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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MRPL44 (NCBI Gene ID:65080)

Gene Summary

Gene Summary

Gene Information	Gene Name: MRPL44
	Gene ID: 65080
	Gene Symbol	MRPL44
	Gene ID	65080
	Gene Name	mitochondrial ribosomal protein L44
	Synonyms	COXPD16\|L44MT\|MRP-L44
	Cytomap	2q36.1
	Type of Gene	protein-coding
	Description	39S ribosomal protein L44, mitochondrialmitochondrial large ribosomal subunit protein mL44
	Modification date	20200313
	UniProtAcc	Q9H9J2

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0032543	Mitochondrial translation
GO:0005840	Ribosome
GO:0006414	Translational elongation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MRPL44	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'MRPL44[title] AND translation [title] AND human.'

Gene	Title	PMID
MRPL44	Pathogenic variants in MRPL44 cause infantile cardiomyopathy due to a mitochondrial translation defect	34140213

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUSC	MRPL44	-1.0353261138043	0.000533204507372277
CHOL	MRPL44	-1.84100898736725	0.01171875
BRCA	MRPL44	-2.66444869593332	3.06751315169682e-08
LUAD	MRPL44	-3.23791370825974	5.91982739853218e-07

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
PCPG	MRPL44	0.132452783	0.004089622

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MRPL44 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
GBM	Cell metabolism gene	MRPL44	PFDN5	0.806983237	9.88E-41
GBM	Cell metabolism gene	MRPL44	PSMA6	0.808208986	6.08E-41
GBM	Cell metabolism gene	MRPL44	NME1	0.809410537	3.76E-41
GBM	Cell metabolism gene	MRPL44	CCT4	0.816448773	2.12E-42
GBM	Cell metabolism gene	MRPL44	SUCLG1	0.882803109	1.14E-57
GBM	TSG	MRPL44	NME1	0.809410537	3.76E-41
KICH	Cell metabolism gene	MRPL44	SUCLG1	0.810573311	2.16E-22
KICH	Cell metabolism gene	MRPL44	ADI1	0.819966148	2.79E-23
KICH	Cell metabolism gene	MRPL44	SDHC	0.820282942	2.60E-23
KICH	CGC	MRPL44	SDHC	0.820282942	2.60E-23

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
BRCA	MRPL44	MRPL32	-3.7979134181794	0.000134327661287861
STAD	MRPL44	MRPL15	-2.15546608137429	0.000334546435624361
LIHC	MRPL44	MRPL13	1.54402472107614	0.000655351190157038
LUSC	MRPL44	MRPL39	-3.50411737429004	0.000985010025625636
KIRC	MRPL44	MRPL46	-7.36081421944909	0.0011460554764592
LUAD	MRPL44	MRPL32	-2.1966239418264	0.00121089428940613
KIRP	MRPL44	MRPL46	-7.17671685013906	0.00123529229313135
KIRP	MRPL44	MRPL19	-1.9689242575519	0.00179363833740354
ESCA	MRPL44	MRPL47	-2.26373711796715	0.001953125
CHOL	MRPL44	MRPL46	-2.73791743817321	0.00390625
BLCA	MRPL44	MRPL39	1.69896851960452	0.00391769409179688
LUAD	MRPL44	MRPL39	-1.1049452981592	0.00471395891927286
COAD	MRPL44	MRPL15	1.17181689924568	0.00513318181037904
KICH	MRPL44	MRPL19	-2.18550705564541	0.00672554969787598
ESCA	MRPL44	MRPL13	-1.07746088474995	0.0068359375
COAD	MRPL44	MRPL47	-2.29582381838246	0.00863465666770936
KICH	MRPL44	MRPL43	-2.18179102009894	0.00963503122329712
STAD	MRPL44	MRPL47	-1.4008685687155	0.0118026207201183
STAD	MRPL44	MRPL4	1.4393539135682	0.0279771662317216
COAD	MRPL44	MRPL39	-1.15285953291756	0.0357243716716767
KIRC	MRPL44	MRPL32	-2.79664327578899	0.0376051795400881
CHOL	MRPL44	MRPL19	-2.09295650388558	0.0390625
LIHC	MRPL44	MRPL47	-6.59586850948538	0.0416658979324166
KIRC	MRPL44	MRPL47	1.74758475364701	1.00533732476669e-06
KICH	MRPL44	MRPL15	1.54522142310359	1.19209289550781e-07
LUSC	MRPL44	MRPL15	-4.43702988385305	1.91594862886626e-08
LIHC	MRPL44	MRPL32	-1.20074144698753	2.24402029682138e-06
COAD	MRPL44	MRPL4	2.77705897514473	2.98023223876954e-07
LIHC	MRPL44	MRPL39	-1.65461683386216	3.95799979560965e-08
BRCA	MRPL44	MRPL15	-3.82448964360727	5.49451113259074e-14
LUAD	MRPL44	MRPL47	-1.74990909879567	9.53955602455483e-07

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MRPL44

NFKBIL1, ARRB2, IMMT, SETDB1, VIM, ICT1, MME, SHC1, CEP70, ITFG1, PI4KA, SEMA5B, USP22, PTN, NGEF, ZNF235, TCF3, CUL3, MRPL24, MRPL9, MRPL39, MRPL38, MRPL37, MRPL32, MRPL19, MRPL41, MRPL51, MRPL47, MRPL50, MRPL42, MRPL13, TMEM177, ILF3, TSR1, ATP6V0A1, HNRNPU, SPCS2, MPV17, SYNJ2BP, EIF4H, C1QBP, NPM1, DGKE, PPAP2C, TARDBP, ABI2, BTRC, MRPL43, MRPL28, RPS8, MRPL4, HNRNPA1, CASQ2, MRPS30, NTRK1, NDUFA11, ILK, KIF15, GBA2, MRPL1, DUSP11, MRPL10, MRPL12, TNFRSF13B, CYLD, TNIP2, LARP7, MEPCE, RECQL4, MRM1, HSPD1, PDK1, TRMT61B, AURKAIP1, TP63, PHB, MTDH, SNRNP70, BIRC3, PLEKHA4, RASA1, GRSF1, KIF14, ACAD9, AUH, C12orf65, C17orf80, C21orf33, C6orf203, C8orf82, MCUR1, CHCHD1, COX15, CS, DDX28, DHX30, EXD2, FASTKD2, FASTKD3, FASTKD5, GFM1, GFM2, HINT2, LONP1, LRPPRC, CCDC109B, MDH2, METTL15, METTL17, MRPL11, MRPS12, MRPS26, MRRF, MTERF3, MTFMT, MTG1, MTG2, MTIF2, MTIF3, MTRF1, MTRF1L, NGRN, PMPCA, PMPCB, RMND1, RPUSD3, RPUSD4, SLC25A51, SLIRP, SSBP1, SURF1, TACO1, TBRG4, TEFM, TFAM, C19orf52, TMEM70, TRUB2, TSFM, TUFM, VWA8, CLPP, Apc2, DNAJA3, DNAJC15, DNAJC19, DNAJC28, DNAJC9, HSCB, HSPA9, MRPL27, MRPL15, MRPL18, TRA2A, SRSF10, HIST1H1T, MRPL49, MRPL20, MRPL17, MRPL45, RNPS1, MRPL23, MRPS18A, MRPL21, DIEXF, CFAP20, SRSF9, AARS2, COX4I1, COX8A, PDHA1, TRAP1, MRPL2, RPL27A, SRSF5, MRPL30, MRPL52, RPL17, YBX2, MRPS17, H1FNT, MRPL53, ZNF485, PTCD1, MRPL35, RPL37, RPL19, RBMS2, YBX1, MALSU1, FAM120A, RPL13A, RBMS3, RPL10, MRPL46, GADD45GIP1, PRR3, RBM47, SRSF7, RBPMS, DMRTB1, KRT31, PRPF6, QKI, PRRC2B, Taf15, KLF15,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
MRPL44	chr2	224821790	A	T	single_nucleotide_variant	Benign	not_provided	SO:0002153\|genic_upstream_transcript_variant	SO:0002153\|genic_upstream_transcript_variant
MRPL44	chr2	224821984	T	G	single_nucleotide_variant	Benign	not_provided	SO:0002153\|genic_upstream_transcript_variant	SO:0002153\|genic_upstream_transcript_variant
MRPL44	chr2	224822040	C	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0002153\|genic_upstream_transcript_variant	SO:0002153\|genic_upstream_transcript_variant
MRPL44	chr2	224822043	C	G	single_nucleotide_variant	Benign	not_provided	SO:0002153\|genic_upstream_transcript_variant	SO:0002153\|genic_upstream_transcript_variant
MRPL44	chr2	224822106	G	T	single_nucleotide_variant	Benign	not_provided	SO:0002153\|genic_upstream_transcript_variant	SO:0002153\|genic_upstream_transcript_variant
MRPL44	chr2	224822219	G	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MRPL44	chr2	224822227	A	G	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	not_specified\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPL44	chr2	224822229	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPL44	chr2	224822377	C	T	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL44	chr2	224822574	C	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL44	chr2	224822669	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL44	chr2	224824002	C	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL44	chr2	224824263	G	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MRPL44	chr2	224824315	A	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPL44	chr2	224824384	C	T	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	not_specified\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPL44	chr2	224824484	C	T	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPL44	chr2	224824528	A	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPL44	chr2	224824538	T	C	single_nucleotide_variant	Pathogenic	Combined_oxidative_phosphorylation_deficiency_16	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPL44	chr2	224824538	T	G	single_nucleotide_variant	Likely_pathogenic	Combined_oxidative_phosphorylation_deficiency_16\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPL44	chr2	224824552	ACTG	TC	Indel	Pathogenic	Combined_oxidative_phosphorylation_deficiency_16	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
MRPL44	chr2	224824567	G	A	single_nucleotide_variant	not_provided	Combined_oxidative_phosphorylation_deficiency_16	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPL44	chr2	224824576	G	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPL44	chr2	224824617	A	G	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MRPL44	chr2	224824655	T	C	single_nucleotide_variant	not_provided	Mitochondrial_complex_IV_deficiency	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPL44	chr2	224824695	T	C	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MRPL44	chr2	224824723	C	T	single_nucleotide_variant	Benign/Likely_benign	not_specified\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL44	chr2	224824735	T	C	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL44	chr2	224824884	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL44	chr2	224824890	T	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL44	chr2	224828168	G	GA	Duplication	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL44	chr2	224828298	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL44	chr2	224828496	T	A	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MRPL44	chr2	224828570	A	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPL44	chr2	224828615	C	G	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_16	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPL44	chr2	224828616	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MRPL44	chr2	224828624	T	A	single_nucleotide_variant	Pathogenic	Combined_oxidative_phosphorylation_deficiency_1	SO:0001587\|nonsense	SO:0001587\|nonsense
MRPL44	chr2	224828625	G	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MRPL44	chr2	224828669	C	T	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL44	chr2	224828861	T	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL44	chr2	224831567	G	C	single_nucleotide_variant	Benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPL44	chr2	224831634	A	G	single_nucleotide_variant	Likely_benign	not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MRPL44	chr2	224831637	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MRPL44	chr2	224831640	T	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MRPL44	chr2	224831706	G	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MRPL44	chr2	224831753	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
MRPL44	chr2	224831832	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MRPL44	SARC	chr2	224824624	224824624	C	T	Missense_Mutation	p.P185S	5
MRPL44	UCEC	chr2	224824263	224824263	G	A	Silent	p.P64	4
MRPL44	KIRP	chr2	224824513	224824513	A	G	Missense_Mutation	p.M148V	4
MRPL44	UCS	chr2	224822309	224822309	C	A	Silent	p.R40R	3
MRPL44	UCS	chr2	224831613	224831613	A	G	Silent	p.E287E	3
MRPL44	SKCM	chr2	224824592	224824592	C	T	Missense_Mutation	p.A174V	3
MRPL44	SARC	chr2	224824624	224824624	C	T	Missense_Mutation		2
MRPL44	SARC	chr2	224824683	224824683	G	T	Missense_Mutation		2
MRPL44	LUAD	chr2	224828609	224828609	G	A	Missense_Mutation	p.G262D	2
MRPL44	SARC	chr2	224831683	224831683	A	G	Missense_Mutation		2
MRPL44	STAD	chr2	224828559	224828559	G	-	Frame_Shift_Del	p.L245fs	2
MRPL44	LUAD	chr2	224822340	224822340	C	T	Silent	p.L51L	2
MRPL44	TGCT	chr2	224824617	224824617	A	G	Silent		2
MRPL44	CHOL	chr2	224828637	224828637	T	G	Missense_Mutation		2
MRPL44	SARC	chr2	224831683	224831683	A	G	Missense_Mutation	p.R311G	2
MRPL44	CHOL	chr2	224828637	224828637	T	G	Missense_Mutation	p.F271L	2
MRPL44	UCEC	chr2	224828559	224828559	G	A	Silent	p.L245	2
MRPL44	SKCM	chr2	224828523	224828523	G	C	Missense_Mutation	p.K233N	2
MRPL44	UCEC	chr2	224828614	224828614	A	G	Missense_Mutation	p.T264A	2
MRPL44	SKCM	chr2	224822295	224822295	C	T	Missense_Mutation	p.R36C	2
MRPL44	BLCA	chr2	224824694	224824694	C	A	Missense_Mutation	p.P208H	2
MRPL44	SKCM	chr2	224828523	224828523	G	A	Silent	p.K233K	2
MRPL44	LIHC	chr2	224824366	224824366	A	-	Frame_Shift_Del	p.K99fs	2
MRPL44	BLCA	chr2	224822290	224822290	G	A	Missense_Mutation		1
MRPL44	LIHC	chr2	224824530	224824530	A	-	Frame_Shift_Del	p.I153fs	1
MRPL44	CESC	chr2	224824505	224824508	ACCC	-	Frame_Shift_Del		1
MRPL44	HNSC	chr2	224824585	224824585	A	G	Missense_Mutation		1
MRPL44	SKCM	chr2	224824666	224824666	A	T	Missense_Mutation	p.I199F	1
MRPL44	BLCA	chr2	224831686	224831686	C	T	Missense_Mutation		1
MRPL44	LIHC	chr2	224824283	224824283	A	-	Frame_Shift_Del	p.E71fs	1
MRPL44	CESC	chr2	224824575	224824575	C	T	Silent		1
MRPL44	HNSC	chr2	224831662	224831662	C	G	Missense_Mutation		1
MRPL44	STAD	chr2	224828559	224828559	G	-	Frame_Shift_Del		1
MRPL44	BLCA	chr2	224824315	224824315	A	G	Missense_Mutation		1
MRPL44	CESC	chr2	224824505	224824508	ACCC	-	Frame_Shift_Del	p.Y145fs	1
MRPL44	HNSC	chr2	224824585	224824585	A	G	Missense_Mutation	p.N172D	1
MRPL44	BLCA	chr2	224822184	224822184	C	T	Missense_Mutation		1
MRPL44	CESC	chr2	224824575	224824575	C	T	Silent	p.H168	1
MRPL44	SARC	chr2	224824449	224824449	C	A	Silent		1
MRPL44	HNSC	chr2	224824372	224824372	G	A	Missense_Mutation	p.E101K	1
MRPL44	BLCA	chr2	224824694	224824694	C	A	Missense_Mutation		1
MRPL44	LUAD	chr2	224822353	224822353	C	G	Missense_Mutation	p.P55R	1
MRPL44	HNSC	chr2	224831662	224831662	C	G	Missense_Mutation	p.L304V	1
MRPL44	UCS	chr2	224831613	224831613	A	G	Silent		1
MRPL44	BLCA	chr2	224824558	224824558	G	A	Missense_Mutation		1
MRPL44	LUAD	chr2	224831597	224831597	C	T	Missense_Mutation	p.A282V	1
MRPL44	KIRP	chr2	224824598	224824598	A	G	Missense_Mutation	p.E176G	1
MRPL44	BLCA	chr2	224824491	224824506	TCTTGAAGACGAGTAC	-	Frame_Shift_Del		1
MRPL44	LUSC	chr2	224822335	224822335	G	T	Missense_Mutation	p.R49L	1
MRPL44	COAD	chr2	224824355	224824355	G	A	Missense_Mutation	p.S95N	1
MRPL44	BLCA	chr2	224822290	224822290	G	A	Missense_Mutation	p.G34E	1
MRPL44	LUSC	chr2	224824686	224824686	C	T	Silent	p.S205S	1
MRPL44	COAD	chr2	224824384	224824384	C	T	Missense_Mutation	p.R105C	1
MRPL44	KIRP	chr2	224824513	224824513	A	G	Missense_Mutation		1
MRPL44	UCS	chr2	224822309	224822309	C	A	Silent		1
MRPL44	BLCA	chr2	224824315	224824315	A	G	Missense_Mutation	p.N82D	1
MRPL44	OV	chr2	224532732	224532732	G	C	Missense_Mutation	p.Q139H	1
MRPL44	COAD	chr2	224824617	224824617	A	G	Silent	p.E182E	1
MRPL44	LIHC	chr2	224824697	224824697	A	G	Missense_Mutation	p.E209G	1
MRPL44	PRAD	chr2	224828620	224828620	G	T	Missense_Mutation	p.A266S	1
MRPL44	COAD	chr2	224824385	224824385	G	A	Missense_Mutation	p.R105H	1
MRPL44	BLCA	chr2	224824558	224824558	G	A	Missense_Mutation	p.E163K	1
MRPL44	READ	chr2	224824613	224824613	G	A	Missense_Mutation	p.S181N	1
MRPL44	HNSC	chr2	224824372	224824372	G	A	Missense_Mutation		1
MRPL44	SKCM	chr2	224822312	224822312	C	T	Silent	p.F41F	1

Copy number variation (CNV) of MRPL44
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MRPL44
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
96109	PRAD	TCGA-WW-A8ZI-01A	MRPL44	chr2	224824719	-	ABCG1	chr21	43645781	+
99563	N/A	FN079048	MRPL44	chr2	224831901	+	DGKH	chr13	42729570	+
80891	OV	TCGA-30-1861	SETD2	chr3	47205343	-	MRPL44	chr2	224824250	+
80891	OV	TCGA-30-1861-01A	SETD2	chr3	47205344	-	MRPL44	chr2	224824251	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	MRPL44	0.00098135988825616	0.027
LUAD	MRPL44	0.00576471624622125	0.16
MESO	MRPL44	0.0296438731541987	0.77
ACC	MRPL44	0.0395449454871966	0.99

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	MRPL44	0.0153635841195684	0.51
LGG	MRPL44	0.0284545272499172	0.88
OV	MRPL44	0.036339355208016	1
THYM	MRPL44	0.0244559025571457	0.78

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C3809339	COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 16	1	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT