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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MRPL11 (NCBI Gene ID:65003)

Gene Summary

Gene Summary

Gene Information	Gene Name: MRPL11
	Gene ID: 65003
	Gene Symbol	MRPL11
	Gene ID	65003
	Gene Name	mitochondrial ribosomal protein L11
	Synonyms	CGI-113\|L11MT\|MRP-L11
	Cytomap	11q13.2
	Type of Gene	protein-coding
	Description	39S ribosomal protein L11, mitochondrialmitochondrial large ribosomal subunit protein uL11m
	Modification date	20200313
	UniProtAcc	Q9Y3B7

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MRPL11	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'MRPL11[title] AND translation [title] AND human.'

Gene	Title	PMID
MRPL11	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KIRC	MRPL11	-1.04966837625557	0.000354478033746394
PRAD	MRPL11	1.12581653394628	1.15996224044503e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
GBM	MRPL11	0.34154427	0.014384711

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MRPL11 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	MRPL11	PSMC1	0.802348514	7.06E-12
DLBC	Cell metabolism gene	MRPL11	SNRPE	0.802916917	6.65E-12
DLBC	Cell metabolism gene	MRPL11	PHPT1	0.807854562	3.93E-12
DLBC	Cell metabolism gene	MRPL11	ALDOA	0.808818553	3.54E-12
DLBC	Cell metabolism gene	MRPL11	PMPCA	0.808861156	3.52E-12
DLBC	Cell metabolism gene	MRPL11	FPGS	0.810275379	3.02E-12
DLBC	Cell metabolism gene	MRPL11	TIMM8B	0.811936265	2.51E-12
DLBC	Cell metabolism gene	MRPL11	PFDN5	0.813558587	2.10E-12
DLBC	Cell metabolism gene	MRPL11	LSM2	0.813819972	2.04E-12
DLBC	Cell metabolism gene	MRPL11	DPM2	0.815509704	1.69E-12
DLBC	Cell metabolism gene	MRPL11	MMAB	0.816330457	1.54E-12
DLBC	Cell metabolism gene	MRPL11	VKORC1	0.816669749	1.48E-12
DLBC	Cell metabolism gene	MRPL11	DOHH	0.819944989	1.01E-12
DLBC	Cell metabolism gene	MRPL11	PSMA4	0.825509257	5.25E-13
DLBC	Cell metabolism gene	MRPL11	PHKG2	0.827212115	4.27E-13
DLBC	Cell metabolism gene	MRPL11	ECHS1	0.83240213	2.25E-13
DLBC	Cell metabolism gene	MRPL11	DTYMK	0.833254815	2.02E-13
DLBC	Cell metabolism gene	MRPL11	PMVK	0.833259684	2.02E-13
DLBC	Cell metabolism gene	MRPL11	ACOT8	0.833469578	1.96E-13
DLBC	Cell metabolism gene	MRPL11	POLE4	0.836765277	1.29E-13
DLBC	Cell metabolism gene	MRPL11	TIMM10	0.838462432	1.03E-13
DLBC	Cell metabolism gene	MRPL11	PFDN4	0.839326779	9.21E-14
DLBC	Cell metabolism gene	MRPL11	HSD17B10	0.841771452	6.66E-14
DLBC	Cell metabolism gene	MRPL11	PAFAH1B3	0.844065744	4.88E-14
DLBC	Cell metabolism gene	MRPL11	GFER	0.844692245	4.48E-14
DLBC	Cell metabolism gene	MRPL11	PSMC5	0.845817883	3.84E-14
DLBC	Cell metabolism gene	MRPL11	POLR2H	0.845889247	3.80E-14
DLBC	Cell metabolism gene	MRPL11	MTX1	0.846514548	3.49E-14
DLBC	Cell metabolism gene	MRPL11	SNRPD3	0.849957952	2.15E-14
DLBC	Cell metabolism gene	MRPL11	PGLS	0.850043272	2.13E-14
DLBC	Cell metabolism gene	MRPL11	TOMM22	0.852352763	1.53E-14
DLBC	Cell metabolism gene	MRPL11	IDH3B	0.852558579	1.48E-14
DLBC	Cell metabolism gene	MRPL11	FAU	0.853108391	1.37E-14
DLBC	Cell metabolism gene	MRPL11	PSMD4	0.853349226	1.32E-14
DLBC	Cell metabolism gene	MRPL11	B3GAT3	0.854115178	1.18E-14
DLBC	Cell metabolism gene	MRPL11	PSMB6	0.860440144	4.58E-15
DLBC	Cell metabolism gene	MRPL11	ATP5G1	0.860866025	4.29E-15
DLBC	Cell metabolism gene	MRPL11	LSM4	0.861719962	3.76E-15
DLBC	Cell metabolism gene	MRPL11	PSMB4	0.863102592	3.03E-15
DLBC	Cell metabolism gene	MRPL11	TPI1	0.865538798	2.06E-15
DLBC	Cell metabolism gene	MRPL11	UROD	0.869839766	1.02E-15
DLBC	Cell metabolism gene	MRPL11	TIMM50	0.869942988	1.01E-15
DLBC	Cell metabolism gene	MRPL11	EXOSC4	0.870647838	8.96E-16
DLBC	Cell metabolism gene	MRPL11	PTDSS2	0.872930266	6.10E-16
DLBC	Cell metabolism gene	MRPL11	POLR2I	0.87782445	2.61E-16
DLBC	Cell metabolism gene	MRPL11	POLR2F	0.878731697	2.22E-16
DLBC	Cell metabolism gene	MRPL11	ITPA	0.879888026	1.81E-16
DLBC	Cell metabolism gene	MRPL11	PSMA7	0.880929546	1.50E-16
DLBC	Cell metabolism gene	MRPL11	PGP	0.881291614	1.40E-16
DLBC	Cell metabolism gene	MRPL11	SNRPB	0.888723864	3.44E-17
DLBC	Cell metabolism gene	MRPL11	MIF	0.893143004	1.42E-17
DLBC	Cell metabolism gene	MRPL11	SNRPD2	0.899853739	3.44E-18
DLBC	Cell metabolism gene	MRPL11	TIMM13	0.909468778	3.76E-19
DLBC	Cell metabolism gene	MRPL11	PSMD13	0.90951413	3.72E-19
DLBC	Cell metabolism gene	MRPL11	NME2	0.909550664	3.68E-19
DLBC	Cell metabolism gene	MRPL11	POLR2L	0.912045069	1.99E-19
DLBC	Cell metabolism gene	MRPL11	PSMC3	0.915198224	8.90E-20
DLBC	Cell metabolism gene	MRPL11	PSMB3	0.932785578	5.14E-22
DLBC	CGC	MRPL11	COX6C	0.804462329	5.65E-12
DLBC	CGC	MRPL11	TFPT	0.819530335	1.06E-12
DLBC	CGC	MRPL11	NTHL1	0.878153259	2.46E-16
DLBC	CGC	MRPL11	HRAS	0.893725349	1.26E-17
DLBC	Epifactor	MRPL11	SIRT6	0.818440831	1.21E-12
DLBC	Epifactor	MRPL11	TFPT	0.819530335	1.06E-12
DLBC	Epifactor	MRPL11	RRP8	0.820115284	9.93E-13
DLBC	Epifactor	MRPL11	ZNHIT1	0.82577589	5.08E-13
DLBC	Epifactor	MRPL11	RUVBL2	0.841854251	6.58E-14
DLBC	Epifactor	MRPL11	PRPF31	0.84823833	2.74E-14
DLBC	Epifactor	MRPL11	PPP4C	0.848818302	2.53E-14
DLBC	Epifactor	MRPL11	RBX1	0.85118591	1.81E-14
DLBC	Epifactor	MRPL11	DMAP1	0.856009503	8.94E-15
DLBC	Epifactor	MRPL11	FBL	0.870346118	9.42E-16
DLBC	Epifactor	MRPL11	EXOSC4	0.870647838	8.96E-16
DLBC	Epifactor	MRPL11	MBD3	0.884006275	8.47E-17
DLBC	Epifactor	MRPL11	BRMS1	0.891150778	2.13E-17
DLBC	IUPHAR	MRPL11	SLC25A26	0.813222777	2.18E-12
DLBC	IUPHAR	MRPL11	VKORC1	0.816669749	1.48E-12
DLBC	IUPHAR	MRPL11	SIRT6	0.818440831	1.21E-12
DLBC	IUPHAR	MRPL11	SLC25A3	0.822166513	7.81E-13
DLBC	IUPHAR	MRPL11	PHKG2	0.827212115	4.27E-13
DLBC	IUPHAR	MRPL11	PMVK	0.833259684	2.02E-13
DLBC	IUPHAR	MRPL11	BIRC5	0.842518906	6.02E-14
DLBC	IUPHAR	MRPL11	PSMB6	0.860440144	4.58E-15
DLBC	IUPHAR	MRPL11	HRAS	0.893725349	1.26E-17
DLBC	Kinase	MRPL11	PHKG2	0.827212115	4.27E-13
DLBC	TF	MRPL11	IRF3	0.803297462	6.39E-12
DLBC	TF	MRPL11	ZNF444	0.814033238	1.99E-12
DLBC	TF	MRPL11	THAP3	0.840834023	7.55E-14
DLBC	TF	MRPL11	THAP4	0.841094546	7.29E-14
DLBC	TF	MRPL11	THAP7	0.861379482	3.96E-15
DLBC	TF	MRPL11	PIN1	0.876358862	3.38E-16
DLBC	TF	MRPL11	MBD3	0.884006275	8.47E-17
DLBC	TF	MRPL11	NME2	0.909550664	3.68E-19
DLBC	TSG	MRPL11	IRF3	0.803297462	6.39E-12
DLBC	TSG	MRPL11	SIRT6	0.818440831	1.21E-12
DLBC	TSG	MRPL11	PARK7	0.84833627	2.71E-14
DLBC	TSG	MRPL11	PIN1	0.876358862	3.38E-16
DLBC	TSG	MRPL11	PHB	0.883280699	9.70E-17
DLBC	TSG	MRPL11	TSSC4	0.889627588	2.88E-17
DLBC	TSG	MRPL11	BRMS1	0.891150778	2.13E-17
DLBC	TSG	MRPL11	GADD45GIP1	0.922103352	1.36E-20
GBM	Cell metabolism gene	MRPL11	LSM3	0.802075754	6.66E-40
GBM	Cell metabolism gene	MRPL11	LSM1	0.804559438	2.55E-40
GBM	Cell metabolism gene	MRPL11	PFDN5	0.817021055	1.67E-42
GBM	Cell metabolism gene	MRPL11	SNRPB	0.826457701	2.84E-44
GBM	Cell metabolism gene	MRPL11	SNRPD2	0.837518049	1.74E-46
GBM	Cell metabolism gene	MRPL11	DGUOK	0.837573288	1.69E-46
GBM	Cell metabolism gene	MRPL11	NME2	0.839348913	7.21E-47
GBM	Cell metabolism gene	MRPL11	DPM3	0.840046243	5.14E-47
GBM	Cell metabolism gene	MRPL11	PSMA5	0.841120819	3.04E-47
GBM	Cell metabolism gene	MRPL11	DTYMK	0.843132815	1.13E-47
GBM	Cell metabolism gene	MRPL11	NME1	0.845743491	3.04E-48
GBM	Cell metabolism gene	MRPL11	FAU	0.846847965	1.74E-48
GBM	Cell metabolism gene	MRPL11	ZNRD1	0.853935393	4.25E-50
GBM	Cell metabolism gene	MRPL11	TIMM8B	0.859611865	1.88E-51
GBM	Cell metabolism gene	MRPL11	PSMB4	0.860091708	1.44E-51
GBM	Cell metabolism gene	MRPL11	PSMA7	0.864391874	1.23E-52
GBM	Cell metabolism gene	MRPL11	LSM2	0.875937523	1.06E-55
GBM	Cell metabolism gene	MRPL11	PSMB3	0.883858331	5.52E-58
GBM	Cell metabolism gene	MRPL11	SNRPG	0.920619288	2.45E-71
GBM	CGC	MRPL11	SDHAF2	0.809379968	3.81E-41
GBM	Epifactor	MRPL11	ZNHIT1	0.812050157	1.30E-41
GBM	Epifactor	MRPL11	PPP4C	0.821869599	2.12E-43
GBM	Epifactor	MRPL11	DPY30	0.825064046	5.27E-44
GBM	TF	MRPL11	NME2	0.839348913	7.21E-47
GBM	TSG	MRPL11	NME1	0.845743491	3.04E-48
LGG	Epifactor	MRPL11	BRMS1	0.828281333	6.21E-135
LGG	TSG	MRPL11	BRMS1	0.828281333	6.21E-135
MESO	Epifactor	MRPL11	BRMS1	0.830323903	2.70E-23
MESO	TSG	MRPL11	BRMS1	0.830323903	2.70E-23
OV	Cell metabolism gene	MRPL11	FAU	0.80257717	1.26E-70
READ	TSG	MRPL11	PHB	0.811440056	9.06E-26
TGCT	Cell metabolism gene	MRPL11	PSMA5	0.808823703	2.44E-37
TGCT	Cell metabolism gene	MRPL11	PSMB6	0.833975296	1.32E-41
TGCT	Cell metabolism gene	MRPL11	PSMA7	0.859564132	9.39E-47
TGCT	IUPHAR	MRPL11	SLC35B1	0.826276098	3.15E-40
TGCT	IUPHAR	MRPL11	PSMB6	0.833975296	1.32E-41
TGCT	TSG	MRPL11	PHB	0.826591383	2.78E-40
THCA	Cell metabolism gene	MRPL11	LSM2	0.819645847	5.04E-140
THYM	Cell metabolism gene	MRPL11	POLR2L	0.800008515	2.16E-28
THYM	Cell metabolism gene	MRPL11	GEMIN6	0.800670496	1.80E-28
THYM	Cell metabolism gene	MRPL11	DOHH	0.800788925	1.75E-28
THYM	Cell metabolism gene	MRPL11	NUDT2	0.80278865	1.02E-28
THYM	Cell metabolism gene	MRPL11	GCDH	0.803300883	8.85E-29
THYM	Cell metabolism gene	MRPL11	SLC25A11	0.806060041	4.14E-29
THYM	Cell metabolism gene	MRPL11	ATP5G1	0.806106042	4.09E-29
THYM	Cell metabolism gene	MRPL11	PHKG2	0.806242841	3.94E-29
THYM	Cell metabolism gene	MRPL11	TIMM17B	0.807016642	3.17E-29
THYM	Cell metabolism gene	MRPL11	PAFAH1B3	0.808665233	2.00E-29
THYM	Cell metabolism gene	MRPL11	NANS	0.809695829	1.49E-29
THYM	Cell metabolism gene	MRPL11	PSMB2	0.80983302	1.44E-29
THYM	Cell metabolism gene	MRPL11	POLR2J	0.81053379	1.18E-29
THYM	Cell metabolism gene	MRPL11	DGUOK	0.810902364	1.06E-29
THYM	Cell metabolism gene	MRPL11	PSMB10	0.81145086	9.07E-30
THYM	Cell metabolism gene	MRPL11	TBCB	0.81217977	7.36E-30
THYM	Cell metabolism gene	MRPL11	HSD17B10	0.812934881	5.92E-30
THYM	Cell metabolism gene	MRPL11	PTGES2	0.813365838	5.22E-30
THYM	Cell metabolism gene	MRPL11	SRM	0.813794704	4.61E-30
THYM	Cell metabolism gene	MRPL11	IDH3G	0.814198696	4.10E-30
THYM	Cell metabolism gene	MRPL11	PIGU	0.814223944	4.07E-30
THYM	Cell metabolism gene	MRPL11	GMPPA	0.81495309	3.29E-30
THYM	Cell metabolism gene	MRPL11	PSMA4	0.816567289	2.05E-30
THYM	Cell metabolism gene	MRPL11	SMPD2	0.817362333	1.62E-30
THYM	Cell metabolism gene	MRPL11	POLA2	0.817616925	1.50E-30
THYM	Cell metabolism gene	MRPL11	GEMIN7	0.818181831	1.27E-30
THYM	Cell metabolism gene	MRPL11	PSMC1	0.818520908	1.15E-30
THYM	Cell metabolism gene	MRPL11	IMPDH2	0.819823966	7.76E-31
THYM	Cell metabolism gene	MRPL11	PSMA5	0.819871764	7.64E-31
THYM	Cell metabolism gene	MRPL11	HMOX2	0.82100394	5.43E-31
THYM	Cell metabolism gene	MRPL11	ALG3	0.821090769	5.29E-31
THYM	Cell metabolism gene	MRPL11	PSMD9	0.822975298	2.97E-31
THYM	Cell metabolism gene	MRPL11	PSMD4	0.824363783	1.94E-31
THYM	Cell metabolism gene	MRPL11	POLR2F	0.824600567	1.80E-31
THYM	Cell metabolism gene	MRPL11	MMAB	0.825060177	1.56E-31
THYM	Cell metabolism gene	MRPL11	PSMD8	0.826993844	8.52E-32
THYM	Cell metabolism gene	MRPL11	POLR3K	0.827658601	6.90E-32
THYM	Cell metabolism gene	MRPL11	NOP56	0.827770712	6.66E-32
THYM	Cell metabolism gene	MRPL11	HMBS	0.828361959	5.52E-32
THYM	Cell metabolism gene	MRPL11	SNRPD3	0.828854964	4.72E-32
THYM	Cell metabolism gene	MRPL11	PSME1	0.829203612	4.22E-32
THYM	Cell metabolism gene	MRPL11	PGP	0.829541547	3.79E-32
THYM	Cell metabolism gene	MRPL11	PSMB6	0.829598287	3.72E-32
THYM	Cell metabolism gene	MRPL11	TOMM22	0.831006446	2.37E-32
THYM	Cell metabolism gene	MRPL11	SEC61G	0.83238341	1.51E-32
THYM	Cell metabolism gene	MRPL11	SNRPE	0.832578823	1.42E-32
THYM	Cell metabolism gene	MRPL11	MTX1	0.832649216	1.39E-32
THYM	Cell metabolism gene	MRPL11	UROS	0.834082327	8.66E-33
THYM	Cell metabolism gene	MRPL11	GALK1	0.834420137	7.74E-33
THYM	Cell metabolism gene	MRPL11	EBP	0.838042209	2.30E-33
THYM	Cell metabolism gene	MRPL11	IDH3B	0.84318578	3.90E-34
THYM	Cell metabolism gene	MRPL11	LCMT1	0.843222962	3.85E-34
THYM	Cell metabolism gene	MRPL11	GUK1	0.843247228	3.82E-34
THYM	Cell metabolism gene	MRPL11	SNRPD1	0.844904171	2.13E-34
THYM	Cell metabolism gene	MRPL11	SNRPB	0.845654027	1.63E-34
THYM	Cell metabolism gene	MRPL11	GFER	0.846708282	1.12E-34
THYM	Cell metabolism gene	MRPL11	POLR2E	0.846789724	1.08E-34
THYM	Cell metabolism gene	MRPL11	TOMM40	0.84702262	9.96E-35
THYM	Cell metabolism gene	MRPL11	EXOSC5	0.84718593	9.39E-35
THYM	Cell metabolism gene	MRPL11	UROD	0.847233874	9.23E-35
THYM	Cell metabolism gene	MRPL11	LSM3	0.849861373	3.54E-35
THYM	Cell metabolism gene	MRPL11	LSM4	0.853645582	8.61E-36
THYM	Cell metabolism gene	MRPL11	MED19	0.855039537	5.06E-36
THYM	Cell metabolism gene	MRPL11	PMPCA	0.85521088	4.74E-36
THYM	Cell metabolism gene	MRPL11	SSR2	0.855909119	3.63E-36
THYM	Cell metabolism gene	MRPL11	PFDN5	0.858505822	1.32E-36
THYM	Cell metabolism gene	MRPL11	FPGS	0.866297565	5.62E-38
THYM	Cell metabolism gene	MRPL11	PSMC5	0.868120317	2.61E-38
THYM	Cell metabolism gene	MRPL11	POLR2I	0.871401931	6.37E-39
THYM	Cell metabolism gene	MRPL11	TIMM10	0.871498635	6.11E-39
THYM	Cell metabolism gene	MRPL11	OAZ1	0.872247712	4.40E-39
THYM	Cell metabolism gene	MRPL11	ITPA	0.874613015	1.54E-39
THYM	Cell metabolism gene	MRPL11	APRT	0.875766193	9.19E-40
THYM	Cell metabolism gene	MRPL11	POLR2H	0.876385618	6.94E-40
THYM	Cell metabolism gene	MRPL11	DTYMK	0.878055551	3.23E-40
THYM	Cell metabolism gene	MRPL11	PGLS	0.880796874	8.98E-41
THYM	Cell metabolism gene	MRPL11	TALDO1	0.881222981	7.34E-41
THYM	Cell metabolism gene	MRPL11	FAU	0.881477496	6.50E-41
THYM	Cell metabolism gene	MRPL11	PSMB1	0.882987401	3.16E-41
THYM	Cell metabolism gene	MRPL11	MVD	0.883661288	2.28E-41
THYM	Cell metabolism gene	MRPL11	DPM2	0.887453578	3.51E-42
THYM	Cell metabolism gene	MRPL11	LSM2	0.889684808	1.13E-42
THYM	Cell metabolism gene	MRPL11	PSMD13	0.894876993	7.34E-44
THYM	Cell metabolism gene	MRPL11	ACOT8	0.90220353	1.20E-45
THYM	Cell metabolism gene	MRPL11	POLD2	0.902538658	9.89E-46
THYM	Cell metabolism gene	MRPL11	TIMM50	0.902824811	8.36E-46
THYM	Cell metabolism gene	MRPL11	PSMB3	0.903862968	4.53E-46
THYM	Cell metabolism gene	MRPL11	EXOSC4	0.903935491	4.34E-46
THYM	Cell metabolism gene	MRPL11	PSMB7	0.906814307	7.63E-47
THYM	Cell metabolism gene	MRPL11	SLC27A5	0.90795924	3.76E-47
THYM	Cell metabolism gene	MRPL11	TIMM8B	0.919059083	2.36E-50
THYM	Cell metabolism gene	MRPL11	PSMC3	0.929464331	8.38E-54
THYM	Cell metabolism gene	MRPL11	SNRPD2	0.934658327	9.95E-56
THYM	Cell metabolism gene	MRPL11	TIMM13	0.946696138	7.05E-61
THYM	CGC	MRPL11	MGMT	0.817615238	1.50E-30
THYM	CGC	MRPL11	MAP2K2	0.829610976	3.71E-32
THYM	CGC	MRPL11	ASPSCR1	0.839291595	1.50E-33
THYM	CGC	MRPL11	RBM10	0.861286861	4.37E-37
THYM	CGC	MRPL11	SDHAF2	0.890319094	8.15E-43
THYM	CGC	MRPL11	TFPT	0.893469032	1.56E-43
THYM	Epifactor	MRPL11	INO80E	0.805919866	4.31E-29
THYM	Epifactor	MRPL11	PPM1G	0.809200706	1.72E-29
THYM	Epifactor	MRPL11	MCRS1	0.814444286	3.82E-30
THYM	Epifactor	MRPL11	TRIM28	0.818612892	1.12E-30
THYM	Epifactor	MRPL11	LAS1L	0.822397111	3.55E-31
THYM	Epifactor	MRPL11	CXXC1	0.822623725	3.31E-31
THYM	Epifactor	MRPL11	PAF1	0.83282143	1.31E-32
THYM	Epifactor	MRPL11	EXOSC5	0.84718593	9.39E-35
THYM	Epifactor	MRPL11	DMAP1	0.850475162	2.82E-35
THYM	Epifactor	MRPL11	RRP8	0.85204498	1.57E-35
THYM	Epifactor	MRPL11	ZNHIT1	0.855073361	5.00E-36
THYM	Epifactor	MRPL11	C17orf49	0.860325875	6.42E-37
THYM	Epifactor	MRPL11	TAF10	0.871539645	6.00E-39
THYM	Epifactor	MRPL11	SIRT6	0.883877826	2.05E-41
THYM	Epifactor	MRPL11	PRMT1	0.888844835	1.73E-42
THYM	Epifactor	MRPL11	RUVBL2	0.891824683	3.72E-43
THYM	Epifactor	MRPL11	PPP4C	0.892084842	3.25E-43
THYM	Epifactor	MRPL11	TFPT	0.893469032	1.56E-43
THYM	Epifactor	MRPL11	NOC2L	0.893889286	1.25E-43
THYM	Epifactor	MRPL11	MBD3	0.900061858	4.13E-45
THYM	Epifactor	MRPL11	EXOSC4	0.903935491	4.34E-46
THYM	Epifactor	MRPL11	BRMS1	0.905975451	1.27E-46
THYM	Epifactor	MRPL11	PRPF31	0.920479847	8.51E-51
THYM	Epifactor	MRPL11	FBL	0.931936944	1.06E-54
THYM	IUPHAR	MRPL11	MPDU1	0.801874689	1.30E-28
THYM	IUPHAR	MRPL11	SLC25A11	0.806060041	4.14E-29
THYM	IUPHAR	MRPL11	PHKG2	0.806242841	3.94E-29
THYM	IUPHAR	MRPL11	PSMB2	0.80983302	1.44E-29
THYM	IUPHAR	MRPL11	MMP24	0.810266455	1.27E-29
THYM	IUPHAR	MRPL11	PPIA	0.810346954	1.24E-29
THYM	IUPHAR	MRPL11	PTGES2	0.813365838	5.22E-30
THYM	IUPHAR	MRPL11	SMPD2	0.817362333	1.62E-30
THYM	IUPHAR	MRPL11	TRIM28	0.818612892	1.12E-30
THYM	IUPHAR	MRPL11	ATP6V0B	0.819144586	9.51E-31
THYM	IUPHAR	MRPL11	IMPDH2	0.819823966	7.76E-31
THYM	IUPHAR	MRPL11	HMOX2	0.82100394	5.43E-31
THYM	IUPHAR	MRPL11	MFSD2B	0.828780953	4.83E-32
THYM	IUPHAR	MRPL11	PSMB6	0.829598287	3.72E-32
THYM	IUPHAR	MRPL11	MAP2K2	0.829610976	3.71E-32
THYM	IUPHAR	MRPL11	EGLN2	0.85213218	1.52E-35
THYM	IUPHAR	MRPL11	PSMB1	0.882987401	3.16E-41
THYM	IUPHAR	MRPL11	MVD	0.883661288	2.28E-41
THYM	IUPHAR	MRPL11	SIRT6	0.883877826	2.05E-41
THYM	IUPHAR	MRPL11	PRMT1	0.888844835	1.73E-42
THYM	IUPHAR	MRPL11	SLC27A5	0.90795924	3.76E-47
THYM	Kinase	MRPL11	PHKG2	0.806242841	3.94E-29
THYM	Kinase	MRPL11	TRIM28	0.818612892	1.12E-30
THYM	Kinase	MRPL11	MAP2K2	0.829610976	3.71E-32
THYM	TF	MRPL11	DRAP1	0.806770187	3.40E-29
THYM	TF	MRPL11	ZNF408	0.809983671	1.38E-29
THYM	TF	MRPL11	ZNF511	0.811634907	8.60E-30
THYM	TF	MRPL11	CENPB	0.815787146	2.58E-30
THYM	TF	MRPL11	ZNF444	0.819186872	9.39E-31
THYM	TF	MRPL11	THYN1	0.821140607	5.21E-31
THYM	TF	MRPL11	CXXC1	0.822623725	3.31E-31
THYM	TF	MRPL11	PIN1	0.824853476	1.66E-31
THYM	TF	MRPL11	ZNF688	0.825761197	1.25E-31
THYM	TF	MRPL11	RBCK1	0.827505473	7.25E-32
THYM	TF	MRPL11	ZNF668	0.830143868	3.12E-32
THYM	TF	MRPL11	ZNF32	0.832489346	1.46E-32
THYM	TF	MRPL11	REXO4	0.855229669	4.71E-36
THYM	TF	MRPL11	ZNF581	0.855814741	3.76E-36
THYM	TF	MRPL11	THAP3	0.869392777	1.52E-38
THYM	TF	MRPL11	ZNF787	0.881824286	5.51E-41
THYM	TF	MRPL11	ZNF428	0.885294268	1.03E-41
THYM	TF	MRPL11	MBD3	0.900061858	4.13E-45
THYM	TSG	MRPL11	AIP	0.803210784	9.07E-29
THYM	TSG	MRPL11	STUB1	0.803424881	8.55E-29
THYM	TSG	MRPL11	GABARAP	0.812198229	7.32E-30
THYM	TSG	MRPL11	HTRA2	0.820355219	6.61E-31
THYM	TSG	MRPL11	PIN1	0.824853476	1.66E-31
THYM	TSG	MRPL11	ZNF668	0.830143868	3.12E-32
THYM	TSG	MRPL11	NPRL2	0.835372167	5.65E-33
THYM	TSG	MRPL11	GLTSCR2	0.84295365	4.23E-34
THYM	TSG	MRPL11	GNB2L1	0.854635207	5.91E-36
THYM	TSG	MRPL11	PARK7	0.858841608	1.16E-36
THYM	TSG	MRPL11	GADD45GIP1	0.868159641	2.57E-38
THYM	TSG	MRPL11	PHB	0.875358645	1.10E-39
THYM	TSG	MRPL11	SIRT6	0.883877826	2.05E-41
THYM	TSG	MRPL11	BRMS1	0.905975451	1.27E-46
THYM	TSG	MRPL11	TSSC4	0.92658763	8.46E-53
UCS	Cell metabolism gene	MRPL11	POLR2L	0.800008515	2.16E-28
UCS	Cell metabolism gene	MRPL11	GEMIN6	0.800670496	1.80E-28
UCS	Cell metabolism gene	MRPL11	DOHH	0.800788925	1.75E-28
UCS	Cell metabolism gene	MRPL11	NUDT2	0.80278865	1.02E-28
UCS	Cell metabolism gene	MRPL11	GCDH	0.803300883	8.85E-29
UCS	Cell metabolism gene	MRPL11	SLC25A11	0.806060041	4.14E-29
UCS	Cell metabolism gene	MRPL11	ATP5G1	0.806106042	4.09E-29
UCS	Cell metabolism gene	MRPL11	PHKG2	0.806242841	3.94E-29
UCS	Cell metabolism gene	MRPL11	TIMM17B	0.807016642	3.17E-29
UCS	Cell metabolism gene	MRPL11	PAFAH1B3	0.808665233	2.00E-29
UCS	Cell metabolism gene	MRPL11	NANS	0.809695829	1.49E-29
UCS	Cell metabolism gene	MRPL11	PSMB2	0.80983302	1.44E-29
UCS	Cell metabolism gene	MRPL11	POLR2J	0.81053379	1.18E-29
UCS	Cell metabolism gene	MRPL11	DGUOK	0.810902364	1.06E-29
UCS	Cell metabolism gene	MRPL11	PSMB10	0.81145086	9.07E-30
UCS	Cell metabolism gene	MRPL11	TBCB	0.81217977	7.36E-30
UCS	Cell metabolism gene	MRPL11	HSD17B10	0.812934881	5.92E-30
UCS	Cell metabolism gene	MRPL11	PTGES2	0.813365838	5.22E-30
UCS	Cell metabolism gene	MRPL11	SRM	0.813794704	4.61E-30
UCS	Cell metabolism gene	MRPL11	IDH3G	0.814198696	4.10E-30
UCS	Cell metabolism gene	MRPL11	PIGU	0.814223944	4.07E-30
UCS	Cell metabolism gene	MRPL11	GMPPA	0.81495309	3.29E-30
UCS	Cell metabolism gene	MRPL11	PSMA4	0.816567289	2.05E-30
UCS	Cell metabolism gene	MRPL11	SMPD2	0.817362333	1.62E-30
UCS	Cell metabolism gene	MRPL11	POLA2	0.817616925	1.50E-30
UCS	Cell metabolism gene	MRPL11	GEMIN7	0.818181831	1.27E-30
UCS	Cell metabolism gene	MRPL11	PSMC1	0.818520908	1.15E-30
UCS	Cell metabolism gene	MRPL11	IMPDH2	0.819823966	7.76E-31
UCS	Cell metabolism gene	MRPL11	PSMA5	0.819871764	7.64E-31
UCS	Cell metabolism gene	MRPL11	HMOX2	0.82100394	5.43E-31
UCS	Cell metabolism gene	MRPL11	ALG3	0.821090769	5.29E-31
UCS	Cell metabolism gene	MRPL11	PSMD9	0.822975298	2.97E-31
UCS	Cell metabolism gene	MRPL11	PSMD4	0.824363783	1.94E-31
UCS	Cell metabolism gene	MRPL11	POLR2F	0.824600567	1.80E-31
UCS	Cell metabolism gene	MRPL11	MMAB	0.825060177	1.56E-31
UCS	Cell metabolism gene	MRPL11	PSMD8	0.826993844	8.52E-32
UCS	Cell metabolism gene	MRPL11	POLR3K	0.827658601	6.90E-32
UCS	Cell metabolism gene	MRPL11	NOP56	0.827770712	6.66E-32
UCS	Cell metabolism gene	MRPL11	HMBS	0.828361959	5.52E-32
UCS	Cell metabolism gene	MRPL11	SNRPD3	0.828854964	4.72E-32
UCS	Cell metabolism gene	MRPL11	PSME1	0.829203612	4.22E-32
UCS	Cell metabolism gene	MRPL11	PGP	0.829541547	3.79E-32
UCS	Cell metabolism gene	MRPL11	PSMB6	0.829598287	3.72E-32
UCS	Cell metabolism gene	MRPL11	TOMM22	0.831006446	2.37E-32
UCS	Cell metabolism gene	MRPL11	SEC61G	0.83238341	1.51E-32
UCS	Cell metabolism gene	MRPL11	SNRPE	0.832578823	1.42E-32
UCS	Cell metabolism gene	MRPL11	MTX1	0.832649216	1.39E-32
UCS	Cell metabolism gene	MRPL11	UROS	0.834082327	8.66E-33
UCS	Cell metabolism gene	MRPL11	GALK1	0.834420137	7.74E-33
UCS	Cell metabolism gene	MRPL11	EBP	0.838042209	2.30E-33
UCS	Cell metabolism gene	MRPL11	IDH3B	0.84318578	3.90E-34
UCS	Cell metabolism gene	MRPL11	LCMT1	0.843222962	3.85E-34
UCS	Cell metabolism gene	MRPL11	GUK1	0.843247228	3.82E-34
UCS	Cell metabolism gene	MRPL11	SNRPD1	0.844904171	2.13E-34
UCS	Cell metabolism gene	MRPL11	SNRPB	0.845654027	1.63E-34
UCS	Cell metabolism gene	MRPL11	GFER	0.846708282	1.12E-34
UCS	Cell metabolism gene	MRPL11	POLR2E	0.846789724	1.08E-34
UCS	Cell metabolism gene	MRPL11	TOMM40	0.84702262	9.96E-35
UCS	Cell metabolism gene	MRPL11	EXOSC5	0.84718593	9.39E-35
UCS	Cell metabolism gene	MRPL11	UROD	0.847233874	9.23E-35
UCS	Cell metabolism gene	MRPL11	LSM3	0.849861373	3.54E-35
UCS	Cell metabolism gene	MRPL11	LSM4	0.853645582	8.61E-36
UCS	Cell metabolism gene	MRPL11	MED19	0.855039537	5.06E-36
UCS	Cell metabolism gene	MRPL11	PMPCA	0.85521088	4.74E-36
UCS	Cell metabolism gene	MRPL11	SSR2	0.855909119	3.63E-36
UCS	Cell metabolism gene	MRPL11	PFDN5	0.858505822	1.32E-36
UCS	Cell metabolism gene	MRPL11	FPGS	0.866297565	5.62E-38
UCS	Cell metabolism gene	MRPL11	PSMC5	0.868120317	2.61E-38
UCS	Cell metabolism gene	MRPL11	POLR2I	0.871401931	6.37E-39
UCS	Cell metabolism gene	MRPL11	TIMM10	0.871498635	6.11E-39
UCS	Cell metabolism gene	MRPL11	OAZ1	0.872247712	4.40E-39
UCS	Cell metabolism gene	MRPL11	ITPA	0.874613015	1.54E-39
UCS	Cell metabolism gene	MRPL11	APRT	0.875766193	9.19E-40
UCS	Cell metabolism gene	MRPL11	POLR2H	0.876385618	6.94E-40
UCS	Cell metabolism gene	MRPL11	DTYMK	0.878055551	3.23E-40
UCS	Cell metabolism gene	MRPL11	PGLS	0.880796874	8.98E-41
UCS	Cell metabolism gene	MRPL11	TALDO1	0.881222981	7.34E-41
UCS	Cell metabolism gene	MRPL11	FAU	0.881477496	6.50E-41
UCS	Cell metabolism gene	MRPL11	PSMB1	0.882987401	3.16E-41
UCS	Cell metabolism gene	MRPL11	MVD	0.883661288	2.28E-41
UCS	Cell metabolism gene	MRPL11	DPM2	0.887453578	3.51E-42
UCS	Cell metabolism gene	MRPL11	LSM2	0.889684808	1.13E-42
UCS	Cell metabolism gene	MRPL11	PSMD13	0.894876993	7.34E-44
UCS	Cell metabolism gene	MRPL11	ACOT8	0.90220353	1.20E-45
UCS	Cell metabolism gene	MRPL11	POLD2	0.902538658	9.89E-46
UCS	Cell metabolism gene	MRPL11	TIMM50	0.902824811	8.36E-46
UCS	Cell metabolism gene	MRPL11	PSMB3	0.903862968	4.53E-46
UCS	Cell metabolism gene	MRPL11	EXOSC4	0.903935491	4.34E-46
UCS	Cell metabolism gene	MRPL11	PSMB7	0.906814307	7.63E-47
UCS	Cell metabolism gene	MRPL11	SLC27A5	0.90795924	3.76E-47
UCS	Cell metabolism gene	MRPL11	TIMM8B	0.919059083	2.36E-50
UCS	Cell metabolism gene	MRPL11	PSMC3	0.929464331	8.38E-54
UCS	Cell metabolism gene	MRPL11	SNRPD2	0.934658327	9.95E-56
UCS	Cell metabolism gene	MRPL11	TIMM13	0.946696138	7.05E-61
UCS	CGC	MRPL11	MGMT	0.817615238	1.50E-30
UCS	CGC	MRPL11	MAP2K2	0.829610976	3.71E-32
UCS	CGC	MRPL11	ASPSCR1	0.839291595	1.50E-33
UCS	CGC	MRPL11	RBM10	0.861286861	4.37E-37
UCS	CGC	MRPL11	SDHAF2	0.890319094	8.15E-43
UCS	CGC	MRPL11	TFPT	0.893469032	1.56E-43
UCS	Epifactor	MRPL11	INO80E	0.805919866	4.31E-29
UCS	Epifactor	MRPL11	PPM1G	0.809200706	1.72E-29
UCS	Epifactor	MRPL11	MCRS1	0.814444286	3.82E-30
UCS	Epifactor	MRPL11	TRIM28	0.818612892	1.12E-30
UCS	Epifactor	MRPL11	LAS1L	0.822397111	3.55E-31
UCS	Epifactor	MRPL11	CXXC1	0.822623725	3.31E-31
UCS	Epifactor	MRPL11	PAF1	0.83282143	1.31E-32
UCS	Epifactor	MRPL11	EXOSC5	0.84718593	9.39E-35
UCS	Epifactor	MRPL11	DMAP1	0.850475162	2.82E-35
UCS	Epifactor	MRPL11	RRP8	0.85204498	1.57E-35
UCS	Epifactor	MRPL11	ZNHIT1	0.855073361	5.00E-36
UCS	Epifactor	MRPL11	C17orf49	0.860325875	6.42E-37
UCS	Epifactor	MRPL11	TAF10	0.871539645	6.00E-39
UCS	Epifactor	MRPL11	SIRT6	0.883877826	2.05E-41
UCS	Epifactor	MRPL11	PRMT1	0.888844835	1.73E-42
UCS	Epifactor	MRPL11	RUVBL2	0.891824683	3.72E-43
UCS	Epifactor	MRPL11	PPP4C	0.892084842	3.25E-43
UCS	Epifactor	MRPL11	TFPT	0.893469032	1.56E-43
UCS	Epifactor	MRPL11	NOC2L	0.893889286	1.25E-43
UCS	Epifactor	MRPL11	MBD3	0.900061858	4.13E-45
UCS	Epifactor	MRPL11	EXOSC4	0.903935491	4.34E-46
UCS	Epifactor	MRPL11	BRMS1	0.905975451	1.27E-46
UCS	Epifactor	MRPL11	PRPF31	0.920479847	8.51E-51
UCS	Epifactor	MRPL11	FBL	0.931936944	1.06E-54
UCS	IUPHAR	MRPL11	MPDU1	0.801874689	1.30E-28
UCS	IUPHAR	MRPL11	SLC25A11	0.806060041	4.14E-29
UCS	IUPHAR	MRPL11	PHKG2	0.806242841	3.94E-29
UCS	IUPHAR	MRPL11	PSMB2	0.80983302	1.44E-29
UCS	IUPHAR	MRPL11	MMP24	0.810266455	1.27E-29
UCS	IUPHAR	MRPL11	PPIA	0.810346954	1.24E-29
UCS	IUPHAR	MRPL11	PTGES2	0.813365838	5.22E-30
UCS	IUPHAR	MRPL11	SMPD2	0.817362333	1.62E-30
UCS	IUPHAR	MRPL11	TRIM28	0.818612892	1.12E-30
UCS	IUPHAR	MRPL11	ATP6V0B	0.819144586	9.51E-31
UCS	IUPHAR	MRPL11	IMPDH2	0.819823966	7.76E-31
UCS	IUPHAR	MRPL11	HMOX2	0.82100394	5.43E-31
UCS	IUPHAR	MRPL11	MFSD2B	0.828780953	4.83E-32
UCS	IUPHAR	MRPL11	PSMB6	0.829598287	3.72E-32
UCS	IUPHAR	MRPL11	MAP2K2	0.829610976	3.71E-32
UCS	IUPHAR	MRPL11	EGLN2	0.85213218	1.52E-35
UCS	IUPHAR	MRPL11	PSMB1	0.882987401	3.16E-41
UCS	IUPHAR	MRPL11	MVD	0.883661288	2.28E-41
UCS	IUPHAR	MRPL11	SIRT6	0.883877826	2.05E-41
UCS	IUPHAR	MRPL11	PRMT1	0.888844835	1.73E-42
UCS	IUPHAR	MRPL11	SLC27A5	0.90795924	3.76E-47
UCS	Kinase	MRPL11	PHKG2	0.806242841	3.94E-29
UCS	Kinase	MRPL11	TRIM28	0.818612892	1.12E-30
UCS	Kinase	MRPL11	MAP2K2	0.829610976	3.71E-32
UCS	TF	MRPL11	DRAP1	0.806770187	3.40E-29
UCS	TF	MRPL11	ZNF408	0.809983671	1.38E-29
UCS	TF	MRPL11	ZNF511	0.811634907	8.60E-30
UCS	TF	MRPL11	CENPB	0.815787146	2.58E-30
UCS	TF	MRPL11	ZNF444	0.819186872	9.39E-31
UCS	TF	MRPL11	THYN1	0.821140607	5.21E-31
UCS	TF	MRPL11	CXXC1	0.822623725	3.31E-31
UCS	TF	MRPL11	PIN1	0.824853476	1.66E-31
UCS	TF	MRPL11	ZNF688	0.825761197	1.25E-31
UCS	TF	MRPL11	RBCK1	0.827505473	7.25E-32
UCS	TF	MRPL11	ZNF668	0.830143868	3.12E-32
UCS	TF	MRPL11	ZNF32	0.832489346	1.46E-32
UCS	TF	MRPL11	REXO4	0.855229669	4.71E-36
UCS	TF	MRPL11	ZNF581	0.855814741	3.76E-36
UCS	TF	MRPL11	THAP3	0.869392777	1.52E-38
UCS	TF	MRPL11	ZNF787	0.881824286	5.51E-41
UCS	TF	MRPL11	ZNF428	0.885294268	1.03E-41
UCS	TF	MRPL11	MBD3	0.900061858	4.13E-45
UCS	TSG	MRPL11	AIP	0.803210784	9.07E-29
UCS	TSG	MRPL11	STUB1	0.803424881	8.55E-29
UCS	TSG	MRPL11	GABARAP	0.812198229	7.32E-30
UCS	TSG	MRPL11	HTRA2	0.820355219	6.61E-31
UCS	TSG	MRPL11	PIN1	0.824853476	1.66E-31
UCS	TSG	MRPL11	ZNF668	0.830143868	3.12E-32
UCS	TSG	MRPL11	NPRL2	0.835372167	5.65E-33
UCS	TSG	MRPL11	GLTSCR2	0.84295365	4.23E-34
UCS	TSG	MRPL11	GNB2L1	0.854635207	5.91E-36
UCS	TSG	MRPL11	PARK7	0.858841608	1.16E-36
UCS	TSG	MRPL11	GADD45GIP1	0.868159641	2.57E-38
UCS	TSG	MRPL11	PHB	0.875358645	1.10E-39
UCS	TSG	MRPL11	SIRT6	0.883877826	2.05E-41
UCS	TSG	MRPL11	BRMS1	0.905975451	1.27E-46
UCS	TSG	MRPL11	TSSC4	0.92658763	8.46E-53
UVM	Cell metabolism gene	MRPL11	TOMM22	0.809861337	9.44E-20
UVM	Cell metabolism gene	MRPL11	SSR2	0.826091524	4.04E-21
UVM	Cell metabolism gene	MRPL11	MPST	0.857782857	2.99E-24
UVM	Cell metabolism gene	MRPL11	FAU	0.865031154	4.48E-25
UVM	CGC	MRPL11	TRAF7	0.82020984	1.31E-20
UVM	Epifactor	MRPL11	TRIM28	0.817670806	2.16E-20
UVM	Epifactor	MRPL11	FBL	0.821576749	1.00E-20
UVM	IUPHAR	MRPL11	TRIM28	0.817670806	2.16E-20
UVM	IUPHAR	MRPL11	MPST	0.857782857	2.99E-24
UVM	Kinase	MRPL11	TRIM28	0.817670806	2.16E-20
UVM	TF	MRPL11	ZNF581	0.861689815	1.09E-24

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KICH	MRPL11	MRPL9	1.16888038960038	0.000120222568511963
LUAD	MRPL11	MRPL1	-4.10244425554298	0.000208420954456934
STAD	MRPL11	MRPL15	-2.15546608137429	0.000334546435624361
LIHC	MRPL11	MRPL13	1.54402472107614	0.000655351190157038
COAD	MRPL11	MRPL41	-2.99561502382389	0.00144392251968384
BLCA	MRPL11	MRPL27	-4.19270554058168	0.00202178955078125
CHOL	MRPL11	MRPL2	-1.49926301466752	0.00390625
CHOL	MRPL11	MRPL3	-2.68429255990621	0.00390625
CHOL	MRPL11	MRPL41	-4.96379377542225	0.00390625
ESCA	MRPL11	MRPL3	-4.97897094908275	0.0048828125
THCA	MRPL11	MRPL41	-3.88188543554269	0.00492925389458784
COAD	MRPL11	MRPL15	1.17181689924568	0.00513318181037904
ESCA	MRPL11	MRPL13	-1.07746088474995	0.0068359375
STAD	MRPL11	MRPL9	-1.54523483458273	0.0118026207201183
STAD	MRPL11	MRPL4	1.4393539135682	0.0279771662317216
BLCA	MRPL11	MRPL2	-3.29210657477178	0.0445594787597656
UCEC	MRPL11	MRPL1	1.6396358493858	0.046875
LIHC	MRPL11	MRPL1	-1.02017251293973	0.0489222263070731
LUAD	MRPL11	MRPL2	-1.26727646741024	1.07341296213058e-06
BRCA	MRPL11	MRPL27	-1.5584165725499	1.16393956539382e-08
KICH	MRPL11	MRPL15	1.54522142310359	1.19209289550781e-07
LUSC	MRPL11	MRPL15	-4.43702988385305	1.91594862886626e-08
KIRC	MRPL11	MRPL3	1.69955762234244	1.97132191719422e-08
KIRC	MRPL11	MRPL1	-2.41150752999954	2.48522755147716e-09
COAD	MRPL11	MRPL4	2.77705897514473	2.98023223876954e-07
LUAD	MRPL11	MRPL27	-1.39404329671842	3.44055922076328e-05
LUSC	MRPL11	MRPL27	-1.81809468729316	3.90393047420304e-06
PRAD	MRPL11	MRPL41	1.31179686307216	4.41809300064344e-05
BRCA	MRPL11	MRPL15	-3.82448964360727	5.49451113259074e-14
LUSC	MRPL11	MRPL2	-2.66710222706783	7.24218086307245e-08
KICH	MRPL11	MRPL41	1.05103651319563	7.49826431274414e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MRPL11

ICT1, HTT, CUL3, CUL1, COPS5, CAND1, APP, MRPL16, MRPL15, MRPL39, MRPL13, MRPL2, MRPL12, MRPL40, MRPL32, MRPL1, MRPL10, MRPL9, MRPL38, MRPL19, MRPL45, TUFM, SAMM50, MPV17, ILF3, TMEM177, SSBP1, FKBP8, DLD, ERGIC1, GADD45GIP1, DDX28, gag, NPM1, GRSF1, CAMK2B, CAMK2D, CRYAB, VPS52, TFCP2, TAX1BP1, PNMA1, JAKMIP2, THAP1, HOMEZ, HMBOX1, FSD2, KRT40, SLC16A9, MOV10, RNF2, MRPL4, MRPL37, MRPS30, MRPL47, HNRNPA1, RPS5, NDUFAB1, POLR3A, ORC1, ANAPC15, Cep131, Prkci, Trp53bp1, Mad2l1bp, Tnpo1, ZNF746, MRPL42, MRPL50, MRPL41, RPS8, CYLD, CFTR, CDC26, HUS1, MBTPS2, METTL17, MRPS10, PRMT5, TOMM22, WDR5, TRIP4, EFTUD2, LARP7, MTUS2, RIOK1, ESR2, HEXIM1, RECQL4, REST, RPS6, TGOLN2, MRM1, COX14, TRMT61B, AURKAIP1, RC3H1, RC3H2, PHB, ALYREF, SNRNP70, NFX1, TRIM28, LRRK2, CAMK2A, TFIP11, STX2, PDCL, CAMK2G, JAKMIP1, ZBTB8A, ZNF526, AGTRAP, ZBTB2, CCDC172, MRPL54, ZNF438, GOLGA6L9, ZBTB14, PLEKHA4, ZC3H18, RASA1, HIST1H2BH, ERCC6, SMG7, ARHGAP20, MDH2, ABCB7, ACAD9, ACAT1, ACOT1, ACOT2, AFG3L2, ALAS1, ANGEL2, ATP5B, ATP5D, ATP5J2-PTCD1, ATP5F1, ATP5H, ATP5J, ATP5O, ATPAF1, BCS1L, C17orf80, CARS2, CDK5RAP1, CENPV, CLPP, CLPX, CMAS, COX5A, CS, DAP3, DBT, DDX50, DDX54, DHTKD1, DHX30, DLAT, DLST, EARS2, EBNA1BP2, ECHS1, ECI2, ECSIT, ELAC2, ERAL1, ETFA, ETFB, FASTKD2, FECH, GARS, GATB, GFM1, GLS, GLUD1, GTPBP10, GTPBP6, GUF1, HADH, HADHA, HARS2, HINT2, HMGA1, HNRNPAB, HNRNPDL, HNRNPL, HNRNPUL1, HSPE1, IARS2, IBA57, KIAA0391, LARS2, LETM1, LRP2, LRPPRC, LUC7L, LYRM4, LYRM7, ME2, MGME1, MMAB, RNMTL1, MRPL14, MRPL17, MRPL18, MRPL20, MRPL21, MRPL22, MRPL23, MRPL24, MRPL27, MRPL28, MRPL3, MRPL30, MRPL43, MRPL44, MRPL46, MRPL48, MRPL49, MRPL51, MRPL52, MRPL53, MRPL55, MRPS11, MRPS14, MRPS15, MRPS16, MRPS17, MRPS18A, MRPS18B, MRPS18C, MRPS2, MRPS22, MRPS23, MRPS24, MRPS25, MRPS26, MRPS27, MRPS28, MRPS31, MRPS33, MRPS34, MRPS35, MRPS36, MRPS5, MRPS6, MRPS7, MRPS9, MTERF3, MTIF2, MTPAP, NDUFA12, NDUFA2, NDUFA5, NDUFA6, NDUFA7, NDUFA9, NDUFAF1, NDUFAF2, NDUFAF3, NDUFAF4, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, NFS1, NGRN, NIPSNAP1, NME4, NNT, NOA1, NT5DC2, NUDT19, OGDH, PAM16, PDE12, PDHA1, PDHB, PDHX, PDK3, PDPR, PHB2, PNPT1, POLDIP2, POLG, POLRMT, PPIF, PREPL, PTCD3, PYCR1, PYCR2, QRSL1, RBFA, RBMX, WBSCR16, RPS27A, RPUSD4, RRS1, RTN4IP1, SHMT2, SLC30A9, SLIRP, STOML2, SUCLA2, SUPV3L1, TACO1, TEFM, THEM4, THG1L, TIMM44, TRMT10C, TRUB2, C10orf2, UQCC1, VARS2, VWA8, MTG1, MTG2, nsp8ab, ORF4a, INS, MAFB, PTEN, RBM39, UFL1, DDRGK1, MAP4K2, MAP4K3, SRSF4, RPL13A, RPL37, RPL6, RPL19, YBX1, SRSF3, PAIP2B, MALSU1, RPL27A, RPL13, YBX2, RBMS2, H1FNT, CSRP3, RPL35, RPL10, ABT1, ZC3H3, LIN28A, BTF3, FBXW7, TMPRSS2, TOP3B, CTSL, IFITM1, DPP4, IFITM3, TMPRSS11B, CLEC4D, CLEC4E, CCNF, ELF1, ETV3, ETV4, KLF12, KLF6, KLF9, LHX1, LHX2, LHX4, SOX15, SOX17, SOX2, SP7, TLX3,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MRPL11	KIRP	chr11	66204727	66204727	C	G	Missense_Mutation	p.E107D	3
MRPL11	UCEC	chr11	66204588	66204588	G	A	Missense_Mutation	p.R154C	3
MRPL11	BRCA	chr11	66204842	66204842	C	G	Missense_Mutation	p.E98Q	3
MRPL11	UCS	chr11	66204693	66204693	C	T	Missense_Mutation	p.E119K	3
MRPL11	ESCA	chr11	66204663	66204663	C	T	Missense_Mutation	p.A129T	3
MRPL11	LIHC	chr11	66206166	66206166	G	T	Silent	p.I20I	3
MRPL11	BLCA	chr11	66206132	66206132	C	G	Missense_Mutation	p.G32R	2
MRPL11	BRCA	chr11	66203553	66203553	C	T	Silent	p.Q168	2
MRPL11	CHOL	chr11	66203493	66203493	T	G	Missense_Mutation		2
MRPL11	CHOL	chr11	66203493	66203493	T	G	Missense_Mutation	p.E188D	2
MRPL11	SARC	chr11	66204881	66204881	G	T	Missense_Mutation		2
MRPL11	LIHC	chr11	66204833	66204833	C	-	Frame_Shift_Del	p.A101fs	2
MRPL11	SKCM	chr11	66204871	66204871	G	A	Missense_Mutation	p.S88F	2
MRPL11	BLCA	chr11	66204693	66204693	C	G	Missense_Mutation		2
MRPL11	SKCM	chr11	66204342	66204342	G	A	Missense_Mutation	p.S171F	2
MRPL11	ESCA	chr11	66204686	66204686	G	T	Missense_Mutation	p.A121D	2
MRPL11	ESCA	chr11	66203571	66203571	T	C	Silent	p.E162E	1
MRPL11	LIHC	chr11	66206210	66206210	G	-	Frame_Shift_Del	p.R6fs	1
MRPL11	BLCA	chr11	66204693	66204693	C	G	Missense_Mutation	p.E119Q	1
MRPL11	SKCM	chr11	66204635	66204635	G	A	Missense_Mutation	p.S138L	1
MRPL11	GBM	chr11	66204907	66204907	C	A	Missense_Mutation		1
MRPL11	LIHC	chr11	66206197	66206197	C	-	Frame_Shift_Del	p.G10fs	1
MRPL11	SKCM	chr11	66206157	66206157	G	A	Silent	p.I23I	1
MRPL11	LUAD	chr11	66204347	66204347	C	A	Missense_Mutation	p.K169N	1
MRPL11	KIRP	chr11	66204727	66204727	C	G	Missense_Mutation		1
MRPL11	LUAD	chr11	66206175	66206175	G	A	Silent	p.G17G	1
MRPL11	KIRP	chr11	66206200	66206200	C	A	Missense_Mutation		1
MRPL11	LUAD	chr11	66204683	66204683	C	T	Missense_Mutation	p.R122H	1
MRPL11	LGG	chr11	66204828	66204828	C	A	Silent	p.R102R	1
MRPL11	LUSC	chr11	66206131	66206131	C	A	Missense_Mutation	p.G32V	1
MRPL11	LIHC	chr11	66206166	66206166	G	T	Silent		1
MRPL11	PRAD	chr11	66203543	66203543	C	T	Missense_Mutation	p.A172T	1
MRPL11	COAD	chr11	66203567	66203567	G	C	Missense_Mutation	p.L164V	1
MRPL11	LIHC	chr11	66204833	66204833	C	-	Frame_Shift_Del		1
MRPL11	COAD	chr11	66204700	66204700	A	G	Silent	p.H116H	1
MRPL11	LIHC	chr11	66205721	66205721	A	-	Frame_Shift_Del	p.S45fs	1
MRPL11	BLCA	chr11	66206132	66206132	C	G	Missense_Mutation		1
MRPL11	SKCM	chr11	66204361	66204361	G	A	Silent	p.L165L	1

Copy number variation (CNV) of MRPL11
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MRPL11
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
88554	N/A	BF344884	MRPL11	chr11	66203308	-	CDH10	chr5	24575451	+
93821	N/A	AF090922	MRPL11	chr11	66206312	+	MRFAP1	chr4	6643927	+
87049	BRCA	TCGA-B6-A0I2-01A	MRPL11	chr11	66204575	-	ST8SIA1	chr12	22402032	-
61785	STAD	TCGA-BR-8078-01A	NDUFA12	chr12	95396582	-	MRPL11	chr11	66205730	-
61797	CESC	TCGA-RA-A741-01A	OSBPL1A	chr18	21851586	-	MRPL11	chr11	66205730	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
THYM	MRPL11	0.0248347137132006	0.67
HNSC	MRPL11	2.72852611978312e-05	0.00076

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	MRPL11	0.0210441100218838	0.57
LUSC	MRPL11	0.0197961755919106	0.55
THCA	MRPL11	0.00224719921663175	0.072
LGG	MRPL11	0.000344675866108181	0.011
BRCA	MRPL11	0.0101059898851306	0.29
PRAD	MRPL11	0.00758047357341896	0.23
PAAD	MRPL11	0.00745438112015729	0.23
SARC	MRPL11	0.0436182915018983	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source