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Center for Computational Systems Medicine
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Gene Summary

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Translation studies in PubMed

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Exon Skipping Events

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Expression

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Expression Regulation

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Associated Genes

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Protein 3D Structure

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Protein-Protein Interaction

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Mutations

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Prognostic Analysis

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Gender Association

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Age Association

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Related Drugs

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Related Diseases

Translation Factor: ZAR1L (NCBI Gene ID:646799)


Gene Summary

check button Gene Summary
Gene InformationGene Name: ZAR1L
Gene ID: 646799
Gene Symbol

ZAR1L

Gene ID

646799

Gene Namezygote arrest 1 like
SynonymsZ3CXXC7|ZAR2
Cytomap

13q13.1

Type of Geneprotein-coding
DescriptionZAR1-like proteinzinc finger, 3CxxC-type 7
Modification date20200313
UniProtAcc

A6NP61


check button Child GO biological process term(s) under GO:0006412
GO IDGO term
GO:0006412Translation


check button Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Inferred gene age of translation factor.
GeneInferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
ZAR1L(355.7 - 733]


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Translation Studies in PubMed

check button We searched PubMed using 'ZAR1L[title] AND translation [title] AND human.'
GeneTitlePMID
ZAR1L..


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Exon Skipping Events

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.
all structure

check button Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ENSTExon skip start (DNA)Exon Skip end (DNA)ORF

check button Exon skipping position in the amino acid sequence.
ENSTExon skip start (DNA)Exon Skip end (DNA)Len(transcript seq)Exon skip start (mRNA)Exon Skip end (mRNA)Len(amino acid seq)Exon skip start (AA)Exon Skip end (AA)

check button Potentially (partially) lost protein functional features of UniProt.
UniProtAccExon skip start (AA)Exon Skip end (AA)Function feature start (AA)Function feature end (AA)Functional feature typeFunctional feature desc.


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Expression


check buttonGene expression level across TCGA pancancer
all structure

check buttonGene expression level across GTEx pantissue
all structure

check buttonExpression level of gene isoforms across TCGA pancancer
all structure

check buttonExpression level of gene isoforms across GTEx pantissue
all structure

check buttonCancer(tissue) type-specific expression level of Translation factor using z-score distriution
all structure

check buttonDifferential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)
all structure
Cancer typeTranslation factorFCadj.pval
BRCAZAR1L-1.435526628879740.00130864564001974
LUSCZAR1L-2.580318095547720.00182371710054537
LIHCZAR1L-2.828317429158070.00584076338898049
KICHZAR1L1.404713666733960.0208625823327655
HNSCZAR1L-1.359695909567520.0454587523438197


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Expression Regulation


check buttonTranslation factor expression regulation through miRNA binding
Cancer typeGenemiRNATargetScan binding score (Context++ score percentile)CoefficientPvalue


check buttonTranslation factor expression regulation through methylation in the promoter of Translation factor
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a

check buttonTranslation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a

check buttonTranslation factor expression regulation through copy number variation of Translation factor
Cancer typeGeneCoefficientPvalue

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Associated Genes


check button Strongly correlated genes belong to cellular important gene groups with ZAR1L (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)
Cancer typeGene groupTranslation factorCorrelated geneCoefficientPvalue


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Protein structure


check button Protein 3D structure
Visit iCn3D.


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Protein-Protein Interaction


check button Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure

check buttonOverlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure
check button
* Edge colors based on TCGA cancer types.

check button* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))
all structure
Cancer typeTranslation factorInteracting protein coding geneFCadj.pval
BRCAZAR1LPADI6-3.784990781813570.000129376845570936
BRCAZAR1LGTSF1-1.734230116181860.00014616362609347
THCAZAR1LZAR1-6.31159426254640.000643096429992795
COADZAR1LNPM2-1.358993385988680.00197160243988037
COADZAR1LGTSF12.328743507678310.00355097651481629
KIRPZAR1LCPEB12.393932004808840.00361521635204554
ESCAZAR1LNPM2-6.414488013259060.0048828125
LUADZAR1LSLC10A4-1.663223046541570.00642418213663947
LUSCZAR1LZAR1-4.765965828233080.00753148348807362
ESCAZAR1LLSM14A-3.695866726891260.013671875
LUADZAR1LBTG4-1.522632072133540.0148465704687343
CHOLZAR1LPABPC1L2.783311724942410.01953125
HNSCZAR1LLSM14A-1.434267291222690.0256568653412614
COADZAR1LLSM14A-1.675350094915010.0291509032249451
KIRCZAR1LGTSF1-2.223455132411241.03594308119664e-06
BRCAZAR1LNPM22.336827080306261.21368585808608e-16
LUADZAR1LPABPC1L-2.515830265015241.30692790027182e-05
PRADZAR1LSLC10A4-2.786486617475061.78303573859803e-06
LUSCZAR1LPABPC1L-2.505381712297143.79466966402315e-05
STADZAR1LPABPC1L-2.432454365419924.02145087718964e-06
LIHCZAR1LPABPC1L-2.775624927144046.17267413816717e-05
KICHZAR1LPABPC1L2.225318681877157.49826431274414e-05


check button Protein-protein interactors with this translation factor (BIOGRID-3.4.160)
PPI interactors with ZAR1L
FAM83D, MCL1, CLUH, ANGEL1, CDK5RAP2, FAM73A, PXN, FAM117A, GLCCI1, BCL2L1, HMBOX1, BCL2L11, GPHN, EML3, ELAVL2, SECISBP2L,


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Mutations


check button Clinically associated variants from ClinVar.
GeneChrPositionRefSeqVarSeqRefSeeqVarTypePathogenicDiseaseVarInfo


check button nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.
all structure


check button SNVs and Indels
GeneCancer typeChromosomeStartEndRefSeeqMutSeqMutation typeAAchange# samples
ZAR1LCOADchr133288565432885654TCMissense_Mutationp.T137A10
ZAR1LCOADchr133288565832885658GASilentp.P135P9
ZAR1LLIHCchr133287806432878064GCMissense_Mutationp.D306E3
ZAR1LCOADchr133288482232884822GAMissense_Mutationp.T234I3
ZAR1LUCECchr133287805632878056ACMissense_Mutationp.F309C2
ZAR1LUCECchr133288560732885607CTSilentp.A1522
ZAR1LUCECchr133288580632885806GAMissense_Mutationp.P86L2
ZAR1LUCECchr133288582332885823GASilentp.S802
ZAR1LUCECchr133288586532885865CTSilentp.A662
ZAR1LSARCchr133288605032886050CTMissense_Mutation2
ZAR1LUCECchr133288590432885904CTSilentp.A532
ZAR1LSARCchr133288605932886059CTMissense_Mutation2
ZAR1LBRCAchr133288592432885924GCMissense_Mutationp.P47A2
ZAR1LESCAchr133288552732885527TCMissense_Mutationp.E179G2
ZAR1LCESCchr133288550332885503GAMissense_Mutation2
ZAR1LESCAchr133288552732885527TCMissense_Mutation2
ZAR1LSARCchr133288605032886050CTMissense_Mutationp.V5I2
ZAR1LSARCchr133288605932886059CTMissense_Mutationp.E2K2
ZAR1LCESCchr133287815232878152GCNonsense_Mutation2
ZAR1LLIHCchr133287806432878064GCMissense_Mutation1
ZAR1LCESCchr133288550332885503GAMissense_Mutationp.S187L1
ZAR1LCESCchr133288568132885681GTMissense_Mutationp.P128T1
ZAR1LLIHCchr133287811232878112A-Frame_Shift_Delp.I290fs1
ZAR1LREADchr133287809232878092CTMissense_Mutationp.R297Q1
ZAR1LREADchr133288478232884782CTSilentp.T247T1
ZAR1LCOADchr133288586632885866GAMissense_Mutationp.A66V1
ZAR1LSARCchr133288565432885654TCMissense_Mutation1
ZAR1LCOADchr133288590532885905GAMissense_Mutationp.A53V1
ZAR1LSARCchr133288552932885529CTSilent1
ZAR1LCESCchr133288568132885681GTMissense_Mutation1
ZAR1LESCAchr133288565832885658GASilent1

check buttonCopy number variation (CNV) of ZAR1L
* Click on the image to open the original image in a new window.
all structure

check buttonFusion gene breakpoints (product of the structural variants (SVs)) across ZAR1L
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


check button Fusion genes with this translation factor from FusionGDB2.0.
FusionGDB2 IDDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
79128BRCATCGA-AN-A04D-01AN4BP2L2chr1333101545-ZAR1Lchr1332878159-
79128N/ABM153481SAMM50chr2244385052-ZAR1Lchr1332885919+
102045N/AAA564088ZAR1Lchr1332883150+RPLP2chr11812876-


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Prognostic Analysis


check button Kaplan-Meier plots with logrank tests of overall survival (OS)
all structure
Cancer typeTranslation factorCoefficentHazard ratioWald test pvalLikelihool ratio pvalLogrank test pval# samples


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Translation factor and Gender


check button Differential gene expression between female and male. (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
TGCTZAR1L0.0003752857898602040.011
HNSCZAR1L0.003177862296690380.086
STADZAR1L0.03966956457947091

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Translation factor and Age


check button Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
KIRPZAR1L0.04371689788163621
BRCAZAR1L0.002680588983707050.086
PRADZAR1L0.00119384420820260.039
SKCMZAR1L0.03682080105420471
CESCZAR1L0.04492009396869491
THYMZAR1L0.0380207081719961

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Related Drugs


check button Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)
UniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases


check button Diseases associated with this translation factor.
(DisGeNet 4.0)
Disease IDDisease Name# PubMedsDisease source