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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPS18 (NCBI Gene ID:6222)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPS18
	Gene ID: 6222
	Gene Symbol	RPS18
	Gene ID	6222
	Gene Name	ribosomal protein S18
	Synonyms	D6S218E\|HKE3\|KE-3\|KE3\|S18
	Cytomap	6p21.32
	Type of Gene	protein-coding
	Description	40S ribosomal protein S18rhabdomyosarcoma antigen MU-RMS-40.21small ribosomal subunit protein uS13
	Modification date	20200320
	UniProtAcc	P62269

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPS18[title] AND translation [title] AND human.'

Gene	Title	PMID
RPS18	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
BRCA	RPS18	-1.10158173051468	0.000391662487298429
COAD	RPS18	1.09459381578659	0.00468936562538148

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
ACC	RPS18	2	1	0.00335987651617935	0.275602415458937	0.145350668896321	0.425080063726889	0.0534582688552308
KIRC	RPS18	2	1	0.0431857774843889	0.217640957633053	0.16655363925675	-0.202773358891875	-0.291706934527717
UCEC	RPS18	2	1	0.0230007609368794	0.236755342902711	0.126603620528324	0.290647607586492	0.477690079561962

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LAML	RPS18	-0.01559257	0.03449175
ESCA	RPS18	-0.037365395	0.045917831

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPS18 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	CGC	RPS18	NACA	0.814715864	9.77E-12
CHOL	TSG	RPS18	GNB2L1	0.828982445	2.03E-12
DLBC	CGC	RPS18	NACA	0.812292065	2.42E-12
DLBC	TSG	RPS18	GAS5	0.831196248	2.61E-13
DLBC	TSG	RPS18	GNB2L1	0.860381942	4.62E-15
GBM	Cell metabolism gene	RPS18	FAU	0.831763198	2.58E-45
GBM	TSG	RPS18	GAS5	0.82589538	3.65E-44
KICH	TSG	RPS18	GAS5	0.834025649	1.04E-24
KIRP	TSG	RPS18	GAS5	0.826980342	2.84E-82
LGG	Cell metabolism gene	RPS18	FAU	0.812989114	4.16E-126
LGG	CGC	RPS18	NACA	0.819752223	6.60E-130
LGG	TSG	RPS18	GNB2L1	0.849040603	2.01E-148
MESO	CGC	RPS18	NACA	0.800750213	1.29E-20
PCPG	TSG	RPS18	GNB2L1	0.851502415	9.26E-54
PRAD	CGC	RPS18	NACA	0.874362208	3.25E-174
PRAD	TSG	RPS18	GAS5	0.867284779	3.85E-168
PRAD	TSG	RPS18	GNB2L1	0.884144833	3.02E-183
THCA	TSG	RPS18	GNB2L1	0.85273381	6.74E-163
UVM	CGC	RPS18	CCNB1IP1	0.835447407	5.65E-22
UVM	TSG	RPS18	GAS5	0.806369541	1.79E-19

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPS18	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPS18	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPS18	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPS18	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPS18	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPS18	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPS18	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPS18	RPL19	1.36901182894089	0.00250792503356934
KICH	RPS18	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPS18	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPS18	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPS18	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPS18	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPS18	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPS18	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPS18	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPS18	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPS18	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPS18	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPS18	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPS18	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPS18	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPS18	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPS18	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPS18	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPS18	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPS18	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPS18	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPS18

CAMK2D, AGO4, EBNA-LP, RAD21, SENP3, PARD3, ERG, CUL3, CUL4A, CUL4B, CUL2, CDK2, CUL1, COPS5, CAND1, RPS4X, APP, RPS15, MRPL3, MRPL2, TCIRG1, MRPL22, MRPL51, DNAJA3, MRPL43, ATP6V1D, LAMTOR3, MRPL4, ICT1, MRPL52, MRPS9, ATP6V0A1, ESR1, SMURF1, ESR2, VCAM1, FN1, CSNK2A1, NOS2, UBL4A, ITGA4, HCVgp1, US3, RL1, PAN2, CD81, IGSF8, ICAM1, TARDBP, EIF3A, EIF3E, RPSA, LARP1, RPS10, RPS12, RPS13, RPS14, RPS15A, RPS16, EIF3CL, EIF3D, EIF3L, FAU, GNB2L1, RPL28, RPS19, RPS2, RPS20, RPS23, RPS24, RPS29, RPS21, RPS25, RPS26, RPS27, RPS28, RPS3A, RPS3, RPS5, RPS6, RPS7, RPS8, RPS9, TSR1, WIBG, CEP250, CEP57, TUBG1, TUBGCP3, TP53, HUWE1, PHF6, CUL7, CCDC8, WDR76, RPS6KB2, MRPL24, MRPS10, RPL10A, RPL26, RPL26L1, RPL3, RPL31, RPL35, RPL3L, RPS11, ATP1B2, KRR1, RPL10, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL15, RPL17, RPL18, RPL18A, RPL19, RPL21, RPL22, RPL23, RPL23A, RPL24, RPL27, RPL27A, RPL30, RPL34, RPL35A, RPL36, RPL37A, RPL38, RPL39, RPL4, RPL5, RPL6, RPL7, RPL7A, RPL8, RPL9, RPLP0, RPLP1, RPLP2, LOC101929876, SFN, BTRC, XPO1, HIST1H3E, AHSA1, HNRNPU, NPM1, Eif3a, Eif3e, Rpl35, Srp72, Rrbp1, TRIM29, MCM2, MCM5, CCNB1, RRS1, H2AFX, NCL, CYLD, HEY1, BRCA1, MTF1, HDAC6, EXOSC2, FAM208A, UBA2, ZNF598, FBXO7, TMPO, ACO2, WDR77, TGFB1, TRIP4, UBE2M, PRPF8, EFTUD2, AAR2, PIH1D1, RNF4, CHD3, CHD4, LARP7, RNF31, TNF, SPDL1, RIOK1, HEXIM1, MEPCE, RNF123, RNF181, SNAI1, RECQL4, DCPS, REST, ZFP36L2, MYC, CDK9, Prkaa1, Prkab1, FBL, GRWD1, METTL14, KIAA1429, EIF4B, RC3H1, RC3H2, ACTC1, PHB, RBX1, TET2, USP14, NR2C2, PPP1CC, KRAS, VRK1, VRK3, HIST1H4A, APEX1, SNRNP70, ITFG1, ARAF, HMGB1, PPP1CA, BIRC3, STAU1, WWP2, TRIM28, ARIH2, PLEKHA4, PINK1, YAP1, TFCP2, FANCD2, ZC3H18, MAP3K14, KCNN1, ZNF232, nsp13, ORF10, ORF8, NEK4, DUX4, CIT, ANLN, AURKB, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, FASN, INS, NDN, Rnf183, RBM45, CIC, Apc2, RBM39, FBP1, GSK3A, GSK3B, INSIG2, RIN3, DDX58, SPOP, PARK2, UFL1, DDRGK1, TRIM37, ATG10, FZR1, PAGE4, NUDCD2, FGF13, H2AFB2, PRR3, HIST1H1B, YBX2, RPSAP58, ZNF346, SPRTN, BTF3, SLFN11, FBXW7, Kifap3, nsp1, RCHY1, CCNF, USP1, PSMD9, ZEB1, BRD4,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPS18	BLCA	chr6	33243782	33243782	A	G	Missense_Mutation		12
RPS18	PCPG	chr6	33243782	33243782	A	G	Missense_Mutation	p.Y77C	4
RPS18	UCEC	chr6	33240496	33240496	C	T	Missense_Mutation	p.A32V	2
RPS18	KIRC	chr6	33240437	33240437	T	C	Silent	p.I12I	2
RPS18	SKCM	chr6	33243594	33243594	T	G	Silent	p.A41A	2
RPS18	UCEC	chr6	33243786	33243786	G	T	Missense_Mutation	p.K78N	2
RPS18	KIRP	chr6	33244222	33244222	G	T	Silent		2
RPS18	SKCM	chr6	33240442	33240442	G	T	Missense_Mutation	p.R14L	2
RPS18	BLCA	chr6	33244172	33244172	C	T	Missense_Mutation	p.R130C	2
RPS18	SKCM	chr6	33244213	33244213	C	T	Silent	p.G143G	2
RPS18	BLCA	chr6	33244179	33244179	G	A	Missense_Mutation	p.R132Q	2
RPS18	LGG	chr6	33244215	33244215	G	A	Missense_Mutation	p.R144H	2
RPS18	LGG	chr6	33244215	33244215	G	A	Missense_Mutation		2
RPS18	BLCA	chr6	33243622	33243622	G	A	Missense_Mutation	p.D51N	2
RPS18	BLCA	chr6	33243657	33243657	T	C	Silent	p.D62D	2
RPS18	LIHC	chr6	33243784	33243784	A	-	Frame_Shift_Del	p.K78fs	2
RPS18	STAD	chr6	33244009	33244009	G	A	Silent	p.K116K	2
RPS18	STAD	chr6	33240412	33240412	T	C	Missense_Mutation	p.V4A	2
RPS18	UCEC	chr6	33240411	33240411	G	A	Missense_Mutation	p.V4M	2
RPS18	KIRC	chr6	33240470	33240470	G	A	Silent	p.R23R	2
RPS18	BLCA	chr6	33243622	33243622	G	A	Missense_Mutation		1
RPS18	LGG	chr6	33243984	33243984	G	A	Missense_Mutation	p.R108H	1
RPS18	SKCM	chr6	33243639	33243639	G	A	Silent	p.A56A	1
RPS18	BLCA	chr6	33244237	33244237	G	C	Missense_Mutation	p.K151N	1
RPS18	SKCM	chr6	33244018	33244018	C	T	Silent	p.A119A	1
RPS18	LIHC	chr6	33243990	33243990	A	G	Missense_Mutation		1
RPS18	SKCM	chr6	33240417	33240417	C	T	Missense_Mutation	p.P6S	1
RPS18	BLCA	chr6	33244009	33244009	G	C	Missense_Mutation	p.K116N	1
RPS18	LIHC	chr6	33240474	33240474	A	-	Frame_Shift_Del	p.K25fs	1
RPS18	BLCA	chr6	33243640	33243640	G	A	Missense_Mutation	p.G57R	1
RPS18	LUAD	chr6	33243778	33243778	C	T	Nonsense_Mutation	p.Q76*	1
RPS18	BLCA	chr6	33244172	33244172	C	T	Missense_Mutation		1
RPS18	THYM	chr6	33240466	33240466	G	T	Missense_Mutation	p.G22V	1
RPS18	CESC	chr6	33239880	33239880	C	A	RNA	NULL	1
RPS18	LUSC	chr6	33244195	33244195	G	C	Missense_Mutation	p.K137N	1
RPS18	BLCA	chr6	33244179	33244179	G	A	Missense_Mutation		1

Copy number variation (CNV) of RPS18
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPS18
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
102766	N/A	EC566297	CNTN6	chr3	1282379	-	RPS18	chr6	33244274	-
102766	PRAD	TCGA-VN-A88L	ERG	chr21	39947585	-	RPS18	chr6	33240404	+
102766	PRAD	TCGA-VN-A88L-01A	ERG	chr21	39947586	-	RPS18	chr6	33240405	+
102766	N/A	AA225162	PCNP	chr3	101295598	+	RPS18	chr6	33244284	-
77518	N/A	BG576416	RPS18	chr6	33244281	+	CTC-329D1.2	chr5	139774489	-
91800	N/A	BM015120	RPS18	chr6	33244282	+	DPP6	chr7	153580485	-
102975	HNSC	TCGA-MT-A67A	RPS18	chr6	33239899	+	EVL	chr14	100607516	+
95209	STAD	TCGA-BR-8077-01A	RPS18	chr6	33243660	+	HM13	chr20	30102262	+
92028	N/A	AA502900	RPS18	chr6	33244279	+	PCNP	chr3	101295342	-
92028	N/A	AA659604	RPS18	chr6	33244282	+	PCNP	chr3	101295322	-
92028	N/A	BF219371	RPS18	chr6	33244283	+	PCNP	chr3	101295830	-
92028	N/A	BI860255	RPS18	chr6	33244284	+	PCNP	chr3	101295341	-
92028	N/A	BM014578	RPS18	chr6	33244286	+	PCNP	chr3	101295684	-
102766	N/A	AW865643	RPS18	chr6	33240113	-	RPS18	chr6	33240203	+
95117	N/A	EC461661	RPS18	chr6	33244280	+	TTC7B	chr14	91233313	+
95394	N/A	EC557931	RPS18	chr6	33244233	-	TUBG1	chr17	40767199	+
102766	N/A	BI495049	SLC25A21	chr14	37205043	+	RPS18	chr6	33244281	-
102766	N/A	AA513071	TTC7B	chr14	91233373	+	RPS18	chr6	33244261	-
102769	SARC	TCGA-DX-A8BM-01A	ZNF704	chr8	81785779	-	RPS18	chr6	33240405	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
MESO	RPS18	0.00738882882925267	0.21
KIRC	RPS18	0.0157859700033779	0.43
TGCT	RPS18	0.0389697214561747	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPS18	0.0186000090535498	0.58
BRCA	RPS18	0.000101244531327592	0.0033
PAAD	RPS18	0.00109155054839416	0.035

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source