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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL36AL (NCBI Gene ID:6166)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL36AL
	Gene ID: 6166
	Gene Symbol	RPL36AL
	Gene ID	6166
	Gene Name	ribosomal protein L36a like
	Synonyms	RPL36A
	Cytomap	14q21.3
	Type of Gene	protein-coding
	Description	60S ribosomal protein L36a-likelarge ribosomal subunit protein eL42-likeribosomal protein HL44
	Modification date	20200313
	UniProtAcc	Q969Q0

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPL36AL	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPL36AL[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL36AL	The CCA-end of P-tRNA Contacts Both the Human RPL36AL and the A-site Bound Translation Termination Factor eRF1 at the Peptidyl Transferase Center of the Human 80S Ribosome	25191528

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KIRC	RPL36AL	-6.25347183174259	0.000902380264885279
BLCA	RPL36AL	-2.15718404153454	0.00391769409179688
LIHC	RPL36AL	-1.01636355951308	0.00667634152888414
COAD	RPL36AL	-4.57155487583486	0.00938254594802858
ESCA	RPL36AL	1.49722244666217	0.0322265625
UCEC	RPL36AL	-1.24834751809083	0.046875

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LGG	RPL36AL	0.091884279	0.020303779
ESCA	RPL36AL	-0.04347671	0.04321187

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL36AL (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	RPL36AL	B3GAT3	0.804213657	5.80E-12
DLBC	Cell metabolism gene	RPL36AL	PSMB4	0.8080678	3.84E-12
DLBC	Cell metabolism gene	RPL36AL	PSMD13	0.809650144	3.23E-12
DLBC	Cell metabolism gene	RPL36AL	MED27	0.811252142	2.71E-12
DLBC	Cell metabolism gene	RPL36AL	PSMC1	0.811425466	2.66E-12
DLBC	Cell metabolism gene	RPL36AL	PHPT1	0.812634588	2.33E-12
DLBC	Cell metabolism gene	RPL36AL	ACOT8	0.814998368	1.79E-12
DLBC	Cell metabolism gene	RPL36AL	TOMM7	0.81681702	1.45E-12
DLBC	Cell metabolism gene	RPL36AL	POLR2I	0.818370131	1.22E-12
DLBC	Cell metabolism gene	RPL36AL	SAT2	0.818699177	1.17E-12
DLBC	Cell metabolism gene	RPL36AL	PSMC5	0.827240404	4.26E-13
DLBC	Cell metabolism gene	RPL36AL	TIMM9	0.830225551	2.95E-13
DLBC	Cell metabolism gene	RPL36AL	PSMD4	0.836759383	1.29E-13
DLBC	Cell metabolism gene	RPL36AL	PSMB3	0.839081626	9.52E-14
DLBC	Cell metabolism gene	RPL36AL	DPM2	0.839101947	9.49E-14
DLBC	Cell metabolism gene	RPL36AL	PHKG2	0.857316034	7.36E-15
DLBC	Cell metabolism gene	RPL36AL	POLE4	0.865691225	2.01E-15
DLBC	Cell metabolism gene	RPL36AL	DGUOK	0.869040654	1.17E-15
DLBC	Cell metabolism gene	RPL36AL	FAU	0.874790162	4.44E-16
DLBC	Cell metabolism gene	RPL36AL	PFDN5	0.896518092	7.05E-18
DLBC	CGC	RPL36AL	TFPT	0.814524804	1.88E-12
DLBC	CGC	RPL36AL	SDHAF2	0.844053842	4.89E-14
DLBC	Epifactor	RPL36AL	TFPT	0.814524804	1.88E-12
DLBC	Epifactor	RPL36AL	BRMS1	0.848551852	2.63E-14
DLBC	Epifactor	RPL36AL	ZNHIT1	0.862533855	3.31E-15
DLBC	Epifactor	RPL36AL	TAF10	0.86639163	1.80E-15
DLBC	IUPHAR	RPL36AL	PHKG2	0.857316034	7.36E-15
DLBC	Kinase	RPL36AL	PHKG2	0.857316034	7.36E-15
DLBC	TF	RPL36AL	THAP7	0.823950926	6.32E-13
DLBC	TF	RPL36AL	THAP3	0.824976304	5.59E-13
DLBC	TSG	RPL36AL	BRMS1	0.848551852	2.63E-14
DLBC	TSG	RPL36AL	GADD45GIP1	0.85241454	1.51E-14
DLBC	TSG	RPL36AL	TSSC4	0.8555816	9.53E-15
MESO	Cell metabolism gene	RPL36AL	TIMM9	0.814287075	8.78E-22
PRAD	Cell metabolism gene	RPL36AL	PFDN5	0.800942675	3.59E-124
THYM	Cell metabolism gene	RPL36AL	GFER	0.802309367	1.16E-28
THYM	Cell metabolism gene	RPL36AL	SEC61G	0.803699017	7.94E-29
THYM	Cell metabolism gene	RPL36AL	IDH3G	0.804959823	5.61E-29
THYM	Cell metabolism gene	RPL36AL	SNRPD3	0.806054341	4.15E-29
THYM	Cell metabolism gene	RPL36AL	POLR2H	0.80687688	3.30E-29
THYM	Cell metabolism gene	RPL36AL	TIMM50	0.815786795	2.58E-30
THYM	Cell metabolism gene	RPL36AL	TIMM13	0.816640541	2.00E-30
THYM	Cell metabolism gene	RPL36AL	GUK1	0.820865578	5.66E-31
THYM	Cell metabolism gene	RPL36AL	ACOT8	0.821129472	5.23E-31
THYM	Cell metabolism gene	RPL36AL	TIMM8B	0.824392546	1.92E-31
THYM	Cell metabolism gene	RPL36AL	PSMC1	0.825896752	1.20E-31
THYM	Cell metabolism gene	RPL36AL	TIMM9	0.828937151	4.60E-32
THYM	Cell metabolism gene	RPL36AL	PSMB7	0.831852491	1.80E-32
THYM	Cell metabolism gene	RPL36AL	DPM2	0.833728367	9.73E-33
THYM	Cell metabolism gene	RPL36AL	PSMB3	0.834138206	8.50E-33
THYM	Cell metabolism gene	RPL36AL	TOMM7	0.83564586	5.15E-33
THYM	Cell metabolism gene	RPL36AL	SLC27A5	0.838665703	1.86E-33
THYM	Cell metabolism gene	RPL36AL	PSMB1	0.840267879	1.08E-33
THYM	Cell metabolism gene	RPL36AL	APRT	0.840351558	1.05E-33
THYM	Cell metabolism gene	RPL36AL	SSR2	0.843394816	3.63E-34
THYM	Cell metabolism gene	RPL36AL	DPM3	0.844078463	2.85E-34
THYM	Cell metabolism gene	RPL36AL	POLR2I	0.848022627	6.93E-35
THYM	Cell metabolism gene	RPL36AL	POLR2J	0.857137723	2.25E-36
THYM	Cell metabolism gene	RPL36AL	SNRPD2	0.861578468	3.89E-37
THYM	Cell metabolism gene	RPL36AL	PGLS	0.864465771	1.20E-37
THYM	Cell metabolism gene	RPL36AL	POLR2F	0.865563725	7.63E-38
THYM	Cell metabolism gene	RPL36AL	FAU	0.887484745	3.45E-42
THYM	Cell metabolism gene	RPL36AL	PFDN5	0.896269923	3.44E-44
THYM	CGC	RPL36AL	TFPT	0.835767152	4.95E-33
THYM	Epifactor	RPL36AL	INO80E	0.806554563	3.61E-29
THYM	Epifactor	RPL36AL	FBL	0.816491072	2.09E-30
THYM	Epifactor	RPL36AL	C17orf49	0.825656945	1.30E-31
THYM	Epifactor	RPL36AL	PRPF31	0.826754635	9.18E-32
THYM	Epifactor	RPL36AL	BRMS1	0.832308272	1.55E-32
THYM	Epifactor	RPL36AL	TFPT	0.835767152	4.95E-33
THYM	Epifactor	RPL36AL	SIRT6	0.837099508	3.17E-33
THYM	Epifactor	RPL36AL	ZNHIT1	0.860809152	5.30E-37
THYM	Epifactor	RPL36AL	TAF10	0.860847549	5.22E-37
THYM	Epifactor	RPL36AL	CCDC101	0.861797317	3.56E-37
THYM	IUPHAR	RPL36AL	MMP24	0.810972823	1.04E-29
THYM	IUPHAR	RPL36AL	SIRT3	0.813318455	5.30E-30
THYM	IUPHAR	RPL36AL	SIRT6	0.837099508	3.17E-33
THYM	IUPHAR	RPL36AL	SLC27A5	0.838665703	1.86E-33
THYM	IUPHAR	RPL36AL	PSMB1	0.840267879	1.08E-33
THYM	TF	RPL36AL	ZNF428	0.810000987	1.37E-29
THYM	TF	RPL36AL	THAP7	0.810328616	1.25E-29
THYM	TF	RPL36AL	ZNF32	0.821666001	4.44E-31
THYM	TF	RPL36AL	THAP3	0.821681433	4.42E-31
THYM	TF	RPL36AL	DRAP1	0.822061029	3.93E-31
THYM	TF	RPL36AL	ZNF524	0.850884017	2.42E-35
THYM	TSG	RPL36AL	GLTSCR2	0.813261341	5.38E-30
THYM	TSG	RPL36AL	SIRT3	0.813318455	5.30E-30
THYM	TSG	RPL36AL	TSSC4	0.820118883	7.10E-31
THYM	TSG	RPL36AL	BRMS1	0.832308272	1.55E-32
THYM	TSG	RPL36AL	SIRT6	0.837099508	3.17E-33
THYM	TSG	RPL36AL	NPRL2	0.841287906	7.57E-34
THYM	TSG	RPL36AL	GNB2L1	0.843405456	3.61E-34
THYM	TSG	RPL36AL	GABARAP	0.849919253	3.46E-35
THYM	TSG	RPL36AL	GADD45GIP1	0.862694935	2.48E-37
UCS	Cell metabolism gene	RPL36AL	GFER	0.802309367	1.16E-28
UCS	Cell metabolism gene	RPL36AL	SEC61G	0.803699017	7.94E-29
UCS	Cell metabolism gene	RPL36AL	IDH3G	0.804959823	5.61E-29
UCS	Cell metabolism gene	RPL36AL	SNRPD3	0.806054341	4.15E-29
UCS	Cell metabolism gene	RPL36AL	POLR2H	0.80687688	3.30E-29
UCS	Cell metabolism gene	RPL36AL	TIMM50	0.815786795	2.58E-30
UCS	Cell metabolism gene	RPL36AL	TIMM13	0.816640541	2.00E-30
UCS	Cell metabolism gene	RPL36AL	GUK1	0.820865578	5.66E-31
UCS	Cell metabolism gene	RPL36AL	ACOT8	0.821129472	5.23E-31
UCS	Cell metabolism gene	RPL36AL	TIMM8B	0.824392546	1.92E-31
UCS	Cell metabolism gene	RPL36AL	PSMC1	0.825896752	1.20E-31
UCS	Cell metabolism gene	RPL36AL	TIMM9	0.828937151	4.60E-32
UCS	Cell metabolism gene	RPL36AL	PSMB7	0.831852491	1.80E-32
UCS	Cell metabolism gene	RPL36AL	DPM2	0.833728367	9.73E-33
UCS	Cell metabolism gene	RPL36AL	PSMB3	0.834138206	8.50E-33
UCS	Cell metabolism gene	RPL36AL	TOMM7	0.83564586	5.15E-33
UCS	Cell metabolism gene	RPL36AL	SLC27A5	0.838665703	1.86E-33
UCS	Cell metabolism gene	RPL36AL	PSMB1	0.840267879	1.08E-33
UCS	Cell metabolism gene	RPL36AL	APRT	0.840351558	1.05E-33
UCS	Cell metabolism gene	RPL36AL	SSR2	0.843394816	3.63E-34
UCS	Cell metabolism gene	RPL36AL	DPM3	0.844078463	2.85E-34
UCS	Cell metabolism gene	RPL36AL	POLR2I	0.848022627	6.93E-35
UCS	Cell metabolism gene	RPL36AL	POLR2J	0.857137723	2.25E-36
UCS	Cell metabolism gene	RPL36AL	SNRPD2	0.861578468	3.89E-37
UCS	Cell metabolism gene	RPL36AL	PGLS	0.864465771	1.20E-37
UCS	Cell metabolism gene	RPL36AL	POLR2F	0.865563725	7.63E-38
UCS	Cell metabolism gene	RPL36AL	FAU	0.887484745	3.45E-42
UCS	Cell metabolism gene	RPL36AL	PFDN5	0.896269923	3.44E-44
UCS	CGC	RPL36AL	TFPT	0.835767152	4.95E-33
UCS	Epifactor	RPL36AL	INO80E	0.806554563	3.61E-29
UCS	Epifactor	RPL36AL	FBL	0.816491072	2.09E-30
UCS	Epifactor	RPL36AL	C17orf49	0.825656945	1.30E-31
UCS	Epifactor	RPL36AL	PRPF31	0.826754635	9.18E-32
UCS	Epifactor	RPL36AL	BRMS1	0.832308272	1.55E-32
UCS	Epifactor	RPL36AL	TFPT	0.835767152	4.95E-33
UCS	Epifactor	RPL36AL	SIRT6	0.837099508	3.17E-33
UCS	Epifactor	RPL36AL	ZNHIT1	0.860809152	5.30E-37
UCS	Epifactor	RPL36AL	TAF10	0.860847549	5.22E-37
UCS	Epifactor	RPL36AL	CCDC101	0.861797317	3.56E-37
UCS	IUPHAR	RPL36AL	MMP24	0.810972823	1.04E-29
UCS	IUPHAR	RPL36AL	SIRT3	0.813318455	5.30E-30
UCS	IUPHAR	RPL36AL	SIRT6	0.837099508	3.17E-33
UCS	IUPHAR	RPL36AL	SLC27A5	0.838665703	1.86E-33
UCS	IUPHAR	RPL36AL	PSMB1	0.840267879	1.08E-33
UCS	TF	RPL36AL	ZNF428	0.810000987	1.37E-29
UCS	TF	RPL36AL	THAP7	0.810328616	1.25E-29
UCS	TF	RPL36AL	ZNF32	0.821666001	4.44E-31
UCS	TF	RPL36AL	THAP3	0.821681433	4.42E-31
UCS	TF	RPL36AL	DRAP1	0.822061029	3.93E-31
UCS	TF	RPL36AL	ZNF524	0.850884017	2.42E-35
UCS	TSG	RPL36AL	GLTSCR2	0.813261341	5.38E-30
UCS	TSG	RPL36AL	SIRT3	0.813318455	5.30E-30
UCS	TSG	RPL36AL	TSSC4	0.820118883	7.10E-31
UCS	TSG	RPL36AL	BRMS1	0.832308272	1.55E-32
UCS	TSG	RPL36AL	SIRT6	0.837099508	3.17E-33
UCS	TSG	RPL36AL	NPRL2	0.841287906	7.57E-34
UCS	TSG	RPL36AL	GNB2L1	0.843405456	3.61E-34
UCS	TSG	RPL36AL	GABARAP	0.849919253	3.46E-35
UCS	TSG	RPL36AL	GADD45GIP1	0.862694935	2.48E-37

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
BLCA	RPL36AL	RPL10A	-6.44657805140652	0.000164031982421875
KICH	RPL36AL	RPS17	-9.74128123960814	0.000556409358978271
PRAD	RPL36AL	RPL12	1.03140367520778	0.0008447947014615
PRAD	RPL36AL	RPS15	2.38682220239643	0.000931746432967977
KIRP	RPL36AL	RPS11	-1.01861570565103	0.00105937570333481
KICH	RPL36AL	RPL19	1.36901182894089	0.00250792503356934
HNSC	RPL36AL	RPS17	-1.41932406270792	0.00608886057921154
LUSC	RPL36AL	RPS15	-1.54018132537089	0.00665527288479679
LUAD	RPL36AL	RPL19	-1.31398026615725	0.00993159558412698
BLCA	RPL36AL	RPL12	-3.6124920986454	0.012359619140625
KICH	RPL36AL	RPL10A	1.57107790372051	0.0124664902687073
HNSC	RPL36AL	RPL12	1.31949815918867	0.0149245594448075
THCA	RPL36AL	FAU	1.18509450470262	0.0152379297688856
KIRP	RPL36AL	FAU	-1.04355048353271	0.0309218638576567
COAD	RPL36AL	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPL36AL	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPL36AL	RPS17	-1.14106059335771	1.12651178935203e-06
KIRP	RPL36AL	RPL12	-2.07599071662134	1.26352533698082e-05
KIRC	RPL36AL	FAU	-2.50135425883801	1.33253564327251e-08
KIRC	RPL36AL	RPL19	-2.73485271276676	1.33980982873695e-10
LUAD	RPL36AL	RPL30	-1.98579595284099	1.50488235365288e-05
KIRC	RPL36AL	RPL35A	-2.33246813425378	3.7449081319937e-09
BRCA	RPL36AL	RPL12	-2.15215406494599	4.57396841975666e-06
THCA	RPL36AL	RPL12	1.7343782363164	5.23308492993332e-06
KIRC	RPL36AL	RPL10A	-2.3455028090226	5.61779186490163e-09
KIRC	RPL36AL	RPL11	-5.47536848868151	6.13619476098216e-10
KIRC	RPL36AL	RPS15	-1.51134139657827	6.64395189280361e-09
KIRC	RPL36AL	RPL12	-2.90541430500864	8.74519390827313e-10
KIRP	RPL36AL	RPS15	-1.53644743209735	9.0546440333128e-05
LUSC	RPL36AL	RPL30	-2.27386662283158	9.09971457907932e-05
KIRC	RPL36AL	RPL30	-1.65763742142219	9.40007073737459e-12

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL36AL

GSK3B, C7orf25, TAF1D, ESR1, ESR2, UBL4A, KRTAP10-7, HIST1H1A, RPL10A, RPL14, ZNF22, DRICH1, DHX8, NPM1, ZC3H3, NAP1L1, MRPS30, RPL35A, RPL27A, RPL3, RPS15, RPS27, HSPB2, KIF11, CDH1, CDC14B, DUSP11, FAN1, PTP4A1, RBM34, HIST1H1T, E4F1, SET, ZNF71, ZNF490, RBM4, IKZF5, RPL37A, BHLHA15, RSBN1, RPS7, RPS14, ZBTB48, PDGFB, CDX1, RPL7, MDK, CLEC3A, CCDC59, MRPL10, PTPN6, RNGTT, TRIM25, LNX1, GSK3A, PYHIN1, RIOK1, HEXIM1, MEPCE, LARP7, AGR2, NRAS, RC3H1, RC3H2, NR2C2, SNRNP70, WWP2, OBSL1, PLEKHA4, HCVgp1, ZC3H18, SH3GL3, E, M, nsp13, nsp14, nsp4, nsp5, nsp6, ORF3a, ORF7a, S, ANLN, ECT2, KIF14, KIF20A, PRC1, MKI67, MAFB, NR3C1, CIAO1, NF2, SUV420H2, TRIM37, UFL1, DDRGK1, SKA3, ZBTB2, LLPH, LYAR, VPRBP, PDCD11, HNRNPCL1, RPL4, PRKRA, MRPL18, KRR1, ADARB1, H1FNT, SRSF5, RPS19, RPS3, HIST1H1B, ZBTB47, RPL11, RPL7A, RPL13A, NOP2, NOTCH2, FGF13, CCDC137, SRP14, DGKZ, YBX2, RPL26L1, MAGEB2, RPL19, RPL23A, SHCBP1, LRP1B, LTBP2, YBX1, KAL1, SDAD1, GNL3, RPS16, MRPL13, ILF3, RPL35, DDX21, EZH1, LIN28B, RPL26, RPL28, TNFRSF1B, RPSAP58, HIST1H2AM, TRIM41, UTP23, HIST1H1D, FGF17, LIN28A, THAP3, FGFBP1, RPS13, RPS10, SORL1, RPL31, SEMA3C, H2AFB2, ABT1, RBM28, RPL36, H2AFB3, GNL2, SRPK3, PURG, COL2A1, SETD6, RPF1, RPLP0, MPHOSPH10, NIFK, MRPL40, ZNF768, NUDT13, AATF, MRPL53, MRPL30, MRPL51, ZFP91, WDR53, RBM4B, LUC7L, ZC3H10, C1orf35, MRPS2, LTV1, ZNF574, HJURP, NDUFAF5, GADD45GIP1, LRRC1, MRPL3, RRP12, GLYR1, NOP10, RPS6, FTSJ1, REXO4, MRPS24, KRI1, MRPS34, RPS8, GAR1, RPS4Y2, SURF6, MRPS25, KNOP1, UTP3, PRR3, SNX7, H2AFZ, MRPS7, HIST1H1E, MAS1L, CTCF, MRPL16, RPL17, RPL15, DDX24, NPM3, MAK16, RPL27, PPM1G, DICER1, HIST1H2AE, MRPL52, FTL, RPL18A, C8orf33, MRPS5, MRPS9, MRPS11, LARP1B, KBTBD7, CBX6, POP1, ZC3HAV1, ZCRB1, CHERP, IPO7, PTCD3, STAU1, U2SURP, RPL8, MRPS10, UBE2O, IPO5, ZNF512, RPL30, NRD1, OR2A4, MAP7D1, MRPL28, LARP1, MDM2, MRPL35, MRPL46, RPL5, MRPS26, NAP1L4, OSBPL3, KBTBD6, APOBEC3D, SRSF12, RPS27A, MRPL24, DGCR8, NOL10, MRPS33, BTF3, PRPF6, Hnrnpf, Rbm14, Nufip2, NHLH1, KLF15, KLF3, KLF16, KLF8,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL36AL	ESCA	chr14	50085611	50085611	T	C	Missense_Mutation	p.E71G	2
RPL36AL	THCA	chr14	50085726	50085726	A	C	Missense_Mutation	p.L33V	2
RPL36AL	ESCA	chr14	50085611	50085611	T	C	Missense_Mutation		2
RPL36AL	UCEC	chr14	50085520	50085520	G	A	Silent	p.G101	2
RPL36AL	UCEC	chr14	50085653	50085653	C	T	Missense_Mutation	p.R57Q	2
RPL36AL	UVM	chr14	50085633	50085633	T	C	Missense_Mutation		2
RPL36AL	UVM	chr14	50085633	50085633	T	C	Missense_Mutation	p.K64E	2
RPL36AL	SKCM	chr14	50085510	50085510	G	T	Missense_Mutation	p.Q105K	1
RPL36AL	THCA	chr14	50085726	50085726	A	C	Missense_Mutation		1
RPL36AL	THCA	chr14	50085726	50085726	A	C	Missense_Mutation	p.Q33E	1
RPL36AL	THYM	chr14	50085586	50085586	G	T	Silent		1
RPL36AL	ESCA	chr14	50085611	50085611	T	C	Missense_Mutation	p.K71R	1
RPL36AL	THYM	chr14	50085586	50085586	G	T	Silent	p.K79K	1
RPL36AL	LIHC	chr14	50085753	50085753	T	C	Missense_Mutation		1
RPL36AL	LUAD	chr14	50085644	50085644	G	C	Missense_Mutation	p.A60G	1
RPL36AL	MESO	chr14	50085831	50085831	C	A	Missense_Mutation		1
RPL36AL	PRAD	chr14	50085776	50085776	C	T	Missense_Mutation	p.G16D	1
RPL36AL	UVM	chr14	50085633	50085633	T	C	Missense_Mutation	p.M64V	1
RPL36AL	SKCM	chr14	50085802	50085802	G	A	Silent	p.T7T	1

Copy number variation (CNV) of RPL36AL
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Fusion gene breakpoints (product of the structural variants (SVs)) across RPL36AL
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Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
97558	N/A	FN171668	AHCYL1	chr1	110564371	-	RPL36AL	chr14	50085436	-
97558	N/A	BI494273	RELL1	chr4	37632648	+	RPL36AL	chr14	50085406	+
76608	BLCA	TCGA-DK-A2I2-01A	RPL36AL	chr14	50087280	-	MAP4K5	chr14	50923312	-
96651	N/A	BI494274	RPL36AL	chr14	50085406	-	UGGT2	chr13	96631795	+
97558	UCEC	TCGA-AP-A5FX-01A	RPS29	chr14	50052668	-	RPL36AL	chr14	50085858	-
97559	N/A	BF878159	USP4	chr3	49321802	+	RPL36AL	chr14	50085758	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
BLCA	RPL36AL	0.00608662629032561	0.17
STAD	RPL36AL	0.0245962297187371	0.66

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	RPL36AL	0.0108239225394136	0.36
LUAD	RPL36AL	0.0110748275827441	0.36
CESC	RPL36AL	0.0407172397860567	1
PCPG	RPL36AL	0.0341586886066028	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source