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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPS14 (NCBI Gene ID:6208)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPS14
	Gene ID: 6208
	Gene Symbol	RPS14
	Gene ID	6208
	Gene Name	ribosomal protein S14
	Synonyms	EMTB\|S14
	Cytomap	5q33.1
	Type of Gene	protein-coding
	Description	40S ribosomal protein S14emetine resistancesmall ribosomal subunit protein uS11
	Modification date	20200313
	UniProtAcc	P62263

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPS14	GO:0000122	negative regulation of transcription by RNA polymerase II	7867928

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPS14	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPS14[title] AND translation [title] AND human.'

Gene	Title	PMID
RPS14	Integrated analyses of translatome and proteome identify the rules of translation selectivity in RPS14-deficient cells	32327500

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KIRP	RPS14	-1.10710481020121	0.00114433001726866
THCA	RPS14	1.18855682463527	0.0484049760061147

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
HNSC	RPS14	1	2	0.0382181799942628	0.181864817927171	0.216873538461538	0.101728852830054	0.00381763714386424
UVM	RPS14	1	2	0.0126154604073817	0.184651948051948	0.216613793103448	-0.623623999221273	0.028451706108069

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
PCPG	RPS14	0.076385995	0.018723248

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPS14 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
ACC	TSG	RPS14	GNB2L1	0.850745978	3.27E-23
BLCA	TSG	RPS14	GNB2L1	0.895120595	7.61E-151
BRCA	TSG	RPS14	GNB2L1	0.828188812	4.58E-308
CESC	TSG	RPS14	GNB2L1	0.890090344	1.95E-106
CHOL	Cell metabolism gene	RPS14	PFDN5	0.807990775	1.96E-11
CHOL	CGC	RPS14	NACA	0.879571893	1.83E-15
CHOL	Epifactor	RPS14	FBL	0.805858513	2.42E-11
CHOL	TSG	RPS14	GNB2L1	0.925280013	1.02E-19
COAD	TSG	RPS14	GNB2L1	0.857398528	2.38E-96
DLBC	Cell metabolism gene	RPS14	GFER	0.806769767	4.42E-12
DLBC	Cell metabolism gene	RPS14	PGLS	0.82484826	5.68E-13
DLBC	Cell metabolism gene	RPS14	TOMM22	0.827972863	3.89E-13
DLBC	Cell metabolism gene	RPS14	GEMIN7	0.83610218	1.40E-13
DLBC	Cell metabolism gene	RPS14	TIMM9	0.843599326	5.20E-14
DLBC	Cell metabolism gene	RPS14	FAU	0.845373474	4.08E-14
DLBC	Cell metabolism gene	RPS14	PFDN5	0.855481606	9.67E-15
DLBC	Cell metabolism gene	RPS14	SNRPD2	0.855795814	9.23E-15
DLBC	Cell metabolism gene	RPS14	NME2	0.859228201	5.51E-15
DLBC	CGC	RPS14	NACA	0.879038103	2.10E-16
DLBC	Epifactor	RPS14	FBL	0.806471272	4.56E-12
DLBC	TF	RPS14	ZNF581	0.818470458	1.20E-12
DLBC	TF	RPS14	NME2	0.859228201	5.51E-15
DLBC	TSG	RPS14	GADD45GIP1	0.812810112	2.28E-12
DLBC	TSG	RPS14	HINT1	0.828016941	3.87E-13
DLBC	TSG	RPS14	GLTSCR2	0.833753345	1.89E-13
DLBC	TSG	RPS14	GNB2L1	0.945064818	5.67E-24
GBM	Cell metabolism gene	RPS14	ZNRD1	0.801362935	8.75E-40
GBM	Cell metabolism gene	RPS14	LSM1	0.809968025	3.01E-41
GBM	Cell metabolism gene	RPS14	TIMM8B	0.81317546	8.20E-42
GBM	Cell metabolism gene	RPS14	PIGC	0.814574567	4.61E-42
GBM	Cell metabolism gene	RPS14	PSMB3	0.814595046	4.58E-42
GBM	Cell metabolism gene	RPS14	SSR2	0.820125292	4.49E-43
GBM	Cell metabolism gene	RPS14	LSM2	0.821360787	2.64E-43
GBM	Cell metabolism gene	RPS14	PSMB4	0.823781124	9.25E-44
GBM	Cell metabolism gene	RPS14	PSMA5	0.824219881	7.64E-44
GBM	Cell metabolism gene	RPS14	SSR4	0.8297281	6.55E-45
GBM	Cell metabolism gene	RPS14	FAU	0.846518733	2.05E-48
GBM	Cell metabolism gene	RPS14	SNRPD2	0.852074012	1.15E-49
GBM	Cell metabolism gene	RPS14	PFDN5	0.86822012	1.27E-53
GBM	Cell metabolism gene	RPS14	SNRPG	0.873031898	6.68E-55
GBM	Epifactor	RPS14	DPY30	0.815293895	3.43E-42
GBM	TF	RPS14	GTF2B	0.809594601	3.50E-41
HNSC	TSG	RPS14	GNB2L1	0.883309045	1.03E-187
KICH	Cell metabolism gene	RPS14	TBCA	0.811946609	1.61E-22
KICH	TSG	RPS14	GNB2L1	0.890290312	3.73E-32
KIRP	Cell metabolism gene	RPS14	FAU	0.806687098	2.60E-75
KIRP	Cell metabolism gene	RPS14	SNRPD2	0.813465745	1.53E-77
KIRP	TSG	RPS14	GNB2L1	0.873825215	1.53E-102
LGG	Cell metabolism gene	RPS14	FAU	0.855074061	9.96E-153
LGG	TSG	RPS14	GNB2L1	0.827651923	1.49E-134
LIHC	TSG	RPS14	GNB2L1	0.884650031	1.36E-141
MESO	TSG	RPS14	GNB2L1	0.930076997	1.00E-38
OV	TSG	RPS14	GNB2L1	0.810008307	6.62E-73
PAAD	TSG	RPS14	GNB2L1	0.872783262	2.83E-58
PCPG	Epifactor	RPS14	FBL	0.813593106	1.94E-45
PCPG	TSG	RPS14	GNB2L1	0.90552909	8.45E-71
PRAD	Cell metabolism gene	RPS14	NME2	0.815931975	1.65E-132
PRAD	Cell metabolism gene	RPS14	TIMM9	0.821550828	7.82E-136
PRAD	Cell metabolism gene	RPS14	SNRPD2	0.852190575	2.79E-156
PRAD	Cell metabolism gene	RPS14	FAU	0.855655131	6.98E-159
PRAD	CGC	RPS14	NACA	0.856739963	1.04E-159
PRAD	Epifactor	RPS14	FBL	0.882439216	1.29E-181
PRAD	TF	RPS14	NME2	0.815931975	1.65E-132
PRAD	TSG	RPS14	GNB2L1	0.895914651	2.93E-195
READ	TSG	RPS14	GNB2L1	0.837394781	8.91E-29
SKCM	TSG	RPS14	GNB2L1	0.870955791	9.24E-148
TGCT	Epifactor	RPS14	FBL	0.817320004	1.05E-38
TGCT	TSG	RPS14	GNB2L1	0.887161789	1.37E-53
THCA	Cell metabolism gene	RPS14	PFDN5	0.822736683	5.90E-142
THCA	Cell metabolism gene	RPS14	FAU	0.853976256	7.29E-164
THCA	Cell metabolism gene	RPS14	SNRPD2	0.869829751	4.83E-177
THCA	Epifactor	RPS14	FBL	0.838342634	2.58E-152
THCA	TSG	RPS14	GNB2L1	0.834107901	2.13E-149
THYM	Cell metabolism gene	RPS14	POLR2J	0.8009647	1.67E-28
THYM	Cell metabolism gene	RPS14	EXOSC4	0.801085349	1.61E-28
THYM	Cell metabolism gene	RPS14	SNRPD3	0.802140022	1.21E-28
THYM	Cell metabolism gene	RPS14	POLR2H	0.806570164	3.59E-29
THYM	Cell metabolism gene	RPS14	DPM3	0.807963609	2.44E-29
THYM	Cell metabolism gene	RPS14	APRT	0.809005749	1.82E-29
THYM	Cell metabolism gene	RPS14	IMPDH2	0.817231224	1.68E-30
THYM	Cell metabolism gene	RPS14	TIMM50	0.820420154	6.48E-31
THYM	Cell metabolism gene	RPS14	PSMB7	0.824063338	2.13E-31
THYM	Cell metabolism gene	RPS14	TIMM8B	0.82862294	5.08E-32
THYM	Cell metabolism gene	RPS14	LCMT1	0.833535353	1.04E-32
THYM	Cell metabolism gene	RPS14	GFER	0.837064787	3.20E-33
THYM	Cell metabolism gene	RPS14	TIMM13	0.842498562	4.97E-34
THYM	Cell metabolism gene	RPS14	TOMM7	0.844891049	2.14E-34
THYM	Cell metabolism gene	RPS14	POLR2I	0.853101742	1.06E-35
THYM	Cell metabolism gene	RPS14	POLR2F	0.853273457	9.91E-36
THYM	Cell metabolism gene	RPS14	SLC27A5	0.857993354	1.61E-36
THYM	Cell metabolism gene	RPS14	SNRPD2	0.860583698	5.80E-37
THYM	Cell metabolism gene	RPS14	PGLS	0.864357157	1.26E-37
THYM	Cell metabolism gene	RPS14	DPM2	0.883993193	1.94E-41
THYM	Cell metabolism gene	RPS14	SSR2	0.888517751	2.05E-42
THYM	Cell metabolism gene	RPS14	PFDN5	0.900502077	3.21E-45
THYM	Cell metabolism gene	RPS14	FAU	0.90607359	1.20E-46
THYM	CGC	RPS14	RBM10	0.811191471	9.76E-30
THYM	Epifactor	RPS14	EXOSC4	0.801085349	1.61E-28
THYM	Epifactor	RPS14	C17orf49	0.80544487	4.91E-29
THYM	Epifactor	RPS14	TAF10	0.818708639	1.08E-30
THYM	Epifactor	RPS14	BRMS1	0.819443779	8.69E-31
THYM	Epifactor	RPS14	ZNHIT1	0.823008011	2.94E-31
THYM	Epifactor	RPS14	SIRT6	0.826008749	1.16E-31
THYM	Epifactor	RPS14	PRPF31	0.842564986	4.85E-34
THYM	Epifactor	RPS14	FBL	0.907167041	6.14E-47
THYM	IUPHAR	RPS14	SIRT3	0.811693081	8.46E-30
THYM	IUPHAR	RPS14	IMPDH2	0.817231224	1.68E-30
THYM	IUPHAR	RPS14	SIRT6	0.826008749	1.16E-31
THYM	IUPHAR	RPS14	SLC27A5	0.857993354	1.61E-36
THYM	TF	RPS14	ZNF32	0.810303746	1.26E-29
THYM	TF	RPS14	REXO4	0.812962466	5.87E-30
THYM	TF	RPS14	ZNF428	0.819355831	8.93E-31
THYM	TF	RPS14	THAP3	0.830182784	3.08E-32
THYM	TF	RPS14	ZNF787	0.833079158	1.20E-32
THYM	TF	RPS14	ZNF524	0.833424301	1.08E-32
THYM	TF	RPS14	THAP7	0.834129641	8.52E-33
THYM	TF	RPS14	ZNF581	0.844272304	2.66E-34
THYM	TSG	RPS14	GABARAP	0.804726003	5.99E-29
THYM	TSG	RPS14	SIRT3	0.811693081	8.46E-30
THYM	TSG	RPS14	BRMS1	0.819443779	8.69E-31
THYM	TSG	RPS14	SIRT6	0.826008749	1.16E-31
THYM	TSG	RPS14	GLTSCR2	0.834166666	8.42E-33
THYM	TSG	RPS14	GADD45GIP1	0.845841713	1.52E-34
THYM	TSG	RPS14	TSSC4	0.845930753	1.47E-34
THYM	TSG	RPS14	GNB2L1	0.886363813	6.04E-42
UCEC	TSG	RPS14	GNB2L1	0.883825044	1.41E-67
UCS	Cell metabolism gene	RPS14	POLR2J	0.8009647	1.67E-28
UCS	Cell metabolism gene	RPS14	EXOSC4	0.801085349	1.61E-28
UCS	Cell metabolism gene	RPS14	SNRPD3	0.802140022	1.21E-28
UCS	Cell metabolism gene	RPS14	POLR2H	0.806570164	3.59E-29
UCS	Cell metabolism gene	RPS14	DPM3	0.807963609	2.44E-29
UCS	Cell metabolism gene	RPS14	APRT	0.809005749	1.82E-29
UCS	Cell metabolism gene	RPS14	IMPDH2	0.817231224	1.68E-30
UCS	Cell metabolism gene	RPS14	TIMM50	0.820420154	6.48E-31
UCS	Cell metabolism gene	RPS14	PSMB7	0.824063338	2.13E-31
UCS	Cell metabolism gene	RPS14	TIMM8B	0.82862294	5.08E-32
UCS	Cell metabolism gene	RPS14	LCMT1	0.833535353	1.04E-32
UCS	Cell metabolism gene	RPS14	GFER	0.837064787	3.20E-33
UCS	Cell metabolism gene	RPS14	TIMM13	0.842498562	4.97E-34
UCS	Cell metabolism gene	RPS14	TOMM7	0.844891049	2.14E-34
UCS	Cell metabolism gene	RPS14	POLR2I	0.853101742	1.06E-35
UCS	Cell metabolism gene	RPS14	POLR2F	0.853273457	9.91E-36
UCS	Cell metabolism gene	RPS14	SLC27A5	0.857993354	1.61E-36
UCS	Cell metabolism gene	RPS14	SNRPD2	0.860583698	5.80E-37
UCS	Cell metabolism gene	RPS14	PGLS	0.864357157	1.26E-37
UCS	Cell metabolism gene	RPS14	DPM2	0.883993193	1.94E-41
UCS	Cell metabolism gene	RPS14	SSR2	0.888517751	2.05E-42
UCS	Cell metabolism gene	RPS14	PFDN5	0.900502077	3.21E-45
UCS	Cell metabolism gene	RPS14	FAU	0.90607359	1.20E-46
UCS	CGC	RPS14	RBM10	0.811191471	9.76E-30
UCS	Epifactor	RPS14	EXOSC4	0.801085349	1.61E-28
UCS	Epifactor	RPS14	C17orf49	0.80544487	4.91E-29
UCS	Epifactor	RPS14	TAF10	0.818708639	1.08E-30
UCS	Epifactor	RPS14	BRMS1	0.819443779	8.69E-31
UCS	Epifactor	RPS14	ZNHIT1	0.823008011	2.94E-31
UCS	Epifactor	RPS14	SIRT6	0.826008749	1.16E-31
UCS	Epifactor	RPS14	PRPF31	0.842564986	4.85E-34
UCS	Epifactor	RPS14	FBL	0.907167041	6.14E-47
UCS	IUPHAR	RPS14	SIRT3	0.811693081	8.46E-30
UCS	IUPHAR	RPS14	IMPDH2	0.817231224	1.68E-30
UCS	IUPHAR	RPS14	SIRT6	0.826008749	1.16E-31
UCS	IUPHAR	RPS14	SLC27A5	0.857993354	1.61E-36
UCS	TF	RPS14	ZNF32	0.810303746	1.26E-29
UCS	TF	RPS14	REXO4	0.812962466	5.87E-30
UCS	TF	RPS14	ZNF428	0.819355831	8.93E-31
UCS	TF	RPS14	THAP3	0.830182784	3.08E-32
UCS	TF	RPS14	ZNF787	0.833079158	1.20E-32
UCS	TF	RPS14	ZNF524	0.833424301	1.08E-32
UCS	TF	RPS14	THAP7	0.834129641	8.52E-33
UCS	TF	RPS14	ZNF581	0.844272304	2.66E-34
UCS	TSG	RPS14	GABARAP	0.804726003	5.99E-29
UCS	TSG	RPS14	SIRT3	0.811693081	8.46E-30
UCS	TSG	RPS14	BRMS1	0.819443779	8.69E-31
UCS	TSG	RPS14	SIRT6	0.826008749	1.16E-31
UCS	TSG	RPS14	GLTSCR2	0.834166666	8.42E-33
UCS	TSG	RPS14	GADD45GIP1	0.845841713	1.52E-34
UCS	TSG	RPS14	TSSC4	0.845930753	1.47E-34
UCS	TSG	RPS14	GNB2L1	0.886363813	6.04E-42
UVM	Cell metabolism gene	RPS14	POLR1D	0.803218534	3.15E-19
UVM	Cell metabolism gene	RPS14	TOMM7	0.80435259	2.57E-19
UVM	Cell metabolism gene	RPS14	FAU	0.848945522	2.63E-23
UVM	CGC	RPS14	NACA	0.860295841	1.57E-24
UVM	Epifactor	RPS14	FBL	0.840186541	1.99E-22
UVM	TF	RPS14	ZNF581	0.803207477	3.15E-19
UVM	TSG	RPS14	GAS5	0.815968103	2.99E-20
UVM	TSG	RPS14	GLTSCR2	0.845341314	6.14E-23
UVM	TSG	RPS14	GNB2L1	0.912386167	5.43E-32

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPS14	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPS14	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPS14	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPS14	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPS14	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPS14	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPS14	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPS14	RPL19	1.36901182894089	0.00250792503356934
KICH	RPS14	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPS14	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPS14	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPS14	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPS14	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPS14	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPS14	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPS14	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPS14	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPS14	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPS14	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPS14	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPS14	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPS14	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPS14	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPS14	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPS14	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPS14	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPS14	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPS14	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPS14

TAF9, MAGEB2, RIPK2, TRIP6, NELFCD, RBBP6, MEPCE, Mapk13, CALM1, EBNA-LP, VHL, RAD21, MDM2, SIRT7, CUL3, CUL4A, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, CAND1, RPS4X, APP, RPL11, RPL15, RPL18, RPL19, RPL30, RPL31, RPL37A, RPL4, RPL6, RPL7, RPL9, RPS11, RPS13, RPS15A, RPS23, RPS24, RPS2, RPS6, RPS7, RPS8, RPL23, RPS3, RPL5, RPS5, RPS10, RPL18A, RPL23A, RPLP2, RPSA, RPS19, RPLP0, RPS16, RPS25, RPL7A, RPS15, RPS9, RPS26, RPS3A, RPS29, EEF1A1, NOLC1, MYBBP1A, FBL, NOP58, U2AF1, NHP2L1, HNRNPM, TOP1, ILF3, HNRNPU, DHX9, GNL3, RPLP0P6, NCSTN, PRPF8, RANBP2, RBM39, RPL10L, HIST1H2AA, HP1BP3, ESR1, SENP8, SMURF1, FN1, VCAM1, SMAD2, UBL4A, ITGA4, PAN2, CD81, IGSF8, ICAM1, PEX6, RLIM, TMEM33, TARDBP, PARK2, LARP1, RPS12, RPS18, RPS20, RPS27, RPS28, WIBG, SERBP1, TSR1, ZBTB1, AURKA, CEP250, CEP57, CEP76, TP53, TUBG1, TUBGCP3, HUWE1, FUS, CUL7, CCDC8, EED, RPS6KB2, HNRNPUL2, NDUFS4, RPL10A, RPL12, RPL17, RPL27A, RPL28, AK3, GGPS1, MRPL15, MRPL3, RPL10, RPL13, RPL13A, RPL14, RPL21, RPL22, RPL24, RPL26, RPL27, RPL3, RPL34, RPL35, RPL35A, RPL36, RPL38, RPL8, RPLP1, LOC101929876, SEC61A1, UBA52, BLM, XPO1, HIST1H3E, AHSA1, NPM1, NOP56, CENPQ, CBX8, Cbx1, Eif3a, Eif3e, Rpl35, Srp72, Rrbp1, Fbxo21, TP73, CRY1, CRY2, MCM2, Ksr1, Mdm2, ESRRB, RC3H1, PCMTD1, NOB1, FRMD8, CENPV, RRP12, ZNF430, RBM19, CCZ1, TAF1D, SDAD1, CEBPZ, TAF1C, KRR1, RPL26L1, NAT10, NOC4L, RPL36AL, KRI1, NOC2L, RRS1, BMS1, YTHDC2, DDX18, LTV1, ZNF121, PDCD11, PPAN-P2RY11, RBM28, NGDN, PRKRIR, BUD13, REXO4, DDX31, CCDC137, STAU1, NOP14, PRPF4B, DDX24, DCAF5, RPL32, CDK12, KIAA0020, NKTR, RRP8, SPTY2D1, ZNF574, SRPK1, TTF1, RPF2, DDX54, NSA2, GTPBP4, RBM42, RBMX2, ZBTB24, DHX57, CCDC59, DHX30, L3HYPDH, NOP9, NCL, CYLD, TRIM25, HEY1, BRCA1, ACO2, APOE, WDR77, CTNNB1, IQGAP1, TRIP4, CCNT1, HDAC4, KRAS, MATN2, PCBP1, YAP1, UBE2M, EFTUD2, AAR2, PIH1D1, TNIP2, CHD3, CHD4, RNF31, CDC34, SPDL1, RIOK1, HEXIM1, LARP7, RNF123, SNAI1, AGR2, RECQL4, DCPS, REST, MYC, Prkaa1, Prkab1, AURKAIP1, METTL3, METTL14, KIAA1429, EIF4B, RC3H2, ZBTB7A, PHB, USP14, NR2C2, PPP1CC, CTCF, ATXN3, VRK1, VRK3, HIST1H4A, SNRNP70, ITFG1, ARAF, HMGB1, PPP1CA, BIRC3, NFX1, WWP2, SOX2, TRIM28, ARIH2, PINK1, TFCP2, FANCD2, HCVgp1, ZC3H18, CERK, FGD5, PTCHD2, SNIP1, NEK4, DUX4, CIT, ANLN, AURKB, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, C1QBP, INS, NDN, Rnf183, BRD4, RBM45, CIC, Apc2, FBP1, LGALS9, RIN3, POU2F1, SPOP, UFL1, DDRGK1, TRIM37, ATG10, ATG3, FZR1, WDR5, NUDCD2, RSL1D1, URB1, PURG, CCDC86, RPL23AP32, RPL7L1, PRKRA, H1FOO, NVL, SPOCK2, FGF13, LY86, DDX27, HIST1H1B, PPP1R9B, FGFBP1, CUEDC1, SPECC1L, HIST1H2AM, LIN28A, MTX3, RPSAP58, NEIL1, SRSF6, MYO18A, ZNF346, MTX2, SPRTN, BTF3, SLFN11, FBXW7, RCHY1, CCNF, MAP1LC3B, PSMD9, ZEB1,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPS14	ESCA	chr5	149827198	149827198	G	C	Missense_Mutation	p.I33M	5
RPS14	KIRP	chr5	149827271	149827271	T	C	Missense_Mutation	p.K9R	4
RPS14	SKCM	chr5	149826385	149826385	G	A	Silent	p.L97L	4
RPS14	ESCA	chr5	149827257	149827257	C	T	Missense_Mutation	p.V14I	3
RPS14	BRCA	chr5	149826455	149826455	G	C	Missense_Mutation	p.A74G	3
RPS14	CESC	chr5	149826526	149826526	C	T	Silent		2
RPS14	UCS	chr5	149826514	149826514	G	A	Silent	p.C54C	2
RPS14	LUAD	chr5	149826406	149826406	G	A	Silent	p.I90I	2
RPS14	ESCA	chr5	149827257	149827257	C	T	Missense_Mutation		2
RPS14	ESCA	chr5	149827255	149827255	G	T	Silent		2
RPS14	ESCA	chr5	149827255	149827255	G	T	Silent	p.V14V	2
RPS14	BRCA	chr5	149825182	149825182	G	A	Silent	p.I126	2
RPS14	STAD	chr5	149826448	149826448	C	A	Missense_Mutation	p.L76F	2
RPS14	STAD	chr5	149826384	149826384	G	A	Missense_Mutation	p.R98W	1
RPS14	KIRP	chr5	149827271	149827271	T	C	Missense_Mutation		1
RPS14	UCS	chr5	149826514	149826514	G	A	Silent		1
RPS14	COAD	chr5	149826526	149826526	C	T	Silent	p.K50K	1
RPS14	LIHC	chr5	149825226	149825226	C	-	Frame_Shift_Del	p.A112fs	1
RPS14	LIHC	chr5	149827279	149827279	C	-	Frame_Shift_Del	p.G6fs	1
RPS14	ESCA	chr5	149827255	149827255	G	T	Silent	p.V14	1
RPS14	LIHC	chr5	149823872	149823872	C	T	Missense_Mutation		1
RPS14	ESCA	chr5	149827198	149827198	G	C	Missense_Mutation		1
RPS14	OV	chr5	149806650	149806660	AGCATATGGTG	-	Frame_Shift_Del	p.S70fs	1
RPS14	SKCM	chr5	149823899	149823899	G	A	Missense_Mutation	p.P136S	1
RPS14	SKCM	chr5	149826527	149826527	C	T	Splice_Site		1
RPS14	HNSC	chr5	149825199	149825199	G	T	Missense_Mutation		1

Copy number variation (CNV) of RPS14
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPS14
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
91685	N/A	EC556529	COQ4	chr9	131094534	+	RPS14	chr5	149823910	-
91685	N/A	EC560630	FER	chr5	108121980	-	RPS14	chr5	149823825	+
91685	N/A	AA450315	HDLBP	chr2	242176108	-	RPS14	chr5	149823912	-
91685	N/A	AA533122	KCNJ4	chr22	38844251	-	RPS14	chr5	149823801	+
91685	N/A	AA572870	MAGI3	chr1	114052999	+	RPS14	chr5	149823801	+
91685	N/A	CN271804	METTL4	chr18	2542393	-	RPS14	chr5	149823882	-
91685	N/A	AA314699	MINOS1	chr1	19935110	+	RPS14	chr5	149827301	-
91685	N/A	AA534250	MINOS1	chr1	19935119	+	RPS14	chr5	149823827	+
91685	N/A	AA578345	MINOS1	chr1	19934759	-	RPS14	chr5	149823802	+
91685	N/A	AA747261	MINOS1	chr1	19934680	-	RPS14	chr5	149823801	+
91685	N/A	BF344377	MINOS1-NBL1	chr1	19935110	+	RPS14	chr5	149827301	-
91685	N/A	AA532581	MSI2	chr17	55664211	-	RPS14	chr5	149823801	+
91040	LUAD	TCGA-73-4666-01A	RPS14	chr5	149823794	-	AP1G2	chr14	24037279	-
103122	N/A	AA524656	RPS14	chr5	149823801	-	CNBD2	chr20	34582500	+
91800	N/A	BI857979	RPS14	chr5	149823801	-	DPP6	chr7	153462619	+
103040	OV	TCGA-13-0901-01B	RPS14	chr5	149826365	-	GAPDH	chr12	6647331	+
77405	LUSC	TCGA-85-8584	RPS14	chr5	149828778	-	IGHG3	chr14	106329449	-
77405	LUSC	TCGA-60-2714	RPS14	chr5	149829233	-	IGLC3	chr22	23241806	+
96006	N/A	BI859792	RPS14	chr5	149823792	-	KCNQ5	chr6	73222484	+
100402	BLCA	TCGA-CU-A72E	RPS14	chr5	149826364	-	MB21D2	chr3	192517439	-
100402	BLCA	TCGA-CU-A72E-01A	RPS14	chr5	149826365	-	MB21D2	chr3	192517439	-
102773	N/A	AW023874	RPS14	chr5	149823801	-	MELK	chr9	36616843	-
98923	N/A	BM014658	RPS14	chr5	149823801	-	MINOS1	chr1	19934605	+
88106	N/A	BG034577	RPS14	chr5	149823796	-	PDGFA	chr7	537505	+
85354	N/A	AV695316	RPS14	chr5	149823802	-	PTPRJ	chr11	48060732	+
85779	N/A	BU602070	RPS14	chr5	149826368	-	RPS19	chr19	42373271	+
85013	STAD	TCGA-FP-8211-01A	RPS14	chr5	149827221	-	RRBP1	chr20	17595519	-
99067	N/A	BM680717	RPS14	chr5	149823906	+	WDR6	chr3	49050987	-
101154	N/A	AA548056	RPS14	chr5	149823801	-	ZBTB20	chr3	114509457	-
77405	N/A	CF124261	RPS14	chr5	149823805	-	ZHX3	chr20	39818668	-
91686	N/A	AV688332	TMEM135	chr11	86967610	-	RPS14	chr5	149827405	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	RPS14	0.000665526720029359	0.019
MESO	RPS14	0.00118256939477722	0.032
ACC	RPS14	0.00487985610319783	0.13

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPS14	0.0289192130697278	0.95
LGG	RPS14	0.0305588450219112	0.98
PAAD	RPS14	0.0480623242419904	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0027947	Neutropenia	1	CTD_human
C0205696	Anaplastic carcinoma	1	CTD_human
C0205697	Carcinoma, Spindle-Cell	1	CTD_human
C0205698	Undifferentiated carcinoma	1	CTD_human
C0740302	5q-syndrome	1	CTD_human;GENOMICS_ENGLAND;ORPHANET
C1257925	Mammary Carcinoma, Animal	1	CTD_human
C1292779	Myelodysplastic Syndrome with Isolated del(5q)	1	ORPHANET