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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPS4X (NCBI Gene ID:6191)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPS4X
	Gene ID: 6191
	Gene Symbol	RPS4X
	Gene ID	6191
	Gene Name	ribosomal protein S4 X-linked
	Synonyms	CCG2\|DXS306\|RPS4\|S4\|SCAR\|SCR10
	Cytomap	Xq13.1
	Type of Gene	protein-coding
	Description	40S ribosomal protein S4, X isoformcell cycle gene 2ribosomal protein S4X isoformsingle copy abundant mRNA proteinsingle-copy abundant mRNAsmall ribosomal subunit protein eS4
	Modification date	20200313
	UniProtAcc	P62701

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0005840	Ribosome
GO:0045727	Positive regulation of translation
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPS4X	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPS4X[title] AND translation [title] AND human.'

Gene	Title	PMID
RPS4X	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000316084	71493081	71493239	Frame-shift
ENST00000316084	71493650	71493822	Frame-shift
ENST00000316084	71496006	71496084	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000316084	71496006	71496084	1543	109	186	263	1	27

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P62701	1	27	1	1	Initiator methionine	Note=Removed;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:8706699;Dbxref=PMID:8706699
P62701	1	27	2	263	Chain	ID=PRO_0000130805;Note=40S ribosomal protein S4%2C X isoform

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUAD	RPS4X	-2.43594282676366	0.0163893452361939
KIRC	RPS4X	-1.64140073680063	1.72010286166321e-07
BRCA	RPS4X	-1.55343710903986	3.36588066248297e-09
THCA	RPS4X	1.49777877118816	6.68348444344278e-07

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
SKCM	RPS4X	-0.025141879	0.007772092
LUSC	RPS4X	-0.068433664	0.023329945
STAD	RPS4X	-0.028006493	0.030376677
KIRP	RPS4X	0.015549016	0.03411982
BLCA	RPS4X	0.026194235	0.046118114

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPS4X (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	RPS4X	SLC25A6	0.810818353	1.47E-11
CHOL	IUPHAR	RPS4X	SLC25A6	0.810818353	1.47E-11
DLBC	TSG	RPS4X	GNB2L1	0.825812853	5.06E-13
LGG	Cell metabolism gene	RPS4X	FAU	0.80305869	8.45E-121
LGG	CGC	RPS4X	NACA	0.867528472	2.86E-162
LGG	TSG	RPS4X	GAS5	0.816813713	3.09E-128
LGG	TSG	RPS4X	GNB2L1	0.853444526	1.51E-151
MESO	TSG	RPS4X	GNB2L1	0.813047748	1.13E-21
PRAD	Cell metabolism gene	RPS4X	FAU	0.821314474	1.08E-135
PRAD	CGC	RPS4X	NACA	0.865337421	1.57E-166
PRAD	Epifactor	RPS4X	FBL	0.872616208	1.11E-172
PRAD	TSG	RPS4X	GAS5	0.802258132	7.12E-125
PRAD	TSG	RPS4X	GNB2L1	0.894764483	5.05E-194
UVM	Cell metabolism gene	RPS4X	FAU	0.808164338	1.29E-19
UVM	CGC	RPS4X	NACA	0.816135666	2.90E-20
UVM	Epifactor	RPS4X	FBL	0.839761008	2.19E-22
UVM	TSG	RPS4X	GLTSCR2	0.802532029	3.56E-19
UVM	TSG	RPS4X	GNB2L1	0.824398887	5.70E-21

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPS4X	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPS4X	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPS4X	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPS4X	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPS4X	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPS4X	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPS4X	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPS4X	RPL19	1.36901182894089	0.00250792503356934
KICH	RPS4X	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPS4X	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPS4X	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPS4X	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPS4X	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPS4X	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPS4X	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPS4X	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPS4X	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPS4X	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPS4X	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPS4X	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPS4X	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPS4X	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPS4X	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPS4X	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPS4X	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPS4X	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPS4X	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPS4X	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPS4X

HNRNPH3, MCM2, ARPC3, MEPCE, RUVBL2, CDK9, ESR1, DCC, HDAC5, NOP56, EBNA-LP, RAD21, SENP3, ARRB2, SIRT7, CUL3, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, CAND1, NEDD8, RPS7, RPS8, RPS15, RPS16, RPS17, RPS19, RPS20, RPS5, RPS6, RPS9, RPS11, RPS12, RPS13, RPS18, RPS2, RPS3, RPS10, RPS21, RPS14, RPL5, RPL7, RPS3A, RPSA, RPLP0, RPL10A, RPL10, RPL11, RPL12, RPL13, RPL14, RPL15, RPL18A, RPL18, RPL19, RPL21, RPL23A, RPL24, RPL27A, RPL31, RPL37A, RPL3, RPL6, RPL7A, RPL8, RPL9, RPS15A, RPS23, RPS24, RPS26, RPS28, RPS25, RPL4, RPL27, RPL30, RPL23, RPLP2, RPLP1, RPL22, RPL36, EEF2, RPL17, RPL32, RPS27A, EEF1A1, SLC25A5, FBL, NOP58, ILF2, SRP14, NPM1, GNL3, NCL, ILF3, HNRNPU, PABPC1, EIF3C, NOLC1, NHP2L1, EIF6, HNRNPM, LUC7L2, U2AF1, ACTA2, NAP1L1, TSR1, GAR1, HSPA8, RPL10L, RPLP0P6, HIST1H2AD, RPS27L, NOP2, PTRF, CDC5L, RRS1, HIST1H2AA, RPS10P5, SMURF1, HSP90AB1, HSP90AA1, ESR2, FN1, VCAM1, NOS2, UBL4A, ITGA4, PHB, PAN2, CD81, IGSF8, ICAM1, CTBP2, CAMK2D, FBXO6, TARDBP, EIF3CL, LARP1, RPS27, RPS29, EIF3D, EIF3L, FAU, WIBG, rev, ZBTB1, STAU1, AURKA, AURKB, CDKN1A, CEP250, CEP57, CEP76, LGALS3BP, NEDD1, TUBG1, TUBGCP3, VCP, TP53, HUWE1, CUL7, OBSL1, CCDC8, EED, MAGEA10, ZZEF1, HECTD3, RPS6KB2, RPL29, RPL35, RPL35A, BRIX1, BYSL, DDX18, DDX24, DKC1, EIF2S3, KRR1, NOL6, RPL13A, RPL26, RPL38, RPL39, LOC101929876, SLC25A1, TUBB2B, UBA52, XRN1, NTRK1, PTEN, XPO1, AHSA1, EXOSC4, EXOSC1, Eif3e, Rpl35, Srp72, Rrbp1, GAN, SKI, TRIM29, NF2, SSSCA1, GGPS1, CYLD, TRIM25, YAP1, MTF1, ACO2, TMPO, WDR77, CTNNB1, API5, IGF1R, KRAS, PCBP1, PPIE, TGFB1, TRIP4, UBE2M, PRPF8, EFTUD2, AAR2, PIH1D1, RPTOR, CHD3, CHD4, LARP7, TNF, SPDL1, RIOK1, HEXIM1, SNAI1, AGR2, RECQL4, RNF144A, REST, ZFP36L2, MYC, Prkaa1, Prkab1, KRT17, METTL14, KIAA1429, EIF4B, RC3H1, RC3H2, FAF1, USP14, HIV2gp4, HIV2gp3, NR2C2, PPP1CC, PPARG, CTCF, ATXN3, VRK1, HIST1H4A, SNRNP70, ITFG1, ARAF, HMGB1, PPP1CA, BIRC3, NFX1, WWP2, BRD7, MATR3, SOX2, TRIM28, CMTR1, ARIH2, PLEKHA4, TFCP2, FANCD2, NGB, HCVgp1, BPTF, M, nsp13, nsp4, nsp6, ORF3a, ORF8, NEK4, DUX4, DUX4L9, CIT, ANLN, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, TRIM55, TRIM63, LRRC59, INS, SUMO2, NDN, Rnf183, BRD4, RBM45, UCHL1, CIC, N, Apc2, RBM39, FBP1, MKRN1, LGALS9, IFI16, USP15, RIN3, RAD51, POU2F1, OGT, BAG5, SPOP, AR, ATG5, PARK2, UFL1, DDRGK1, COIL, NUP155, PANX1, PEX3, RPN2, ATG10, ATG3, FZR1, WDR5, PAGE4, S100A2, CCL3, NOTCH2, KCTD12, NEIL1, HIST1H1E, FGFBP1, TRDN, LRRC46, RPSAP58, SRSF6, SPRTN, BTF3, FBXW7, FGD5, RCHY1, CCNF, PDE4B, USP1, PSMD9, RB1CC1, ZEB1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RPS4X	chrX	71495581	C	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPS4X	BRCA	chrX	71493102	71493102	T	G	Missense_Mutation	p.N224H	4
RPS4X	BLCA	chrX	71493768	71493768	G	A	Silent		3
RPS4X	KIRP	chrX	71493691	71493691	C	T	Missense_Mutation		3
RPS4X	LIHC	chrX	71495526	71495526	G	-	Frame_Shift_Del	p.L44fs	2
RPS4X	UCEC	chrX	71493732	71493732	C	T	Missense_Mutation	p.D151N	2
RPS4X	CESC	chrX	71493751	71493751	G	A	Silent		2
RPS4X	UCEC	chrX	71493733	71493733	G	A	Silent	p.P150	2
RPS4X	LUAD	chrX	71496038	71496038	T	C	Missense_Mutation	p.H17R	2
RPS4X	CESC	chrX	71495421	71495421	C	T	Missense_Mutation		2
RPS4X	UCEC	chrX	71495440	71495440	G	A	Silent	p.I72	2
RPS4X	CESC	chrX	71495568	71495568	G	A	Missense_Mutation	p.R30C	2
RPS4X	KIRP	chrX	71493218	71493218	C	A	Missense_Mutation		2
RPS4X	SKCM	chrX	71493688	71493688	C	T	Silent	p.E165E	2
RPS4X	BLCA	chrX	71493144	71493144	C	T	Missense_Mutation	p.V210M	2
RPS4X	LGG	chrX	71493768	71493768	G	T	Missense_Mutation	p.L139M	2
RPS4X	STAD	chrX	71495454	71495454	G	A	Missense_Mutation	p.R68W	2
RPS4X	BLCA	chrX	71494972	71494972	C	T	Silent	p.E97E	2
RPS4X	BLCA	chrX	71494974	71494974	C	G	Missense_Mutation	p.E97Q	2
RPS4X	THCA	chrX	71493125	71493125	T	A	Missense_Mutation	p.N216I	2
RPS4X	BRCA	chrX	71494957	71494957	G	C	Missense_Mutation	p.I102M	2
RPS4X	UCEC	chrX	71493124	71493124	G	A	Silent	p.N216	2
RPS4X	BLCA	chrX	71494972	71494972	C	T	Silent		1
RPS4X	GBM	chrX	71492579	71492579	C	T	Missense_Mutation	p.R245H	1
RPS4X	BLCA	chrX	71494974	71494974	C	G	Missense_Mutation		1
RPS4X	LUAD	chrX	71493198	71493198	T	C	Missense_Mutation	p.I192V	1
RPS4X	GBM	chrX	71492579	71492579	C	T	Missense_Mutation		1
RPS4X	KIRP	chrX	71497043	71497043	C	A	Missense_Mutation		1
RPS4X	BLCA	chrX	71495426	71495426	C	T	Missense_Mutation		1
RPS4X	PCPG	chrX	71492543	71492543	G	A	Missense_Mutation		1
RPS4X	BLCA	chrX	71495439	71495439	C	T	Missense_Mutation	p.D73N	1
RPS4X	CESC	chrX	71495568	71495568	G	A	Missense_Mutation		1
RPS4X	SKCM	chrX	71493728	71493728	G	A	Missense_Mutation	p.P152L	1
RPS4X	CESC	chrX	71495421	71495421	C	T	Missense_Mutation	p.D79N	1
RPS4X	CESC	chrX	71493751	71493751	G	A	Silent	p.A144	1
RPS4X	LGG	chrX	71494903	71494903	C	A	Splice_Site	p.K120_splice	1
RPS4X	COAD	chrX	71492543	71492543	G	A	Missense_Mutation	p.A257V	1
RPS4X	LGG	chrX	71494903	71494903	C	A	Missense_Mutation		1
RPS4X	BLCA	chrX	71493768	71493768	G	A	Silent	p.L139L	1
RPS4X	THYM	chrX	71493154	71493154	G	A	Silent		1
RPS4X	COAD	chrX	71492548	71492548	T	C	Silent	p.R255R	1
RPS4X	BLCA	chrX	71495439	71495439	C	T	Missense_Mutation		1
RPS4X	LIHC	chrX	71493160	71493160	A	G	Silent		1
RPS4X	BLCA	chrX	71495426	71495426	C	T	Missense_Mutation	p.R77Q	1
RPS4X	UCEC	chrX	71493124	71493124	G	A	Silent	p.N216N	1
RPS4X	COAD	chrX	71493691	71493691	C	T	Silent	p.L164L	1
RPS4X	BLCA	chrX	71493144	71493144	C	T	Missense_Mutation		1
RPS4X	LIHC	chrX	71495549	71495550	-	G	Frame_Shift_Ins	p.Q36fs	1
RPS4X	COAD	chrX	71495557	71495557	G	A	Silent	p.T33T	1

Copy number variation (CNV) of RPS4X
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPS4X
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
103274	N/A	BI495844	CLCN5	chrX	49756837	+	RPS4X	chrX	71492453	+
103274	THCA	TCGA-DJ-A13V-01A	CLU	chr8	27461808	-	RPS4X	chrX	71493239	-
103274	HNSC	TCGA-CQ-6221-01A	COL3A1	chr2	189870985	+	RPS4X	chrX	71492622	-
103274	N/A	BP429982	COPG1	chr3	128996313	+	RPS4X	chrX	71493739	-
103274	N/A	N69350	DCHS2	chr4	155295147	-	RPS4X	chrX	71492453	+
103274	N/A	AA662756	DENND4A	chr15	66077828	-	RPS4X	chrX	71492458	+
103274	LUSC	TCGA-43-3920	DIDO1	chr20	61569147	-	RPS4X	chrX	71495574	-
103274	LUSC	TCGA-43-3920-01A	DIDO1	chr20	61569148	-	RPS4X	chrX	71495574	-
103274	Non-Cancer	ERR188311	EEF1A1	chr6	74227751	-	RPS4X	chrX	71494941	-
103274	Non-Cancer	ERR188410	EEF1A1	chr6	74227755	-	RPS4X	chrX	71494945	-
103274	N/A	BP428927	EPB41L4B	chr9	112009476	+	RPS4X	chrX	71492458	+
103274	N/A	BG151410	EPHB4	chr7	100410417	-	RPS4X	chrX	71492503	-
103274	N/A	AA075606	GIT2	chr12	110423455	-	RPS4X	chrX	71495428	-
103274	STAD	TCGA-D7-A6EX-01A	HDAC8	chrX	71681854	-	RPS4X	chrX	71475904	-
103274	COAD	TCGA-AZ-4681-01A	NAIP	chr5	70281588	-	RPS4X	chrX	71492623	-
103274	N/A	BF814512	NUP210	chr3	13393247	-	RPS4X	chrX	71493824	-
103274	N/A	BI495055	PTPRD	chr9	8336626	-	RPS4X	chrX	71492453	+
77943	N/A	AI382716	RPS4X	chrX	71492507	+	ALG10B	chr12	38716327	-
91919	BRCA	TCGA-A2-A0ER-01A	RPS4X	chrX	71494903	-	CPB1	chr3	148562464	+
97992	N/A	AA886124	RPS4X	chrX	71492453	-	HIC2	chr22	21786965	+
96843	OV	TCGA-13-1408-01A	RPS4X	chrX	71492532	-	IGF2	chr11	2152009	-
95951	STAD	TCGA-CD-5803-01A	RPS4X	chrX	71494903	-	MCTP1	chr5	94134837	-
77943	N/A	AW022109	RPS4X	chrX	71492462	-	POT1	chr7	124561909	+
103274	N/A	BF326184	RPS4X	chrX	71493219	+	RPS4X	chrX	71495573	-
103274	N/A	BF446002	RPS4X	chrX	71492534	+	RPS4X	chrX	71497068	-
95908	N/A	BF340548	RPS4X	chrX	71492453	-	SAMM50	chr22	44354376	-
103284	N/A	AW020422	RPS4X	chrX	71492453	-	SLC14A2	chr18	42937231	-
82910	N/A	CD579584	RPS4X	chrX	71492453	-	SLC30A9	chr4	42039296	-
99577	N/A	AW015878	RPS4X	chrX	71492541	+	SUPT5H	chr19	39963718	-
103274	N/A	BM144729	SLC14A2	chr18	42937231	+	RPS4X	chrX	71492453	+
103274	N/A	BF812451	SPTBN1	chr2	54885078	+	RPS4X	chrX	71493180	-
103274	N/A	BI492665	ZPBP	chr7	50025236	-	RPS4X	chrX	71492453	+
103278	COAD	TCGA-AZ-4681-01A	ZSWIM4	chr19	13942623	+	RPS4X	chrX	71492585	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
BRCA	RPS4X	0.000141753206544408	0.0016
READ	RPS4X	0.000258215651555145	0.0026
CHOL	RPS4X	0.00124387912096824	0.011
SARC	RPS4X	0.00998657762258202	0.08
ESCA	RPS4X	0.0159320502071812	0.11
DLBC	RPS4X	0.0178527424966949	0.11
ACC	RPS4X	0.0258174179323765	0.13
KICH	RPS4X	0.0282777632131697	0.13
UVM	RPS4X	0.0307650258073123	0.13
LGG	RPS4X	0.0373652499423412	0.13
THCA	RPS4X	1.29264983521118e-16	3.5e-15
BLCA	RPS4X	1.81984427155358e-05	0.00027
COAD	RPS4X	2.05972551530318e-07	3.5e-06
SKCM	RPS4X	2.15855078156193e-11	4.3e-10
THYM	RPS4X	2.21522618439435e-05	0.00031
KIRC	RPS4X	2.6250424955733e-18	7.4e-17
LUAD	RPS4X	2.69381327557207e-14	6.7e-13
LUSC	RPS4X	2.80192682695132e-11	5.3e-10
PAAD	RPS4X	3.08901316027326e-10	5.6e-09
STAD	RPS4X	3.22452762600473e-14	7.7e-13
GBM	RPS4X	3.95304679865951e-05	0.00051
HNSC	RPS4X	4.57207286941048e-14	1.1e-12
LIHC	RPS4X	6.68623666241535e-12	1.5e-10
LAML	RPS4X	7.60646085105909e-12	1.6e-10
PCPG	RPS4X	8.62498962076539e-06	0.00014
KIRP	RPS4X	9.6713250701341e-16	2.5e-14
MESO	RPS4X	9.82268403899477e-05	0.0012

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPS4X	0.000609372400610919	0.02
KIRC	RPS4X	0.0120217751293079	0.37
BRCA	RPS4X	0.00998961453074901	0.32
OV	RPS4X	0.0450613033330591	1
HNSC	RPS4X	0.0486066632882126	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0006142	Malignant neoplasm of breast	1	CTD_human
C0678222	Breast Carcinoma	1	CTD_human
C1257931	Mammary Neoplasms, Human	1	CTD_human
C4704874	Mammary Carcinoma, Human	1	CTD_human