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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: CCL5 (NCBI Gene ID:6352)

Gene Summary

Gene Summary

Gene Information	Gene Name: CCL5
	Gene ID: 6352
	Gene Symbol	CCL5
	Gene ID	6352
	Gene Name	C-C motif chemokine ligand 5
	Synonyms	D17S136E\|RANTES\|SCYA5\|SIS-delta\|SISd\|TCP228\|eoCP
	Cytomap	17q12
	Type of Gene	protein-coding
	Description	C-C motif chemokine 5T-cell specific protein p288beta-chemokine RANTESchemokine (C-C motif) ligand 5eosinophil chemotactic cytokineregulated upon activation, normally T-expressed, and presumably secretedsmall inducible cytokine subfamily A (Cys-Cys)
	Modification date	20200313
	UniProtAcc	P13501

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0045727	Positive regulation of translation
GO:0006413	Translational initiation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CCL5	GO:0006816	calcium ion transport	10734056
Hgene	CCL5	GO:0006874	cellular calcium ion homeostasis	10734056
Hgene	CCL5	GO:0006887	exocytosis	10734056
Hgene	CCL5	GO:0006954	inflammatory response	21147091
Hgene	CCL5	GO:0007159	leukocyte cell-cell adhesion	8558019
Hgene	CCL5	GO:0007186	G protein-coupled receptor signaling pathway	17001303\|23979485
Hgene	CCL5	GO:0007267	cell-cell signaling	8558019
Hgene	CCL5	GO:0009636	response to toxic substance	10841574
Hgene	CCL5	GO:0010759	positive regulation of macrophage chemotaxis	16778803
Hgene	CCL5	GO:0010820	positive regulation of T cell chemotaxis	1699135\|7544376\|16778803\|18337562
Hgene	CCL5	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	7544376
Hgene	CCL5	GO:0014911	positive regulation of smooth muscle cell migration	21297082
Hgene	CCL5	GO:0030335	positive regulation of cell migration	7545673
Hgene	CCL5	GO:0031328	positive regulation of cellular biosynthetic process	18337562
Hgene	CCL5	GO:0031584	activation of phospholipase D activity	9469451
Hgene	CCL5	GO:0031663	lipopolysaccharide-mediated signaling pathway	21147091
Hgene	CCL5	GO:0033634	positive regulation of cell-cell adhesion mediated by integrin	8558019
Hgene	CCL5	GO:0034112	positive regulation of homotypic cell-cell adhesion	10488085
Hgene	CCL5	GO:0042102	positive regulation of T cell proliferation	18832695
Hgene	CCL5	GO:0042119	neutrophil activation	10488085
Hgene	CCL5	GO:0042327	positive regulation of phosphorylation	18337562
Hgene	CCL5	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	9417081
Hgene	CCL5	GO:0043922	negative regulation by host of viral transcription	10841574
Hgene	CCL5	GO:0045071	negative regulation of viral genome replication	10490959
Hgene	CCL5	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	10734056
Hgene	CCL5	GO:0045785	positive regulation of cell adhesion	10910894
Hgene	CCL5	GO:0048245	eosinophil chemotaxis	16778803
Hgene	CCL5	GO:0048661	positive regulation of smooth muscle cell proliferation	21297082
Hgene	CCL5	GO:0050796	regulation of insulin secretion	23979485
Hgene	CCL5	GO:0050863	regulation of T cell activation	10488085
Hgene	CCL5	GO:0051928	positive regulation of calcium ion transport	8699119
Hgene	CCL5	GO:0070098	chemokine-mediated signaling pathway	17001303
Hgene	CCL5	GO:0070233	negative regulation of T cell apoptotic process	10488085
Hgene	CCL5	GO:0070234	positive regulation of T cell apoptotic process	10488085
Hgene	CCL5	GO:0071407	cellular response to organic cyclic compound	21147091
Hgene	CCL5	GO:0090026	positive regulation of monocyte chemotaxis	1699135\|19779041
Hgene	CCL5	GO:1901214	regulation of neuron death	17001303
Hgene	CCL5	GO:2000406	positive regulation of T cell migration	23620790
Hgene	CCL5	GO:2000503	positive regulation of natural killer cell chemotaxis	7545673

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
CCL5	(355.7 - 733]

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Translation Studies in PubMed

We searched PubMed using 'CCL5[title] AND translation [title] AND human.'

Gene	Title	PMID
CCL5	CCL5 promotes proliferation of MCF-7 cells through mTOR-dependent mRNA translation	19607806

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUSC	CCL5	-1.25151176208932	0.000752333130205602
KIRP	CCL5	-3.3268851895854	0.00192895717918873
KICH	CCL5	-1.21750365103418	0.0159729719161987
PRAD	CCL5	1.75222996908277	0.0382818994352287

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
LGG	CCL5	3	2	0.0101811136312523	0.777481916329285	0.519727777777778	-0.627733305709235	-0.824259891404572

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
ESCA	CCL5	-0.033721086	0.014131758
UVM	CCL5	-0.049665551	0.037973684

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with CCL5 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
ACC	Cell metabolism gene	CCL5	PIK3CD	0.822731609	1.41E-20
ACC	CGC	CCL5	IKZF1	0.822980904	1.34E-20
ACC	CGC	CCL5	PRF1	0.828267075	4.65E-21
ACC	CGC	CCL5	RHOH	0.837689505	6.38E-22
ACC	CGC	CCL5	ITK	0.842565848	2.17E-22
ACC	Epifactor	CCL5	IKZF1	0.822980904	1.34E-20
ACC	IUPHAR	CCL5	INPP5D	0.801151465	7.63E-19
ACC	IUPHAR	CCL5	GPR18	0.804149147	4.51E-19
ACC	IUPHAR	CCL5	IL12RB1	0.806265703	3.10E-19
ACC	IUPHAR	CCL5	LAIR1	0.806286928	3.09E-19
ACC	IUPHAR	CCL5	SLAMF7	0.807537711	2.47E-19
ACC	IUPHAR	CCL5	PDCD1	0.808735724	1.99E-19
ACC	IUPHAR	CCL5	CCR2	0.821535633	1.78E-20
ACC	IUPHAR	CCL5	PIK3CD	0.822731609	1.41E-20
ACC	IUPHAR	CCL5	ICOS	0.825358703	8.37E-21
ACC	IUPHAR	CCL5	PRF1	0.828267075	4.65E-21
ACC	IUPHAR	CCL5	TIGIT	0.838760977	5.05E-22
ACC	IUPHAR	CCL5	ITK	0.842565848	2.17E-22
ACC	IUPHAR	CCL5	CXCR3	0.847681598	6.73E-23
ACC	IUPHAR	CCL5	CCR5	0.84799653	6.25E-23
ACC	IUPHAR	CCL5	CD27	0.855715576	9.79E-24
ACC	IUPHAR	CCL5	GZMK	0.877953346	2.40E-26
ACC	IUPHAR	CCL5	ITGAL	0.877975171	2.39E-26
ACC	IUPHAR	CCL5	PYHIN1	0.88497074	2.81E-27
ACC	IUPHAR	CCL5	CXCR6	0.884982208	2.80E-27
ACC	IUPHAR	CCL5	GPR171	0.886943331	1.50E-27
ACC	IUPHAR	CCL5	IL2RG	0.888905276	7.95E-28
ACC	IUPHAR	CCL5	GZMA	0.908034116	7.95E-31
ACC	IUPHAR	CCL5	CD247	0.911440426	1.98E-31
ACC	IUPHAR	CCL5	CD3E	0.919066257	7.16E-33
ACC	IUPHAR	CCL5	CD2	0.919459645	5.98E-33
ACC	Kinase	CCL5	ITK	0.842565848	2.17E-22
ACC	TF	CCL5	STAT4	0.802688337	5.84E-19
ACC	TF	CCL5	IKZF1	0.822980904	1.34E-20
ACC	TF	CCL5	TBX21	0.834892662	1.16E-21
ACC	TF	CCL5	ZNF831	0.873044766	9.96E-26
ACC	TSG	CCL5	TNFAIP8L2	0.81138214	1.23E-19
ACC	TSG	CCL5	IKZF1	0.822980904	1.34E-20
ACC	TSG	CCL5	RARRES3	0.844181735	1.51E-22
ACC	TSG	CCL5	PYHIN1	0.88497074	2.81E-27
BLCA	IUPHAR	CCL5	CD2	0.800071402	3.90E-96
BLCA	IUPHAR	CCL5	CD3E	0.807546185	2.89E-99
BLCA	IUPHAR	CCL5	CCR5	0.820080377	7.75E-105
BRCA	CGC	CCL5	WAS	0.801010027	3.15E-273
BRCA	CGC	CCL5	JAK3	0.831080928	3.93013027279e-312
BRCA	CGC	CCL5	ITK	0.841511958	0
BRCA	CGC	CCL5	PRF1	0.884116038	0
BRCA	CGC	CCL5	LCK	0.89748366	0
BRCA	Epifactor	CCL5	GFI1	0.810087279	3.11E-284
BRCA	Epifactor	CCL5	SCML4	0.829806358	2.48949892184427e-310
BRCA	Epifactor	CCL5	SP140	0.833372652	2.072918997e-315
BRCA	IUPHAR	CCL5	MAP4K1	0.805991267	3.40E-279
BRCA	IUPHAR	CCL5	CTLA4	0.809230814	3.60E-283
BRCA	IUPHAR	CCL5	CD52	0.814451522	9.72E-290
BRCA	IUPHAR	CCL5	SLAMF7	0.823596416	9.22E-302
BRCA	IUPHAR	CCL5	S1PR4	0.828279231	3.43E-308
BRCA	IUPHAR	CCL5	JAK3	0.831080928	3.93013027279e-312
BRCA	IUPHAR	CCL5	ICOS	0.832920608	9.26998396e-315
BRCA	IUPHAR	CCL5	SP140	0.833372652	2.072918997e-315
BRCA	IUPHAR	CCL5	ZAP70	0.83501325	8.693717e-318
BRCA	IUPHAR	CCL5	ITK	0.841511958	0
BRCA	IUPHAR	CCL5	IL12RB1	0.844608396	0
BRCA	IUPHAR	CCL5	GPR171	0.849296531	0
BRCA	IUPHAR	CCL5	CCR5	0.849532902	0
BRCA	IUPHAR	CCL5	GZMK	0.850189088	0
BRCA	IUPHAR	CCL5	PDCD1	0.852706622	0
BRCA	IUPHAR	CCL5	TIGIT	0.856096662	0
BRCA	IUPHAR	CCL5	CD6	0.856187726	0
BRCA	IUPHAR	CCL5	PYHIN1	0.857632734	0
BRCA	IUPHAR	CCL5	CD27	0.862231903	0
BRCA	IUPHAR	CCL5	PRF1	0.884116038	0
BRCA	IUPHAR	CCL5	CXCR6	0.889411303	0
BRCA	IUPHAR	CCL5	CD247	0.892283049	0
BRCA	IUPHAR	CCL5	LCK	0.89748366	0
BRCA	IUPHAR	CCL5	CXCR3	0.89935532	0
BRCA	IUPHAR	CCL5	GZMA	0.908999434	0
BRCA	IUPHAR	CCL5	CD3E	0.915130498	0
BRCA	IUPHAR	CCL5	IL2RG	0.916294707	0
BRCA	IUPHAR	CCL5	CD2	0.922571673	0
BRCA	Kinase	CCL5	MAP4K1	0.805991267	3.40E-279
BRCA	Kinase	CCL5	JAK3	0.831080928	3.93013027279e-312
BRCA	Kinase	CCL5	ZAP70	0.83501325	8.693717e-318
BRCA	Kinase	CCL5	ITK	0.841511958	0
BRCA	Kinase	CCL5	LCK	0.89748366	0
BRCA	TF	CCL5	EOMES	0.805673981	8.25E-279
BRCA	TF	CCL5	ZNF831	0.80577742	6.18E-279
BRCA	TF	CCL5	GFI1	0.810087279	3.11E-284
BRCA	TF	CCL5	SCML4	0.829806358	2.48949892184427e-310
BRCA	TF	CCL5	SP140	0.833372652	2.072918997e-315
BRCA	TF	CCL5	ZNF683	0.840633402	0
BRCA	TF	CCL5	TBX21	0.896840196	0
BRCA	TSG	CCL5	MAP4K1	0.805991267	3.40E-279
BRCA	TSG	CCL5	PYHIN1	0.857632734	0
CESC	Cell metabolism gene	CCL5	GNGT2	0.805414547	1.75E-71
CESC	CGC	CCL5	WAS	0.840178455	2.59E-83
CESC	CGC	CCL5	PRF1	0.882159585	4.40E-102
CESC	Epifactor	CCL5	SCML4	0.835668658	1.26E-81
CESC	Epifactor	CCL5	SP140	0.837689737	2.25E-82
CESC	IUPHAR	CCL5	IL2RB	0.80318813	8.27E-71
CESC	IUPHAR	CCL5	HAVCR2	0.804368278	3.63E-71
CESC	IUPHAR	CCL5	IL12RB1	0.81227617	1.27E-73
CESC	IUPHAR	CCL5	CD27	0.813845115	4.02E-74
CESC	IUPHAR	CCL5	IL2RG	0.815034442	1.66E-74
CESC	IUPHAR	CCL5	PDCD1	0.819012289	8.32E-76
CESC	IUPHAR	CCL5	LAG3	0.83278047	1.43E-80
CESC	IUPHAR	CCL5	PYHIN1	0.837686132	2.25E-82
CESC	IUPHAR	CCL5	SP140	0.837689737	2.25E-82
CESC	IUPHAR	CCL5	ZAP70	0.838055371	1.64E-82
CESC	IUPHAR	CCL5	GPR171	0.839224459	5.96E-83
CESC	IUPHAR	CCL5	ITGAL	0.840243334	2.45E-83
CESC	IUPHAR	CCL5	CCR5	0.844702342	4.64E-85
CESC	IUPHAR	CCL5	CXCR3	0.848352203	1.64E-86
CESC	IUPHAR	CCL5	CD247	0.850511061	2.18E-87
CESC	IUPHAR	CCL5	CD52	0.858663635	7.96E-91
CESC	IUPHAR	CCL5	GZMA	0.870942839	1.96E-96
CESC	IUPHAR	CCL5	CXCR6	0.875332728	1.40E-98
CESC	IUPHAR	CCL5	TIGIT	0.882082884	4.83E-102
CESC	IUPHAR	CCL5	PRF1	0.882159585	4.40E-102
CESC	IUPHAR	CCL5	CD2	0.894770835	3.63E-109
CESC	IUPHAR	CCL5	CD3E	0.913814209	8.91E-122
CESC	Kinase	CCL5	ZAP70	0.838055371	1.64E-82
CESC	TF	CCL5	SCML4	0.835668658	1.26E-81
CESC	TF	CCL5	SP140	0.837689737	2.25E-82
CESC	TF	CCL5	ZNF683	0.858454937	9.81E-91
CESC	TF	CCL5	TBX21	0.892201755	1.18E-107
CESC	TSG	CCL5	DOK2	0.814802303	1.98E-74
CESC	TSG	CCL5	PYHIN1	0.837686132	2.25E-82
CHOL	Cell metabolism gene	CCL5	GNGT2	0.809893627	1.61E-11
CHOL	CGC	CCL5	ITK	0.809932121	1.61E-11
CHOL	CGC	CCL5	GATA3	0.812816659	1.19E-11
CHOL	CGC	CCL5	PRF1	0.837735366	7.20E-13
CHOL	CGC	CCL5	WAS	0.842442512	4.02E-13
CHOL	CGC	CCL5	LCK	0.91148098	3.40E-18
CHOL	Epifactor	CCL5	GFI1	0.828811001	2.07E-12
CHOL	IUPHAR	CCL5	ICOS	0.808089165	1.94E-11
CHOL	IUPHAR	CCL5	ITK	0.809932121	1.61E-11
CHOL	IUPHAR	CCL5	AIM2	0.812925982	1.18E-11
CHOL	IUPHAR	CCL5	GPR65	0.814096451	1.04E-11
CHOL	IUPHAR	CCL5	GPR171	0.816997113	7.67E-12
CHOL	IUPHAR	CCL5	IL2RB	0.819125132	6.10E-12
CHOL	IUPHAR	CCL5	SLAMF7	0.83294533	1.28E-12
CHOL	IUPHAR	CCL5	PRF1	0.837735366	7.20E-13
CHOL	IUPHAR	CCL5	CD52	0.844579474	3.07E-13
CHOL	IUPHAR	CCL5	CD6	0.848287911	1.90E-13
CHOL	IUPHAR	CCL5	CXCR3	0.853246522	9.78E-14
CHOL	IUPHAR	CCL5	IL12RB1	0.86577321	1.64E-14
CHOL	IUPHAR	CCL5	CD247	0.868119477	1.15E-14
CHOL	IUPHAR	CCL5	CXCR6	0.873084043	5.30E-15
CHOL	IUPHAR	CCL5	PYHIN1	0.881113497	1.41E-15
CHOL	IUPHAR	CCL5	MAP4K1	0.882326813	1.15E-15
CHOL	IUPHAR	CCL5	GZMK	0.883375998	9.57E-16
CHOL	IUPHAR	CCL5	TIGIT	0.886753754	5.27E-16
CHOL	IUPHAR	CCL5	ZAP70	0.897686458	6.65E-17
CHOL	IUPHAR	CCL5	GZMA	0.904872379	1.50E-17
CHOL	IUPHAR	CCL5	LCK	0.91148098	3.40E-18
CHOL	IUPHAR	CCL5	CCR5	0.916657391	9.82E-19
CHOL	IUPHAR	CCL5	CD2	0.921209166	3.07E-19
CHOL	IUPHAR	CCL5	CD3E	0.928272659	4.38E-20
CHOL	Kinase	CCL5	ITK	0.809932121	1.61E-11
CHOL	Kinase	CCL5	MAP4K1	0.882326813	1.15E-15
CHOL	Kinase	CCL5	ZAP70	0.897686458	6.65E-17
CHOL	Kinase	CCL5	LCK	0.91148098	3.40E-18
CHOL	TF	CCL5	GATA3	0.812816659	1.19E-11
CHOL	TF	CCL5	GFI1	0.828811001	2.07E-12
CHOL	TF	CCL5	TBX21	0.891929878	2.03E-16
CHOL	TSG	CCL5	TNFAIP8L2	0.811309847	1.39E-11
CHOL	TSG	CCL5	AIM2	0.812925982	1.18E-11
CHOL	TSG	CCL5	DOK2	0.859776451	3.94E-14
CHOL	TSG	CCL5	PYHIN1	0.881113497	1.41E-15
CHOL	TSG	CCL5	MAP4K1	0.882326813	1.15E-15
COAD	CGC	CCL5	WAS	0.806660011	1.12E-76
COAD	CGC	CCL5	PRF1	0.809151198	1.68E-77
COAD	CGC	CCL5	CD74	0.825422988	3.35E-83
COAD	Epifactor	CCL5	APOBEC3G	0.802643875	2.26E-75
COAD	IUPHAR	CCL5	MAP4K1	0.806307956	1.46E-76
COAD	IUPHAR	CCL5	CD52	0.808650908	2.47E-77
COAD	IUPHAR	CCL5	PRF1	0.809151198	1.68E-77
COAD	IUPHAR	CCL5	CD74	0.825422988	3.35E-83
COAD	IUPHAR	CCL5	TIGIT	0.831795257	1.34E-85
COAD	IUPHAR	CCL5	GZMK	0.83287699	5.15E-86
COAD	IUPHAR	CCL5	ITGAL	0.837834245	5.79E-88
COAD	IUPHAR	CCL5	CXCR6	0.839098189	1.80E-88
COAD	IUPHAR	CCL5	PYHIN1	0.842628837	6.52E-90
COAD	IUPHAR	CCL5	CCR5	0.845692527	3.43E-91
COAD	IUPHAR	CCL5	GPR171	0.849141359	1.15E-92
COAD	IUPHAR	CCL5	CD247	0.853777822	1.05E-94
COAD	IUPHAR	CCL5	IL2RB	0.864417787	1.14E-99
COAD	IUPHAR	CCL5	CD2	0.873386481	3.41E-104
COAD	IUPHAR	CCL5	CD3E	0.874755359	6.49E-105
COAD	IUPHAR	CCL5	LAG3	0.877277738	2.90E-106
COAD	IUPHAR	CCL5	GZMA	0.899414477	1.44E-119
COAD	Kinase	CCL5	MAP4K1	0.806307956	1.46E-76
COAD	TF	CCL5	TBX21	0.887132836	7.66E-112
COAD	TSG	CCL5	MAP4K1	0.806307956	1.46E-76
COAD	TSG	CCL5	DOK2	0.81322237	7.11E-79
COAD	TSG	CCL5	PYHIN1	0.842628837	6.52E-90
ESCA	CGC	CCL5	PRF1	0.807754581	2.12E-46
ESCA	IUPHAR	CCL5	CD2	0.801002841	4.22E-45
ESCA	IUPHAR	CCL5	GZMA	0.805374391	6.16E-46
ESCA	IUPHAR	CCL5	PRF1	0.807754581	2.12E-46
ESCA	IUPHAR	CCL5	CD3E	0.817674138	2.09E-48
ESCA	TF	CCL5	TBX21	0.819217078	9.91E-49
GBM	CGC	CCL5	LCK	0.862064418	4.70E-52
GBM	IUPHAR	CCL5	CXCR3	0.802242103	6.25E-40
GBM	IUPHAR	CCL5	GZMK	0.82549903	4.35E-44
GBM	IUPHAR	CCL5	GZMA	0.844869833	4.73E-48
GBM	IUPHAR	CCL5	CD3E	0.845550205	3.35E-48
GBM	IUPHAR	CCL5	IL2RG	0.847677856	1.13E-48
GBM	IUPHAR	CCL5	CXCR6	0.84891633	5.99E-49
GBM	IUPHAR	CCL5	LCK	0.862064418	4.70E-52
GBM	IUPHAR	CCL5	CD2	0.875809418	1.15E-55
GBM	Kinase	CCL5	LCK	0.862064418	4.70E-52
KICH	CGC	CCL5	RHOH	0.831544281	1.90E-24
KICH	CGC	CCL5	PRF1	0.840022073	2.32E-25
KICH	IUPHAR	CCL5	CD2	0.811971995	1.60E-22
KICH	IUPHAR	CCL5	CD6	0.821280084	2.08E-23
KICH	IUPHAR	CCL5	ZAP70	0.830907874	2.21E-24
KICH	IUPHAR	CCL5	SLAMF7	0.832641115	1.45E-24
KICH	IUPHAR	CCL5	PRF1	0.840022073	2.32E-25
KICH	IUPHAR	CCL5	ITGAL	0.841394111	1.63E-25
KICH	IUPHAR	CCL5	PYHIN1	0.855977202	3.12E-27
KICH	IUPHAR	CCL5	CXCR3	0.863201087	3.72E-28
KICH	IUPHAR	CCL5	GZMK	0.867291626	1.06E-28
KICH	IUPHAR	CCL5	TIGIT	0.868173641	8.02E-29
KICH	IUPHAR	CCL5	CD3E	0.907853956	2.35E-35
KICH	IUPHAR	CCL5	GZMA	0.909171437	1.27E-35
KICH	IUPHAR	CCL5	CD247	0.935836626	4.41E-42
KICH	Kinase	CCL5	ZAP70	0.830907874	2.21E-24
KICH	TF	CCL5	TBX21	0.811223511	1.88E-22
KICH	TF	CCL5	RUNX3	0.831180283	2.07E-24
KICH	TSG	CCL5	RUNX3	0.831180283	2.07E-24
KICH	TSG	CCL5	PYHIN1	0.855977202	3.12E-27
KIRP	CGC	CCL5	WAS	0.800677957	2.09E-73
KIRP	CGC	CCL5	IKZF1	0.802530017	5.50E-74
KIRP	CGC	CCL5	ITK	0.840724491	1.58E-87
KIRP	CGC	CCL5	RHOH	0.853676362	5.87E-93
KIRP	CGC	CCL5	PRF1	0.879468596	1.60E-105
KIRP	CGC	CCL5	LCK	0.893993832	6.05E-114
KIRP	Epifactor	CCL5	IKZF1	0.802530017	5.50E-74
KIRP	Epifactor	CCL5	GFI1	0.811430647	7.31E-77
KIRP	IUPHAR	CCL5	ICOS	0.816438035	1.51E-78
KIRP	IUPHAR	CCL5	MAP4K1	0.817104401	8.90E-79
KIRP	IUPHAR	CCL5	GPR18	0.817436814	6.84E-79
KIRP	IUPHAR	CCL5	SLAMF7	0.818939514	2.07E-79
KIRP	IUPHAR	CCL5	LAG3	0.825962731	6.66E-82
KIRP	IUPHAR	CCL5	CD52	0.837239185	3.78E-86
KIRP	IUPHAR	CCL5	S1PR4	0.83986668	3.48E-87
KIRP	IUPHAR	CCL5	ITK	0.840724491	1.58E-87
KIRP	IUPHAR	CCL5	IL2RB	0.846497216	6.93E-90
KIRP	IUPHAR	CCL5	ZAP70	0.854843406	1.80E-93
KIRP	IUPHAR	CCL5	TIGIT	0.859119235	2.13E-95
KIRP	IUPHAR	CCL5	ITGAL	0.862927102	3.62E-97
KIRP	IUPHAR	CCL5	CD27	0.864199524	9.04E-98
KIRP	IUPHAR	CCL5	PRF1	0.879468596	1.60E-105
KIRP	IUPHAR	CCL5	CXCR6	0.882911519	2.04E-107
KIRP	IUPHAR	CCL5	PYHIN1	0.890056743	1.51E-111
KIRP	IUPHAR	CCL5	LCK	0.893993832	6.05E-114
KIRP	IUPHAR	CCL5	IL2RG	0.900224514	6.10E-118
KIRP	IUPHAR	CCL5	CD6	0.904369985	9.49E-121
KIRP	IUPHAR	CCL5	CXCR3	0.906420714	3.47E-122
KIRP	IUPHAR	CCL5	GZMK	0.914873458	1.76E-128
KIRP	IUPHAR	CCL5	CD247	0.931656235	3.47E-143
KIRP	IUPHAR	CCL5	CD2	0.939403313	2.69E-151
KIRP	IUPHAR	CCL5	GZMA	0.95120013	5.68E-166
KIRP	IUPHAR	CCL5	CD3E	0.954237716	2.41E-170
KIRP	Kinase	CCL5	MAP4K1	0.817104401	8.90E-79
KIRP	Kinase	CCL5	ITK	0.840724491	1.58E-87
KIRP	Kinase	CCL5	ZAP70	0.854843406	1.80E-93
KIRP	Kinase	CCL5	LCK	0.893993832	6.05E-114
KIRP	TF	CCL5	EOMES	0.80153724	1.13E-73
KIRP	TF	CCL5	IKZF1	0.802530017	5.50E-74
KIRP	TF	CCL5	ZNF831	0.804920944	9.60E-75
KIRP	TF	CCL5	GFI1	0.811430647	7.31E-77
KIRP	TF	CCL5	BATF	0.831613925	5.43E-84
KIRP	TF	CCL5	TBX21	0.864661099	5.44E-98
KIRP	TSG	CCL5	IKZF1	0.802530017	5.50E-74
KIRP	TSG	CCL5	MAP4K1	0.817104401	8.90E-79
KIRP	TSG	CCL5	PYHIN1	0.890056743	1.51E-111
LGG	CGC	CCL5	PRF1	0.830947554	1.46E-136
LGG	CGC	CCL5	LCK	0.865736853	7.72E-161
LGG	IUPHAR	CCL5	CCR2	0.80157355	4.95E-120
LGG	IUPHAR	CCL5	PRF1	0.830947554	1.46E-136
LGG	IUPHAR	CCL5	CXCR3	0.839853986	3.24E-142
LGG	IUPHAR	CCL5	IL2RB	0.842498942	5.82E-144
LGG	IUPHAR	CCL5	CXCR6	0.848008497	1.05E-147
LGG	IUPHAR	CCL5	LCK	0.865736853	7.72E-161
LGG	IUPHAR	CCL5	IL2RG	0.872327555	3.30E-166
LGG	IUPHAR	CCL5	GZMK	0.875502309	6.66E-169
LGG	IUPHAR	CCL5	GZMA	0.882394986	5.14E-175
LGG	IUPHAR	CCL5	CD2	0.911475075	7.71E-206
LGG	IUPHAR	CCL5	CD3E	0.937047786	2.05E-243
LGG	Kinase	CCL5	LCK	0.865736853	7.72E-161
LIHC	Cell metabolism gene	CCL5	PIK3CD	0.823049309	1.76E-105
LIHC	CGC	CCL5	WAS	0.817031156	1.01E-102
LIHC	CGC	CCL5	IKZF1	0.818243479	2.85E-103
LIHC	CGC	CCL5	PRF1	0.835825431	1.06E-111
LIHC	CGC	CCL5	LCK	0.886873501	2.89E-143
LIHC	Epifactor	CCL5	IKZF1	0.818243479	2.85E-103
LIHC	IUPHAR	CCL5	IL12RB1	0.80671951	3.16E-98
LIHC	IUPHAR	CCL5	CXCR3	0.807063428	2.26E-98
LIHC	IUPHAR	CCL5	PRKCQ	0.808317292	6.63E-99
LIHC	IUPHAR	CCL5	PIK3CD	0.823049309	1.76E-105
LIHC	IUPHAR	CCL5	CD52	0.832164265	7.26E-110
LIHC	IUPHAR	CCL5	MAP4K1	0.834876511	3.20E-111
LIHC	IUPHAR	CCL5	PRF1	0.835825431	1.06E-111
LIHC	IUPHAR	CCL5	S1PR4	0.837681614	1.19E-112
LIHC	IUPHAR	CCL5	CCR5	0.838618053	3.93E-113
LIHC	IUPHAR	CCL5	PYHIN1	0.838690513	3.61E-113
LIHC	IUPHAR	CCL5	ZAP70	0.840028385	7.27E-114
LIHC	IUPHAR	CCL5	TIGIT	0.848370287	2.37E-118
LIHC	IUPHAR	CCL5	SLAMF7	0.85043262	1.67E-119
LIHC	IUPHAR	CCL5	CXCR6	0.862879699	7.71E-127
LIHC	IUPHAR	CCL5	CD6	0.871953325	1.17E-132
LIHC	IUPHAR	CCL5	CD27	0.87371465	7.70E-134
LIHC	IUPHAR	CCL5	GZMK	0.876331038	1.26E-135
LIHC	IUPHAR	CCL5	CD2	0.884553746	1.60E-141
LIHC	IUPHAR	CCL5	LCK	0.886873501	2.89E-143
LIHC	IUPHAR	CCL5	CD247	0.887957587	4.29E-144
LIHC	IUPHAR	CCL5	CD3E	0.902284379	6.44E-156
LIHC	IUPHAR	CCL5	GZMA	0.938452649	1.80E-196
LIHC	Kinase	CCL5	PRKCQ	0.808317292	6.63E-99
LIHC	Kinase	CCL5	MAP4K1	0.834876511	3.20E-111
LIHC	Kinase	CCL5	ZAP70	0.840028385	7.27E-114
LIHC	Kinase	CCL5	LCK	0.886873501	2.89E-143
LIHC	TF	CCL5	IKZF1	0.818243479	2.85E-103
LIHC	TF	CCL5	ZNF831	0.818564509	2.04E-103
LIHC	TF	CCL5	RUNX3	0.821764642	6.95E-105
LIHC	TF	CCL5	TBX21	0.83801038	8.09E-113
LIHC	TSG	CCL5	TNFAIP8L2	0.801763804	3.68E-96
LIHC	TSG	CCL5	IKZF1	0.818243479	2.85E-103
LIHC	TSG	CCL5	RUNX3	0.821764642	6.95E-105
LIHC	TSG	CCL5	DOK2	0.82469173	2.98E-106
LIHC	TSG	CCL5	MAP4K1	0.834876511	3.20E-111
LIHC	TSG	CCL5	PYHIN1	0.838690513	3.61E-113
LUAD	CGC	CCL5	LCK	0.803550734	1.94E-131
LUAD	IUPHAR	CCL5	LCK	0.803550734	1.94E-131
LUAD	IUPHAR	CCL5	PYHIN1	0.846876694	1.47E-159
LUAD	IUPHAR	CCL5	CXCR6	0.852148167	1.43E-163
LUAD	IUPHAR	CCL5	CD2	0.859414526	2.28E-169
LUAD	IUPHAR	CCL5	CD247	0.866386731	3.02E-175
LUAD	IUPHAR	CCL5	CD3E	0.870919669	3.01E-179
LUAD	IUPHAR	CCL5	GZMA	0.900425657	1.16E-209
LUAD	Kinase	CCL5	LCK	0.803550734	1.94E-131
LUAD	TF	CCL5	ZNF683	0.815833444	1.20E-138
LUAD	TSG	CCL5	PYHIN1	0.846876694	1.47E-159
LUSC	CGC	CCL5	PRF1	0.813016425	1.56E-131
LUSC	IUPHAR	CCL5	CXCR3	0.804914708	5.44E-127
LUSC	IUPHAR	CCL5	CCR5	0.808602108	4.95E-129
LUSC	IUPHAR	CCL5	PRF1	0.813016425	1.56E-131
LUSC	IUPHAR	CCL5	CXCR6	0.825241579	7.94E-139
LUSC	IUPHAR	CCL5	IL2RG	0.841315914	2.49E-149
LUSC	IUPHAR	CCL5	CD2	0.856345001	2.85E-160
LUSC	IUPHAR	CCL5	CD3E	0.857781098	2.21E-161
MESO	CGC	CCL5	LCK	0.822337611	1.60E-22
MESO	CGC	CCL5	PRF1	0.82409457	1.09E-22
MESO	Epifactor	CCL5	APOBEC3H	0.842719585	1.41E-24
MESO	IUPHAR	CCL5	ITGAL	0.801109546	1.21E-20
MESO	IUPHAR	CCL5	TIGIT	0.810416265	1.94E-21
MESO	IUPHAR	CCL5	ITGB7	0.820135582	2.57E-22
MESO	IUPHAR	CCL5	LCK	0.822337611	1.60E-22
MESO	IUPHAR	CCL5	PRF1	0.82409457	1.09E-22
MESO	IUPHAR	CCL5	IL2RG	0.836668004	6.14E-24
MESO	IUPHAR	CCL5	CXCR6	0.844101875	9.98E-25
MESO	IUPHAR	CCL5	CD3E	0.85097687	1.71E-25
MESO	IUPHAR	CCL5	GZMK	0.861639575	9.17E-27
MESO	IUPHAR	CCL5	CXCR3	0.86377781	4.96E-27
MESO	IUPHAR	CCL5	CD2	0.870608598	6.45E-28
MESO	IUPHAR	CCL5	GZMA	0.876625259	9.71E-29
MESO	IUPHAR	CCL5	CD247	0.885719858	4.56E-30
MESO	Kinase	CCL5	LCK	0.822337611	1.60E-22
MESO	TF	CCL5	EOMES	0.803840919	7.12E-21
MESO	TF	CCL5	TBX21	0.819655542	2.84E-22
OV	Cell metabolism gene	CCL5	TYMP	0.832327369	2.09E-80
OV	CGC	CCL5	WAS	0.820151358	3.48E-76
OV	CGC	CCL5	PDCD1LG2	0.821117152	1.65E-76
OV	CGC	CCL5	IL21R	0.858831906	6.73E-91
OV	CGC	CCL5	PTPRC	0.861029605	7.29E-92
OV	CGC	CCL5	RHOH	0.864023357	3.32E-93
OV	CGC	CCL5	PRF1	0.893161394	3.26E-108
OV	CGC	CCL5	ITK	0.901713853	1.84E-113
OV	IUPHAR	CCL5	CTSS	0.800356164	5.80E-70
OV	IUPHAR	CCL5	LAIR1	0.803618146	6.13E-71
OV	IUPHAR	CCL5	CD27	0.80616355	1.03E-71
OV	IUPHAR	CCL5	HAVCR2	0.810038342	6.48E-73
OV	IUPHAR	CCL5	CD86	0.822186463	7.22E-77
OV	IUPHAR	CCL5	CTLA4	0.826487796	2.43E-78
OV	IUPHAR	CCL5	FCER1G	0.832660369	1.58E-80
OV	IUPHAR	CCL5	CD37	0.832702583	1.53E-80
OV	IUPHAR	CCL5	PTPN22	0.841998619	5.21E-84
OV	IUPHAR	CCL5	SLAMF7	0.847125137	5.10E-86
OV	IUPHAR	CCL5	PYHIN1	0.854011241	7.74E-89
OV	IUPHAR	CCL5	ITGAL	0.855148258	2.57E-89
OV	IUPHAR	CCL5	IL12RB1	0.857229278	3.32E-90
OV	IUPHAR	CCL5	P2RY10	0.857765679	1.95E-90
OV	IUPHAR	CCL5	GZMK	0.858131953	1.35E-90
OV	IUPHAR	CCL5	IL21R	0.858831906	6.73E-91
OV	IUPHAR	CCL5	PTPRC	0.861029605	7.29E-92
OV	IUPHAR	CCL5	TIGIT	0.870711139	2.54E-96
OV	IUPHAR	CCL5	ICOS	0.872723419	2.71E-97
OV	IUPHAR	CCL5	CCR5	0.887839023	3.62E-105
OV	IUPHAR	CCL5	GPR171	0.888888891	9.33E-106
OV	IUPHAR	CCL5	CD247	0.891876195	1.83E-107
OV	IUPHAR	CCL5	PRF1	0.893161394	3.26E-108
OV	IUPHAR	CCL5	ITK	0.901713853	1.84E-113
OV	IUPHAR	CCL5	IL2RB	0.902962197	2.87E-114
OV	IUPHAR	CCL5	CXCR3	0.908874337	3.05E-118
OV	IUPHAR	CCL5	CXCR6	0.91874413	1.60E-125
OV	IUPHAR	CCL5	GZMA	0.932382484	2.89E-137
OV	IUPHAR	CCL5	IL2RG	0.939430359	2.43E-144
OV	IUPHAR	CCL5	CD2	0.941801246	6.48E-147
OV	IUPHAR	CCL5	CD3E	0.949861831	1.50E-156
OV	Kinase	CCL5	ITK	0.901713853	1.84E-113
OV	TF	CCL5	SPI1	0.814366635	2.73E-74
OV	TF	CCL5	TBX21	0.878477341	3.63E-100
OV	TF	CCL5	ZNF683	0.882624366	2.49E-102
OV	TSG	CCL5	SPI1	0.814366635	2.73E-74
OV	TSG	CCL5	PYHIN1	0.854011241	7.74E-89
OV	TSG	CCL5	PTPRC	0.861029605	7.29E-92
PAAD	CGC	CCL5	BTK	0.800814177	3.72E-42
PAAD	CGC	CCL5	ITK	0.809561465	9.80E-44
PAAD	CGC	CCL5	WAS	0.824300375	1.37E-46
PAAD	CGC	CCL5	IKZF1	0.832537415	2.64E-48
PAAD	CGC	CCL5	PRF1	0.851918033	9.80E-53
PAAD	Epifactor	CCL5	IKZF1	0.832537415	2.64E-48
PAAD	IUPHAR	CCL5	BTK	0.800814177	3.72E-42
PAAD	IUPHAR	CCL5	IL10RA	0.801075881	3.34E-42
PAAD	IUPHAR	CCL5	P2RY10	0.809137776	1.17E-43
PAAD	IUPHAR	CCL5	ITK	0.809561465	9.80E-44
PAAD	IUPHAR	CCL5	GPR65	0.811276338	4.70E-44
PAAD	IUPHAR	CCL5	PDCD1	0.812731882	2.50E-44
PAAD	IUPHAR	CCL5	ZAP70	0.817208986	3.48E-45
PAAD	IUPHAR	CCL5	ICOS	0.819475186	1.26E-45
PAAD	IUPHAR	CCL5	CD6	0.826235562	5.52E-47
PAAD	IUPHAR	CCL5	MAP4K1	0.833219499	1.89E-48
PAAD	IUPHAR	CCL5	GZMA	0.834475103	1.01E-48
PAAD	IUPHAR	CCL5	GPR171	0.835773724	5.28E-49
PAAD	IUPHAR	CCL5	IL2RB	0.839542027	7.74E-50
PAAD	IUPHAR	CCL5	CD27	0.840184931	5.55E-50
PAAD	IUPHAR	CCL5	TIGIT	0.847924122	9.01E-52
PAAD	IUPHAR	CCL5	PRF1	0.851918033	9.80E-53
PAAD	IUPHAR	CCL5	PYHIN1	0.861569798	3.48E-55
PAAD	IUPHAR	CCL5	ITGAL	0.865887935	2.43E-56
PAAD	IUPHAR	CCL5	GZMK	0.866189026	2.01E-56
PAAD	IUPHAR	CCL5	CCR5	0.876721396	1.98E-59
PAAD	IUPHAR	CCL5	CXCR6	0.885902671	2.77E-62
PAAD	IUPHAR	CCL5	CD247	0.889131463	2.40E-63
PAAD	IUPHAR	CCL5	CD3E	0.906584025	1.00E-69
PAAD	IUPHAR	CCL5	CD2	0.926455966	9.97E-79
PAAD	Kinase	CCL5	BTK	0.800814177	3.72E-42
PAAD	Kinase	CCL5	ITK	0.809561465	9.80E-44
PAAD	Kinase	CCL5	ZAP70	0.817208986	3.48E-45
PAAD	Kinase	CCL5	MAP4K1	0.833219499	1.89E-48
PAAD	TF	CCL5	EOMES	0.81017466	7.54E-44
PAAD	TF	CCL5	IKZF1	0.832537415	2.64E-48
PAAD	TF	CCL5	TBX21	0.874068827	1.20E-58
PAAD	TSG	CCL5	BTK	0.800814177	3.72E-42
PAAD	TSG	CCL5	IKZF1	0.832537415	2.64E-48
PAAD	TSG	CCL5	MAP4K1	0.833219499	1.89E-48
PAAD	TSG	CCL5	PYHIN1	0.861569798	3.48E-55
PCPG	CGC	CCL5	LCK	0.839867198	5.62E-51
PCPG	IUPHAR	CCL5	GZMK	0.801350413	3.79E-43
PCPG	IUPHAR	CCL5	ZAP70	0.805979875	5.39E-44
PCPG	IUPHAR	CCL5	CXCR3	0.821105051	6.29E-47
PCPG	IUPHAR	CCL5	CD247	0.838290982	1.29E-50
PCPG	IUPHAR	CCL5	LCK	0.839867198	5.62E-51
PCPG	IUPHAR	CCL5	CD6	0.842363453	1.49E-51
PCPG	IUPHAR	CCL5	ITGAL	0.857636891	2.52E-55
PCPG	IUPHAR	CCL5	CD52	0.872525983	1.89E-59
PCPG	IUPHAR	CCL5	CD2	0.882665865	1.44E-62
PCPG	IUPHAR	CCL5	GZMA	0.902099022	1.94E-69
PCPG	IUPHAR	CCL5	IL2RG	0.902103181	1.94E-69
PCPG	IUPHAR	CCL5	CD3E	0.902297998	1.63E-69
PCPG	Kinase	CCL5	ZAP70	0.805979875	5.39E-44
PCPG	Kinase	CCL5	LCK	0.839867198	5.62E-51
PRAD	CGC	CCL5	PRF1	0.890418785	1.77E-189
PRAD	Epifactor	CCL5	SCML4	0.830322689	2.90E-141
PRAD	IUPHAR	CCL5	S1PR4	0.801216693	2.57E-124
PRAD	IUPHAR	CCL5	CCR5	0.802491358	5.34E-125
PRAD	IUPHAR	CCL5	MAP4K1	0.804741699	3.24E-126
PRAD	IUPHAR	CCL5	CD27	0.815360483	3.54E-132
PRAD	IUPHAR	CCL5	IL2RG	0.825463141	3.23E-138
PRAD	IUPHAR	CCL5	ITGAL	0.834062063	1.13E-143
PRAD	IUPHAR	CCL5	CD6	0.835421925	1.44E-144
PRAD	IUPHAR	CCL5	GZMK	0.838768665	8.51E-147
PRAD	IUPHAR	CCL5	CXCR3	0.846167245	6.52E-152
PRAD	IUPHAR	CCL5	CXCR6	0.851893134	4.63E-156
PRAD	IUPHAR	CCL5	PRF1	0.890418785	1.77E-189
PRAD	IUPHAR	CCL5	CD247	0.892506991	1.22E-191
PRAD	IUPHAR	CCL5	GZMA	0.896131989	1.71E-195
PRAD	IUPHAR	CCL5	CD2	0.915940493	1.90E-219
PRAD	IUPHAR	CCL5	CD3E	0.93608005	8.36E-251
PRAD	Kinase	CCL5	MAP4K1	0.804741699	3.24E-126
PRAD	TF	CCL5	TBX21	0.824837562	7.83E-138
PRAD	TF	CCL5	SCML4	0.830322689	2.90E-141
PRAD	TSG	CCL5	MAP4K1	0.804741699	3.24E-126
READ	CGC	CCL5	WAS	0.817706796	1.88E-26
READ	IUPHAR	CCL5	MAP4K1	0.805878096	3.48E-25
READ	IUPHAR	CCL5	GZMK	0.806511316	2.99E-25
READ	IUPHAR	CCL5	PYHIN1	0.808508494	1.85E-25
READ	IUPHAR	CCL5	CD2	0.811666672	8.57E-26
READ	IUPHAR	CCL5	ITGAL	0.819239965	1.27E-26
READ	IUPHAR	CCL5	CD247	0.820320547	9.61E-27
READ	IUPHAR	CCL5	GZMA	0.830140354	6.94E-28
READ	IUPHAR	CCL5	LAG3	0.832612697	3.48E-28
READ	IUPHAR	CCL5	CD3E	0.837396147	8.90E-29
READ	Kinase	CCL5	MAP4K1	0.805878096	3.48E-25
READ	TF	CCL5	TBX21	0.804724815	4.57E-25
READ	TSG	CCL5	MAP4K1	0.805878096	3.48E-25
READ	TSG	CCL5	PYHIN1	0.808508494	1.85E-25
SKCM	Cell metabolism gene	CCL5	CD38	0.80632244	1.03E-109
SKCM	Cell metabolism gene	CCL5	IDO1	0.807171261	4.07E-110
SKCM	Cell metabolism gene	CCL5	IL4I1	0.820915181	6.31E-117
SKCM	Cell metabolism gene	CCL5	PLA2G2D	0.822339232	1.15E-117
SKCM	Cell metabolism gene	CCL5	PSMB9	0.835198746	1.19E-124
SKCM	Cell metabolism gene	CCL5	GNGT2	0.877342575	1.29E-152
SKCM	CGC	CCL5	SOCS1	0.806924988	5.33E-110
SKCM	CGC	CCL5	ITK	0.810980225	6.01E-112
SKCM	CGC	CCL5	CARD11	0.82350153	2.84E-118
SKCM	CGC	CCL5	RHOH	0.828174802	9.18E-121
SKCM	CGC	CCL5	CIITA	0.834480248	3.02E-124
SKCM	CGC	CCL5	IKZF1	0.842981624	3.51E-129
SKCM	CGC	CCL5	VAV1	0.846100781	4.58E-131
SKCM	CGC	CCL5	IL21R	0.849877777	2.10E-133
SKCM	CGC	CCL5	PTPN6	0.866271101	2.32E-144
SKCM	CGC	CCL5	WAS	0.867062796	6.32E-145
SKCM	CGC	CCL5	CD74	0.888998565	3.19E-162
SKCM	CGC	CCL5	LCK	0.912986963	6.76E-186
SKCM	CGC	CCL5	PRF1	0.923355331	2.37E-198
SKCM	Epifactor	CCL5	SP140	0.822186389	1.38E-117
SKCM	Epifactor	CCL5	IKZF1	0.842981624	3.51E-129
SKCM	IUPHAR	CCL5	CD37	0.803301745	2.68E-108
SKCM	IUPHAR	CCL5	NLRC5	0.804397246	8.27E-109
SKCM	IUPHAR	CCL5	CD38	0.80632244	1.03E-109
SKCM	IUPHAR	CCL5	IDO1	0.807171261	4.07E-110
SKCM	IUPHAR	CCL5	ICOS	0.807301686	3.53E-110
SKCM	IUPHAR	CCL5	ITK	0.810980225	6.01E-112
SKCM	IUPHAR	CCL5	LAIR1	0.810997448	5.89E-112
SKCM	IUPHAR	CCL5	INPP5D	0.813049051	5.84E-113
SKCM	IUPHAR	CCL5	P2RY10	0.817930801	2.13E-115
SKCM	IUPHAR	CCL5	CD86	0.81905413	5.70E-116
SKCM	IUPHAR	CCL5	SP140	0.822186389	1.38E-117
SKCM	IUPHAR	CCL5	PLA2G2D	0.822339232	1.15E-117
SKCM	IUPHAR	CCL5	CCRL2	0.82308104	4.72E-118
SKCM	IUPHAR	CCL5	HCK	0.824080639	1.41E-118
SKCM	IUPHAR	CCL5	CLEC4E	0.825143656	3.86E-119
SKCM	IUPHAR	CCL5	CD52	0.82861884	5.28E-121
SKCM	IUPHAR	CCL5	TNFRSF9	0.829745832	1.28E-121
SKCM	IUPHAR	CCL5	ITGB2	0.83103988	2.50E-122
SKCM	IUPHAR	CCL5	CIITA	0.834480248	3.02E-124
SKCM	IUPHAR	CCL5	PSMB9	0.835198746	1.19E-124
SKCM	IUPHAR	CCL5	S1PR4	0.836848027	1.36E-125
SKCM	IUPHAR	CCL5	TNFRSF1B	0.838634363	1.27E-126
SKCM	IUPHAR	CCL5	IL15RA	0.839096836	6.86E-127
SKCM	IUPHAR	CCL5	P2RY6	0.847062347	1.18E-131
SKCM	IUPHAR	CCL5	HAVCR2	0.84917509	5.78E-133
SKCM	IUPHAR	CCL5	IL21R	0.849877777	2.10E-133
SKCM	IUPHAR	CCL5	IL10RA	0.853047094	2.04E-135
SKCM	IUPHAR	CCL5	CD6	0.869057305	2.29E-146
SKCM	IUPHAR	CCL5	IL12RB1	0.87846916	1.68E-153
SKCM	IUPHAR	CCL5	GPR171	0.88378779	8.42E-158
SKCM	IUPHAR	CCL5	CD74	0.888998565	3.19E-162
SKCM	IUPHAR	CCL5	IL2RB	0.889266721	1.86E-162
SKCM	IUPHAR	CCL5	CCR5	0.894628146	2.96E-167
SKCM	IUPHAR	CCL5	CD247	0.895387008	5.91E-168
SKCM	IUPHAR	CCL5	GZMK	0.897456914	6.82E-170
SKCM	IUPHAR	CCL5	TIGIT	0.904782449	4.25E-177
SKCM	IUPHAR	CCL5	CD27	0.908916072	2.00E-181
SKCM	IUPHAR	CCL5	ITGAL	0.912213516	4.97E-185
SKCM	IUPHAR	CCL5	LCK	0.912986963	6.76E-186
SKCM	IUPHAR	CCL5	LAG3	0.922090601	9.67E-197
SKCM	IUPHAR	CCL5	IL2RG	0.922243392	6.20E-197
SKCM	IUPHAR	CCL5	CXCR6	0.922898959	9.11E-198
SKCM	IUPHAR	CCL5	PRF1	0.923355331	2.37E-198
SKCM	IUPHAR	CCL5	CD3E	0.927280133	1.56E-203
SKCM	IUPHAR	CCL5	PDCD1	0.928242985	7.57E-205
SKCM	IUPHAR	CCL5	CXCR3	0.932772287	2.72E-211
SKCM	IUPHAR	CCL5	CD2	0.933405246	3.15E-212
SKCM	IUPHAR	CCL5	GZMA	0.935803225	7.34E-216
SKCM	Kinase	CCL5	ITK	0.810980225	6.01E-112
SKCM	Kinase	CCL5	HCK	0.824080639	1.41E-118
SKCM	Kinase	CCL5	LCK	0.912986963	6.76E-186
SKCM	TF	CCL5	ETV7	0.808421801	1.03E-110
SKCM	TF	CCL5	ZNF683	0.818752318	8.13E-116
SKCM	TF	CCL5	SP140	0.822186389	1.38E-117
SKCM	TF	CCL5	ZBED2	0.834611667	2.55E-124
SKCM	TF	CCL5	ASCL2	0.840498885	1.04E-127
SKCM	TF	CCL5	SPI1	0.840666886	8.28E-128
SKCM	TF	CCL5	IKZF1	0.842981624	3.51E-129
SKCM	TF	CCL5	IRF1	0.900219426	1.52E-172
SKCM	TF	CCL5	TBX21	0.919412494	2.03E-193
SKCM	TSG	CCL5	SOCS1	0.806924988	5.33E-110
SKCM	TSG	CCL5	AIF1	0.833082183	1.84E-123
SKCM	TSG	CCL5	SPI1	0.840666886	8.28E-128
SKCM	TSG	CCL5	IKZF1	0.842981624	3.51E-129
SKCM	TSG	CCL5	RARRES3	0.845842434	6.59E-131
SKCM	TSG	CCL5	TNFAIP8L2	0.847352957	7.81E-132
SKCM	TSG	CCL5	DOK2	0.85105328	3.81E-134
SKCM	TSG	CCL5	PTPN6	0.866271101	2.32E-144
SKCM	TSG	CCL5	IRF1	0.900219426	1.52E-172
STAD	CGC	CCL5	PRF1	0.830541854	6.08E-116
STAD	Epifactor	CCL5	APOBEC3G	0.806856212	1.81E-104
STAD	Epifactor	CCL5	APOBEC3H	0.817740554	1.56E-109
STAD	IUPHAR	CCL5	TIGIT	0.806830794	1.86E-104
STAD	IUPHAR	CCL5	IL2RB	0.813617487	1.41E-107
STAD	IUPHAR	CCL5	PYHIN1	0.819434693	2.37E-110
STAD	IUPHAR	CCL5	GZMK	0.826058904	1.22E-113
STAD	IUPHAR	CCL5	PRF1	0.830541854	6.08E-116
STAD	IUPHAR	CCL5	LAG3	0.831996436	1.05E-116
STAD	IUPHAR	CCL5	CD247	0.84024066	3.63E-121
STAD	IUPHAR	CCL5	GPR171	0.846434309	1.09E-124
STAD	IUPHAR	CCL5	CXCR6	0.854246266	2.31E-129
STAD	IUPHAR	CCL5	CCR5	0.863426093	3.25E-135
STAD	IUPHAR	CCL5	GZMA	0.872000284	4.43E-141
STAD	IUPHAR	CCL5	CD2	0.883659348	8.99E-150
STAD	IUPHAR	CCL5	CD3E	0.886946498	2.16E-152
STAD	TF	CCL5	ZNF683	0.80186222	2.98E-102
STAD	TF	CCL5	TBX21	0.851116486	1.86E-127
STAD	TSG	CCL5	PYHIN1	0.819434693	2.37E-110
TGCT	Cell metabolism gene	CCL5	KMO	0.802401895	2.38E-36
TGCT	Cell metabolism gene	CCL5	PSMB8	0.803648807	1.54E-36
TGCT	Cell metabolism gene	CCL5	IDO1	0.816137349	1.64E-38
TGCT	Cell metabolism gene	CCL5	PSMB10	0.816956571	1.20E-38
TGCT	Cell metabolism gene	CCL5	TYMP	0.823396185	9.94E-40
TGCT	Cell metabolism gene	CCL5	PLA2G2D	0.831937013	3.10E-41
TGCT	Cell metabolism gene	CCL5	IL4I1	0.842921221	2.66E-43
TGCT	Cell metabolism gene	CCL5	GNGT2	0.862652837	1.92E-47
TGCT	Cell metabolism gene	CCL5	PSMB9	0.904343719	8.05E-59
TGCT	CGC	CCL5	PTPRC	0.803860865	1.43E-36
TGCT	CGC	CCL5	B2M	0.80871969	2.54E-37
TGCT	CGC	CCL5	CD79A	0.80888032	2.39E-37
TGCT	CGC	CCL5	IRF4	0.809244753	2.10E-37
TGCT	CGC	CCL5	BTK	0.826905461	2.45E-40
TGCT	CGC	CCL5	RHOH	0.840986423	6.32E-43
TGCT	CGC	CCL5	CIITA	0.844156781	1.53E-43
TGCT	CGC	CCL5	PDCD1LG2	0.85005532	9.93E-45
TGCT	CGC	CCL5	PRF1	0.850742852	7.17E-45
TGCT	CGC	CCL5	ITK	0.85685866	3.66E-46
TGCT	CGC	CCL5	VAV1	0.860366658	6.24E-47
TGCT	CGC	CCL5	JAK3	0.866974174	1.95E-48
TGCT	CGC	CCL5	CD74	0.868782366	7.30E-49
TGCT	CGC	CCL5	P2RY8	0.873070216	6.71E-50
TGCT	CGC	CCL5	BIRC3	0.884071071	9.67E-53
TGCT	CGC	CCL5	IL21R	0.886270627	2.41E-53
TGCT	CGC	CCL5	IKZF1	0.902866472	2.47E-58
TGCT	CGC	CCL5	WAS	0.927103744	1.61E-67
TGCT	Epifactor	CCL5	SP140	0.87330333	5.88E-50
TGCT	Epifactor	CCL5	GFI1	0.884402428	7.86E-53
TGCT	Epifactor	CCL5	IKZF1	0.902866472	2.47E-58
TGCT	IUPHAR	CCL5	KMO	0.802401895	2.38E-36
TGCT	IUPHAR	CCL5	CXCR5	0.802875945	2.02E-36
TGCT	IUPHAR	CCL5	PSMB8	0.803648807	1.54E-36
TGCT	IUPHAR	CCL5	PTPRC	0.803860865	1.43E-36
TGCT	IUPHAR	CCL5	HCK	0.807361328	4.14E-37
TGCT	IUPHAR	CCL5	ITGAX	0.807516364	3.91E-37
TGCT	IUPHAR	CCL5	LY96	0.809320147	2.04E-37
TGCT	IUPHAR	CCL5	TAP2	0.811572005	8.98E-38
TGCT	IUPHAR	CCL5	GPR132	0.815799962	1.86E-38
TGCT	IUPHAR	CCL5	LAIR1	0.815832531	1.84E-38
TGCT	IUPHAR	CCL5	IDO1	0.816137349	1.64E-38
TGCT	IUPHAR	CCL5	SLC15A3	0.816687591	1.33E-38
TGCT	IUPHAR	CCL5	CCR2	0.819685923	4.23E-39
TGCT	IUPHAR	CCL5	AIM2	0.820095665	3.61E-39
TGCT	IUPHAR	CCL5	CD40	0.820161407	3.52E-39
TGCT	IUPHAR	CCL5	ITGB2	0.822864666	1.23E-39
TGCT	IUPHAR	CCL5	HAVCR2	0.823356559	1.01E-39
TGCT	IUPHAR	CCL5	CLEC4E	0.826197623	3.26E-40
TGCT	IUPHAR	CCL5	BTK	0.826905461	2.45E-40
TGCT	IUPHAR	CCL5	IL2RB	0.826927318	2.43E-40
TGCT	IUPHAR	CCL5	CSF2RB	0.82872365	1.17E-40
TGCT	IUPHAR	CCL5	IL15RA	0.83001697	6.88E-41
TGCT	IUPHAR	CCL5	PLA2G2D	0.831937013	3.10E-41
TGCT	IUPHAR	CCL5	P2RY10	0.834872472	9.00E-42
TGCT	IUPHAR	CCL5	FGR	0.837503145	2.91E-42
TGCT	IUPHAR	CCL5	FCER1G	0.838409333	1.96E-42
TGCT	IUPHAR	CCL5	CIITA	0.844156781	1.53E-43
TGCT	IUPHAR	CCL5	NLRC5	0.847302335	3.60E-44
TGCT	IUPHAR	CCL5	PRF1	0.850742852	7.17E-45
TGCT	IUPHAR	CCL5	LAG3	0.856698798	3.96E-46
TGCT	IUPHAR	CCL5	ITK	0.85685866	3.66E-46
TGCT	IUPHAR	CCL5	PTPN22	0.859186164	1.14E-46
TGCT	IUPHAR	CCL5	CD86	0.859656634	8.96E-47
TGCT	IUPHAR	CCL5	LILRB1	0.861932129	2.79E-47
TGCT	IUPHAR	CCL5	MCOLN2	0.864680513	6.62E-48
TGCT	IUPHAR	CCL5	JAK3	0.866974174	1.95E-48
TGCT	IUPHAR	CCL5	CD74	0.868782366	7.30E-49
TGCT	IUPHAR	CCL5	ICOS	0.870226193	3.30E-49
TGCT	IUPHAR	CCL5	P2RY8	0.873070216	6.71E-50
TGCT	IUPHAR	CCL5	SP140	0.87330333	5.88E-50
TGCT	IUPHAR	CCL5	NLRC3	0.873957239	4.05E-50
TGCT	IUPHAR	CCL5	TNFRSF1B	0.87436339	3.21E-50
TGCT	IUPHAR	CCL5	GPR65	0.882795301	2.14E-52
TGCT	IUPHAR	CCL5	BIRC3	0.884071071	9.67E-53
TGCT	IUPHAR	CCL5	CD37	0.885475668	4.00E-53
TGCT	IUPHAR	CCL5	GPR171	0.88577625	3.31E-53
TGCT	IUPHAR	CCL5	IL21R	0.886270627	2.41E-53
TGCT	IUPHAR	CCL5	TIGIT	0.890467534	1.58E-54
TGCT	IUPHAR	CCL5	GPR18	0.89096468	1.13E-54
TGCT	IUPHAR	CCL5	IL10RA	0.892759606	3.39E-55
TGCT	IUPHAR	CCL5	SLAMF7	0.893564445	1.96E-55
TGCT	IUPHAR	CCL5	CTLA4	0.895958231	3.74E-56
TGCT	IUPHAR	CCL5	IL12RB1	0.899891718	2.24E-57
TGCT	IUPHAR	CCL5	CD52	0.900950792	1.03E-57
TGCT	IUPHAR	CCL5	PSMB9	0.904343719	8.05E-59
TGCT	IUPHAR	CCL5	TAP1	0.905242107	4.03E-59
TGCT	IUPHAR	CCL5	PYHIN1	0.909805259	1.08E-60
TGCT	IUPHAR	CCL5	CXCR6	0.910241911	7.55E-61
TGCT	IUPHAR	CCL5	CCR5	0.913684263	4.26E-62
TGCT	IUPHAR	CCL5	CD27	0.920349613	1.13E-64
TGCT	IUPHAR	CCL5	S1PR4	0.92438661	2.42E-66
TGCT	IUPHAR	CCL5	ITGB7	0.926224778	3.91E-67
TGCT	IUPHAR	CCL5	ITGAL	0.926297872	3.63E-67
TGCT	IUPHAR	CCL5	IL2RG	0.926346152	3.46E-67
TGCT	IUPHAR	CCL5	CD6	0.928292911	4.74E-68
TGCT	IUPHAR	CCL5	PDCD1	0.930355836	5.43E-69
TGCT	IUPHAR	CCL5	GZMK	0.9391296	2.40E-73
TGCT	IUPHAR	CCL5	CD247	0.94034535	5.31E-74
TGCT	IUPHAR	CCL5	CD2	0.94811875	1.54E-78
TGCT	IUPHAR	CCL5	GZMA	0.94867694	6.82E-79
TGCT	IUPHAR	CCL5	CD3E	0.956371129	3.40E-84
TGCT	IUPHAR	CCL5	CXCR3	0.956769446	1.70E-84
TGCT	Kinase	CCL5	HCK	0.807361328	4.14E-37
TGCT	Kinase	CCL5	BTK	0.826905461	2.45E-40
TGCT	Kinase	CCL5	FGR	0.837503145	2.91E-42
TGCT	Kinase	CCL5	ITK	0.85685866	3.66E-46
TGCT	Kinase	CCL5	JAK3	0.866974174	1.95E-48
TGCT	TF	CCL5	IRF4	0.809244753	2.10E-37
TGCT	TF	CCL5	ZBED2	0.815122133	2.40E-38
TGCT	TF	CCL5	ARID5A	0.833676947	1.49E-41
TGCT	TF	CCL5	SPI1	0.835358481	7.32E-42
TGCT	TF	CCL5	ZNF831	0.865392077	4.54E-48
TGCT	TF	CCL5	SP140	0.87330333	5.88E-50
TGCT	TF	CCL5	GFI1	0.884402428	7.86E-53
TGCT	TF	CCL5	IRF1	0.886536502	2.04E-53
TGCT	TF	CCL5	RUNX3	0.88676679	1.76E-53
TGCT	TF	CCL5	IKZF1	0.902866472	2.47E-58
TGCT	TF	CCL5	BATF	0.920299773	1.19E-64
TGCT	TF	CCL5	TBX21	0.932677863	4.36E-70
TGCT	TSG	CCL5	PTPRC	0.803860865	1.43E-36
TGCT	TSG	CCL5	LAT2	0.809237876	2.10E-37
TGCT	TSG	CCL5	IRF4	0.809244753	2.10E-37
TGCT	TSG	CCL5	AIM2	0.820095665	3.61E-39
TGCT	TSG	CCL5	BTK	0.826905461	2.45E-40
TGCT	TSG	CCL5	SPI1	0.835358481	7.32E-42
TGCT	TSG	CCL5	RARRES3	0.849664659	1.19E-44
TGCT	TSG	CCL5	DENND2D	0.861501698	3.48E-47
TGCT	TSG	CCL5	TNFAIP8L2	0.866857892	2.07E-48
TGCT	TSG	CCL5	DOK2	0.875196272	1.99E-50
TGCT	TSG	CCL5	IRF1	0.886536502	2.04E-53
TGCT	TSG	CCL5	RUNX3	0.88676679	1.76E-53
TGCT	TSG	CCL5	IKZF1	0.902866472	2.47E-58
TGCT	TSG	CCL5	PYHIN1	0.909805259	1.08E-60
THCA	CGC	CCL5	CD79A	0.82447564	4.65E-143
THCA	CGC	CCL5	RHOH	0.851294752	8.65E-162
THCA	CGC	CCL5	WAS	0.855544404	4.27E-165
THCA	CGC	CCL5	ITK	0.856726862	4.91E-166
THCA	CGC	CCL5	IKZF1	0.86082859	2.33E-169
THCA	CGC	CCL5	PRF1	0.863450238	1.53E-171
THCA	CGC	CCL5	LCK	0.866869721	1.87E-174
THCA	Epifactor	CCL5	GFI1	0.831816422	7.47E-148
THCA	Epifactor	CCL5	SP140	0.845185949	3.27E-157
THCA	Epifactor	CCL5	IKZF1	0.86082859	2.33E-169
THCA	Epifactor	CCL5	SCML4	0.876989454	1.42E-183
THCA	IUPHAR	CCL5	IL10RA	0.801429718	2.38E-129
THCA	IUPHAR	CCL5	GPR65	0.803545972	1.56E-130
THCA	IUPHAR	CCL5	CASP1	0.803714311	1.26E-130
THCA	IUPHAR	CCL5	P2RY10	0.806485614	3.37E-132
THCA	IUPHAR	CCL5	ICOS	0.808727022	1.73E-133
THCA	IUPHAR	CCL5	AIM2	0.823548506	1.81E-142
THCA	IUPHAR	CCL5	CD37	0.826131506	4.04E-144
THCA	IUPHAR	CCL5	TIGIT	0.841125561	2.80E-154
THCA	IUPHAR	CCL5	GPR171	0.84173057	1.04E-154
THCA	IUPHAR	CCL5	SP140	0.845185949	3.27E-157
THCA	IUPHAR	CCL5	IL12RB1	0.846538401	3.30E-158
THCA	IUPHAR	CCL5	ITK	0.856726862	4.91E-166
THCA	IUPHAR	CCL5	PRF1	0.863450238	1.53E-171
THCA	IUPHAR	CCL5	LCK	0.866869721	1.87E-174
THCA	IUPHAR	CCL5	CCR5	0.867348161	7.21E-175
THCA	IUPHAR	CCL5	LAG3	0.870712404	7.93E-178
THCA	IUPHAR	CCL5	SLAMF7	0.873144698	5.11E-180
THCA	IUPHAR	CCL5	CD6	0.879749267	3.33E-186
THCA	IUPHAR	CCL5	ZAP70	0.883654875	4.91E-190
THCA	IUPHAR	CCL5	ITGAL	0.886608587	5.02E-193
THCA	IUPHAR	CCL5	PYHIN1	0.890077521	1.20E-196
THCA	IUPHAR	CCL5	IL2RG	0.894692716	1.18E-201
THCA	IUPHAR	CCL5	GZMK	0.896829775	4.70E-204
THCA	IUPHAR	CCL5	CXCR6	0.900131672	7.24E-208
THCA	IUPHAR	CCL5	CD247	0.918572417	6.01E-232
THCA	IUPHAR	CCL5	CD2	0.919132288	9.14E-233
THCA	IUPHAR	CCL5	CD3E	0.930160917	3.29E-250
THCA	IUPHAR	CCL5	GZMA	0.95314156	3.79E-298
THCA	Kinase	CCL5	ITK	0.856726862	4.91E-166
THCA	Kinase	CCL5	LCK	0.866869721	1.87E-174
THCA	Kinase	CCL5	ZAP70	0.883654875	4.91E-190
THCA	TF	CCL5	IRF1	0.804319242	5.73E-131
THCA	TF	CCL5	BATF	0.817319454	1.35E-138
THCA	TF	CCL5	RUNX3	0.82556105	9.40E-144
THCA	TF	CCL5	EOMES	0.831333301	1.57E-147
THCA	TF	CCL5	GFI1	0.831816422	7.47E-148
THCA	TF	CCL5	ZNF831	0.833070462	1.07E-148
THCA	TF	CCL5	SP140	0.845185949	3.27E-157
THCA	TF	CCL5	TBX21	0.848162416	2.04E-159
THCA	TF	CCL5	ZNF683	0.854009427	6.86E-164
THCA	TF	CCL5	IKZF1	0.86082859	2.33E-169
THCA	TF	CCL5	SCML4	0.876989454	1.42E-183
THCA	TSG	CCL5	CPNE7	0.801324013	2.72E-129
THCA	TSG	CCL5	IRF1	0.804319242	5.73E-131
THCA	TSG	CCL5	AIM2	0.823548506	1.81E-142
THCA	TSG	CCL5	RUNX3	0.82556105	9.40E-144
THCA	TSG	CCL5	CXCL10	0.835378484	2.90E-150
THCA	TSG	CCL5	IKZF1	0.86082859	2.33E-169
THCA	TSG	CCL5	PYHIN1	0.890077521	1.20E-196
THYM	IUPHAR	CCL5	TIGIT	0.807944211	2.45E-29
THYM	IUPHAR	CCL5	CXCR6	0.840954024	8.49E-34
THYM	IUPHAR	CCL5	LAG3	0.845374671	1.80E-34
THYM	IUPHAR	CCL5	GZMK	0.849255928	4.42E-35
THYM	IUPHAR	CCL5	GZMA	0.852788367	1.19E-35
UCEC	CGC	CCL5	IL21R	0.806191451	3.06E-47
UCEC	CGC	CCL5	PRF1	0.810857263	3.48E-48
UCEC	Epifactor	CCL5	SP140	0.816965376	1.84E-49
UCEC	IUPHAR	CCL5	LAIR1	0.801300483	2.81E-46
UCEC	IUPHAR	CCL5	CD27	0.804421209	6.88E-47
UCEC	IUPHAR	CCL5	IL21R	0.806191451	3.06E-47
UCEC	IUPHAR	CCL5	HAVCR2	0.80996994	5.29E-48
UCEC	IUPHAR	CCL5	GPR65	0.810112652	4.95E-48
UCEC	IUPHAR	CCL5	PRF1	0.810857263	3.48E-48
UCEC	IUPHAR	CCL5	CD6	0.812565686	1.55E-48
UCEC	IUPHAR	CCL5	CD37	0.813255395	1.11E-48
UCEC	IUPHAR	CCL5	GZMK	0.814612507	5.79E-49
UCEC	IUPHAR	CCL5	TIGIT	0.815243069	4.27E-49
UCEC	IUPHAR	CCL5	LAG3	0.815829168	3.21E-49
UCEC	IUPHAR	CCL5	SP140	0.816965376	1.84E-49
UCEC	IUPHAR	CCL5	S1PR4	0.817331887	1.54E-49
UCEC	IUPHAR	CCL5	IL10RA	0.833522585	3.56E-53
UCEC	IUPHAR	CCL5	SLAMF7	0.839860113	1.05E-54
UCEC	IUPHAR	CCL5	CXCR6	0.858247341	1.48E-59
UCEC	IUPHAR	CCL5	GZMA	0.859942574	4.89E-60
UCEC	IUPHAR	CCL5	ITGAL	0.876975964	2.96E-65
UCEC	IUPHAR	CCL5	CCR5	0.879546653	4.14E-66
UCEC	IUPHAR	CCL5	CD247	0.882629601	3.68E-67
UCEC	IUPHAR	CCL5	IL2RG	0.900731633	5.40E-74
UCEC	IUPHAR	CCL5	CD3E	0.901054116	3.97E-74
UCEC	IUPHAR	CCL5	CXCR3	0.906573721	1.74E-76
UCEC	IUPHAR	CCL5	CD2	0.925693607	5.87E-86
UCEC	TF	CCL5	SP140	0.816965376	1.84E-49
UCEC	TF	CCL5	TBX21	0.845043769	5.22E-56
UCEC	TF	CCL5	ZNF683	0.848363868	7.21E-57
UCEC	TSG	CCL5	DOK2	0.854345132	1.80E-58
UCS	IUPHAR	CCL5	TIGIT	0.807944211	2.45E-29
UCS	IUPHAR	CCL5	CXCR6	0.840954024	8.49E-34
UCS	IUPHAR	CCL5	LAG3	0.845374671	1.80E-34
UCS	IUPHAR	CCL5	GZMK	0.849255928	4.42E-35
UCS	IUPHAR	CCL5	GZMA	0.852788367	1.19E-35
UVM	Cell metabolism gene	CCL5	IDO1	0.810235622	8.81E-20
UVM	Cell metabolism gene	CCL5	TBXAS1	0.813635734	4.67E-20
UVM	Cell metabolism gene	CCL5	TYMP	0.842771964	1.11E-22
UVM	Cell metabolism gene	CCL5	PSMB9	0.871231253	8.10E-26
UVM	CGC	CCL5	RHOH	0.803676743	2.90E-19
UVM	CGC	CCL5	P2RY8	0.804465157	2.52E-19
UVM	CGC	CCL5	BCL11B	0.814169327	4.22E-20
UVM	CGC	CCL5	CIITA	0.830793836	1.53E-21
UVM	CGC	CCL5	VAV1	0.83139458	1.35E-21
UVM	CGC	CCL5	ITK	0.845547351	5.85E-23
UVM	CGC	CCL5	PTPN6	0.876382093	1.82E-26
UVM	CGC	CCL5	IL21R	0.878849549	8.72E-27
UVM	CGC	CCL5	IKZF1	0.884936856	1.32E-27
UVM	CGC	CCL5	CD74	0.889635293	2.84E-28
UVM	CGC	CCL5	LCP1	0.892853491	9.53E-29
UVM	CGC	CCL5	WAS	0.893766852	6.95E-29
UVM	CGC	CCL5	PRF1	0.907927563	3.45E-31
UVM	CGC	CCL5	LCK	0.912874966	4.41E-32
UVM	Epifactor	CCL5	IKZF1	0.884936856	1.32E-27
UVM	IUPHAR	CCL5	P2RY8	0.804465157	2.52E-19
UVM	IUPHAR	CCL5	AIM2	0.809955984	9.28E-20
UVM	IUPHAR	CCL5	IDO1	0.810235622	8.81E-20
UVM	IUPHAR	CCL5	GPR55	0.811928799	6.43E-20
UVM	IUPHAR	CCL5	TBXAS1	0.813635734	4.67E-20
UVM	IUPHAR	CCL5	LAIR1	0.814356997	4.07E-20
UVM	IUPHAR	CCL5	FPR3	0.816378361	2.77E-20
UVM	IUPHAR	CCL5	IL10RA	0.817804647	2.10E-20
UVM	IUPHAR	CCL5	TAP1	0.823632283	6.65E-21
UVM	IUPHAR	CCL5	CD300A	0.828800139	2.32E-21
UVM	IUPHAR	CCL5	CIITA	0.830793836	1.53E-21
UVM	IUPHAR	CCL5	UCP2	0.831092526	1.43E-21
UVM	IUPHAR	CCL5	FCER1G	0.836253675	4.74E-22
UVM	IUPHAR	CCL5	ITGB2	0.836685018	4.32E-22
UVM	IUPHAR	CCL5	HAVCR2	0.837956068	3.26E-22
UVM	IUPHAR	CCL5	ITK	0.845547351	5.85E-23
UVM	IUPHAR	CCL5	CXCR6	0.850139662	1.98E-23
UVM	IUPHAR	CCL5	IL12RB1	0.855144507	5.80E-24
UVM	IUPHAR	CCL5	P2RY6	0.859595693	1.88E-24
UVM	IUPHAR	CCL5	CD52	0.870723236	9.34E-26
UVM	IUPHAR	CCL5	PSMB9	0.871231253	8.10E-26
UVM	IUPHAR	CCL5	S1PR4	0.873516925	4.21E-26
UVM	IUPHAR	CCL5	ZAP70	0.876478487	1.77E-26
UVM	IUPHAR	CCL5	TNFRSF1B	0.878728199	9.04E-27
UVM	IUPHAR	CCL5	IL21R	0.878849549	8.72E-27
UVM	IUPHAR	CCL5	IL2RB	0.88029672	5.61E-27
UVM	IUPHAR	CCL5	PDCD1	0.883761734	1.91E-27
UVM	IUPHAR	CCL5	TIGIT	0.885853616	9.81E-28
UVM	IUPHAR	CCL5	CCR5	0.886237243	8.66E-28
UVM	IUPHAR	CCL5	CD27	0.886379568	8.27E-28
UVM	IUPHAR	CCL5	CD74	0.889635293	2.84E-28
UVM	IUPHAR	CCL5	LAG3	0.892928963	9.28E-29
UVM	IUPHAR	CCL5	GZMA	0.894717611	4.98E-29
UVM	IUPHAR	CCL5	GZMK	0.89993426	7.60E-30
UVM	IUPHAR	CCL5	CD247	0.900870937	5.37E-30
UVM	IUPHAR	CCL5	PRF1	0.907927563	3.45E-31
UVM	IUPHAR	CCL5	CD2	0.910195666	1.36E-31
UVM	IUPHAR	CCL5	LCK	0.912874966	4.41E-32
UVM	IUPHAR	CCL5	ITGAL	0.922518907	5.47E-34
UVM	IUPHAR	CCL5	CXCR3	0.936047311	3.99E-37
UVM	IUPHAR	CCL5	IL2RG	0.937009761	2.25E-37
UVM	IUPHAR	CCL5	CD3E	0.939881083	3.85E-38
UVM	Kinase	CCL5	ITK	0.845547351	5.85E-23
UVM	Kinase	CCL5	ZAP70	0.876478487	1.77E-26
UVM	Kinase	CCL5	LCK	0.912874966	4.41E-32
UVM	TF	CCL5	BCL11B	0.814169327	4.22E-20
UVM	TF	CCL5	ZNF831	0.828011094	2.73E-21
UVM	TF	CCL5	TBX21	0.828635796	2.40E-21
UVM	TF	CCL5	IRF8	0.82993668	1.83E-21
UVM	TF	CCL5	SPI1	0.836597098	4.40E-22
UVM	TF	CCL5	IRF1	0.850973819	1.62E-23
UVM	TF	CCL5	IKZF1	0.884936856	1.32E-27
UVM	TF	CCL5	BATF	0.912910005	4.34E-32
UVM	TSG	CCL5	CXCL10	0.809262605	1.05E-19
UVM	TSG	CCL5	AIM2	0.809955984	9.28E-20
UVM	TSG	CCL5	RARRES3	0.824036026	6.14E-21
UVM	TSG	CCL5	LAT2	0.825217025	4.83E-21
UVM	TSG	CCL5	GBP1	0.826369358	3.82E-21
UVM	TSG	CCL5	IRF8	0.82993668	1.83E-21
UVM	TSG	CCL5	SPI1	0.836597098	4.40E-22
UVM	TSG	CCL5	IRF1	0.850973819	1.62E-23
UVM	TSG	CCL5	RASSF5	0.860696869	1.41E-24
UVM	TSG	CCL5	DOK2	0.865562866	3.88E-25
UVM	TSG	CCL5	PTPN6	0.876382093	1.82E-26
UVM	TSG	CCL5	AIF1	0.877841171	1.18E-26
UVM	TSG	CCL5	TNFAIP8L2	0.883201837	2.28E-27
UVM	TSG	CCL5	IKZF1	0.884936856	1.32E-27

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
THCA	CCL5	CCR1	-1.45292123581675	0.000153517118172136
KIRC	CCL5	CCR3	-1.92043126224052	0.000175837898597499
BRCA	CCL5	CCR3	-11.6287089884828	0.000824317419609174
BRCA	CCL5	CCR5	1.77963575207894	0.00109837276059838
LIHC	CCL5	TNF	1.16984272940281	0.00126327311470459
LIHC	CCL5	IL6	1.64627153632596	0.00182077236082954
LUAD	CCL5	TNF	-2.02011959393159	0.00259726426174564
LIHC	CCL5	CCR5	1.93788004327333	0.00559718505377969
COAD	CCL5	IL1B	1.70197839037684	0.00938254594802858
LUSC	CCL5	IL10	-1.45553017786508	0.01064107909388
KICH	CCL5	TNF	1.12078167946604	0.0124664902687073
LUSC	CCL5	CCR3	-1.32626657204496	0.0135147608121283
THCA	CCL5	TNF	1.3339466685595	0.0190962589608376
ESCA	CCL5	IL1B	3.66012222004564	0.0419921875
LUSC	CCL5	TNF	-1.0646802690009	0.043385243245119
UCEC	CCL5	CCR2	3.08796157207097	0.046875
KICH	CCL5	CCR2	2.28741343083278	0.0482624173164368
BRCA	CCL5	TNF	-1.27744044781851	0.0492641947075503
LUSC	CCL5	CSF2	-1.63361506209922	1.06684807370829e-06
KIRC	CCL5	CCR2	2.61854404056411	1.86484053395e-10
LUSC	CCL5	CCR1	-2.46289921134003	2.7232742434021e-09
LIHC	CCL5	IL1B	3.21289899188484	2.84633422781438e-08
LUSC	CCL5	CCR5	-1.96406075403609	4.4621975457841e-05
LUAD	CCL5	IL1B	-1.5688017376538	4.80875419059834e-05
LUAD	CCL5	PF4	-3.42380224485205	5.33426993847795e-09
BLCA	CCL5	IL6	-2.3507065776799	5.340576171875e-05
BRCA	CCL5	PF4	1.18937411624998	6.9664890257017e-10
LUSC	CCL5	CCR2	-2.04872284613108	7.11803396854217e-09
LUSC	CCL5	IL6	-1.11486997433576	9.06567845421014e-06

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with CCL5

SDC1, SDC4, CCR5, Igfbp7, CXCL8, ACKR2, CCR3, CCR4, CCL2, CCR1, VCAN, TRIP6, SLC2A5, RANGAP1, RELA, EDC4, APC, BAG4, BCAR3, FZR1, CHEK2, KRAS, PALB2, PHB, PTPN1, TGFB1, WT1, C4A, NTMT1, SPATA20, AK4, UBAC1, SPRYD4, GPD1L, S100A13, CCL13, CCL16, CCL17, CCL20, CCL21, CCL24, CCL26, CCL27, CCL28, CCL11, CCL25, CXCL12, CXCL17, PF4, CXCL6, XCL1, XCL2, CXCL10, CXCL11, CXCL14, CXCL2, PPBP, CXCL9,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
CCL5	UCEC	chr17	34205610	34205610	T	C	Missense_Mutation	p.Y37C	2
CCL5	UCEC	chr17	34207261	34207261	G	T	Missense_Mutation	p.L17I	2
CCL5	ESCA	chr17	34199418	34199418	C	T	Nonsense_Mutation	p.W80*	2
CCL5	STAD	chr17	34205615	34205615	A	G	Silent		2
CCL5	STAD	chr17	34205615	34205615	A	G	Silent	p.F35F	2
CCL5	STAD	chr17	34199417	34199417	C	G	Missense_Mutation	p.W80C	2
CCL5	STAD	chr17	34199387	34199387	C	A	Missense_Mutation	p.M90I	1
CCL5	LGG	chr17	34199458	34199458	G	A	Missense_Mutation		1
CCL5	STAD	chr17	34207248	34207248	G	A	Missense_Mutation	p.A21V	1
CCL5	LIHC	chr17	34205643	34205643	T	C	Missense_Mutation	p.Y26C	1
CCL5	TGCT	chr17	34207264	34207264	C	T	Missense_Mutation		1
CCL5	LIHC	chr17	34207307	34207307	C	-	Translation_Start_Site		1
CCL5	BLCA	chr17	34199431	34199431	G	T	Missense_Mutation		1
CCL5	MESO	chr17	34199412	34199412	C	A	Missense_Mutation	p.R82L	1
CCL5	BLCA	chr17	34199431	34199431	G	T	Missense_Mutation	p.P76T	1
CCL5	SKCM	chr17	34199381	34199381	C	T	Silent	p.X92X	1
CCL5	COAD	chr17	34205639	34205639	G	T	Silent	p.S27S	1
CCL5	SKCM	chr17	34199381	34199381	C	T	Silent	p.92	1
CCL5	ESCA	chr17	34199418	34199418	C	T	Nonsense_Mutation	p.W80X	1
CCL5	STAD	chr17	34199387	34199387	C	A	Missense_Mutation		1
CCL5	ESCA	chr17	34199418	34199418	C	T	Missense_Mutation		1
CCL5	GBM	chr17	34199298	34199298	G	A	Silent		1
CCL5	LGG	chr17	34199458	34199458	G	A	Nonsense_Mutation	p.R67*	1

Copy number variation (CNV) of CCL5
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across CCL5
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
95806	SARC	TCGA-IE-A3OV	ACACA	chr17	35478276	-	CCL5	chr17	34199468	-
95806	SARC	TCGA-IE-A3OV-01A	ACACA	chr17	35478277	-	CCL5	chr17	34199468	-
91619	N/A	AG266142	CCL5	chr17	34206530	-	ZAP70	chr2	98351769	+
95819	N/A	DL054536	UBA2	chr19	34949372	+	CCL5	chr17	34199311	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
SARC	CCL5	0.00380000590068521	0.11
BRCA	CCL5	0.0047945555250083	0.13
HNSC	CCL5	0.0106715867200375	0.28
LUSC	CCL5	0.0124852556586029	0.31
STAD	CCL5	0.0138490582427249	0.33
SKCM	CCL5	0.0283756157049177	0.65
PCPG	CCL5	0.0369783801979574	0.81

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUAD	CCL5	0.036657578661378	1
THCA	CCL5	0.00992105065440491	0.31
LGG	CCL5	0.00843018739518879	0.27
BRCA	CCL5	0.00345300440048376	0.11

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
P13501	DB02322	Heparin Disaccharide I-S		Small molecule	Experimental
P13501	DB02353	Heparin Disaccharide Iii-S		Small molecule	Experimental
P13501	DB02322	Heparin Disaccharide I-S
P13501	DB02353	Heparin Disaccharide Iii-S

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0004096	Asthma	1	CTD_human
C0008312	Primary biliary cirrhosis	1	CTD_human
C0011615	Dermatitis, Atopic	1	CTD_human
C0017658	Glomerulonephritis	1	CTD_human
C0019187	Hepatitis, Alcoholic	1	CTD_human
C0020500	Hyperoxaluria	1	CTD_human
C0023892	Biliary cirrhosis	1	CTD_human
C0023893	Liver Cirrhosis, Experimental	1	CTD_human
C0034069	Pulmonary Fibrosis	1	CTD_human
C0086196	Eczema, Infantile	1	CTD_human
C0238065	Secondary Biliary Cholangitis	1	CTD_human
C0241910	Autoimmune Chronic Hepatitis	1	CTD_human
C0345967	Malignant mesothelioma	1	CTD_human
C0524610	Chronic Alcoholic Hepatitis	1	CTD_human
C1298681	Oxalosis	1	CTD_human
C1704377	Bright Disease	1	CTD_human
C4551595	Biliary Cirrhosis, Primary, 1	1	CTD_human
C4721507	Alveolitis, Fibrosing	1	CTD_human