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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPS6KB2 (NCBI Gene ID:6199)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPS6KB2
	Gene ID: 6199
	Gene Symbol	RPS6KB2
	Gene ID	6199
	Gene Name	ribosomal protein S6 kinase B2
	Synonyms	KLS\|P70-beta\|P70-beta-1\|P70-beta-2\|S6K-beta2\|S6K2\|S6KB\|S6KI(2)\|S6Kbeta\|SRK\|STK14B\|p70(S6K)-beta\|p70S6Kb
	Cytomap	11q13.2
	Type of Gene	protein-coding
	Description	ribosomal protein S6 kinase beta-270 kDa ribosomal protein S6 kinase 2P70S6K2S6 kinase-related kinaseS6K-betaS6K-beta-2p70 S6 kinase betap70 S6K-betap70 S6KBp70 ribosomal S6 kinase betap70-S6K 2ribosomal protein S6 kinase, 70kDa, polypeptide 2
	Modification date	20200313
	UniProtAcc	Q9UBS0

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0045727	Positive regulation of translation
GO:0006413	Translational initiation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPS6KB2	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPS6KB2[title] AND translation [title] AND human.'

Gene	Title	PMID
RPS6KB2	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000312629	67196452	67196493	Frame-shift
ENST00000312629	67198838	67198986	Frame-shift
ENST00000312629	67200070	67200128	Frame-shift
ENST00000312629	67200207	67200308	Frame-shift
ENST00000312629	67200596	67200687	Frame-shift
ENST00000312629	67201465	67201528	In-frame
ENST00000312629	67202052	67202165	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000312629	67201465	67201528	1743	952	1014	482	302	323

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q9UBS0	302	323	1	482	Chain	ID=PRO_0000086214;Note=Ribosomal protein S6 kinase beta-2
Q9UBS0	302	323	67	328	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9UBS0	302	323	155	482	Alternative sequence	ID=VSP_056442;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KICH	RPS6KB2	-4.22026554870888	0.000911891460418701
THCA	RPS6KB2	-1.02516199753119	0.00125200545023797
BRCA	RPS6KB2	-1.61361650027185	6.83985375255908e-15

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
THYM	RPS6KB2	0.167203313	0.03589984

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPS6KB2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
KICH	Cell metabolism gene	RPS6KB2	PSMC3	0.820374498	2.55E-23
KICH	Epifactor	RPS6KB2	BRMS1	0.835995516	6.38E-25
KICH	TSG	RPS6KB2	BRMS1	0.835995516	6.38E-25
LAML	Cell metabolism gene	RPS6KB2	GUK1	0.828619636	6.03E-45
LAML	IUPHAR	RPS6KB2	SCYL1	0.821944674	1.17E-43
LAML	Kinase	RPS6KB2	SCYL1	0.821944674	1.17E-43
LAML	TSG	RPS6KB2	SCYL1	0.821944674	1.17E-43
THYM	Cell metabolism gene	RPS6KB2	PSMD8	0.801792336	1.33E-28
THYM	Cell metabolism gene	RPS6KB2	HMBS	0.802415269	1.13E-28
THYM	Cell metabolism gene	RPS6KB2	POLR2E	0.802743528	1.03E-28
THYM	Cell metabolism gene	RPS6KB2	APOA1	0.807708857	2.62E-29
THYM	Cell metabolism gene	RPS6KB2	POLR2H	0.808404944	2.15E-29
THYM	Cell metabolism gene	RPS6KB2	PAFAH1B3	0.809090266	1.77E-29
THYM	Cell metabolism gene	RPS6KB2	TOMM40	0.809567473	1.55E-29
THYM	Cell metabolism gene	RPS6KB2	PREB	0.81090423	1.06E-29
THYM	Cell metabolism gene	RPS6KB2	PSMA4	0.812415146	6.87E-30
THYM	Cell metabolism gene	RPS6KB2	PCYT2	0.81292626	5.93E-30
THYM	Cell metabolism gene	RPS6KB2	AAAS	0.814247679	4.04E-30
THYM	Cell metabolism gene	RPS6KB2	DGUOK	0.814282774	4.00E-30
THYM	Cell metabolism gene	RPS6KB2	TIMM50	0.819543394	8.44E-31
THYM	Cell metabolism gene	RPS6KB2	SRM	0.819631149	8.22E-31
THYM	Cell metabolism gene	RPS6KB2	LSM3	0.820027221	7.29E-31
THYM	Cell metabolism gene	RPS6KB2	PSMB10	0.821346303	4.89E-31
THYM	Cell metabolism gene	RPS6KB2	NOP56	0.822727962	3.21E-31
THYM	Cell metabolism gene	RPS6KB2	PSME1	0.826585996	9.68E-32
THYM	Cell metabolism gene	RPS6KB2	SNRPD1	0.827117966	8.19E-32
THYM	Cell metabolism gene	RPS6KB2	APRT	0.827584966	7.07E-32
THYM	Cell metabolism gene	RPS6KB2	MED18	0.827742597	6.72E-32
THYM	Cell metabolism gene	RPS6KB2	GCDH	0.830058029	3.21E-32
THYM	Cell metabolism gene	RPS6KB2	SLC27A5	0.836982813	3.29E-33
THYM	Cell metabolism gene	RPS6KB2	LSM2	0.838117498	2.24E-33
THYM	Cell metabolism gene	RPS6KB2	FAU	0.838301678	2.11E-33
THYM	Cell metabolism gene	RPS6KB2	EBP	0.838938396	1.70E-33
THYM	Cell metabolism gene	RPS6KB2	PSMA5	0.840606722	9.58E-34
THYM	Cell metabolism gene	RPS6KB2	PSMB2	0.843929306	3.00E-34
THYM	Cell metabolism gene	RPS6KB2	POLD1	0.844088436	2.84E-34
THYM	Cell metabolism gene	RPS6KB2	PMPCA	0.845878456	1.50E-34
THYM	Cell metabolism gene	RPS6KB2	PHKG2	0.847200591	9.34E-35
THYM	Cell metabolism gene	RPS6KB2	LSM4	0.847517709	8.33E-35
THYM	Cell metabolism gene	RPS6KB2	EXOSC4	0.847558822	8.20E-35
THYM	Cell metabolism gene	RPS6KB2	MTMR14	0.84777356	7.59E-35
THYM	Cell metabolism gene	RPS6KB2	PSMB7	0.850706826	2.59E-35
THYM	Cell metabolism gene	RPS6KB2	TIMM17B	0.852417746	1.37E-35
THYM	Cell metabolism gene	RPS6KB2	MVD	0.853712356	8.39E-36
THYM	Cell metabolism gene	RPS6KB2	POLD4	0.853833078	8.02E-36
THYM	Cell metabolism gene	RPS6KB2	TIMM8B	0.854816942	5.51E-36
THYM	Cell metabolism gene	RPS6KB2	DGKZ	0.855869039	3.68E-36
THYM	Cell metabolism gene	RPS6KB2	SNRPB	0.858516094	1.31E-36
THYM	Cell metabolism gene	RPS6KB2	POLD2	0.859271633	9.76E-37
THYM	Cell metabolism gene	RPS6KB2	ACADS	0.863208318	2.01E-37
THYM	Cell metabolism gene	RPS6KB2	TALDO1	0.865131902	9.13E-38
THYM	Cell metabolism gene	RPS6KB2	OAZ1	0.86582848	6.84E-38
THYM	Cell metabolism gene	RPS6KB2	PGP	0.86625949	5.71E-38
THYM	Cell metabolism gene	RPS6KB2	POLR3K	0.867671846	3.16E-38
THYM	Cell metabolism gene	RPS6KB2	POLA2	0.870557384	9.19E-39
THYM	Cell metabolism gene	RPS6KB2	GUK1	0.874701612	1.48E-39
THYM	Cell metabolism gene	RPS6KB2	PSMB3	0.875704601	9.44E-40
THYM	Cell metabolism gene	RPS6KB2	SNRPD2	0.879364075	1.76E-40
THYM	Cell metabolism gene	RPS6KB2	GALK1	0.883656971	2.28E-41
THYM	Cell metabolism gene	RPS6KB2	TIMM13	0.886344743	6.10E-42
THYM	Cell metabolism gene	RPS6KB2	DTYMK	0.886538807	5.54E-42
THYM	Cell metabolism gene	RPS6KB2	ACOT8	0.896225254	3.52E-44
THYM	Cell metabolism gene	RPS6KB2	PSMD13	0.904287437	3.52E-46
THYM	Cell metabolism gene	RPS6KB2	FPGS	0.904590441	2.94E-46
THYM	Cell metabolism gene	RPS6KB2	PSMC3	0.923495795	9.16E-52
THYM	CGC	RPS6KB2	BAX	0.80504639	5.48E-29
THYM	CGC	RPS6KB2	RBM10	0.832822242	1.31E-32
THYM	CGC	RPS6KB2	POLD1	0.844088436	2.84E-34
THYM	CGC	RPS6KB2	TFPT	0.884229458	1.73E-41
THYM	CGC	RPS6KB2	SDHAF2	0.930826564	2.71E-54
THYM	Epifactor	RPS6KB2	H2AFX	0.805091933	5.41E-29
THYM	Epifactor	RPS6KB2	ZNHIT1	0.812077163	7.58E-30
THYM	Epifactor	RPS6KB2	SIRT7	0.817555849	1.53E-30
THYM	Epifactor	RPS6KB2	MAZ	0.82090039	5.60E-31
THYM	Epifactor	RPS6KB2	FBL	0.825333713	1.43E-31
THYM	Epifactor	RPS6KB2	RRP8	0.828942476	4.59E-32
THYM	Epifactor	RPS6KB2	C17orf49	0.835702953	5.06E-33
THYM	Epifactor	RPS6KB2	SIRT6	0.837006294	3.27E-33
THYM	Epifactor	RPS6KB2	NAP1L4	0.840900186	8.65E-34
THYM	Epifactor	RPS6KB2	EXOSC4	0.847558822	8.20E-35
THYM	Epifactor	RPS6KB2	PRPF31	0.849344786	4.28E-35
THYM	Epifactor	RPS6KB2	TRIM28	0.851295587	2.08E-35
THYM	Epifactor	RPS6KB2	ZGPAT	0.863472282	1.81E-37
THYM	Epifactor	RPS6KB2	MCRS1	0.86488924	1.01E-37
THYM	Epifactor	RPS6KB2	MBD3	0.86561642	7.47E-38
THYM	Epifactor	RPS6KB2	RUVBL2	0.866139535	6.00E-38
THYM	Epifactor	RPS6KB2	NOC2L	0.867397257	3.54E-38
THYM	Epifactor	RPS6KB2	PPM1G	0.879831905	1.41E-40
THYM	Epifactor	RPS6KB2	TFPT	0.884229458	1.73E-41
THYM	Epifactor	RPS6KB2	TAF10	0.88844318	2.13E-42
THYM	Epifactor	RPS6KB2	CXXC1	0.88924083	1.42E-42
THYM	Epifactor	RPS6KB2	BRMS1	0.914921605	4.15E-49
THYM	Epifactor	RPS6KB2	PPP4C	0.918103248	4.64E-50
THYM	IUPHAR	RPS6KB2	STK16	0.813210832	5.46E-30
THYM	IUPHAR	RPS6KB2	SIRT7	0.817555849	1.53E-30
THYM	IUPHAR	RPS6KB2	RNPEPL1	0.82660631	9.62E-32
THYM	IUPHAR	RPS6KB2	MFSD2B	0.834153384	8.46E-33
THYM	IUPHAR	RPS6KB2	SLC27A5	0.836982813	3.29E-33
THYM	IUPHAR	RPS6KB2	SIRT6	0.837006294	3.27E-33
THYM	IUPHAR	RPS6KB2	CSK	0.840143372	1.12E-33
THYM	IUPHAR	RPS6KB2	PSMB2	0.843929306	3.00E-34
THYM	IUPHAR	RPS6KB2	EGLN2	0.844701354	2.29E-34
THYM	IUPHAR	RPS6KB2	PHKG2	0.847200591	9.34E-35
THYM	IUPHAR	RPS6KB2	TRIM28	0.851295587	2.08E-35
THYM	IUPHAR	RPS6KB2	MVD	0.853712356	8.39E-36
THYM	IUPHAR	RPS6KB2	TWF2	0.869687791	1.34E-38
THYM	Kinase	RPS6KB2	STK16	0.813210832	5.46E-30
THYM	Kinase	RPS6KB2	ADCK4	0.82277394	3.16E-31
THYM	Kinase	RPS6KB2	CSK	0.840143372	1.12E-33
THYM	Kinase	RPS6KB2	PHKG2	0.847200591	9.34E-35
THYM	Kinase	RPS6KB2	TRIM28	0.851295587	2.08E-35
THYM	TF	RPS6KB2	ZNF787	0.804295388	6.74E-29
THYM	TF	RPS6KB2	PREB	0.81090423	1.06E-29
THYM	TF	RPS6KB2	ZNF428	0.813503617	5.02E-30
THYM	TF	RPS6KB2	DRAP1	0.815546754	2.77E-30
THYM	TF	RPS6KB2	USF1	0.817004941	1.80E-30
THYM	TF	RPS6KB2	ZNF653	0.819552714	8.41E-31
THYM	TF	RPS6KB2	MAZ	0.82090039	5.60E-31
THYM	TF	RPS6KB2	NAIF1	0.822882623	3.06E-31
THYM	TF	RPS6KB2	GTF3A	0.823636448	2.43E-31
THYM	TF	RPS6KB2	THYN1	0.824110137	2.10E-31
THYM	TF	RPS6KB2	IRF3	0.833155201	1.17E-32
THYM	TF	RPS6KB2	RBCK1	0.846108432	1.38E-34
THYM	TF	RPS6KB2	ZNF688	0.857812515	1.73E-36
THYM	TF	RPS6KB2	ZNF444	0.859183575	1.01E-36
THYM	TF	RPS6KB2	ZGPAT	0.863472282	1.81E-37
THYM	TF	RPS6KB2	MBD3	0.86561642	7.47E-38
THYM	TF	RPS6KB2	ZBTB17	0.870930037	7.82E-39
THYM	TF	RPS6KB2	ZNF668	0.871250894	6.80E-39
THYM	TF	RPS6KB2	PIN1	0.880282001	1.14E-40
THYM	TF	RPS6KB2	CXXC1	0.88924083	1.42E-42
THYM	TSG	RPS6KB2	GNB2L1	0.803016023	9.56E-29
THYM	TSG	RPS6KB2	BAX	0.80504639	5.48E-29
THYM	TSG	RPS6KB2	H2AFX	0.805091933	5.41E-29
THYM	TSG	RPS6KB2	HTRA2	0.806674169	3.49E-29
THYM	TSG	RPS6KB2	FZR1	0.8085488	2.07E-29
THYM	TSG	RPS6KB2	CYB561D2	0.809813628	1.45E-29
THYM	TSG	RPS6KB2	GLTSCR2	0.820024127	7.30E-31
THYM	TSG	RPS6KB2	IRF3	0.833155201	1.17E-32
THYM	TSG	RPS6KB2	SIRT6	0.837006294	3.27E-33
THYM	TSG	RPS6KB2	NPRL2	0.84306349	4.07E-34
THYM	TSG	RPS6KB2	ZNF668	0.871250894	6.80E-39
THYM	TSG	RPS6KB2	PFN1	0.871497802	6.11E-39
THYM	TSG	RPS6KB2	PIN1	0.880282001	1.14E-40
THYM	TSG	RPS6KB2	AIP	0.88641834	5.88E-42
THYM	TSG	RPS6KB2	TSSC4	0.898432233	1.04E-44
THYM	TSG	RPS6KB2	BRMS1	0.914921605	4.15E-49
UCS	Cell metabolism gene	RPS6KB2	PSMD8	0.801792336	1.33E-28
UCS	Cell metabolism gene	RPS6KB2	HMBS	0.802415269	1.13E-28
UCS	Cell metabolism gene	RPS6KB2	POLR2E	0.802743528	1.03E-28
UCS	Cell metabolism gene	RPS6KB2	APOA1	0.807708857	2.62E-29
UCS	Cell metabolism gene	RPS6KB2	POLR2H	0.808404944	2.15E-29
UCS	Cell metabolism gene	RPS6KB2	PAFAH1B3	0.809090266	1.77E-29
UCS	Cell metabolism gene	RPS6KB2	TOMM40	0.809567473	1.55E-29
UCS	Cell metabolism gene	RPS6KB2	PREB	0.81090423	1.06E-29
UCS	Cell metabolism gene	RPS6KB2	PSMA4	0.812415146	6.87E-30
UCS	Cell metabolism gene	RPS6KB2	PCYT2	0.81292626	5.93E-30
UCS	Cell metabolism gene	RPS6KB2	AAAS	0.814247679	4.04E-30
UCS	Cell metabolism gene	RPS6KB2	DGUOK	0.814282774	4.00E-30
UCS	Cell metabolism gene	RPS6KB2	TIMM50	0.819543394	8.44E-31
UCS	Cell metabolism gene	RPS6KB2	SRM	0.819631149	8.22E-31
UCS	Cell metabolism gene	RPS6KB2	LSM3	0.820027221	7.29E-31
UCS	Cell metabolism gene	RPS6KB2	PSMB10	0.821346303	4.89E-31
UCS	Cell metabolism gene	RPS6KB2	NOP56	0.822727962	3.21E-31
UCS	Cell metabolism gene	RPS6KB2	PSME1	0.826585996	9.68E-32
UCS	Cell metabolism gene	RPS6KB2	SNRPD1	0.827117966	8.19E-32
UCS	Cell metabolism gene	RPS6KB2	APRT	0.827584966	7.07E-32
UCS	Cell metabolism gene	RPS6KB2	MED18	0.827742597	6.72E-32
UCS	Cell metabolism gene	RPS6KB2	GCDH	0.830058029	3.21E-32
UCS	Cell metabolism gene	RPS6KB2	SLC27A5	0.836982813	3.29E-33
UCS	Cell metabolism gene	RPS6KB2	LSM2	0.838117498	2.24E-33
UCS	Cell metabolism gene	RPS6KB2	FAU	0.838301678	2.11E-33
UCS	Cell metabolism gene	RPS6KB2	EBP	0.838938396	1.70E-33
UCS	Cell metabolism gene	RPS6KB2	PSMA5	0.840606722	9.58E-34
UCS	Cell metabolism gene	RPS6KB2	PSMB2	0.843929306	3.00E-34
UCS	Cell metabolism gene	RPS6KB2	POLD1	0.844088436	2.84E-34
UCS	Cell metabolism gene	RPS6KB2	PMPCA	0.845878456	1.50E-34
UCS	Cell metabolism gene	RPS6KB2	PHKG2	0.847200591	9.34E-35
UCS	Cell metabolism gene	RPS6KB2	LSM4	0.847517709	8.33E-35
UCS	Cell metabolism gene	RPS6KB2	EXOSC4	0.847558822	8.20E-35
UCS	Cell metabolism gene	RPS6KB2	MTMR14	0.84777356	7.59E-35
UCS	Cell metabolism gene	RPS6KB2	PSMB7	0.850706826	2.59E-35
UCS	Cell metabolism gene	RPS6KB2	TIMM17B	0.852417746	1.37E-35
UCS	Cell metabolism gene	RPS6KB2	MVD	0.853712356	8.39E-36
UCS	Cell metabolism gene	RPS6KB2	POLD4	0.853833078	8.02E-36
UCS	Cell metabolism gene	RPS6KB2	TIMM8B	0.854816942	5.51E-36
UCS	Cell metabolism gene	RPS6KB2	DGKZ	0.855869039	3.68E-36
UCS	Cell metabolism gene	RPS6KB2	SNRPB	0.858516094	1.31E-36
UCS	Cell metabolism gene	RPS6KB2	POLD2	0.859271633	9.76E-37
UCS	Cell metabolism gene	RPS6KB2	ACADS	0.863208318	2.01E-37
UCS	Cell metabolism gene	RPS6KB2	TALDO1	0.865131902	9.13E-38
UCS	Cell metabolism gene	RPS6KB2	OAZ1	0.86582848	6.84E-38
UCS	Cell metabolism gene	RPS6KB2	PGP	0.86625949	5.71E-38
UCS	Cell metabolism gene	RPS6KB2	POLR3K	0.867671846	3.16E-38
UCS	Cell metabolism gene	RPS6KB2	POLA2	0.870557384	9.19E-39
UCS	Cell metabolism gene	RPS6KB2	GUK1	0.874701612	1.48E-39
UCS	Cell metabolism gene	RPS6KB2	PSMB3	0.875704601	9.44E-40
UCS	Cell metabolism gene	RPS6KB2	SNRPD2	0.879364075	1.76E-40
UCS	Cell metabolism gene	RPS6KB2	GALK1	0.883656971	2.28E-41
UCS	Cell metabolism gene	RPS6KB2	TIMM13	0.886344743	6.10E-42
UCS	Cell metabolism gene	RPS6KB2	DTYMK	0.886538807	5.54E-42
UCS	Cell metabolism gene	RPS6KB2	ACOT8	0.896225254	3.52E-44
UCS	Cell metabolism gene	RPS6KB2	PSMD13	0.904287437	3.52E-46
UCS	Cell metabolism gene	RPS6KB2	FPGS	0.904590441	2.94E-46
UCS	Cell metabolism gene	RPS6KB2	PSMC3	0.923495795	9.16E-52
UCS	CGC	RPS6KB2	BAX	0.80504639	5.48E-29
UCS	CGC	RPS6KB2	RBM10	0.832822242	1.31E-32
UCS	CGC	RPS6KB2	POLD1	0.844088436	2.84E-34
UCS	CGC	RPS6KB2	TFPT	0.884229458	1.73E-41
UCS	CGC	RPS6KB2	SDHAF2	0.930826564	2.71E-54
UCS	Epifactor	RPS6KB2	H2AFX	0.805091933	5.41E-29
UCS	Epifactor	RPS6KB2	ZNHIT1	0.812077163	7.58E-30
UCS	Epifactor	RPS6KB2	SIRT7	0.817555849	1.53E-30
UCS	Epifactor	RPS6KB2	MAZ	0.82090039	5.60E-31
UCS	Epifactor	RPS6KB2	FBL	0.825333713	1.43E-31
UCS	Epifactor	RPS6KB2	RRP8	0.828942476	4.59E-32
UCS	Epifactor	RPS6KB2	C17orf49	0.835702953	5.06E-33
UCS	Epifactor	RPS6KB2	SIRT6	0.837006294	3.27E-33
UCS	Epifactor	RPS6KB2	NAP1L4	0.840900186	8.65E-34
UCS	Epifactor	RPS6KB2	EXOSC4	0.847558822	8.20E-35
UCS	Epifactor	RPS6KB2	PRPF31	0.849344786	4.28E-35
UCS	Epifactor	RPS6KB2	TRIM28	0.851295587	2.08E-35
UCS	Epifactor	RPS6KB2	ZGPAT	0.863472282	1.81E-37
UCS	Epifactor	RPS6KB2	MCRS1	0.86488924	1.01E-37
UCS	Epifactor	RPS6KB2	MBD3	0.86561642	7.47E-38
UCS	Epifactor	RPS6KB2	RUVBL2	0.866139535	6.00E-38
UCS	Epifactor	RPS6KB2	NOC2L	0.867397257	3.54E-38
UCS	Epifactor	RPS6KB2	PPM1G	0.879831905	1.41E-40
UCS	Epifactor	RPS6KB2	TFPT	0.884229458	1.73E-41
UCS	Epifactor	RPS6KB2	TAF10	0.88844318	2.13E-42
UCS	Epifactor	RPS6KB2	CXXC1	0.88924083	1.42E-42
UCS	Epifactor	RPS6KB2	BRMS1	0.914921605	4.15E-49
UCS	Epifactor	RPS6KB2	PPP4C	0.918103248	4.64E-50
UCS	IUPHAR	RPS6KB2	STK16	0.813210832	5.46E-30
UCS	IUPHAR	RPS6KB2	SIRT7	0.817555849	1.53E-30
UCS	IUPHAR	RPS6KB2	RNPEPL1	0.82660631	9.62E-32
UCS	IUPHAR	RPS6KB2	MFSD2B	0.834153384	8.46E-33
UCS	IUPHAR	RPS6KB2	SLC27A5	0.836982813	3.29E-33
UCS	IUPHAR	RPS6KB2	SIRT6	0.837006294	3.27E-33
UCS	IUPHAR	RPS6KB2	CSK	0.840143372	1.12E-33
UCS	IUPHAR	RPS6KB2	PSMB2	0.843929306	3.00E-34
UCS	IUPHAR	RPS6KB2	EGLN2	0.844701354	2.29E-34
UCS	IUPHAR	RPS6KB2	PHKG2	0.847200591	9.34E-35
UCS	IUPHAR	RPS6KB2	TRIM28	0.851295587	2.08E-35
UCS	IUPHAR	RPS6KB2	MVD	0.853712356	8.39E-36
UCS	IUPHAR	RPS6KB2	TWF2	0.869687791	1.34E-38
UCS	Kinase	RPS6KB2	STK16	0.813210832	5.46E-30
UCS	Kinase	RPS6KB2	ADCK4	0.82277394	3.16E-31
UCS	Kinase	RPS6KB2	CSK	0.840143372	1.12E-33
UCS	Kinase	RPS6KB2	PHKG2	0.847200591	9.34E-35
UCS	Kinase	RPS6KB2	TRIM28	0.851295587	2.08E-35
UCS	TF	RPS6KB2	ZNF787	0.804295388	6.74E-29
UCS	TF	RPS6KB2	PREB	0.81090423	1.06E-29
UCS	TF	RPS6KB2	ZNF428	0.813503617	5.02E-30
UCS	TF	RPS6KB2	DRAP1	0.815546754	2.77E-30
UCS	TF	RPS6KB2	USF1	0.817004941	1.80E-30
UCS	TF	RPS6KB2	ZNF653	0.819552714	8.41E-31
UCS	TF	RPS6KB2	MAZ	0.82090039	5.60E-31
UCS	TF	RPS6KB2	NAIF1	0.822882623	3.06E-31
UCS	TF	RPS6KB2	GTF3A	0.823636448	2.43E-31
UCS	TF	RPS6KB2	THYN1	0.824110137	2.10E-31
UCS	TF	RPS6KB2	IRF3	0.833155201	1.17E-32
UCS	TF	RPS6KB2	RBCK1	0.846108432	1.38E-34
UCS	TF	RPS6KB2	ZNF688	0.857812515	1.73E-36
UCS	TF	RPS6KB2	ZNF444	0.859183575	1.01E-36
UCS	TF	RPS6KB2	ZGPAT	0.863472282	1.81E-37
UCS	TF	RPS6KB2	MBD3	0.86561642	7.47E-38
UCS	TF	RPS6KB2	ZBTB17	0.870930037	7.82E-39
UCS	TF	RPS6KB2	ZNF668	0.871250894	6.80E-39
UCS	TF	RPS6KB2	PIN1	0.880282001	1.14E-40
UCS	TF	RPS6KB2	CXXC1	0.88924083	1.42E-42
UCS	TSG	RPS6KB2	GNB2L1	0.803016023	9.56E-29
UCS	TSG	RPS6KB2	BAX	0.80504639	5.48E-29
UCS	TSG	RPS6KB2	H2AFX	0.805091933	5.41E-29
UCS	TSG	RPS6KB2	HTRA2	0.806674169	3.49E-29
UCS	TSG	RPS6KB2	FZR1	0.8085488	2.07E-29
UCS	TSG	RPS6KB2	CYB561D2	0.809813628	1.45E-29
UCS	TSG	RPS6KB2	GLTSCR2	0.820024127	7.30E-31
UCS	TSG	RPS6KB2	IRF3	0.833155201	1.17E-32
UCS	TSG	RPS6KB2	SIRT6	0.837006294	3.27E-33
UCS	TSG	RPS6KB2	NPRL2	0.84306349	4.07E-34
UCS	TSG	RPS6KB2	ZNF668	0.871250894	6.80E-39
UCS	TSG	RPS6KB2	PFN1	0.871497802	6.11E-39
UCS	TSG	RPS6KB2	PIN1	0.880282001	1.14E-40
UCS	TSG	RPS6KB2	AIP	0.88641834	5.88E-42
UCS	TSG	RPS6KB2	TSSC4	0.898432233	1.04E-44
UCS	TSG	RPS6KB2	BRMS1	0.914921605	4.15E-49
UVM	TF	RPS6KB2	CAMTA2	0.802446809	3.61E-19
UVM	TSG	RPS6KB2	FZR1	0.812163274	6.16E-20

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRC	RPS6KB2	RPS6	-3.4556058277803	0.0001224322154943
PRAD	RPS6KB2	FOXA2	2.50903604660537	0.000123755256808017
HNSC	RPS6KB2	AKT3	-1.45403719490017	0.000371155359061959
PRAD	RPS6KB2	AKT2	1.0445197324651	0.00056691577859022
HNSC	RPS6KB2	AKT2	-6.40672767813808	0.00122944192639807
HNSC	RPS6KB2	FOXA2	-1.17665126019288	0.00149356685407406
THCA	RPS6KB2	RPS6	1.46346143665389	0.00305071956645465
CHOL	RPS6KB2	AKT2	-4.09728475517264	0.00390625
CHOL	RPS6KB2	RPTOR	-2.34317187916664	0.00390625
PRAD	RPS6KB2	PDPK1	1.81554957286714	0.00394734627371092
LIHC	RPS6KB2	PDPK1	-1.27273782890459	0.00401886677001472
COAD	RPS6KB2	AKT3	1.5912427129506	0.00427913665771485
LUAD	RPS6KB2	PDPK1	-2.39037258175029	0.00557540274754635
KIRP	RPS6KB2	RPS6	-1.15360907834159	0.0111397774890065
COAD	RPS6KB2	RPS6	1.03379589520851	0.011966735124588
BLCA	RPS6KB2	RPS6	-1.76940777579938	0.012359619140625
UCEC	RPS6KB2	IRS1	-2.15562069053176	0.015625
UCEC	RPS6KB2	PDPK1	1.79218384802367	0.015625
BLCA	RPS6KB2	PDPK1	1.31186516278878	0.0159721374511719
ESCA	RPS6KB2	PDPK1	-1.08809436254042	0.0244140625
LUAD	RPS6KB2	AKT1	-4.53714460696341	0.0301695351050489
THCA	RPS6KB2	FOXA2	-3.22526720433536	1.83841618870772e-10
BRCA	RPS6KB2	IRS1	-1.3249458760778	2.02139514341716e-15
BRCA	RPS6KB2	EIF4B	-2.16032742029696	2.35556737304054e-22
KICH	RPS6KB2	FOXA2	2.54394933968532	2.50569922986382e-05
THCA	RPS6KB2	IRS1	-1.72997935219705	3.82403518090519e-10
HNSC	RPS6KB2	IRS1	2.20124565101457	3.84812503853028e-05
KIRC	RPS6KB2	PDPK1	-1.27456564339616	4.74133731393022e-07
BRCA	RPS6KB2	AKT3	-2.30730283027678	5.26435708486194e-13
LUSC	RPS6KB2	FOXA2	-2.40062545500928	5.97174133915752e-10
LIHC	RPS6KB2	RPTOR	-4.36362270436135	6.64579404273587e-07
KICH	RPS6KB2	PDPK1	1.47618241053961	7.49826431274414e-05
LIHC	RPS6KB2	AKT2	-1.28319262096228	7.56292418171002e-05
KIRC	RPS6KB2	EIF4B	1.14997140510474	7.59366366705366e-09
PRAD	RPS6KB2	MTOR	2.45767376269894	8.16442831201447e-07

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPS6KB2

BTK, LYN, SRC, SYK, IKBKG, KAT2B, EP300, MAPK8IP2, NEDD4L, STRBP, PRKCE, BRAF, FBXO25, CSNK2B, ATP5A1, SRPK1, MOV10, NXF1, ACPP, ACTA1, ACTG1, AIFM1, ALB, ALG1, ANKMY2, ANXA2, ATP1A1, BAG2, RTCB, CAD, CAPRIN1, CAPZA1, CCDC124, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT7, CCT8, CDC37, CDC45, CFL1, CLNS1A, DDB1, DDX1, DDX17, DDX3X, DDX5, DDX6, DHX9, DNAJA2, DNAJB1, DNAJC7, DNAJA1, EEF1A1, EEF1G, EIF2S2, EIF3B, EWSR1, FAM60A, FKBP5, FKBP8, FUS, G3BP1, GDF5, GTF2I, HAT1, LRRC15, HLA-A, HNRNPA1, HNRNPA2B1, HNRNPK, HNRNPM, HNRNPU, HSP90AA1, HSP90AB1, HSPA14, HSPA1A, HSPA4L, HSPA5, HSPA6, HSPA8, HSPA9, HSPD1, HSPH1, IGF2BP1, IPO5, IPO7, IQGAP1, KIF2A, KIF5B, KRT1, KRT10, KRT13, KRT14, KRT16, KRT2, KRT5, KRT6A, KRT9, LRPPRC, LTV1, LYZ, MAGED1, MAGED2, MCM3, MRPS22, MSH6, MYO1C, NCL, NME3, NONO, NPM1, NUDC, PCBP1, PCMT1, PCNA, PDCD4, PHGDH, POLDIP3, PPM1G, PPP2CA, PPP2R1A, PPP2R2A, PPP6R1, PPP6R3, NPY4R, PRDX1, PRMT1, PRSS3, PSMC1, PSMC2, PSMC3, PSMD3, PSPC1, PTGES3, RBBP7, RPL13, RPL14, RPL17, RPL19, RPL22L1, RPL23A, RPL24, RPL26, RPL8, RPN1, RPS14, RPS17, RPS18, RPS19, RPS2, RPS25, RPS3, RPS3A, RPS4X, RPS5, RPS6, RPS7, RPS8, RUVBL1, RUVBL2, SERBP1, SFPQ, SHROOM3, SLC25A5, SLC3A2, SNRPB, SSR1, STUB1, SUGT1, TAF15, TCP1, TFAM, TIMM50, TUBA1B, TUBA1C, TUBB, TUBB4B, TUBB3, TUBB6, TUFM, USP7, USP9X, WBSCR22, WRNIP1, XRCC5, YBX1, YTHDF2, YWHAH, YWHAQ, SNRPE, LRRK2, ESR2, RPL7A, RPLP0, RPL6, RPL12, ZC3HAV1, RPL3, ASPH, DDX21, PABPC1, EIF2S3, RPL9, RPL10A, PPM1B, ZNF90, RPLP2, RPL18, SRSF2, RPS15A, RPS13, RPL32, RPL30, RPL27, RPL7, RPL11, RPL10, RPS24, RPS26, RPL21, RPL4, FYN, PDGFRB, CCDC47, HSP90AA5P, CEP76, MTOR,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPS6KB2	BRCA	chr11	67202156	67202156	C	T	Missense_Mutation	p.A420V	5
RPS6KB2	BRCA	chr11	67202530	67202530	C	G	Missense_Mutation	p.L447V	4
RPS6KB2	COAD	chr11	67200475	67200475	C	T	Silent	p.G223G	4
RPS6KB2	UCEC	chr11	67202510	67202510	C	T	Missense_Mutation	p.P440L	3
RPS6KB2	UCEC	chr11	67201718	67201718	G	A	Missense_Mutation	p.R340H	3
RPS6KB2	SKCM	chr11	67201482	67201482	C	T	Missense_Mutation	p.P308L	3
RPS6KB2	PAAD	chr11	67196455	67196455	C	T	Silent	p.D27D	3
RPS6KB2	BRCA	chr11	67200919	67200919	G	T	Splice_Site	e10+1	3
RPS6KB2	LIHC	chr11	67200629	67200629	A	G	Missense_Mutation	p.N247S	2
RPS6KB2	STAD	chr11	67201943	67201943	C	T	Silent	p.N381N	2
RPS6KB2	HNSC	chr11	67200087	67200087	G	A	Silent	p.T158T	2
RPS6KB2	STAD	chr11	67201901	67201901	G	A	Silent	p.P367P	2
RPS6KB2	MESO	chr11	67201956	67201956	G	A	Splice_Site		2
RPS6KB2	HNSC	chr11	67200832	67200832	C	T	Missense_Mutation	p.R274W	2
RPS6KB2	STAD	chr11	67200863	67200863	G	T	Missense_Mutation	p.G284V	2
RPS6KB2	STAD	chr11	67201891	67201891	G	A	Missense_Mutation	p.R364Q	2
RPS6KB2	PAAD	chr11	67196455	67196455	C	T	Silent		2
RPS6KB2	UCEC	chr11	67200130	67200130	T	C	Splice_Site	e6+2	2
RPS6KB2	SKCM	chr11	67200847	67200847	G	A	Missense_Mutation	p.D279N	2
RPS6KB2	PAAD	chr11	67200475	67200475	C	T	Silent		2
RPS6KB2	UCEC	chr11	67200453	67200453	G	A	Missense_Mutation	p.C216Y	2
RPS6KB2	BRCA	chr11	67196636	67196636	G	A	Silent	p.V55	2
RPS6KB2	LIHC	chr11	67202460	67202460	C	-	Splice_Site	p.S423_splice	2
RPS6KB2	PAAD	chr11	67200423	67200423	G	A	Missense_Mutation		2
RPS6KB2	UCEC	chr11	67201701	67201701	C	T	Silent	p.D334	2
RPS6KB2	BRCA	chr11	67200221	67200221	G	A	Missense_Mutation	p.E177K	2
RPS6KB2	SKCM	chr11	67200855	67200855	C	T	Silent	p.I281I	2
RPS6KB2	BRCA	chr11	67202569	67202569	G	A	Missense_Mutation	p.A460T	2
RPS6KB2	LIHC	chr11	67200629	67200629	A	G	Missense_Mutation		2
RPS6KB2	UCEC	chr11	67202553	67202553	G	A	Silent	p.P454	2
RPS6KB2	STAD	chr11	67200122	67200122	C	T	Missense_Mutation		2
RPS6KB2	STAD	chr11	67200122	67200122	C	T	Missense_Mutation	p.T170M	2
RPS6KB2	THYM	chr11	67202499	67202499	C	T	Silent	p.S436S	1
RPS6KB2	BLCA	chr11	67198961	67198961	C	G	Silent	p.L144L	1
RPS6KB2	HNSC	chr11	67196593	67196593	C	T	Missense_Mutation	p.P41L	1
RPS6KB2	PRAD	chr11	67198879	67198879	G	A	Missense_Mutation	p.R117Q	1
RPS6KB2	COAD	chr11	67201897	67201897	C	T	Missense_Mutation	p.T366M	1
RPS6KB2	LUSC	chr11	67202553	67202553	G	T	Silent	p.P454P	1
RPS6KB2	BLCA	chr11	67200436	67200436	G	C	Silent	p.L210L	1
RPS6KB2	CESC	chr11	67202156	67202156	C	T	Missense_Mutation		1
RPS6KB2	LIHC	chr11	67200122	67200122	C	A	Missense_Mutation	p.T170K	1
RPS6KB2	PRAD	chr11	67196653	67196653	G	A	Missense_Mutation	p.R61H	1
RPS6KB2	ESCA	chr11	67202559	67202559	C	A	Silent	p.P456	1
RPS6KB2	UCEC	chr11	67201701	67201701	C	T	Silent	p.D334D	1
RPS6KB2	BLCA	chr11	67200265	67200265	C	G	Missense_Mutation	p.I191M	1
RPS6KB2	CESC	chr11	67196398	67196398	G	T	Silent		1
RPS6KB2	LIHC	chr11	67200877	67200877	C	-	Frame_Shift_Del	p.P290fs	1
RPS6KB2	SARC	chr11	67200096	67200096	G	T	Missense_Mutation		1
RPS6KB2	ESCA	chr11	67202559	67202559	C	A	Silent	p.P456P	1
RPS6KB2	OV	chr11	67200504	67200504	T	C	Missense_Mutation	p.I233T	1
RPS6KB2	BLCA	chr11	67202103	67202103	C	T	Silent	p.F402F	1
RPS6KB2	KIRP	chr11	67201948	67201948	C	G	Missense_Mutation	p.A383G	1
RPS6KB2	CESC	chr11	67200086	67200086	C	C	Missense_Mutation		1
RPS6KB2	LIHC	chr11	67202541	67202541	C	-	Frame_Shift_Del	p.L451fs	1
RPS6KB2	SARC	chr11	67202054	67202054	G	T	Missense_Mutation		1
RPS6KB2	ESCA	chr11	67202511	67202511	G	T	Silent	p.P440P	1
RPS6KB2	BLCA	chr11	67200837	67200837	G	A	Silent	p.K275K	1
RPS6KB2	LGG	chr11	67198887	67198887	C	T	Missense_Mutation	p.R120W	1
RPS6KB2	CESC	chr11	67200648	67200648	G	A	Nonsense_Mutation	p.W253*	1
RPS6KB2	LIHC	chr11	67202148	67202148	C	-	Frame_Shift_Del	p.S417fs	1
RPS6KB2	STAD	chr11	67200454	67200454	C	T	Silent	p.C216C	1
RPS6KB2	HNSC	chr11	67201697	67201697	G	T	Missense_Mutation		1
RPS6KB2	LGG	chr11	67200096	67200096	G	T	Missense_Mutation	p.E161D	1
RPS6KB2	CESC	chr11	67200801	67200801	C	A	RNA	NULL	1
RPS6KB2	STAD	chr11	67201739	67201739	C	A	Missense_Mutation	p.P347H	1
RPS6KB2	HNSC	chr11	67200812	67200812	C	T	Missense_Mutation		1
RPS6KB2	LIHC	chr11	67196051	67196051	A	G	Missense_Mutation		1
RPS6KB2	CESC	chr11	67202296	67202296	C	T	RNA	NULL	1
RPS6KB2	LUAD	chr11	67200239	67200239	G	T	Missense_Mutation	p.G183C	1
RPS6KB2	STAD	chr11	67196696	67196696	G	-	Frame_Shift_Del	p.K75fs	1
RPS6KB2	HNSC	chr11	67200087	67200087	G	A	Missense_Mutation		1
RPS6KB2	PAAD	chr11	67202460	67202460	C	-	Splice_Site	.	1
RPS6KB2	CESC	chr11	67202364	67202364	C	A	RNA	NULL	1
RPS6KB2	LUAD	chr11	67200238	67200238	G	T	Silent	p.L182L	1
RPS6KB2	SKCM	chr11	67200124	67200124	G	A	Missense_Mutation	p.A171T	1
RPS6KB2	TGCT	chr11	67200819	67200819	C	T	Silent		1
RPS6KB2	HNSC	chr11	67200832	67200832	C	T	Missense_Mutation		1
RPS6KB2	LIHC	chr11	67198912	67198912	A	G	Missense_Mutation		1
RPS6KB2	PAAD	chr11	67200423	67200423	G	A	Splice_Site	p.G206_splice	1
RPS6KB2	COAD	chr11	67198855	67198855	A	G	Missense_Mutation	p.N109S	1
RPS6KB2	LUAD	chr11	67198888	67198888	G	T	Missense_Mutation	p.R120L	1
RPS6KB2	SKCM	chr11	67198944	67198944	C	T	Nonsense_Mutation	p.Q139*	1
RPS6KB2	THCA	chr11	67201890	67201890	C	T	Missense_Mutation		1
RPS6KB2	BLCA	chr11	67198961	67198961	C	G	Silent		1
RPS6KB2	HNSC	chr11	67200901	67200901	C	A	Silent		1
RPS6KB2	LIHC	chr11	67200857	67200857	T	C	Missense_Mutation	p.I282T	1
RPS6KB2	PAAD	chr11	67200423	67200423	G	A	Splice_Site	p.G206D	1
RPS6KB2	LUAD	chr11	67200617	67200617	G	T	Missense_Mutation	p.R243L	1
RPS6KB2	THCA	chr11	67201890	67201890	C	T	Missense_Mutation	p.R364W	1
RPS6KB2	BLCA	chr11	67200837	67200837	G	A	Silent		1
RPS6KB2	HNSC	chr11	67196593	67196593	C	T	Missense_Mutation		1
RPS6KB2	BRCA	chr11	67196544	67196544	C	G	Missense_Mutation	p.L15V	1
RPS6KB2	LIHC	chr11	67200655	67200655	G	A	Missense_Mutation	p.G256R	1
RPS6KB2	PRAD	chr11	67201898	67201898	G	A	Silent	p.T366T	1
RPS6KB2	COAD	chr11	67200819	67200819	C	T	Silent	p.F269F	1
RPS6KB2	LUSC	chr11	67201893	67201893	C	T	Nonsense_Mutation	p.Q365*	1

Copy number variation (CNV) of RPS6KB2
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPS6KB2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
73064	BRCA	TCGA-AR-A1AY	KDM2A	chr11	66888829	+	RPS6KB2	chr11	67200810	+
73064	BRCA	TCGA-AR-A1AY-01A	KDM2A	chr11	66888828	+	RPS6KB2	chr11	67200810	+
73064	BRCA	TCGA-AR-A1AY-01A	KDM2A	chr11	66888829	+	RPS6KB2	chr11	67200811	+
73064	BRCA	TCGA-AR-A1AY-01A	KDM2A	chr11	66917286	+	RPS6KB2	chr11	67200811	+
73066	LIHC	TCGA-DD-AADG	RBP4	chr10	95360147	-	RPS6KB2	chr11	67200673	+
86768	BRCA	TCGA-A2-A0CL-01A	RPS6KB2	chr11	67196094	+	C10orf54	chr10	73515223	-
96250	BRCA	TCGA-AN-A03Y-01A	RPS6KB2	chr11	67196711	+	PAAF1	chr11	73627590	+
78053	HNSC	TCGA-F7-7848	RPS6KB2	chr11	67196711	+	PCNXL3	chr11	65385410	+
78053	HNSC	TCGA-F7-7848	RPS6KB2	chr11	67196711	+	PCNXL3	chr11	65385411	+
78053	BLCA	TCGA-DK-A6AV-01A	RPS6KB2	chr11	67197066	+	ST3GAL2	chr16	70422449	-
78053	BRCA	TCGA-AN-A0XW-01A	RPS6KB2	chr11	67196094	+	SYNE4	chr19	36496339	-
78053	N/A	KF857249	RPS6KB2	chr11	67198154	-	SYT12	chr11	66803176	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
HNSC	RPS6KB2	0.00298406291844717	0.084
TGCT	RPS6KB2	0.0133612166265638	0.36
BRCA	RPS6KB2	0.0300902173939163	0.78

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUAD	RPS6KB2	1.71634461645609e-05	0.00057
BRCA	RPS6KB2	0.033299712723074	0.9
PAAD	RPS6KB2	0.0171422753349647	0.53
CESC	RPS6KB2	0.0256403526422988	0.72
ACC	RPS6KB2	0.023843536961698	0.69
THYM	RPS6KB2	0.0230132315100046	0.69
SARC	RPS6KB2	0.0118775639899023	0.38

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0006142	Malignant neoplasm of breast	1	CTD_human
C0678222	Breast Carcinoma	1	CTD_human
C1257931	Mammary Neoplasms, Human	1	CTD_human
C4704874	Mammary Carcinoma, Human	1	CTD_human