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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MRPS5 (NCBI Gene ID:64969)

Gene Summary

Gene Summary

Gene Information	Gene Name: MRPS5
	Gene ID: 64969
	Gene Symbol	MRPS5
	Gene ID	64969
	Gene Name	mitochondrial ribosomal protein S5
	Synonyms	MRP-S5\|S5mt
	Cytomap	2q11.1
	Type of Gene	protein-coding
	Description	28S ribosomal protein S5, mitochondrialmitochondrial 28S ribosomal protein S5mitochondrial small ribosomal subunit protein uS5m
	Modification date	20200313
	UniProtAcc	P82675

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MRPS5	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'MRPS5[title] AND translation [title] AND human.'

Gene	Title	PMID
MRPS5	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000272418	95756130	95756267	Frame-shift
ENST00000272418	95767421	95767468	Frame-shift
ENST00000272418	95770384	95770475	Frame-shift
ENST00000272418	95780810	95780948	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000272418	95780810	95780948	1669	349	486	430	46	92

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P82675	46	92	1	430	Chain	ID=PRO_0000131685;Note=28S ribosomal protein S5%2C mitochondrial

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KICH	MRPS5	1.25108287838437	0.000249803066253662
ESCA	MRPS5	-2.15440118747854	0.0185546875
LUAD	MRPS5	-2.20881945885927	1.77904381378076e-06
LUSC	MRPS5	-7.65956389962319	4.27210217182982e-06

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LIHC	MRPS5	-0.054058901	0.035107354
THYM	MRPS5	0.074980483	0.036988104

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MRPS5 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	MRPS5	PSMC5	0.806047587	4.77E-12
DLBC	Cell metabolism gene	MRPS5	POLR2L	0.808977891	3.48E-12
DLBC	Cell metabolism gene	MRPS5	SNRPD3	0.809423253	3.31E-12
DLBC	Cell metabolism gene	MRPS5	PSMD13	0.809563069	3.26E-12
DLBC	Cell metabolism gene	MRPS5	POLR2F	0.810874068	2.83E-12
DLBC	Cell metabolism gene	MRPS5	SNRPB	0.811300716	2.70E-12
DLBC	Cell metabolism gene	MRPS5	TOMM22	0.812261249	2.43E-12
DLBC	Cell metabolism gene	MRPS5	TIMM13	0.812356974	2.40E-12
DLBC	Cell metabolism gene	MRPS5	SAMM50	0.813177086	2.19E-12
DLBC	Cell metabolism gene	MRPS5	PSMB3	0.824025876	6.27E-13
DLBC	Cell metabolism gene	MRPS5	IDH3B	0.825504936	5.25E-13
DLBC	Cell metabolism gene	MRPS5	EXOSC4	0.832037227	2.35E-13
DLBC	Cell metabolism gene	MRPS5	TIMM10	0.843995202	4.93E-14
DLBC	Cell metabolism gene	MRPS5	PSMB7	0.845886706	3.81E-14
DLBC	Cell metabolism gene	MRPS5	PSMC3	0.849954148	2.15E-14
DLBC	Cell metabolism gene	MRPS5	TIMM50	0.867194	1.58E-15
DLBC	Epifactor	MRPS5	RRP8	0.826558132	4.62E-13
DLBC	Epifactor	MRPS5	EXOSC4	0.832037227	2.35E-13
DLBC	IUPHAR	MRPS5	MFSD2B	0.806539551	4.53E-12
DLBC	TF	MRPS5	PIN1	0.800824838	8.28E-12
DLBC	TF	MRPS5	REXO4	0.805983082	4.81E-12
DLBC	TSG	MRPS5	PIN1	0.800824838	8.28E-12
DLBC	TSG	MRPS5	GADD45GIP1	0.839693436	8.78E-14
DLBC	TSG	MRPS5	PHB	0.854957323	1.04E-14
TGCT	Cell metabolism gene	MRPS5	PSMC5	0.807281339	4.26E-37
THYM	Cell metabolism gene	MRPS5	ITPA	0.802504131	1.10E-28
THYM	Cell metabolism gene	MRPS5	DHRS4L2	0.80326018	8.95E-29
THYM	Cell metabolism gene	MRPS5	SNRPD3	0.803689134	7.96E-29
THYM	Cell metabolism gene	MRPS5	SLC27A5	0.803815603	7.69E-29
THYM	Cell metabolism gene	MRPS5	UROS	0.805920371	4.30E-29
THYM	Cell metabolism gene	MRPS5	DGAT1	0.80594228	4.28E-29
THYM	Cell metabolism gene	MRPS5	TSTA3	0.805982571	4.23E-29
THYM	Cell metabolism gene	MRPS5	POLD1	0.809143941	1.75E-29
THYM	Cell metabolism gene	MRPS5	OAZ1	0.809722272	1.48E-29
THYM	Cell metabolism gene	MRPS5	MTX1	0.810425372	1.21E-29
THYM	Cell metabolism gene	MRPS5	IDH3B	0.81079404	1.09E-29
THYM	Cell metabolism gene	MRPS5	PSMB4	0.811115023	9.98E-30
THYM	Cell metabolism gene	MRPS5	HSD17B10	0.813481713	5.05E-30
THYM	Cell metabolism gene	MRPS5	AAAS	0.813966564	4.39E-30
THYM	Cell metabolism gene	MRPS5	MED18	0.814166619	4.14E-30
THYM	Cell metabolism gene	MRPS5	POLR2I	0.814485177	3.77E-30
THYM	Cell metabolism gene	MRPS5	PMPCA	0.815522629	2.79E-30
THYM	Cell metabolism gene	MRPS5	SNRPF	0.815595863	2.73E-30
THYM	Cell metabolism gene	MRPS5	ATIC	0.818770427	1.06E-30
THYM	Cell metabolism gene	MRPS5	SEC61B	0.820476846	6.37E-31
THYM	Cell metabolism gene	MRPS5	MTMR14	0.820828924	5.72E-31
THYM	Cell metabolism gene	MRPS5	EXOSC4	0.820858218	5.67E-31
THYM	Cell metabolism gene	MRPS5	MED27	0.821163719	5.17E-31
THYM	Cell metabolism gene	MRPS5	PSMD8	0.822993526	2.96E-31
THYM	Cell metabolism gene	MRPS5	PCYT2	0.823593108	2.46E-31
THYM	Cell metabolism gene	MRPS5	PREB	0.823815134	2.30E-31
THYM	Cell metabolism gene	MRPS5	DUT	0.824338913	1.95E-31
THYM	Cell metabolism gene	MRPS5	POLR3K	0.825829708	1.23E-31
THYM	Cell metabolism gene	MRPS5	SNRPD1	0.829018472	4.48E-32
THYM	Cell metabolism gene	MRPS5	EXOSC1	0.829076121	4.40E-32
THYM	Cell metabolism gene	MRPS5	NOP56	0.829646733	3.66E-32
THYM	Cell metabolism gene	MRPS5	PGLS	0.829942193	3.33E-32
THYM	Cell metabolism gene	MRPS5	GCDH	0.829983562	3.29E-32
THYM	Cell metabolism gene	MRPS5	TAZ	0.832239551	1.58E-32
THYM	Cell metabolism gene	MRPS5	SNRPE	0.832252613	1.58E-32
THYM	Cell metabolism gene	MRPS5	NANS	0.833048273	1.22E-32
THYM	Cell metabolism gene	MRPS5	PSMC1	0.833549297	1.03E-32
THYM	Cell metabolism gene	MRPS5	GEMIN7	0.837864752	2.44E-33
THYM	Cell metabolism gene	MRPS5	POLR2H	0.839666547	1.32E-33
THYM	Cell metabolism gene	MRPS5	MVD	0.842450605	5.05E-34
THYM	Cell metabolism gene	MRPS5	GEMIN6	0.843391733	3.63E-34
THYM	Cell metabolism gene	MRPS5	TXN	0.843708035	3.25E-34
THYM	Cell metabolism gene	MRPS5	TOMM22	0.844999365	2.06E-34
THYM	Cell metabolism gene	MRPS5	APOA1	0.84540187	1.78E-34
THYM	Cell metabolism gene	MRPS5	PSMA5	0.848705145	5.41E-35
THYM	Cell metabolism gene	MRPS5	FPGS	0.849170176	4.56E-35
THYM	Cell metabolism gene	MRPS5	SEC61G	0.849834132	3.57E-35
THYM	Cell metabolism gene	MRPS5	PSMD4	0.850734884	2.56E-35
THYM	Cell metabolism gene	MRPS5	PSMB2	0.850909908	2.40E-35
THYM	Cell metabolism gene	MRPS5	PSMB6	0.854711007	5.74E-36
THYM	Cell metabolism gene	MRPS5	POLR2J	0.855727974	3.89E-36
THYM	Cell metabolism gene	MRPS5	NT5M	0.856522532	2.86E-36
THYM	Cell metabolism gene	MRPS5	SUCLG1	0.857124998	2.26E-36
THYM	Cell metabolism gene	MRPS5	TIMM50	0.861354839	4.26E-37
THYM	Cell metabolism gene	MRPS5	PSMA6	0.861610793	3.84E-37
THYM	Cell metabolism gene	MRPS5	LSM2	0.862215846	3.01E-37
THYM	Cell metabolism gene	MRPS5	LSM3	0.864420357	1.22E-37
THYM	Cell metabolism gene	MRPS5	LSM5	0.864483843	1.19E-37
THYM	Cell metabolism gene	MRPS5	TIMM8B	0.864912992	9.99E-38
THYM	Cell metabolism gene	MRPS5	POLD2	0.868690538	2.05E-38
THYM	Cell metabolism gene	MRPS5	SNRPB	0.869229597	1.63E-38
THYM	Cell metabolism gene	MRPS5	WBSCR22	0.8694741	1.47E-38
THYM	Cell metabolism gene	MRPS5	TOMM40	0.873917515	2.10E-39
THYM	Cell metabolism gene	MRPS5	DGUOK	0.878053685	3.23E-40
THYM	Cell metabolism gene	MRPS5	TIMM17B	0.878693444	2.40E-40
THYM	Cell metabolism gene	MRPS5	TIMM13	0.878867758	2.22E-40
THYM	Cell metabolism gene	MRPS5	PSMB10	0.879274325	1.84E-40
THYM	Cell metabolism gene	MRPS5	POLA2	0.882028635	5.00E-41
THYM	Cell metabolism gene	MRPS5	PSMD13	0.88548785	9.33E-42
THYM	Cell metabolism gene	MRPS5	PSMC3	0.885796784	8.01E-42
THYM	Cell metabolism gene	MRPS5	APRT	0.889350866	1.34E-42
THYM	Cell metabolism gene	MRPS5	PAFAH1B3	0.893180692	1.82E-43
THYM	Cell metabolism gene	MRPS5	GALK1	0.894324131	9.88E-44
THYM	Cell metabolism gene	MRPS5	GUK1	0.89455501	8.73E-44
THYM	Cell metabolism gene	MRPS5	PSMA4	0.895850949	4.32E-44
THYM	Cell metabolism gene	MRPS5	PHKG2	0.896029505	3.92E-44
THYM	Cell metabolism gene	MRPS5	PGP	0.896677782	2.75E-44
THYM	Cell metabolism gene	MRPS5	EBP	0.898653596	9.17E-45
THYM	Cell metabolism gene	MRPS5	PSMB7	0.899079211	7.21E-45
THYM	Cell metabolism gene	MRPS5	ACOT8	0.899714858	5.04E-45
THYM	Cell metabolism gene	MRPS5	LSM4	0.906793837	7.73E-47
THYM	Cell metabolism gene	MRPS5	PSMB3	0.910009566	1.04E-47
THYM	Cell metabolism gene	MRPS5	DTYMK	0.911971174	2.93E-48
THYM	Cell metabolism gene	MRPS5	SNRPD2	0.912742778	1.77E-48
THYM	CGC	MRPS5	BCL2L12	0.802264708	1.17E-28
THYM	CGC	MRPS5	POLD1	0.809143941	1.75E-29
THYM	CGC	MRPS5	ATIC	0.818770427	1.06E-30
THYM	CGC	MRPS5	BAX	0.81964593	8.18E-31
THYM	CGC	MRPS5	RBM10	0.822705152	3.23E-31
THYM	CGC	MRPS5	RECQL4	0.839304495	1.50E-33
THYM	CGC	MRPS5	COX6C	0.861789091	3.57E-37
THYM	CGC	MRPS5	TFPT	0.902444295	1.04E-45
THYM	CGC	MRPS5	SDHAF2	0.902907343	7.97E-46
THYM	Epifactor	MRPS5	HIST1H3F	0.800118365	2.09E-28
THYM	Epifactor	MRPS5	LAS1L	0.801547309	1.42E-28
THYM	Epifactor	MRPS5	PRR14	0.808916808	1.86E-29
THYM	Epifactor	MRPS5	HIST1H3C	0.809588452	1.54E-29
THYM	Epifactor	MRPS5	CDK9	0.814443329	3.82E-30
THYM	Epifactor	MRPS5	PKN1	0.814477237	3.78E-30
THYM	Epifactor	MRPS5	HIST1H2BH	0.818228046	1.25E-30
THYM	Epifactor	MRPS5	CCDC101	0.819469799	8.63E-31
THYM	Epifactor	MRPS5	EXOSC4	0.820858218	5.67E-31
THYM	Epifactor	MRPS5	RRP8	0.822237215	3.73E-31
THYM	Epifactor	MRPS5	SS18L2	0.822657146	3.28E-31
THYM	Epifactor	MRPS5	MAZ	0.823552304	2.49E-31
THYM	Epifactor	MRPS5	C17orf49	0.828384931	5.48E-32
THYM	Epifactor	MRPS5	EXOSC1	0.829076121	4.40E-32
THYM	Epifactor	MRPS5	HIRIP3	0.829146257	4.30E-32
THYM	Epifactor	MRPS5	HMG20B	0.83415304	8.46E-33
THYM	Epifactor	MRPS5	SIRT7	0.836445618	3.94E-33
THYM	Epifactor	MRPS5	PRMT7	0.837701904	2.58E-33
THYM	Epifactor	MRPS5	SIRT6	0.840180661	1.11E-33
THYM	Epifactor	MRPS5	H2AFX	0.843071944	4.06E-34
THYM	Epifactor	MRPS5	CXXC1	0.84427963	2.65E-34
THYM	Epifactor	MRPS5	PAF1	0.852088539	1.55E-35
THYM	Epifactor	MRPS5	CDK5	0.862435265	2.75E-37
THYM	Epifactor	MRPS5	TRIM28	0.863437626	1.83E-37
THYM	Epifactor	MRPS5	HIST1H2AJ	0.863583309	1.73E-37
THYM	Epifactor	MRPS5	INO80E	0.867971316	2.78E-38
THYM	Epifactor	MRPS5	PRPF31	0.877921038	3.44E-40
THYM	Epifactor	MRPS5	TAF10	0.879533517	1.63E-40
THYM	Epifactor	MRPS5	ZGPAT	0.881942779	5.21E-41
THYM	Epifactor	MRPS5	ZNHIT1	0.882764049	3.52E-41
THYM	Epifactor	MRPS5	HIST2H2AC	0.883459731	2.51E-41
THYM	Epifactor	MRPS5	PPP4C	0.890765585	6.47E-43
THYM	Epifactor	MRPS5	RUVBL2	0.891399158	4.65E-43
THYM	Epifactor	MRPS5	PPM1G	0.893199252	1.80E-43
THYM	Epifactor	MRPS5	SUV39H1	0.894754643	7.84E-44
THYM	Epifactor	MRPS5	TFPT	0.902444295	1.04E-45
THYM	Epifactor	MRPS5	BRMS1	0.908314918	3.02E-47
THYM	IUPHAR	MRPS5	DPP7	0.803672149	7.99E-29
THYM	IUPHAR	MRPS5	SLC27A5	0.803815603	7.69E-29
THYM	IUPHAR	MRPS5	VRK3	0.805318274	5.09E-29
THYM	IUPHAR	MRPS5	DYRK4	0.80585781	4.38E-29
THYM	IUPHAR	MRPS5	DGAT1	0.80594228	4.28E-29
THYM	IUPHAR	MRPS5	SLC39A3	0.807363168	2.88E-29
THYM	IUPHAR	MRPS5	CTRL	0.808777177	1.94E-29
THYM	IUPHAR	MRPS5	TOP1MT	0.81319509	5.49E-30
THYM	IUPHAR	MRPS5	CDK9	0.814443329	3.82E-30
THYM	IUPHAR	MRPS5	PKN1	0.814477237	3.78E-30
THYM	IUPHAR	MRPS5	TWF2	0.820221622	6.88E-31
THYM	IUPHAR	MRPS5	SIRT7	0.836445618	3.94E-33
THYM	IUPHAR	MRPS5	PRMT7	0.837701904	2.58E-33
THYM	IUPHAR	MRPS5	BIRC5	0.840002534	1.18E-33
THYM	IUPHAR	MRPS5	SIRT6	0.840180661	1.11E-33
THYM	IUPHAR	MRPS5	MVD	0.842450605	5.05E-34
THYM	IUPHAR	MRPS5	PSMB2	0.850909908	2.40E-35
THYM	IUPHAR	MRPS5	ATG4B	0.851665516	1.81E-35
THYM	IUPHAR	MRPS5	PSMB6	0.854711007	5.74E-36
THYM	IUPHAR	MRPS5	NT5M	0.856522532	2.86E-36
THYM	IUPHAR	MRPS5	CDK5	0.862435265	2.75E-37
THYM	IUPHAR	MRPS5	TRIM28	0.863437626	1.83E-37
THYM	IUPHAR	MRPS5	PPIA	0.879085056	2.00E-40
THYM	IUPHAR	MRPS5	SUV39H1	0.894754643	7.84E-44
THYM	IUPHAR	MRPS5	PHKG2	0.896029505	3.92E-44
THYM	Kinase	MRPS5	VRK3	0.805318274	5.09E-29
THYM	Kinase	MRPS5	DYRK4	0.80585781	4.38E-29
THYM	Kinase	MRPS5	ADCK4	0.810691055	1.13E-29
THYM	Kinase	MRPS5	CDK9	0.814443329	3.82E-30
THYM	Kinase	MRPS5	PKN1	0.814477237	3.78E-30
THYM	Kinase	MRPS5	CDK5	0.862435265	2.75E-37
THYM	Kinase	MRPS5	TRIM28	0.863437626	1.83E-37
THYM	Kinase	MRPS5	PHKG2	0.896029505	3.92E-44
THYM	TF	MRPS5	ETV2	0.802692289	1.04E-28
THYM	TF	MRPS5	ZNF672	0.805096754	5.41E-29
THYM	TF	MRPS5	ZNF787	0.806336408	3.84E-29
THYM	TF	MRPS5	GLI4	0.822024152	3.98E-31
THYM	TF	MRPS5	MAZ	0.823552304	2.49E-31
THYM	TF	MRPS5	PREB	0.823815134	2.30E-31
THYM	TF	MRPS5	IRF3	0.827134066	8.15E-32
THYM	TF	MRPS5	ZNF653	0.830677912	2.63E-32
THYM	TF	MRPS5	ZBTB17	0.833474646	1.06E-32
THYM	TF	MRPS5	THAP8	0.833909045	9.17E-33
THYM	TF	MRPS5	HMG20B	0.83415304	8.46E-33
THYM	TF	MRPS5	ZNF394	0.835800005	4.89E-33
THYM	TF	MRPS5	CXXC1	0.84427963	2.65E-34
THYM	TF	MRPS5	MXD3	0.846759483	1.09E-34
THYM	TF	MRPS5	RBCK1	0.868114522	2.62E-38
THYM	TF	MRPS5	DRAP1	0.870092854	1.12E-38
THYM	TF	MRPS5	ZNF668	0.872577597	3.81E-39
THYM	TF	MRPS5	MYPOP	0.873463157	2.58E-39
THYM	TF	MRPS5	ZGPAT	0.881942779	5.21E-41
THYM	TF	MRPS5	GTF3A	0.895043331	6.71E-44
THYM	TF	MRPS5	USF1	0.89975856	4.91E-45
THYM	TF	MRPS5	THYN1	0.902528609	9.95E-46
THYM	TF	MRPS5	PIN1	0.90342108	5.89E-46
THYM	TF	MRPS5	ZNF444	0.904689399	2.77E-46
THYM	TF	MRPS5	ZNF688	0.91075967	6.42E-48
THYM	TSG	MRPS5	PLEKHO1	0.8079564	2.44E-29
THYM	TSG	MRPS5	AIF1	0.809313242	1.67E-29
THYM	TSG	MRPS5	GADD45GIP1	0.812622415	6.48E-30
THYM	TSG	MRPS5	GLTSCR2	0.813983204	4.37E-30
THYM	TSG	MRPS5	MYO1A	0.814710252	3.53E-30
THYM	TSG	MRPS5	BAX	0.81964593	8.18E-31
THYM	TSG	MRPS5	MAD1L1	0.826731051	9.25E-32
THYM	TSG	MRPS5	IRF3	0.827134066	8.15E-32
THYM	TSG	MRPS5	GNB2L1	0.827477447	7.31E-32
THYM	TSG	MRPS5	TSSC4	0.836351838	4.07E-33
THYM	TSG	MRPS5	SIRT6	0.840180661	1.11E-33
THYM	TSG	MRPS5	H2AFX	0.843071944	4.06E-34
THYM	TSG	MRPS5	NPRL2	0.850516495	2.78E-35
THYM	TSG	MRPS5	AIP	0.857979132	1.62E-36
THYM	TSG	MRPS5	PFN1	0.858160501	1.51E-36
THYM	TSG	MRPS5	ZNF668	0.872577597	3.81E-39
THYM	TSG	MRPS5	HTRA2	0.887375334	3.65E-42
THYM	TSG	MRPS5	PIN1	0.90342108	5.89E-46
THYM	TSG	MRPS5	BRMS1	0.908314918	3.02E-47
UCS	Cell metabolism gene	MRPS5	ITPA	0.802504131	1.10E-28
UCS	Cell metabolism gene	MRPS5	DHRS4L2	0.80326018	8.95E-29
UCS	Cell metabolism gene	MRPS5	SNRPD3	0.803689134	7.96E-29
UCS	Cell metabolism gene	MRPS5	SLC27A5	0.803815603	7.69E-29
UCS	Cell metabolism gene	MRPS5	UROS	0.805920371	4.30E-29
UCS	Cell metabolism gene	MRPS5	DGAT1	0.80594228	4.28E-29
UCS	Cell metabolism gene	MRPS5	TSTA3	0.805982571	4.23E-29
UCS	Cell metabolism gene	MRPS5	POLD1	0.809143941	1.75E-29
UCS	Cell metabolism gene	MRPS5	OAZ1	0.809722272	1.48E-29
UCS	Cell metabolism gene	MRPS5	MTX1	0.810425372	1.21E-29
UCS	Cell metabolism gene	MRPS5	IDH3B	0.81079404	1.09E-29
UCS	Cell metabolism gene	MRPS5	PSMB4	0.811115023	9.98E-30
UCS	Cell metabolism gene	MRPS5	HSD17B10	0.813481713	5.05E-30
UCS	Cell metabolism gene	MRPS5	AAAS	0.813966564	4.39E-30
UCS	Cell metabolism gene	MRPS5	MED18	0.814166619	4.14E-30
UCS	Cell metabolism gene	MRPS5	POLR2I	0.814485177	3.77E-30
UCS	Cell metabolism gene	MRPS5	PMPCA	0.815522629	2.79E-30
UCS	Cell metabolism gene	MRPS5	SNRPF	0.815595863	2.73E-30
UCS	Cell metabolism gene	MRPS5	ATIC	0.818770427	1.06E-30
UCS	Cell metabolism gene	MRPS5	SEC61B	0.820476846	6.37E-31
UCS	Cell metabolism gene	MRPS5	MTMR14	0.820828924	5.72E-31
UCS	Cell metabolism gene	MRPS5	EXOSC4	0.820858218	5.67E-31
UCS	Cell metabolism gene	MRPS5	MED27	0.821163719	5.17E-31
UCS	Cell metabolism gene	MRPS5	PSMD8	0.822993526	2.96E-31
UCS	Cell metabolism gene	MRPS5	PCYT2	0.823593108	2.46E-31
UCS	Cell metabolism gene	MRPS5	PREB	0.823815134	2.30E-31
UCS	Cell metabolism gene	MRPS5	DUT	0.824338913	1.95E-31
UCS	Cell metabolism gene	MRPS5	POLR3K	0.825829708	1.23E-31
UCS	Cell metabolism gene	MRPS5	SNRPD1	0.829018472	4.48E-32
UCS	Cell metabolism gene	MRPS5	EXOSC1	0.829076121	4.40E-32
UCS	Cell metabolism gene	MRPS5	NOP56	0.829646733	3.66E-32
UCS	Cell metabolism gene	MRPS5	PGLS	0.829942193	3.33E-32
UCS	Cell metabolism gene	MRPS5	GCDH	0.829983562	3.29E-32
UCS	Cell metabolism gene	MRPS5	TAZ	0.832239551	1.58E-32
UCS	Cell metabolism gene	MRPS5	SNRPE	0.832252613	1.58E-32
UCS	Cell metabolism gene	MRPS5	NANS	0.833048273	1.22E-32
UCS	Cell metabolism gene	MRPS5	PSMC1	0.833549297	1.03E-32
UCS	Cell metabolism gene	MRPS5	GEMIN7	0.837864752	2.44E-33
UCS	Cell metabolism gene	MRPS5	POLR2H	0.839666547	1.32E-33
UCS	Cell metabolism gene	MRPS5	MVD	0.842450605	5.05E-34
UCS	Cell metabolism gene	MRPS5	GEMIN6	0.843391733	3.63E-34
UCS	Cell metabolism gene	MRPS5	TXN	0.843708035	3.25E-34
UCS	Cell metabolism gene	MRPS5	TOMM22	0.844999365	2.06E-34
UCS	Cell metabolism gene	MRPS5	APOA1	0.84540187	1.78E-34
UCS	Cell metabolism gene	MRPS5	PSMA5	0.848705145	5.41E-35
UCS	Cell metabolism gene	MRPS5	FPGS	0.849170176	4.56E-35
UCS	Cell metabolism gene	MRPS5	SEC61G	0.849834132	3.57E-35
UCS	Cell metabolism gene	MRPS5	PSMD4	0.850734884	2.56E-35
UCS	Cell metabolism gene	MRPS5	PSMB2	0.850909908	2.40E-35
UCS	Cell metabolism gene	MRPS5	PSMB6	0.854711007	5.74E-36
UCS	Cell metabolism gene	MRPS5	POLR2J	0.855727974	3.89E-36
UCS	Cell metabolism gene	MRPS5	NT5M	0.856522532	2.86E-36
UCS	Cell metabolism gene	MRPS5	SUCLG1	0.857124998	2.26E-36
UCS	Cell metabolism gene	MRPS5	TIMM50	0.861354839	4.26E-37
UCS	Cell metabolism gene	MRPS5	PSMA6	0.861610793	3.84E-37
UCS	Cell metabolism gene	MRPS5	LSM2	0.862215846	3.01E-37
UCS	Cell metabolism gene	MRPS5	LSM3	0.864420357	1.22E-37
UCS	Cell metabolism gene	MRPS5	LSM5	0.864483843	1.19E-37
UCS	Cell metabolism gene	MRPS5	TIMM8B	0.864912992	9.99E-38
UCS	Cell metabolism gene	MRPS5	POLD2	0.868690538	2.05E-38
UCS	Cell metabolism gene	MRPS5	SNRPB	0.869229597	1.63E-38
UCS	Cell metabolism gene	MRPS5	WBSCR22	0.8694741	1.47E-38
UCS	Cell metabolism gene	MRPS5	TOMM40	0.873917515	2.10E-39
UCS	Cell metabolism gene	MRPS5	DGUOK	0.878053685	3.23E-40
UCS	Cell metabolism gene	MRPS5	TIMM17B	0.878693444	2.40E-40
UCS	Cell metabolism gene	MRPS5	TIMM13	0.878867758	2.22E-40
UCS	Cell metabolism gene	MRPS5	PSMB10	0.879274325	1.84E-40
UCS	Cell metabolism gene	MRPS5	POLA2	0.882028635	5.00E-41
UCS	Cell metabolism gene	MRPS5	PSMD13	0.88548785	9.33E-42
UCS	Cell metabolism gene	MRPS5	PSMC3	0.885796784	8.01E-42
UCS	Cell metabolism gene	MRPS5	APRT	0.889350866	1.34E-42
UCS	Cell metabolism gene	MRPS5	PAFAH1B3	0.893180692	1.82E-43
UCS	Cell metabolism gene	MRPS5	GALK1	0.894324131	9.88E-44
UCS	Cell metabolism gene	MRPS5	GUK1	0.89455501	8.73E-44
UCS	Cell metabolism gene	MRPS5	PSMA4	0.895850949	4.32E-44
UCS	Cell metabolism gene	MRPS5	PHKG2	0.896029505	3.92E-44
UCS	Cell metabolism gene	MRPS5	PGP	0.896677782	2.75E-44
UCS	Cell metabolism gene	MRPS5	EBP	0.898653596	9.17E-45
UCS	Cell metabolism gene	MRPS5	PSMB7	0.899079211	7.21E-45
UCS	Cell metabolism gene	MRPS5	ACOT8	0.899714858	5.04E-45
UCS	Cell metabolism gene	MRPS5	LSM4	0.906793837	7.73E-47
UCS	Cell metabolism gene	MRPS5	PSMB3	0.910009566	1.04E-47
UCS	Cell metabolism gene	MRPS5	DTYMK	0.911971174	2.93E-48
UCS	Cell metabolism gene	MRPS5	SNRPD2	0.912742778	1.77E-48
UCS	CGC	MRPS5	BCL2L12	0.802264708	1.17E-28
UCS	CGC	MRPS5	POLD1	0.809143941	1.75E-29
UCS	CGC	MRPS5	ATIC	0.818770427	1.06E-30
UCS	CGC	MRPS5	BAX	0.81964593	8.18E-31
UCS	CGC	MRPS5	RBM10	0.822705152	3.23E-31
UCS	CGC	MRPS5	RECQL4	0.839304495	1.50E-33
UCS	CGC	MRPS5	COX6C	0.861789091	3.57E-37
UCS	CGC	MRPS5	TFPT	0.902444295	1.04E-45
UCS	CGC	MRPS5	SDHAF2	0.902907343	7.97E-46
UCS	Epifactor	MRPS5	HIST1H3F	0.800118365	2.09E-28
UCS	Epifactor	MRPS5	LAS1L	0.801547309	1.42E-28
UCS	Epifactor	MRPS5	PRR14	0.808916808	1.86E-29
UCS	Epifactor	MRPS5	HIST1H3C	0.809588452	1.54E-29
UCS	Epifactor	MRPS5	CDK9	0.814443329	3.82E-30
UCS	Epifactor	MRPS5	PKN1	0.814477237	3.78E-30
UCS	Epifactor	MRPS5	HIST1H2BH	0.818228046	1.25E-30
UCS	Epifactor	MRPS5	CCDC101	0.819469799	8.63E-31
UCS	Epifactor	MRPS5	EXOSC4	0.820858218	5.67E-31
UCS	Epifactor	MRPS5	RRP8	0.822237215	3.73E-31
UCS	Epifactor	MRPS5	SS18L2	0.822657146	3.28E-31
UCS	Epifactor	MRPS5	MAZ	0.823552304	2.49E-31
UCS	Epifactor	MRPS5	C17orf49	0.828384931	5.48E-32
UCS	Epifactor	MRPS5	EXOSC1	0.829076121	4.40E-32
UCS	Epifactor	MRPS5	HIRIP3	0.829146257	4.30E-32
UCS	Epifactor	MRPS5	HMG20B	0.83415304	8.46E-33
UCS	Epifactor	MRPS5	SIRT7	0.836445618	3.94E-33
UCS	Epifactor	MRPS5	PRMT7	0.837701904	2.58E-33
UCS	Epifactor	MRPS5	SIRT6	0.840180661	1.11E-33
UCS	Epifactor	MRPS5	H2AFX	0.843071944	4.06E-34
UCS	Epifactor	MRPS5	CXXC1	0.84427963	2.65E-34
UCS	Epifactor	MRPS5	PAF1	0.852088539	1.55E-35
UCS	Epifactor	MRPS5	CDK5	0.862435265	2.75E-37
UCS	Epifactor	MRPS5	TRIM28	0.863437626	1.83E-37
UCS	Epifactor	MRPS5	HIST1H2AJ	0.863583309	1.73E-37
UCS	Epifactor	MRPS5	INO80E	0.867971316	2.78E-38
UCS	Epifactor	MRPS5	PRPF31	0.877921038	3.44E-40
UCS	Epifactor	MRPS5	TAF10	0.879533517	1.63E-40
UCS	Epifactor	MRPS5	ZGPAT	0.881942779	5.21E-41
UCS	Epifactor	MRPS5	ZNHIT1	0.882764049	3.52E-41
UCS	Epifactor	MRPS5	HIST2H2AC	0.883459731	2.51E-41
UCS	Epifactor	MRPS5	PPP4C	0.890765585	6.47E-43
UCS	Epifactor	MRPS5	RUVBL2	0.891399158	4.65E-43
UCS	Epifactor	MRPS5	PPM1G	0.893199252	1.80E-43
UCS	Epifactor	MRPS5	SUV39H1	0.894754643	7.84E-44
UCS	Epifactor	MRPS5	TFPT	0.902444295	1.04E-45
UCS	Epifactor	MRPS5	BRMS1	0.908314918	3.02E-47
UCS	IUPHAR	MRPS5	DPP7	0.803672149	7.99E-29
UCS	IUPHAR	MRPS5	SLC27A5	0.803815603	7.69E-29
UCS	IUPHAR	MRPS5	VRK3	0.805318274	5.09E-29
UCS	IUPHAR	MRPS5	DYRK4	0.80585781	4.38E-29
UCS	IUPHAR	MRPS5	DGAT1	0.80594228	4.28E-29
UCS	IUPHAR	MRPS5	SLC39A3	0.807363168	2.88E-29
UCS	IUPHAR	MRPS5	CTRL	0.808777177	1.94E-29
UCS	IUPHAR	MRPS5	TOP1MT	0.81319509	5.49E-30
UCS	IUPHAR	MRPS5	CDK9	0.814443329	3.82E-30
UCS	IUPHAR	MRPS5	PKN1	0.814477237	3.78E-30
UCS	IUPHAR	MRPS5	TWF2	0.820221622	6.88E-31
UCS	IUPHAR	MRPS5	SIRT7	0.836445618	3.94E-33
UCS	IUPHAR	MRPS5	PRMT7	0.837701904	2.58E-33
UCS	IUPHAR	MRPS5	BIRC5	0.840002534	1.18E-33
UCS	IUPHAR	MRPS5	SIRT6	0.840180661	1.11E-33
UCS	IUPHAR	MRPS5	MVD	0.842450605	5.05E-34
UCS	IUPHAR	MRPS5	PSMB2	0.850909908	2.40E-35
UCS	IUPHAR	MRPS5	ATG4B	0.851665516	1.81E-35
UCS	IUPHAR	MRPS5	PSMB6	0.854711007	5.74E-36
UCS	IUPHAR	MRPS5	NT5M	0.856522532	2.86E-36
UCS	IUPHAR	MRPS5	CDK5	0.862435265	2.75E-37
UCS	IUPHAR	MRPS5	TRIM28	0.863437626	1.83E-37
UCS	IUPHAR	MRPS5	PPIA	0.879085056	2.00E-40
UCS	IUPHAR	MRPS5	SUV39H1	0.894754643	7.84E-44
UCS	IUPHAR	MRPS5	PHKG2	0.896029505	3.92E-44
UCS	Kinase	MRPS5	VRK3	0.805318274	5.09E-29
UCS	Kinase	MRPS5	DYRK4	0.80585781	4.38E-29
UCS	Kinase	MRPS5	ADCK4	0.810691055	1.13E-29
UCS	Kinase	MRPS5	CDK9	0.814443329	3.82E-30
UCS	Kinase	MRPS5	PKN1	0.814477237	3.78E-30
UCS	Kinase	MRPS5	CDK5	0.862435265	2.75E-37
UCS	Kinase	MRPS5	TRIM28	0.863437626	1.83E-37
UCS	Kinase	MRPS5	PHKG2	0.896029505	3.92E-44
UCS	TF	MRPS5	ETV2	0.802692289	1.04E-28
UCS	TF	MRPS5	ZNF672	0.805096754	5.41E-29
UCS	TF	MRPS5	ZNF787	0.806336408	3.84E-29
UCS	TF	MRPS5	GLI4	0.822024152	3.98E-31
UCS	TF	MRPS5	MAZ	0.823552304	2.49E-31
UCS	TF	MRPS5	PREB	0.823815134	2.30E-31
UCS	TF	MRPS5	IRF3	0.827134066	8.15E-32
UCS	TF	MRPS5	ZNF653	0.830677912	2.63E-32
UCS	TF	MRPS5	ZBTB17	0.833474646	1.06E-32
UCS	TF	MRPS5	THAP8	0.833909045	9.17E-33
UCS	TF	MRPS5	HMG20B	0.83415304	8.46E-33
UCS	TF	MRPS5	ZNF394	0.835800005	4.89E-33
UCS	TF	MRPS5	CXXC1	0.84427963	2.65E-34
UCS	TF	MRPS5	MXD3	0.846759483	1.09E-34
UCS	TF	MRPS5	RBCK1	0.868114522	2.62E-38
UCS	TF	MRPS5	DRAP1	0.870092854	1.12E-38
UCS	TF	MRPS5	ZNF668	0.872577597	3.81E-39
UCS	TF	MRPS5	MYPOP	0.873463157	2.58E-39
UCS	TF	MRPS5	ZGPAT	0.881942779	5.21E-41
UCS	TF	MRPS5	GTF3A	0.895043331	6.71E-44
UCS	TF	MRPS5	USF1	0.89975856	4.91E-45
UCS	TF	MRPS5	THYN1	0.902528609	9.95E-46
UCS	TF	MRPS5	PIN1	0.90342108	5.89E-46
UCS	TF	MRPS5	ZNF444	0.904689399	2.77E-46
UCS	TF	MRPS5	ZNF688	0.91075967	6.42E-48
UCS	TSG	MRPS5	PLEKHO1	0.8079564	2.44E-29
UCS	TSG	MRPS5	AIF1	0.809313242	1.67E-29
UCS	TSG	MRPS5	GADD45GIP1	0.812622415	6.48E-30
UCS	TSG	MRPS5	GLTSCR2	0.813983204	4.37E-30
UCS	TSG	MRPS5	MYO1A	0.814710252	3.53E-30
UCS	TSG	MRPS5	BAX	0.81964593	8.18E-31
UCS	TSG	MRPS5	MAD1L1	0.826731051	9.25E-32
UCS	TSG	MRPS5	IRF3	0.827134066	8.15E-32
UCS	TSG	MRPS5	GNB2L1	0.827477447	7.31E-32
UCS	TSG	MRPS5	TSSC4	0.836351838	4.07E-33
UCS	TSG	MRPS5	SIRT6	0.840180661	1.11E-33
UCS	TSG	MRPS5	H2AFX	0.843071944	4.06E-34
UCS	TSG	MRPS5	NPRL2	0.850516495	2.78E-35
UCS	TSG	MRPS5	AIP	0.857979132	1.62E-36
UCS	TSG	MRPS5	PFN1	0.858160501	1.51E-36
UCS	TSG	MRPS5	ZNF668	0.872577597	3.81E-39
UCS	TSG	MRPS5	HTRA2	0.887375334	3.65E-42
UCS	TSG	MRPS5	PIN1	0.90342108	5.89E-46
UCS	TSG	MRPS5	BRMS1	0.908314918	3.02E-47

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Protein structure

Protein 3D structure
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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
BRCA	MRPS5	MRPS15	-2.19567551682318	0.000188684660674703
LIHC	MRPS5	MRPS7	1.27029395477208	0.00182077236082954
STAD	MRPS5	MRPS16	-1.64208084987431	0.00239070039242506
LIHC	MRPS5	MRPS18C	-1.25336042046698	0.00251545393492315
COAD	MRPS5	MRPS18C	-3.48505830240365	0.00322914123535157
KIRC	MRPS5	MRPS15	1.11572283836012	0.00361818577801855
PRAD	MRPS5	MRPS9	1.04379115553269	0.00496210155254694
HNSC	MRPS5	MRPS16	-2.01564621821803	0.00518989327406416
KICH	MRPS5	MRPS2	1.26543989555015	0.0114533305168152
THCA	MRPS5	MRPS15	-1.19960602422995	0.0140154883942907
ESCA	MRPS5	MRPS2	-3.20556788084675	0.0244140625
THCA	MRPS5	MRPS11	-3.10694728540962	0.0252226935182201
BLCA	MRPS5	MRPS11	-2.30276998968219	0.040130615234375
THCA	MRPS5	MRPS10	1.33413691764991	1.55171507174296e-05
LUSC	MRPS5	MRPS9	-3.60637641031661	1.82498668910368e-07
LUSC	MRPS5	MRPS2	-2.70930846488508	1.92864354932136e-09
KICH	MRPS5	MRPS35	1.14233082673341	1.96695327758789e-06
LUAD	MRPS5	MRPS9	-1.32894454884901	1.98978698949574e-05
BRCA	MRPS5	MRPS11	-1.24304977976804	2.31302509538916e-07
KIRC	MRPS5	MRPS35	-2.33452405563859	3.58581186640388e-10
LIHC	MRPS5	MRPS2	-1.14771055358828	4.2584580238307e-05
LUSC	MRPS5	MRPS11	-2.9004097541444	5.43966600483641e-07
BRCA	MRPS5	MRPS7	-2.12787460270434	9.33194208595055e-10

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MRPS5

DDX56, ICT1, CUL3, CAND1, MRPS35, MRPL24, MRPS10, TUFM, EEF2, CORO1C, TMEM43, GALNT2, ILF3, UQCRFS1P1, FLOT1, ZMPSTE24, SDHB, C1QBP, TP53, MOV10, NXF1, NOL12, RPL13, TRA2A, RPL6, MRPS2, ZC3H3, RPS8, TRMT10B, HNRNPA1, ZBTB38, ZNF707, LUC7L, MRPS31, MRPS9, MRPS26, PTCD3, MRPS23, MRPS27, DAP3, MRPS18C, MRPS7, MRPS22, MRPS15, MRPS25, MRPS33, MRPS11, MRPS24, RPL23, RPL17, NTRK1, SNX3, MZT1, MRPS34, AURKAIP1, ZBTB48, E4F1, RBM42, PDGFB, HNRNPR, CCDC59, ZNF263, ZFC3H1, RPL18, ZNF331, RPF1, AARS2, ATP5A1, ATP5F1, C14orf2, CHMP2A, DCAF7, EIF2B5, EIF3D, KCTD10, LEO1, MAPKAP1, MED17, MRPL57, MRPL10, MRPL19, MRPL27, MRPL32, MRPL33, MRPL36, MRPL37, MRPL39, MRPL42, MRPS14, MRPS18A, MRPS21, MTOR, GATB, PITRM1, PPP2R1A, PSMC1, PSMD1, PSMD12, PTCD1, SNRPG, TAF2, TAZ, VPS29, WDR61, ZNF598, EFTUD2, RIOK1, HEXIM1, MEPCE, LARP7, RECQL4, MB21D1, FBL, HIST1H3A, RPS6, MRM1, HSPD1, PDK1, TRMT61B, RC3H1, NR2C2, TCF7L2, ALYREF, SNRNP70, nsp8, PLEKHA4, ZC3H18, GRB7, PRKCB, PTPRR, E, ESR1, IMMP2L, ELAVL1, GRSF1, IGF2BP2, ZC3HAV1, CELF1, ACAD9, AUH, C12orf65, C17orf80, C21orf33, C6orf203, C8orf82, MCUR1, CCDC90B, CHCHD1, CLPB, COX15, CRYZ, CS, DDX28, DHX30, EXD2, FASTKD2, FASTKD3, FASTKD5, GFM1, GFM2, HINT2, LONP1, LRPPRC, MCU, CCDC109B, MDH2, METTL15, METTL17, MRPL11, MRPS12, MRRF, MTERF3, MTFMT, MTG1, MTG2, MTIF2, MTIF3, MTRF1, MTRF1L, NGRN, OTC, PMPCA, PMPCB, RMND1, RPUSD3, RPUSD4, SLC25A51, SLIRP, SSBP1, SURF1, TACO1, TBRG4, TEFM, TFAM, C19orf52, TMEM70, TRUB2, TSFM, VWA8, nsp8ab, ORF4a, MAFB, BRD4, Apc2, DNAJA3, DNAJC15, DNAJC19, DNAJC4, HSCB, TULP3, UFL1, DDRGK1, COX8A, PDHA1, FZR1, MAP4K3, ZBTB2, ZNF460, MRPS17, MRPS6, IGF2BP3, SRSF3, YBX1, PRR3, HNRNPU, ZNF485, SRSF6, ZNF556, H1FNT, ZNF689, RPL26, GNL2, RBM47, SULF2, NUPL2, MRPS18B, RPS9, GLTSCR2, ADARB1, ZNF467, ZKSCAN8, GLI4, ABT1, MRPL2, SRSF4, ZNF324B, RBMS2, ZBTB47, ERAL1, MRPL18, RPL10, LCN1, NEIL1, HIST1H2AM, RPL35, APOBEC3D, TMOD1, RPL13A, PRR4, SRP14, RPL4, MCAT, RPL19, RPL36AL, FAHD1, RBMS3, DES, ACTA1, ACTA2, CBX6, ZNF764, ZNF574, SRSF1, SRSF7, FBXW7, FBXO32, KLF12, KLF15, KLF16, KLF8, LHX2, SOX2, TLX2, TLX3, KLF4, SOX15,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MRPS5	COAD	chr2	95753233	95753233	G	-	Frame_Shift_Del	p.R388fs	7
MRPS5	LUAD	chr2	95756262	95756262	C	A	Missense_Mutation	p.G313C	5
MRPS5	KIRP	chr2	95753148	95753148	C	G	Missense_Mutation	p.G416A	4
MRPS5	LUAD	chr2	95766250	95766250	C	A	Missense_Mutation	p.R300S	3
MRPS5	BRCA	chr2	95767455	95767455	C	T	Missense_Mutation	p.G229E	3
MRPS5	PAAD	chr2	95767442	95767442	G	A	Missense_Mutation	p.R264W	3
MRPS5	LUAD	chr2	95774073	95774073	T	G	Missense_Mutation	p.K162Q	3
MRPS5	KIRC	chr2	95775710	95775710	A	T	Silent	p.T118T	3
MRPS5	LUAD	chr2	95753185	95753185	C	A	Missense_Mutation	p.V404F	3
MRPS5	UCEC	chr2	95766260	95766260	C	A	Missense_Mutation	p.R297I	2
MRPS5	LIHC	chr2	95756225	95756225	C	T	Missense_Mutation		2
MRPS5	ESCA	chr2	95770416	95770416	C	T	Silent	p.L244L	2
MRPS5	UCEC	chr2	95773964	95773964	C	T	Nonsense_Mutation	p.W198*	2
MRPS5	BLCA	chr2	95766234	95766234	T	A	Nonsense_Mutation	p.K306*	2
MRPS5	LIHC	chr2	95756225	95756225	C	T	Missense_Mutation	p.R325Q	2
MRPS5	STAD	chr2	95766633	95766633	T	C	Missense_Mutation	p.N273D	2
MRPS5	UCEC	chr2	95775714	95775714	C	A	Missense_Mutation	p.R117I	2
MRPS5	LGG	chr2	95773974	95773974	C	T	Missense_Mutation	p.G195R	2
MRPS5	STAD	chr2	95775728	95775728	T	-	Frame_Shift_Del	p.K112fs	2
MRPS5	LUAD	chr2	95766248	95766248	G	A	Missense_Mutation	p.T301M	2
MRPS5	UCEC	chr2	95775772	95775772	G	T	Missense_Mutation	p.L98M	2
MRPS5	BRCA	chr2	95775737	95775737	T	C	Silent	p.G109	2
MRPS5	LIHC	chr2	95770404	95770404	C	-	Frame_Shift_Del	p.G248fs	2
MRPS5	UCEC	chr2	95780830	95780830	T	C	Silent	p.P86	2
MRPS5	LIHC	chr2	95774012	95774012	T	-	Frame_Shift_Del	p.K184fs	2
MRPS5	SARC	chr2	95753147	95753147	T	A	Silent		2
MRPS5	UCEC	chr2	95780832	95780832	G	T	Missense_Mutation	p.P86T	2
MRPS5	CESC	chr2	95773922	95773922	C	G	Missense_Mutation		2
MRPS5	TGCT	chr2	95753180	95753180	T	C	Silent		2
MRPS5	SARC	chr2	95756198	95756198	G	T	Missense_Mutation		2
MRPS5	CESC	chr2	95775761	95775761	G	A	Silent		2
MRPS5	LGG	chr2	95773974	95773974	C	T	Missense_Mutation		2
MRPS5	TGCT	chr2	95753180	95753180	T	C	Silent	p.K405K	2
MRPS5	CESC	chr2	95775775	95775775	C	T	Missense_Mutation		2
MRPS5	UCEC	chr2	95753290	95753290	G	-	Frame_Shift_Del	p.H369fs	2
MRPS5	ESCA	chr2	95770416	95770416	C	T	Silent		2
MRPS5	LUAD	chr2	95774150	95774150	C	A	Missense_Mutation	p.R136L	2
MRPS5	UCEC	chr2	95756148	95756148	G	A	Missense_Mutation	p.R351C	2
MRPS5	KIRC	chr2	95780928	95780928	T	C	Missense_Mutation	p.T54A	2
MRPS5	SKCM	chr2	95753230	95753230	C	A	Missense_Mutation	p.G389W	2
MRPS5	UCEC	chr2	95766240	95766240	T	C	Missense_Mutation	p.K304E	2
MRPS5	SKCM	chr2	95783666	95783666	G	A	Missense_Mutation	p.S28F	2
MRPS5	LIHC	chr2	95767468	95767468	C	A	Missense_Mutation		2
MRPS5	STAD	chr2	95756174	95756174	A	C	Missense_Mutation	p.M342R	2
MRPS5	BLCA	chr2	95772194	95772194	C	G	Missense_Mutation		1
MRPS5	SKCM	chr2	95772168	95772168	C	T	Silent	p.E224E	1
MRPS5	COAD	chr2	95766251	95766251	C	A	Missense_Mutation	p.R300M	1
MRPS5	STAD	chr2	95780889	95780890	-	T	Frame_Shift_Ins	p.L67fs	1
MRPS5	KIRP	chr2	95753148	95753148	C	G	Missense_Mutation		1
MRPS5	SKCM	chr2	95773969	95773969	G	T	Missense_Mutation	p.N196K	1
MRPS5	COAD	chr2	95774086	95774086	A	G	Silent	p.I157I	1
MRPS5	ESCA	chr2	95780886	95780886	G	A	Nonsense_Mutation	p.Q68X	1
MRPS5	BLCA	chr2	95772194	95772194	C	G	Missense_Mutation	p.E216Q	1
MRPS5	COAD	chr2	95775692	95775692	C	A	Missense_Mutation	p.K124N	1
MRPS5	LIHC	chr2	95767468	95767468	C	A	Missense_Mutation	p.G255V	1
MRPS5	SKCM	chr2	95773978	95773978	C	T	Nonsense_Mutation	p.W193*	1
MRPS5	ESCA	chr2	95766223	95766223	G	T	Silent	p.P309P	1
MRPS5	LGG	chr2	95753150	95753150	C	A	Missense_Mutation	p.Q415H	1
MRPS5	COAD	chr2	95775761	95775761	G	A	Silent	p.G101G	1
MRPS5	SKCM	chr2	95766623	95766623	A	G	Missense_Mutation	p.V276A	1
MRPS5	STAD	chr2	95766226	95766226	T	C	Silent	p.Q308Q	1
MRPS5	HNSC	chr2	95774025	95774025	C	T	Missense_Mutation		1
MRPS5	LUSC	chr2	95770428	95770428	C	A	Silent	p.S240S	1
MRPS5	READ	chr2	95787501	95787501	G	A	Silent	p.P12P	1
MRPS5	LGG	chr2	95756194	95756194	C	A	Missense_Mutation	p.K335N	1
MRPS5	ESCA	chr2	95753228	95753228	C	-	Frame_Shift_Del	p.L391fs	1
MRPS5	SKCM	chr2	95756221	95756221	G	A	Silent	p.L326L	1
MRPS5	STAD	chr2	95780890	95780891	-	T	Frame_Shift_Ins	p.A66fs	1
MRPS5	HNSC	chr2	95772185	95772185	C	G	Missense_Mutation		1
MRPS5	LUSC	chr2	95770424	95770424	G	A	Missense_Mutation	p.R242C	1
MRPS5	LGG	chr2	95775727	95775728	-	T	Frame_Shift_Ins	p.K113fs	1
MRPS5	ESCA	chr2	95766223	95766223	G	T	Silent	p.P309	1
MRPS5	LIHC	chr2	95773940	95773940	G	-	Frame_Shift_Del	p.P206fs	1
MRPS5	SKCM	chr2	95774016	95774016	G	A	Nonsense_Mutation	p.R181*	1
MRPS5	HNSC	chr2	95774025	95774025	C	T	Missense_Mutation	p.E178K	1
MRPS5	OV	chr2	95766251	95766251	C	T	Missense_Mutation	p.R300K	1
MRPS5	SKCM	chr2	95774017	95774017	G	A	Silent	p.D180D	1
MRPS5	ESCA	chr2	95770416	95770416	C	T	Silent	p.L244	1
MRPS5	LIHC	chr2	95774105	95774105	T	-	Frame_Shift_Del	p.N151fs	1
MRPS5	HNSC	chr2	95772185	95772185	C	G	Missense_Mutation	p.D219H	1
MRPS5	OV	chr2	95753174	95753174	G	A	Silent	p.D407	1
MRPS5	SARC	chr2	95753147	95753147	T	A	Silent	p.G416G	1
MRPS5	LGG	chr2	95753150	95753150	C	A	Missense_Mutation		1
MRPS5	SKCM	chr2	95772168	95772168	C	T	Splice_Site	p.E224_splice	1
MRPS5	ESCA	chr2	95780886	95780886	G	A	Nonsense_Mutation	p.Q68*	1
MRPS5	LIHC	chr2	95770462	95770462	A	-	Frame_Shift_Del	p.F229fs	1
MRPS5	KIRC	chr2	95773989	95773989	C	A	Nonsense_Mutation	p.E190X	1
MRPS5	SARC	chr2	95753147	95753147	T	A	Silent	p.G416	1
MRPS5	CESC	chr2	95775775	95775775	C	T	Missense_Mutation	p.E97K	1
MRPS5	LGG	chr2	95756194	95756194	C	A	Missense_Mutation		1
MRPS5	SKCM	chr2	95753238	95753238	G	A	Missense_Mutation	p.S386F	1
MRPS5	CESC	chr2	95773922	95773922	C	G	Missense_Mutation	p.G212A	1
MRPS5	LIHC	chr2	95766582	95766582	T	C	Missense_Mutation		1
MRPS5	STAD	chr2	95775728	95775728	T	-	Frame_Shift_Del		1
MRPS5	ESCA	chr2	95766223	95766223	G	T	Silent		1
MRPS5	ESCA	chr2	95756147	95756147	C	T	Missense_Mutation		1

Copy number variation (CNV) of MRPS5
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MRPS5
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
84957	N/A	BF873231	CD3D	chr11	118212373	-	MRPS5	chr2	95756671	+
84957	BRCA	TCGA-LL-A7T0-01A	LMAN2L	chr2	97399256	-	MRPS5	chr2	95774153	-
100841	N/A	AA580245	MRPS5	chr2	95752952	-	CTIF	chr18	46112667	-
84957	N/A	AX397458	MRPS5	chr2	95774143	+	MRPS5	chr2	95774108	-
76684	PRAD	TCGA-CH-5788-01A	MRPS5	chr2	95766582	-	NEB	chr2	152554162	-
55222	N/A	FN097117	MRPS5	chr2	95753211	-	RP11-81K13.1	chr12	75427319	+
97721	CESC	TCGA-EA-A5FO	MRPS5	chr2	95772168	-	SQSTM1	chr5	179249958	+
87229	N/A	BF765898	MRPS5	chr2	95775693	-	STAT1	chr2	191872330	-
84957	N/A	BM805336	PITPNM2	chr12	123594930	-	MRPS5	chr2	95767470	-
84957	N/A	BG990796	PRKAR2A	chr3	48788257	-	MRPS5	chr2	95781052	-
84957	LUAD	TCGA-95-7947-01A	PRPF8	chr17	1587766	-	MRPS5	chr2	95767468	-
84957	N/A	BM145945	RBFOX1	chr16	6833436	-	MRPS5	chr2	95752955	+
84970	N/A	BM153416	SNX29	chr16	12300233	-	MRPS5	chr2	95752952	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
PAAD	MRPS5	0.0140178782417209	0.39
HNSC	MRPS5	0.0191793909860505	0.52
LUAD	MRPS5	0.0301503900664181	0.78
MESO	MRPS5	0.0388998712516873	0.97
TGCT	MRPS5	0.0497468569594674	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
STAD	MRPS5	0.0209508049785609	0.63
KIRC	MRPS5	0.00111463412027984	0.037
BRCA	MRPS5	0.00563236071164435	0.17
THYM	MRPS5	0.00136876396120614	0.044
SARC	MRPS5	0.0407751409730153	1
CHOL	MRPS5	0.0457664737227647	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0152013	Adenocarcinoma of lung (disorder)	1	CTD_human