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Translation Factor: TENT4B (NCBI Gene ID:64282) |
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 Gene Summary |
| Gene Information | Gene Name: TENT4B | Gene ID: 64282 | Gene Symbol | TENT4B | Gene ID | 64282 |
| Gene Name | terminal nucleotidyltransferase 4B | |
| Synonyms | PAPD5|TRF4-2|TUT3 | |
| Cytomap | 16q12.1 | |
| Type of Gene | protein-coding | |
| Description | terminal nucleotidyltransferase 4BPAP associated domain containing 5PAP-associated domain-containing protein 5TUTase 3non-canonical poly(A) RNA polymerase PAPD5poly(A) RNA polymerase D5, non-canonicalterminal guanylyltransferaseterminal nucleotidyl | |
| Modification date | 20200313 | |
| UniProtAcc | Q8NDF8 | |
| Child GO biological process term(s) under GO:0006412 |
| GO ID | GO term |
| GO:0017148 | Negative regulation of translation |
| GO:0006417 | Regulation of translation |
| GO:0045727 | Positive regulation of translation |
| GO:0006412 | Translation |
| Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TENT4B | GO:0006378 | mRNA polyadenylation | 28383716 |
| Hgene | TENT4B | GO:0010587 | miRNA catabolic process | 25049417 |
| Hgene | TENT4B | GO:0043629 | ncRNA polyadenylation | 25049417 |
| Hgene | TENT4B | GO:0071050 | snoRNA polyadenylation | 22442037 |
| Inferred gene age of translation factor. |
| Gene | Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25 |
| TENT4B | >1119.25 |
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| We searched PubMed using 'TENT4B[title] AND translation [title] AND human.' |
| Gene | Title | PMID |
| TENT4B | . | . |
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| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. For more annotations, please visit our ExonSkipDB. |
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| Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ENST | Exon skip start (DNA) | Exon Skip end (DNA) | ORF |
| Exon skipping position in the amino acid sequence. |
| ENST | Exon skip start (DNA) | Exon Skip end (DNA) | Len(transcript seq) | Exon skip start (mRNA) | Exon Skip end (mRNA) | Len(amino acid seq) | Exon skip start (AA) | Exon Skip end (AA) |
| Potentially (partially) lost protein functional features of UniProt. |
| UniProtAcc | Exon skip start (AA) | Exon Skip end (AA) | Function feature start (AA) | Function feature end (AA) | Functional feature type | Functional feature desc. |
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| Gene expression level across TCGA pancancer |
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| Gene expression level across GTEx pantissue |
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| Expression level of gene isoforms across TCGA pancancer |
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| Expression level of gene isoforms across GTEx pantissue |
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| Cancer(tissue) type-specific expression level of Translation factor using z-score distriution |
| Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples) |
| Cancer type | Translation factor | FC | adj.pval |
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| Translation factor expression regulation through miRNA binding |
| Cancer type | Gene | miRNA | TargetScan binding score (Context++ score percentile) | Coefficient | Pvalue |
| Translation factor expression regulation through methylation in the promoter of Translation factor |
| Cancer type | Gene | methyl group b | methyl group a | DEG pval | avg methyl in b | avg methyl in a | avg exp in b | avg exp in a |
| Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation) |
| Cancer type | Gene | methyl group b | methyl group a | DEG pval | avg methyl in b | avg methyl in a | avg exp in b | avg exp in a |
| Translation factor expression regulation through copy number variation of Translation factor |
| Cancer type | Gene | Coefficient | Pvalue |
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| Strongly correlated genes belong to cellular important gene groups with TENT4B (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green) |
| Cancer type | Gene group | Translation factor | Correlated gene | Coefficient | Pvalue |
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| Protein 3D structure Visit iCn3D. |
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| Protein-protein interaction networks * Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P)) |
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| Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P)) |
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 * Edge colors based on TCGA cancer types. |
| * Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P)) |
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| Cancer type | Translation factor | Interacting protein coding gene | FC | adj.pval |
| THCA | TENT4B | ZCCHC7 | -1.69038973711539 | 0.000102991650070565 |
| KICH | TENT4B | EXOSC10 | 1.24998522750894 | 0.000139892101287842 |
| STAD | TENT4B | MTPAP | -6.52882003332551 | 0.000280400272458792 |
| HNSC | TENT4B | ADCY7 | 1.5323736967542 | 0.000333792391984389 |
| PRAD | TENT4B | SKIV2L2 | -1.27775550240692 | 0.000627023923094011 |
| CHOL | TENT4B | TUT1 | -3.79709296246396 | 0.00390625 |
| LUSC | TENT4B | TUT1 | -1.06977079427873 | 0.00418864341551449 |
| LUSC | TENT4B | ZCCHC7 | -3.31374483710271 | 0.00704157337736851 |
| STAD | TENT4B | EXOSC3 | -1.95167394249126 | 0.00733334058895707 |
| CHOL | TENT4B | ZCCHC7 | -2.18252393678436 | 0.0078125 |
| BLCA | TENT4B | ADCY7 | -3.69592158421103 | 0.0108261108398438 |
| CHOL | TENT4B | ADCY7 | -3.56073117372935 | 0.01171875 |
| LIHC | TENT4B | PAPD5 | -2.23949972243875 | 0.0155991992049249 |
| LUAD | TENT4B | PAPD5 | -1.21457322980696 | 0.0170956939444182 |
| KICH | TENT4B | ZCCHC7 | -1.87433507450193 | 0.0173123478889465 |
| LIHC | TENT4B | SKIV2L2 | -1.18110700879315 | 0.0175629065961987 |
| READ | TENT4B | TUT1 | -2.74832504699882 | 0.03125 |
| READ | TENT4B | ZCCHC7 | 2.62661541610375 | 0.03125 |
| KIRP | TENT4B | ZCCHC14 | 1.08701252416754 | 0.0375871751457453 |
| CHOL | TENT4B | ZCCHC11 | 2.70414463340831 | 0.0390625 |
| PRAD | TENT4B | TUT1 | 1.84422223754928 | 1.02977929185394e-06 |
| KICH | TENT4B | ADCY7 | -1.54137869723729 | 1.50799751281738e-05 |
| LUSC | TENT4B | ADCY7 | -1.24133016319142 | 2.51071930113563e-08 |
| COAD | TENT4B | TUT1 | -2.36693462096329 | 2.98023223876954e-07 |
| THCA | TENT4B | ZCCHC11 | -1.02904440345021 | 4.22574981970489e-05 |
| THCA | TENT4B | SKIV2L2 | -3.0696404754071 | 4.37037666427901e-06 |
| LUAD | TENT4B | MTPAP | -2.75643668768724 | 5.24732369463512e-07 |
| LUAD | TENT4B | TUT1 | -2.125133012661 | 5.3012005084452e-06 |
| LUAD | TENT4B | EXOSC3 | -2.13410426948851 | 5.48906105617824e-05 |
| LUAD | TENT4B | EXOSC10 | -5.48154088649683 | 6.13939009668372e-06 |
| LIHC | TENT4B | ZCCHC14 | -3.39723022916946 | 6.17267413816717e-05 |
| KIRC | TENT4B | ZCCHC7 | -1.53597477324229 | 7.33303941265255e-07 |
| THCA | TENT4B | EXOSC3 | 1.35051614908302 | 7.77019962091197e-05 |
| KIRC | TENT4B | PAPD5 | -1.00680783526147 | 9.16272553249916e-06 |
| Protein-protein interactors with this translation factor (BIOGRID-3.4.160) |
| PPI interactors with TENT4B |
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| Clinically associated variants from ClinVar. |
| Gene | Chr | Position | RefSeq | VarSeq | RefSeeq | VarType | Pathogenic | Disease | VarInfo |
| nsSNVs with sample frequency (size of circle) from TCGA 33 cancers. |
| SNVs and Indels |
| Gene | Cancer type | Chromosome | Start | End | RefSeeq | MutSeq | Mutation type | AAchange | # samples |
| Copy number variation (CNV) of TENT4B * Click on the image to open the original image in a new window. |
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| Fusion gene breakpoints (product of the structural variants (SVs)) across TENT4B * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion genes with this translation factor from FusionGDB2.0. |
| FusionGDB2 ID | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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| Kaplan-Meier plots with logrank tests of overall survival (OS) |
| Cancer type | Translation factor | Coefficent | Hazard ratio | Wald test pval | Likelihool ratio pval | Logrank test pval | # samples |
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| Differential gene expression between female and male. (Wilcoxon test, pval<0.05) |
| Cancer type | Translation factor | pval | adj.p |
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| Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05) |
| Cancer type | Translation factor | pval | adj.p |
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| Drugs targeting genes involved in this translation factor. (DrugBank Version 5.1.8 2021-05-08) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| Diseases associated with this translation factor. (DisGeNet 4.0) |
| Disease ID | Disease Name | # PubMeds | Disease source |
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