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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPS23 (NCBI Gene ID:6228)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPS23
	Gene ID: 6228
	Gene Symbol	RPS23
	Gene ID	6228
	Gene Name	ribosomal protein S23
	Synonyms	BTDD\|MABAS\|MCINS\|PAMAS\|S23\|uS12
	Cytomap	5q14.2
	Type of Gene	protein-coding
	Description	40S ribosomal protein S23homolog of yeast ribosomal protein S28small ribosomal subunit protein uS12
	Modification date	20200313
	UniProtAcc	P62266

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:1990145	Maintenance of translational fidelity
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPS23	GO:0002181	cytoplasmic translation	25957688

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPS23	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPS23[title] AND translation [title] AND human.'

Gene	Title	PMID
RPS23	OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation	24550447

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
STAD	RPS23	1.85076760664576	0.000364991836249828
LUSC	RPS23	1.46751169891047	0.0174932185880974
UCEC	RPS23	-2.03658159814007	0.046875

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
DLBC	RPS23	hsa-miR-139-5p	98	0.310938945420907	0.0338359687702221
UCEC	RPS23	hsa-miR-139-5p	98	-0.406875477463713	0.0176126407203776

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
ESCA	RPS23	-0.059364699	0.00463242

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPS23 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
BLCA	TSG	RPS23	GNB2L1	0.820661564	4.18E-105
CESC	TSG	RPS23	GNB2L1	0.867791745	6.10E-95
CHOL	CGC	RPS23	NACA	0.835047277	9.97E-13
CHOL	TSG	RPS23	GNB2L1	0.813343272	1.13E-11
COAD	TSG	RPS23	GNB2L1	0.839880497	8.70E-89
DLBC	CGC	RPS23	NACA	0.857187627	7.50E-15
DLBC	TSG	RPS23	GNB2L1	0.909147117	4.06E-19
GBM	Cell metabolism gene	RPS23	FAU	0.815083156	3.74E-42
GBM	Cell metabolism gene	RPS23	PFDN5	0.822421919	1.67E-43
HNSC	TSG	RPS23	GNB2L1	0.813266542	9.69E-135
KIRP	TSG	RPS23	GNB2L1	0.802814904	4.47E-74
LGG	Cell metabolism gene	RPS23	FAU	0.809561886	3.06E-124
LGG	CGC	RPS23	NACA	0.863932004	2.04E-159
LGG	TSG	RPS23	GNB2L1	0.811881382	1.69E-125
LGG	TSG	RPS23	GAS5	0.822718777	1.26E-131
LIHC	TSG	RPS23	GNB2L1	0.864290128	1.02E-127
MESO	TSG	RPS23	GNB2L1	0.848145978	3.57E-25
PRAD	CGC	RPS23	NACA	0.825924759	1.67E-138
PRAD	TSG	RPS23	GAS5	0.804819857	2.94E-126
PRAD	TSG	RPS23	GNB2L1	0.844784451	6.18E-151
TGCT	TSG	RPS23	GNB2L1	0.803545585	1.60E-36
THYM	Cell metabolism gene	RPS23	TXN	0.800085663	2.11E-28
THYM	Cell metabolism gene	RPS23	SNRPE	0.802911799	9.84E-29
THYM	Cell metabolism gene	RPS23	LSM3	0.802913639	9.83E-29
THYM	Cell metabolism gene	RPS23	SEC61G	0.805146761	5.33E-29
THYM	Cell metabolism gene	RPS23	TIMM8B	0.80553819	4.79E-29
THYM	Cell metabolism gene	RPS23	APOA1	0.806302836	3.87E-29
THYM	Cell metabolism gene	RPS23	SNRPG	0.808424248	2.14E-29
THYM	Cell metabolism gene	RPS23	PSMB7	0.809846185	1.43E-29
THYM	Cell metabolism gene	RPS23	SSR2	0.809896842	1.41E-29
THYM	Cell metabolism gene	RPS23	PSMA5	0.810569786	1.17E-29
THYM	Cell metabolism gene	RPS23	SNRPB	0.813298901	5.33E-30
THYM	Cell metabolism gene	RPS23	TOMM22	0.813620155	4.85E-30
THYM	Cell metabolism gene	RPS23	PSMC3	0.81448072	3.78E-30
THYM	Cell metabolism gene	RPS23	SNRPF	0.819741979	7.95E-31
THYM	Cell metabolism gene	RPS23	SNRPD1	0.824132554	2.08E-31
THYM	Cell metabolism gene	RPS23	PSMD13	0.82981955	3.47E-32
THYM	Cell metabolism gene	RPS23	SEC61B	0.83008556	3.18E-32
THYM	Cell metabolism gene	RPS23	ZNRD1	0.841145408	7.95E-34
THYM	Cell metabolism gene	RPS23	SNRPD2	0.842522392	4.92E-34
THYM	Cell metabolism gene	RPS23	LSM2	0.865607994	7.49E-38
THYM	Cell metabolism gene	RPS23	LSM5	0.873983781	2.04E-39
THYM	CGC	RPS23	NACA	0.807676245	2.64E-29
THYM	Epifactor	RPS23	FBL	0.801398983	1.48E-28
THYM	Epifactor	RPS23	PPM1G	0.80481244	5.85E-29
THYM	Epifactor	RPS23	RUVBL2	0.813700521	4.74E-30
THYM	Epifactor	RPS23	ANP32B	0.827446782	7.38E-32
THYM	Epifactor	RPS23	SS18L2	0.836286379	4.16E-33
THYM	Epifactor	RPS23	RBX1	0.842557929	4.86E-34
THYM	IUPHAR	RPS23	PPIA	0.822619737	3.32E-31
THYM	IUPHAR	RPS23	CSNK2B	0.823585564	2.46E-31
THYM	TF	RPS23	GTF3A	0.815271063	3.00E-30
THYM	TF	RPS23	ZNF444	0.819864262	7.66E-31
THYM	TF	RPS23	THYN1	0.85231171	1.42E-35
THYM	TSG	RPS23	PARK7	0.80078043	1.75E-28
THYM	TSG	RPS23	PFN1	0.802650614	1.06E-28
THYM	TSG	RPS23	AIP	0.836922767	3.36E-33
THYM	TSG	RPS23	GLTSCR2	0.849197512	4.51E-35
THYM	TSG	RPS23	GNB2L1	0.866347832	5.50E-38
UCS	Cell metabolism gene	RPS23	TXN	0.800085663	2.11E-28
UCS	Cell metabolism gene	RPS23	SNRPE	0.802911799	9.84E-29
UCS	Cell metabolism gene	RPS23	LSM3	0.802913639	9.83E-29
UCS	Cell metabolism gene	RPS23	SEC61G	0.805146761	5.33E-29
UCS	Cell metabolism gene	RPS23	TIMM8B	0.80553819	4.79E-29
UCS	Cell metabolism gene	RPS23	APOA1	0.806302836	3.87E-29
UCS	Cell metabolism gene	RPS23	SNRPG	0.808424248	2.14E-29
UCS	Cell metabolism gene	RPS23	PSMB7	0.809846185	1.43E-29
UCS	Cell metabolism gene	RPS23	SSR2	0.809896842	1.41E-29
UCS	Cell metabolism gene	RPS23	PSMA5	0.810569786	1.17E-29
UCS	Cell metabolism gene	RPS23	SNRPB	0.813298901	5.33E-30
UCS	Cell metabolism gene	RPS23	TOMM22	0.813620155	4.85E-30
UCS	Cell metabolism gene	RPS23	PSMC3	0.81448072	3.78E-30
UCS	Cell metabolism gene	RPS23	SNRPF	0.819741979	7.95E-31
UCS	Cell metabolism gene	RPS23	SNRPD1	0.824132554	2.08E-31
UCS	Cell metabolism gene	RPS23	PSMD13	0.82981955	3.47E-32
UCS	Cell metabolism gene	RPS23	SEC61B	0.83008556	3.18E-32
UCS	Cell metabolism gene	RPS23	ZNRD1	0.841145408	7.95E-34
UCS	Cell metabolism gene	RPS23	SNRPD2	0.842522392	4.92E-34
UCS	Cell metabolism gene	RPS23	LSM2	0.865607994	7.49E-38
UCS	Cell metabolism gene	RPS23	LSM5	0.873983781	2.04E-39
UCS	CGC	RPS23	NACA	0.807676245	2.64E-29
UCS	Epifactor	RPS23	FBL	0.801398983	1.48E-28
UCS	Epifactor	RPS23	PPM1G	0.80481244	5.85E-29
UCS	Epifactor	RPS23	RUVBL2	0.813700521	4.74E-30
UCS	Epifactor	RPS23	ANP32B	0.827446782	7.38E-32
UCS	Epifactor	RPS23	SS18L2	0.836286379	4.16E-33
UCS	Epifactor	RPS23	RBX1	0.842557929	4.86E-34
UCS	IUPHAR	RPS23	PPIA	0.822619737	3.32E-31
UCS	IUPHAR	RPS23	CSNK2B	0.823585564	2.46E-31
UCS	TF	RPS23	GTF3A	0.815271063	3.00E-30
UCS	TF	RPS23	ZNF444	0.819864262	7.66E-31
UCS	TF	RPS23	THYN1	0.85231171	1.42E-35
UCS	TSG	RPS23	PARK7	0.80078043	1.75E-28
UCS	TSG	RPS23	PFN1	0.802650614	1.06E-28
UCS	TSG	RPS23	AIP	0.836922767	3.36E-33
UCS	TSG	RPS23	GLTSCR2	0.849197512	4.51E-35
UCS	TSG	RPS23	GNB2L1	0.866347832	5.50E-38
UVM	CGC	RPS23	NACA	0.888173146	4.61E-28
UVM	TSG	RPS23	GNB2L1	0.815677599	3.16E-20
UVM	TSG	RPS23	GAS5	0.8560664	4.61E-24

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPS23	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPS23	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPS23	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPS23	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPS23	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPS23	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPS23	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPS23	RPL19	1.36901182894089	0.00250792503356934
KICH	RPS23	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPS23	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPS23	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPS23	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPS23	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPS23	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPS23	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPS23	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPS23	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPS23	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPS23	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPS23	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPS23	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPS23	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPS23	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPS23	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPS23	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPS23	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPS23	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPS23	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPS23

POU5F1, MME, EBNA-LP, HDGF, SIRT7, CUL2, CDK2, CUL1, COPS5, CAND1, NEDD8, RPL5, RPL10A, RPL10, RPL11, RPL12, RPL13, RPL14, RPL15, RPL18A, RPL18, RPL19, RPL21, RPL23A, RPL23, RPL24, RPL27, RPL31, RPL37A, RPL3, RPL6, RPL7A, RPL7, RPL8, RPL9, RPS11, RPS12, RPS13, RPS14, RPS16, RPS19, RPS20, RPS25, RPS28, RPS3A, RPS3, RPS4X, RPS5, RPS6, RPS7, RPS8, RPSA, RPS17, RPS2, RPS15A, RPL4, RPS24, RPL22, RPLP2, RPS26, RPL30, RPLP0, RPLP1, RPS9, RPS15, RPL17, RPL29, RPL32, RPS21, RPS27A, FAU, EEF2, EEF1A1, RPS29, HNRNPU, SLC25A5, ILF2, TUFM, HNRNPM, ILF3, MYBBP1A, ACTA2, DDX21, NHP2L1, NCL, NOLC1, HSP90AB1, RPL10L, RPS10P5, RPLP0P6, RPS27L, HNRNPR, VASN, SAMM50, HIST1H2AD, MRPL55, MRPS11, PSMB1, ESR1, FN1, PAN2, CD81, IGSF8, ICAM1, TARDBP, EIF3A, EIF3CL, EIF3E, PNO1, RPS18, DDX3X, DYNC1LI2, KIAA0368, EIF2A, FLNA, RPL28, RPS10, RPS27, SERBP1, TSR1, WIBG, rev, ZBTB1, CEP250, CEP57, CEP76, TUBG1, HUWE1, EED, WDR76, RPL13A, RPL27A, MRPL17, RPL34, RPL35, RPL36, RPL38, RPL3L, LOC101929876, MDM2, XPO1, AHSA1, KIF11, NPM1, Pabpc1, Pard6b, Srp72, Rrbp1, MCM2, ZNF746, CYLD, TRIM25, UBE2A, BRCA1, G3BP1, TMPO, BMP4, MAP2K1, PCBP1, PRPF8, AAR2, PIH1D1, EFTUD2, RNF4, CHD3, RNF31, TNF, SPDL1, RIOK1, HEXIM1, MEPCE, LARP7, SNAI1, AGR2, RECQL4, REST, MYC, FBL, GRWD1, EIF4B, RC3H1, RC3H2, ESR2, PHB, RBX1, USP14, NR2C2, PPP1CC, CTCF, VRK1, HIST1H4A, SNRNP70, ITFG1, BIRC3, STAU1, NFX1, WWP2, TRIM28, OGFOD1, ARIH2, DARS-AS1, PLEKHA4, YAP1, TFCP2, FANCD2, PTEN, HCVgp1, ZC3H18, DDX54, M, nsp4, nsp6, ORF7b, NEK4, CIT, ANLN, AURKB, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, C1QBP, TBRG4, FASN, INS, NDN, BRD4, NINL, NUPR1, CIC, Apc2, RBM39, FBP1, LGALS9, DNAJA3, DNAJC8, DDX58, AR, PARK2, UFL1, DDRGK1, MARCKS, PARP1, ATG10, ATG3, FZR1, WDR5, PAGE4, NAA40, NOTCH2, CDH23, HIST1H1A, MAGEB2, PRKRA, SPRTN, BTF3, FBXW7, DPP4, RCHY1, MAP1LC3B, SIRT6, RB1CC1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RPS23	chr5	81571931	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS23	chr5	81572002	A	T	single_nucleotide_variant	Pathogenic	MacInnes_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS23	chr5	81572184	G	C	single_nucleotide_variant	Benign	MacInnes_syndrome	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS23	chr5	81572238	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS23	chr5	81572302	C	T	single_nucleotide_variant	Pathogenic	MacInnes_syndrome\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS23	chr5	81573537	C	T	single_nucleotide_variant	Uncertain_significance	MacInnes_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPS23	LIHC	chr5	81573532	81573532	T	-	Frame_Shift_Del	p.K48fs	2
RPS23	LIHC	chr5	81573557	81573557	G	-	Frame_Shift_Del	p.P40fs	2
RPS23	CESC	chr5	81573526	81573526	G	A	Silent		2
RPS23	SARC	chr5	81571946	81571946	C	G	Missense_Mutation	p.K138N	2
RPS23	CESC	chr5	81573540	81573540	G	A	Missense_Mutation		2
RPS23	STAD	chr5	81573573	81573573	C	T	Missense_Mutation	p.A35T	2
RPS23	CESC	chr5	81573540	81573540	G	A	Missense_Mutation	p.H46Y	2
RPS23	STAD	chr5	81573622	81573622	T	G	Silent	p.R18R	2
RPS23	UCEC	chr5	81572316	81572316	T	C	Silent	p.P62	2
RPS23	HNSC	chr5	81571952	81571952	G	A	Silent		1
RPS23	HNSC	chr5	81571953	81571953	C	T	Missense_Mutation		1
RPS23	LIHC	chr5	81573513	81573514	-	T	Frame_Shift_Ins	p.NV54fs	1
RPS23	HNSC	chr5	81572197	81572197	G	A	Missense_Mutation		1
RPS23	OV	chr5	81609905	81609905	G	A	Silent	p.A30	1
RPS23	CESC	chr5	81572184	81572184	G	C	Missense_Mutation		1
RPS23	HNSC	chr5	81571973	81571973	A	G	Silent	p.S129S	1
RPS23	SARC	chr5	81571946	81571946	C	G	Missense_Mutation		1
RPS23	HNSC	chr5	81571953	81571953	C	T	Missense_Mutation	p.G136D	1
RPS23	HNSC	chr5	81571952	81571952	G	A	Splice_Site	p.G78_splice	1
RPS23	SKCM	chr5	81573643	81573643	C	T	Silent	p.R11R	1
RPS23	CESC	chr5	81572280	81572280	C	A	Silent		1
RPS23	HNSC	chr5	81571952	81571953	GC	AT	Missense_Mutation	p.G136D	1
RPS23	LIHC	chr5	81573513	81573514	-	-	Frame_Shift_Ins		1
RPS23	CESC	chr5	81573526	81573526	G	A	Silent	p.I50I	1
RPS23	LIHC	chr5	81573513	81573514	-	T	Frame_Shift_Ins	p.V55fs	1
RPS23	THYM	chr5	81572043	81572043	C	A	Missense_Mutation	p.G106V	1
RPS23	CESC	chr5	81573526	81573526	G	A	Silent	p.I50	1
RPS23	LIHC	chr5	81572069	81572070	-	T	Frame_Shift_Ins	p.R97fs	1
RPS23	COAD	chr5	81572042	81572042	A	G	Silent	p.G106G	1

Copy number variation (CNV) of RPS23
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPS23
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
95311	N/A	EC565927	CDH23	chr10	73431054	+	RPS23	chr5	81571888	+
95311	N/A	H17554	CUTA	chr6	33385911	+	RPS23	chr5	81570373	-
95311	N/A	AI982804	EFNA5	chr5	106714041	+	RPS23	chr5	81571295	+
95311	N/A	AI889745	NLGN4X	chrX	6143763	+	RPS23	chr5	81571879	+
95311	Non-Cancer	ERR315465	PABPC1	chr8	101730411	-	RPS23	chr5	81573671	-
101684	OV	TCGA-24-1464	RPS23	chr5	81572216	-	ATP5B	chr12	57036615	-
99462	OV	TCGA-61-2110	RPS23	chr5	81573511	-	BEX1	chrX	102318207	-
97608	COAD	TCGA-AZ-4308-01A	RPS23	chr5	81573519	-	GDI2	chr10	5855222	-
101053	N/A	GW493247	RPS23	chr5	81571879	-	GPC5	chr13	92763829	+
95311	N/A	N22397	RPS23	chr5	81571945	+	RPS23	chr5	81571977	-
83858	N/A	AI908980	RPS23	chr5	81573514	-	RPS24	chr10	79799960	+
102305	N/A	BI859685	RPS23	chr5	81571879	-	STX8	chr17	9218457	+
95311	N/A	BF154662	SNX19	chr11	130753340	+	RPS23	chr5	81573597	-
95311	STAD	TCGA-BR-4187-01A	SSBP2	chr5	81046800	-	RPS23	chr5	81573671	-
95321	N/A	BM785206	TUBA1C	chr12	49663672	+	RPS23	chr5	81571955	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	RPS23	0.000203847423254295	0.0057
TGCT	RPS23	0.0108365200967807	0.29

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
GBM	RPS23	0.0255929444453529	0.84
PAAD	RPS23	0.0413775848690731	1
THYM	RPS23	0.0320638955290254	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C4479431	BRACHYCEPHALY, TRICHOMEGALY, AND DEVELOPMENTAL DELAY	1	CTD_human;GENOMICS_ENGLAND;UNIPROT