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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MRPS14 (NCBI Gene ID:63931)

Gene Summary

Gene Summary

Gene Information	Gene Name: MRPS14
	Gene ID: 63931
	Gene Symbol	MRPS14
	Gene ID	63931
	Gene Name	mitochondrial ribosomal protein S14
	Synonyms	COXPD38\|DJ262D12.2\|HSMRPS14\|MRP-S14\|S14mt
	Cytomap	1q25.1
	Type of Gene	protein-coding
	Description	28S ribosomal protein S14, mitochondrialmitochondrial 28S ribosomal protein S14mitochondrial small ribosomal subunit protein uS14m
	Modification date	20200313
	UniProtAcc	O60783

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0032543	Mitochondrial translation
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'MRPS14[title] AND translation [title] AND human.'

Gene	Title	PMID
MRPS14	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000476371	174987553	174987712	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000476371	174987553	174987712	2132	63	221	128	15	68

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
O60783	15	68	1	128	Chain	ID=PRO_0000131013;Note=28S ribosomal protein S14%2C mitochondrial

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUAD	MRPS14	-3.02634914022647	4.24616078981701e-06
LUSC	MRPS14	-3.86726163364221	6.1453992201761e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
ACC	MRPS14	hsa-miR-27b-3p	94	-0.325925024342746	0.00352116691863917

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
UCEC	MRPS14	0.265335099	0.001743425
MESO	MRPS14	0.135558887	0.008866463
ESCA	MRPS14	0.081380171	0.027295092

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MRPS14 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	MRPS14	PMVK	0.820222156	9.81E-13
DLBC	Cell metabolism gene	MRPS14	PSMB4	0.857229308	7.46E-15
DLBC	Cell metabolism gene	MRPS14	FDPS	0.866142876	1.87E-15
DLBC	Cell metabolism gene	MRPS14	MTX1	0.866912865	1.65E-15
DLBC	Cell metabolism gene	MRPS14	SNRPE	0.868416476	1.29E-15
DLBC	Cell metabolism gene	MRPS14	PSMD4	0.873537439	5.50E-16
DLBC	Epifactor	MRPS14	VPS72	0.864274716	2.52E-15
DLBC	IUPHAR	MRPS14	PMVK	0.820222156	9.81E-13
DLBC	IUPHAR	MRPS14	FDPS	0.866142876	1.87E-15
GBM	Cell metabolism gene	MRPS14	ADH5	0.809271647	3.98E-41
GBM	Cell metabolism gene	MRPS14	LYPLA1	0.810677257	2.26E-41
GBM	Cell metabolism gene	MRPS14	SDHC	0.838962418	8.69E-47
GBM	CGC	MRPS14	SDHC	0.838962418	8.69E-47
KICH	Cell metabolism gene	MRPS14	FPGT	0.839357188	2.75E-25
KICH	Cell metabolism gene	MRPS14	BPNT1	0.85559735	3.47E-27
KICH	CGC	MRPS14	SPOP	0.811603709	1.73E-22
KICH	Epifactor	MRPS14	NSL1	0.803394977	9.54E-22
KICH	Epifactor	MRPS14	TADA1	0.807722087	3.92E-22
KICH	Epifactor	MRPS14	SPOP	0.811603709	1.73E-22
KICH	Epifactor	MRPS14	UCHL5	0.821027218	2.20E-23
KICH	IUPHAR	MRPS14	KATNA1	0.80277401	1.08E-21
KICH	Kinase	MRPS14	SCYL3	0.817421799	4.91E-23
KICH	TSG	MRPS14	IFT88	0.804055515	8.34E-22
KICH	TSG	MRPS14	SPOP	0.811603709	1.73E-22
KICH	TSG	MRPS14	APITD1	0.819023019	3.45E-23
LUSC	Cell metabolism gene	MRPS14	PIGC	0.812534283	2.94E-131
THYM	Cell metabolism gene	MRPS14	TIMM17A	0.822606206	3.33E-31
THYM	Cell metabolism gene	MRPS14	ATP5B	0.841848345	6.23E-34
THYM	Cell metabolism gene	MRPS14	MDH2	0.848129495	6.67E-35
UCS	Cell metabolism gene	MRPS14	TIMM17A	0.822606206	3.33E-31
UCS	Cell metabolism gene	MRPS14	ATP5B	0.841848345	6.23E-34
UCS	Cell metabolism gene	MRPS14	MDH2	0.848129495	6.67E-35

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
COAD	MRPS14	MRPS12	2.11566333114824	0.000125885009765625
BRCA	MRPS14	MRPS15	-2.19567551682318	0.000188684660674703
KICH	MRPS14	MRPS5	1.25108287838437	0.000249803066253662
STAD	MRPS14	MRPS16	-1.64208084987431	0.00239070039242506
LIHC	MRPS14	MRPS18C	-1.25336042046698	0.00251545393492315
COAD	MRPS14	MRPS18C	-3.48505830240365	0.00322914123535157
KIRC	MRPS14	MRPS15	1.11572283836012	0.00361818577801855
ESCA	MRPS14	MRPS12	-1.86248549814506	0.0048828125
PRAD	MRPS14	MRPS9	1.04379115553269	0.00496210155254694
HNSC	MRPS14	MRPS16	-2.01564621821803	0.00518989327406416
CHOL	MRPS14	MRPS6	2.57097392409939	0.0078125
KICH	MRPS14	MRPS2	1.26543989555015	0.0114533305168152
LUSC	MRPS14	MRPS6	-1.26158810839259	0.013873001943322
THCA	MRPS14	MRPS15	-1.19960602422995	0.0140154883942907
ESCA	MRPS14	MRPS5	-2.15440118747854	0.0185546875
ESCA	MRPS14	MRPS2	-3.20556788084675	0.0244140625
HNSC	MRPS14	MRPS12	1.33677139927136	0.0248336488591576
THCA	MRPS14	MRPS11	-3.10694728540962	0.0252226935182201
BLCA	MRPS14	MRPS11	-2.30276998968219	0.040130615234375
LUAD	MRPS14	MRPS12	-5.3399185683719	1.00823612619819e-08
THCA	MRPS14	MRPS10	1.33413691764991	1.55171507174296e-05
BRCA	MRPS14	MRPS12	-1.59537235222597	1.66215672512325e-20
LUAD	MRPS14	MRPS5	-2.20881945885927	1.77904381378076e-06
LUSC	MRPS14	MRPS9	-3.60637641031661	1.82498668910368e-07
LUSC	MRPS14	MRPS2	-2.70930846488508	1.92864354932136e-09
LUAD	MRPS14	MRPS9	-1.32894454884901	1.98978698949574e-05
BRCA	MRPS14	MRPS11	-1.24304977976804	2.31302509538916e-07
LIHC	MRPS14	MRPS12	2.67189430810317	2.56696988045444e-05
KICH	MRPS14	MRPS12	1.48941080926405	3.19480895996094e-05
PRAD	MRPS14	MRPS6	1.00673230965164	3.48152859299693e-07
LIHC	MRPS14	MRPS2	-1.14771055358828	4.2584580238307e-05
LUSC	MRPS14	MRPS5	-7.65956389962319	4.27210217182982e-06
KIRC	MRPS14	MRPS6	-3.12621933743663	4.95376546353503e-10
LUSC	MRPS14	MRPS11	-2.9004097541444	5.43966600483641e-07
KICH	MRPS14	MRPS6	-1.34376231922276	7.49826431274414e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MRPS14

DDX56, USP42, ICT1, MRPL14, MRPS11, MRPL23, MRPS10, ILF3, TUFM, FLOT2, RPS15A, COX15, RPL23, SLC25A10, MPV17, CEP250, TP53, TUBGCP3, TUBGCP4, NOL12, TRA2A, RPL6, MRPS2, ZC3H3, RPS8, TRMT10B, MRPS31, RPS2, HNRNPU, RAB5C, Gtf3c4, ERBB3, CDC14B, MRPS34, MRPS27, MRPS15, SNRNP70, RBM42, ZFC3H1, ZNF274, DLST, BRD1, ATP1A1, C6orf203, COX16, CTNNBL1, EMC7, LEO1, MINOS1-NBL1, MRPL10, MRPS28, MRPS5, MRPS9, NCAPD2, TAZ, FBXO7, EFTUD2, BPLF1, MEPCE, LARP7, RECQL4, CDK9, MRM1, SCO1, HSPD1, PDK1, TRMT61B, AURKAIP1, RC3H2, FBXW8, OBSL1, CUL9, PLEKHA4, AXL, FGFR1, GRB7, MTA2, PTPRR, SRC, ESR1, GRSF1, ZC3HAV1, ELAVL1, IGF2BP2, MEX3B, XRN2, MCF2L2, DOCK6, OCRL, ACAD9, AUH, C12orf65, C17orf80, C1QBP, C21orf33, C8orf82, MCUR1, CCDC90B, CHCHD1, CRYZ, CS, DDX28, DHX30, FASTKD2, FASTKD3, FASTKD5, GFM1, GFM2, HINT2, LONP1, LRPPRC, MCU, CCDC109B, MDH2, METTL15, METTL17, MRPL11, MRPS12, MRPS26, MRRF, MTERF3, MTFMT, MTG2, MTIF2, MTIF3, MTRF1, MTRF1L, NGRN, OTC, PMPCA, PMPCB, RMND1, RPUSD3, RPUSD4, SLC25A12, SLIRP, SSBP1, SURF1, TACO1, TBRG4, TEFM, TFAM, TMEM70, TRUB2, TSFM, VWA8, EXD2, MKI67, RBM39, NR3C1, DNAJA3, DNAJC15, DNAJC19, HSCB, MRPS23, AMOTL1, REPIN1, MRPS7, REXO4, MRPS35, MRPS24, MRPS16, MRPS17, DAP3, AARS2, COX8A, PDHA1, MAP4K3, TATDN3, UBAC1, MRPS18C, RNF123, MRPS25, MRPS18B, MRPL18, HIST1H4I, MRPS6, RBMS2, RPL35, RPL3, SRSF1, LIN28A, PRR3, APOBEC3D, CBX6, RPL10, SRP14, H1FNT, FGF17, RPL13, RPL13A, ABT1, RPL23A, SRSF7, RPL19, RPL31, RPL17, FBXW7, KLF12, KLF15, KLF4, TLX1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
MRPS14	chr1	174983841	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
MRPS14	chr1	174983870	G	A	single_nucleotide_variant	Pathogenic	Combined_oxidative_phosphorylation_deficiency_38	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MRPS14	BRCA	chr1	174983888	174983888	G	A	Missense_Mutation	p.R102W	3
MRPS14	ESCA	chr1	174983880	174983880	C	A	Missense_Mutation	p.W104C	3
MRPS14	UCEC	chr1	174983923	174983923	C	T	Missense_Mutation	p.R90Q	2
MRPS14	CESC	chr1	174987559	174987559	G	A	Missense_Mutation		2
MRPS14	UCEC	chr1	174987681	174987681	C	T	Missense_Mutation	p.R26Q	2
MRPS14	STAD	chr1	174987569	174987569	C	A	Missense_Mutation		2
MRPS14	STAD	chr1	174987569	174987569	C	A	Missense_Mutation	p.L63F	2
MRPS14	LUAD	chr1	174983875	174983875	A	G	Missense_Mutation	p.L106P	2
MRPS14	STAD	chr1	174987651	174987651	C	T	Missense_Mutation	p.R36H	2
MRPS14	ESCA	chr1	174983880	174983880	C	A	Missense_Mutation		2
MRPS14	UCEC	chr1	174983858	174983858	G	A	Missense_Mutation	p.R112C	2
MRPS14	KIRP	chr1	174987712	174987712	T	C	Missense_Mutation	p.M16V	2
MRPS14	UCEC	chr1	174983899	174983899	C	T	Missense_Mutation	p.R98H	2
MRPS14	KIRP	chr1	174987712	174987712	T	C	Splice_Site	p.M16_splice	2
MRPS14	SARC	chr1	174992537	174992537	G	T	Missense_Mutation		1
MRPS14	KIRP	chr1	174987712	174987712	T	C	Missense_Mutation		1
MRPS14	SKCM	chr1	174983953	174983953	C	T	Missense_Mutation	p.R80Q	1
MRPS14	LIHC	chr1	174983827	174983827	C	A	Missense_Mutation		1
MRPS14	SKCM	chr1	174987584	174987584	C	T	Silent	p.R58R	1
MRPS14	CESC	chr1	174987689	174987689	G	G	Silent		1
MRPS14	LIHC	chr1	174983957	174983957	G	A	Missense_Mutation		1
MRPS14	CESC	chr1	174987559	174987559	G	A	Missense_Mutation	p.L67F	1
MRPS14	LIHC	chr1	174987688	174987688	G	-	Frame_Shift_Del	p.Q24fs	1
MRPS14	BLCA	chr1	174983913	174983913	C	T	Missense_Mutation		1
MRPS14	BLCA	chr1	174983887	174983887	C	T	Missense_Mutation		1
MRPS14	ESCA	chr1	174987553	174987553	C	T	Splice_Site	e2+1	1
MRPS14	LUAD	chr1	174983830	174983830	G	A	Missense_Mutation	p.S121F	1
MRPS14	BLCA	chr1	174987626	174987626	G	T	Silent		1
MRPS14	STAD	chr1	174987603	174987603	A	G	Missense_Mutation	p.L52P	1
MRPS14	LUSC	chr1	174987657	174987657	A	G	Missense_Mutation	p.M34T	1
MRPS14	BLCA	chr1	174983913	174983913	C	T	Missense_Mutation	p.M93I	1
MRPS14	THYM	chr1	174992503	174992503	C	A	Missense_Mutation		1
MRPS14	ESCA	chr1	174987553	174987553	C	T	Splice_Site		1
MRPS14	LUSC	chr1	174987652	174987652	G	T	Missense_Mutation	p.R36S	1
MRPS14	BLCA	chr1	174987626	174987626	G	T	Silent	p.A44A	1
MRPS14	THYM	chr1	174992503	174992503	C	A	Missense_Mutation	p.K14N	1
MRPS14	ESCA	chr1	174987553	174987553	C	T	Splice_Site	.	1
MRPS14	PAAD	chr1	174983906	174983906	G	A	Missense_Mutation	p.R96C	1
MRPS14	BLCA	chr1	174983887	174983887	C	T	Missense_Mutation	p.R102Q	1
MRPS14	READ	chr1	174987577	174987577	T	C	Missense_Mutation	p.T61A	1
MRPS14	BLCA	chr1	174987587	174987587	G	C	Silent	p.L57L	1

Copy number variation (CNV) of MRPS14
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MRPS14
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
89935	N/A	AI674594	PLCH1	chr3	155424943	-	MRPS14	chr1	174981463	+
89935	N/A	AA164318	RP11-556I14.2	chr4	105833355	+	MRPS14	chr1	174982094	+
89937	N/A	BF475636	TDRD3	chr13	61109041	-	MRPS14	chr1	174981463	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
HNSC	MRPS14	0.00114788778252649	0.032
COAD	MRPS14	0.0122105256102617	0.33
ACC	MRPS14	0.0299053963155853	0.78

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	MRPS14	0.0135553889440037	0.41
LUSC	MRPS14	0.000932974143932154	0.03
KIRC	MRPS14	0.0292874864531711	0.82
BRCA	MRPS14	6.54221876784969e-05	0.0022
PAAD	MRPS14	0.00319375758003019	0.099
THYM	MRPS14	0.0263258804571082	0.76

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source