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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPLP2 (NCBI Gene ID:6181)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPLP2
	Gene ID: 6181
	Gene Symbol	RPLP2
	Gene ID	6181
	Gene Name	ribosomal protein lateral stalk subunit P2
	Synonyms	D11S2243E\|LP2\|P2\|RPP2
	Cytomap	11p15.5
	Type of Gene	protein-coding
	Description	60S acidic ribosomal protein P2acidic ribosomal phosphoprotein P2large ribosomal subunit protein P2renal carcinoma antigen NY-REN-44ribosomal protein, large, P2
	Modification date	20200313
	UniProtAcc	P05387

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0006414	Translational elongation
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPLP2[title] AND translation [title] AND human.'

Gene	Title	PMID
RPLP2	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000321153	811596	811645	Frame-shift
ENST00000530797	811596	811645	Frame-shift
ENST00000321153	812534	812633	In-frame
ENST00000530797	812534	812633	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000530797	812534	812633	654	424	522	115	57	90
ENST00000321153	812534	812633	798	567	665	115	57	90

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P05387	57	90	1	115	Chain	ID=PRO_0000157640;Note=60S acidic ribosomal protein P2
P05387	57	90	1	115	Chain	ID=PRO_0000157640;Note=60S acidic ribosomal protein P2
P05387	57	90	79	79	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:18691976,ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:24275569;Dbxref=PMID:18669648,PMID:18691976,PMID:19690332,PMID:20068231,PMID:24275569
P05387	57	90	79	79	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:18691976,ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:24275569;Dbxref=PMID:18669648,PMID:18691976,PMID:19690332,PMID:20068231,PMID:24275569
P05387	57	90	86	86	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:23186163,ECO:0000244\|PubMed:24275569;Dbxref=PMID:18669648,PMID:23186163,PMID:24275569
P05387	57	90	86	86	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:23186163,ECO:0000244\|PubMed:24275569;Dbxref=PMID:18669648,PMID:23186163,PMID:24275569
P05387	57	90	59	61	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2LBF
P05387	57	90	59	61	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2LBF
P05387	57	90	63	66	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4BEH
P05387	57	90	63	66	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4BEH

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KICH	RPLP2	-2.79941030721041	0.00250792503356934
COAD	RPLP2	1.74101665732582	0.0334101617336274
KIRC	RPLP2	-1.31294149421946	3.74941832864519e-08
KIRP	RPLP2	-1.33740048133375	6.0301274061203e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
KIRP	RPLP2	0.025119111	0.03134067
KICH	RPLP2	0.035368816	0.04821998

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPLP2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
ACC	Cell metabolism gene	RPLP2	FAU	0.818328024	3.32E-20
CHOL	Cell metabolism gene	RPLP2	SNRPD2	0.820990682	4.98E-12
CHOL	Epifactor	RPLP2	FBL	0.803193504	3.16E-11
DLBC	Cell metabolism gene	RPLP2	HSCB	0.801046043	8.09E-12
DLBC	Cell metabolism gene	RPLP2	B3GAT3	0.802441468	6.99E-12
DLBC	Cell metabolism gene	RPLP2	DPM2	0.807314272	4.17E-12
DLBC	Cell metabolism gene	RPLP2	POLE4	0.808433705	3.69E-12
DLBC	Cell metabolism gene	RPLP2	DGUOK	0.811492574	2.64E-12
DLBC	Cell metabolism gene	RPLP2	TOMM7	0.811854892	2.54E-12
DLBC	Cell metabolism gene	RPLP2	PSMC3	0.811988944	2.50E-12
DLBC	Cell metabolism gene	RPLP2	EXOSC4	0.816166501	1.56E-12
DLBC	Cell metabolism gene	RPLP2	GEMIN7	0.826060114	4.91E-13
DLBC	Cell metabolism gene	RPLP2	PSMC5	0.830999625	2.68E-13
DLBC	Cell metabolism gene	RPLP2	TIMM13	0.836151904	1.39E-13
DLBC	Cell metabolism gene	RPLP2	POLR2I	0.844633554	4.52E-14
DLBC	Cell metabolism gene	RPLP2	PTDSS2	0.84739235	3.09E-14
DLBC	Cell metabolism gene	RPLP2	TOMM22	0.850403272	2.02E-14
DLBC	Cell metabolism gene	RPLP2	PSMD13	0.85102803	1.85E-14
DLBC	Cell metabolism gene	RPLP2	PSMB3	0.85373108	1.25E-14
DLBC	Cell metabolism gene	RPLP2	POLR2F	0.85547327	9.68E-15
DLBC	Cell metabolism gene	RPLP2	TIMM9	0.856502694	8.31E-15
DLBC	Cell metabolism gene	RPLP2	POLR2J	0.85653664	8.27E-15
DLBC	Cell metabolism gene	RPLP2	POLR2L	0.863819244	2.71E-15
DLBC	Cell metabolism gene	RPLP2	GFER	0.87524358	4.10E-16
DLBC	Cell metabolism gene	RPLP2	NME2	0.877936929	2.56E-16
DLBC	Cell metabolism gene	RPLP2	SNRPD2	0.882975041	1.03E-16
DLBC	Cell metabolism gene	RPLP2	PFDN5	0.905719664	9.17E-19
DLBC	Cell metabolism gene	RPLP2	FAU	0.926120765	4.21E-21
DLBC	CGC	RPLP2	COX6C	0.800749309	8.34E-12
DLBC	CGC	RPLP2	HRAS	0.83857381	1.02E-13
DLBC	Epifactor	RPLP2	RBX1	0.803694823	6.13E-12
DLBC	Epifactor	RPLP2	PRPF31	0.804229497	5.79E-12
DLBC	Epifactor	RPLP2	HMG20B	0.805121864	5.27E-12
DLBC	Epifactor	RPLP2	MBD3	0.811907129	2.52E-12
DLBC	Epifactor	RPLP2	EXOSC4	0.816166501	1.56E-12
DLBC	Epifactor	RPLP2	FBL	0.837948612	1.10E-13
DLBC	Epifactor	RPLP2	ZNHIT1	0.839205239	9.36E-14
DLBC	Epifactor	RPLP2	DMAP1	0.844104809	4.86E-14
DLBC	Epifactor	RPLP2	BRMS1	0.844759926	4.44E-14
DLBC	Epifactor	RPLP2	TAF10	0.871922951	7.23E-16
DLBC	IUPHAR	RPLP2	ATG4B	0.804056912	5.90E-12
DLBC	IUPHAR	RPLP2	SLC25A26	0.815158942	1.75E-12
DLBC	IUPHAR	RPLP2	MMP24	0.820477316	9.52E-13
DLBC	IUPHAR	RPLP2	HRAS	0.83857381	1.02E-13
DLBC	IUPHAR	RPLP2	SIRT3	0.851121186	1.82E-14
DLBC	TF	RPLP2	REXO4	0.800773444	8.32E-12
DLBC	TF	RPLP2	HMG20B	0.805121864	5.27E-12
DLBC	TF	RPLP2	MBD3	0.811907129	2.52E-12
DLBC	TF	RPLP2	ZNF408	0.815914278	1.61E-12
DLBC	TF	RPLP2	ZNF444	0.833386008	1.98E-13
DLBC	TF	RPLP2	THAP3	0.847356511	3.10E-14
DLBC	TF	RPLP2	THAP4	0.848972904	2.47E-14
DLBC	TF	RPLP2	THAP7	0.86649531	1.77E-15
DLBC	TF	RPLP2	NME2	0.877936929	2.56E-16
DLBC	TSG	RPLP2	PARK7	0.828765704	3.53E-13
DLBC	TSG	RPLP2	BRMS1	0.844759926	4.44E-14
DLBC	TSG	RPLP2	GNB2L1	0.845467022	4.03E-14
DLBC	TSG	RPLP2	SIRT3	0.851121186	1.82E-14
DLBC	TSG	RPLP2	TSSC4	0.869497473	1.08E-15
DLBC	TSG	RPLP2	GADD45GIP1	0.907843229	5.56E-19
GBM	Cell metabolism gene	RPLP2	LSM2	0.808147705	6.23E-41
GBM	Cell metabolism gene	RPLP2	SSR4	0.816544169	2.04E-42
GBM	Cell metabolism gene	RPLP2	FAU	0.842175555	1.81E-47
HNSC	Cell metabolism gene	RPLP2	POLR2L	0.804415494	1.16E-129
KICH	Cell metabolism gene	RPLP2	FAU	0.816772067	5.67E-23
KIRP	Cell metabolism gene	RPLP2	POLR2I	0.806210591	3.71E-75
KIRP	Cell metabolism gene	RPLP2	PSMD13	0.827196055	2.37E-82
KIRP	Cell metabolism gene	RPLP2	SNRPD2	0.871638108	2.01E-101
KIRP	Cell metabolism gene	RPLP2	FAU	0.910281397	5.53E-125
KIRP	Epifactor	RPLP2	FBL	0.81314615	1.96E-77
KIRP	TF	RPLP2	DRAP1	0.816894972	1.05E-78
KIRP	TSG	RPLP2	GADD45GIP1	0.840204932	2.55E-87
LAML	Cell metabolism gene	RPLP2	FAU	0.814619965	2.62E-42
LGG	Cell metabolism gene	RPLP2	FAU	0.86904809	1.68E-163
LIHC	Cell metabolism gene	RPLP2	FAU	0.811481147	2.87E-100
LIHC	Cell metabolism gene	RPLP2	PFDN5	0.835779776	1.12E-111
LIHC	Epifactor	RPLP2	FBL	0.828363299	5.25E-108
MESO	Cell metabolism gene	RPLP2	FAU	0.819913709	2.69E-22
PAAD	Cell metabolism gene	RPLP2	FAU	0.836539173	3.59E-49
PAAD	Epifactor	RPLP2	TAF10	0.81917795	1.44E-45
PRAD	Cell metabolism gene	RPLP2	GFER	0.806583891	3.19E-127
PRAD	Cell metabolism gene	RPLP2	TIMM13	0.807794376	6.85E-128
PRAD	Cell metabolism gene	RPLP2	ZNRD1	0.812994711	8.14E-131
PRAD	Cell metabolism gene	RPLP2	NME2	0.822195201	3.20E-136
PRAD	Cell metabolism gene	RPLP2	PFDN5	0.822836403	1.31E-136
PRAD	Cell metabolism gene	RPLP2	PGLS	0.824462472	1.33E-137
PRAD	Cell metabolism gene	RPLP2	PSMB7	0.834724671	4.15E-144
PRAD	Cell metabolism gene	RPLP2	POLR2F	0.845073672	3.87E-151
PRAD	Cell metabolism gene	RPLP2	TOMM7	0.845154137	3.39E-151
PRAD	Cell metabolism gene	RPLP2	POLR2I	0.865085079	2.53E-166
PRAD	Cell metabolism gene	RPLP2	SNRPD2	0.886128231	3.54E-185
PRAD	Cell metabolism gene	RPLP2	FAU	0.904748936	2.89E-205
PRAD	Epifactor	RPLP2	FBL	0.879386323	9.35E-179
PRAD	TF	RPLP2	NME2	0.822195201	3.20E-136
PRAD	TF	RPLP2	ZNF524	0.832651939	9.28E-143
PRAD	TSG	RPLP2	GLTSCR2	0.810366551	2.51E-129
PRAD	TSG	RPLP2	GNB2L1	0.819240792	1.88E-134
PRAD	TSG	RPLP2	GADD45GIP1	0.826275213	1.01E-138
READ	TSG	RPLP2	GADD45GIP1	0.820620316	8.89E-27
TGCT	Cell metabolism gene	RPLP2	FAU	0.804580626	1.11E-36
TGCT	Cell metabolism gene	RPLP2	PSMD13	0.824897076	5.48E-40
THCA	Cell metabolism gene	RPLP2	PGLS	0.809301093	8.04E-134
THCA	Cell metabolism gene	RPLP2	SNRPD2	0.840735126	5.32E-154
THCA	Cell metabolism gene	RPLP2	FAU	0.881900726	2.68E-188
THCA	Epifactor	RPLP2	TAF10	0.810990745	8.28E-135
THCA	TSG	RPLP2	GADD45GIP1	0.804687219	3.55E-131
THCA	TSG	RPLP2	AIP	0.804800148	3.07E-131
THCA	TSG	RPLP2	GNB2L1	0.814468915	7.16E-137
THYM	Cell metabolism gene	RPLP2	UROS	0.800413375	1.93E-28
THYM	Cell metabolism gene	RPLP2	TBCB	0.801003054	1.65E-28
THYM	Cell metabolism gene	RPLP2	WBSCR22	0.801748409	1.35E-28
THYM	Cell metabolism gene	RPLP2	NANS	0.801894053	1.30E-28
THYM	Cell metabolism gene	RPLP2	LSM5	0.80429703	6.74E-29
THYM	Cell metabolism gene	RPLP2	PSMD4	0.804298141	6.73E-29
THYM	Cell metabolism gene	RPLP2	TOMM40	0.805178765	5.28E-29
THYM	Cell metabolism gene	RPLP2	PSMC1	0.80550169	4.83E-29
THYM	Cell metabolism gene	RPLP2	APOA1	0.807654168	2.66E-29
THYM	Cell metabolism gene	RPLP2	POLA2	0.809073095	1.78E-29
THYM	Cell metabolism gene	RPLP2	MTX1	0.81193779	7.88E-30
THYM	Cell metabolism gene	RPLP2	SNRPD3	0.814899399	3.34E-30
THYM	Cell metabolism gene	RPLP2	GFER	0.816396398	2.15E-30
THYM	Cell metabolism gene	RPLP2	PSMC5	0.816445637	2.12E-30
THYM	Cell metabolism gene	RPLP2	TIMM17B	0.816464144	2.11E-30
THYM	Cell metabolism gene	RPLP2	IDH3G	0.816918696	1.85E-30
THYM	Cell metabolism gene	RPLP2	DGKZ	0.81769256	1.47E-30
THYM	Cell metabolism gene	RPLP2	PMPCA	0.820473598	6.37E-31
THYM	Cell metabolism gene	RPLP2	GEMIN7	0.822024343	3.98E-31
THYM	Cell metabolism gene	RPLP2	DTYMK	0.822334896	3.62E-31
THYM	Cell metabolism gene	RPLP2	PSME1	0.822349973	3.60E-31
THYM	Cell metabolism gene	RPLP2	EXOSC5	0.82300906	2.94E-31
THYM	Cell metabolism gene	RPLP2	PCYT2	0.823715872	2.37E-31
THYM	Cell metabolism gene	RPLP2	HMBS	0.824145934	2.07E-31
THYM	Cell metabolism gene	RPLP2	GMPPA	0.82650955	9.92E-32
THYM	Cell metabolism gene	RPLP2	GALK1	0.829601202	3.72E-32
THYM	Cell metabolism gene	RPLP2	SRM	0.829641906	3.67E-32
THYM	Cell metabolism gene	RPLP2	UROD	0.829674158	3.63E-32
THYM	Cell metabolism gene	RPLP2	DPM3	0.829741451	3.55E-32
THYM	Cell metabolism gene	RPLP2	OAZ1	0.832053229	1.68E-32
THYM	Cell metabolism gene	RPLP2	POLR2F	0.832830241	1.31E-32
THYM	Cell metabolism gene	RPLP2	LSM4	0.835851337	4.81E-33
THYM	Cell metabolism gene	RPLP2	ITPA	0.836360604	4.06E-33
THYM	Cell metabolism gene	RPLP2	DGUOK	0.840066954	1.15E-33
THYM	Cell metabolism gene	RPLP2	PGP	0.840168929	1.11E-33
THYM	Cell metabolism gene	RPLP2	TALDO1	0.840456651	1.01E-33
THYM	Cell metabolism gene	RPLP2	TIMM10	0.842542861	4.89E-34
THYM	Cell metabolism gene	RPLP2	MTMR14	0.842611765	4.77E-34
THYM	Cell metabolism gene	RPLP2	POLD2	0.843298419	3.75E-34
THYM	Cell metabolism gene	RPLP2	POLR2J	0.843637378	3.33E-34
THYM	Cell metabolism gene	RPLP2	DPM2	0.846370172	1.26E-34
THYM	Cell metabolism gene	RPLP2	EBP	0.84727331	9.09E-35
THYM	Cell metabolism gene	RPLP2	POLR2I	0.849310482	4.33E-35
THYM	Cell metabolism gene	RPLP2	PSMB10	0.851737399	1.76E-35
THYM	Cell metabolism gene	RPLP2	PSMB1	0.854967325	5.20E-36
THYM	Cell metabolism gene	RPLP2	EXOSC4	0.860548569	5.88E-37
THYM	Cell metabolism gene	RPLP2	GUK1	0.861818631	3.53E-37
THYM	Cell metabolism gene	RPLP2	SSR2	0.862811555	2.36E-37
THYM	Cell metabolism gene	RPLP2	POLR2H	0.864382398	1.24E-37
THYM	Cell metabolism gene	RPLP2	LSM2	0.865742262	7.08E-38
THYM	Cell metabolism gene	RPLP2	MVD	0.866550861	5.06E-38
THYM	Cell metabolism gene	RPLP2	FPGS	0.869403244	1.51E-38
THYM	Cell metabolism gene	RPLP2	SMPD2	0.869687016	1.34E-38
THYM	Cell metabolism gene	RPLP2	PSMB7	0.872113093	4.67E-39
THYM	Cell metabolism gene	RPLP2	PHKG2	0.874157277	1.89E-39
THYM	Cell metabolism gene	RPLP2	TIMM50	0.874492806	1.63E-39
THYM	Cell metabolism gene	RPLP2	POLD4	0.878945424	2.14E-40
THYM	Cell metabolism gene	RPLP2	APRT	0.887163838	4.05E-42
THYM	Cell metabolism gene	RPLP2	PGLS	0.889141109	1.49E-42
THYM	Cell metabolism gene	RPLP2	TIMM13	0.890577764	7.13E-43
THYM	Cell metabolism gene	RPLP2	SLC27A5	0.892265271	2.95E-43
THYM	Cell metabolism gene	RPLP2	PSMC3	0.896533975	2.98E-44
THYM	Cell metabolism gene	RPLP2	ACOT8	0.896665571	2.77E-44
THYM	Cell metabolism gene	RPLP2	PSMB3	0.902189281	1.21E-45
THYM	Cell metabolism gene	RPLP2	PSMD13	0.903334449	6.19E-46
THYM	Cell metabolism gene	RPLP2	PFDN5	0.907363493	5.44E-47
THYM	Cell metabolism gene	RPLP2	TIMM8B	0.91720215	8.70E-50
THYM	Cell metabolism gene	RPLP2	SNRPD2	0.918706211	3.03E-50
THYM	Cell metabolism gene	RPLP2	FAU	0.957685416	9.42E-67
THYM	CGC	RPLP2	MAP2K2	0.802029003	1.25E-28
THYM	CGC	RPLP2	ASPSCR1	0.80295776	9.72E-29
THYM	CGC	RPLP2	MGMT	0.824594695	1.80E-31
THYM	CGC	RPLP2	RBM10	0.857451431	1.99E-36
THYM	CGC	RPLP2	SDHAF2	0.884046549	1.89E-41
THYM	CGC	RPLP2	TFPT	0.892059163	3.29E-43
THYM	Epifactor	RPLP2	PAF1	0.802841456	1.00E-28
THYM	Epifactor	RPLP2	EXOSC5	0.82300906	2.94E-31
THYM	Epifactor	RPLP2	ZGPAT	0.829878305	3.40E-32
THYM	Epifactor	RPLP2	RRP8	0.844560223	2.40E-34
THYM	Epifactor	RPLP2	SS18L2	0.846128069	1.37E-34
THYM	Epifactor	RPLP2	DMAP1	0.84657124	1.17E-34
THYM	Epifactor	RPLP2	CXXC1	0.849576656	3.93E-35
THYM	Epifactor	RPLP2	RUVBL2	0.85860135	1.27E-36
THYM	Epifactor	RPLP2	EXOSC4	0.860548569	5.88E-37
THYM	Epifactor	RPLP2	MBD3	0.861446949	4.10E-37
THYM	Epifactor	RPLP2	NOC2L	0.868135034	2.59E-38
THYM	Epifactor	RPLP2	CCDC101	0.872231041	4.43E-39
THYM	Epifactor	RPLP2	PRPF31	0.873078441	3.05E-39
THYM	Epifactor	RPLP2	PPP4C	0.88289716	3.30E-41
THYM	Epifactor	RPLP2	ZNHIT1	0.883203942	2.84E-41
THYM	Epifactor	RPLP2	FBL	0.887094206	4.20E-42
THYM	Epifactor	RPLP2	C17orf49	0.887117777	4.15E-42
THYM	Epifactor	RPLP2	INO80E	0.891689778	3.99E-43
THYM	Epifactor	RPLP2	TFPT	0.892059163	3.29E-43
THYM	Epifactor	RPLP2	SIRT6	0.899309558	6.33E-45
THYM	Epifactor	RPLP2	BRMS1	0.935612382	4.24E-56
THYM	Epifactor	RPLP2	TAF10	0.947845347	1.97E-61
THYM	IUPHAR	RPLP2	MFSD2B	0.800156653	2.07E-28
THYM	IUPHAR	RPLP2	MAP2K2	0.802029003	1.25E-28
THYM	IUPHAR	RPLP2	RNPEPL1	0.815975809	2.44E-30
THYM	IUPHAR	RPLP2	SIRT3	0.819797911	7.82E-31
THYM	IUPHAR	RPLP2	TWF2	0.823458707	2.56E-31
THYM	IUPHAR	RPLP2	DPP7	0.827635825	6.95E-32
THYM	IUPHAR	RPLP2	MAP3K11	0.828026587	6.14E-32
THYM	IUPHAR	RPLP2	MMP24	0.82922267	4.20E-32
THYM	IUPHAR	RPLP2	PSMB1	0.854967325	5.20E-36
THYM	IUPHAR	RPLP2	EGLN2	0.855701706	3.93E-36
THYM	IUPHAR	RPLP2	MVD	0.866550861	5.06E-38
THYM	IUPHAR	RPLP2	SMPD2	0.869687016	1.34E-38
THYM	IUPHAR	RPLP2	PHKG2	0.874157277	1.89E-39
THYM	IUPHAR	RPLP2	SLC27A5	0.892265271	2.95E-43
THYM	IUPHAR	RPLP2	SIRT6	0.899309558	6.33E-45
THYM	Kinase	RPLP2	MAP2K2	0.802029003	1.25E-28
THYM	Kinase	RPLP2	MAP3K11	0.828026587	6.14E-32
THYM	Kinase	RPLP2	PHKG2	0.874157277	1.89E-39
THYM	TF	RPLP2	GLI4	0.800393514	1.94E-28
THYM	TF	RPLP2	ZBTB48	0.801112171	1.60E-28
THYM	TF	RPLP2	PIN1	0.80205752	1.24E-28
THYM	TF	RPLP2	GTF3A	0.803975926	7.36E-29
THYM	TF	RPLP2	ZNF32	0.808757049	1.95E-29
THYM	TF	RPLP2	USF1	0.81892382	1.02E-30
THYM	TF	RPLP2	ETV2	0.82453995	1.83E-31
THYM	TF	RPLP2	ZNF524	0.825622155	1.31E-31
THYM	TF	RPLP2	ZNF668	0.825950329	1.18E-31
THYM	TF	RPLP2	ZGPAT	0.829878305	3.40E-32
THYM	TF	RPLP2	ZNF511	0.830107146	3.16E-32
THYM	TF	RPLP2	ZNF581	0.835386035	5.62E-33
THYM	TF	RPLP2	THAP7	0.836577718	3.77E-33
THYM	TF	RPLP2	RBCK1	0.839739157	1.29E-33
THYM	TF	RPLP2	AKAP8L	0.840314399	1.06E-33
THYM	TF	RPLP2	CXXC1	0.849576656	3.93E-35
THYM	TF	RPLP2	DRAP1	0.854011239	7.49E-36
THYM	TF	RPLP2	ZNF428	0.856396073	3.00E-36
THYM	TF	RPLP2	THAP3	0.858226959	1.47E-36
THYM	TF	RPLP2	ZNF444	0.85829359	1.43E-36
THYM	TF	RPLP2	THYN1	0.859651865	8.40E-37
THYM	TF	RPLP2	MBD3	0.861446949	4.10E-37
THYM	TF	RPLP2	IRF3	0.863284377	1.95E-37
THYM	TF	RPLP2	ZNF787	0.872369035	4.17E-39
THYM	TF	RPLP2	ZNF688	0.884783292	1.32E-41
THYM	TSG	RPLP2	PYCARD	0.800023589	2.15E-28
THYM	TSG	RPLP2	ZBTB48	0.801112171	1.60E-28
THYM	TSG	RPLP2	PIN1	0.80205752	1.24E-28
THYM	TSG	RPLP2	SIRT3	0.819797911	7.82E-31
THYM	TSG	RPLP2	HTRA2	0.82005405	7.24E-31
THYM	TSG	RPLP2	ZNF668	0.825950329	1.18E-31
THYM	TSG	RPLP2	PLEKHO1	0.830480841	2.80E-32
THYM	TSG	RPLP2	PARK7	0.832386575	1.51E-32
THYM	TSG	RPLP2	GABARAP	0.84189414	6.13E-34
THYM	TSG	RPLP2	PFN1	0.845165917	1.94E-34
THYM	TSG	RPLP2	IRF3	0.863284377	1.95E-37
THYM	TSG	RPLP2	GNB2L1	0.875236689	1.17E-39
THYM	TSG	RPLP2	AIP	0.879990162	1.31E-40
THYM	TSG	RPLP2	GADD45GIP1	0.881169602	7.53E-41
THYM	TSG	RPLP2	NPRL2	0.891661887	4.05E-43
THYM	TSG	RPLP2	GLTSCR2	0.89486669	7.38E-44
THYM	TSG	RPLP2	SIRT6	0.899309558	6.33E-45
THYM	TSG	RPLP2	TSSC4	0.921203351	5.03E-51
THYM	TSG	RPLP2	BRMS1	0.935612382	4.24E-56
UCEC	Cell metabolism gene	RPLP2	FAU	0.85135975	1.16E-57
UCS	Cell metabolism gene	RPLP2	UROS	0.800413375	1.93E-28
UCS	Cell metabolism gene	RPLP2	TBCB	0.801003054	1.65E-28
UCS	Cell metabolism gene	RPLP2	WBSCR22	0.801748409	1.35E-28
UCS	Cell metabolism gene	RPLP2	NANS	0.801894053	1.30E-28
UCS	Cell metabolism gene	RPLP2	LSM5	0.80429703	6.74E-29
UCS	Cell metabolism gene	RPLP2	PSMD4	0.804298141	6.73E-29
UCS	Cell metabolism gene	RPLP2	TOMM40	0.805178765	5.28E-29
UCS	Cell metabolism gene	RPLP2	PSMC1	0.80550169	4.83E-29
UCS	Cell metabolism gene	RPLP2	APOA1	0.807654168	2.66E-29
UCS	Cell metabolism gene	RPLP2	POLA2	0.809073095	1.78E-29
UCS	Cell metabolism gene	RPLP2	MTX1	0.81193779	7.88E-30
UCS	Cell metabolism gene	RPLP2	SNRPD3	0.814899399	3.34E-30
UCS	Cell metabolism gene	RPLP2	GFER	0.816396398	2.15E-30
UCS	Cell metabolism gene	RPLP2	PSMC5	0.816445637	2.12E-30
UCS	Cell metabolism gene	RPLP2	TIMM17B	0.816464144	2.11E-30
UCS	Cell metabolism gene	RPLP2	IDH3G	0.816918696	1.85E-30
UCS	Cell metabolism gene	RPLP2	DGKZ	0.81769256	1.47E-30
UCS	Cell metabolism gene	RPLP2	PMPCA	0.820473598	6.37E-31
UCS	Cell metabolism gene	RPLP2	GEMIN7	0.822024343	3.98E-31
UCS	Cell metabolism gene	RPLP2	DTYMK	0.822334896	3.62E-31
UCS	Cell metabolism gene	RPLP2	PSME1	0.822349973	3.60E-31
UCS	Cell metabolism gene	RPLP2	EXOSC5	0.82300906	2.94E-31
UCS	Cell metabolism gene	RPLP2	PCYT2	0.823715872	2.37E-31
UCS	Cell metabolism gene	RPLP2	HMBS	0.824145934	2.07E-31
UCS	Cell metabolism gene	RPLP2	GMPPA	0.82650955	9.92E-32
UCS	Cell metabolism gene	RPLP2	GALK1	0.829601202	3.72E-32
UCS	Cell metabolism gene	RPLP2	SRM	0.829641906	3.67E-32
UCS	Cell metabolism gene	RPLP2	UROD	0.829674158	3.63E-32
UCS	Cell metabolism gene	RPLP2	DPM3	0.829741451	3.55E-32
UCS	Cell metabolism gene	RPLP2	OAZ1	0.832053229	1.68E-32
UCS	Cell metabolism gene	RPLP2	POLR2F	0.832830241	1.31E-32
UCS	Cell metabolism gene	RPLP2	LSM4	0.835851337	4.81E-33
UCS	Cell metabolism gene	RPLP2	ITPA	0.836360604	4.06E-33
UCS	Cell metabolism gene	RPLP2	DGUOK	0.840066954	1.15E-33
UCS	Cell metabolism gene	RPLP2	PGP	0.840168929	1.11E-33
UCS	Cell metabolism gene	RPLP2	TALDO1	0.840456651	1.01E-33
UCS	Cell metabolism gene	RPLP2	TIMM10	0.842542861	4.89E-34
UCS	Cell metabolism gene	RPLP2	MTMR14	0.842611765	4.77E-34
UCS	Cell metabolism gene	RPLP2	POLD2	0.843298419	3.75E-34
UCS	Cell metabolism gene	RPLP2	POLR2J	0.843637378	3.33E-34
UCS	Cell metabolism gene	RPLP2	DPM2	0.846370172	1.26E-34
UCS	Cell metabolism gene	RPLP2	EBP	0.84727331	9.09E-35
UCS	Cell metabolism gene	RPLP2	POLR2I	0.849310482	4.33E-35
UCS	Cell metabolism gene	RPLP2	PSMB10	0.851737399	1.76E-35
UCS	Cell metabolism gene	RPLP2	PSMB1	0.854967325	5.20E-36
UCS	Cell metabolism gene	RPLP2	EXOSC4	0.860548569	5.88E-37
UCS	Cell metabolism gene	RPLP2	GUK1	0.861818631	3.53E-37
UCS	Cell metabolism gene	RPLP2	SSR2	0.862811555	2.36E-37
UCS	Cell metabolism gene	RPLP2	POLR2H	0.864382398	1.24E-37
UCS	Cell metabolism gene	RPLP2	LSM2	0.865742262	7.08E-38
UCS	Cell metabolism gene	RPLP2	MVD	0.866550861	5.06E-38
UCS	Cell metabolism gene	RPLP2	FPGS	0.869403244	1.51E-38
UCS	Cell metabolism gene	RPLP2	SMPD2	0.869687016	1.34E-38
UCS	Cell metabolism gene	RPLP2	PSMB7	0.872113093	4.67E-39
UCS	Cell metabolism gene	RPLP2	PHKG2	0.874157277	1.89E-39
UCS	Cell metabolism gene	RPLP2	TIMM50	0.874492806	1.63E-39
UCS	Cell metabolism gene	RPLP2	POLD4	0.878945424	2.14E-40
UCS	Cell metabolism gene	RPLP2	APRT	0.887163838	4.05E-42
UCS	Cell metabolism gene	RPLP2	PGLS	0.889141109	1.49E-42
UCS	Cell metabolism gene	RPLP2	TIMM13	0.890577764	7.13E-43
UCS	Cell metabolism gene	RPLP2	SLC27A5	0.892265271	2.95E-43
UCS	Cell metabolism gene	RPLP2	PSMC3	0.896533975	2.98E-44
UCS	Cell metabolism gene	RPLP2	ACOT8	0.896665571	2.77E-44
UCS	Cell metabolism gene	RPLP2	PSMB3	0.902189281	1.21E-45
UCS	Cell metabolism gene	RPLP2	PSMD13	0.903334449	6.19E-46
UCS	Cell metabolism gene	RPLP2	PFDN5	0.907363493	5.44E-47
UCS	Cell metabolism gene	RPLP2	TIMM8B	0.91720215	8.70E-50
UCS	Cell metabolism gene	RPLP2	SNRPD2	0.918706211	3.03E-50
UCS	Cell metabolism gene	RPLP2	FAU	0.957685416	9.42E-67
UCS	CGC	RPLP2	MAP2K2	0.802029003	1.25E-28
UCS	CGC	RPLP2	ASPSCR1	0.80295776	9.72E-29
UCS	CGC	RPLP2	MGMT	0.824594695	1.80E-31
UCS	CGC	RPLP2	RBM10	0.857451431	1.99E-36
UCS	CGC	RPLP2	SDHAF2	0.884046549	1.89E-41
UCS	CGC	RPLP2	TFPT	0.892059163	3.29E-43
UCS	Epifactor	RPLP2	PAF1	0.802841456	1.00E-28
UCS	Epifactor	RPLP2	EXOSC5	0.82300906	2.94E-31
UCS	Epifactor	RPLP2	ZGPAT	0.829878305	3.40E-32
UCS	Epifactor	RPLP2	RRP8	0.844560223	2.40E-34
UCS	Epifactor	RPLP2	SS18L2	0.846128069	1.37E-34
UCS	Epifactor	RPLP2	DMAP1	0.84657124	1.17E-34
UCS	Epifactor	RPLP2	CXXC1	0.849576656	3.93E-35
UCS	Epifactor	RPLP2	RUVBL2	0.85860135	1.27E-36
UCS	Epifactor	RPLP2	EXOSC4	0.860548569	5.88E-37
UCS	Epifactor	RPLP2	MBD3	0.861446949	4.10E-37
UCS	Epifactor	RPLP2	NOC2L	0.868135034	2.59E-38
UCS	Epifactor	RPLP2	CCDC101	0.872231041	4.43E-39
UCS	Epifactor	RPLP2	PRPF31	0.873078441	3.05E-39
UCS	Epifactor	RPLP2	PPP4C	0.88289716	3.30E-41
UCS	Epifactor	RPLP2	ZNHIT1	0.883203942	2.84E-41
UCS	Epifactor	RPLP2	FBL	0.887094206	4.20E-42
UCS	Epifactor	RPLP2	C17orf49	0.887117777	4.15E-42
UCS	Epifactor	RPLP2	INO80E	0.891689778	3.99E-43
UCS	Epifactor	RPLP2	TFPT	0.892059163	3.29E-43
UCS	Epifactor	RPLP2	SIRT6	0.899309558	6.33E-45
UCS	Epifactor	RPLP2	BRMS1	0.935612382	4.24E-56
UCS	Epifactor	RPLP2	TAF10	0.947845347	1.97E-61
UCS	IUPHAR	RPLP2	MFSD2B	0.800156653	2.07E-28
UCS	IUPHAR	RPLP2	MAP2K2	0.802029003	1.25E-28
UCS	IUPHAR	RPLP2	RNPEPL1	0.815975809	2.44E-30
UCS	IUPHAR	RPLP2	SIRT3	0.819797911	7.82E-31
UCS	IUPHAR	RPLP2	TWF2	0.823458707	2.56E-31
UCS	IUPHAR	RPLP2	DPP7	0.827635825	6.95E-32
UCS	IUPHAR	RPLP2	MAP3K11	0.828026587	6.14E-32
UCS	IUPHAR	RPLP2	MMP24	0.82922267	4.20E-32
UCS	IUPHAR	RPLP2	PSMB1	0.854967325	5.20E-36
UCS	IUPHAR	RPLP2	EGLN2	0.855701706	3.93E-36
UCS	IUPHAR	RPLP2	MVD	0.866550861	5.06E-38
UCS	IUPHAR	RPLP2	SMPD2	0.869687016	1.34E-38
UCS	IUPHAR	RPLP2	PHKG2	0.874157277	1.89E-39
UCS	IUPHAR	RPLP2	SLC27A5	0.892265271	2.95E-43
UCS	IUPHAR	RPLP2	SIRT6	0.899309558	6.33E-45
UCS	Kinase	RPLP2	MAP2K2	0.802029003	1.25E-28
UCS	Kinase	RPLP2	MAP3K11	0.828026587	6.14E-32
UCS	Kinase	RPLP2	PHKG2	0.874157277	1.89E-39
UCS	TF	RPLP2	GLI4	0.800393514	1.94E-28
UCS	TF	RPLP2	ZBTB48	0.801112171	1.60E-28
UCS	TF	RPLP2	PIN1	0.80205752	1.24E-28
UCS	TF	RPLP2	GTF3A	0.803975926	7.36E-29
UCS	TF	RPLP2	ZNF32	0.808757049	1.95E-29
UCS	TF	RPLP2	USF1	0.81892382	1.02E-30
UCS	TF	RPLP2	ETV2	0.82453995	1.83E-31
UCS	TF	RPLP2	ZNF524	0.825622155	1.31E-31
UCS	TF	RPLP2	ZNF668	0.825950329	1.18E-31
UCS	TF	RPLP2	ZGPAT	0.829878305	3.40E-32
UCS	TF	RPLP2	ZNF511	0.830107146	3.16E-32
UCS	TF	RPLP2	ZNF581	0.835386035	5.62E-33
UCS	TF	RPLP2	THAP7	0.836577718	3.77E-33
UCS	TF	RPLP2	RBCK1	0.839739157	1.29E-33
UCS	TF	RPLP2	AKAP8L	0.840314399	1.06E-33
UCS	TF	RPLP2	CXXC1	0.849576656	3.93E-35
UCS	TF	RPLP2	DRAP1	0.854011239	7.49E-36
UCS	TF	RPLP2	ZNF428	0.856396073	3.00E-36
UCS	TF	RPLP2	THAP3	0.858226959	1.47E-36
UCS	TF	RPLP2	ZNF444	0.85829359	1.43E-36
UCS	TF	RPLP2	THYN1	0.859651865	8.40E-37
UCS	TF	RPLP2	MBD3	0.861446949	4.10E-37
UCS	TF	RPLP2	IRF3	0.863284377	1.95E-37
UCS	TF	RPLP2	ZNF787	0.872369035	4.17E-39
UCS	TF	RPLP2	ZNF688	0.884783292	1.32E-41
UCS	TSG	RPLP2	PYCARD	0.800023589	2.15E-28
UCS	TSG	RPLP2	ZBTB48	0.801112171	1.60E-28
UCS	TSG	RPLP2	PIN1	0.80205752	1.24E-28
UCS	TSG	RPLP2	SIRT3	0.819797911	7.82E-31
UCS	TSG	RPLP2	HTRA2	0.82005405	7.24E-31
UCS	TSG	RPLP2	ZNF668	0.825950329	1.18E-31
UCS	TSG	RPLP2	PLEKHO1	0.830480841	2.80E-32
UCS	TSG	RPLP2	PARK7	0.832386575	1.51E-32
UCS	TSG	RPLP2	GABARAP	0.84189414	6.13E-34
UCS	TSG	RPLP2	PFN1	0.845165917	1.94E-34
UCS	TSG	RPLP2	IRF3	0.863284377	1.95E-37
UCS	TSG	RPLP2	GNB2L1	0.875236689	1.17E-39
UCS	TSG	RPLP2	AIP	0.879990162	1.31E-40
UCS	TSG	RPLP2	GADD45GIP1	0.881169602	7.53E-41
UCS	TSG	RPLP2	NPRL2	0.891661887	4.05E-43
UCS	TSG	RPLP2	GLTSCR2	0.89486669	7.38E-44
UCS	TSG	RPLP2	SIRT6	0.899309558	6.33E-45
UCS	TSG	RPLP2	TSSC4	0.921203351	5.03E-51
UCS	TSG	RPLP2	BRMS1	0.935612382	4.24E-56
UVM	Cell metabolism gene	RPLP2	PRKCSH	0.81336984	4.91E-20
UVM	Cell metabolism gene	RPLP2	MPST	0.839304935	2.42E-22
UVM	Cell metabolism gene	RPLP2	FAU	0.903123017	2.29E-30
UVM	CGC	RPLP2	TRAF7	0.837675466	3.47E-22
UVM	Epifactor	RPLP2	TRIM28	0.809314815	1.04E-19
UVM	Epifactor	RPLP2	FBL	0.88150383	3.87E-27
UVM	IUPHAR	RPLP2	TRIM28	0.809314815	1.04E-19
UVM	IUPHAR	RPLP2	MPST	0.839304935	2.42E-22
UVM	Kinase	RPLP2	TRIM28	0.809314815	1.04E-19
UVM	TF	RPLP2	ZNF581	0.87015519	1.10E-25
UVM	TSG	RPLP2	GNB2L1	0.828914491	2.26E-21
UVM	TSG	RPLP2	GLTSCR2	0.844331121	7.75E-23

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPLP2	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPLP2	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPLP2	RPS16	-1.35957043617517	0.00019507110118866
STAD	RPLP2	RPS23	1.85076760664576	0.000364991836249828
COAD	RPLP2	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPLP2	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPLP2	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPLP2	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPLP2	RPL19	1.36901182894089	0.00250792503356934
KICH	RPLP2	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPLP2	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPLP2	RPS16	-6.16322798156577	0.0115764821363307
LUSC	RPLP2	RPS23	1.46751169891047	0.0174932185880974
BLCA	RPLP2	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPLP2	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPLP2	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPLP2	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPLP2	RPL19	-2.14669889516666	0.044366810398747
UCEC	RPLP2	RPS23	-2.03658159814007	0.046875
KIRC	RPLP2	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPLP2	RPS12	-4.91239327478244	1.85340619742495e-09
KIRC	RPLP2	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPLP2	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPLP2	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPLP2	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPLP2	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRP	RPLP2	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPLP2	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPLP2	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPLP2

RPLP1, RPLP2, H2AFX, UBC, Mapk13, ARRB2, SIRT7, CUL3, CUL4A, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, RPS11, RPS17, RPS25, RPS26, RPS8, RPL5, RPS7, RPS15A, RPS3A, RPS23, RPL23, RPS4X, RPS24, RPS13, RPS16, RPS5, RPS6, RPS15, RPS2, RPL14, RPS3, RPSA, RPS28, RPS14, RPLP0, RPS20, RPS21, UBA52, HNRNPU, HNRNPA1, RPLP0P6, HNRNPA3, MRPL12, RPS27L, CTNNB1, PA2G4, FN1, UBL4A, PAN2, CD81, IGSF8, ICAM1, MAPK8, YWHAQ, FBXO6, CNDP2, NANS, NPEPPS, AURKA, CEP250, CEP57, TP53, TUBG1, TUBGCP2, TUBGCP4, CUL7, RPL8, DDX24, MRPS21, RPL10, RPL10A, RPL11, RPL12, RPL15, RPL18A, RPL23A, RPL27A, RPL31, RPL35A, RPL37A, RPL7, RPL9, ATP1B2, ATP1B3, COX5B, PABPC1, RPL13A, RPL18, RPL19, RPL21, RPL22, RPL24, RPL26, RPL26L1, RPL27, RPL28, RPL3, RPL30, RPL35, RPL36, RPL38, RPL4, RPL6, RPL7A, RPS10, RPS27, RPS9, SSR3, RPS18, RPS19, LOC101929876, PTEN, EWSR1, SRPK2, MCM2, C3orf17, ZNF746, EGFR, CNBP, RRS1, MAGEB10, SART3, MECP2, RBM34, DGCR8, CYLD, INO80B, TRIM25, BRCA1, HDAC6, CFTR, BDP1, GTF2H4, LEO1, LIAS, MBTPS2, PSMC2, USE1, RIPK4, TMPO, PPP1CC, PCBP1, JUP, UBE2M, PRPF8, EFTUD2, AAR2, PIH1D1, TNIP2, AKTIP, RNF4, CHD3, CHD4, LARP7, TNF, FAM188B, SPDL1, RIOK1, ESR2, HEXIM1, MEPCE, DPF2, PPT1, RECQL4, REST, ZFP36L2, MYC, RPS6KB2, METTL14, KIAA1429, RC3H1, RC3H2, ATG16L1, PHB, RBX1, USP14, NR2C2, VRK1, VRK3, HIST1H4A, LINC00839, SNRNP70, ITFG1, HMGB1, BIRC3, STAU1, WWP2, Dnajc17, PARK2, LRRK2, CMTR1, ARIH2, PLEKHA4, FANCD2, NGB, ZC3H18, CDC42, SRC, EMC4, MROH2B, C7orf72, BEST1, GPATCH11, SUPT20H, PKHD1, UNC13C, CIT, ANLN, AURKB, CHMP4B, ECT2, KIF14, KIF20A, KIF23, PRC1, FASN, LDLR, LRRC59, INS, NINL, RBM45, Apc2, RBM39, FBP1, RIN3, DNAJC15, DNAJC1, DNAJC25, DNAJC2, DNAJC16, DNAJC19, SETD8, KDM2A, HIST1H2AI, SMYD3, BAG5, UFL1, DDRGK1, IMPDH2, UBQLN1, FZR1, WDR5, NUDCD2, SRP14, PNMAL1, ZNF668, SRSF1, UTP23, DDX21, ZBTB47, NPM3, SRSF5, H2AFB2, PRKRA, NOP2, H2AFY2, H2AFB3, ADARB1, HIST1H1B, CCDC140, KAL1, MYBBP1A, LYAR, SRSF6, ZNF48, ILF3, IL17B, NEIL1, MAGEB2, SURF6, RPL13, LIN28A, NPM1, ZC3H3, HIST1H2AM, ZNF346, HIST1H1E, ABT1, RNF151, HIST1H1A, SPRTN, BTF3, FBXW7, NLRP7, MAP1LC3B, CALCOCO2, N, SIRT6, RBBP5, MEN1, RB1CC1,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPLP2	BRCA	chr11	812762	812762	G	C	Missense_Mutation	p.E92Q	3
RPLP2	LUAD	chr11	812597	812597	T	C	Missense_Mutation	p.S79P	2
RPLP2	SKCM	chr11	810284	810284	C	T	Missense_Mutation	p.S17F	2
RPLP2	SKCM	chr11	812574	812574	T	A	Missense_Mutation	p.V71E	2
RPLP2	STAD	chr11	812594	812594	G	T	Missense_Mutation	p.G78C	2
RPLP2	STAD	chr11	812614	812614	T	G	Silent	p.A84A	2
RPLP2	BLCA	chr11	810271	810271	G	A	Missense_Mutation	p.G13R	1
RPLP2	PAAD	chr11	812603	812603	G	T	Missense_Mutation		1
RPLP2	PAAD	chr11	812603	812603	G	T	Missense_Mutation	p.A81S	1
RPLP2	HNSC	chr11	812565	812565	G	T	Missense_Mutation		1
RPLP2	SARC	chr11	811608	811608	G	T	Missense_Mutation		1
RPLP2	HNSC	chr11	812565	812565	G	T	Missense_Mutation	p.G68V	1
RPLP2	KIRP	chr11	810286	810286	C	A	Missense_Mutation		1
RPLP2	LIHC	chr11	812569	812569	G	T	Silent	p.G69G	1
RPLP2	STAD	chr11	812778	812780	AGA	-	In_Frame_Del	p.97_97del	1
RPLP2	LIHC	chr11	810266	810266	C	-	Frame_Shift_Del	p.A11fs	1
RPLP2	LIHC	chr11	811617	811617	A	-	Frame_Shift_Del	p.G48fs	1
RPLP2	LUAD	chr11	811600	811600	A	T	Missense_Mutation	p.I43F	1
RPLP2	STAD	chr11	812778	812780	AGA	-	In_Frame_Del	p.E97del	1
RPLP2	BLCA	chr11	810271	810271	G	A	Missense_Mutation		1
RPLP2	LUAD	chr11	810350	810350	T	G	Missense_Mutation	p.L39R	1
RPLP2	BLCA	chr11	810264	810264	T	C	Silent	p.A10A	1

Copy number variation (CNV) of RPLP2
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPLP2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
102045	N/A	BG222637	CABLES1	chr18	20782945	-	RPLP2	chr11	812874	-
102045	N/A	BG230701	DENND5A	chr11	9198632	-	RPLP2	chr11	811189	-
102045	N/A	AA536030	FAM155A	chr13	107940892	+	RPLP2	chr11	812874	-
102045	N/A	BQ335002	LTA4H	chr12	96394856	-	RPLP2	chr11	812822	-
102045	N/A	BP393246	NFYC	chr1	41235058	-	RPLP2	chr11	809991	+
102045	ESCA	TCGA-L5-A8NW-01A	ORC2	chr2	201790559	-	RPLP2	chr11	809992	+
102045	LUAD	TCGA-73-4658-01A	PNPLA2	chr11	818958	+	RPLP2	chr11	809992	+
102045	LUAD	TCGA-73-4658-01A	PNPLA2	chr11	818958	+	RPLP2	chr11	810234	+
91487	PRAD	TCGA-EJ-7125-01A	RPLP2	chr11	812874	-	ACPP	chr3	132036211	+
81606	N/A	BF339211	RPLP2	chr11	812875	+	BAG4	chr8	38056030	-
77184	N/A	DB355988	RPLP2	chr11	810294	-	BOD1L1	chr4	13601214	+
101483	N/A	CA425105	RPLP2	chr11	810303	-	CALR	chr19	13054597	-
89285	N/A	BF525890	RPLP2	chr11	812874	+	CERK	chr22	47100720	+
77184	N/A	AA535645	RPLP2	chr11	812874	+	CES5AP1	chr22	23719768	+
81834	UCEC	TCGA-EY-A3L3-01A	RPLP2	chr11	812633	+	DEAF1	chr11	644654	-
77184	N/A	CF124316	RPLP2	chr11	812876	+	DPY19L4	chr8	95741820	+
102518	COAD	TCGA-AZ-4308-01A	RPLP2	chr11	810330	+	DTWD2	chr5	118324071	-
98325	N/A	AW020424	RPLP2	chr11	812873	+	GPC6	chr13	94618931	-
96675	N/A	AA367796	RPLP2	chr11	812574	-	HBB	chr11	5248258	-
77184	N/A	BQ027739	RPLP2	chr11	812551	-	HLA-DPA1	chr6	33032845	-
103173	N/A	DB193761	RPLP2	chr11	811645	+	MED15	chr22	20922848	+
77184	N/A	CB529802	RPLP2	chr11	810303	-	MNDA	chr1	158817536	-
98891	Non-Cancer	TCGA-AX-A1CF-11A	RPLP2	chr11	810039	+	PDE6A	chr5	149246806	-
77184	N/A	AA733088	RPLP2	chr11	810275	-	PEG10	chr7	94296378	-
94992	N/A	AI541450	RPLP2	chr11	812874	+	POLR2F	chr22	38355830	-
102045	N/A	BF813426	RPLP2	chr11	809968	-	RPLP2	chr11	810304	+
90724	N/A	CD370735	RPLP2	chr11	809999	-	RPN1	chr3	128339108	+
86810	N/A	AV692578	RPLP2	chr11	812874	+	SMCHD1	chr18	2660494	-
85617	N/A	AW023378	RPLP2	chr11	812874	+	SPATS2	chr12	49820009	-
99862	N/A	AA541347	RPLP2	chr11	812876	+	SPN	chr16	29681192	+
92948	N/A	AW021091	RPLP2	chr11	812874	+	SUN3	chr7	48059568	+
94770	LUAD	TCGA-67-3771	RPLP2	chr11	811645	+	TALDO1	chr11	755878	+
94770	LUAD	TCGA-67-3771-01A	RPLP2	chr11	811645	+	TALDO1	chr11	755879	+
96425	N/A	AW023255	RPLP2	chr11	812873	+	UBR1	chr15	43384094	+
102045	STAD	TCGA-BR-A44U	RSF1	chr11	77436589	-	RPLP2	chr11	812759	+
102045	N/A	BP431469	SPATS2	chr12	49820009	+	RPLP2	chr11	812874	-
102045	N/A	BC010093	TGFBRAP1	chr2	105889455	-	RPLP2	chr11	810003	+
102045	N/A	N67080	WDPCP	chr2	63446764	-	RPLP2	chr11	812875	-
102045	N/A	AA564088	ZAR1L	chr13	32883150	+	RPLP2	chr11	812876	-
102050	N/A	AK092774	ZNF420	chr19	37529549	+	RPLP2	chr11	810275	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
SARC	RPLP2	0.0268286624345091	0.75

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPLP2	0.00238627676760557	0.079
KICH	RPLP2	0.0189494680232487	0.59
PAAD	RPLP2	0.0120914329694694	0.39

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0006142	Malignant neoplasm of breast	1	CTD_human
C0678222	Breast Carcinoma	1	CTD_human
C1257931	Mammary Neoplasms, Human	1	CTD_human
C4704874	Mammary Carcinoma, Human	1	CTD_human