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Translation Factor: JMJD4 (NCBI Gene ID:65094) |
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Gene Summary |
Gene Information | Gene Name: JMJD4 | Gene ID: 65094 | Gene Symbol | JMJD4 | Gene ID | 65094 |
Gene Name | jumonji domain containing 4 | |
Synonyms | - | |
Cytomap | 1q42.13 | |
Type of Gene | protein-coding | |
Description | 2-oxoglutarate and iron-dependent oxygenase JMJD42-oxoglutarate- and Fe(II)-dependent oxygenaseC4 lysyl hydroxylasejmjC domain-containing protein 4jumonji domain-containing protein 4lysyl-hydroxylase JMJD4 | |
Modification date | 20200313 | |
UniProtAcc | Q9H9V9 |
Child GO biological process term(s) under GO:0006412 |
GO ID | GO term |
GO:0006417 | Regulation of translation |
GO:0006415 | Translational termination |
GO:0045727 | Positive regulation of translation |
GO:0006412 | Translation |
Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Inferred gene age of translation factor. |
Gene | Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25 |
JMJD4 | >1119.25 |
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We searched PubMed using 'JMJD4[title] AND translation [title] AND human.' |
Gene | Title | PMID |
JMJD4 | . | . |
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Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. For more annotations, please visit our ExonSkipDB. |
Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ENST | Exon skip start (DNA) | Exon Skip end (DNA) | ORF |
ENST00000366758 | 227920581 | 227920728 | In-frame |
ENST00000366758 | 227921114 | 227921382 | Frame-shift |
ENST00000366758 | 227921607 | 227921733 | In-frame |
ENST00000366758 | 227922351 | 227922517 | Frame-shift |
Exon skipping position in the amino acid sequence. |
ENST | Exon skip start (DNA) | Exon Skip end (DNA) | Len(transcript seq) | Exon skip start (mRNA) | Exon Skip end (mRNA) | Len(amino acid seq) | Exon skip start (AA) | Exon Skip end (AA) |
ENST00000366758 | 227920581 | 227920728 | 2612 | 961 | 1107 | 463 | 320 | 369 |
ENST00000366758 | 227921607 | 227921733 | 2612 | 567 | 692 | 463 | 189 | 230 |
Potentially (partially) lost protein functional features of UniProt. |
UniProtAcc | Exon skip start (AA) | Exon Skip end (AA) | Function feature start (AA) | Function feature end (AA) | Functional feature type | Functional feature desc. |
Q9H9V9 | 189 | 230 | 1 | 463 | Chain | ID=PRO_0000291959;Note=JmjC domain-containing protein 4 |
Q9H9V9 | 320 | 369 | 1 | 463 | Chain | ID=PRO_0000291959;Note=JmjC domain-containing protein 4 |
Q9H9V9 | 189 | 230 | 188 | 347 | Domain | Note=JmjC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00538 |
Q9H9V9 | 320 | 369 | 188 | 347 | Domain | Note=JmjC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00538 |
Q9H9V9 | 320 | 369 | 354 | 369 | Alternative sequence | ID=VSP_026324;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
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Gene expression level across TCGA pancancer |
Gene expression level across GTEx pantissue |
Expression level of gene isoforms across TCGA pancancer |
Expression level of gene isoforms across GTEx pantissue |
Cancer(tissue) type-specific expression level of Translation factor using z-score distriution |
Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples) |
Cancer type | Translation factor | FC | adj.pval |
KIRP | JMJD4 | -3.2537264485144 | 0.000557802151888609 |
KICH | JMJD4 | 1.33463623165322 | 0.00225526094436645 |
BLCA | JMJD4 | -1.52263606208823 | 0.0180816650390625 |
HNSC | JMJD4 | -5.92733825731434 | 0.049041343804447 |
COAD | JMJD4 | -2.34879785772121 | 1.2814998626709e-06 |
PRAD | JMJD4 | 1.89663309867934 | 4.73386230374949e-06 |
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Translation factor expression regulation through miRNA binding |
Cancer type | Gene | miRNA | TargetScan binding score (Context++ score percentile) | Coefficient | Pvalue |
Translation factor expression regulation through methylation in the promoter of Translation factor |
Cancer type | Gene | methyl group b | methyl group a | DEG pval | avg methyl in b | avg methyl in a | avg exp in b | avg exp in a |
Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation) |
Cancer type | Gene | methyl group b | methyl group a | DEG pval | avg methyl in b | avg methyl in a | avg exp in b | avg exp in a |
Translation factor expression regulation through copy number variation of Translation factor |
Cancer type | Gene | Coefficient | Pvalue |
UVM | JMJD4 | -0.167953156 | 0.042001382 |
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Strongly correlated genes belong to cellular important gene groups with JMJD4 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green) |
Cancer type | Gene group | Translation factor | Correlated gene | Coefficient | Pvalue |
DLBC | Cell metabolism gene | JMJD4 | GFER | 0.808720409 | 3.58E-12 |
THYM | Cell metabolism gene | JMJD4 | CYC1 | 0.801041706 | 1.63E-28 |
THYM | Cell metabolism gene | JMJD4 | SCO2 | 0.80514825 | 5.33E-29 |
THYM | Cell metabolism gene | JMJD4 | PMPCA | 0.806041285 | 4.16E-29 |
THYM | Cell metabolism gene | JMJD4 | FBXW5 | 0.80724032 | 2.98E-29 |
THYM | Cell metabolism gene | JMJD4 | GEMIN7 | 0.809058057 | 1.79E-29 |
THYM | Cell metabolism gene | JMJD4 | NME2 | 0.810277936 | 1.27E-29 |
THYM | Cell metabolism gene | JMJD4 | HMOX2 | 0.818360402 | 1.20E-30 |
THYM | Cell metabolism gene | JMJD4 | ATP5G1 | 0.824299703 | 1.98E-31 |
THYM | Cell metabolism gene | JMJD4 | MTX1 | 0.824927675 | 1.63E-31 |
THYM | Cell metabolism gene | JMJD4 | GSTP1 | 0.828530899 | 5.23E-32 |
THYM | Cell metabolism gene | JMJD4 | PYCRL | 0.828532591 | 5.23E-32 |
THYM | Cell metabolism gene | JMJD4 | PTGES2 | 0.829612264 | 3.71E-32 |
THYM | Cell metabolism gene | JMJD4 | DOHH | 0.85304835 | 1.08E-35 |
THYM | Cell metabolism gene | JMJD4 | EXOSC4 | 0.864606602 | 1.13E-37 |
THYM | CGC | JMJD4 | ASPSCR1 | 0.800437653 | 1.92E-28 |
THYM | CGC | JMJD4 | PRCC | 0.810069452 | 1.34E-29 |
THYM | Epifactor | JMJD4 | PRMT1 | 0.81712213 | 1.74E-30 |
THYM | Epifactor | JMJD4 | EXOSC4 | 0.864606602 | 1.13E-37 |
THYM | IUPHAR | JMJD4 | GPR137 | 0.801207397 | 1.56E-28 |
THYM | IUPHAR | JMJD4 | PRMT1 | 0.81712213 | 1.74E-30 |
THYM | IUPHAR | JMJD4 | HMOX2 | 0.818360402 | 1.20E-30 |
THYM | IUPHAR | JMJD4 | PTGES2 | 0.829612264 | 3.71E-32 |
THYM | TF | JMJD4 | NME2 | 0.810277936 | 1.27E-29 |
THYM | TF | JMJD4 | ZNF581 | 0.828746587 | 4.89E-32 |
THYM | TSG | JMJD4 | PHB | 0.806377248 | 3.79E-29 |
THYM | TSG | JMJD4 | GSTP1 | 0.828530899 | 5.23E-32 |
THYM | TSG | JMJD4 | STUB1 | 0.831356441 | 2.11E-32 |
UCS | Cell metabolism gene | JMJD4 | CYC1 | 0.801041706 | 1.63E-28 |
UCS | Cell metabolism gene | JMJD4 | SCO2 | 0.80514825 | 5.33E-29 |
UCS | Cell metabolism gene | JMJD4 | PMPCA | 0.806041285 | 4.16E-29 |
UCS | Cell metabolism gene | JMJD4 | FBXW5 | 0.80724032 | 2.98E-29 |
UCS | Cell metabolism gene | JMJD4 | GEMIN7 | 0.809058057 | 1.79E-29 |
UCS | Cell metabolism gene | JMJD4 | NME2 | 0.810277936 | 1.27E-29 |
UCS | Cell metabolism gene | JMJD4 | HMOX2 | 0.818360402 | 1.20E-30 |
UCS | Cell metabolism gene | JMJD4 | ATP5G1 | 0.824299703 | 1.98E-31 |
UCS | Cell metabolism gene | JMJD4 | MTX1 | 0.824927675 | 1.63E-31 |
UCS | Cell metabolism gene | JMJD4 | GSTP1 | 0.828530899 | 5.23E-32 |
UCS | Cell metabolism gene | JMJD4 | PYCRL | 0.828532591 | 5.23E-32 |
UCS | Cell metabolism gene | JMJD4 | PTGES2 | 0.829612264 | 3.71E-32 |
UCS | Cell metabolism gene | JMJD4 | DOHH | 0.85304835 | 1.08E-35 |
UCS | Cell metabolism gene | JMJD4 | EXOSC4 | 0.864606602 | 1.13E-37 |
UCS | CGC | JMJD4 | ASPSCR1 | 0.800437653 | 1.92E-28 |
UCS | CGC | JMJD4 | PRCC | 0.810069452 | 1.34E-29 |
UCS | Epifactor | JMJD4 | PRMT1 | 0.81712213 | 1.74E-30 |
UCS | Epifactor | JMJD4 | EXOSC4 | 0.864606602 | 1.13E-37 |
UCS | IUPHAR | JMJD4 | GPR137 | 0.801207397 | 1.56E-28 |
UCS | IUPHAR | JMJD4 | PRMT1 | 0.81712213 | 1.74E-30 |
UCS | IUPHAR | JMJD4 | HMOX2 | 0.818360402 | 1.20E-30 |
UCS | IUPHAR | JMJD4 | PTGES2 | 0.829612264 | 3.71E-32 |
UCS | TF | JMJD4 | NME2 | 0.810277936 | 1.27E-29 |
UCS | TF | JMJD4 | ZNF581 | 0.828746587 | 4.89E-32 |
UCS | TSG | JMJD4 | PHB | 0.806377248 | 3.79E-29 |
UCS | TSG | JMJD4 | GSTP1 | 0.828530899 | 5.23E-32 |
UCS | TSG | JMJD4 | STUB1 | 0.831356441 | 2.11E-32 |
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Protein 3D structure Visit iCn3D. |
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Protein-protein interaction networks * Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P)) |
Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P)) |
* Edge colors based on TCGA cancer types. |
* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P)) |
Cancer type | Translation factor | Interacting protein coding gene | FC | adj.pval |
KIRP | JMJD4 | ALKBH6 | -1.38137046714033 | 0.000121572986245155 |
STAD | JMJD4 | ALKBH7 | -2.25872042192086 | 0.000306400004774332 |
COAD | JMJD4 | ALKBH5 | 2.13755552147488 | 0.000465095043182374 |
THCA | JMJD4 | HSPBAP1 | -1.03404365749456 | 0.000691752404911338 |
CHOL | JMJD4 | ALKBH7 | -3.13918152894388 | 0.00390625 |
BLCA | JMJD4 | ALKBH4 | -3.09121621432787 | 0.0061798095703125 |
LUAD | JMJD4 | ALKBH7 | 1.30688246148035 | 0.00627510264512955 |
HNSC | JMJD4 | ALKBH1 | -2.39538842109683 | 0.00633394569399571 |
COAD | JMJD4 | ALKBH7 | -1.25428328459223 | 0.00793844461441041 |
KICH | JMJD4 | HSPBAP1 | 2.24200193446929 | 0.0236499309539795 |
ESCA | JMJD4 | ALKBH7 | 2.56033602674724 | 0.0244140625 |
READ | JMJD4 | ALKBH5 | 2.44404366714817 | 0.03125 |
KIRP | JMJD4 | HSPBAP1 | -2.0473861879915 | 0.0413399673998356 |
THCA | JMJD4 | ALKBH5 | -1.26370742071388 | 1.35265985423686e-05 |
LIHC | JMJD4 | ALKBH4 | -5.24591243575096 | 1.3992718911716e-05 |
LUSC | JMJD4 | ALKBH2 | -5.38089125269464 | 1.45947399043856e-08 |
LUAD | JMJD4 | ALKBH4 | -1.40168394799171 | 1.61427770148041e-05 |
LUSC | JMJD4 | ALKBH4 | -2.27982380458137 | 3.67421243367441e-07 |
KIRC | JMJD4 | ALKBH2 | -1.23743665722348 | 3.85916186028018e-07 |
HNSC | JMJD4 | ALKBH6 | -1.70752653255 | 4.83197595713137e-06 |
KIRC | JMJD4 | ALKBH5 | 1.22008443269992 | 8.228320553924e-07 |
COAD | JMJD4 | HSPBAP1 | -1.83157953562712 | 9.14931297302247e-06 |
Protein-protein interactors with this translation factor (BIOGRID-3.4.160) |
PPI interactors with JMJD4 |
SPAG8, MOV10, NXF1, RFPL4B, LIG3, RBFOX2, CHST8, PRG2, CCNJL, KRAS, SNX20, C4orf26, FAM19A3, CCT3, KIAA1683, NCAPH2, HNRNPLL, LYPD4, APOBEC3D, SSH3, CDC16, PTP4A2, ERBB2, CCT2, CCT7, CCT6A, CCT8, CCT4, CCT5, TRABD, SEC61A1, HGSNAT, TCP1, SLC16A1, SRPRB, SLC1A5, SPTLC1, PTPMT1, MRPS15, HSD17B12, ATP2A2, EMD, RPL36A, LAMP2, TUBA1A, VCPIP1, TCEB3B, DUSP16, FBXW5, SNAPC4, C10orf82, SPANXN4, STRIP1, FOSL1, SOCS7, FAM9C, LRRC23, HS3ST6, XRCC6BP1, KANSL3, PDCL3, |
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Clinically associated variants from ClinVar. |
Gene | Chr | Position | RefSeq | VarSeq | RefSeeq | VarType | Pathogenic | Disease | VarInfo |
JMJD4 | chr1 | 227921253 | G | A | single_nucleotide_variant | Benign | not_provided | SO:0001819|synonymous_variant,SO:0001627|intron_variant | SO:0001819|synonymous_variant,SO:0001627|intron_variant |
nsSNVs with sample frequency (size of circle) from TCGA 33 cancers. |
SNVs and Indels |
Gene | Cancer type | Chromosome | Start | End | RefSeeq | MutSeq | Mutation type | AAchange | # samples |
JMJD4 | ACC | chr1 | 227923081 | 227923081 | G | A | Missense_Mutation | p.A11V | 9 |
JMJD4 | COAD | chr1 | 227922918 | 227922918 | A | C | Missense_Mutation | p.D65E | 9 |
JMJD4 | PRAD | chr1 | 227920349 | 227920349 | T | G | Missense_Mutation | p.N379T | 3 |
JMJD4 | UCS | chr1 | 227922791 | 227922791 | T | C | Missense_Mutation | p.T108A | 3 |
JMJD4 | CHOL | chr1 | 227922428 | 227922428 | A | G | Missense_Mutation | 3 | |
JMJD4 | CHOL | chr1 | 227922428 | 227922428 | A | G | Missense_Mutation | p.Y164H | 3 |
JMJD4 | LUAD | chr1 | 227921232 | 227921232 | G | C | Silent | p.L281L | 3 |
JMJD4 | UCEC | chr1 | 227920657 | 227920657 | C | G | Missense_Mutation | p.Q344H | 3 |
JMJD4 | BLCA | chr1 | 227921241 | 227921241 | G | A | Silent | p.S278S | 3 |
JMJD4 | SKCM | chr1 | 227921164 | 227921164 | C | T | Missense_Mutation | p.G304D | 2 |
JMJD4 | STAD | chr1 | 227921267 | 227921267 | C | T | Missense_Mutation | p.G270S | 2 |
JMJD4 | BLCA | chr1 | 227920357 | 227920357 | C | T | Silent | 2 | |
JMJD4 | UCEC | chr1 | 227920313 | 227920313 | G | A | Missense_Mutation | p.A391V | 2 |
JMJD4 | SKCM | chr1 | 227921165 | 227921165 | C | T | Missense_Mutation | p.G304S | 2 |
JMJD4 | STAD | chr1 | 227920195 | 227920195 | C | T | Silent | p.A430A | 2 |
JMJD4 | LIHC | chr1 | 227922402 | 227922402 | G | A | Silent | p.G172G | 2 |
JMJD4 | UCEC | chr1 | 227921361 | 227921361 | G | T | Silent | p.S231Y | 2 |
JMJD4 | HNSC | chr1 | 227921284 | 227921284 | G | A | Missense_Mutation | p.A264V | 2 |
JMJD4 | SKCM | chr1 | 227923013 | 227923013 | C | T | Missense_Mutation | p.E34K | 2 |
JMJD4 | STAD | chr1 | 227922492 | 227922492 | G | A | Silent | p.N142N | 2 |
JMJD4 | UCEC | chr1 | 227921626 | 227921626 | G | A | Missense_Mutation | p.A225V | 2 |
JMJD4 | CESC | chr1 | 227920351 | 227920351 | G | C | Missense_Mutation | 2 | |
JMJD4 | STAD | chr1 | 227921375 | 227921375 | A | G | Missense_Mutation | p.F234L | 2 |
JMJD4 | KICH | chr1 | 227921193 | 227921193 | G | A | Silent | p.G294G | 2 |
JMJD4 | STAD | chr1 | 227920624 | 227920624 | G | A | Silent | p.S355S | 2 |
JMJD4 | LIHC | chr1 | 227921299 | 227921299 | G | - | Frame_Shift_Del | p.P259fs | 2 |
JMJD4 | STAD | chr1 | 227920368 | 227920368 | T | G | Silent | p.R373R | 2 |
JMJD4 | LUAD | chr1 | 227922419 | 227922419 | C | A | Nonsense_Mutation | p.E167* | 2 |
JMJD4 | STAD | chr1 | 227921267 | 227921267 | C | T | Missense_Mutation | 2 | |
JMJD4 | THCA | chr1 | 227920103 | 227920103 | G | A | Missense_Mutation | 2 | |
JMJD4 | STAD | chr1 | 227920195 | 227920195 | C | T | Silent | 2 | |
JMJD4 | SKCM | chr1 | 227923018 | 227923018 | G | A | Missense_Mutation | p.P32L | 2 |
JMJD4 | STAD | chr1 | 227920189 | 227920189 | G | A | Silent | 2 | |
JMJD4 | SKCM | chr1 | 227923019 | 227923019 | G | A | Missense_Mutation | p.P32S | 2 |
JMJD4 | STAD | chr1 | 227920189 | 227920189 | G | A | Silent | p.P432P | 2 |
JMJD4 | UCEC | chr1 | 227920302 | 227920302 | G | A | Missense_Mutation | p.L395F | 2 |
JMJD4 | GBM | chr1 | 227922480 | 227922480 | C | A | Missense_Mutation | p.Q146H | 1 |
JMJD4 | LIHC | chr1 | 227922402 | 227922402 | G | A | Silent | 1 | |
JMJD4 | BLCA | chr1 | 227920358 | 227920358 | G | A | Missense_Mutation | p.S376L | 1 |
JMJD4 | MESO | chr1 | 227921685 | 227921685 | G | A | Silent | p.S205S | 1 |
JMJD4 | HNSC | chr1 | 227921284 | 227921284 | G | A | Missense_Mutation | 1 | |
JMJD4 | BLCA | chr1 | 227922985 | 227922985 | A | T | Missense_Mutation | 1 | |
JMJD4 | BLCA | chr1 | 227921252 | 227921252 | C | T | Missense_Mutation | p.D275N | 1 |
JMJD4 | BLCA | chr1 | 227920190 | 227920190 | G | T | Missense_Mutation | 1 | |
JMJD4 | LIHC | chr1 | 227921212 | 227921212 | G | - | Frame_Shift_Del | p.P288fs | 1 |
JMJD4 | PRAD | chr1 | 227920225 | 227920225 | G | A | Silent | p.R420R | 1 |
JMJD4 | KICH | chr1 | 227921193 | 227921193 | G | A | Silent | 1 | |
JMJD4 | SKCM | chr1 | 227923098 | 227923098 | C | T | Silent | p.P5P | 1 |
JMJD4 | BLCA | chr1 | 227921241 | 227921241 | G | A | Silent | 1 | |
JMJD4 | LIHC | chr1 | 227921325 | 227921325 | C | - | Frame_Shift_Del | p.G250fs | 1 |
JMJD4 | UCS | chr1 | 227922791 | 227922791 | T | C | Missense_Mutation | 1 | |
JMJD4 | CESC | chr1 | 227920351 | 227920351 | G | C | Missense_Mutation | p.I378M | 1 |
JMJD4 | READ | chr1 | 227920209 | 227920209 | C | T | Missense_Mutation | p.A426T | 1 |
JMJD4 | SKCM | chr1 | 227920604 | 227920604 | G | A | Missense_Mutation | p.P362L | 1 |
JMJD4 | BLCA | chr1 | 227920358 | 227920358 | G | A | Missense_Mutation | 1 | |
JMJD4 | READ | chr1 | 227920251 | 227920251 | C | T | Missense_Mutation | p.E412K | 1 |
JMJD4 | KIRC | chr1 | 227921679 | 227921679 | C | T | Nonsense_Mutation | p.W207X | 1 |
JMJD4 | SKCM | chr1 | 227920378 | 227920378 | C | T | Splice_Site | 1 | |
JMJD4 | BLCA | chr1 | 227922479 | 227922479 | C | T | Missense_Mutation | 1 | |
JMJD4 | READ | chr1 | 227922372 | 227922372 | G | A | Silent | p.L182L | 1 |
JMJD4 | TGCT | chr1 | 227922874 | 227922874 | G | C | Missense_Mutation | 1 | |
JMJD4 | KIRP | chr1 | 227921688 | 227921688 | C | G | Silent | p.S204S | 1 |
JMJD4 | BLCA | chr1 | 227921252 | 227921252 | C | T | Missense_Mutation | 1 | |
JMJD4 | COAD | chr1 | 227920227 | 227920227 | G | A | Missense_Mutation | p.R420C | 1 |
JMJD4 | SARC | chr1 | 227920186 | 227920186 | G | A | Silent | 1 | |
JMJD4 | KIRP | chr1 | 227921240 | 227921240 | G | T | Missense_Mutation | 1 | |
JMJD4 | BLCA | chr1 | 227922985 | 227922985 | A | T | Missense_Mutation | p.V43E | 1 |
JMJD4 | LUAD | chr1 | 227920197 | 227920197 | C | T | Missense_Mutation | p.A430T | 1 |
JMJD4 | COAD | chr1 | 227920357 | 227920357 | C | T | Silent | p.S376S | 1 |
JMJD4 | SARC | chr1 | 227921610 | 227921610 | G | A | Silent | p.S230S | 1 |
JMJD4 | THCA | chr1 | 227922874 | 227922874 | G | C | Missense_Mutation | p.S80W | 1 |
JMJD4 | LGG | chr1 | 227920725 | 227920725 | C | T | Missense_Mutation | p.D322N | 1 |
JMJD4 | BLCA | chr1 | 227922992 | 227922992 | G | A | Nonsense_Mutation | p.R41* | 1 |
JMJD4 | LUAD | chr1 | 227920196 | 227920196 | G | A | Missense_Mutation | p.A430V | 1 |
JMJD4 | COAD | chr1 | 227920665 | 227920665 | A | G | Missense_Mutation | p.F342L | 1 |
JMJD4 | BLCA | chr1 | 227922388 | 227922388 | C | A | Missense_Mutation | 1 | |
JMJD4 | LGG | chr1 | 227920211 | 227920211 | A | G | Missense_Mutation | p.L425P | 1 |
JMJD4 | MESO | chr1 | 227921685 | 227921685 | G | A | Silent | 1 | |
JMJD4 | LGG | chr1 | 227920126 | 227920126 | C | A | Silent | 1 | |
JMJD4 | BLCA | chr1 | 227920269 | 227920269 | C | A | Missense_Mutation | 1 | |
JMJD4 | BLCA | chr1 | 227922981 | 227922981 | C | G | Silent | p.L44L | 1 |
JMJD4 | MESO | chr1 | 227921725 | 227921725 | G | T | Missense_Mutation | 1 |
Copy number variation (CNV) of JMJD4 * Click on the image to open the original image in a new window. |
Fusion gene breakpoints (product of the structural variants (SVs)) across JMJD4 * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion genes with this translation factor from FusionGDB2.0. |
FusionGDB2 ID | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
40370 | SKCM | TCGA-BF-AAP4-01A | ITCH | chr20 | 33033266 | + | JMJD4 | chr1 | 227922517 | - |
94381 | N/A | CA488852 | JMJD4 | chr1 | 227921129 | - | EFNA2 | chr19 | 1288640 | + |
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Kaplan-Meier plots with logrank tests of overall survival (OS) |
Cancer type | Translation factor | Coefficent | Hazard ratio | Wald test pval | Likelihool ratio pval | Logrank test pval | # samples |
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Differential gene expression between female and male. (Wilcoxon test, pval<0.05) |
Cancer type | Translation factor | pval | adj.p |
COAD | JMJD4 | 0.0021434288385441 | 0.06 |
TGCT | JMJD4 | 0.0135754194151596 | 0.37 |
KIRC | JMJD4 | 0.0194337600816752 | 0.51 |
ACC | JMJD4 | 0.0235770202451227 | 0.59 |
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Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05) |
Cancer type | Translation factor | pval | adj.p |
STAD | JMJD4 | 0.0241999124034913 | 0.73 |
THCA | JMJD4 | 0.00449997824762487 | 0.15 |
KIRC | JMJD4 | 0.019739374498651 | 0.61 |
LGG | JMJD4 | 0.00714198263857888 | 0.23 |
OV | JMJD4 | 0.0468040157595821 | 1 |
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Drugs targeting genes involved in this translation factor. (DrugBank Version 5.1.8 2021-05-08) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Diseases associated with this translation factor. (DisGeNet 4.0) |
Disease ID | Disease Name | # PubMeds | Disease source |