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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MRPS12 (NCBI Gene ID:6183)

Gene Summary

Gene Summary

Gene Information	Gene Name: MRPS12
	Gene ID: 6183
	Gene Symbol	MRPS12
	Gene ID	6183
	Gene Name	mitochondrial ribosomal protein S12
	Synonyms	MPR-S12\|MT-RPS12\|RPMS12\|RPS12\|RPSM12
	Cytomap	19q13.2
	Type of Gene	protein-coding
	Description	28S ribosomal protein S12, mitochondrialMRP-S12S12mtmitochondrial small ribosomal subunit protein uS12m
	Modification date	20200313
	UniProtAcc	O15235

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0032543	Mitochondrial translation
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MRPS12	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'MRPS12[title] AND translation [title] AND human.'

Gene	Title	PMID
MRPS12	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
COAD	MRPS12	2.11566333114824	0.000125885009765625
ESCA	MRPS12	-1.86248549814506	0.0048828125
HNSC	MRPS12	1.33677139927136	0.0248336488591576
LUAD	MRPS12	-5.3399185683719	1.00823612619819e-08
BRCA	MRPS12	-1.59537235222597	1.66215672512325e-20
LIHC	MRPS12	2.67189430810317	2.56696988045444e-05
KICH	MRPS12	1.48941080926405	3.19480895996094e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
KIRC	MRPS12	-0.066477022	0.001958043
CESC	MRPS12	0.047028635	0.038932644

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MRPS12 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
BRCA	Cell metabolism gene	MRPS12	TOMM40	0.818292999	1.05E-294
BRCA	Cell metabolism gene	MRPS12	TIMM50	0.843373557	0
CESC	Cell metabolism gene	MRPS12	TIMM50	0.809239146	1.15E-72
CHOL	Cell metabolism gene	MRPS12	TIMM50	0.865656828	1.67E-14
CHOL	Cell metabolism gene	MRPS12	TOMM40	0.866985011	1.36E-14
COAD	Cell metabolism gene	MRPS12	SNRPD2	0.811658405	2.42E-78
COAD	Cell metabolism gene	MRPS12	TIMM50	0.852896441	2.59E-94
DLBC	Cell metabolism gene	MRPS12	ACOT8	0.800473399	8.59E-12
DLBC	Cell metabolism gene	MRPS12	PSMC1	0.800801081	8.30E-12
DLBC	Cell metabolism gene	MRPS12	DOHH	0.800993823	8.14E-12
DLBC	Cell metabolism gene	MRPS12	MDH2	0.801658387	7.59E-12
DLBC	Cell metabolism gene	MRPS12	ALDOA	0.80250974	6.94E-12
DLBC	Cell metabolism gene	MRPS12	DHRS4	0.805024794	5.32E-12
DLBC	Cell metabolism gene	MRPS12	PSMB7	0.805207554	5.22E-12
DLBC	Cell metabolism gene	MRPS12	PSMD9	0.805338129	5.15E-12
DLBC	Cell metabolism gene	MRPS12	PSMB1	0.808515977	3.66E-12
DLBC	Cell metabolism gene	MRPS12	TIMM9	0.809171409	3.41E-12
DLBC	Cell metabolism gene	MRPS12	MED16	0.80932215	3.35E-12
DLBC	Cell metabolism gene	MRPS12	PHKG2	0.81012651	3.07E-12
DLBC	Cell metabolism gene	MRPS12	PAFAH1B3	0.811811097	2.55E-12
DLBC	Cell metabolism gene	MRPS12	PTDSS2	0.813492956	2.11E-12
DLBC	Cell metabolism gene	MRPS12	IDH3B	0.815116859	1.76E-12
DLBC	Cell metabolism gene	MRPS12	POLR2E	0.817156869	1.40E-12
DLBC	Cell metabolism gene	MRPS12	HSD17B10	0.817627863	1.32E-12
DLBC	Cell metabolism gene	MRPS12	PMVK	0.821024613	8.93E-13
DLBC	Cell metabolism gene	MRPS12	PMPCA	0.821519059	8.43E-13
DLBC	Cell metabolism gene	MRPS12	FPGS	0.822274198	7.71E-13
DLBC	Cell metabolism gene	MRPS12	MMAB	0.822499186	7.51E-13
DLBC	Cell metabolism gene	MRPS12	VKORC1	0.824506495	5.92E-13
DLBC	Cell metabolism gene	MRPS12	ECHS1	0.828035654	3.86E-13
DLBC	Cell metabolism gene	MRPS12	SNRPE	0.829421369	3.26E-13
DLBC	Cell metabolism gene	MRPS12	SNRPD3	0.829794455	3.11E-13
DLBC	Cell metabolism gene	MRPS12	DPM2	0.830516991	2.84E-13
DLBC	Cell metabolism gene	MRPS12	POLR2L	0.830588545	2.82E-13
DLBC	Cell metabolism gene	MRPS12	TPI1	0.83139966	2.55E-13
DLBC	Cell metabolism gene	MRPS12	POLE4	0.834919458	1.63E-13
DLBC	Cell metabolism gene	MRPS12	POLR2I	0.837455616	1.18E-13
DLBC	Cell metabolism gene	MRPS12	GEMIN7	0.838160458	1.07E-13
DLBC	Cell metabolism gene	MRPS12	PSMA7	0.838562726	1.02E-13
DLBC	Cell metabolism gene	MRPS12	PGLS	0.838720071	9.98E-14
DLBC	Cell metabolism gene	MRPS12	TIMM10	0.839175023	9.40E-14
DLBC	Cell metabolism gene	MRPS12	PGP	0.844012803	4.92E-14
DLBC	Cell metabolism gene	MRPS12	PSMC5	0.845571331	3.97E-14
DLBC	Cell metabolism gene	MRPS12	PSMD13	0.846494392	3.50E-14
DLBC	Cell metabolism gene	MRPS12	TOMM22	0.849600753	2.26E-14
DLBC	Cell metabolism gene	MRPS12	POLR2F	0.851274503	1.78E-14
DLBC	Cell metabolism gene	MRPS12	DTYMK	0.851514151	1.72E-14
DLBC	Cell metabolism gene	MRPS12	POLR2H	0.854328412	1.15E-14
DLBC	Cell metabolism gene	MRPS12	EXOSC5	0.859568052	5.24E-15
DLBC	Cell metabolism gene	MRPS12	LSM4	0.868909517	1.19E-15
DLBC	Cell metabolism gene	MRPS12	SNRPD2	0.871972418	7.17E-16
DLBC	Cell metabolism gene	MRPS12	SNRPB	0.873888015	5.18E-16
DLBC	Cell metabolism gene	MRPS12	UROD	0.874213086	4.90E-16
DLBC	Cell metabolism gene	MRPS12	ITPA	0.875039686	4.25E-16
DLBC	Cell metabolism gene	MRPS12	NME2	0.87562798	3.84E-16
DLBC	Cell metabolism gene	MRPS12	PSMC3	0.877984156	2.54E-16
DLBC	Cell metabolism gene	MRPS12	ATP5G1	0.879452106	1.95E-16
DLBC	Cell metabolism gene	MRPS12	MTX1	0.881312268	1.39E-16
DLBC	Cell metabolism gene	MRPS12	PSMB4	0.884852728	7.23E-17
DLBC	Cell metabolism gene	MRPS12	PSMD4	0.886364119	5.42E-17
DLBC	Cell metabolism gene	MRPS12	PSMB6	0.891817659	1.86E-17
DLBC	Cell metabolism gene	MRPS12	MIF	0.892866749	1.50E-17
DLBC	Cell metabolism gene	MRPS12	TIMM50	0.915787469	7.63E-20
DLBC	Cell metabolism gene	MRPS12	TIMM13	0.918558834	3.64E-20
DLBC	Cell metabolism gene	MRPS12	EXOSC4	0.919897883	2.52E-20
DLBC	Cell metabolism gene	MRPS12	PSMB3	0.923368272	9.46E-21
DLBC	CGC	MRPS12	ASPSCR1	0.804665625	5.53E-12
DLBC	CGC	MRPS12	COX6C	0.808154476	3.80E-12
DLBC	CGC	MRPS12	HRAS	0.809562561	3.26E-12
DLBC	CGC	MRPS12	TFPT	0.841110558	7.27E-14
DLBC	CGC	MRPS12	NTHL1	0.895094183	9.51E-18
DLBC	Epifactor	MRPS12	ZNHIT1	0.808827792	3.54E-12
DLBC	Epifactor	MRPS12	PAF1	0.818335268	1.22E-12
DLBC	Epifactor	MRPS12	PPP4C	0.819598777	1.05E-12
DLBC	Epifactor	MRPS12	BRMS1	0.837251363	1.21E-13
DLBC	Epifactor	MRPS12	TFPT	0.841110558	7.27E-14
DLBC	Epifactor	MRPS12	RBX1	0.853960092	1.21E-14
DLBC	Epifactor	MRPS12	PRPF31	0.85421197	1.17E-14
DLBC	Epifactor	MRPS12	SIRT6	0.856033311	8.91E-15
DLBC	Epifactor	MRPS12	EXOSC5	0.859568052	5.24E-15
DLBC	Epifactor	MRPS12	FBL	0.859726819	5.11E-15
DLBC	Epifactor	MRPS12	MBD3	0.885836683	6.00E-17
DLBC	Epifactor	MRPS12	RUVBL2	0.891434502	2.01E-17
DLBC	Epifactor	MRPS12	EXOSC4	0.919897883	2.52E-20
DLBC	IUPHAR	MRPS12	TPRA1	0.800002884	9.02E-12
DLBC	IUPHAR	MRPS12	SLC25A39	0.804573285	5.59E-12
DLBC	IUPHAR	MRPS12	PSMB1	0.808515977	3.66E-12
DLBC	IUPHAR	MRPS12	HRAS	0.809562561	3.26E-12
DLBC	IUPHAR	MRPS12	PHKG2	0.81012651	3.07E-12
DLBC	IUPHAR	MRPS12	BIRC5	0.815384101	1.71E-12
DLBC	IUPHAR	MRPS12	PMVK	0.821024613	8.93E-13
DLBC	IUPHAR	MRPS12	VKORC1	0.824506495	5.92E-13
DLBC	IUPHAR	MRPS12	SIRT6	0.856033311	8.91E-15
DLBC	IUPHAR	MRPS12	PSMB6	0.891817659	1.86E-17
DLBC	Kinase	MRPS12	PHKG2	0.81012651	3.07E-12
DLBC	TF	MRPS12	THAP4	0.815298887	1.73E-12
DLBC	TF	MRPS12	ZNF653	0.815960341	1.60E-12
DLBC	TF	MRPS12	IRF3	0.816450719	1.51E-12
DLBC	TF	MRPS12	THAP3	0.819896357	1.02E-12
DLBC	TF	MRPS12	THAP7	0.832584283	2.20E-13
DLBC	TF	MRPS12	PIN1	0.860101651	4.83E-15
DLBC	TF	MRPS12	NME2	0.87562798	3.84E-16
DLBC	TF	MRPS12	MBD3	0.885836683	6.00E-17
DLBC	TSG	MRPS12	PARK7	0.801762982	7.51E-12
DLBC	TSG	MRPS12	IRF3	0.816450719	1.51E-12
DLBC	TSG	MRPS12	BRMS1	0.837251363	1.21E-13
DLBC	TSG	MRPS12	DIABLO	0.853129779	1.37E-14
DLBC	TSG	MRPS12	SIRT6	0.856033311	8.91E-15
DLBC	TSG	MRPS12	PIN1	0.860101651	4.83E-15
DLBC	TSG	MRPS12	TSSC4	0.864904412	2.28E-15
DLBC	TSG	MRPS12	PHB	0.91310245	1.52E-19
DLBC	TSG	MRPS12	GADD45GIP1	0.926138224	4.18E-21
GBM	Cell metabolism gene	MRPS12	POLR2I	0.805328161	1.89E-40
GBM	Cell metabolism gene	MRPS12	PSMC4	0.838051648	1.35E-46
GBM	Cell metabolism gene	MRPS12	GEMIN7	0.842850961	1.30E-47
GBM	Cell metabolism gene	MRPS12	SNRPD2	0.849245779	5.05E-49
GBM	Cell metabolism gene	MRPS12	PSMD8	0.869612516	5.49E-54
GBM	TSG	MRPS12	GADD45GIP1	0.840209448	4.74E-47
HNSC	Cell metabolism gene	MRPS12	SNRPD2	0.811035323	1.96E-133
HNSC	Cell metabolism gene	MRPS12	TIMM50	0.849092312	1.89E-158
KICH	Cell metabolism gene	MRPS12	TIMM50	0.847863588	2.97E-26
KICH	Cell metabolism gene	MRPS12	TIMM13	0.847987495	2.87E-26
KIRP	Cell metabolism gene	MRPS12	TIMM13	0.808579382	6.34E-76
KIRP	Cell metabolism gene	MRPS12	TIMM50	0.839558366	4.61E-87
LAML	Cell metabolism gene	MRPS12	TECR	0.802377955	3.53E-40
LAML	Cell metabolism gene	MRPS12	TIMM50	0.808252404	3.51E-41
LAML	Cell metabolism gene	MRPS12	CYC1	0.81214015	7.28E-42
LAML	Cell metabolism gene	MRPS12	APRT	0.813822765	3.64E-42
LAML	Cell metabolism gene	MRPS12	SRM	0.840409515	2.33E-47
LAML	Cell metabolism gene	MRPS12	TOMM40	0.842412789	8.65E-48
LAML	TSG	MRPS12	STUB1	0.815065095	2.18E-42
LAML	TSG	MRPS12	GADD45GIP1	0.820586491	2.10E-43
LGG	Cell metabolism gene	MRPS12	SNRPD2	0.802497793	1.65E-120
LIHC	Cell metabolism gene	MRPS12	TIMM50	0.804958446	1.74E-97
LUAD	Cell metabolism gene	MRPS12	PSMD8	0.808410065	3.16E-134
LUAD	Cell metabolism gene	MRPS12	TIMM50	0.851475327	4.74E-163
LUSC	Cell metabolism gene	MRPS12	TIMM50	0.85167569	9.63E-157
MESO	Cell metabolism gene	MRPS12	TIMM50	0.847329935	4.40E-25
MESO	TSG	MRPS12	GADD45GIP1	0.831972164	1.85E-23
PCPG	Cell metabolism gene	MRPS12	TIMM13	0.815189958	9.50E-46
PCPG	Epifactor	MRPS12	PPP4C	0.805538777	6.51E-44
PRAD	Cell metabolism gene	MRPS12	POLR2L	0.80045815	6.50E-124
PRAD	Cell metabolism gene	MRPS12	GPX1	0.805741237	9.24E-127
PRAD	Cell metabolism gene	MRPS12	SCO2	0.808955286	1.55E-128
PRAD	Cell metabolism gene	MRPS12	PTGES2	0.810009204	3.99E-129
PRAD	Cell metabolism gene	MRPS12	TOMM40	0.811283245	7.64E-130
PRAD	Cell metabolism gene	MRPS12	NME1	0.813183025	6.35E-131
PRAD	Cell metabolism gene	MRPS12	DTYMK	0.815465231	3.08E-132
PRAD	Cell metabolism gene	MRPS12	SNRPD2	0.820299402	4.40E-135
PRAD	Cell metabolism gene	MRPS12	GEMIN7	0.825718804	2.24E-138
PRAD	Cell metabolism gene	MRPS12	POLR2I	0.826012303	1.48E-138
PRAD	Cell metabolism gene	MRPS12	PSMB3	0.830288924	3.05E-141
PRAD	Cell metabolism gene	MRPS12	PGLS	0.836372746	3.40E-145
PRAD	Cell metabolism gene	MRPS12	LSM4	0.838149976	2.22E-146
PRAD	Cell metabolism gene	MRPS12	ATP5G1	0.839636794	2.20E-147
PRAD	Cell metabolism gene	MRPS12	EXOSC4	0.847005868	1.65E-152
PRAD	Cell metabolism gene	MRPS12	HSD17B10	0.868740897	2.32E-169
PRAD	Cell metabolism gene	MRPS12	TIMM13	0.869309855	7.66E-170
PRAD	Cell metabolism gene	MRPS12	TIMM50	0.875783204	1.77E-175
PRAD	CGC	MRPS12	ASPSCR1	0.831468256	5.37E-142
PRAD	Epifactor	MRPS12	PPP4C	0.821743218	5.99E-136
PRAD	Epifactor	MRPS12	EXOSC4	0.847005868	1.65E-152
PRAD	Epifactor	MRPS12	RUVBL2	0.857287792	3.93E-160
PRAD	IUPHAR	MRPS12	PTGES2	0.810009204	3.99E-129
PRAD	TF	MRPS12	ZNF524	0.818060724	9.37E-134
PRAD	TSG	MRPS12	STUB1	0.801643218	1.52E-124
PRAD	TSG	MRPS12	NME1	0.813183025	6.35E-131
PRAD	TSG	MRPS12	GADD45GIP1	0.813455887	4.43E-131
READ	Cell metabolism gene	MRPS12	PSMD8	0.840172175	3.95E-29
READ	Cell metabolism gene	MRPS12	TIMM50	0.92198401	3.09E-44
READ	Epifactor	MRPS12	FBL	0.813264739	5.77E-26
SKCM	Cell metabolism gene	MRPS12	TOMM40	0.851115029	3.48E-134
STAD	Cell metabolism gene	MRPS12	TIMM50	0.826920241	4.47E-114
TGCT	Cell metabolism gene	MRPS12	TOMM40	0.808862893	2.41E-37
TGCT	Cell metabolism gene	MRPS12	PSMB4	0.814640232	2.88E-38
TGCT	Cell metabolism gene	MRPS12	PSMC5	0.814799608	2.71E-38
TGCT	Cell metabolism gene	MRPS12	PSMB1	0.819535046	4.48E-39
TGCT	Cell metabolism gene	MRPS12	EXOSC4	0.819958983	3.81E-39
TGCT	Cell metabolism gene	MRPS12	PSMC4	0.825766174	3.87E-40
TGCT	Cell metabolism gene	MRPS12	TIMM13	0.871937027	1.27E-49
TGCT	CGC	MRPS12	BAX	0.807943311	3.36E-37
TGCT	Epifactor	MRPS12	EXOSC4	0.819958983	3.81E-39
TGCT	IUPHAR	MRPS12	MFSD2B	0.806177661	6.31E-37
TGCT	IUPHAR	MRPS12	PSMB1	0.819535046	4.48E-39
TGCT	TF	MRPS12	ZNF581	0.815481583	2.10E-38
TGCT	TSG	MRPS12	BAX	0.807943311	3.36E-37
THCA	Cell metabolism gene	MRPS12	TIMM50	0.800754342	5.63E-129
THCA	Cell metabolism gene	MRPS12	NME2	0.817165597	1.68E-138
THCA	Cell metabolism gene	MRPS12	EXOSC4	0.820575035	1.33E-140
THCA	Cell metabolism gene	MRPS12	APRT	0.844348016	1.34E-156
THCA	Epifactor	MRPS12	EXOSC4	0.820575035	1.33E-140
THCA	TF	MRPS12	NME2	0.817165597	1.68E-138
THYM	Cell metabolism gene	MRPS12	SEC61G	0.801328519	1.51E-28
THYM	Cell metabolism gene	MRPS12	PSME1	0.804080236	7.15E-29
THYM	Cell metabolism gene	MRPS12	PSMB6	0.806621117	3.54E-29
THYM	Cell metabolism gene	MRPS12	GSTP1	0.808638601	2.01E-29
THYM	Cell metabolism gene	MRPS12	ECHS1	0.80966976	1.51E-29
THYM	Cell metabolism gene	MRPS12	OAZ1	0.80983822	1.44E-29
THYM	Cell metabolism gene	MRPS12	PMM2	0.810866293	1.07E-29
THYM	Cell metabolism gene	MRPS12	MDH2	0.812516516	6.68E-30
THYM	Cell metabolism gene	MRPS12	PSMC3	0.813600447	4.88E-30
THYM	Cell metabolism gene	MRPS12	PPCDC	0.814032129	4.31E-30
THYM	Cell metabolism gene	MRPS12	GRPEL1	0.814049555	4.28E-30
THYM	Cell metabolism gene	MRPS12	TOMM5	0.814108425	4.21E-30
THYM	Cell metabolism gene	MRPS12	SNRPB	0.815717006	2.63E-30
THYM	Cell metabolism gene	MRPS12	DPM3	0.81649453	2.09E-30
THYM	Cell metabolism gene	MRPS12	SLC27A5	0.819735292	7.96E-31
THYM	Cell metabolism gene	MRPS12	PAFAH1B3	0.82246222	3.48E-31
THYM	Cell metabolism gene	MRPS12	IDH3B	0.823401329	2.61E-31
THYM	Cell metabolism gene	MRPS12	NIT2	0.823691013	2.39E-31
THYM	Cell metabolism gene	MRPS12	PHKG2	0.825387237	1.41E-31
THYM	Cell metabolism gene	MRPS12	CCT7	0.827012019	8.47E-32
THYM	Cell metabolism gene	MRPS12	PSMB2	0.827440348	7.40E-32
THYM	Cell metabolism gene	MRPS12	MED27	0.828351009	5.54E-32
THYM	Cell metabolism gene	MRPS12	LSM4	0.829210571	4.21E-32
THYM	Cell metabolism gene	MRPS12	POLD2	0.830582775	2.71E-32
THYM	Cell metabolism gene	MRPS12	PSMC1	0.832358464	1.52E-32
THYM	Cell metabolism gene	MRPS12	UROS	0.832887692	1.28E-32
THYM	Cell metabolism gene	MRPS12	TOMM22	0.833545632	1.03E-32
THYM	Cell metabolism gene	MRPS12	GSTZ1	0.83450325	7.53E-33
THYM	Cell metabolism gene	MRPS12	CCT3	0.841633855	6.71E-34
THYM	Cell metabolism gene	MRPS12	NOP56	0.842219685	5.47E-34
THYM	Cell metabolism gene	MRPS12	POLE4	0.843006343	4.16E-34
THYM	Cell metabolism gene	MRPS12	PSMC5	0.843726553	3.23E-34
THYM	Cell metabolism gene	MRPS12	FDPS	0.846178201	1.35E-34
THYM	Cell metabolism gene	MRPS12	ATIC	0.846239303	1.32E-34
THYM	Cell metabolism gene	MRPS12	APRT	0.847720706	7.73E-35
THYM	Cell metabolism gene	MRPS12	PGP	0.847743606	7.67E-35
THYM	Cell metabolism gene	MRPS12	PSMA7	0.849788857	3.63E-35
THYM	Cell metabolism gene	MRPS12	DTYMK	0.852233388	1.47E-35
THYM	Cell metabolism gene	MRPS12	SRM	0.852704529	1.23E-35
THYM	Cell metabolism gene	MRPS12	PSMB7	0.853443047	9.29E-36
THYM	Cell metabolism gene	MRPS12	MIF	0.854454218	6.33E-36
THYM	Cell metabolism gene	MRPS12	GUK1	0.854916516	5.31E-36
THYM	Cell metabolism gene	MRPS12	GMPPA	0.855302723	4.58E-36
THYM	Cell metabolism gene	MRPS12	PGLS	0.855730395	3.88E-36
THYM	Cell metabolism gene	MRPS12	PSMD8	0.858645827	1.25E-36
THYM	Cell metabolism gene	MRPS12	TIMM8B	0.859953131	7.45E-37
THYM	Cell metabolism gene	MRPS12	SNRPE	0.862195792	3.03E-37
THYM	Cell metabolism gene	MRPS12	PTGES2	0.86265649	2.52E-37
THYM	Cell metabolism gene	MRPS12	ALG3	0.863888428	1.52E-37
THYM	Cell metabolism gene	MRPS12	WBSCR22	0.864045616	1.43E-37
THYM	Cell metabolism gene	MRPS12	PSME2	0.86545755	7.97E-38
THYM	Cell metabolism gene	MRPS12	ITPA	0.867561169	3.31E-38
THYM	Cell metabolism gene	MRPS12	GEMIN6	0.871722432	5.54E-39
THYM	Cell metabolism gene	MRPS12	HSD17B10	0.872517605	3.91E-39
THYM	Cell metabolism gene	MRPS12	SNRPD2	0.87293188	3.26E-39
THYM	Cell metabolism gene	MRPS12	TBCB	0.874893719	1.36E-39
THYM	Cell metabolism gene	MRPS12	ACOT8	0.87490405	1.35E-39
THYM	Cell metabolism gene	MRPS12	PSMC4	0.878539272	2.58E-40
THYM	Cell metabolism gene	MRPS12	TPI1	0.878608297	2.50E-40
THYM	Cell metabolism gene	MRPS12	TIMM10	0.88090868	8.52E-41
THYM	Cell metabolism gene	MRPS12	TSTA3	0.881440233	6.62E-41
THYM	Cell metabolism gene	MRPS12	HMBS	0.88188018	5.37E-41
THYM	Cell metabolism gene	MRPS12	PYCRL	0.882844413	3.38E-41
THYM	Cell metabolism gene	MRPS12	EBP	0.884725657	1.36E-41
THYM	Cell metabolism gene	MRPS12	POLR2I	0.884901958	1.24E-41
THYM	Cell metabolism gene	MRPS12	NME2	0.88826286	2.33E-42
THYM	Cell metabolism gene	MRPS12	TIMM17B	0.889618105	1.17E-42
THYM	Cell metabolism gene	MRPS12	EXOSC5	0.890122957	9.01E-43
THYM	Cell metabolism gene	MRPS12	PMPCA	0.890879458	6.09E-43
THYM	Cell metabolism gene	MRPS12	POLR2H	0.890991707	5.75E-43
THYM	Cell metabolism gene	MRPS12	PSMB3	0.894593244	8.55E-44
THYM	Cell metabolism gene	MRPS12	PSMB4	0.895173031	6.25E-44
THYM	Cell metabolism gene	MRPS12	TIMM13	0.897687294	1.57E-44
THYM	Cell metabolism gene	MRPS12	NME1	0.900401627	3.40E-45
THYM	Cell metabolism gene	MRPS12	DOHH	0.908462063	2.75E-47
THYM	Cell metabolism gene	MRPS12	HMOX2	0.90953965	1.40E-47
THYM	Cell metabolism gene	MRPS12	MTX1	0.910593525	7.14E-48
THYM	Cell metabolism gene	MRPS12	TIMM50	0.912693582	1.83E-48
THYM	Cell metabolism gene	MRPS12	NANS	0.914588124	5.19E-49
THYM	Cell metabolism gene	MRPS12	TOMM40	0.916332859	1.59E-49
THYM	Cell metabolism gene	MRPS12	PSMD4	0.919221922	2.10E-50
THYM	Cell metabolism gene	MRPS12	CYC1	0.920107458	1.11E-50
THYM	Cell metabolism gene	MRPS12	EXOSC4	0.932787169	5.12E-55
THYM	Cell metabolism gene	MRPS12	GEMIN7	0.935196888	6.16E-56
THYM	Cell metabolism gene	MRPS12	ATP5G1	0.9403253	5.10E-58
THYM	CGC	MRPS12	TFPT	0.811196742	9.75E-30
THYM	CGC	MRPS12	KEAP1	0.823167475	2.80E-31
THYM	CGC	MRPS12	PRCC	0.827220228	7.93E-32
THYM	CGC	MRPS12	ASPSCR1	0.831938679	1.75E-32
THYM	CGC	MRPS12	SDHAF2	0.839470573	1.42E-33
THYM	CGC	MRPS12	ATIC	0.846239303	1.32E-34
THYM	CGC	MRPS12	COX6C	0.856802955	2.57E-36
THYM	Epifactor	MRPS12	TFPT	0.811196742	9.75E-30
THYM	Epifactor	MRPS12	PPP4C	0.816505442	2.09E-30
THYM	Epifactor	MRPS12	RUVBL2	0.816864142	1.88E-30
THYM	Epifactor	MRPS12	TAF10	0.818500274	1.15E-30
THYM	Epifactor	MRPS12	ZGPAT	0.820196774	6.93E-31
THYM	Epifactor	MRPS12	KEAP1	0.823167475	2.80E-31
THYM	Epifactor	MRPS12	ZNHIT1	0.829392749	3.98E-32
THYM	Epifactor	MRPS12	RRP8	0.835268556	5.84E-33
THYM	Epifactor	MRPS12	FBL	0.841878196	6.16E-34
THYM	Epifactor	MRPS12	VPS72	0.844025254	2.90E-34
THYM	Epifactor	MRPS12	SIRT6	0.855155015	4.84E-36
THYM	Epifactor	MRPS12	PRPF31	0.864552359	1.16E-37
THYM	Epifactor	MRPS12	PRMT1	0.864949917	9.84E-38
THYM	Epifactor	MRPS12	BRMS1	0.867293187	3.70E-38
THYM	Epifactor	MRPS12	LAS1L	0.867435758	3.49E-38
THYM	Epifactor	MRPS12	EXOSC5	0.890122957	9.01E-43
THYM	Epifactor	MRPS12	CDK5	0.899159452	6.90E-45
THYM	Epifactor	MRPS12	EXOSC4	0.932787169	5.12E-55
THYM	IUPHAR	MRPS12	USP5	0.801419288	1.47E-28
THYM	IUPHAR	MRPS12	MPDU1	0.805212304	5.24E-29
THYM	IUPHAR	MRPS12	EGLN2	0.806243904	3.94E-29
THYM	IUPHAR	MRPS12	PSMB6	0.806621117	3.54E-29
THYM	IUPHAR	MRPS12	SLC27A5	0.819735292	7.96E-31
THYM	IUPHAR	MRPS12	KEAP1	0.823167475	2.80E-31
THYM	IUPHAR	MRPS12	PHKG2	0.825387237	1.41E-31
THYM	IUPHAR	MRPS12	ABCB8	0.827148749	8.11E-32
THYM	IUPHAR	MRPS12	PSMB2	0.827440348	7.40E-32
THYM	IUPHAR	MRPS12	FKBP1A	0.84052281	9.86E-34
THYM	IUPHAR	MRPS12	SLC39A3	0.844945656	2.10E-34
THYM	IUPHAR	MRPS12	FDPS	0.846178201	1.35E-34
THYM	IUPHAR	MRPS12	ATP6V0B	0.85145486	1.96E-35
THYM	IUPHAR	MRPS12	SIRT6	0.855155015	4.84E-36
THYM	IUPHAR	MRPS12	PTGES2	0.86265649	2.52E-37
THYM	IUPHAR	MRPS12	PRMT1	0.864949917	9.84E-38
THYM	IUPHAR	MRPS12	ECE2	0.866769814	4.61E-38
THYM	IUPHAR	MRPS12	CDK5	0.899159452	6.90E-45
THYM	IUPHAR	MRPS12	HMOX2	0.90953965	1.40E-47
THYM	Kinase	MRPS12	FASTK	0.821997723	4.01E-31
THYM	Kinase	MRPS12	PHKG2	0.825387237	1.41E-31
THYM	Kinase	MRPS12	ADCK4	0.859356772	9.44E-37
THYM	Kinase	MRPS12	CDK5	0.899159452	6.90E-45
THYM	TF	MRPS12	IRF3	0.804022029	7.26E-29
THYM	TF	MRPS12	ZNF672	0.80617906	4.01E-29
THYM	TF	MRPS12	ZGPAT	0.820196774	6.93E-31
THYM	TF	MRPS12	ZNF668	0.822554689	3.38E-31
THYM	TF	MRPS12	GLI4	0.826049173	1.15E-31
THYM	TF	MRPS12	ZNF787	0.857125285	2.26E-36
THYM	TF	MRPS12	ZNF688	0.857324021	2.10E-36
THYM	TF	MRPS12	USF1	0.861319177	4.32E-37
THYM	TF	MRPS12	NME2	0.88826286	2.33E-42
THYM	TF	MRPS12	ZNF581	0.893330426	1.68E-43
THYM	TSG	MRPS12	IRF3	0.804022029	7.26E-29
THYM	TSG	MRPS12	GSTP1	0.808638601	2.01E-29
THYM	TSG	MRPS12	RTN4IP1	0.81561524	2.71E-30
THYM	TSG	MRPS12	ZNF668	0.822554689	3.38E-31
THYM	TSG	MRPS12	NIT2	0.823691013	2.39E-31
THYM	TSG	MRPS12	TSSC4	0.835959469	4.64E-33
THYM	TSG	MRPS12	PINX1	0.845245227	1.88E-34
THYM	TSG	MRPS12	PHB	0.846178203	1.35E-34
THYM	TSG	MRPS12	SIRT6	0.855155015	4.84E-36
THYM	TSG	MRPS12	GADD45GIP1	0.865987032	6.40E-38
THYM	TSG	MRPS12	BRMS1	0.867293187	3.70E-38
THYM	TSG	MRPS12	STUB1	0.899007444	7.51E-45
THYM	TSG	MRPS12	NME1	0.900401627	3.40E-45
UCEC	Cell metabolism gene	MRPS12	TOMM40	0.806158248	3.11E-47
UCEC	Cell metabolism gene	MRPS12	TIMM50	0.827856843	7.37E-52
UCEC	Cell metabolism gene	MRPS12	GEMIN7	0.830959873	1.42E-52
UCEC	Cell metabolism gene	MRPS12	PSMD8	0.866336747	6.54E-62
UCS	Cell metabolism gene	MRPS12	SEC61G	0.801328519	1.51E-28
UCS	Cell metabolism gene	MRPS12	PSME1	0.804080236	7.15E-29
UCS	Cell metabolism gene	MRPS12	PSMB6	0.806621117	3.54E-29
UCS	Cell metabolism gene	MRPS12	GSTP1	0.808638601	2.01E-29
UCS	Cell metabolism gene	MRPS12	ECHS1	0.80966976	1.51E-29
UCS	Cell metabolism gene	MRPS12	OAZ1	0.80983822	1.44E-29
UCS	Cell metabolism gene	MRPS12	PMM2	0.810866293	1.07E-29
UCS	Cell metabolism gene	MRPS12	MDH2	0.812516516	6.68E-30
UCS	Cell metabolism gene	MRPS12	PSMC3	0.813600447	4.88E-30
UCS	Cell metabolism gene	MRPS12	PPCDC	0.814032129	4.31E-30
UCS	Cell metabolism gene	MRPS12	GRPEL1	0.814049555	4.28E-30
UCS	Cell metabolism gene	MRPS12	TOMM5	0.814108425	4.21E-30
UCS	Cell metabolism gene	MRPS12	SNRPB	0.815717006	2.63E-30
UCS	Cell metabolism gene	MRPS12	DPM3	0.81649453	2.09E-30
UCS	Cell metabolism gene	MRPS12	SLC27A5	0.819735292	7.96E-31
UCS	Cell metabolism gene	MRPS12	PAFAH1B3	0.82246222	3.48E-31
UCS	Cell metabolism gene	MRPS12	IDH3B	0.823401329	2.61E-31
UCS	Cell metabolism gene	MRPS12	NIT2	0.823691013	2.39E-31
UCS	Cell metabolism gene	MRPS12	PHKG2	0.825387237	1.41E-31
UCS	Cell metabolism gene	MRPS12	CCT7	0.827012019	8.47E-32
UCS	Cell metabolism gene	MRPS12	PSMB2	0.827440348	7.40E-32
UCS	Cell metabolism gene	MRPS12	MED27	0.828351009	5.54E-32
UCS	Cell metabolism gene	MRPS12	LSM4	0.829210571	4.21E-32
UCS	Cell metabolism gene	MRPS12	POLD2	0.830582775	2.71E-32
UCS	Cell metabolism gene	MRPS12	PSMC1	0.832358464	1.52E-32
UCS	Cell metabolism gene	MRPS12	UROS	0.832887692	1.28E-32
UCS	Cell metabolism gene	MRPS12	TOMM22	0.833545632	1.03E-32
UCS	Cell metabolism gene	MRPS12	GSTZ1	0.83450325	7.53E-33
UCS	Cell metabolism gene	MRPS12	CCT3	0.841633855	6.71E-34
UCS	Cell metabolism gene	MRPS12	NOP56	0.842219685	5.47E-34
UCS	Cell metabolism gene	MRPS12	POLE4	0.843006343	4.16E-34
UCS	Cell metabolism gene	MRPS12	PSMC5	0.843726553	3.23E-34
UCS	Cell metabolism gene	MRPS12	FDPS	0.846178201	1.35E-34
UCS	Cell metabolism gene	MRPS12	ATIC	0.846239303	1.32E-34
UCS	Cell metabolism gene	MRPS12	APRT	0.847720706	7.73E-35
UCS	Cell metabolism gene	MRPS12	PGP	0.847743606	7.67E-35
UCS	Cell metabolism gene	MRPS12	PSMA7	0.849788857	3.63E-35
UCS	Cell metabolism gene	MRPS12	DTYMK	0.852233388	1.47E-35
UCS	Cell metabolism gene	MRPS12	SRM	0.852704529	1.23E-35
UCS	Cell metabolism gene	MRPS12	PSMB7	0.853443047	9.29E-36
UCS	Cell metabolism gene	MRPS12	MIF	0.854454218	6.33E-36
UCS	Cell metabolism gene	MRPS12	GUK1	0.854916516	5.31E-36
UCS	Cell metabolism gene	MRPS12	GMPPA	0.855302723	4.58E-36
UCS	Cell metabolism gene	MRPS12	PGLS	0.855730395	3.88E-36
UCS	Cell metabolism gene	MRPS12	PSMD8	0.858645827	1.25E-36
UCS	Cell metabolism gene	MRPS12	TIMM8B	0.859953131	7.45E-37
UCS	Cell metabolism gene	MRPS12	SNRPE	0.862195792	3.03E-37
UCS	Cell metabolism gene	MRPS12	PTGES2	0.86265649	2.52E-37
UCS	Cell metabolism gene	MRPS12	ALG3	0.863888428	1.52E-37
UCS	Cell metabolism gene	MRPS12	WBSCR22	0.864045616	1.43E-37
UCS	Cell metabolism gene	MRPS12	PSME2	0.86545755	7.97E-38
UCS	Cell metabolism gene	MRPS12	ITPA	0.867561169	3.31E-38
UCS	Cell metabolism gene	MRPS12	GEMIN6	0.871722432	5.54E-39
UCS	Cell metabolism gene	MRPS12	HSD17B10	0.872517605	3.91E-39
UCS	Cell metabolism gene	MRPS12	SNRPD2	0.87293188	3.26E-39
UCS	Cell metabolism gene	MRPS12	TBCB	0.874893719	1.36E-39
UCS	Cell metabolism gene	MRPS12	ACOT8	0.87490405	1.35E-39
UCS	Cell metabolism gene	MRPS12	PSMC4	0.878539272	2.58E-40
UCS	Cell metabolism gene	MRPS12	TPI1	0.878608297	2.50E-40
UCS	Cell metabolism gene	MRPS12	TIMM10	0.88090868	8.52E-41
UCS	Cell metabolism gene	MRPS12	TSTA3	0.881440233	6.62E-41
UCS	Cell metabolism gene	MRPS12	HMBS	0.88188018	5.37E-41
UCS	Cell metabolism gene	MRPS12	PYCRL	0.882844413	3.38E-41
UCS	Cell metabolism gene	MRPS12	EBP	0.884725657	1.36E-41
UCS	Cell metabolism gene	MRPS12	POLR2I	0.884901958	1.24E-41
UCS	Cell metabolism gene	MRPS12	NME2	0.88826286	2.33E-42
UCS	Cell metabolism gene	MRPS12	TIMM17B	0.889618105	1.17E-42
UCS	Cell metabolism gene	MRPS12	EXOSC5	0.890122957	9.01E-43
UCS	Cell metabolism gene	MRPS12	PMPCA	0.890879458	6.09E-43
UCS	Cell metabolism gene	MRPS12	POLR2H	0.890991707	5.75E-43
UCS	Cell metabolism gene	MRPS12	PSMB3	0.894593244	8.55E-44
UCS	Cell metabolism gene	MRPS12	PSMB4	0.895173031	6.25E-44
UCS	Cell metabolism gene	MRPS12	TIMM13	0.897687294	1.57E-44
UCS	Cell metabolism gene	MRPS12	NME1	0.900401627	3.40E-45
UCS	Cell metabolism gene	MRPS12	DOHH	0.908462063	2.75E-47
UCS	Cell metabolism gene	MRPS12	HMOX2	0.90953965	1.40E-47
UCS	Cell metabolism gene	MRPS12	MTX1	0.910593525	7.14E-48
UCS	Cell metabolism gene	MRPS12	TIMM50	0.912693582	1.83E-48
UCS	Cell metabolism gene	MRPS12	NANS	0.914588124	5.19E-49
UCS	Cell metabolism gene	MRPS12	TOMM40	0.916332859	1.59E-49
UCS	Cell metabolism gene	MRPS12	PSMD4	0.919221922	2.10E-50
UCS	Cell metabolism gene	MRPS12	CYC1	0.920107458	1.11E-50
UCS	Cell metabolism gene	MRPS12	EXOSC4	0.932787169	5.12E-55
UCS	Cell metabolism gene	MRPS12	GEMIN7	0.935196888	6.16E-56
UCS	Cell metabolism gene	MRPS12	ATP5G1	0.9403253	5.10E-58
UCS	CGC	MRPS12	TFPT	0.811196742	9.75E-30
UCS	CGC	MRPS12	KEAP1	0.823167475	2.80E-31
UCS	CGC	MRPS12	PRCC	0.827220228	7.93E-32
UCS	CGC	MRPS12	ASPSCR1	0.831938679	1.75E-32
UCS	CGC	MRPS12	SDHAF2	0.839470573	1.42E-33
UCS	CGC	MRPS12	ATIC	0.846239303	1.32E-34
UCS	CGC	MRPS12	COX6C	0.856802955	2.57E-36
UCS	Epifactor	MRPS12	TFPT	0.811196742	9.75E-30
UCS	Epifactor	MRPS12	PPP4C	0.816505442	2.09E-30
UCS	Epifactor	MRPS12	RUVBL2	0.816864142	1.88E-30
UCS	Epifactor	MRPS12	TAF10	0.818500274	1.15E-30
UCS	Epifactor	MRPS12	ZGPAT	0.820196774	6.93E-31
UCS	Epifactor	MRPS12	KEAP1	0.823167475	2.80E-31
UCS	Epifactor	MRPS12	ZNHIT1	0.829392749	3.98E-32
UCS	Epifactor	MRPS12	RRP8	0.835268556	5.84E-33
UCS	Epifactor	MRPS12	FBL	0.841878196	6.16E-34
UCS	Epifactor	MRPS12	VPS72	0.844025254	2.90E-34
UCS	Epifactor	MRPS12	SIRT6	0.855155015	4.84E-36
UCS	Epifactor	MRPS12	PRPF31	0.864552359	1.16E-37
UCS	Epifactor	MRPS12	PRMT1	0.864949917	9.84E-38
UCS	Epifactor	MRPS12	BRMS1	0.867293187	3.70E-38
UCS	Epifactor	MRPS12	LAS1L	0.867435758	3.49E-38
UCS	Epifactor	MRPS12	EXOSC5	0.890122957	9.01E-43
UCS	Epifactor	MRPS12	CDK5	0.899159452	6.90E-45
UCS	Epifactor	MRPS12	EXOSC4	0.932787169	5.12E-55
UCS	IUPHAR	MRPS12	USP5	0.801419288	1.47E-28
UCS	IUPHAR	MRPS12	MPDU1	0.805212304	5.24E-29
UCS	IUPHAR	MRPS12	EGLN2	0.806243904	3.94E-29
UCS	IUPHAR	MRPS12	PSMB6	0.806621117	3.54E-29
UCS	IUPHAR	MRPS12	SLC27A5	0.819735292	7.96E-31
UCS	IUPHAR	MRPS12	KEAP1	0.823167475	2.80E-31
UCS	IUPHAR	MRPS12	PHKG2	0.825387237	1.41E-31
UCS	IUPHAR	MRPS12	ABCB8	0.827148749	8.11E-32
UCS	IUPHAR	MRPS12	PSMB2	0.827440348	7.40E-32
UCS	IUPHAR	MRPS12	FKBP1A	0.84052281	9.86E-34
UCS	IUPHAR	MRPS12	SLC39A3	0.844945656	2.10E-34
UCS	IUPHAR	MRPS12	FDPS	0.846178201	1.35E-34
UCS	IUPHAR	MRPS12	ATP6V0B	0.85145486	1.96E-35
UCS	IUPHAR	MRPS12	SIRT6	0.855155015	4.84E-36
UCS	IUPHAR	MRPS12	PTGES2	0.86265649	2.52E-37
UCS	IUPHAR	MRPS12	PRMT1	0.864949917	9.84E-38
UCS	IUPHAR	MRPS12	ECE2	0.866769814	4.61E-38
UCS	IUPHAR	MRPS12	CDK5	0.899159452	6.90E-45
UCS	IUPHAR	MRPS12	HMOX2	0.90953965	1.40E-47
UCS	Kinase	MRPS12	FASTK	0.821997723	4.01E-31
UCS	Kinase	MRPS12	PHKG2	0.825387237	1.41E-31
UCS	Kinase	MRPS12	ADCK4	0.859356772	9.44E-37
UCS	Kinase	MRPS12	CDK5	0.899159452	6.90E-45
UCS	TF	MRPS12	IRF3	0.804022029	7.26E-29
UCS	TF	MRPS12	ZNF672	0.80617906	4.01E-29
UCS	TF	MRPS12	ZGPAT	0.820196774	6.93E-31
UCS	TF	MRPS12	ZNF668	0.822554689	3.38E-31
UCS	TF	MRPS12	GLI4	0.826049173	1.15E-31
UCS	TF	MRPS12	ZNF787	0.857125285	2.26E-36
UCS	TF	MRPS12	ZNF688	0.857324021	2.10E-36
UCS	TF	MRPS12	USF1	0.861319177	4.32E-37
UCS	TF	MRPS12	NME2	0.88826286	2.33E-42
UCS	TF	MRPS12	ZNF581	0.893330426	1.68E-43
UCS	TSG	MRPS12	IRF3	0.804022029	7.26E-29
UCS	TSG	MRPS12	GSTP1	0.808638601	2.01E-29
UCS	TSG	MRPS12	RTN4IP1	0.81561524	2.71E-30
UCS	TSG	MRPS12	ZNF668	0.822554689	3.38E-31
UCS	TSG	MRPS12	NIT2	0.823691013	2.39E-31
UCS	TSG	MRPS12	TSSC4	0.835959469	4.64E-33
UCS	TSG	MRPS12	PINX1	0.845245227	1.88E-34
UCS	TSG	MRPS12	PHB	0.846178203	1.35E-34
UCS	TSG	MRPS12	SIRT6	0.855155015	4.84E-36
UCS	TSG	MRPS12	GADD45GIP1	0.865987032	6.40E-38
UCS	TSG	MRPS12	BRMS1	0.867293187	3.70E-38
UCS	TSG	MRPS12	STUB1	0.899007444	7.51E-45
UCS	TSG	MRPS12	NME1	0.900401627	3.40E-45
UVM	Cell metabolism gene	MRPS12	TIMM50	0.809809114	9.54E-20
UVM	Cell metabolism gene	MRPS12	FLAD1	0.810309032	8.69E-20
UVM	Cell metabolism gene	MRPS12	PSMC4	0.822800947	7.86E-21
UVM	Cell metabolism gene	MRPS12	TOMM40	0.825426679	4.63E-21
UVM	Cell metabolism gene	MRPS12	PSMD8	0.849531327	2.29E-23
UVM	Cell metabolism gene	MRPS12	TIMM13	0.854404865	6.98E-24
UVM	Cell metabolism gene	MRPS12	SCO2	0.88076305	4.87E-27
UVM	Epifactor	MRPS12	RUVBL2	0.805432478	2.12E-19
UVM	IUPHAR	MRPS12	SLC39A3	0.851187891	1.53E-23
UVM	Kinase	MRPS12	ADCK4	0.839034487	2.57E-22
UVM	TSG	MRPS12	PFN1	0.80337658	3.06E-19

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
BRCA	MRPS12	MRPS15	-2.19567551682318	0.000188684660674703
KICH	MRPS12	MRPS5	1.25108287838437	0.000249803066253662
LIHC	MRPS12	MRPS7	1.27029395477208	0.00182077236082954
STAD	MRPS12	MRPS16	-1.64208084987431	0.00239070039242506
KIRC	MRPS12	MRPS15	1.11572283836012	0.00361818577801855
PRAD	MRPS12	MRPS9	1.04379115553269	0.00496210155254694
HNSC	MRPS12	MRPS16	-2.01564621821803	0.00518989327406416
CHOL	MRPS12	MRPS6	2.57097392409939	0.0078125
KICH	MRPS12	MRPS2	1.26543989555015	0.0114533305168152
LUSC	MRPS12	MRPS6	-1.26158810839259	0.013873001943322
THCA	MRPS12	MRPS15	-1.19960602422995	0.0140154883942907
ESCA	MRPS12	MRPS5	-2.15440118747854	0.0185546875
ESCA	MRPS12	MRPS2	-3.20556788084675	0.0244140625
THCA	MRPS12	MRPS11	-3.10694728540962	0.0252226935182201
BLCA	MRPS12	MRPS11	-2.30276998968219	0.040130615234375
THCA	MRPS12	MRPS10	1.33413691764991	1.55171507174296e-05
LUAD	MRPS12	MRPS5	-2.20881945885927	1.77904381378076e-06
LUSC	MRPS12	MRPS9	-3.60637641031661	1.82498668910368e-07
LUSC	MRPS12	MRPS2	-2.70930846488508	1.92864354932136e-09
LUAD	MRPS12	MRPS9	-1.32894454884901	1.98978698949574e-05
BRCA	MRPS12	MRPS11	-1.24304977976804	2.31302509538916e-07
PRAD	MRPS12	MRPS6	1.00673230965164	3.48152859299693e-07
LUAD	MRPS12	MRPS14	-3.02634914022647	4.24616078981701e-06
LIHC	MRPS12	MRPS2	-1.14771055358828	4.2584580238307e-05
LUSC	MRPS12	MRPS5	-7.65956389962319	4.27210217182982e-06
KIRC	MRPS12	MRPS6	-3.12621933743663	4.95376546353503e-10
LUSC	MRPS12	MRPS11	-2.9004097541444	5.43966600483641e-07
LUSC	MRPS12	MRPS14	-3.86726163364221	6.1453992201761e-05
KICH	MRPS12	MRPS6	-1.34376231922276	7.49826431274414e-05
BRCA	MRPS12	MRPS7	-2.12787460270434	9.33194208595055e-10

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MRPS12

SPINK7, C14orf1, CRMP1, UNC119, LRIF1, RPS3, CNOT2, CKAP5, MPHOSPH8, ZSCAN5A, USP43, Dctn1, Nfyc, Cdc23, Kif2c, DKK3, RNF31, TUBA1A, TGOLN2, CDK7, EEA1, FBL, TP63, MAD2L2, NR2C2, SNRNP70, PLEKHA4, FYN, ACAD9, ACAT1, ACOT1, ACOT2, AFG3L2, ATPIF1, ATP5J2-PTCD1, ATP5F1, ATP5J, ATPAF1, BCS1L, C17orf80, C1QBP, CARS2, CDK5RAP1, CLPP, CLPX, CS, DAP3, DDX28, DDX50, DDX54, DHX30, DHX57, DLAT, DLST, DNAJC11, ECHS1, ELAC2, ERAL1, ERLIN1, ERLIN2, ETFA, ETFB, FASTKD2, GADD45GIP1, GFM1, GLS, GRSF1, GTPBP10, GTPBP6, GUF1, HADHA, HINT2, HNRNPA3, HNRNPAB, HNRNPDL, HNRNPL, HNRNPUL1, IARS2, KIAA0391, LARS2, LETM1, LRPPRC, MDH2, MGME1, MMAB, RNMTL1, MRPL1, MRPL10, MRPL12, MRPL13, MRPL15, MRPL17, MRPL18, MRPL19, MRPL2, MRPL20, MRPL21, MRPL22, MRPL23, MRPL24, MRPL27, MRPL28, MRPL3, MRPL30, MRPL37, MRPL38, MRPL39, MRPL4, MRPL40, MRPL41, MRPL42, MRPL43, MRPL44, MRPL45, MRPL46, MRPL47, MRPL48, MRPL49, MRPL50, MRPL52, MRPL53, MRPL55, ICT1, MRPL9, MRPS10, MRPS14, MRPS16, MRPS17, MRPS18A, MRPS18B, MRPS18C, MRPS2, MRPS22, MRPS23, MRPS24, MRPS25, MRPS26, MRPS27, MRPS28, MRPS30, MRPS31, MRPS33, MRPS34, MRPS35, MRPS36, MRPS5, MRPS6, MRPS7, MRPS9, MTERF3, MTIF2, MTPAP, NDUFA12, NDUFA2, NDUFA5, NDUFA6, NDUFA7, NDUFA9, NDUFAF1, NDUFAF3, NDUFAF4, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, NFS1, NIPSNAP1, NME4, NOA1, NUDT19, OGDH, PDHA1, PDHB, PNPT1, POLDIP2, POLRMT, PPIF, PREPL, PTCD3, PYCR1, PYCR2, RBMX, WBSCR16, RPUSD4, RTN4IP1, SHMT2, SLC2A1, SLC30A9, SLIRP, STOML2, SUPV3L1, TACO1, TARS2, TEFM, TIMM44, TRMT10C, TRUB2, C10orf2, UBR4, VARS2, VWA8, ACACA, INS, E7, UFL1, DDRGK1, ZBTB2, NOTCH2, METAP1, CBWD1, PRG2, TUBB, RPL10, ABT1, MRPS15, NRP1, TOP3B, ETV4, NFATC4, SOX17, SOX4, TLX3, KLF5, SOX2, SOX5, TLX2,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MRPS12	LIHC	chr19	39421984	39421984	G	A	Splice_Site		5
MRPS12	ESCA	chr19	39422990	39422990	C	T	Missense_Mutation	p.R23W	3
MRPS12	GBM	chr19	39423173	39423173	C	T	Missense_Mutation	p.R84W	3
MRPS12	UCEC	chr19	39423117	39423117	C	T	Missense_Mutation	p.T65M	3
MRPS12	BLCA	chr19	39422995	39422995	C	G	Silent	p.L24L	2
MRPS12	STAD	chr19	39423241	39423241	G	C	Missense_Mutation	p.Q106H	2
MRPS12	UCEC	chr19	39423284	39423284	G	A	Missense_Mutation	p.V121I	2
MRPS12	LUAD	chr19	39423302	39423302	C	T	Missense_Mutation	p.R127C	1
MRPS12	COAD	chr19	39423189	39423189	G	A	Missense_Mutation	p.R89H	1
MRPS12	READ	chr19	39423124	39423124	C	A	Silent	p.T67T	1
MRPS12	COAD	chr19	39423263	39423263	C	T	Missense_Mutation	p.R114C	1
MRPS12	SARC	chr19	39423186	39423186	G	T	Missense_Mutation		1
MRPS12	DLBC	chr19	39421979	39421979	T	G	Silent	p.T15T	1
MRPS12	SARC	chr19	39421417	39421417	C	T	Missense_Mutation		1
MRPS12	ESCA	chr19	39422990	39422990	C	T	Missense_Mutation		1
MRPS12	THYM	chr19	39423334	39423334	G	T	Missense_Mutation	p.K137N	1
MRPS12	KICH	chr19	39423173	39423174	-	-	Frame_Shift_Ins		1
MRPS12	UCEC	chr19	39423040	39423040	G	-	Frame_Shift_Del	p.L39fs	1
MRPS12	KICH	chr19	39421914	39421914	A	G	Splice_Site		1
MRPS12	BLCA	chr19	39421891	39421891	C	G	Missense_Mutation		1
MRPS12	BLCA	chr19	39422995	39422995	C	G	Silent		1
MRPS12	LUAD	chr19	39423062	39423062	C	T	Missense_Mutation	p.R47W	1

Copy number variation (CNV) of MRPS12
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MRPS12
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
101183	N/A	AI446790	MRPS12	chr19	39423570	-	RBM33	chr7	155571078	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	MRPS12	0.0338836259427663	0.95
KIRC	MRPS12	0.0377447311696046	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
THCA	MRPS12	0.00159840828609533	0.051
KIRC	MRPS12	0.039445145018798	1
UCEC	MRPS12	0.00555259301885478	0.17
THYM	MRPS12	0.0434672626229544	1
SARC	MRPS12	0.00117225697241164	0.039
CHOL	MRPS12	0.0255086207691769	0.77

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source