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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL41 (NCBI Gene ID:6171)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL41
	Gene ID: 6171
	Gene Symbol	RPL41
	Gene ID	6171
	Gene Name	ribosomal protein L41
	Synonyms	L41
	Cytomap	12q13.2
	Type of Gene	protein-coding
	Description	60S ribosomal protein L41HG12 proteinhomologue of yeast ribosomal protein YL41large ribosomal subunit protein eL41
	Modification date	20200313
	UniProtAcc	P62945

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPL41	GO:0002181	cytoplasmic translation	25957688

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPL41[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL41	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000501597	56510558	56510583	5CDS-5UTR
ENST00000501597	56510972	56510995	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
STAD	RPL41	-2.14934386855632	0.000397900585085154

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
UCEC	RPL41	0.097803784	0.021697189
READ	RPL41	0.073667189	0.02232349
LIHC	RPL41	0.054086958	0.027937389

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL41 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	RPL41	PFDN5	0.870738017	7.67E-15
CHOL	CGC	RPL41	NACA	0.863712783	2.22E-14
CHOL	Epifactor	RPL41	FBL	0.803792667	2.98E-11
DLBC	Cell metabolism gene	RPL41	GFER	0.80789518	3.91E-12
DLBC	Cell metabolism gene	RPL41	TOMM22	0.81920764	1.10E-12
DLBC	Cell metabolism gene	RPL41	NME2	0.839102707	9.49E-14
DLBC	Cell metabolism gene	RPL41	FAU	0.857878552	6.76E-15
DLBC	Cell metabolism gene	RPL41	PFDN5	0.863404678	2.89E-15
DLBC	Cell metabolism gene	RPL41	SNRPD2	0.903192996	1.64E-18
DLBC	CGC	RPL41	NACA	0.919179048	3.08E-20
DLBC	Epifactor	RPL41	FBL	0.836590974	1.32E-13
DLBC	TF	RPL41	NME2	0.839102707	9.49E-14
DLBC	TSG	RPL41	HINT1	0.823882687	6.38E-13
DLBC	TSG	RPL41	GNB2L1	0.870211167	9.63E-16
GBM	Cell metabolism gene	RPL41	FAU	0.802883816	4.88E-40
GBM	Cell metabolism gene	RPL41	PSMA5	0.808180645	6.15E-41
GBM	Cell metabolism gene	RPL41	SNRPG	0.809440293	3.72E-41
GBM	Cell metabolism gene	RPL41	SNRPD2	0.822755551	1.45E-43
GBM	Cell metabolism gene	RPL41	PFDN5	0.876805146	6.07E-56
HNSC	Cell metabolism gene	RPL41	PFDN5	0.834433574	4.59E-148
LGG	Cell metabolism gene	RPL41	PFDN5	0.808485038	1.16E-123
LGG	Cell metabolism gene	RPL41	FAU	0.822441832	1.83E-131
OV	Cell metabolism gene	RPL41	PFDN5	0.808107423	2.59E-72
PAAD	CGC	RPL41	NACA	0.834204959	1.16E-48
THYM	Cell metabolism gene	RPL41	LCMT1	0.803131979	9.27E-29
THYM	Cell metabolism gene	RPL41	PSMC5	0.803609459	8.13E-29
THYM	Cell metabolism gene	RPL41	PTGES2	0.80480679	5.86E-29
THYM	Cell metabolism gene	RPL41	FAU	0.807623781	2.68E-29
THYM	Cell metabolism gene	RPL41	GMPPA	0.811233485	9.65E-30
THYM	Cell metabolism gene	RPL41	TIMM13	0.812997925	5.81E-30
THYM	Cell metabolism gene	RPL41	GSTP1	0.813626327	4.84E-30
THYM	Cell metabolism gene	RPL41	IMPDH2	0.814011034	4.33E-30
THYM	Cell metabolism gene	RPL41	TALDO1	0.814220965	4.07E-30
THYM	Cell metabolism gene	RPL41	SLC27A5	0.815369411	2.91E-30
THYM	Cell metabolism gene	RPL41	TOMM7	0.82498955	1.60E-31
THYM	Cell metabolism gene	RPL41	DPM2	0.825387384	1.41E-31
THYM	Cell metabolism gene	RPL41	EXOSC4	0.829363914	4.01E-32
THYM	Cell metabolism gene	RPL41	MMAB	0.836384245	4.03E-33
THYM	Cell metabolism gene	RPL41	SSR2	0.839890311	1.23E-33
THYM	Cell metabolism gene	RPL41	GFER	0.839911634	1.22E-33
THYM	Cell metabolism gene	RPL41	PFDN5	0.852325918	1.42E-35
THYM	Epifactor	RPL41	EXOSC4	0.829363914	4.01E-32
THYM	Epifactor	RPL41	FBL	0.867149421	3.93E-38
THYM	IUPHAR	RPL41	PTGES2	0.80480679	5.86E-29
THYM	IUPHAR	RPL41	IMPDH2	0.814011034	4.33E-30
THYM	IUPHAR	RPL41	SLC27A5	0.815369411	2.91E-30
THYM	TF	RPL41	REXO4	0.8438032	3.14E-34
THYM	TF	RPL41	ZNF581	0.863418239	1.85E-37
THYM	TSG	RPL41	STUB1	0.80731224	2.92E-29
THYM	TSG	RPL41	GSTP1	0.813626327	4.84E-30
THYM	TSG	RPL41	PHB	0.815250211	3.02E-30
THYM	TSG	RPL41	TSSC4	0.840246058	1.08E-33
UCS	Cell metabolism gene	RPL41	LCMT1	0.803131979	9.27E-29
UCS	Cell metabolism gene	RPL41	PSMC5	0.803609459	8.13E-29
UCS	Cell metabolism gene	RPL41	PTGES2	0.80480679	5.86E-29
UCS	Cell metabolism gene	RPL41	FAU	0.807623781	2.68E-29
UCS	Cell metabolism gene	RPL41	GMPPA	0.811233485	9.65E-30
UCS	Cell metabolism gene	RPL41	TIMM13	0.812997925	5.81E-30
UCS	Cell metabolism gene	RPL41	GSTP1	0.813626327	4.84E-30
UCS	Cell metabolism gene	RPL41	IMPDH2	0.814011034	4.33E-30
UCS	Cell metabolism gene	RPL41	TALDO1	0.814220965	4.07E-30
UCS	Cell metabolism gene	RPL41	SLC27A5	0.815369411	2.91E-30
UCS	Cell metabolism gene	RPL41	TOMM7	0.82498955	1.60E-31
UCS	Cell metabolism gene	RPL41	DPM2	0.825387384	1.41E-31
UCS	Cell metabolism gene	RPL41	EXOSC4	0.829363914	4.01E-32
UCS	Cell metabolism gene	RPL41	MMAB	0.836384245	4.03E-33
UCS	Cell metabolism gene	RPL41	SSR2	0.839890311	1.23E-33
UCS	Cell metabolism gene	RPL41	GFER	0.839911634	1.22E-33
UCS	Cell metabolism gene	RPL41	PFDN5	0.852325918	1.42E-35
UCS	Epifactor	RPL41	EXOSC4	0.829363914	4.01E-32
UCS	Epifactor	RPL41	FBL	0.867149421	3.93E-38
UCS	IUPHAR	RPL41	PTGES2	0.80480679	5.86E-29
UCS	IUPHAR	RPL41	IMPDH2	0.814011034	4.33E-30
UCS	IUPHAR	RPL41	SLC27A5	0.815369411	2.91E-30
UCS	TF	RPL41	REXO4	0.8438032	3.14E-34
UCS	TF	RPL41	ZNF581	0.863418239	1.85E-37
UCS	TSG	RPL41	STUB1	0.80731224	2.92E-29
UCS	TSG	RPL41	GSTP1	0.813626327	4.84E-30
UCS	TSG	RPL41	PHB	0.815250211	3.02E-30
UCS	TSG	RPL41	TSSC4	0.840246058	1.08E-33
UVM	CGC	RPL41	NACA	0.856866332	3.77E-24
UVM	IUPHAR	RPL41	LETMD1	0.810461457	8.45E-20
UVM	TF	RPL41	ZNF581	0.80558885	2.06E-19
UVM	TSG	RPL41	GNB2L1	0.84045633	1.87E-22

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
THCA	RPL41	RPL24	1.06284306986844	0.000144459266043069
HNSC	RPL41	RPL6	2.22149016292113	0.000172794781747143
LUAD	RPL41	RPL38	-1.66722943744988	0.000257795914027732
LUSC	RPL41	RPL38	-2.00110253296947	0.00049723236196648
BRCA	RPL41	RPL39	-1.41219628848121	0.00163371967664225
KICH	RPL41	RPL19	1.36901182894089	0.00250792503356934
LUSC	RPL41	RPL39	-2.23543914303094	0.00457577784727754
LUAD	RPL41	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPL41	RPL31	1.09436372419291	0.0152379297688856
LUAD	RPL41	RPS26	-1.30179981165725	0.0163893452361939
PRAD	RPL41	RPL31	1.37417394483053	0.0209655998648434
PRAD	RPL41	RPL39	-2.63448396305036	0.0291755363147523
PRAD	RPL41	RPL38	-1.37307294389303	0.0319785302138518
THCA	RPL41	RPL39	-1.21516043459116	0.0375744128896741
LUSC	RPL41	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPL41	RPL19	-2.73485271276676	1.33980982873695e-10
LUAD	RPL41	RPL30	-1.98579595284099	1.50488235365288e-05
KIRC	RPL41	RPL38	-2.47198269993031	2.66680331214666e-11
KIRP	RPL41	RPL38	-2.05925877790715	4.97791916131974e-07
KIRC	RPL41	RPL11	-5.47536848868151	6.13619476098216e-10
KIRP	RPL41	RPL6	-1.52645217188093	7.40401446819306e-05
LUSC	RPL41	RPL30	-2.27386662283158	9.09971457907932e-05
KIRC	RPL41	RPL30	-1.65763742142219	9.40007073737459e-12
KIRC	RPL41	RPL24	-2.29123283250518	9.9540413319149e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL41

IKBKG, MAPK14, PRNP, APP, SRPK2, NUPR1, DAPK1, SDCBP2, HNRNPH1,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL41	BRCA	chr12	56511292	56511292	G	C	Missense_Mutation	p.R21T	4
RPL41	SARC	chr12	56511286	56511286	A	T	Missense_Mutation		2
RPL41	SARC	chr12	56511286	56511286	A	T	Missense_Mutation	p.K19M	2
RPL41	ESCA	chr12	56510561	56510561	A	G	RNA	NULL	1
RPL41	LIHC	chr12	56511279	56511279	A	G	Missense_Mutation		1
RPL41	LUAD	chr12	56511295	56511296	AG	-	Frame_Shift_Del	p.Q22fs	1
RPL41	BLCA	chr12	56510496	56510496	C	T	Missense_Mutation		1
RPL41	BLCA	chr12	56510503	56510503	C	T	Missense_Mutation		1
RPL41	BLCA	chr12	56510574	56510574	G	C	Translation_Start_Site		1
RPL41	BLCA	chr12	56510574	56510574	G	C	Translation_Start_Site	p.M1I	1
RPL41	CESC	chr12	56510565	56510565	C	G	Missense_Mutation		1
RPL41	CESC	chr12	56510565	56510565	C	G	RNA	NULL	1
RPL41	ESCA	chr12	56510435	56510435	T	-	RNA	NULL	1

Copy number variation (CNV) of RPL41
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPL41
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
72698	N/A	AK023340	CTTNBP2NL	chr1	112999518	+	RPL41	chr12	56511502	+
72698	N/A	EC575283	GRM5	chr11	88300013	-	RPL41	chr12	56511345	+
72698	N/A	EC458238	LINC00624	chr1	146972962	+	RPL41	chr12	56510971	+
72698	STAD	TCGA-EQ-A4SO-01A	MRPL54	chr19	3762816	+	RPL41	chr12	56511266	+
72707	N/A	AA316918	RBFOX2	chr22	36234322	-	RPL41	chr12	56510558	+
72698	N/A	EC521372	RP11-146F11.5	chr16	30599056	+	RPL41	chr12	56511263	+
92661	LAML	TCGA-AB-2979_631TVAAXX_4	RPL41	chr12	56510577	+	CD74	chr5	149792311	-
92913	N/A	AA164526	RPL41	chr12	56511476	-	DGKI	chr7	137198769	+
92913	N/A	EC440666	RPL41	chr12	56510996	+	DGKI	chr7	137198565	+
99269	STAD	TCGA-HU-8604	RPL41	chr12	56510583	+	GRB7	chr17	37898504	+
80325	OV	TCGA-04-1341-01A	RPL41	chr12	56510582	+	IGFBP2	chr2	217498140	+
80325	OV	TCGA-29-2428-01A	RPL41	chr12	56510584	+	IGFBP2	chr2	217498142	+
100872	N/A	AA640379	RPL41	chr12	56510971	-	IL6ST	chr5	55240869	-
100872	N/A	BG030834	RPL41	chr12	56511605	+	IL6ST	chr5	55240470	+
98078	N/A	EC457078	RPL41	chr12	56511514	-	NAA25	chr12	112541140	+
94777	GBM	TCGA-06-5856-01A	RPL41	chr12	56510995	+	NACA	chr12	57108471	-
102869	N/A	AA164525	RPL41	chr12	56511395	-	RBFOX2	chr22	36234459	-
102869	N/A	BF343594	RPL41	chr12	56511613	+	RBFOX2	chr22	36234718	-
102869	N/A	EC558913	RPL41	chr12	56510971	-	RBFOX2	chr22	36234635	+
83045	N/A	AA761029	RPL41	chr12	56511313	-	RPL24	chr3	101404740	-
95099	BLCA	TCGA-DK-AA6P-01A	RPL41	chr12	56510583	+	SMARCC2	chr12	56580024	-
96590	N/A	T27245	RPL41	chr12	56511022	-	UCP2	chr11	73685974	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
SARC	RPL41	0.00825385173920196	0.22
COAD	RPL41	0.0408311377639489	1
LGG	RPL41	0.0419361040743692	1
KIRC	RPL41	3.69269679295766e-05	0.001

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPL41	0.0106724367144579	0.35

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source