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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MRPL41 (NCBI Gene ID:64975)

Gene Summary

Gene Summary

Gene Information	Gene Name: MRPL41
	Gene ID: 64975
	Gene Symbol	MRPL41
	Gene ID	64975
	Gene Name	mitochondrial ribosomal protein L41
	Synonyms	BMRP\|MRP-L27\|MRPL27\|PIG3\|RPML27
	Cytomap	9q34.3
	Type of Gene	protein-coding
	Description	39S ribosomal protein L41, mitochondrial39S ribosomal protein L27 homologL41mtMRP-L27 homologMRP-L41bcl-2-interacting mitochondrial ribosomal protein L41cell proliferation-inducing gene 3 proteinmitochondrial large ribosomal subunit protein mL41pr
	Modification date	20200313
	UniProtAcc	Q8IXM3

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MRPL41	GO:0006412	translation	16024796

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MRPL41	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'MRPL41[title] AND translation [title] AND human.'

Gene	Title	PMID
MRPL41	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
COAD	MRPL41	-2.99561502382389	0.00144392251968384
CHOL	MRPL41	-4.96379377542225	0.00390625
THCA	MRPL41	-3.88188543554269	0.00492925389458784
PRAD	MRPL41	1.31179686307216	4.41809300064344e-05
KICH	MRPL41	1.05103651319563	7.49826431274414e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MRPL41 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
BRCA	Cell metabolism gene	MRPL41	PHPT1	0.815442214	5.22E-291
CHOL	Cell metabolism gene	MRPL41	PSMB7	0.846573038	2.37E-13
CHOL	Cell metabolism gene	MRPL41	SEC61B	0.859103515	4.33E-14
CHOL	Cell metabolism gene	MRPL41	UCK1	0.872562362	5.76E-15
CHOL	Cell metabolism gene	MRPL41	PMPCA	0.878216173	2.30E-15
CHOL	IUPHAR	MRPL41	SLC2A8	0.828489255	2.15E-12
CHOL	TSG	MRPL41	NINJ1	0.815250044	9.23E-12
DLBC	Cell metabolism gene	MRPL41	LYPLA2	0.812347142	2.40E-12
DLBC	Cell metabolism gene	MRPL41	MED27	0.821017811	8.94E-13
DLBC	Epifactor	MRPL41	TAF10	0.815930725	1.61E-12
DLBC	TF	MRPL41	THAP3	0.81829397	1.23E-12
DLBC	TSG	MRPL41	GADD45GIP1	0.807242517	4.20E-12
KICH	Cell metabolism gene	MRPL41	TIMM50	0.802113505	1.24E-21
KICH	Cell metabolism gene	MRPL41	PTGES2	0.823155466	1.36E-23
KICH	Cell metabolism gene	MRPL41	MED27	0.831066112	2.13E-24
KICH	IUPHAR	MRPL41	PTGES2	0.823155466	1.36E-23
KIRP	Cell metabolism gene	MRPL41	PHPT1	0.807689829	1.23E-75
KIRP	Cell metabolism gene	MRPL41	POLR2I	0.831249017	7.45E-84
KIRP	TSG	MRPL41	GADD45GIP1	0.82478366	1.78E-81
MESO	Cell metabolism gene	MRPL41	PTGES2	0.803936104	6.99E-21
MESO	Cell metabolism gene	MRPL41	DPM2	0.805194326	5.47E-21
MESO	IUPHAR	MRPL41	PTGES2	0.803936104	6.99E-21
PAAD	Cell metabolism gene	MRPL41	MIF	0.815385642	7.83E-45
PAAD	Cell metabolism gene	MRPL41	PGLS	0.817262926	3.40E-45
PAAD	Cell metabolism gene	MRPL41	NME3	0.827049415	3.75E-47
PAAD	Cell metabolism gene	MRPL41	DOHH	0.842949078	1.31E-50
PAAD	Epifactor	MRPL41	SIRT6	0.804414423	8.51E-43
PAAD	IUPHAR	MRPL41	SIRT6	0.804414423	8.51E-43
PAAD	Kinase	MRPL41	FASTK	0.808623158	1.46E-43
PAAD	TF	MRPL41	GLI4	0.803808549	1.09E-42
PAAD	TSG	MRPL41	STUB1	0.804185141	9.36E-43
PAAD	TSG	MRPL41	SIRT6	0.804414423	8.51E-43
PCPG	Cell metabolism gene	MRPL41	DPM3	0.80503324	8.07E-44
PCPG	Cell metabolism gene	MRPL41	PFDN6	0.846547623	1.51E-52
PCPG	IUPHAR	MRPL41	CSNK2B	0.803137597	1.80E-43
PCPG	TF	MRPL41	ZNF358	0.828290172	2.02E-48
PCPG	TSG	MRPL41	GADD45GIP1	0.882353444	1.82E-62
PRAD	Cell metabolism gene	MRPL41	ACOT8	0.80409601	7.27E-126
PRAD	Cell metabolism gene	MRPL41	LSM4	0.804726059	3.31E-126
PRAD	Cell metabolism gene	MRPL41	IDH3G	0.808027896	5.08E-128
PRAD	Cell metabolism gene	MRPL41	TIMM17B	0.808150933	4.34E-128
PRAD	Cell metabolism gene	MRPL41	DOHH	0.808607785	2.42E-128
PRAD	Cell metabolism gene	MRPL41	POLR2F	0.814098507	1.90E-131
PRAD	Cell metabolism gene	MRPL41	DPM3	0.824872839	7.45E-138
PRAD	Cell metabolism gene	MRPL41	TIMM13	0.830967118	1.12E-141
PRAD	Cell metabolism gene	MRPL41	GPX4	0.831229717	7.64E-142
PRAD	Cell metabolism gene	MRPL41	PHPT1	0.833732576	1.85E-143
PRAD	Cell metabolism gene	MRPL41	MPST	0.834914094	3.12E-144
PRAD	Cell metabolism gene	MRPL41	B3GAT3	0.8469529	1.80E-152
PRAD	Cell metabolism gene	MRPL41	NME3	0.848671462	1.05E-153
PRAD	Cell metabolism gene	MRPL41	PSMB7	0.848968244	6.41E-154
PRAD	Cell metabolism gene	MRPL41	DPM2	0.859039267	1.72E-161
PRAD	Cell metabolism gene	MRPL41	PGLS	0.8596004	6.27E-162
PRAD	Cell metabolism gene	MRPL41	POLR2I	0.861667551	1.46E-163
PRAD	CGC	MRPL41	HRAS	0.833781095	1.72E-143
PRAD	CGC	MRPL41	MAP2K2	0.836836509	1.67E-145
PRAD	CGC	MRPL41	ASPSCR1	0.854011059	1.22E-157
PRAD	Epifactor	MRPL41	MBD3	0.802356167	6.31E-125
PRAD	Epifactor	MRPL41	SIRT6	0.830128868	3.85E-141
PRAD	Epifactor	MRPL41	TAF10	0.831170891	8.33E-142
PRAD	Epifactor	MRPL41	ZNHIT1	0.83927812	3.86E-147
PRAD	IUPHAR	MRPL41	SIRT6	0.830128868	3.85E-141
PRAD	IUPHAR	MRPL41	HRAS	0.833781095	1.72E-143
PRAD	IUPHAR	MRPL41	MPST	0.834914094	3.12E-144
PRAD	IUPHAR	MRPL41	MAP2K2	0.836836509	1.67E-145
PRAD	IUPHAR	MRPL41	NR2F6	0.870032222	1.86E-170
PRAD	Kinase	MRPL41	MAP2K2	0.836836509	1.67E-145
PRAD	Kinase	MRPL41	FASTK	0.855480076	9.49E-159
PRAD	TF	MRPL41	ZNF688	0.80085339	4.01E-124
PRAD	TF	MRPL41	ZNF414	0.801594171	1.61E-124
PRAD	TF	MRPL41	MBD3	0.802356167	6.31E-125
PRAD	TF	MRPL41	ZNF580	0.818828416	3.30E-134
PRAD	TF	MRPL41	ZNF579	0.842357732	3.03E-149
PRAD	TF	MRPL41	ZNF524	0.851501791	9.02E-156
PRAD	TF	MRPL41	NR2F6	0.870032222	1.86E-170
PRAD	TSG	MRPL41	SIRT6	0.830128868	3.85E-141
PRAD	TSG	MRPL41	GADD45GIP1	0.873660228	1.35E-173
SKCM	Cell metabolism gene	MRPL41	AGPAT2	0.801550325	1.73E-107
SKCM	Cell metabolism gene	MRPL41	PTGES2	0.808896459	6.10E-111
SKCM	Cell metabolism gene	MRPL41	FBXW5	0.825442965	2.68E-119
SKCM	Cell metabolism gene	MRPL41	PHPT1	0.836911213	1.25E-125
SKCM	IUPHAR	MRPL41	PTGES2	0.808896459	6.10E-111
TGCT	IUPHAR	MRPL41	SIGIRR	0.834216125	1.19E-41
THCA	Cell metabolism gene	MRPL41	DPM3	0.80377283	1.17E-130
THCA	Cell metabolism gene	MRPL41	APRT	0.806704637	2.53E-132
THCA	Cell metabolism gene	MRPL41	EXOSC4	0.816645869	3.48E-138
THCA	Cell metabolism gene	MRPL41	MIF	0.826775399	1.55E-144
THCA	Cell metabolism gene	MRPL41	PHPT1	0.838209086	3.20E-152
THCA	Cell metabolism gene	MRPL41	PGLS	0.863541432	1.29E-171
THCA	Epifactor	MRPL41	TAF10	0.813423274	3.02E-136
THCA	Epifactor	MRPL41	EXOSC4	0.816645869	3.48E-138
THCA	Epifactor	MRPL41	ZNHIT1	0.822855194	4.97E-142
THCA	TF	MRPL41	ZNF428	0.820978402	7.48E-141
THCA	TF	MRPL41	ZNF787	0.82482058	2.80E-143
THCA	TF	MRPL41	ZNF688	0.825763443	6.97E-144
THCA	TSG	MRPL41	GADD45GIP1	0.852967354	4.44E-163
THYM	Cell metabolism gene	MRPL41	PSMC5	0.801992611	1.26E-28
THYM	Cell metabolism gene	MRPL41	PSMB6	0.80538041	5.00E-29
THYM	Cell metabolism gene	MRPL41	PSMD4	0.806174433	4.01E-29
THYM	Cell metabolism gene	MRPL41	PTGES2	0.80758524	2.71E-29
THYM	Cell metabolism gene	MRPL41	TIMM8B	0.808205963	2.28E-29
THYM	Cell metabolism gene	MRPL41	PSME2	0.808906161	1.87E-29
THYM	Cell metabolism gene	MRPL41	TBCB	0.812966154	5.86E-30
THYM	Cell metabolism gene	MRPL41	HSD17B10	0.813006183	5.80E-30
THYM	Cell metabolism gene	MRPL41	TOMM40	0.814942592	3.30E-30
THYM	Cell metabolism gene	MRPL41	UROS	0.815662144	2.67E-30
THYM	Cell metabolism gene	MRPL41	PSMC1	0.815933528	2.47E-30
THYM	Cell metabolism gene	MRPL41	EXOSC4	0.817106775	1.75E-30
THYM	Cell metabolism gene	MRPL41	SNRPD2	0.817730116	1.45E-30
THYM	Cell metabolism gene	MRPL41	DGAT1	0.820094371	7.15E-31
THYM	Cell metabolism gene	MRPL41	POLR2F	0.820413368	6.49E-31
THYM	Cell metabolism gene	MRPL41	PSMB10	0.820493243	6.34E-31
THYM	Cell metabolism gene	MRPL41	PFDN5	0.823336214	2.66E-31
THYM	Cell metabolism gene	MRPL41	TIMM13	0.824918925	1.63E-31
THYM	Cell metabolism gene	MRPL41	WBSCR22	0.824976899	1.60E-31
THYM	Cell metabolism gene	MRPL41	ACOT8	0.826558982	9.76E-32
THYM	Cell metabolism gene	MRPL41	FAU	0.827530955	7.19E-32
THYM	Cell metabolism gene	MRPL41	MVD	0.82761396	7.00E-32
THYM	Cell metabolism gene	MRPL41	MIF	0.827921874	6.35E-32
THYM	Cell metabolism gene	MRPL41	PHKG2	0.829414616	3.95E-32
THYM	Cell metabolism gene	MRPL41	UROD	0.830375881	2.90E-32
THYM	Cell metabolism gene	MRPL41	PSMB7	0.832268418	1.57E-32
THYM	Cell metabolism gene	MRPL41	GUK1	0.838518213	1.96E-33
THYM	Cell metabolism gene	MRPL41	MTX1	0.841262052	7.64E-34
THYM	Cell metabolism gene	MRPL41	PSMB3	0.849251385	4.43E-35
THYM	Cell metabolism gene	MRPL41	IDH3G	0.856698256	2.67E-36
THYM	Cell metabolism gene	MRPL41	APRT	0.863164232	2.05E-37
THYM	Cell metabolism gene	MRPL41	PGLS	0.869034159	1.77E-38
THYM	Cell metabolism gene	MRPL41	PHPT1	0.86974725	1.30E-38
THYM	Cell metabolism gene	MRPL41	TIMM50	0.875537151	1.02E-39
THYM	Cell metabolism gene	MRPL41	DPM2	0.877419494	4.33E-40
THYM	Cell metabolism gene	MRPL41	POLR2J	0.880443697	1.06E-40
THYM	Cell metabolism gene	MRPL41	POLR2I	0.902480623	1.02E-45
THYM	Cell metabolism gene	MRPL41	DPM3	0.916392116	1.52E-49
THYM	CGC	MRPL41	ASPSCR1	0.806279726	3.90E-29
THYM	CGC	MRPL41	MGMT	0.813496258	5.03E-30
THYM	CGC	MRPL41	TFPT	0.814688426	3.56E-30
THYM	CGC	MRPL41	RBM10	0.815836393	2.54E-30
THYM	CGC	MRPL41	MAP2K2	0.821563125	4.58E-31
THYM	Epifactor	MRPL41	C17orf49	0.80290665	9.85E-29
THYM	Epifactor	MRPL41	MBD3	0.805748835	4.51E-29
THYM	Epifactor	MRPL41	PAF1	0.813330587	5.28E-30
THYM	Epifactor	MRPL41	ZGPAT	0.813434822	5.12E-30
THYM	Epifactor	MRPL41	TFPT	0.814688426	3.56E-30
THYM	Epifactor	MRPL41	EXOSC4	0.817106775	1.75E-30
THYM	Epifactor	MRPL41	PELP1	0.836889387	3.40E-33
THYM	Epifactor	MRPL41	BRMS1	0.838027651	2.31E-33
THYM	Epifactor	MRPL41	TAF10	0.841820935	6.29E-34
THYM	Epifactor	MRPL41	CCDC101	0.846746305	1.10E-34
THYM	Epifactor	MRPL41	SIRT6	0.864136708	1.38E-37
THYM	Epifactor	MRPL41	PRPF31	0.875105575	1.24E-39
THYM	Epifactor	MRPL41	INO80E	0.881429746	6.65E-41
THYM	Epifactor	MRPL41	ZNHIT1	0.912714503	1.80E-48
THYM	IUPHAR	MRPL41	ATP6V0B	0.800612943	1.83E-28
THYM	IUPHAR	MRPL41	SLC39A3	0.803252574	8.97E-29
THYM	IUPHAR	MRPL41	PSMB6	0.80538041	5.00E-29
THYM	IUPHAR	MRPL41	PTGES2	0.80758524	2.71E-29
THYM	IUPHAR	MRPL41	ATG4B	0.811404044	9.19E-30
THYM	IUPHAR	MRPL41	DGAT1	0.820094371	7.15E-31
THYM	IUPHAR	MRPL41	MAP2K2	0.821563125	4.58E-31
THYM	IUPHAR	MRPL41	MMP24	0.824623659	1.79E-31
THYM	IUPHAR	MRPL41	ADCK5	0.825610501	1.31E-31
THYM	IUPHAR	MRPL41	MVD	0.82761396	7.00E-32
THYM	IUPHAR	MRPL41	PHKG2	0.829414616	3.95E-32
THYM	IUPHAR	MRPL41	SIRT6	0.864136708	1.38E-37
THYM	Kinase	MRPL41	MAP2K2	0.821563125	4.58E-31
THYM	Kinase	MRPL41	ADCK5	0.825610501	1.31E-31
THYM	Kinase	MRPL41	FASTK	0.827668276	6.88E-32
THYM	Kinase	MRPL41	PHKG2	0.829414616	3.95E-32
THYM	TF	MRPL41	THAP8	0.802489324	1.10E-28
THYM	TF	MRPL41	MBD3	0.805748835	4.51E-29
THYM	TF	MRPL41	ZGPAT	0.813434822	5.12E-30
THYM	TF	MRPL41	ZNF428	0.825567756	1.33E-31
THYM	TF	MRPL41	DRAP1	0.836933737	3.35E-33
THYM	TF	MRPL41	ZNF32	0.839660237	1.33E-33
THYM	TF	MRPL41	THAP3	0.846971983	1.01E-34
THYM	TF	MRPL41	ZNF688	0.847703218	7.78E-35
THYM	TF	MRPL41	ZNF524	0.856032765	3.46E-36
THYM	TF	MRPL41	ZNF580	0.863651571	1.68E-37
THYM	TF	MRPL41	GLI4	0.867549504	3.32E-38
THYM	TF	MRPL41	ZNF787	0.868161526	2.56E-38
THYM	TF	MRPL41	THAP7	0.873451614	2.59E-39
THYM	TSG	MRPL41	NPRL2	0.82108004	5.30E-31
THYM	TSG	MRPL41	TSSC4	0.831095697	2.30E-32
THYM	TSG	MRPL41	BRMS1	0.838027651	2.31E-33
THYM	TSG	MRPL41	MAD1L1	0.842047105	5.81E-34
THYM	TSG	MRPL41	GABARAP	0.852764534	1.20E-35
THYM	TSG	MRPL41	SIRT6	0.864136708	1.38E-37
THYM	TSG	MRPL41	GADD45GIP1	0.915581832	2.65E-49
UCEC	Cell metabolism gene	MRPL41	PHPT1	0.831742921	9.34E-53
UCEC	Epifactor	MRPL41	ZNHIT1	0.806899738	2.21E-47
UCS	Cell metabolism gene	MRPL41	PSMC5	0.801992611	1.26E-28
UCS	Cell metabolism gene	MRPL41	PSMB6	0.80538041	5.00E-29
UCS	Cell metabolism gene	MRPL41	PSMD4	0.806174433	4.01E-29
UCS	Cell metabolism gene	MRPL41	PTGES2	0.80758524	2.71E-29
UCS	Cell metabolism gene	MRPL41	TIMM8B	0.808205963	2.28E-29
UCS	Cell metabolism gene	MRPL41	PSME2	0.808906161	1.87E-29
UCS	Cell metabolism gene	MRPL41	TBCB	0.812966154	5.86E-30
UCS	Cell metabolism gene	MRPL41	HSD17B10	0.813006183	5.80E-30
UCS	Cell metabolism gene	MRPL41	TOMM40	0.814942592	3.30E-30
UCS	Cell metabolism gene	MRPL41	UROS	0.815662144	2.67E-30
UCS	Cell metabolism gene	MRPL41	PSMC1	0.815933528	2.47E-30
UCS	Cell metabolism gene	MRPL41	EXOSC4	0.817106775	1.75E-30
UCS	Cell metabolism gene	MRPL41	SNRPD2	0.817730116	1.45E-30
UCS	Cell metabolism gene	MRPL41	DGAT1	0.820094371	7.15E-31
UCS	Cell metabolism gene	MRPL41	POLR2F	0.820413368	6.49E-31
UCS	Cell metabolism gene	MRPL41	PSMB10	0.820493243	6.34E-31
UCS	Cell metabolism gene	MRPL41	PFDN5	0.823336214	2.66E-31
UCS	Cell metabolism gene	MRPL41	TIMM13	0.824918925	1.63E-31
UCS	Cell metabolism gene	MRPL41	WBSCR22	0.824976899	1.60E-31
UCS	Cell metabolism gene	MRPL41	ACOT8	0.826558982	9.76E-32
UCS	Cell metabolism gene	MRPL41	FAU	0.827530955	7.19E-32
UCS	Cell metabolism gene	MRPL41	MVD	0.82761396	7.00E-32
UCS	Cell metabolism gene	MRPL41	MIF	0.827921874	6.35E-32
UCS	Cell metabolism gene	MRPL41	PHKG2	0.829414616	3.95E-32
UCS	Cell metabolism gene	MRPL41	UROD	0.830375881	2.90E-32
UCS	Cell metabolism gene	MRPL41	PSMB7	0.832268418	1.57E-32
UCS	Cell metabolism gene	MRPL41	GUK1	0.838518213	1.96E-33
UCS	Cell metabolism gene	MRPL41	MTX1	0.841262052	7.64E-34
UCS	Cell metabolism gene	MRPL41	PSMB3	0.849251385	4.43E-35
UCS	Cell metabolism gene	MRPL41	IDH3G	0.856698256	2.67E-36
UCS	Cell metabolism gene	MRPL41	APRT	0.863164232	2.05E-37
UCS	Cell metabolism gene	MRPL41	PGLS	0.869034159	1.77E-38
UCS	Cell metabolism gene	MRPL41	PHPT1	0.86974725	1.30E-38
UCS	Cell metabolism gene	MRPL41	TIMM50	0.875537151	1.02E-39
UCS	Cell metabolism gene	MRPL41	DPM2	0.877419494	4.33E-40
UCS	Cell metabolism gene	MRPL41	POLR2J	0.880443697	1.06E-40
UCS	Cell metabolism gene	MRPL41	POLR2I	0.902480623	1.02E-45
UCS	Cell metabolism gene	MRPL41	DPM3	0.916392116	1.52E-49
UCS	CGC	MRPL41	ASPSCR1	0.806279726	3.90E-29
UCS	CGC	MRPL41	MGMT	0.813496258	5.03E-30
UCS	CGC	MRPL41	TFPT	0.814688426	3.56E-30
UCS	CGC	MRPL41	RBM10	0.815836393	2.54E-30
UCS	CGC	MRPL41	MAP2K2	0.821563125	4.58E-31
UCS	Epifactor	MRPL41	C17orf49	0.80290665	9.85E-29
UCS	Epifactor	MRPL41	MBD3	0.805748835	4.51E-29
UCS	Epifactor	MRPL41	PAF1	0.813330587	5.28E-30
UCS	Epifactor	MRPL41	ZGPAT	0.813434822	5.12E-30
UCS	Epifactor	MRPL41	TFPT	0.814688426	3.56E-30
UCS	Epifactor	MRPL41	EXOSC4	0.817106775	1.75E-30
UCS	Epifactor	MRPL41	PELP1	0.836889387	3.40E-33
UCS	Epifactor	MRPL41	BRMS1	0.838027651	2.31E-33
UCS	Epifactor	MRPL41	TAF10	0.841820935	6.29E-34
UCS	Epifactor	MRPL41	CCDC101	0.846746305	1.10E-34
UCS	Epifactor	MRPL41	SIRT6	0.864136708	1.38E-37
UCS	Epifactor	MRPL41	PRPF31	0.875105575	1.24E-39
UCS	Epifactor	MRPL41	INO80E	0.881429746	6.65E-41
UCS	Epifactor	MRPL41	ZNHIT1	0.912714503	1.80E-48
UCS	IUPHAR	MRPL41	ATP6V0B	0.800612943	1.83E-28
UCS	IUPHAR	MRPL41	SLC39A3	0.803252574	8.97E-29
UCS	IUPHAR	MRPL41	PSMB6	0.80538041	5.00E-29
UCS	IUPHAR	MRPL41	PTGES2	0.80758524	2.71E-29
UCS	IUPHAR	MRPL41	ATG4B	0.811404044	9.19E-30
UCS	IUPHAR	MRPL41	DGAT1	0.820094371	7.15E-31
UCS	IUPHAR	MRPL41	MAP2K2	0.821563125	4.58E-31
UCS	IUPHAR	MRPL41	MMP24	0.824623659	1.79E-31
UCS	IUPHAR	MRPL41	ADCK5	0.825610501	1.31E-31
UCS	IUPHAR	MRPL41	MVD	0.82761396	7.00E-32
UCS	IUPHAR	MRPL41	PHKG2	0.829414616	3.95E-32
UCS	IUPHAR	MRPL41	SIRT6	0.864136708	1.38E-37
UCS	Kinase	MRPL41	MAP2K2	0.821563125	4.58E-31
UCS	Kinase	MRPL41	ADCK5	0.825610501	1.31E-31
UCS	Kinase	MRPL41	FASTK	0.827668276	6.88E-32
UCS	Kinase	MRPL41	PHKG2	0.829414616	3.95E-32
UCS	TF	MRPL41	THAP8	0.802489324	1.10E-28
UCS	TF	MRPL41	MBD3	0.805748835	4.51E-29
UCS	TF	MRPL41	ZGPAT	0.813434822	5.12E-30
UCS	TF	MRPL41	ZNF428	0.825567756	1.33E-31
UCS	TF	MRPL41	DRAP1	0.836933737	3.35E-33
UCS	TF	MRPL41	ZNF32	0.839660237	1.33E-33
UCS	TF	MRPL41	THAP3	0.846971983	1.01E-34
UCS	TF	MRPL41	ZNF688	0.847703218	7.78E-35
UCS	TF	MRPL41	ZNF524	0.856032765	3.46E-36
UCS	TF	MRPL41	ZNF580	0.863651571	1.68E-37
UCS	TF	MRPL41	GLI4	0.867549504	3.32E-38
UCS	TF	MRPL41	ZNF787	0.868161526	2.56E-38
UCS	TF	MRPL41	THAP7	0.873451614	2.59E-39
UCS	TSG	MRPL41	NPRL2	0.82108004	5.30E-31
UCS	TSG	MRPL41	TSSC4	0.831095697	2.30E-32
UCS	TSG	MRPL41	BRMS1	0.838027651	2.31E-33
UCS	TSG	MRPL41	MAD1L1	0.842047105	5.81E-34
UCS	TSG	MRPL41	GABARAP	0.852764534	1.20E-35
UCS	TSG	MRPL41	SIRT6	0.864136708	1.38E-37
UCS	TSG	MRPL41	GADD45GIP1	0.915581832	2.65E-49
UVM	Cell metabolism gene	MRPL41	POLR2I	0.806399969	1.78E-19
UVM	Cell metabolism gene	MRPL41	POLR2J	0.825947822	4.16E-21
UVM	TSG	MRPL41	GADD45GIP1	0.82529645	4.76E-21

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
BRCA	MRPL41	MRPL32	-3.7979134181794	0.000134327661287861
STAD	MRPL41	MRPL15	-2.15546608137429	0.000334546435624361
KIRC	MRPL41	MRPL11	-1.04966837625557	0.000354478033746394
LIHC	MRPL41	MRPL13	1.54402472107614	0.000655351190157038
LUAD	MRPL41	MRPL32	-2.1966239418264	0.00121089428940613
ESCA	MRPL41	MRPL47	-2.26373711796715	0.001953125
BLCA	MRPL41	MRPL27	-4.19270554058168	0.00202178955078125
CHOL	MRPL41	MRPL3	-2.68429255990621	0.00390625
ESCA	MRPL41	MRPL3	-4.97897094908275	0.0048828125
COAD	MRPL41	MRPL15	1.17181689924568	0.00513318181037904
ESCA	MRPL41	MRPL13	-1.07746088474995	0.0068359375
COAD	MRPL41	MRPL47	-2.29582381838246	0.00863465666770936
ESCA	MRPL41	MRPL17	-1.18756178214998	0.009765625
STAD	MRPL41	MRPL47	-1.4008685687155	0.0118026207201183
LIHC	MRPL41	MRPL17	-1.06225729770915	0.0124123499319886
STAD	MRPL41	MRPL4	1.4393539135682	0.0279771662317216
KIRC	MRPL41	MRPL32	-2.79664327578899	0.0376051795400881
LIHC	MRPL41	MRPL47	-6.59586850948538	0.0416658979324166
KIRP	MRPL41	MRPL36	1.03588200500181	0.0433286507613957
KIRC	MRPL41	MRPL47	1.74758475364701	1.00533732476669e-06
BRCA	MRPL41	MRPL36	-1.94167827329593	1.14465421352297e-11
PRAD	MRPL41	MRPL11	1.12581653394628	1.15996224044503e-05
BRCA	MRPL41	MRPL27	-1.5584165725499	1.16393956539382e-08
KICH	MRPL41	MRPL15	1.54522142310359	1.19209289550781e-07
STAD	MRPL41	MRPL17	-3.90880705449186	1.49570405483246e-06
LUSC	MRPL41	MRPL15	-4.43702988385305	1.91594862886626e-08
KIRC	MRPL41	MRPL3	1.69955762234244	1.97132191719422e-08
LIHC	MRPL41	MRPL32	-1.20074144698753	2.24402029682138e-06
COAD	MRPL41	MRPL4	2.77705897514473	2.98023223876954e-07
LUAD	MRPL41	MRPL36	-3.29841702586724	3.01758810775006e-09
LUAD	MRPL41	MRPL27	-1.39404329671842	3.44055922076328e-05
LUSC	MRPL41	MRPL27	-1.81809468729316	3.90393047420304e-06
BRCA	MRPL41	MRPL15	-3.82448964360727	5.49451113259074e-14
LUSC	MRPL41	MRPL17	-6.83409683292749	6.93230040561614e-07
LUAD	MRPL41	MRPL47	-1.74990909879567	9.53955602455483e-07

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MRPL41

ICT1, CAND1, MRPL37, MRPL44, MRPL51, MRPL52, MRPL12, MRPS9, MRPL42, MRPS28, MRPL55, MRPL23, MRPL28, MRPL10, MRPL13, MRPL3, ILF3, FUBP1, OGDH, HNRNPA0, FAM3C, TSR1, NONO, ABCD3, PLP2, SOX2, TP53, TRIM63, TRIM55, BTRC, MRPL4, MRPL39, MRPS30, MRPL47, HNRNPL, MRPL50, EXOSC5, MRPL9, Rfx5, Slain1, Bag2, PREPL, MRPL30, MRPL45, NBR1, GADD45GIP1, MRPL27, MRPL32, MRPL40, MRPL1, MALSU1, MRPL49, MRPL46, MRPL20, MRPL48, MRPL11, MRPL16, MRPL38, MRPL24, MRPL15, MRPL35, MRPL57, MRPS18A, MRPL22, MRPL34, MRPL19, MRPL14, MRPL18, MRPL17, CFTR, EFTUD2, ESR2, HEXIM1, LARP7, RECQL4, MB21D1, CDK9, MRM1, HSPD1, PDK1, TRMT61B, AURKAIP1, LTN1, KIAA1429, RC3H1, RC3H2, PHB, NIN, SNRNP70, NFX1, TMED8, PLEKHA4, ZC3H18, HTRA2, IMMP2L, ANLN, AURKB, ACAD9, AUH, C12orf65, C17orf80, C1QBP, C21orf33, C6orf203, C8orf82, CCDC90B, CHCHD1, COX15, FASTKD2, FASTKD3, FASTKD5, GFM1, GFM2, GRSF1, HINT2, LRPPRC, MCU, CCDC109B, MDH2, METTL15, METTL17, MRPS12, MRPS26, MRRF, MTERF3, MTG1, MTG2, MTIF2, MTIF3, MTRF1, MTRF1L, NGRN, PMPCA, PMPCB, RPUSD3, RPUSD4, SLIRP, SSBP1, TACO1, TBRG4, TEFM, TFAM, TMEM70, TRUB2, TSFM, TUFM, VWA8, EXD2, INS, MAFB, NR3C1, DNAJC15, HSCB, SMYD3, MRPS34, TUBGCP4, C14orf169, UFL1, DDRGK1, AARS2, COX4I1, CS, PDHA1, FZR1, MRPL2, RPS9, RBMS2, YBX1, MRPL21, MRPL53, SRSF3, APOBEC3D, H1FNT, RPS8, FAHD1, RPL35, ABT1, RPL10, RPL13, RPL19, SURF6, WIPI1, KLF15, BRD4,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MRPL41	THCA	chr9	140446894	140446894	C	T	Missense_Mutation	p.P121S	2
MRPL41	UCEC	chr9	140446740	140446740	G	T	Missense_Mutation	p.K69N	2
MRPL41	BLCA	chr9	140446923	140446923	C	T	Silent	p.L130L	2
MRPL41	HNSC	chr9	140446898	140446898	C	A	Missense_Mutation	p.T122K	2
MRPL41	SKCM	chr9	140446713	140446713	C	T	Silent	p.F60F	2
MRPL41	BLCA	chr9	140446562	140446562	G	A	Missense_Mutation	p.C10Y	2
MRPL41	HNSC	chr9	140446891	140446891	G	C	Missense_Mutation	p.E120Q	2
MRPL41	HNSC	chr9	140446808	140446808	T	G	Missense_Mutation	p.F92C	2
MRPL41	STAD	chr9	140446797	140446797	C	T	Silent	p.A88A	2
MRPL41	BLCA	chr9	140446839	140446839	G	A	Silent	p.K102K	2
MRPL41	BLCA	chr9	140446833	140446833	C	G	Missense_Mutation		1
MRPL41	CESC	chr9	140446917	140446917	C	T	Silent	p.F128	1
MRPL41	LGG	chr9	140446796	140446796	C	-	Frame_Shift_Del		1
MRPL41	BLCA	chr9	140446923	140446923	C	T	Silent		1
MRPL41	THCA	chr9	140446550	140446550	C	T	Missense_Mutation	p.A6V	1
MRPL41	COAD	chr9	140446782	140446782	G	A	Silent	p.E83E	1
MRPL41	LUSC	chr9	140446840	140446840	G	T	Missense_Mutation	p.D103Y	1
MRPL41	BLCA	chr9	140446562	140446562	G	A	Missense_Mutation		1
MRPL41	THCA	chr9	140446549	140446549	G	T	Missense_Mutation	p.A6S	1
MRPL41	GBM	chr9	140446794	140446794	G	T	Silent		1
MRPL41	PRAD	chr9	140446702	140446702	G	A	Missense_Mutation	p.V57I	1
MRPL41	BLCA	chr9	140446845	140446845	C	T	Silent		1
MRPL41	HNSC	chr9	140446808	140446808	T	G	Missense_Mutation		1
MRPL41	SARC	chr9	140446775	140446775	G	T	Missense_Mutation		1
MRPL41	BLCA	chr9	140446839	140446839	G	A	Silent		1
MRPL41	HNSC	chr9	140446891	140446891	G	C	Missense_Mutation		1
MRPL41	SARC	chr9	140446775	140446775	G	T	Missense_Mutation	p.S81I	1
MRPL41	SKCM	chr9	140446788	140446788	C	T	Silent	p.P85P	1
MRPL41	BLCA	chr9	140446845	140446845	C	T	Silent	p.F104F	1
MRPL41	LGG	chr9	140446796	140446796	C	-	Frame_Shift_Del	p.A88fs	1
MRPL41	TGCT	chr9	140446806	140446806	C	T	Silent		1
MRPL41	BLCA	chr9	140446764	140446764	C	G	Silent	p.L77L	1
MRPL41	LGG	chr9	140446582	140446582	C	T	Nonsense_Mutation	p.R17*	1
MRPL41	THCA	chr9	140446894	140446894	C	T	Missense_Mutation		1
MRPL41	CESC	chr9	140446917	140446917	C	T	Silent		1
MRPL41	LGG	chr9	140446796	140446796	C	-	Frame_Shift_Del	p.A89fs	1

Copy number variation (CNV) of MRPL41
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MRPL41
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
101296	N/A	CF144802	MRPL41	chr9	140447006	+	C10orf11	chr10	77466512	-
55041	N/A	BI859112	MRPL41	chr9	140447007	+	MTO1	chr6	74202530	+
101793	BRCA	TCGA-C8-A12M-01A	MRPL41	chr9	140446929	+	ZNF281	chr1	200378618	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRP	MRPL41	0.000116855393762636	0.0033
SARC	MRPL41	0.040703010120564	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	MRPL41	0.000177934341596674	0.0059
THCA	MRPL41	0.0497376338074023	1
KIRC	MRPL41	0.0234799519387508	0.73
KIRP	MRPL41	0.0362966000525182	1
BRCA	MRPL41	0.0382327375877763	1
SARC	MRPL41	0.0104953941402705	0.34

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source