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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPS6KA1 (NCBI Gene ID:6195)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPS6KA1
	Gene ID: 6195
	Gene Symbol	RPS6KA1
	Gene ID	6195
	Gene Name	ribosomal protein S6 kinase A1
	Synonyms	HU-1\|MAPKAPK1\|MAPKAPK1A\|RSK\|RSK1\|p90Rsk
	Cytomap	1p36.11
	Type of Gene	protein-coding
	Description	ribosomal protein S6 kinase alpha-190 kDa ribosomal protein S6 kinase 1MAP kinase-activated protein kinase 1aMAPK-activated protein kinase 1aMAPKAP kinase 1aMAPKAPK-1aRSK-1S6K-alpha 1dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1)p9
	Modification date	20200327
	UniProtAcc	Q15418

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPS6KA1	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	18402937

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPS6KA1	(355.7 - 733]

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Translation Studies in PubMed

We searched PubMed using 'RPS6KA1[title] AND translation [title] AND human.'

Gene	Title	PMID
RPS6KA1	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
BLCA	RPS6KA1	-4.84274368715488	0.00532913208007812
LUAD	RPS6KA1	-1.01040747754576	2.07702654013452e-08
BRCA	RPS6KA1	-2.37273780187266	7.30357937454372e-11
LUSC	RPS6KA1	-2.50439479306233	7.57048857587633e-10

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
LIHC	RPS6KA1	hsa-miR-342-3p	78	0.300767001209249	0.00786300854160514
OV	RPS6KA1	hsa-miR-342-3p	78	-0.319047212498933	0.0215551554748191
UCEC	RPS6KA1	hsa-miR-342-3p	78	-0.398624904507257	0.0202263159272141

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
LGG	RPS6KA1	3	2	0.00132054364416445	0.640268196509373	0.532601647014786	0.130953055734653	0.246927843605982

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
SKCM	RPS6KA1	1	2	0.00956147109859638	0.184549230769231	0.292052483801296	0.593199344518154	0.171214247326

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPS6KA1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
GBM	CGC	RPS6KA1	LYL1	0.817483034	1.37E-42
GBM	CGC	RPS6KA1	PTPN6	0.835229771	5.15E-46
GBM	IUPHAR	RPS6KA1	HAVCR2	0.800772701	1.10E-39
GBM	IUPHAR	RPS6KA1	CD33	0.806410756	1.24E-40
GBM	TF	RPS6KA1	SPI1	0.805496626	1.77E-40
GBM	TF	RPS6KA1	LYL1	0.817483034	1.37E-42
GBM	TSG	RPS6KA1	SPI1	0.805496626	1.77E-40
GBM	TSG	RPS6KA1	AIF1	0.813934797	6.01E-42
GBM	TSG	RPS6KA1	PTPN6	0.835229771	5.15E-46
GBM	TSG	RPS6KA1	PYCARD	0.836799783	2.45E-46
LGG	Cell metabolism gene	RPS6KA1	SLC2A5	0.806002446	2.43E-122
LGG	Cell metabolism gene	RPS6KA1	SQRDL	0.809727301	2.49E-124
LGG	Cell metabolism gene	RPS6KA1	FBP1	0.817394427	1.45E-128
LGG	Cell metabolism gene	RPS6KA1	PLCG2	0.823461601	4.64E-132
LGG	Cell metabolism gene	RPS6KA1	PLCB2	0.826238795	1.05E-133
LGG	Cell metabolism gene	RPS6KA1	GNGT2	0.828870765	2.73E-135
LGG	Cell metabolism gene	RPS6KA1	PIK3R5	0.83984114	3.31E-142
LGG	Cell metabolism gene	RPS6KA1	LPCAT2	0.862448014	2.90E-158
LGG	Cell metabolism gene	RPS6KA1	TBXAS1	0.863184331	7.79E-159
LGG	Cell metabolism gene	RPS6KA1	PTGS1	0.868169741	8.70E-163
LGG	Cell metabolism gene	RPS6KA1	ALOX5	0.884248849	1.00E-176
LGG	CGC	RPS6KA1	LCP1	0.806416797	1.47E-122
LGG	CGC	RPS6KA1	PTPRC	0.807897266	2.40E-123
LGG	CGC	RPS6KA1	CSF1R	0.81007472	1.62E-124
LGG	CGC	RPS6KA1	ELF4	0.810281343	1.25E-124
LGG	CGC	RPS6KA1	WAS	0.834400456	1.03E-138
LGG	CGC	RPS6KA1	IKZF1	0.835045472	4.03E-139
LGG	CGC	RPS6KA1	CEBPA	0.852356515	9.15E-151
LGG	CGC	RPS6KA1	CSF3R	0.863093345	9.16E-159
LGG	CGC	RPS6KA1	PTPN6	0.866516459	1.85E-161
LGG	CGC	RPS6KA1	BTK	0.871219157	2.76E-165
LGG	CGC	RPS6KA1	VAV1	0.880445638	3.00E-173
LGG	CGC	RPS6KA1	SYK	0.882913857	1.72E-175
LGG	Epifactor	RPS6KA1	IKZF1	0.835045472	4.03E-139
LGG	IUPHAR	RPS6KA1	LYN	0.802279399	2.14E-120
LGG	IUPHAR	RPS6KA1	GPR65	0.802904665	1.02E-120
LGG	IUPHAR	RPS6KA1	NLRC4	0.804692076	1.19E-121
LGG	IUPHAR	RPS6KA1	SLC2A5	0.806002446	2.43E-122
LGG	IUPHAR	RPS6KA1	CCR1	0.806755942	9.70E-123
LGG	IUPHAR	RPS6KA1	PTPRC	0.807897266	2.40E-123
LGG	IUPHAR	RPS6KA1	CCR5	0.80935932	3.94E-124
LGG	IUPHAR	RPS6KA1	C3AR1	0.809459327	3.48E-124
LGG	IUPHAR	RPS6KA1	CSF1R	0.81007472	1.62E-124
LGG	IUPHAR	RPS6KA1	CASP1	0.820098406	4.17E-130
LGG	IUPHAR	RPS6KA1	CSF2RB	0.820662165	1.98E-130
LGG	IUPHAR	RPS6KA1	TLR7	0.821054262	1.17E-130
LGG	IUPHAR	RPS6KA1	CYBB	0.822092974	2.93E-131
LGG	IUPHAR	RPS6KA1	PLCG2	0.823461601	4.64E-132
LGG	IUPHAR	RPS6KA1	UCP2	0.824126355	1.89E-132
LGG	IUPHAR	RPS6KA1	KCNQ1	0.825091013	5.07E-133
LGG	IUPHAR	RPS6KA1	RIPK3	0.826157419	1.18E-133
LGG	IUPHAR	RPS6KA1	PLCB2	0.826238795	1.05E-133
LGG	IUPHAR	RPS6KA1	ADAM28	0.828295379	6.09E-135
LGG	IUPHAR	RPS6KA1	S100A11	0.82873556	3.29E-135
LGG	IUPHAR	RPS6KA1	IL13RA1	0.829364259	1.36E-135
LGG	IUPHAR	RPS6KA1	CD300A	0.83075657	1.92E-136
LGG	IUPHAR	RPS6KA1	CTSZ	0.834807499	5.70E-139
LGG	IUPHAR	RPS6KA1	SLC15A3	0.834859259	5.29E-139
LGG	IUPHAR	RPS6KA1	RGS19	0.836934061	2.52E-140
LGG	IUPHAR	RPS6KA1	FCER1G	0.839169132	9.08E-142
LGG	IUPHAR	RPS6KA1	PIK3R5	0.83984114	3.31E-142
LGG	IUPHAR	RPS6KA1	RGS10	0.840828599	7.43E-143
LGG	IUPHAR	RPS6KA1	KCNK13	0.840984781	5.87E-143
LGG	IUPHAR	RPS6KA1	CD33	0.842904908	3.12E-144
LGG	IUPHAR	RPS6KA1	ITGAM	0.843206218	1.96E-144
LGG	IUPHAR	RPS6KA1	LPAR5	0.844027487	5.51E-145
LGG	IUPHAR	RPS6KA1	HCK	0.84647556	1.20E-146
LGG	IUPHAR	RPS6KA1	TRIM38	0.846574102	1.02E-146
LGG	IUPHAR	RPS6KA1	CD86	0.848080396	9.38E-148
LGG	IUPHAR	RPS6KA1	ADORA3	0.852827551	4.21E-151
LGG	IUPHAR	RPS6KA1	INPP5D	0.854540115	2.44E-152
LGG	IUPHAR	RPS6KA1	SLC7A7	0.858769903	1.83E-155
LGG	IUPHAR	RPS6KA1	ITGAL	0.859669519	3.85E-156
LGG	IUPHAR	RPS6KA1	CSF3R	0.863093345	9.16E-159
LGG	IUPHAR	RPS6KA1	TBXAS1	0.863184331	7.79E-159
LGG	IUPHAR	RPS6KA1	LILRB1	0.864016595	1.75E-159
LGG	IUPHAR	RPS6KA1	IL12RB1	0.864771389	4.47E-160
LGG	IUPHAR	RPS6KA1	PTGS1	0.868169741	8.70E-163
LGG	IUPHAR	RPS6KA1	BTK	0.871219157	2.76E-165
LGG	IUPHAR	RPS6KA1	CD37	0.872424063	2.74E-166
LGG	IUPHAR	RPS6KA1	SYK	0.882913857	1.72E-175
LGG	IUPHAR	RPS6KA1	ALOX5	0.884248849	1.00E-176
LGG	IUPHAR	RPS6KA1	LAIR1	0.885362336	9.11E-178
LGG	IUPHAR	RPS6KA1	HAVCR2	0.88960208	7.84E-182
LGG	IUPHAR	RPS6KA1	ITGB2	0.890740094	5.96E-183
LGG	Kinase	RPS6KA1	LYN	0.802279399	2.14E-120
LGG	Kinase	RPS6KA1	CSF1R	0.81007472	1.62E-124
LGG	Kinase	RPS6KA1	RIPK3	0.826157419	1.18E-133
LGG	Kinase	RPS6KA1	HCK	0.84647556	1.20E-146
LGG	Kinase	RPS6KA1	BTK	0.871219157	2.76E-165
LGG	Kinase	RPS6KA1	SYK	0.882913857	1.72E-175
LGG	TF	RPS6KA1	ELF4	0.810281343	1.25E-124
LGG	TF	RPS6KA1	TFEC	0.829896922	6.45E-136
LGG	TF	RPS6KA1	IKZF1	0.835045472	4.03E-139
LGG	TF	RPS6KA1	CEBPA	0.852356515	9.15E-151
LGG	TF	RPS6KA1	IRF5	0.855594459	4.14E-153
LGG	TF	RPS6KA1	SPI1	0.883531198	4.64E-176
LGG	TSG	RPS6KA1	PTPRC	0.807897266	2.40E-123
LGG	TSG	RPS6KA1	DOK3	0.810510622	9.40E-125
LGG	TSG	RPS6KA1	FBP1	0.817394427	1.45E-128
LGG	TSG	RPS6KA1	BLNK	0.826618359	6.23E-134
LGG	TSG	RPS6KA1	S100A11	0.82873556	3.29E-135
LGG	TSG	RPS6KA1	IKZF1	0.835045472	4.03E-139
LGG	TSG	RPS6KA1	PYCARD	0.838877175	1.41E-141
LGG	TSG	RPS6KA1	AIF1	0.846675538	8.73E-147
LGG	TSG	RPS6KA1	RNASET2	0.848972309	2.25E-148
LGG	TSG	RPS6KA1	TNFAIP8L2	0.852285086	1.03E-150
LGG	TSG	RPS6KA1	CEBPA	0.852356515	9.15E-151
LGG	TSG	RPS6KA1	ARL11	0.853871651	7.44E-152
LGG	TSG	RPS6KA1	IRF5	0.855594459	4.14E-153
LGG	TSG	RPS6KA1	PTPN6	0.866516459	1.85E-161
LGG	TSG	RPS6KA1	BTK	0.871219157	2.76E-165
LGG	TSG	RPS6KA1	SYK	0.882913857	1.72E-175
LGG	TSG	RPS6KA1	SPI1	0.883531198	4.64E-176
LGG	TSG	RPS6KA1	LAT2	0.898336493	9.31E-191
TGCT	Cell metabolism gene	RPS6KA1	RENBP	0.804307452	1.22E-36
UVM	Cell metabolism gene	RPS6KA1	HMGCL	0.803233522	3.14E-19
UVM	Epifactor	RPS6KA1	HDAC1	0.820206658	1.31E-20
UVM	IUPHAR	RPS6KA1	HDAC1	0.820206658	1.31E-20
UVM	TSG	RPS6KA1	HDAC1	0.820206658	1.31E-20

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
THCA	RPS6KA1	S100B	-1.57323578648503	0.000163107625527599
KICH	RPS6KA1	MAPK1	1.27319002595358	0.000911891460418701
BRCA	RPS6KA1	MAPK3	-1.61909976139263	0.00193136402459222
ESCA	RPS6KA1	TSC2	-3.24919207627469	0.001953125
KIRP	RPS6KA1	CEBPB	-1.31145810412787	0.00222697434946895
CHOL	RPS6KA1	CEBPB	-2.23026265318088	0.00390625
CHOL	RPS6KA1	MAPK3	-1.54068193424676	0.00390625
CHOL	RPS6KA1	TSC1	-6.69859195277734	0.00390625
PRAD	RPS6KA1	PDPK1	1.81554957286714	0.00394734627371092
LIHC	RPS6KA1	PDPK1	-1.27273782890459	0.00401886677001472
LUAD	RPS6KA1	PDPK1	-2.39037258175029	0.00557540274754635
HNSC	RPS6KA1	RPS6KA2	1.90755727061914	0.00633394569399571
LUSC	RPS6KA1	TSC2	1.12504498503233	0.00646935999315137
ESCA	RPS6KA1	RPS6KA3	1.90799647706234	0.0068359375
CHOL	RPS6KA1	CREB1	-1.73574177704588	0.0078125
HNSC	RPS6KA1	CEBPB	1.51100858014832	0.00830558335451315
UCEC	RPS6KA1	PDPK1	1.79218384802367	0.015625
BLCA	RPS6KA1	PDPK1	1.31186516278878	0.0159721374511719
STAD	RPS6KA1	TSC2	-1.66130396745917	0.018431528005749
ESCA	RPS6KA1	MAPK1	-1.17755474324053	0.0185546875
ESCA	RPS6KA1	PDPK1	-1.08809436254042	0.0244140625
UCEC	RPS6KA1	RPS6KA2	-2.51563878884087	0.03125
UCEC	RPS6KA1	RPS6KA3	2.22554023919536	0.03125
ESCA	RPS6KA1	S100B	2.66748347503258	0.0419921875
BRCA	RPS6KA1	MAPK1	-1.67954875219151	0.0427276834041307
KICH	RPS6KA1	CREB1	2.66739528597454	1.19209289550781e-07
COAD	RPS6KA1	CEBPB	-3.63250426415859	1.2814998626709e-06
KIRC	RPS6KA1	CEBPB	-1.43820294684797	1.51909432999383e-08
LIHC	RPS6KA1	TSC2	-2.06124259504281	3.59406613648813e-06
KIRC	RPS6KA1	PDPK1	-1.27456564339616	4.74133731393022e-07
COAD	RPS6KA1	MAPK3	-1.17173283146352	5.66244125366212e-07
PRAD	RPS6KA1	S100B	2.96656946450694	6.16108223613027e-08
KICH	RPS6KA1	TSC2	-5.67340295495929	6.36577606201172e-05
PRAD	RPS6KA1	CEBPB	1.66039893355835	6.51372327512043e-05
KICH	RPS6KA1	PDPK1	1.47618241053961	7.49826431274414e-05
THCA	RPS6KA1	TSC1	-2.42539568824156	7.77019962091197e-05
LUSC	RPS6KA1	RPS6KA3	-1.92441592334707	8.91464610117726e-08
LUSC	RPS6KA1	CEBPB	-2.38421489160172	9.46872220956927e-06

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPS6KA1

MAPK3, MAPK1, YWHAB, BAD, TSC1, TSC2, CARHSP1, EEF2K, NFKBIA, TOB1, CREBBP, ESR1, DDAH2, ATXN3, MPP1, PPM1G, TTK, GBP2, SRSF5, PHAX, VCP, CFL1, CCT4, MXD1, YBX1, PDCD4, RPTOR, MAPT, HSP90AA1, GYS1, GSK3B, CDKN1B, CREB1, EIF4H, GINS2, CAPN1, CASP7, CNDP2, EEF2, GNS, GSR, KYNU, LDHA, LDHB, MVD, NPEPPS, PEPD, PGD, HSP90AB1, GRN, RPS6KA3, CSNK2B, ACACA, RPS6KA2, TLK2, MASTL, POLDIP3, DLC1, ILKAP, NTRK1, SCLT1, CDC37, DEPTOR, FGFR1, UBE2T, MISP, FYN, IRGC, IL17RA, FGFR2, FAM136A, ORF45, UBR5, HRAS, KRAS, NRAS, ARHGEF12, MAST2, GOPC, PDZD7, GRID2IP, MAST1, PARD3B, PDZRN4, HTRA1, MAGI1, MAGI2, SNTG2, GORASP2, PDZK1, SNTA1, GRASP, MAGI3, ARHGEF11, SHANK3, SYNJ2BP, PDZRN3, DFNB31, SNTB1, SLC9A3R2, PTPN3, SHROOM2, LIMK2, GORASP1, LNX1, DLG4, ERBB2IP, PPP1R9A, SNX27, LTN1, TP53, HDAC2, COPG1, AP2A2, AP2M1, TAP1, ARAF, SNTB2, DDX50, AKT1, DTNA, FLOT2, DOCK4, GCLM, TELO2, TMEM97, NCAPG2, RAD21, CDC45, VPS52, INF2, MAP2K7, MTPAP, NCLN, TUBB3, AGPAT1, DHX40, ALG5, FRS2, LMF2, MORC3, PPM1F, DNAJC11, SLC16A1, AP3M1, ICMT, KAT7, LAGE3, ORC5, AP4B1, PLEKHA4, HSPA6, HSPA8, HSPA1A, HSPA5, HSP90AB2P, USP9X, DGCR2, RPS6KA1, INS, EGFR, GGA2, AR, PAPOLG, AMHR2, RAB4A, PHKG1, RAB27A, C1orf189, CTTN, ATM, STAT3,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RPS6KA1	chr1	26877972	A	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPS6KA1	BLCA	chr1	26881119	26881119	G	A	Missense_Mutation		4
RPS6KA1	KIRC	chr1	26885310	26885311	-	C	Frame_Shift_Ins	p.T366fs	4
RPS6KA1	ESCA	chr1	26898372	26898372	C	T	Silent	p.C604	3
RPS6KA1	BRCA	chr1	26885381	26885381	G	A	Missense_Mutation	p.D399N	3
RPS6KA1	LIHC	chr1	26883511	26883511	A	C	Missense_Mutation		3
RPS6KA1	LIHC	chr1	26898357	26898357	C	T	Silent		3
RPS6KA1	BLCA	chr1	26881119	26881119	G	A	Missense_Mutation	p.E216K	3
RPS6KA1	LIHC	chr1	26885311	26885311	C	-	Frame_Shift_Del	p.I366fs	3
RPS6KA1	STAD	chr1	26872519	26872519	G	A	Missense_Mutation	p.R43Q	2
RPS6KA1	ESCA	chr1	26899743	26899743	A	T	Missense_Mutation	p.D668V	2
RPS6KA1	UCEC	chr1	26900616	26900616	C	-	Frame_Shift_Del	p.T711fs	2
RPS6KA1	BRCA	chr1	26882081	26882081	G	A	Missense_Mutation	p.R303Q	2
RPS6KA1	SKCM	chr1	26872494	26872494	C	T	Missense_Mutation	p.P35S	2
RPS6KA1	UCEC	chr1	26873396	26873396	C	T	Silent	p.H58	2
RPS6KA1	COAD	chr1	26881683	26881683	C	T	Silent	p.D275D	2
RPS6KA1	ESCA	chr1	26899743	26899743	A	T	Missense_Mutation		2
RPS6KA1	HNSC	chr1	26887592	26887592	T	C	Silent		2
RPS6KA1	SKCM	chr1	26899811	26899811	C	T	Missense_Mutation	p.P682S	2
RPS6KA1	SKCM	chr1	26877949	26877949	C	T	Silent	p.F123F	2
RPS6KA1	UCEC	chr1	26898686	26898686	G	A	Missense_Mutation	p.G626S	2
RPS6KA1	HNSC	chr1	26888033	26888033	A	T	Missense_Mutation	p.E490V	2
RPS6KA1	LGG	chr1	26898350	26898350	G	T	Missense_Mutation	p.R597L	2
RPS6KA1	TGCT	chr1	26900920	26900920	A	T	Missense_Mutation		2
RPS6KA1	CESC	chr1	26873454	26873454	G	A	Missense_Mutation		2
RPS6KA1	SARC	chr1	26900607	26900607	C	T	Missense_Mutation		2
RPS6KA1	HNSC	chr1	26881104	26881104	G	C	Missense_Mutation	p.E211Q	2
RPS6KA1	SARC	chr1	26878196	26878196	C	T	Silent		2
RPS6KA1	PAAD	chr1	26872417	26872417	G	A	Missense_Mutation	p.R9H	2
RPS6KA1	GBM	chr1	26883501	26883501	C	T	Missense_Mutation	p.R332C	2
RPS6KA1	CESC	chr1	26900876	26900876	C	T	Missense_Mutation		2
RPS6KA1	LUAD	chr1	26887237	26887237	G	T	Silent	p.L412L	2
RPS6KA1	BLCA	chr1	26885394	26885394	G	T	Missense_Mutation	p.R394L	2
RPS6KA1	KIRC	chr1	26900615	26900616	-	C	Frame_Shift_Ins	p.P711fs	2
RPS6KA1	STAD	chr1	26872519	26872519	G	A	Missense_Mutation		2
RPS6KA1	COAD	chr1	26900923	26900923	T	-	3'UTR	.	2
RPS6KA1	HNSC	chr1	26877918	26877918	G	A	Missense_Mutation	p.R113K	2
RPS6KA1	LUAD	chr1	26887564	26887564	C	T	Missense_Mutation	p.S457L	2
RPS6KA1	STAD	chr1	26898396	26898396	G	T	Silent	p.L612L	2
RPS6KA1	HNSC	chr1	26898704	26898704	G	A	Missense_Mutation	p.E623K	2
RPS6KA1	LIHC	chr1	26883585	26883585	C	-	Frame_Shift_Del	p.P360fs	2
RPS6KA1	KIRP	chr1	26873742	26873742	G	A	Silent		2
RPS6KA1	LUAD	chr1	26887581	26887581	C	T	Missense_Mutation	p.L463F	2
RPS6KA1	LGG	chr1	26898350	26898350	G	T	Missense_Mutation		2
RPS6KA1	SKCM	chr1	26899811	26899811	C	T	Missense_Mutation	p.P691S	2
RPS6KA1	KIRP	chr1	26873706	26873706	G	T	Silent		1
RPS6KA1	LUAD	chr1	26882043	26882043	G	A	Missense_Mutation	p.M281I	1
RPS6KA1	SKCM	chr1	26899813	26899813	C	T	Silent	p.P682P	1
RPS6KA1	ACC	chr1	26856442	26856442	C	G	Missense_Mutation	p.P11A	1
RPS6KA1	BLCA	chr1	26898056	26898056	G	T	Silent	p.G569G	1
RPS6KA1	HNSC	chr1	26898704	26898704	G	A	Missense_Mutation		1
RPS6KA1	LGG	chr1	26900689	26900689	G	A	Silent		1
RPS6KA1	READ	chr1	26885310	26885311	-	C	Frame_Shift_Ins	p.I366fs	1
RPS6KA1	SKCM	chr1	26877903	26877903	G	A	Missense_Mutation	p.R108Q	1
RPS6KA1	STAD	chr1	26878139	26878139	C	T	Silent	p.F131F	1
RPS6KA1	STAD	chr1	26881658	26881658	G	A	Missense_Mutation	p.G258D	1
RPS6KA1	SKCM	chr1	26872468	26872468	G	A	Missense_Mutation	p.R26K	1
RPS6KA1	COAD	chr1	26873367	26873367	G	A	Missense_Mutation	p.V49I	1
RPS6KA1	HNSC	chr1	26883512	26883512	G	A	Silent	p.K335K	1
RPS6KA1	HNSC	chr1	26888041	26888041	C	T	Missense_Mutation	p.R493W	1
RPS6KA1	LIHC	chr1	26879909	26879909	T	-	Frame_Shift_Del	p.F166fs	1
RPS6KA1	SKCM	chr1	26887601	26887601	C	T	Silent	p.H478H	1
RPS6KA1	KIRP	chr1	26882106	26882106	C	A	Silent		1
RPS6KA1	LUSC	chr1	26883509	26883509	C	G	Missense_Mutation	p.I334M	1
RPS6KA1	SKCM	chr1	26881164	26881164	C	T	Missense_Mutation	p.P231S	1
RPS6KA1	STAD	chr1	26883500	26883500	T	C	Silent	p.R340R	1
RPS6KA1	BLCA	chr1	26885394	26885394	G	T	Missense_Mutation		1
RPS6KA1	STAD	chr1	26898685	26898685	C	T	Silent	p.N616N	1
RPS6KA1	HNSC	chr1	26888033	26888033	A	T	Missense_Mutation		1
RPS6KA1	LGG	chr1	26898725	26898725	G	A	Missense_Mutation		1
RPS6KA1	READ	chr1	26885383	26885383	C	T	Silent	p.D399D	1
RPS6KA1	SKCM	chr1	26885418	26885418	C	T	Missense_Mutation	p.S402L	1
RPS6KA1	SKCM	chr1	26883577	26883577	C	T	Missense_Mutation	p.S366F	1
RPS6KA1	HNSC	chr1	26888134	26888134	G	C	Missense_Mutation	p.E524Q	1
RPS6KA1	KIRC	chr1	26897964	26897964	A	T	Missense_Mutation	p.S548C	1
RPS6KA1	LIHC	chr1	26885301	26885301	C	-	Frame_Shift_Del	p.S363fs	1
RPS6KA1	KIRP	chr1	26900651	26900651	G	T	Missense_Mutation		1
RPS6KA1	LUSC	chr1	26885313	26885313	C	G	Missense_Mutation	p.P367R	1
RPS6KA1	SKCM	chr1	26877926	26877926	C	T	Silent	p.L116L	1
RPS6KA1	STAD	chr1	26878189	26878189	A	T	Missense_Mutation	p.D157V	1
RPS6KA1	STAD	chr1	26900639	26900639	T	C	Missense_Mutation	p.S719P	1
RPS6KA1	BLCA	chr1	26873469	26873469	G	C	Missense_Mutation		1
RPS6KA1	STAD	chr1	26885311	26885312	-	C	Frame_Shift_Ins	p.I366fs	1
RPS6KA1	LGG	chr1	26897963	26897963	C	A	Silent		1
RPS6KA1	SARC	chr1	26900894	26900894	G	T	Missense_Mutation		1
RPS6KA1	SKCM	chr1	26877949	26877949	C	T	Silent	p.F132F	1
RPS6KA1	COAD	chr1	26883511	26883511	A	C	Missense_Mutation	p.K344T	1
RPS6KA1	KIRC	chr1	26887302	26887302	G	A	Missense_Mutation	p.R443H	1
RPS6KA1	LIHC	chr1	26885397	26885397	C	-	Frame_Shift_Del	p.A395fs	1
RPS6KA1	MESO	chr1	26898039	26898039	C	A	Missense_Mutation		1
RPS6KA1	SKCM	chr1	26881172	26881172	C	T	Silent	p.V233V	1
RPS6KA1	STAD	chr1	26900639	26900639	T	C	Missense_Mutation	p.S728P	1
RPS6KA1	STAD	chr1	26883502	26883502	G	A	Missense_Mutation	p.R332H	1
RPS6KA1	ESCA	chr1	26898372	26898372	C	T	Silent	p.C604C	1
RPS6KA1	HNSC	chr1	26888134	26888134	G	C	Missense_Mutation		1
RPS6KA1	LIHC	chr1	26888150	26888150	A	G	Missense_Mutation		1
RPS6KA1	SARC	chr1	26900607	26900607	C	T	Missense_Mutation	p.S717F	1
RPS6KA1	SKCM	chr1	26881656	26881656	G	A	Silent	p.T257T	1
RPS6KA1	SKCM	chr1	26877901	26877901	C	T	Silent	p.V116V	1
RPS6KA1	SKCM	chr1	26873382	26873382	T	C	Missense_Mutation	p.S45P	1
RPS6KA1	COAD	chr1	26885393	26885393	C	T	Missense_Mutation	p.R403C	1
RPS6KA1	KIRC	chr1	26897964	26897964	A	T	Missense_Mutation	p.S539C	1
RPS6KA1	LIHC	chr1	26879964	26879964	T	-	Frame_Shift_Del	p.I184fs	1
RPS6KA1	LGG	chr1	26898350	26898350	G	T	Missense_Mutation	p.R588L	1
RPS6KA1	OV	chr1	26885427	26885427	A	G	Missense_Mutation	p.Q405_splice	1
RPS6KA1	SKCM	chr1	26898006	26898006	C	T	Silent	p.L553L	1
RPS6KA1	STAD	chr1	26881655	26881655	C	T	Missense_Mutation	p.T266M	1
RPS6KA1	STAD	chr1	26888152	26888152	G	C	Missense_Mutation	p.G530R	1
RPS6KA1	BLCA	chr1	26883156	26883156	G	A	Missense_Mutation		1
RPS6KA1	GBM	chr1	26885365	26885365	C	T	Silent	p.T384T	1
RPS6KA1	THCA	chr1	26897943	26897943	G	T	Missense_Mutation		1
RPS6KA1	CESC	chr1	26898762	26898763	AC	-	Frame_Shift_Del		1
RPS6KA1	HNSC	chr1	26883512	26883512	G	A	Silent		1
RPS6KA1	SARC	chr1	26878196	26878196	C	T	Silent	p.F159	1
RPS6KA1	SKCM	chr1	26887546	26887546	A	T	Missense_Mutation	p.K451M	1
RPS6KA1	SKCM	chr1	26873382	26873382	T	C	Missense_Mutation	p.S54P	1
RPS6KA1	SKCM	chr1	26888049	26888049	G	A	Silent	p.G495G	1
RPS6KA1	COAD	chr1	26888001	26888001	T	C	Silent	p.Y488Y	1
RPS6KA1	HNSC	chr1	26887589	26887589	G	T	Silent	p.R465R	1
RPS6KA1	KIRC	chr1	26887302	26887302	G	A	Missense_Mutation	p.R434H	1
RPS6KA1	LIHC	chr1	26887239	26887239	T	-	Frame_Shift_Del	p.V413fs	1
RPS6KA1	LGG	chr1	26888022	26888022	C	T	Silent	p.Y486Y	1
RPS6KA1	SKCM	chr1	26900593	26900593	C	T	Silent	p.S703S	1
RPS6KA1	STAD	chr1	26888123	26888123	G	A	Missense_Mutation	p.G529D	1
RPS6KA1	STAD	chr1	26878189	26878189	A	T	Missense_Mutation	p.D148V	1
RPS6KA1	BLCA	chr1	26898056	26898056	G	T	Silent		1
RPS6KA1	THYM	chr1	26900906	26900906	C	T	Missense_Mutation		1
RPS6KA1	HNSC	chr1	26877918	26877918	G	A	Missense_Mutation		1
RPS6KA1	SARC	chr1	26878196	26878196	C	T	Silent	p.F150F	1
RPS6KA1	SKCM	chr1	26900643	26900643	C	G	Missense_Mutation	p.S729C	1
RPS6KA1	SKCM	chr1	26873383	26873383	C	T	Missense_Mutation	p.S45F	1
RPS6KA1	SKCM	chr1	26873424	26873424	C	T	Missense_Mutation	p.P68S	1
RPS6KA1	SKCM	chr1	26873424	26873424	C	T	Missense_Mutation	p.P59S	1
RPS6KA1	COAD	chr1	26888093	26888093	G	A	Missense_Mutation	p.R519Q	1
RPS6KA1	HNSC	chr1	26887335	26887335	C	T	Missense_Mutation	p.A445V	1
RPS6KA1	LGG	chr1	26898725	26898725	G	A	Missense_Mutation	p.G630S	1
RPS6KA1	PAAD	chr1	26872417	26872417	G	A	Missense_Mutation		1
RPS6KA1	SKCM	chr1	26872489	26872489	C	T	Missense_Mutation	p.P33L	1
RPS6KA1	STAD	chr1	26898685	26898685	C	T	Silent	p.N625N	1
RPS6KA1	STAD	chr1	26883500	26883500	T	C	Silent	p.R331R	1
RPS6KA1	GBM	chr1	26885365	26885365	C	T	Silent		1
RPS6KA1	THYM	chr1	26885344	26885344	G	T	Silent		1
RPS6KA1	CESC	chr1	26898394	26898394	C	G	Missense_Mutation	p.L603V	1
RPS6KA1	HNSC	chr1	26878180	26878180	G	A	Missense_Mutation		1
RPS6KA1	LIHC	chr1	26878156	26878156	T	C	Missense_Mutation		1
RPS6KA1	SARC	chr1	26900607	26900607	C	T	Missense_Mutation	p.S708F	1
RPS6KA1	SKCM	chr1	26877926	26877926	C	T	Silent	p.L125L	1
RPS6KA1	SKCM	chr1	26873441	26873441	C	T	Silent	p.L64L	1
RPS6KA1	SKCM	chr1	26873441	26873441	C	T	Silent	p.L73L	1
RPS6KA1	STAD	chr1	26885311	26885311	C	-	Frame_Shift_Del		1
RPS6KA1	COAD	chr1	26898055	26898055	G	A	Missense_Mutation	p.G578E	1
RPS6KA1	HNSC	chr1	26898043	26898043	G	A	Missense_Mutation	p.R565Q	1
RPS6KA1	LUAD	chr1	26888135	26888135	A	G	Missense_Mutation	p.E524G	1
RPS6KA1	LGG	chr1	26900689	26900689	G	A	Silent	p.L735L	1
RPS6KA1	PRAD	chr1	26883148	26883148	C	T	Missense_Mutation	p.S316F	1
RPS6KA1	SKCM	chr1	26877901	26877901	C	T	Silent	p.V107V	1
RPS6KA1	STAD	chr1	26888152	26888152	G	C	Missense_Mutation	p.G539R	1
RPS6KA1	STAD	chr1	26888072	26888072	G	A	Missense_Mutation	p.R503Q	1
RPS6KA1	BLCA	chr1	26873469	26873469	G	C	Missense_Mutation	p.G74R	1
RPS6KA1	GBM	chr1	26885383	26885383	C	T	Silent		1
RPS6KA1	THYM	chr1	26885344	26885344	G	T	Silent	p.R386R	1
RPS6KA1	CESC	chr1	26898762	26898763	AC	-	Frame_Shift_Del	p.N642fs	1
RPS6KA1	HNSC	chr1	26881104	26881104	G	C	Missense_Mutation		1
RPS6KA1	LIHC	chr1	26881119	26881119	G	A	Missense_Mutation	p.E225K	1
RPS6KA1	SKCM	chr1	26885410	26885410	C	T	Silent	p.P408P	1
RPS6KA1	SKCM	chr1	26900643	26900643	C	G	Missense_Mutation	p.S720C	1
RPS6KA1	SKCM	chr1	26888049	26888049	G	A	Silent	p.G504G	1
RPS6KA1	KIRP	chr1	26856462	26856462	T	G	Silent	p.P17P	1
RPS6KA1	LUAD	chr1	26881201	26881201	C	T	Missense_Mutation	p.A243V	1
RPS6KA1	LGG	chr1	26888068	26888068	C	A	Missense_Mutation	p.L502M	1
RPS6KA1	PRAD	chr1	26898078	26898078	A	G	Missense_Mutation	p.T577A	1
RPS6KA1	SKCM	chr1	26900586	26900586	C	T	Missense_Mutation	p.T701M	1
RPS6KA1	STAD	chr1	26881658	26881658	G	A	Missense_Mutation	p.G267D	1
RPS6KA1	STAD	chr1	26888123	26888123	G	A	Missense_Mutation	p.G520D	1
RPS6KA1	GBM	chr1	26887589	26887589	G	A	Silent		1
RPS6KA1	THYM	chr1	26898704	26898704	G	T	Nonsense_Mutation	p.E632X	1
RPS6KA1	CESC	chr1	26898762	26898763	AC	-	Frame_Shift_Del	p.T652fs	1
RPS6KA1	HNSC	chr1	26887287	26887288	-	-	Frame_Shift_Ins		1
RPS6KA1	LIHC	chr1	26900660	26900660	C	A	Silent	p.R735R	1
RPS6KA1	SKCM	chr1	26877903	26877903	G	A	Missense_Mutation	p.R117Q	1
RPS6KA1	SKCM	chr1	26883577	26883577	C	T	Missense_Mutation	p.S357F	1
RPS6KA1	KIRP	chr1	26885310	26885310	T	C	Missense_Mutation	p.I366T	1
RPS6KA1	SKCM	chr1	26873383	26873383	C	T	Missense_Mutation	p.S54F	1
RPS6KA1	STAD	chr1	26878139	26878139	C	T	Silent		1
RPS6KA1	COAD	chr1	26881656	26881656	G	A	Silent	p.T266T	1
RPS6KA1	GBM	chr1	26883501	26883501	C	T	Missense_Mutation		1
RPS6KA1	LGG	chr1	26888117	26888117	C	-	Frame_Shift_Del	p.T518fs	1
RPS6KA1	PRAD	chr1	26872461	26872461	C	T	Missense_Mutation	p.R24W	1
RPS6KA1	SKCM	chr1	26873464	26873464	C	T	Missense_Mutation	p.S72F	1
RPS6KA1	STAD	chr1	26881655	26881655	C	T	Missense_Mutation	p.T257M	1
RPS6KA1	BLCA	chr1	26883156	26883156	G	A	Missense_Mutation	p.D310N	1
RPS6KA1	THYM	chr1	26887295	26887295	T	A	Missense_Mutation	p.C441S	1
RPS6KA1	COAD	chr1	26863453	26863453	C	T	Missense_Mutation	p.P34L	1
RPS6KA1	HNSC	chr1	26898043	26898043	G	A	Missense_Mutation		1
RPS6KA1	SKCM	chr1	26887546	26887546	A	T	Missense_Mutation	p.K460M	1
RPS6KA1	SKCM	chr1	26863424	26863424	G	A	Silent	p.Q24Q	1
RPS6KA1	SKCM	chr1	26887601	26887601	C	T	Silent	p.H469H	1
RPS6KA1	STAD	chr1	26885311	26885311	C	-	Frame_Shift_Del	p.I375fs	1
RPS6KA1	COAD	chr1	26897999	26897999	C	T	Silent	p.P550P	1
RPS6KA1	BLCA	chr1	26879984	26879984	G	A	Missense_Mutation	p.E191K	1
RPS6KA1	HNSC	chr1	26888041	26888041	C	T	Missense_Mutation		1
RPS6KA1	PRAD	chr1	26883148	26883148	C	T	Missense_Mutation	p.S307F	1
RPS6KA1	SKCM	chr1	26873435	26873435	C	T	Silent	p.F62F	1
RPS6KA1	STAD	chr1	26888072	26888072	G	A	Missense_Mutation	p.R512Q	1
RPS6KA1	STAD	chr1	26898396	26898396	G	T	Silent	p.L603L	1
RPS6KA1	UCEC	chr1	26873367	26873367	G	A	Missense_Mutation	p.V40I	1
RPS6KA1	COAD	chr1	26872518	26872518	C	T	Missense_Mutation	p.R43W	1
RPS6KA1	HNSC	chr1	26878180	26878180	G	A	Missense_Mutation	p.R145H	1
RPS6KA1	HNSC	chr1	26887287	26887288	-	CT	Frame_Shift_Ins	p.F429fs	1
RPS6KA1	SKCM	chr1	26885410	26885410	C	T	Silent	p.P399P	1

Copy number variation (CNV) of RPS6KA1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPS6KA1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
91322	LAML	TCGA-AB-2981-03B	ARID1A	chr1	27105774	+	RPS6KA1	chr1	26873403	+
91322	STAD	TCGA-HU-A4GH	ARID1A	chr1	27102198	+	RPS6KA1	chr1	26897939	+
91322	STAD	TCGA-HU-A4GH-01A	ARID1A	chr1	27102198	+	RPS6KA1	chr1	26897940	+
91322	BRCA	TCGA-OL-A5RZ-01A	FGGY	chr1	59978111	-	RPS6KA1	chr1	26863416	+
77987	LUAD	TCGA-55-8085-01A	RPS6KA1	chr1	26885428	+	LIN28A	chr1	26751794	+
77987	BRCA	TCGA-E2-A106	RPS6KA1	chr1	26863460	+	RASGRP3	chr2	33759389	+
77987	BRCA	TCGA-E2-A106-01A	RPS6KA1	chr1	26863460	+	RASGRP3	chr2	33759390	+
91322	N/A	AI821088	RPS6KA1	chr1	26711702	-	RPS6KA1	chr1	26867720	-
91322	N/A	AI821834	RPS6KA1	chr1	26868025	+	RPS6KA1	chr1	26867246	+
91327	N/A	DA446811	TMBIM6	chr12	50152178	+	RPS6KA1	chr1	26894691	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUAD	RPS6KA1	0.000116696418898684	0.0032
KIRC	RPS6KA1	0.00210668769822324	0.055
BRCA	RPS6KA1	0.033036238289207	0.83
KIRP	RPS6KA1	3.4877351738996e-07	9.8e-06

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRP	RPS6KA1	0.0131723480301998	0.41
LAML	RPS6KA1	0.00157258201941671	0.052
BRCA	RPS6KA1	0.00836551340614956	0.27
BLCA	RPS6KA1	0.0481484234754912	1
THYM	RPS6KA1	0.0277616658329352	0.83

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Q15418	DB04751	Purvalanol A		Small molecule	Experimental
Q15418	DB04751	Purvalanol A

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0015923	Fetal Alcohol Syndrome	1	CTD_human
C0036920	Sezary Syndrome	1	CTD_human
C0814154	Alcohol Related Neurodevelopmental Disorder	1	CTD_human
C3146244	Alcohol Related Birth Defect	1	CTD_human
C3661483	Partial Fetal Alcohol Syndrome	1	CTD_human