914	1.51E-33
UCS	TF	MRPL23	THYN1	0.840098162	1.14E-33
UCS	TF	MRPL23	ZBTB48	0.847655807	7.92E-35
UCS	TF	MRPL23	IRF3	0.848609116	5.60E-35
UCS	TF	MRPL23	REXO4	0.851323812	2.06E-35
UCS	TF	MRPL23	CXXC1	0.851882016	1.67E-35
UCS	TF	MRPL23	ZGPAT	0.85261089	1.27E-35
UCS	TF	MRPL23	ZNF581	0.852795028	1.19E-35
UCS	TF	MRPL23	GLI4	0.855041443	5.06E-36
UCS	TF	MRPL23	THAP7	0.861953807	3.34E-37
UCS	TF	MRPL23	ZNF444	0.863937727	1.49E-37
UCS	TF	MRPL23	AKAP8L	0.864905	1.00E-37
UCS	TF	MRPL23	ZNF511	0.864918661	9.97E-38
UCS	TF	MRPL23	DRAP1	0.868121478	2.61E-38
UCS	TF	MRPL23	RBCK1	0.87100055	7.59E-39
UCS	TF	MRPL23	ZNF668	0.871803674	5.35E-39
UCS	TF	MRPL23	THAP3	0.88332524	2.68E-41
UCS	TF	MRPL23	ZNF688	0.894350137	9.75E-44
UCS	TF	MRPL23	ZNF428	0.898829995	8.30E-45
UCS	TF	MRPL23	MBD3	0.906257971	1.07E-46
UCS	TF	MRPL23	ZNF787	0.915670486	2.49E-49
UCS	TSG	MRPL23	NME1	0.800891207	1.70E-28
UCS	TSG	MRPL23	TUSC2	0.804456573	6.45E-29
UCS	TSG	MRPL23	PHB	0.804696127	6.04E-29
UCS	TSG	MRPL23	PIN1	0.806075284	4.12E-29
UCS	TSG	MRPL23	MAD1L1	0.80953667	1.56E-29
UCS	TSG	MRPL23	STUB1	0.811792599	8.22E-30
UCS	TSG	MRPL23	PFN1	0.825269838	1.46E-31
UCS	TSG	MRPL23	HTRA2	0.829465094	3.88E-32
UCS	TSG	MRPL23	PARK7	0.837524598	2.74E-33
UCS	TSG	MRPL23	AIP	0.839405368	1.45E-33
UCS	TSG	MRPL23	SIRT3	0.8396432	1.33E-33
UCS	TSG	MRPL23	GABARAP	0.840645736	9.45E-34
UCS	TSG	MRPL23	ZBTB48	0.847655807	7.92E-35
UCS	TSG	MRPL23	IRF3	0.848609116	5.60E-35
UCS	TSG	MRPL23	PYCARD	0.852053809	1.57E-35
UCS	TSG	MRPL23	GLTSCR2	0.865578723	7.58E-38
UCS	TSG	MRPL23	ZNF668	0.871803674	5.35E-39
UCS	TSG	MRPL23	GNB2L1	0.872268545	4.36E-39
UCS	TSG	MRPL23	NPRL2	0.906261011	1.07E-46
UCS	TSG	MRPL23	GADD45GIP1	0.933096004	3.92E-55
UCS	TSG	MRPL23	TSSC4	0.937726191	6.09E-57
UCS	TSG	MRPL23	SIRT6	0.9439002	1.39E-59
UCS	TSG	MRPL23	BRMS1	0.946074062	1.39E-60
UVM	Cell metabolism gene	MRPL23	POLR2E	0.808207215	1.28E-19
UVM	Cell metabolism gene	MRPL23	MTX1	0.809809727	9.54E-20
UVM	Cell metabolism gene	MRPL23	POLR2J	0.811511561	6.95E-20
UVM	Cell metabolism gene	MRPL23	TIMM13	0.814031092	4.33E-20
UVM	Cell metabolism gene	MRPL23	PGLS	0.826015995	4.11E-21
UVM	Cell metabolism gene	MRPL23	POLR2I	0.859139385	2.11E-24
UVM	CGC	MRPL23	TFPT	0.832132827	1.15E-21
UVM	Epifactor	MRPL23	TAF10	0.81892446	1.69E-20
UVM	Epifactor	MRPL23	BRMS1	0.82443528	5.66E-21
UVM	Epifactor	MRPL23	TFPT	0.832132827	1.15E-21
UVM	Epifactor	MRPL23	INO80E	0.840665136	1.79E-22
UVM	Epifactor	MRPL23	RUVBL2	0.872301716	5.97E-26
UVM	IUPHAR	MRPL23	DPP7	0.885155072	1.23E-27
UVM	TF	MRPL23	ZNF428	0.809582761	9.94E-20
UVM	TF	MRPL23	ZNF358	0.812669899	5.60E-20
UVM	TF	MRPL23	ZNF511	0.829331659	2.07E-21
UVM	TSG	MRPL23	BRMS1	0.82443528	5.66E-21
UVM	TSG	MRPL23	TSSC4	0.839178743	2.49E-22
UVM	TSG	MRPL23	GADD45GIP1	0.870409434	1.02E-25

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
STAD	MRPL23	MRPL15	-2.15546608137429	0.000334546435624361
LIHC	MRPL23	MRPL13	1.54402472107614	0.000655351190157038
COAD	MRPL23	MRPL41	-2.99561502382389	0.00144392251968384
KIRP	MRPL23	MRPL19	-1.9689242575519	0.00179363833740354
ESCA	MRPL23	MRPL47	-2.26373711796715	0.001953125
STAD	MRPL23	MRPS16	-1.64208084987431	0.00239070039242506
CHOL	MRPL23	MRPL3	-2.68429255990621	0.00390625
CHOL	MRPL23	MRPL41	-4.96379377542225	0.00390625
ESCA	MRPL23	MRPL3	-4.97897094908275	0.0048828125
THCA	MRPL23	MRPL41	-3.88188543554269	0.00492925389458784
PRAD	MRPL23	MRPS9	1.04379115553269	0.00496210155254694
COAD	MRPL23	MRPL15	1.17181689924568	0.00513318181037904
HNSC	MRPL23	MRPS16	-2.01564621821803	0.00518989327406416
KICH	MRPL23	MRPL19	-2.18550705564541	0.00672554969787598
ESCA	MRPL23	MRPL13	-1.07746088474995	0.0068359375
COAD	MRPL23	MRPL47	-2.29582381838246	0.00863465666770936
ESCA	MRPL23	MRPL17	-1.18756178214998	0.009765625
STAD	MRPL23	MRPL47	-1.4008685687155	0.0118026207201183
LIHC	MRPL23	MRPL17	-1.06225729770915	0.0124123499319886
STAD	MRPL23	MRPL4	1.4393539135682	0.0279771662317216
CHOL	MRPL23	MRPL19	-2.09295650388558	0.0390625
LIHC	MRPL23	MRPL47	-6.59586850948538	0.0416658979324166
KIRC	MRPL23	MRPL47	1.74758475364701	1.00533732476669e-06
KICH	MRPL23	MRPL15	1.54522142310359	1.19209289550781e-07
STAD	MRPL23	MRPL17	-3.90880705449186	1.49570405483246e-06
LUSC	MRPL23	MRPS9	-3.60637641031661	1.82498668910368e-07
LUSC	MRPL23	MRPL15	-4.43702988385305	1.91594862886626e-08
KIRC	MRPL23	MRPL3	1.69955762234244	1.97132191719422e-08
LUAD	MRPL23	MRPS9	-1.32894454884901	1.98978698949574e-05
COAD	MRPL23	MRPL4	2.77705897514473	2.98023223876954e-07
PRAD	MRPL23	MRPL41	1.31179686307216	4.41809300064344e-05
BRCA	MRPL23	MRPL15	-3.82448964360727	5.49451113259074e-14
LUSC	MRPL23	MRPL17	-6.83409683292749	6.93230040561614e-07
KICH	MRPL23	MRPL41	1.05103651319563	7.49826431274414e-05
LUAD	MRPL23	MRPL47	-1.74990909879567	9.53955602455483e-07

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MRPL23

USP44, ICT1, TCF3, SPP1, MRPL3, MRPL55, MRPL13, MRPL42, MRPL52, MRPS14, MRPL12, MRPL2, MRPL41, MRPS9, MRPL10, MRPL9, MRPL51, MRPS10, MRPL4, MRPL28, MPV17, TUFM, NENF, CDH2, ILF3, ABCC2, TXN2, ILF2, RPL8, RPS3, PPT2, HNRNPR, MTHFD1, RPS20, HNRNPU, RPL23, PRKCDBP, DLD, RPS15, RPS3A, OXA1L, SSBP1, HNRNPK, HNRNPM, RPS2, NDUFAB1, ASB10, PNMA1, FBXW11, RPS8, MRPL39, MRPS30, MRPL47, JAK3, MRPL50, Cd2ap, Ccser2, CHCHD10, COQ4, PDHA1, RIPK4, EFTUD2, ESR2, MEPCE, LARP7, DPF2, RECQL4, SERBP1, MRM1, TRMT61B, AURKAIP1, KIAA1429, RC3H1, RC3H2, SNRNP70, NFX1, KRTAP1-1, CYSRT1, KRTAP3-3, PLEKHA4, ZC3H18, PRKCI, PXN, EMC1, HNRNPC, HTRA2, NEK4, KIF23, ACAD9, AUH, C12orf65, C17orf80, C1QBP, C21orf33, C6orf203, C8orf82, CHCHD1, CS, GFM1, GRSF1, HINT2, LRPPRC, MDH2, METTL15, METTL17, MRPL11, MRPS12, MRPS26, MRRF, MTERF3, MTG1, MTG2, MTIF2, MTIF3, MTRF1, MTRF1L, NGRN, PMPCA, PMPCB, RPUSD4, TACO1, TBRG4, TEFM, TFAM, TMEM70, TRUB2, TSFM, VWA8, EXD2, BCAR1, NR3C1, DNAJA3, DNAJC15, HSCB, SMYD3, MRPL24, MRPL44, ATXN7L1, WDR5, MRPL30, NDUFAF5, MALSU1, HARS2, RBMS2, MRPS18A, MRPL32, RPL19, MRPL53, GADD45GIP1, NARS2, MRPL19, MRPL22, ARFGEF1, ARFGEF2, MRPL18, MRPL35, MRPL27, YBX2, RPL37, RPL13, PNPT1, LONP1, MRPL1, MRPL38, MRPL40, MRPL20, YBX1, TOP3A, GTPBP6, MRPL33, MRPS25, ABT1, ZNF574, BCKDHA, MCCC1, MRPL48, H1FNT, FECH, MRPL45, MRPL21, MRPL17, MRPL57, MRPL15, MRPL43, CPS1, ALDH5A1, RPL23A, MRPL37, MRPL49, RPS6, RPL10, CBWD1, MRPL16, ACSF2, MRPL46, RPL17, NEIL1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
MRPL23	chr11	1973349	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL23	chr11	2022992	TTTAGCATCTCAAGCTCCTAAA	T	Deletion	not_provided	Beckwith-Wiedemann_syndrome
MRPL23	chr11	2023045	G	A	single_nucleotide_variant	not_provided	Beckwith-Wiedemann_syndrome

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MRPL23	PAAD	chr11	1974067	1974067	G	T	Missense_Mutation	p.K93N	3
MRPL23	BLCA	chr11	1977518	1977518	G	A	Silent	p.L110L	3
MRPL23	BRCA	chr11	1977619	1977619	G	A	Missense_Mutation	p.R144Q	3
MRPL23	HNSC	chr11	1973401	1973401	A	G	Missense_Mutation	p.N62S	3
MRPL23	UCEC	chr11	1977578	1977578	C	T	Silent	p.L130	2
MRPL23	STAD	chr11	1973402	1973402	C	T	Silent		2
MRPL23	LIHC	chr11	1972132	1972132	C	-	Frame_Shift_Del	p.Y7fs	2
MRPL23	STAD	chr11	1973402	1973402	C	T	Silent	p.N62N	2
MRPL23	SKCM	chr11	1977612	1977612	C	T	Missense_Mutation	p.P142S	2
MRPL23	BRCA	chr11	1977552	1977552	G	A	Missense_Mutation	p.A122T	2
MRPL23	SKCM	chr11	1977613	1977613	C	T	Missense_Mutation	p.P142L	2
MRPL23	SKCM	chr11	1972219	1972219	C	T	Silent	p.P36P	2
MRPL23	UCEC	chr11	1973408	1973408	C	T	Silent	p.R59C	2
MRPL23	BLCA	chr11	1973375	1973375	C	T	Silent		1
MRPL23	PAAD	chr11	1974067	1974067	G	T	Missense_Mutation		1
MRPL23	DLBC	chr11	1972229	1972229	G	A	Missense_Mutation	p.V40M	1
MRPL23	SKCM	chr11	1973389	1973389	A	G	Missense_Mutation	p.E58G	1
MRPL23	KIRP	chr11	1972132	1972133	CC	-	Frame_Shift_Del	p.7_7del	1
MRPL23	BLCA	chr11	1977518	1977518	G	A	Silent		1
MRPL23	GBM	chr11	1973439	1973439	G	C	Missense_Mutation	p.G75_splice	1
MRPL23	SKCM	chr11	1972180	1972180	C	G	Missense_Mutation	p.N23K	1
MRPL23	LIHC	chr11	1993849	1993849	A	G	Missense_Mutation		1
MRPL23	BLCA	chr11	1972204	1972204	C	T	Silent		1
MRPL23	PRAD	chr11	1973409	1973409	G	A	Missense_Mutation	p.V65M	1
MRPL23	GBM	chr11	1973439	1973439	G	C	Missense_Mutation		1
MRPL23	SKCM	chr11	1977616	1977616	G	T	Missense_Mutation	p.R143L	1
MRPL23	LIHC	chr11	1972143	1972143	G	A	Missense_Mutation		1
MRPL23	BLCA	chr11	1973375	1973375	C	T	Silent	p.L53L	1
MRPL23	PRAD	chr11	1972238	1972238	C	T	Missense_Mutation	p.R43W	1
MRPL23	GBM	chr11	1972163	1972163	C	T	Missense_Mutation		1
MRPL23	SKCM	chr11	1977578	1977578	C	T	Silent	p.L130L	1
MRPL23	LIHC	chr11	1993874	1993874	G	-	Frame_Shift_Del	p.W128fs	1
MRPL23	SARC	chr11	1977607	1977607	G	T	Missense_Mutation		1
MRPL23	GBM	chr11	1973356	1973356	G	T	Splice_Site		1
MRPL23	BLCA	chr11	1972204	1972204	C	T	Silent	p.P31P	1
MRPL23	SARC	chr11	1973413	1973413	C	T	Missense_Mutation		1
MRPL23	HNSC	chr11	1973401	1973401	A	G	Missense_Mutation		1
MRPL23	LIHC	chr11	1983524	1983524	C	-	Frame_Shift_Del	p.T118fs	1
MRPL23	HNSC	chr11	1977552	1977552	G	A	Missense_Mutation		1
MRPL23	THCA	chr11	1977593	1977593	G	A	Silent	p.Q135Q	1
MRPL23	LUAD	chr11	1972198	1972198	G	T	Silent	p.V29V	1
MRPL23	HNSC	chr11	1977618	1977618	C	T	Missense_Mutation	p.R144W	1
MRPL23	THYM	chr11	1983560	1983560	G	T	Missense_Mutation		1
MRPL23	LUAD	chr11	1974042	1974042	T	C	Missense_Mutation	p.V85A	1
MRPL23	CESC	chr11	1983555	1983555	G	A	Silent		1
MRPL23	SKCM	chr11	1972217	1972217	C	T	Missense_Mutation	p.P36S	1
MRPL23	HNSC	chr11	1977596	1977596	G	C	Missense_Mutation	p.Q136H	1
MRPL23	THYM	chr11	1973398	1973398	A	G	Missense_Mutation		1
MRPL23	LUSC	chr11	1977643	1977643	G	T	Missense_Mutation	p.G152V	1
MRPL23	COAD	chr11	1972143	1972143	G	A	Missense_Mutation	p.R11Q	1
MRPL23	THYM	chr11	1993827	1993827	C	T	Silent		1
MRPL23	OV	chr11	1972164	1972164	G	C	Missense_Mutation	p.R18P	1
MRPL23	COAD	chr11	1972205	1972205	G	A	Missense_Mutation	p.G32S	1
MRPL23	SKCM	chr11	1973428	1973428	G	A	Missense_Mutation	p.R71Q	1
MRPL23	HNSC	chr11	1968600	1968600	G	-	Frame_Shift_Del	p.R3fs	1

Copy number variation (CNV) of MRPL23
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MRPL23
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
75946	N/A	BI053738	BLOC1S5-TXNDC5	chr6	7882050	-	MRPL23	chr11	2018805	+
75946	ACC	TCGA-OR-A5J1	CIAPIN1	chr16	57481253	-	MRPL23	chr11	1972128	+
75946	N/A	BG005486	FBLN1	chr22	45944585	-	MRPL23	chr11	2016807	+
75946	N/A	AI377593	GNAI2	chr3	50296586	-	MRPL23	chr11	2018056	+
75946	N/A	AW938763	H19	chr11	2018510	-	MRPL23	chr11	2016466	+
75946	N/A	BF997148	H19	chr11	2016802	-	MRPL23	chr11	2016762	+
95128	N/A	DA572152	MRPL23	chr11	2016829	+	BRD9	chr5	891824	-
95399	N/A	CB164280	MRPL23	chr11	2017591	+	H19	chr11	2016921	-
100804	N/A	AF116709	MRPL23	chr11	2016793	+	KDM4C	chr9	6827216	+
102949	N/A	BC004532	MRPL23	chr11	2018165	+	MAP3K13	chr3	185136444	-
81721	N/A	AA738002	MRPL23	chr11	2016466	+	MLLT11	chr1	151040070	-
75946	N/A	BE146050	MRPL23	chr11	2019002	+	MRPL23	chr11	2016941	+
102052	N/A	AF074689	MRPL23	chr11	2018981	+	NCEH1	chr3	172361111	+
103109	N/A	BC010054	MRPL23	chr11	2018080	+	RPSAP58	chr19	24009905	+
100586	Non-Cancer	189N	MRPL23	chr11	1974085	+	SKIL	chr3	170077486	+
100428	N/A	BG008301	MRPL23	chr11	2018315	+	TCEA3	chr1	23743875	-
95319	N/A	BU596366	MRPL23	chr11	1972186	+	UBB	chr17	16284717	+
102395	N/A	AF118081	MRPL23	chr11	2019034	+	WDR62	chr19	36561143	+
54976	N/A	AI089195	MRPL23	chr11	2016467	+	ZNF174	chr16	3452055	-
75963	N/A	AA912468	RPL14	chr3	40503696	-	MRPL23	chr11	2018434	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRP	MRPL23	0.000292763253418458	0.0082
MESO	MRPL23	0.00446721425242642	0.12
PAAD	MRPL23	0.0239727616270958	0.62
THCA	MRPL23	0.0349910911787002	0.87

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KICH	MRPL23	0.0176718744528457	0.57
LGG	MRPL23	5.44507637800258e-05	0.0018
BRCA	MRPL23	0.0408754206359244	1
THYM	MRPL23	0.044008695129055	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source