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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: CPEB1 (NCBI Gene ID:64506)

Gene Summary

Gene Summary

Gene Information	Gene Name: CPEB1
	Gene ID: 64506
	Gene Symbol	CPEB1
	Gene ID	64506
	Gene Name	cytoplasmic polyadenylation element binding protein 1
	Synonyms	CPE-BP1\|CPEB\|CPEB-1\|h-CPEB\|hCPEB-1
	Cytomap	15q25.2
	Type of Gene	protein-coding
	Description	cytoplasmic polyadenylation element-binding protein 1CPE-binding protein 1
	Modification date	20200320
	UniProtAcc	Q9BZB8

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0008135	Translation factor activity, RNA binding
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CPEB1	GO:0032869	cellular response to insulin stimulus	18752464
Hgene	CPEB1	GO:0071456	cellular response to hypoxia	18752464
Hgene	CPEB1	GO:1900365	positive regulation of mRNA polyadenylation	28383716

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
CPEB1	(733 - 1119.25]

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Translation Studies in PubMed

We searched PubMed using 'CPEB1[title] AND translation [title] AND human.'

Gene	Title	PMID
CPEB1	CPEB1 restrains proliferation of Glioblastoma cells through the regulation of p27(Kip1) mRNA translation	27142352

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KIRP	CPEB1	2.39393200480884	0.00361521635204554

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
UCEC	CPEB1	hsa-miR-130b-3p	93	0.419368609067961	0.0135543767686973

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
READ	CPEB1	-0.020380257	0.047287823
PCPG	CPEB1	0.022885972	0.048555424

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with CPEB1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
COAD	Cell metabolism gene	CPEB1	ELOVL4	0.804788182	4.59E-76
COAD	Cell metabolism gene	CPEB1	ST8SIA3	0.807201257	7.44E-77
COAD	Cell metabolism gene	CPEB1	GSTM5	0.809682998	1.12E-77
COAD	Cell metabolism gene	CPEB1	OGN	0.827408588	6.15E-84
COAD	Cell metabolism gene	CPEB1	PYGM	0.852496449	3.90E-94
COAD	Cell metabolism gene	CPEB1	KCNB1	0.854334304	5.89E-95
COAD	Cell metabolism gene	CPEB1	AOC3	0.854589394	4.52E-95
COAD	Cell metabolism gene	CPEB1	LYVE1	0.855787994	1.30E-95
COAD	Cell metabolism gene	CPEB1	PDE2A	0.872684388	7.93E-104
COAD	Cell metabolism gene	CPEB1	GNAO1	0.875740787	1.94E-105
COAD	CGC	CPEB1	DDR2	0.801798007	4.21E-75
COAD	CGC	CPEB1	ZEB1	0.805234582	3.28E-76
COAD	CGC	CPEB1	LIFR	0.820543261	1.97E-81
COAD	CGC	CPEB1	PHOX2B	0.822258444	4.77E-82
COAD	CGC	CPEB1	GRIN2A	0.8266385	1.19E-83
COAD	CGC	CPEB1	MYH11	0.844889524	7.46E-91
COAD	Epifactor	CPEB1	NAP1L2	0.835739767	3.93E-87
COAD	IUPHAR	CPEB1	ITPR1	0.801406608	5.62E-75
COAD	IUPHAR	CPEB1	DDR2	0.801798007	4.21E-75
COAD	IUPHAR	CPEB1	RGMA	0.807279843	7.01E-77
COAD	IUPHAR	CPEB1	GRIK5	0.807587654	5.55E-77
COAD	IUPHAR	CPEB1	ATP1B2	0.809192993	1.63E-77
COAD	IUPHAR	CPEB1	ADCYAP1R1	0.809795028	1.02E-77
COAD	IUPHAR	CPEB1	SCN9A	0.810573148	5.62E-78
COAD	IUPHAR	CPEB1	MAPK10	0.810771889	4.82E-78
COAD	IUPHAR	CPEB1	CHRNA3	0.812747632	1.03E-78
COAD	IUPHAR	CPEB1	ATP2B4	0.813203608	7.21E-79
COAD	IUPHAR	CPEB1	ADAM33	0.817257196	2.86E-80
COAD	IUPHAR	CPEB1	FXYD1	0.819634609	4.15E-81
COAD	IUPHAR	CPEB1	LIFR	0.820543261	1.97E-81
COAD	IUPHAR	CPEB1	SLC7A14	0.822605704	3.58E-82
COAD	IUPHAR	CPEB1	SCN11A	0.82297476	2.63E-82
COAD	IUPHAR	CPEB1	ABCA8	0.823917636	1.19E-82
COAD	IUPHAR	CPEB1	GRIN2A	0.8266385	1.19E-83
COAD	IUPHAR	CPEB1	CNR1	0.827268726	6.93E-84
COAD	IUPHAR	CPEB1	KCNK3	0.830152277	5.70E-85
COAD	IUPHAR	CPEB1	PTPRZ1	0.830838897	3.12E-85
COAD	IUPHAR	CPEB1	SLC22A17	0.830946096	2.84E-85
COAD	IUPHAR	CPEB1	PCSK2	0.831953664	1.17E-85
COAD	IUPHAR	CPEB1	SLC9A9	0.833151304	4.03E-86
COAD	IUPHAR	CPEB1	BCHE	0.838172609	4.24E-88
COAD	IUPHAR	CPEB1	ABCA6	0.838178136	4.22E-88
COAD	IUPHAR	CPEB1	AGTR1	0.840722824	3.95E-89
COAD	IUPHAR	CPEB1	MRGPRF	0.840746513	3.87E-89
COAD	IUPHAR	CPEB1	ATP1A2	0.853909894	9.13E-95
COAD	IUPHAR	CPEB1	PGR	0.854238224	6.50E-95
COAD	IUPHAR	CPEB1	KCNB1	0.854334304	5.89E-95
COAD	IUPHAR	CPEB1	AOC3	0.854589394	4.52E-95
COAD	IUPHAR	CPEB1	MYLK	0.866731189	8.34E-101
COAD	IUPHAR	CPEB1	PDE2A	0.872684388	7.93E-104
COAD	IUPHAR	CPEB1	DCLK1	0.874230911	1.23E-104
COAD	Kinase	CPEB1	DDR2	0.801798007	4.21E-75
COAD	Kinase	CPEB1	MAPK10	0.810771889	4.82E-78
COAD	Kinase	CPEB1	MYLK	0.866731189	8.34E-101
COAD	Kinase	CPEB1	DCLK1	0.874230911	1.23E-104
COAD	TF	CPEB1	BNC2	0.801501393	5.24E-75
COAD	TF	CPEB1	ZEB1	0.805234582	3.28E-76
COAD	TF	CPEB1	ZNF667	0.805268515	3.20E-76
COAD	TF	CPEB1	ZNF835	0.817179216	3.05E-80
COAD	TF	CPEB1	MEIS1	0.817561949	2.24E-80
COAD	TF	CPEB1	PHOX2B	0.822258444	4.77E-82
COAD	TF	CPEB1	SALL2	0.823464651	1.74E-82
COAD	TF	CPEB1	HAND2	0.844991173	6.77E-91
COAD	TF	CPEB1	PKNOX2	0.847692978	4.83E-92
COAD	TF	CPEB1	SOX10	0.853523148	1.36E-94
COAD	TF	CPEB1	PGR	0.854238224	6.50E-95
COAD	TF	CPEB1	PEG3	0.869711924	2.67E-102
COAD	TSG	CPEB1	DDR2	0.801798007	4.21E-75
COAD	TSG	CPEB1	CMTM5	0.804675192	4.99E-76
COAD	TSG	CPEB1	MAPK10	0.810771889	4.82E-78
COAD	TSG	CPEB1	SRPX	0.814662515	2.28E-79
COAD	TSG	CPEB1	SYNM	0.81508092	1.63E-79
COAD	TSG	CPEB1	LIFR	0.820543261	1.97E-81
COAD	TSG	CPEB1	SALL2	0.823464651	1.74E-82
COAD	TSG	CPEB1	GRIN2A	0.8266385	1.19E-83
COAD	TSG	CPEB1	TCEAL7	0.830327774	4.89E-85
COAD	TSG	CPEB1	CNN1	0.830993605	2.73E-85
COAD	TSG	CPEB1	PCDH10	0.832169211	9.66E-86
COAD	TSG	CPEB1	SFRP1	0.835581824	4.54E-87
COAD	TSG	CPEB1	AGTR1	0.840722824	3.95E-89
COAD	TSG	CPEB1	SYNPO2	0.852388224	4.35E-94
COAD	TSG	CPEB1	PGR	0.854238224	6.50E-95
COAD	TSG	CPEB1	SPARCL1	0.855678134	1.45E-95
COAD	TSG	CPEB1	C2orf40	0.862402334	1.07E-98
COAD	TSG	CPEB1	CADM3	0.869702073	2.70E-102
COAD	TSG	CPEB1	PEG3	0.869711924	2.67E-102
COAD	TSG	CPEB1	FHL1	0.870085619	1.72E-102
PAAD	TF	CPEB1	SALL2	0.803425841	1.28E-42
PAAD	TSG	CPEB1	SALL2	0.803425841	1.28E-42
PRAD	Cell metabolism gene	CPEB1	ADCY5	0.80101816	3.27E-124
PRAD	IUPHAR	CPEB1	ADCY5	0.80101816	3.27E-124
PRAD	IUPHAR	CPEB1	SLC8A1	0.811943407	3.23E-130
READ	Cell metabolism gene	CPEB1	PDE1A	0.803643414	5.90E-25
READ	Cell metabolism gene	CPEB1	KCNB1	0.814702327	4.03E-26
READ	Cell metabolism gene	CPEB1	TUBB6	0.827051097	1.61E-27
READ	Cell metabolism gene	CPEB1	CAV1	0.836465267	1.16E-28
READ	Cell metabolism gene	CPEB1	PDE2A	0.842509298	1.97E-29
READ	Cell metabolism gene	CPEB1	ADCY2	0.843649689	1.40E-29
READ	Cell metabolism gene	CPEB1	PDE5A	0.846783658	5.35E-30
READ	Cell metabolism gene	CPEB1	PYGM	0.854075515	5.28E-31
READ	Cell metabolism gene	CPEB1	AOC3	0.876248045	1.96E-34
READ	Cell metabolism gene	CPEB1	GNAO1	0.878412549	8.35E-35
READ	CGC	CPEB1	FGFR1	0.805372358	3.92E-25
READ	CGC	CPEB1	FLNA	0.812958109	6.22E-26
READ	CGC	CPEB1	FNBP1	0.814701017	4.03E-26
READ	CGC	CPEB1	DDR2	0.816189566	2.77E-26
READ	CGC	CPEB1	RSPO2	0.833081989	3.05E-28
READ	CGC	CPEB1	MYH11	0.846482676	5.88E-30
READ	CGC	CPEB1	ZEB1	0.863572469	2.12E-32
READ	Epifactor	CPEB1	PRDM6	0.870979414	1.46E-33
READ	IUPHAR	CPEB1	PDE1A	0.803643414	5.90E-25
READ	IUPHAR	CPEB1	FGFR1	0.805372358	3.92E-25
READ	IUPHAR	CPEB1	KCNA1	0.80676996	2.81E-25
READ	IUPHAR	CPEB1	ADAM33	0.809457527	1.47E-25
READ	IUPHAR	CPEB1	ITPR1	0.810071713	1.27E-25
READ	IUPHAR	CPEB1	ABCA9	0.810707657	1.08E-25
READ	IUPHAR	CPEB1	EPHA6	0.814346195	4.40E-26
READ	IUPHAR	CPEB1	KCNB1	0.814702327	4.03E-26
READ	IUPHAR	CPEB1	DDR2	0.816189566	2.77E-26
READ	IUPHAR	CPEB1	KCNMA1	0.817523975	1.97E-26
READ	IUPHAR	CPEB1	GPR162	0.819248452	1.27E-26
READ	IUPHAR	CPEB1	MAPK10	0.8255362	2.43E-27
READ	IUPHAR	CPEB1	CNGA3	0.827596076	1.39E-27
READ	IUPHAR	CPEB1	ATP2B4	0.829240548	8.89E-28
READ	IUPHAR	CPEB1	SLC22A17	0.829340659	8.64E-28
READ	IUPHAR	CPEB1	ATP1A2	0.840535422	3.55E-29
READ	IUPHAR	CPEB1	SLC8A1	0.841446835	2.71E-29
READ	IUPHAR	CPEB1	PDE2A	0.842509298	1.97E-29
READ	IUPHAR	CPEB1	MRGPRF	0.842975412	1.71E-29
READ	IUPHAR	CPEB1	ADCY2	0.843649689	1.40E-29
READ	IUPHAR	CPEB1	PDE5A	0.846783658	5.35E-30
READ	IUPHAR	CPEB1	PGR	0.849361065	2.39E-30
READ	IUPHAR	CPEB1	SLC9A9	0.850485867	1.68E-30
READ	IUPHAR	CPEB1	RGMA	0.862934887	2.65E-32
READ	IUPHAR	CPEB1	DCLK1	0.868960512	3.07E-33
READ	IUPHAR	CPEB1	GRIK5	0.870259195	1.90E-33
READ	IUPHAR	CPEB1	AOC3	0.876248045	1.96E-34
READ	IUPHAR	CPEB1	MYLK	0.904750749	5.76E-40
READ	Kinase	CPEB1	FGFR1	0.805372358	3.92E-25
READ	Kinase	CPEB1	EPHA6	0.814346195	4.40E-26
READ	Kinase	CPEB1	DDR2	0.816189566	2.77E-26
READ	Kinase	CPEB1	MAPK10	0.8255362	2.43E-27
READ	Kinase	CPEB1	DCLK1	0.868960512	3.07E-33
READ	Kinase	CPEB1	MYLK	0.904750749	5.76E-40
READ	TF	CPEB1	SALL2	0.804924009	4.36E-25
READ	TF	CPEB1	DZIP1	0.806208727	3.21E-25
READ	TF	CPEB1	MEF2C	0.806634879	2.90E-25
READ	TF	CPEB1	NPAS3	0.806899091	2.73E-25
READ	TF	CPEB1	GLI3	0.810530963	1.13E-25
READ	TF	CPEB1	ZNF667	0.812275011	7.37E-26
READ	TF	CPEB1	ZNF781	0.818107349	1.70E-26
READ	TF	CPEB1	HAND2	0.825251384	2.62E-27
READ	TF	CPEB1	ZNF835	0.826643344	1.80E-27
READ	TF	CPEB1	MEIS2	0.830265878	6.70E-28
READ	TF	CPEB1	BNC2	0.839021152	5.54E-29
READ	TF	CPEB1	PGR	0.849361065	2.39E-30
READ	TF	CPEB1	ZEB1	0.863572469	2.12E-32
READ	TF	CPEB1	MEIS1	0.86498686	1.29E-32
READ	TF	CPEB1	PRDM6	0.870979414	1.46E-33
READ	TF	CPEB1	PEG3	0.878229017	8.98E-35
READ	TSG	CPEB1	SALL2	0.804924009	4.36E-25
READ	TSG	CPEB1	SFRP1	0.805804197	3.54E-25
READ	TSG	CPEB1	PLEKHO1	0.809836505	1.34E-25
READ	TSG	CPEB1	RNF180	0.810645671	1.10E-25
READ	TSG	CPEB1	FLNA	0.812958109	6.22E-26
READ	TSG	CPEB1	C2orf40	0.813114964	5.99E-26
READ	TSG	CPEB1	DDR2	0.816189566	2.77E-26
READ	TSG	CPEB1	SYNM	0.824999217	2.80E-27
READ	TSG	CPEB1	MAPK10	0.8255362	2.43E-27
READ	TSG	CPEB1	CADM3	0.827620595	1.38E-27
READ	TSG	CPEB1	TNFSF12	0.829064021	9.33E-28
READ	TSG	CPEB1	CNN1	0.830137584	6.94E-28
READ	TSG	CPEB1	CAV1	0.836465267	1.16E-28
READ	TSG	CPEB1	TCEAL7	0.838236637	6.97E-29
READ	TSG	CPEB1	TAGLN	0.846539482	5.77E-30
READ	TSG	CPEB1	PGR	0.849361065	2.39E-30
READ	TSG	CPEB1	SYNPO2	0.856457087	2.41E-31
READ	TSG	CPEB1	MRVI1	0.86093978	5.30E-32
READ	TSG	CPEB1	SPARCL1	0.871730691	1.10E-33
READ	TSG	CPEB1	FHL1	0.873131255	6.49E-34
READ	TSG	CPEB1	PEG3	0.878229017	8.98E-35
STAD	Cell metabolism gene	CPEB1	PYGM	0.806946609	1.65E-104
STAD	Cell metabolism gene	CPEB1	CDO1	0.814123434	8.18E-108
STAD	Cell metabolism gene	CPEB1	KCNB1	0.827559447	2.11E-114
STAD	Cell metabolism gene	CPEB1	GNAO1	0.834352812	5.91E-118
STAD	Cell metabolism gene	CPEB1	AOC3	0.840608649	2.26E-121
STAD	IUPHAR	CPEB1	ADAM33	0.809602015	1.02E-105
STAD	IUPHAR	CPEB1	MYLK	0.814822817	3.83E-108
STAD	IUPHAR	CPEB1	MRGPRF	0.815466676	1.90E-108
STAD	IUPHAR	CPEB1	ATP1A2	0.81992869	1.36E-110
STAD	IUPHAR	CPEB1	PGR	0.821623619	2.01E-111
STAD	IUPHAR	CPEB1	KCNB1	0.827559447	2.11E-114
STAD	IUPHAR	CPEB1	AOC3	0.840608649	2.26E-121
STAD	Kinase	CPEB1	MYLK	0.814822817	3.83E-108
STAD	TF	CPEB1	ZNF135	0.800431727	1.25E-101
STAD	TF	CPEB1	PKNOX2	0.806498882	2.62E-104
STAD	TF	CPEB1	PEG3	0.815085245	2.88E-108
STAD	TF	CPEB1	PGR	0.821623619	2.01E-111
STAD	TSG	CPEB1	SPARCL1	0.810265928	5.08E-106
STAD	TSG	CPEB1	MRVI1	0.813346789	1.89E-107
STAD	TSG	CPEB1	CDO1	0.814123434	8.18E-108
STAD	TSG	CPEB1	NDN	0.81483509	3.78E-108
STAD	TSG	CPEB1	PEG3	0.815085245	2.88E-108
STAD	TSG	CPEB1	PGR	0.821623619	2.01E-111
STAD	TSG	CPEB1	FHL1	0.832875716	3.61E-117
TGCT	Cell metabolism gene	CPEB1	GIP	0.806572398	5.48E-37
TGCT	Cell metabolism gene	CPEB1	HDC	0.808061517	3.22E-37
TGCT	Cell metabolism gene	CPEB1	ELOVL6	0.822788183	1.26E-39
TGCT	Cell metabolism gene	CPEB1	MUC21	0.827720956	1.76E-40
TGCT	Cell metabolism gene	CPEB1	DGKD	0.834795274	9.30E-42
TGCT	Cell metabolism gene	CPEB1	AWAT2	0.835053387	8.34E-42
TGCT	Cell metabolism gene	CPEB1	ADAL	0.836015316	5.53E-42
TGCT	Cell metabolism gene	CPEB1	AGPAT6	0.841605243	4.80E-43
TGCT	Cell metabolism gene	CPEB1	B3GAT2	0.853855782	1.60E-45
TGCT	Cell metabolism gene	CPEB1	MTMR3	0.889998939	2.15E-54
TGCT	Cell metabolism gene	CPEB1	ELOVL3	0.893604153	1.91E-55
TGCT	CGC	CPEB1	KIT	0.830374375	5.93E-41
TGCT	CGC	CPEB1	PRDM1	0.834871229	9.01E-42
TGCT	CGC	CPEB1	TCL1A	0.851171515	5.84E-45
TGCT	CGC	CPEB1	ELL	0.881901819	3.70E-52
TGCT	Epifactor	CPEB1	ERCC6	0.801019756	3.85E-36
TGCT	Epifactor	CPEB1	TLK1	0.801383613	3.40E-36
TGCT	Epifactor	CPEB1	SFMBT1	0.808387205	2.86E-37
TGCT	Epifactor	CPEB1	MSL2	0.815662265	1.96E-38
TGCT	Epifactor	CPEB1	L3MBTL2	0.819289289	4.93E-39
TGCT	Epifactor	CPEB1	HIST1H3C	0.820606372	2.96E-39
TGCT	Epifactor	CPEB1	TDRKH	0.829037417	1.03E-40
TGCT	Epifactor	CPEB1	HDAC9	0.830558553	5.50E-41
TGCT	Epifactor	CPEB1	GATAD2A	0.834712196	9.64E-42
TGCT	Epifactor	CPEB1	PRDM1	0.834871229	9.01E-42
TGCT	Epifactor	CPEB1	BAHD1	0.882643321	2.35E-52
TGCT	Epifactor	CPEB1	BMI1	0.892444224	4.20E-55
TGCT	IUPHAR	CPEB1	KSR2	0.800513697	4.59E-36
TGCT	IUPHAR	CPEB1	TLK1	0.801383613	3.40E-36
TGCT	IUPHAR	CPEB1	HDC	0.808061517	3.22E-37
TGCT	IUPHAR	CPEB1	LANCL2	0.808458451	2.79E-37
TGCT	IUPHAR	CPEB1	ABCC12	0.80928057	2.07E-37
TGCT	IUPHAR	CPEB1	KCNK13	0.811681442	8.62E-38
TGCT	IUPHAR	CPEB1	NEK5	0.824956657	5.35E-40
TGCT	IUPHAR	CPEB1	TRPC5	0.825555311	4.21E-40
TGCT	IUPHAR	CPEB1	ACVR1B	0.827777323	1.72E-40
TGCT	IUPHAR	CPEB1	KIT	0.830374375	5.93E-41
TGCT	IUPHAR	CPEB1	HDAC9	0.830558553	5.50E-41
TGCT	IUPHAR	CPEB1	DCLK3	0.830934669	4.71E-41
TGCT	IUPHAR	CPEB1	KCNC1	0.845759769	7.34E-44
TGCT	IUPHAR	CPEB1	GABRA3	0.847323641	3.57E-44
TGCT	IUPHAR	CPEB1	NLRP14	0.857000358	3.41E-46
TGCT	IUPHAR	CPEB1	AQP6	0.857853039	2.23E-46
TGCT	IUPHAR	CPEB1	KCNA2	0.870475268	2.87E-49
TGCT	IUPHAR	CPEB1	MLNR	0.87292367	7.29E-50
TGCT	IUPHAR	CPEB1	NLRP9	0.874781148	2.53E-50
TGCT	IUPHAR	CPEB1	SLC43A1	0.881066354	6.16E-52
TGCT	IUPHAR	CPEB1	SLC12A6	0.884514762	7.33E-53
TGCT	IUPHAR	CPEB1	HCN4	0.886321591	2.34E-53
TGCT	IUPHAR	CPEB1	SLC5A7	0.89929287	3.47E-57
TGCT	Kinase	CPEB1	KSR2	0.800513697	4.59E-36
TGCT	Kinase	CPEB1	TLK1	0.801383613	3.40E-36
TGCT	Kinase	CPEB1	NEK5	0.824956657	5.35E-40
TGCT	Kinase	CPEB1	ACVR1B	0.827777323	1.72E-40
TGCT	Kinase	CPEB1	KIT	0.830374375	5.93E-41
TGCT	Kinase	CPEB1	DCLK3	0.830934669	4.71E-41
TGCT	TF	CPEB1	ZNF705D	0.806212598	6.23E-37
TGCT	TF	CPEB1	ZNF709	0.808554059	2.69E-37
TGCT	TF	CPEB1	CSRNP2	0.81206525	7.49E-38
TGCT	TF	CPEB1	ZNF470	0.813031912	5.24E-38
TGCT	TF	CPEB1	ZNF566	0.814259699	3.32E-38
TGCT	TF	CPEB1	ZNF225	0.814499316	3.03E-38
TGCT	TF	CPEB1	ZNF845	0.815424181	2.15E-38
TGCT	TF	CPEB1	ZNF530	0.818566703	6.51E-39
TGCT	TF	CPEB1	ZNF451	0.822713502	1.30E-39
TGCT	TF	CPEB1	ZNF417	0.823701078	8.81E-40
TGCT	TF	CPEB1	ZNF548	0.825786773	3.84E-40
TGCT	TF	CPEB1	ZNF570	0.828466767	1.30E-40
TGCT	TF	CPEB1	GATAD2A	0.834712196	9.64E-42
TGCT	TF	CPEB1	PRDM1	0.834871229	9.01E-42
TGCT	TF	CPEB1	ZFP30	0.837216961	3.29E-42
TGCT	TF	CPEB1	ZNF227	0.843003212	2.57E-43
TGCT	TF	CPEB1	TGIF2LX	0.845405414	8.64E-44
TGCT	TF	CPEB1	ZNF14	0.847726826	2.96E-44
TGCT	TF	CPEB1	ZNF2	0.850942674	6.52E-45
TGCT	TF	CPEB1	ZNF571	0.853484443	1.92E-45
TGCT	TF	CPEB1	ZNF610	0.853633967	1.79E-45
TGCT	TF	CPEB1	ZNF235	0.855686784	6.54E-46
TGCT	TF	CPEB1	ZBTB43	0.8743704	3.20E-50
TGCT	TF	CPEB1	ZNF654	0.874838384	2.44E-50
TGCT	TF	CPEB1	ZNF582	0.87549219	1.68E-50
TGCT	TF	CPEB1	DMRT1	0.877767511	4.44E-51
TGCT	TF	CPEB1	ZNF549	0.882792764	2.14E-52
TGCT	TF	CPEB1	ZNF526	0.887106278	1.41E-53
TGCT	TF	CPEB1	ZNF569	0.89210299	5.28E-55
TGCT	TF	CPEB1	ZNF304	0.896384073	2.77E-56
TGCT	TF	CPEB1	ZNF766	0.899091609	4.01E-57
TGCT	TF	CPEB1	BNC1	0.90882137	2.39E-60
TGCT	TSG	CPEB1	CDK2AP1	0.817278376	1.06E-38
TGCT	TSG	CPEB1	LZTS1	0.819708262	4.20E-39
TGCT	TSG	CPEB1	PIAS1	0.820628977	2.94E-39
TGCT	TSG	CPEB1	NRCAM	0.823851139	8.30E-40
TGCT	TSG	CPEB1	PRDM1	0.834871229	9.01E-42
TGCT	TSG	CPEB1	SMCHD1	0.844975521	1.05E-43
TGCT	TSG	CPEB1	CSMD1	0.86051287	5.79E-47

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
THCA	CPEB1	PARN	1.04396980067497	0.000304188719124466
COAD	CPEB1	NGDN	-4.02546446402236	0.000411599874496461
COAD	CPEB1	PARN	-2.63498150551249	0.00197160243988037
THCA	CPEB1	NGDN	-2.52701598765808	0.00504614667974473
ESCA	CPEB1	LSM14A	-3.69586672689126	0.013671875
CHOL	CPEB1	PABPC1L	2.78331172494241	0.01953125
HNSC	CPEB1	LSM14A	-1.43426729122269	0.0256568653412614
COAD	CPEB1	LSM14A	-1.67535009491501	0.0291509032249451
READ	CPEB1	AURKA	2.44185876815714	0.03125
READ	CPEB1	SYMPK	-2.3101868669209	0.03125
LUAD	CPEB1	PABPC1L	-2.51583026501524	1.30692790027182e-05
KIRP	CPEB1	AURKA	-1.39611353637217	2.00234353542328e-08
LUSC	CPEB1	PABPC1L	-2.50538171229714	3.79466966402315e-05
STAD	CPEB1	PABPC1L	-2.43245436541992	4.02145087718964e-06
KICH	CPEB1	AURKA	-5.44989541314857	5.96046447753906e-08
LIHC	CPEB1	PABPC1L	-2.77562492714404	6.17267413816717e-05
KICH	CPEB1	EIF4E	1.61675210562671	6.55651092529297e-06
KICH	CPEB1	PABPC1L	2.22531868187715	7.49826431274414e-05
KIRC	CPEB1	PARN	-1.24669594753579	7.99520634435384e-07
THCA	CPEB1	DDX6	-4.18593714762416	8.3083675979354e-06
COAD	CPEB1	AURKA	2.45048892666079	8.94069671630861e-08

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with CPEB1

CPEB1, APP, SLC16A7, PIN1, SYMPK, METAP1D, GBP5, APBA3, CSTF2T, GAN, NMD3, CSTF2, ZFP36, FASN, MESDC2, CREB1, IGF2BP3, UBAP2L, PUM1, UBAP2, PUM2, EIF4ENIF1, IGF2BP1, RBMS1, EDC4, GIGYF2, LARP4, PATL1, DCP1B, XRN1, LSM14A, TNRC6A, EDC3, LSM14B, DCP1A, CNOT8, CNOT7, AGO2, CNOT1, CCDC85C, GTPBP1, KIAA0355, PFDN1, CNOT3, ANKRD17, GIGYF1, OFD1, HSPA4, HELZ, PRRC2A, IRAK1, GNB2L1, OTUD4, YWHAH, R3HDM1, TTC31, PAN3, PRRC2B, RC3H1, CC2D1A, CEP85, USP54, ZC3HAV1, YTHDF3, ANKHD1, RNF214, SMAP2, SMG7, RQCD1, LARP4B, UPF1, FUBP3, PPP1R13B, MYCBP, ATXN2, FAM195A, KIAA1671, YTHDF1, UNK, CNOT10, AGO3, MOV10, TNRC6C, FBRSL1, CNOT2, CNOT11, AGO1, TNRC6B, SMG5, R3HDM2, KIAA0430, PRRC2C, YTHDF2, MAGED1, IGF2BP2, HNRNPR, SYNCRIP, PABPC1, YBX3, YBX1, ELAVL2, PABPC4, ELAVL1, MSI2, STAU1, STAU2, NKRF, HSPA4L, HNRNPL, RPS19, MATR3, RPS10, RPS13, RPS11, RPS15, RPS24, RPL39, PURA, LGALS3BP, CPSF1, ILF2, LARP1, FIP1L1, DHX30, SUGP2, CCAR2, HSPH1, ZFR, PURB, STRBP, DDX50, HNRNPUL1, XRN2, DHX36, ZCCHC3, ATAD3A, FAM120A,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
CPEB1	chr15	83224696	C	.	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
CPEB1	chr15	83310525	CAAAGGTTATCCATGCCTAAGTGTTCTCCTGAACTACTGAAAGTAAAGCTCAACCCCAGTCAGTCAGGAATCCTCCCAGGTCCAAGTTAATCAAAACCACATTATATATTAGGGTGGCAAAATAATCCCTAACATTGGGCTTTAAAATGACACCTAATAAAATTCATTGGAAATTACATCTACAATGTGAATTTAGCACTCTGAAATTTGGATACTAACTTTTTACAGCAAGTCAGATAATTTTCCTATGAAAAT	C	Deletion	Uncertain_significance	Primary_amenorrhea	SO:0001627\|intron_variant	SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
CPEB1	LUAD	chr15	83215961	83215961	G	A	Nonsense_Mutation	p.Q503*	6
CPEB1	BRCA	chr15	83240140	83240140	C	G	Missense_Mutation	p.W111C	4
CPEB1	BRCA	chr15	83224732	83224732	A	C	Missense_Mutation	p.S249R	3
CPEB1	UCEC	chr15	83215199	83215199	G	A	Nonsense_Mutation	p.R523*	2
CPEB1	CESC	chr15	83215935	83215935	G	A	Silent		2
CPEB1	UCEC	chr15	83215243	83215243	G	A	Missense_Mutation	p.S508F	2
CPEB1	CESC	chr15	83226522	83226522	G	C	Silent		2
CPEB1	STAD	chr15	83296089	83296089	G	A	Silent		2
CPEB1	LUAD	chr15	83222209	83222209	C	T	Missense_Mutation	p.M357I	2
CPEB1	UCEC	chr15	83215935	83215935	G	A	Silent	p.S484	2
CPEB1	CESC	chr15	83224721	83224721	C	G	Missense_Mutation		2
CPEB1	UCEC	chr15	83222235	83222235	G	A	Missense_Mutation	p.P349S	2
CPEB1	LIHC	chr15	83226572	83226572	T	A	Missense_Mutation		2
CPEB1	PRAD	chr15	83221233	83221233	C	A	Missense_Mutation	p.K426N	2
CPEB1	UCEC	chr15	83222257	83222257	C	T	Nonsense_Mutation	p.W341*	2
CPEB1	BLCA	chr15	83215251	83215251	T	C	Silent		2
CPEB1	LUAD	chr15	83226530	83226530	C	G	Missense_Mutation	p.D223H	2
CPEB1	UCEC	chr15	83222665	83222665	C	A	Missense_Mutation	p.K312N	2
CPEB1	UCEC	chr15	83226509	83226509	C	T	Splice_Site	e4+1	2
CPEB1	BRCA	chr15	83218208	83218208	A	C	Splice_Site	e9+2	2
CPEB1	UCEC	chr15	83226577	83226577	G	T	Missense_Mutation	p.S180Y	2
CPEB1	SARC	chr15	83297194	83297194	G	C	Missense_Mutation	p.A6G	2
CPEB1	BRCA	chr15	83240148	83240148	G	A	Nonsense_Mutation	p.R109*	2
CPEB1	SKCM	chr15	83221249	83221249	C	T	Missense_Mutation	p.R421Q	2
CPEB1	UCEC	chr15	83240227	83240227	C	T	Silent	p.A82	2
CPEB1	SKCM	chr15	83224840	83224840	G	A	Silent	p.F240F	2
CPEB1	UCEC	chr15	83296006	83296006	G	T	Missense_Mutation	p.S43Y	2
CPEB1	UCEC	chr15	83215190	83215190	C	T	Splice_Site	e11+1	2
CPEB1	SKCM	chr15	83218215	83218215	G	A	Missense_Mutation	p.P492L	2
CPEB1	UVM	chr15	83218265	83218265	T	C	Silent		2
CPEB1	STAD	chr15	83296089	83296089	G	A	Silent	p.C42C	1
CPEB1	BLCA	chr15	83295967	83295967	C	T	Missense_Mutation	p.R83Q	1
CPEB1	HNSC	chr15	83226688	83226688	G	A	Missense_Mutation		1
CPEB1	LIHC	chr15	83222697	83222697	G	-	Frame_Shift_Del	p.R329fs	1
CPEB1	SKCM	chr15	83222244	83222244	C	T	Missense_Mutation	p.G271S	1
CPEB1	LUAD	chr15	83226624	83226624	T	A	Silent	p.S191S	1
CPEB1	SKCM	chr15	83240213	83240213	C	G	Missense_Mutation	p.R114P	1
CPEB1	KIRC	chr15	83226709	83226709	C	A	Missense_Mutation	p.G136V	1
CPEB1	LGG	chr15	83296017	83296017	T	C	Translation_Start_Site		1
CPEB1	PAAD	chr15	83215935	83215935	G	T	Missense_Mutation	p.S484R	1
CPEB1	SKCM	chr15	83226581	83226581	G	A	Nonsense_Mutation	p.R206*	1
CPEB1	UVM	chr15	83218265	83218265	T	C	Silent	p.L448L	1
CPEB1	BLCA	chr15	83215217	83215217	G	A	Missense_Mutation		1
CPEB1	COAD	chr15	83222280	83222280	A	C	Missense_Mutation	p.F259V	1
CPEB1	STAD	chr15	83218321	83218321	C	T	Missense_Mutation	p.G495S	1
CPEB1	BLCA	chr15	83240207	83240207	A	G	Missense_Mutation	p.L116P	1
CPEB1	HNSC	chr15	83296034	83296034	G	A	Nonsense_Mutation	p.R61*	1
CPEB1	LIHC	chr15	83218257	83218257	C	-	Frame_Shift_Del	p.G478fs	1
CPEB1	SKCM	chr15	83222287	83222287	G	A	Silent	p.F256F	1
CPEB1	LUAD	chr15	83226674	83226674	G	T	Missense_Mutation	p.P175T	1
CPEB1	SKCM	chr15	83240212	83240212	A	G	Silent	p.R114R	1
CPEB1	KIRC	chr15	83215272	83215272	C	A	Splice_Site	.	1
CPEB1	COAD	chr15	83296034	83296034	G	A	Nonsense_Mutation	p.R34X	1
CPEB1	LGG	chr15	83296072	83296072	G	A	Missense_Mutation		1
CPEB1	PAAD	chr15	83215935	83215935	G	T	Missense_Mutation	p.S511R	1
CPEB1	BLCA	chr15	83222281	83222281	A	C	Silent		1
CPEB1	SKCM	chr15	83226583	83226583	G	A	Missense_Mutation	p.S103F	1
CPEB1	STAD	chr15	83240228	83240228	G	A	Missense_Mutation	p.A142V	1
CPEB1	BLCA	chr15	83222716	83222716	C	G	Missense_Mutation	p.W322C	1
CPEB1	HNSC	chr15	83226644	83226644	C	G	Missense_Mutation	p.D185H	1
CPEB1	LUAD	chr15	83221331	83221331	C	A	Missense_Mutation	p.V394F	1
CPEB1	SKCM	chr15	83240211	83240211	C	A	Missense_Mutation	p.G115C	1
CPEB1	KIRC	chr15	83221251	83221251	G	C	Missense_Mutation	p.S393R	1
CPEB1	BLCA	chr15	83295967	83295967	C	T	Missense_Mutation		1
CPEB1	ESCA	chr15	83218339	83218340	-	G	Frame_Shift_Ins	p.S428fs	1
CPEB1	LIHC	chr15	83215238	83215238	A	G	Missense_Mutation		1
CPEB1	PAAD	chr15	83215935	83215935	G	T	Missense_Mutation	p.S489R	1
CPEB1	STAD	chr15	83296089	83296089	G	A	Silent	p.C15C	1
CPEB1	LUAD	chr15	83221258	83221258	A	T	Missense_Mutation	p.M418K	1
CPEB1	SKCM	chr15	83218370	83218370	A	T	Missense_Mutation	p.F338L	1
CPEB1	STAD	chr15	83218272	83218272	T	G	Missense_Mutation	p.N511T	1
CPEB1	BLCA	chr15	83222700	83222700	G	T	Missense_Mutation	p.P328T	1
CPEB1	HNSC	chr15	83221346	83221346	C	A	Nonsense_Mutation	p.E389*	1
CPEB1	LUAD	chr15	83221240	83221240	C	A	Missense_Mutation	p.R424L	1
CPEB1	SKCM	chr15	83226583	83226583	G	A	Missense_Mutation	p.S205F	1
CPEB1	CESC	chr15	83240306	83240306	G	A	Missense_Mutation		1
CPEB1	KIRC	chr15	83226709	83226709	C	A	Missense_Mutation	p.G163V	1
CPEB1	BLCA	chr15	83240207	83240207	A	G	Missense_Mutation		1
CPEB1	ESCA	chr15	83218339	83218340	-	-	Frame_Shift_Ins		1
CPEB1	STAD	chr15	83213377	83213377	G	-	Frame_Shift_Del	p.L551fs	1
CPEB1	SKCM	chr15	83226629	83226629	G	A	Missense_Mutation	p.P88S	1
CPEB1	STAD	chr15	83221347	83221347	G	A	Silent	p.F426F	1
CPEB1	BLCA	chr15	83296112	83296112	C	G	Missense_Mutation	p.E68Q	1
CPEB1	HNSC	chr15	83215266	83215266	C	G	Missense_Mutation	p.Q527H	1
CPEB1	LUAD	chr15	83215961	83215961	G	A	Nonsense_Mutation	p.Q541*	1
CPEB1	SKCM	chr15	83221280	83221280	G	A	Silent	p.L411L	1
CPEB1	CESC	chr15	83222290	83222290	G	T	Silent		1
CPEB1	KIRC	chr15	83215272	83215272	C	A	Splice_Site		1
CPEB1	ESCA	chr15	83222233	83222233	G	T	Silent		1
CPEB1	LIHC	chr15	83218217	83218217	A	G	Silent		1
CPEB1	READ	chr15	83240213	83240213	C	T	Missense_Mutation	p.R12H	1
CPEB1	STAD	chr15	83215935	83215935	G	A	Silent	p.S484S	1
CPEB1	SKCM	chr15	83218214	83218214	G	A	Silent	p.P390P	1
CPEB1	STAD	chr15	83215935	83215935	G	A	Silent	p.S549S	1
CPEB1	BLCA	chr15	83218237	83218237	C	G	Missense_Mutation	p.D523H	1
CPEB1	HNSC	chr15	83226687	83226687	G	A	Silent	p.P170P	1
CPEB1	LUAD	chr15	83221230	83221230	C	G	Missense_Mutation	p.E465D	1
CPEB1	SKCM	chr15	83296033	83296033	C	T	Missense_Mutation	p.R61Q	1
CPEB1	SKCM	chr15	83226629	83226629	G	A	Missense_Mutation	p.P190S	1
CPEB1	CESC	chr15	83224721	83224721	C	G	Missense_Mutation	p.R253T	1
CPEB1	LGG	chr15	83296072	83296072	G	A	Missense_Mutation	p.A48V	1
CPEB1	STAD	chr15	83218385	83218385	T	G	Missense_Mutation	p.L408F	1
CPEB1	BLCA	chr15	83222716	83222716	C	G	Missense_Mutation		1
CPEB1	ESCA	chr15	83218339	83218340	-	G	Frame_Shift_Ins	p.S424fs	1
CPEB1	LIHC	chr15	83226690	83226690	G	A	Silent		1
CPEB1	SARC	chr15	83297138	83297138	C	T	Missense_Mutation		1
CPEB1	LUAD	chr15	83221230	83221230	C	G	Splice_Site	p.E427_splice	1
CPEB1	SKCM	chr15	83218215	83218215	G	A	Missense_Mutation	p.P390L	1
CPEB1	STAD	chr15	83218385	83218385	T	G	Missense_Mutation	p.L473F	1
CPEB1	BLCA	chr15	83295967	83295967	C	T	Missense_Mutation	p.R116Q	1
CPEB1	HNSC	chr15	83226688	83226688	G	A	Missense_Mutation	p.P170L	1
CPEB1	LUAD	chr15	83226530	83226530	C	A	Missense_Mutation	p.D256Y	1
CPEB1	SKCM	chr15	83226697	83226697	C	T	Missense_Mutation	p.G167E	1
CPEB1	SKCM	chr15	83222244	83222244	C	T	Missense_Mutation	p.G373S	1
CPEB1	CESC	chr15	83226522	83226522	G	C	Silent	p.L198	1
CPEB1	LGG	chr15	83215914	83215914	T	G	Missense_Mutation	p.K518N	1
CPEB1	STAD	chr15	83221347	83221347	G	A	Silent	p.F361F	1
CPEB1	BLCA	chr15	83222700	83222700	G	T	Missense_Mutation		1
CPEB1	ESCA	chr15	83218339	83218340	-	G	Frame_Shift_Ins	p.Q451fs	1
CPEB1	LIHC	chr15	83296065	83296065	A	G	Silent	p.A23A	1
CPEB1	SARC	chr15	83224861	83224861	G	T	Silent		1
CPEB1	LUAD	chr15	83240093	83240093	C	T	Splice_Site		1
CPEB1	SKCM	chr15	83221249	83221249	C	T	Missense_Mutation	p.R319Q	1
CPEB1	STAD	chr15	83296110	83296110	T	G	Missense_Mutation	p.E68D	1
CPEB1	HNSC	chr15	83215266	83215266	C	G	Missense_Mutation	p.Q565H	1
CPEB1	LUAD	chr15	83226674	83226674	G	T	Missense_Mutation	p.P208T	1
CPEB1	SKCM	chr15	83224829	83224829	G	A	Missense_Mutation	p.S244L	1
CPEB1	SKCM	chr15	83221289	83221289	G	A	Missense_Mutation	p.P408S	1
CPEB1	COAD	chr15	83215251	83215251	T	C	Silent	p.L430L	1
CPEB1	STAD	chr15	83218340	83218340	G	T	Silent	p.P423P	1
CPEB1	BLCA	chr15	83296112	83296112	C	G	Missense_Mutation	p.E35Q	1
CPEB1	HNSC	chr15	83215198	83215198	C	A	Missense_Mutation		1
CPEB1	LIHC	chr15	83226572	83226572	T	A	Missense_Mutation	p.S209C	1
CPEB1	LUAD	chr15	83224664	83224664	G	T	Missense_Mutation	p.P299H	1
CPEB1	SKCM	chr15	83224840	83224840	G	A	Silent	p.F138F	1
CPEB1	STAD	chr15	83218340	83218340	G	T	Silent	p.P488P	1
CPEB1	HNSC	chr15	83226644	83226644	C	G	Missense_Mutation	p.D218H	1
CPEB1	LUSC	chr15	83224681	83224681	G	T	Silent	p.L326L	1
CPEB1	SKCM	chr15	83222286	83222286	G	A	Missense_Mutation	p.R359C	1
CPEB1	COAD	chr15	83215978	83215978	C	T	Missense_Mutation	p.R395H	1
CPEB1	STAD	chr15	83218321	83218321	C	T	Missense_Mutation	p.G430S	1
CPEB1	BLCA	chr15	83218237	83218237	C	G	Missense_Mutation	p.D485H	1
CPEB1	HNSC	chr15	83226644	83226644	C	G	Missense_Mutation		1
CPEB1	LIHC	chr15	83218291	83218291	C	-	Frame_Shift_Del	p.A467fs	1
CPEB1	SARC	chr15	83297194	83297194	G	C	Missense_Mutation		1
CPEB1	LUAD	chr15	83240228	83240228	G	C	Missense_Mutation	p.A109G	1
CPEB1	SKCM	chr15	83226697	83226697	C	T	Missense_Mutation	p.G65E	1
CPEB1	UCEC	chr15	83222257	83222257	C	T	Nonsense_Mutation	p.W401*	1
CPEB1	HNSC	chr15	83221346	83221346	C	A	Nonsense_Mutation	p.E427*	1
CPEB1	LUSC	chr15	83218354	83218354	G	T	Missense_Mutation	p.Q484K	1
CPEB1	BLCA	chr15	83296112	83296112	C	G	Missense_Mutation		1
CPEB1	COAD	chr15	83215979	83215979	G	A	Missense_Mutation	p.R395C	1
CPEB1	STAD	chr15	83218272	83218272	T	G	Missense_Mutation	p.N446T	1
CPEB1	BLCA	chr15	83215217	83215217	G	A	Missense_Mutation	p.P544S	1
CPEB1	HNSC	chr15	83226687	83226687	G	A	Silent		1
CPEB1	LIHC	chr15	83218390	83218390	C	-	Frame_Shift_Del	p.V434fs	1
CPEB1	SKCM	chr15	83221289	83221289	G	A	Missense_Mutation	p.P306S	1
CPEB1	LUAD	chr15	83226530	83226530	C	A	Missense_Mutation	p.D223Y	1
CPEB1	SKCM	chr15	83221280	83221280	G	A	Silent	p.L309L	1
CPEB1	HNSC	chr15	83226687	83226688	GG	AA	Missense_Mutation	p.P203L	1
CPEB1	OV	chr15	83240144	83240144	G	T	Missense_Mutation	p.P110H	1
CPEB1	BLCA	chr15	83218237	83218237	C	G	Missense_Mutation		1
CPEB1	COAD	chr15	83218322	83218322	G	A	Silent	p.V354V	1

Copy number variation (CNV) of CPEB1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across CPEB1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
100273	N/A	BI491473	CPEB1	chr15	83279710	-	AP2B1	chr17	33943160	+
59266	N/A	BF337580	CPEB1	chr15	83260005	-	BRD7	chr16	50370478	+
91270	SKCM	TCGA-WE-A8ZM-06A	CPEB1	chr15	83315888	-	CRTC3	chr15	91147617	+
91270	SKCM	TCGA-WE-A8ZM-06A	CPEB1	chr15	83316607	-	CRTC3	chr15	91150610	+
96137	N/A	AA532619	CPEB1	chr15	83260612	+	SET	chr9	131458667	-
96488	N/A	DN919660	CPEB1	chr15	83212206	-	SH3PXD2B	chr5	171843635	+
18953	N/A	AA531431	CPEB1	chr15	83260611	+	TESK1	chr9	35610030	-
61670	N/A	AX187048	EPHA6	chr3	96960626	+	CPEB1	chr15	83281271	-
61670	OV	TCGA-29-1702-01A	MCTP2	chr15	94913409	+	CPEB1	chr15	83296118	-
61673	OV	TCGA-23-1114	ORC2	chr2	201828212	-	CPEB1	chr15	83240282	-
61673	OV	TCGA-23-1114-01B	ORC2	chr2	201828213	-	CPEB1	chr15	83240282	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	CPEB1	0.000362526559615364	0.01
HNSC	CPEB1	0.00358207838761708	0.097
ACC	CPEB1	0.00650675085695161	0.17
READ	CPEB1	0.0230312237411702	0.58
LIHC	CPEB1	0.0420028011453534	1
SARC	CPEB1	0.0474637024995644	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
STAD	CPEB1	0.000469478039354824	0.015
THCA	CPEB1	0.0161645140859265	0.48
BRCA	CPEB1	0.00578532569495529	0.18
UVM	CPEB1	0.0423693334685488	1
OV	CPEB1	9.89363548729021e-06	0.00033
THYM	CPEB1	0.0259354498792387	0.75

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0023434	Chronic Lymphocytic Leukemia	1	CTD_human