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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MRPS34 (NCBI Gene ID:65993)

Gene Summary

Gene Summary

Gene Information	Gene Name: MRPS34
	Gene ID: 65993
	Gene Symbol	MRPS34
	Gene ID	65993
	Gene Name	mitochondrial ribosomal protein S34
	Synonyms	COXPD32\|MRP-S12\|MRP-S34\|MRPS12
	Cytomap	16p13.3
	Type of Gene	protein-coding
	Description	28S ribosomal protein S34, mitochondrialS34mtmitochondrial 28S ribosomal protein S34mitochondrial small ribosomal subunit protein mS34
	Modification date	20200313
	UniProtAcc	P82930

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0032543	Mitochondrial translation
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MRPS34	(733 - 1119.25]

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Translation Studies in PubMed

We searched PubMed using 'MRPS34[title] AND translation [title] AND human.'

Gene	Title	PMID
MRPS34	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000397375	1822604	1822647	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
THCA	MRPS34	-1.45441957963461	0.00290442341112608
PRAD	MRPS34	-5.35106598630245	0.0285087588592711
LUAD	MRPS34	-2.70136571593428	2.07702654013452e-08
BRCA	MRPS34	-2.53214434739385	3.14738496193661e-22
LUSC	MRPS34	-2.71852874741784	4.28240904037329e-08

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
KIRP	MRPS34	-0.036623725	0.032390848
MESO	MRPS34	0.059689287	0.043477479

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MRPS34 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
BRCA	Cell metabolism gene	MRPS34	HMOX2	0.812349018	4.55E-287
BRCA	Cell metabolism gene	MRPS34	PGP	0.812651999	1.88E-287
BRCA	Cell metabolism gene	MRPS34	NME3	0.824737957	2.60E-303
BRCA	Cell metabolism gene	MRPS34	GFER	0.86532401	0
BRCA	CGC	MRPS34	NTHL1	0.861031784	0
BRCA	IUPHAR	MRPS34	HMOX2	0.812349018	4.55E-287
BRCA	TF	MRPS34	ZNF205	0.811325544	8.82E-286
BRCA	TF	MRPS34	E4F1	0.830391751	3.719464242771e-311
BRCA	TSG	MRPS34	STUB1	0.886402493	0
CESC	TSG	MRPS34	STUB1	0.820996371	1.81E-76
CHOL	TSG	MRPS34	STUB1	0.825204223	3.12E-12
DLBC	Cell metabolism gene	MRPS34	ADSL	0.80129522	7.88E-12
DLBC	Cell metabolism gene	MRPS34	SLC27A5	0.806163381	4.71E-12
DLBC	Cell metabolism gene	MRPS34	HAGHL	0.806196394	4.70E-12
DLBC	Cell metabolism gene	MRPS34	PSMC3	0.809877766	3.15E-12
DLBC	Cell metabolism gene	MRPS34	PAFAH1B3	0.810329998	3.00E-12
DLBC	Cell metabolism gene	MRPS34	PSMB6	0.813380568	2.14E-12
DLBC	Cell metabolism gene	MRPS34	PMPCA	0.814855227	1.81E-12
DLBC	Cell metabolism gene	MRPS34	SNRPE	0.816577425	1.49E-12
DLBC	Cell metabolism gene	MRPS34	ATP5G1	0.816929749	1.43E-12
DLBC	Cell metabolism gene	MRPS34	PSMD13	0.818012097	1.27E-12
DLBC	Cell metabolism gene	MRPS34	POLR2H	0.818931823	1.14E-12
DLBC	Cell metabolism gene	MRPS34	LSM4	0.819668254	1.05E-12
DLBC	Cell metabolism gene	MRPS34	POLR2I	0.823833852	6.41E-13
DLBC	Cell metabolism gene	MRPS34	POLR2J	0.828473846	3.66E-13
DLBC	Cell metabolism gene	MRPS34	MTX1	0.829625217	3.18E-13
DLBC	Cell metabolism gene	MRPS34	PTDSS2	0.84034014	8.06E-14
DLBC	Cell metabolism gene	MRPS34	PSMB3	0.841648354	6.77E-14
DLBC	Cell metabolism gene	MRPS34	PGP	0.852712522	1.45E-14
DLBC	Cell metabolism gene	MRPS34	TIMM50	0.860099668	4.83E-15
DLBC	Cell metabolism gene	MRPS34	EXOSC4	0.860860865	4.29E-15
DLBC	Cell metabolism gene	MRPS34	MIF	0.862737862	3.21E-15
DLBC	Cell metabolism gene	MRPS34	SNRPD3	0.865625411	2.03E-15
DLBC	Cell metabolism gene	MRPS34	POLR2L	0.867809165	1.43E-15
DLBC	Cell metabolism gene	MRPS34	GFER	0.878782054	2.20E-16
DLBC	Cell metabolism gene	MRPS34	SNRPD2	0.881437165	1.36E-16
DLBC	Cell metabolism gene	MRPS34	TIMM13	0.881918248	1.25E-16
DLBC	Cell metabolism gene	MRPS34	POLR2F	0.882741935	1.07E-16
DLBC	Cell metabolism gene	MRPS34	TOMM22	0.885430867	6.48E-17
DLBC	Cell metabolism gene	MRPS34	NME2	0.890511712	2.42E-17
DLBC	CGC	MRPS34	HRAS	0.836416576	1.35E-13
DLBC	CGC	MRPS34	NTHL1	0.837193078	1.22E-13
DLBC	Epifactor	MRPS34	MBD3	0.807259183	4.19E-12
DLBC	Epifactor	MRPS34	INO80E	0.813716866	2.06E-12
DLBC	Epifactor	MRPS34	RBX1	0.826269089	4.79E-13
DLBC	Epifactor	MRPS34	FBL	0.856535673	8.27E-15
DLBC	Epifactor	MRPS34	EXOSC4	0.860860865	4.29E-15
DLBC	IUPHAR	MRPS34	SLC27A5	0.806163381	4.71E-12
DLBC	IUPHAR	MRPS34	PSMB6	0.813380568	2.14E-12
DLBC	IUPHAR	MRPS34	BIRC5	0.823115958	6.98E-13
DLBC	IUPHAR	MRPS34	HRAS	0.836416576	1.35E-13
DLBC	TF	MRPS34	MBD3	0.807259183	4.19E-12
DLBC	TF	MRPS34	THAP7	0.833535833	1.95E-13
DLBC	TF	MRPS34	THAP4	0.853548447	1.28E-14
DLBC	TF	MRPS34	NME2	0.890511712	2.42E-17
DLBC	TSG	MRPS34	TSSC4	0.82313444	6.97E-13
DLBC	TSG	MRPS34	STUB1	0.825203872	5.44E-13
DLBC	TSG	MRPS34	PHB	0.831789366	2.43E-13
DLBC	TSG	MRPS34	PARK7	0.843915748	4.98E-14
DLBC	TSG	MRPS34	GADD45GIP1	0.912373965	1.83E-19
HNSC	Cell metabolism gene	MRPS34	PGP	0.812762377	1.92E-134
HNSC	TSG	MRPS34	STUB1	0.849122916	1.79E-158
KICH	Cell metabolism gene	MRPS34	TIMM13	0.844768439	6.77E-26
KICH	Cell metabolism gene	MRPS34	PHKG2	0.852262304	8.89E-27
KICH	Cell metabolism gene	MRPS34	PGP	0.864876848	2.23E-28
KICH	Cell metabolism gene	MRPS34	GFER	0.868088534	8.24E-29
KICH	Epifactor	MRPS34	INO80E	0.802036419	1.26E-21
KICH	IUPHAR	MRPS34	PHKG2	0.852262304	8.89E-27
KICH	Kinase	MRPS34	PHKG2	0.852262304	8.89E-27
KICH	TSG	MRPS34	STUB1	0.907643393	2.59E-35
KIRP	Cell metabolism gene	MRPS34	APRT	0.809925844	2.30E-76
KIRP	Epifactor	MRPS34	PPP4C	0.822474846	1.19E-80
KIRP	TSG	MRPS34	STUB1	0.846670067	5.87E-90
LAML	Cell metabolism gene	MRPS34	APRT	0.805960641	8.72E-41
LAML	Cell metabolism gene	MRPS34	HSD17B10	0.829398261	4.24E-45
LAML	TSG	MRPS34	GADD45GIP1	0.817764191	7.01E-43
LAML	TSG	MRPS34	STUB1	0.902801638	1.45E-64
LGG	Cell metabolism gene	MRPS34	GFER	0.824180121	1.75E-132
LGG	Cell metabolism gene	MRPS34	TIMM13	0.828379288	5.42E-135
LGG	CGC	MRPS34	NTHL1	0.865859245	6.18E-161
LGG	Epifactor	MRPS34	INO80E	0.828418137	5.13E-135
LGG	TSG	MRPS34	GADD45GIP1	0.802229994	2.27E-120
LIHC	Cell metabolism gene	MRPS34	NME3	0.803862325	5.00E-97
LIHC	TSG	MRPS34	STUB1	0.834343015	5.94E-111
LUAD	Cell metabolism gene	MRPS34	GFER	0.854662329	1.53E-165
MESO	Cell metabolism gene	MRPS34	GFER	0.810091908	2.07E-21
MESO	Cell metabolism gene	MRPS34	NME3	0.863606792	5.21E-27
MESO	TSG	MRPS34	STUB1	0.837959836	4.51E-24
PAAD	Cell metabolism gene	MRPS34	POLR2L	0.803468044	1.26E-42
PAAD	Cell metabolism gene	MRPS34	GFER	0.844710702	5.12E-51
PAAD	CGC	MRPS34	NTHL1	0.801753017	2.54E-42
PAAD	TSG	MRPS34	STUB1	0.866918976	1.27E-56
PRAD	Cell metabolism gene	MRPS34	POLR2H	0.802349527	6.36E-125
PRAD	Cell metabolism gene	MRPS34	GPX4	0.80624657	4.88E-127
PRAD	Cell metabolism gene	MRPS34	OAZ1	0.807289518	1.30E-127
PRAD	Cell metabolism gene	MRPS34	IDH3G	0.807418881	1.10E-127
PRAD	Cell metabolism gene	MRPS34	TIMM17B	0.807818241	6.64E-128
PRAD	Cell metabolism gene	MRPS34	PSMD4	0.812238916	2.19E-130
PRAD	Cell metabolism gene	MRPS34	DTYMK	0.81343689	4.55E-131
PRAD	Cell metabolism gene	MRPS34	B3GAT3	0.81462952	9.38E-132
PRAD	Cell metabolism gene	MRPS34	ACOT8	0.814774136	7.74E-132
PRAD	Cell metabolism gene	MRPS34	MTX1	0.819713579	9.84E-135
PRAD	Cell metabolism gene	MRPS34	HMOX2	0.81984428	8.23E-135
PRAD	Cell metabolism gene	MRPS34	TIMM50	0.821346456	1.04E-135
PRAD	Cell metabolism gene	MRPS34	PTGES2	0.823312662	6.71E-137
PRAD	Cell metabolism gene	MRPS34	SNRPD2	0.823799649	3.39E-137
PRAD	Cell metabolism gene	MRPS34	PSMB3	0.82436854	1.52E-137
PRAD	Cell metabolism gene	MRPS34	ATP5G1	0.824389663	1.47E-137
PRAD	Cell metabolism gene	MRPS34	DPM2	0.825091106	5.47E-138
PRAD	Cell metabolism gene	MRPS34	DPM3	0.826077668	1.34E-138
PRAD	Cell metabolism gene	MRPS34	LCMT1	0.826652222	5.92E-139
PRAD	Cell metabolism gene	MRPS34	POLR2L	0.829072775	1.80E-140
PRAD	Cell metabolism gene	MRPS34	HSD17B10	0.840106806	1.06E-147
PRAD	Cell metabolism gene	MRPS34	POLR2F	0.842956923	1.17E-149
PRAD	Cell metabolism gene	MRPS34	LSM4	0.850434055	5.49E-155
PRAD	Cell metabolism gene	MRPS34	PSMB7	0.857962795	1.18E-160
PRAD	Cell metabolism gene	MRPS34	EXOSC4	0.859033951	1.74E-161
PRAD	Cell metabolism gene	MRPS34	PGLS	0.869145808	1.05E-169
PRAD	Cell metabolism gene	MRPS34	POLR2I	0.881409584	1.22E-180
PRAD	Cell metabolism gene	MRPS34	GFER	0.887903729	6.17E-187
PRAD	Cell metabolism gene	MRPS34	TIMM13	0.888318966	2.37E-187
PRAD	Cell metabolism gene	MRPS34	NME3	0.889419031	1.84E-188
PRAD	CGC	MRPS34	MAP2K2	0.814243882	1.56E-131
PRAD	CGC	MRPS34	ASPSCR1	0.854500097	5.23E-158
PRAD	Epifactor	MRPS34	PRPF31	0.813127971	6.83E-131
PRAD	Epifactor	MRPS34	TAF10	0.820020922	6.46E-135
PRAD	Epifactor	MRPS34	ZNHIT1	0.824591519	1.11E-137
PRAD	Epifactor	MRPS34	PPP4C	0.829385706	1.14E-140
PRAD	Epifactor	MRPS34	RUVBL2	0.844822452	5.81E-151
PRAD	Epifactor	MRPS34	EXOSC4	0.859033951	1.74E-161
PRAD	IUPHAR	MRPS34	MAP2K2	0.814243882	1.56E-131
PRAD	IUPHAR	MRPS34	HMOX2	0.81984428	8.23E-135
PRAD	IUPHAR	MRPS34	PTGES2	0.823312662	6.71E-137
PRAD	IUPHAR	MRPS34	CSNK2B	0.830220296	3.37E-141
PRAD	IUPHAR	MRPS34	NR2F6	0.869639587	4.02E-170
PRAD	Kinase	MRPS34	MAP2K2	0.814243882	1.56E-131
PRAD	Kinase	MRPS34	FASTK	0.824022358	2.48E-137
PRAD	TF	MRPS34	ZNF688	0.812274659	2.09E-130
PRAD	TF	MRPS34	ZNF205	0.821933532	4.60E-136
PRAD	TF	MRPS34	NR2F6	0.869639587	4.02E-170
PRAD	TF	MRPS34	ZNF524	0.877653175	3.63E-177
PRAD	TSG	MRPS34	GADD45GIP1	0.860910882	5.81E-163
PRAD	TSG	MRPS34	STUB1	0.873751936	1.12E-173
READ	Cell metabolism gene	MRPS34	APRT	0.828702052	1.03E-27
READ	Cell metabolism gene	MRPS34	PGP	0.841414434	2.73E-29
READ	Epifactor	MRPS34	PPP4C	0.840984158	3.11E-29
READ	TSG	MRPS34	STUB1	0.825043637	2.77E-27
SKCM	TSG	MRPS34	STUB1	0.835110626	1.33E-124
TGCT	Cell metabolism gene	MRPS34	NIT2	0.802467396	2.33E-36
TGCT	Cell metabolism gene	MRPS34	TPI1	0.814317939	3.25E-38
TGCT	Cell metabolism gene	MRPS34	GEMIN7	0.818334055	7.11E-39
TGCT	Cell metabolism gene	MRPS34	LYPLA2	0.842289505	3.54E-43
TGCT	TSG	MRPS34	NIT2	0.802467396	2.33E-36
THCA	Cell metabolism gene	MRPS34	POLR2I	0.802793206	4.13E-130
THCA	Cell metabolism gene	MRPS34	PSMC5	0.806455632	3.51E-132
THCA	Cell metabolism gene	MRPS34	POLR2L	0.808453928	2.49E-133
THCA	Cell metabolism gene	MRPS34	B4GALT7	0.809771655	4.28E-134
THCA	Cell metabolism gene	MRPS34	PTGES2	0.814098764	1.19E-136
THCA	Cell metabolism gene	MRPS34	GFER	0.814753694	4.83E-137
THCA	Cell metabolism gene	MRPS34	ACOT8	0.816558819	3.93E-138
THCA	Cell metabolism gene	MRPS34	PSMB3	0.819561193	5.68E-140
THCA	Cell metabolism gene	MRPS34	TIMM13	0.826198518	3.65E-144
THCA	Cell metabolism gene	MRPS34	LSM4	0.8396908	2.92E-153
THCA	Cell metabolism gene	MRPS34	PSMB6	0.843725494	3.79E-156
THCA	Cell metabolism gene	MRPS34	EXOSC4	0.878406523	6.45E-185
THCA	Cell metabolism gene	MRPS34	APRT	0.879998454	1.92E-186
THCA	CGC	MRPS34	NTHL1	0.820992432	7.33E-141
THCA	CGC	MRPS34	ASPSCR1	0.829095544	4.75E-146
THCA	Epifactor	MRPS34	RUVBL2	0.81884523	1.57E-139
THCA	Epifactor	MRPS34	BRMS1	0.827837335	3.16E-145
THCA	Epifactor	MRPS34	ZNHIT1	0.856143397	1.43E-165
THCA	Epifactor	MRPS34	EXOSC4	0.878406523	6.45E-185
THCA	IUPHAR	MRPS34	ATP6V0B	0.810332712	2.01E-134
THCA	IUPHAR	MRPS34	PTGES2	0.814098764	1.19E-136
THCA	IUPHAR	MRPS34	PSMB6	0.843725494	3.79E-156
THCA	Kinase	MRPS34	FASTK	0.80022131	1.11E-128
THCA	TF	MRPS34	ZNF688	0.843976155	2.49E-156
THCA	TSG	MRPS34	GADD45GIP1	0.811529216	4.00E-135
THCA	TSG	MRPS34	BRMS1	0.827837335	3.16E-145
THCA	TSG	MRPS34	STUB1	0.857093648	2.50E-166
THYM	Cell metabolism gene	MRPS34	PAFAH1B3	0.802006121	1.26E-28
THYM	Cell metabolism gene	MRPS34	PCYT2	0.8027851	1.02E-28
THYM	Cell metabolism gene	MRPS34	PHPT1	0.802920952	9.81E-29
THYM	Cell metabolism gene	MRPS34	GSTZ1	0.80308234	9.39E-29
THYM	Cell metabolism gene	MRPS34	IDH3G	0.803443	8.51E-29
THYM	Cell metabolism gene	MRPS34	DGKZ	0.804220417	6.88E-29
THYM	Cell metabolism gene	MRPS34	GSTP1	0.804546488	6.29E-29
THYM	Cell metabolism gene	MRPS34	MED19	0.805320884	5.08E-29
THYM	Cell metabolism gene	MRPS34	MED27	0.808821502	1.91E-29
THYM	Cell metabolism gene	MRPS34	SSR2	0.809046783	1.80E-29
THYM	Cell metabolism gene	MRPS34	PSMB1	0.809071038	1.78E-29
THYM	Cell metabolism gene	MRPS34	UCKL1	0.810205349	1.29E-29
THYM	Cell metabolism gene	MRPS34	SNRPB	0.811568262	8.77E-30
THYM	Cell metabolism gene	MRPS34	PSMB2	0.813130489	5.59E-30
THYM	Cell metabolism gene	MRPS34	PIGU	0.814987412	3.26E-30
THYM	Cell metabolism gene	MRPS34	MMAB	0.815552314	2.76E-30
THYM	Cell metabolism gene	MRPS34	CCT7	0.816009036	2.41E-30
THYM	Cell metabolism gene	MRPS34	SEC61G	0.816913645	1.85E-30
THYM	Cell metabolism gene	MRPS34	PSME1	0.818235006	1.25E-30
THYM	Cell metabolism gene	MRPS34	PSMA7	0.818691605	1.09E-30
THYM	Cell metabolism gene	MRPS34	GALK1	0.819115872	9.59E-31
THYM	Cell metabolism gene	MRPS34	COASY	0.81913256	9.55E-31
THYM	Cell metabolism gene	MRPS34	TALDO1	0.820206434	6.91E-31
THYM	Cell metabolism gene	MRPS34	FPGS	0.824270916	1.99E-31
THYM	Cell metabolism gene	MRPS34	SNRPE	0.826612293	9.60E-32
THYM	Cell metabolism gene	MRPS34	NOP56	0.827883822	6.43E-32
THYM	Cell metabolism gene	MRPS34	PSMC4	0.828065876	6.07E-32
THYM	Cell metabolism gene	MRPS34	NME2	0.830150663	3.12E-32
THYM	Cell metabolism gene	MRPS34	POLR2F	0.830179707	3.09E-32
THYM	Cell metabolism gene	MRPS34	PFDN5	0.830409403	2.87E-32
THYM	Cell metabolism gene	MRPS34	GFER	0.831428163	2.06E-32
THYM	Cell metabolism gene	MRPS34	POLR2E	0.833355369	1.10E-32
THYM	Cell metabolism gene	MRPS34	TPI1	0.833542201	1.03E-32
THYM	Cell metabolism gene	MRPS34	DGUOK	0.834068154	8.70E-33
THYM	Cell metabolism gene	MRPS34	PSMB10	0.834425884	7.73E-33
THYM	Cell metabolism gene	MRPS34	ECHS1	0.834935975	6.53E-33
THYM	Cell metabolism gene	MRPS34	IDH3B	0.834982311	6.43E-33
THYM	Cell metabolism gene	MRPS34	POLD4	0.836300932	4.14E-33
THYM	Cell metabolism gene	MRPS34	PSMD8	0.836822841	3.47E-33
THYM	Cell metabolism gene	MRPS34	TOMM22	0.840930993	8.56E-34
THYM	Cell metabolism gene	MRPS34	TSTA3	0.843608096	3.36E-34
THYM	Cell metabolism gene	MRPS34	PSMC1	0.843827235	3.11E-34
THYM	Cell metabolism gene	MRPS34	PSMB4	0.844678979	2.30E-34
THYM	Cell metabolism gene	MRPS34	POLR3K	0.845095019	1.99E-34
THYM	Cell metabolism gene	MRPS34	POLR2J	0.8482897	6.29E-35
THYM	Cell metabolism gene	MRPS34	PSMD13	0.850999039	2.32E-35
THYM	Cell metabolism gene	MRPS34	PSMB6	0.851066384	2.26E-35
THYM	Cell metabolism gene	MRPS34	FAU	0.851426849	1.98E-35
THYM	Cell metabolism gene	MRPS34	PPCDC	0.852467844	1.34E-35
THYM	Cell metabolism gene	MRPS34	MVD	0.852789267	1.19E-35
THYM	Cell metabolism gene	MRPS34	LCMT1	0.85307962	1.07E-35
THYM	Cell metabolism gene	MRPS34	NME1	0.853561998	8.88E-36
THYM	Cell metabolism gene	MRPS34	GEMIN6	0.854440779	6.36E-36
THYM	Cell metabolism gene	MRPS34	POLE4	0.855735018	3.88E-36
THYM	Cell metabolism gene	MRPS34	PHKG2	0.85684629	2.52E-36
THYM	Cell metabolism gene	MRPS34	LSM4	0.85698947	2.39E-36
THYM	Cell metabolism gene	MRPS34	PSME2	0.85830747	1.43E-36
THYM	Cell metabolism gene	MRPS34	DPM3	0.858836604	1.16E-36
THYM	Cell metabolism gene	MRPS34	CYC1	0.85985582	7.75E-37
THYM	Cell metabolism gene	MRPS34	UROS	0.860018376	7.26E-37
THYM	Cell metabolism gene	MRPS34	OAZ1	0.861351637	4.26E-37
THYM	Cell metabolism gene	MRPS34	DTYMK	0.863949898	1.49E-37
THYM	Cell metabolism gene	MRPS34	MIF	0.866331758	5.54E-38
THYM	Cell metabolism gene	MRPS34	WBSCR22	0.866582186	4.99E-38
THYM	Cell metabolism gene	MRPS34	SRM	0.867046335	4.11E-38
THYM	Cell metabolism gene	MRPS34	PYCRL	0.869311151	1.57E-38
THYM	Cell metabolism gene	MRPS34	POLD2	0.869480109	1.46E-38
THYM	Cell metabolism gene	MRPS34	HSD17B10	0.870032741	1.15E-38
THYM	Cell metabolism gene	MRPS34	ALG3	0.870259742	1.05E-38
THYM	Cell metabolism gene	MRPS34	GMPPA	0.871733643	5.51E-39
THYM	Cell metabolism gene	MRPS34	TBCB	0.873064424	3.07E-39
THYM	Cell metabolism gene	MRPS34	EXOSC5	0.874711693	1.48E-39
THYM	Cell metabolism gene	MRPS34	SLC27A5	0.875725447	9.36E-40
THYM	Cell metabolism gene	MRPS34	TIMM17B	0.87866216	2.44E-40
THYM	Cell metabolism gene	MRPS34	EBP	0.880088293	1.25E-40
THYM	Cell metabolism gene	MRPS34	DPM2	0.881124184	7.69E-41
THYM	Cell metabolism gene	MRPS34	ITPA	0.881748109	5.72E-41
THYM	Cell metabolism gene	MRPS34	PGP	0.88362954	2.31E-41
THYM	Cell metabolism gene	MRPS34	PSMC3	0.885643238	8.64E-42
THYM	Cell metabolism gene	MRPS34	POLR2H	0.887038842	4.32E-42
THYM	Cell metabolism gene	MRPS34	HMBS	0.889881488	1.02E-42
THYM	Cell metabolism gene	MRPS34	PGLS	0.889933758	9.94E-43
THYM	Cell metabolism gene	MRPS34	NANS	0.890445141	7.63E-43
THYM	Cell metabolism gene	MRPS34	GUK1	0.891499144	4.41E-43
THYM	Cell metabolism gene	MRPS34	PSMC5	0.894324173	9.88E-44
THYM	Cell metabolism gene	MRPS34	PSMB7	0.895834321	4.36E-44
THYM	Cell metabolism gene	MRPS34	APRT	0.90125281	2.09E-45
THYM	Cell metabolism gene	MRPS34	SNRPD2	0.902677032	9.12E-46
THYM	Cell metabolism gene	MRPS34	TOMM40	0.904525119	3.05E-46
THYM	Cell metabolism gene	MRPS34	PSMD4	0.904596247	2.93E-46
THYM	Cell metabolism gene	MRPS34	TIMM10	0.904648443	2.84E-46
THYM	Cell metabolism gene	MRPS34	DOHH	0.90579954	1.42E-46
THYM	Cell metabolism gene	MRPS34	PTGES2	0.906583233	8.79E-47
THYM	Cell metabolism gene	MRPS34	ATP5G1	0.90770677	4.40E-47
THYM	Cell metabolism gene	MRPS34	HMOX2	0.910604037	7.09E-48
THYM	Cell metabolism gene	MRPS34	GEMIN7	0.911124227	5.08E-48
THYM	Cell metabolism gene	MRPS34	TIMM8B	0.914888292	4.24E-49
THYM	Cell metabolism gene	MRPS34	POLR2I	0.916164442	1.78E-49
THYM	Cell metabolism gene	MRPS34	ACOT8	0.919047673	2.38E-50
THYM	Cell metabolism gene	MRPS34	MTX1	0.91977597	1.41E-50
THYM	Cell metabolism gene	MRPS34	PSMB3	0.922299159	2.24E-51
THYM	Cell metabolism gene	MRPS34	PMPCA	0.922463343	1.99E-51
THYM	Cell metabolism gene	MRPS34	TIMM50	0.928416687	1.97E-53
THYM	Cell metabolism gene	MRPS34	TIMM13	0.933745852	2.23E-55
THYM	Cell metabolism gene	MRPS34	EXOSC4	0.968678633	1.89E-74
THYM	CGC	MRPS34	MGMT	0.805596715	4.71E-29
THYM	CGC	MRPS34	PRCC	0.810665167	1.13E-29
THYM	CGC	MRPS34	COX6C	0.822469274	3.47E-31
THYM	CGC	MRPS34	NTHL1	0.845505785	1.72E-34
THYM	CGC	MRPS34	RBM10	0.850059003	3.29E-35
THYM	CGC	MRPS34	TFPT	0.857893539	1.68E-36
THYM	CGC	MRPS34	SDHAF2	0.889086373	1.53E-42
THYM	CGC	MRPS34	ASPSCR1	0.889397222	1.31E-42
THYM	Epifactor	MRPS34	PPM1G	0.808427472	2.14E-29
THYM	Epifactor	MRPS34	PAF1	0.830661484	2.64E-32
THYM	Epifactor	MRPS34	INO80E	0.844830849	2.18E-34
THYM	Epifactor	MRPS34	C17orf49	0.850338565	2.97E-35
THYM	Epifactor	MRPS34	ZGPAT	0.851237362	2.13E-35
THYM	Epifactor	MRPS34	CDK5	0.852682126	1.24E-35
THYM	Epifactor	MRPS34	MBD3	0.853436081	9.32E-36
THYM	Epifactor	MRPS34	RUVBL2	0.856446708	2.95E-36
THYM	Epifactor	MRPS34	TFPT	0.857893539	1.68E-36
THYM	Epifactor	MRPS34	NOC2L	0.859048198	1.07E-36
THYM	Epifactor	MRPS34	LAS1L	0.863821273	1.57E-37
THYM	Epifactor	MRPS34	RRP8	0.871494505	6.12E-39
THYM	Epifactor	MRPS34	FBL	0.873682688	2.34E-39
THYM	Epifactor	MRPS34	EXOSC5	0.874711693	1.48E-39
THYM	Epifactor	MRPS34	ZNHIT1	0.877285627	4.60E-40
THYM	Epifactor	MRPS34	PPP4C	0.881024516	8.06E-41
THYM	Epifactor	MRPS34	PRMT1	0.881562828	6.25E-41
THYM	Epifactor	MRPS34	TAF10	0.88283193	3.40E-41
THYM	Epifactor	MRPS34	SIRT6	0.906869516	7.38E-47
THYM	Epifactor	MRPS34	PRPF31	0.906881091	7.33E-47
THYM	Epifactor	MRPS34	BRMS1	0.915365061	3.07E-49
THYM	Epifactor	MRPS34	EXOSC4	0.968678633	1.89E-74
THYM	IUPHAR	MRPS34	BCKDK	0.803389409	8.64E-29
THYM	IUPHAR	MRPS34	USP5	0.806456223	3.71E-29
THYM	IUPHAR	MRPS34	ABCB8	0.808193391	2.28E-29
THYM	IUPHAR	MRPS34	PSMB1	0.809071038	1.78E-29
THYM	IUPHAR	MRPS34	PSMB2	0.813130489	5.59E-30
THYM	IUPHAR	MRPS34	ECE2	0.817672654	1.48E-30
THYM	IUPHAR	MRPS34	SLC39A3	0.828018762	6.16E-32
THYM	IUPHAR	MRPS34	FKBP1A	0.840584044	9.65E-34
THYM	IUPHAR	MRPS34	PSMB6	0.851066384	2.26E-35
THYM	IUPHAR	MRPS34	CDK5	0.852682126	1.24E-35
THYM	IUPHAR	MRPS34	MVD	0.852789267	1.19E-35
THYM	IUPHAR	MRPS34	MPDU1	0.853807573	8.09E-36
THYM	IUPHAR	MRPS34	EGLN2	0.854332599	6.63E-36
THYM	IUPHAR	MRPS34	PHKG2	0.85684629	2.52E-36
THYM	IUPHAR	MRPS34	SLC27A5	0.875725447	9.36E-40
THYM	IUPHAR	MRPS34	PRMT1	0.881562828	6.25E-41
THYM	IUPHAR	MRPS34	ATP6V0B	0.888798675	1.78E-42
THYM	IUPHAR	MRPS34	PTGES2	0.906583233	8.79E-47
THYM	IUPHAR	MRPS34	SIRT6	0.906869516	7.38E-47
THYM	IUPHAR	MRPS34	HMOX2	0.910604037	7.09E-48
THYM	Kinase	MRPS34	BCKDK	0.803389409	8.64E-29
THYM	Kinase	MRPS34	FASTK	0.807081518	3.12E-29
THYM	Kinase	MRPS34	ADCK4	0.838228269	2.16E-33
THYM	Kinase	MRPS34	CDK5	0.852682126	1.24E-35
THYM	Kinase	MRPS34	PHKG2	0.85684629	2.52E-36
THYM	TF	MRPS34	IRF3	0.811556036	8.80E-30
THYM	TF	MRPS34	DRAP1	0.81195864	7.84E-30
THYM	TF	MRPS34	ZNF524	0.813883709	4.49E-30
THYM	TF	MRPS34	THAP7	0.818113039	1.29E-30
THYM	TF	MRPS34	CENPB	0.82067668	5.99E-31
THYM	TF	MRPS34	THAP3	0.82331497	2.68E-31
THYM	TF	MRPS34	NME2	0.830150663	3.12E-32
THYM	TF	MRPS34	USF1	0.830413774	2.86E-32
THYM	TF	MRPS34	ZNF428	0.832159811	1.63E-32
THYM	TF	MRPS34	ZNF511	0.835546854	5.33E-33
THYM	TF	MRPS34	GLI4	0.837259774	3.00E-33
THYM	TF	MRPS34	ZBTB48	0.83915811	1.57E-33
THYM	TF	MRPS34	REXO4	0.842964945	4.22E-34
THYM	TF	MRPS34	ZGPAT	0.851237362	2.13E-35
THYM	TF	MRPS34	MBD3	0.853436081	9.32E-36
THYM	TF	MRPS34	ZNF668	0.856225312	3.21E-36
THYM	TF	MRPS34	ZNF688	0.893209747	1.79E-43
THYM	TF	MRPS34	ZNF581	0.904624995	2.88E-46
THYM	TF	MRPS34	ZNF787	0.911741969	3.40E-48
THYM	TSG	MRPS34	GSTP1	0.804546488	6.29E-29
THYM	TSG	MRPS34	IRF3	0.811556036	8.80E-30
THYM	TSG	MRPS34	GABARAP	0.827507248	7.24E-32
THYM	TSG	MRPS34	ZBTB48	0.83915811	1.57E-33
THYM	TSG	MRPS34	PYCARD	0.841462929	7.12E-34
THYM	TSG	MRPS34	PARK7	0.846341653	1.27E-34
THYM	TSG	MRPS34	NPRL2	0.850657822	2.64E-35
THYM	TSG	MRPS34	NME1	0.853561998	8.88E-36
THYM	TSG	MRPS34	ZNF668	0.856225312	3.21E-36
THYM	TSG	MRPS34	PHB	0.869483328	1.46E-38
THYM	TSG	MRPS34	SIRT6	0.906869516	7.38E-47
THYM	TSG	MRPS34	GADD45GIP1	0.910618784	7.02E-48
THYM	TSG	MRPS34	BRMS1	0.915365061	3.07E-49
THYM	TSG	MRPS34	TSSC4	0.927058887	5.83E-53
THYM	TSG	MRPS34	STUB1	0.930674596	3.08E-54
UCEC	Cell metabolism gene	MRPS34	POLR2L	0.800068981	4.86E-46
UCEC	Cell metabolism gene	MRPS34	APRT	0.82664389	1.39E-51
UCEC	Cell metabolism gene	MRPS34	PGP	0.831077239	1.34E-52
UCEC	Cell metabolism gene	MRPS34	GFER	0.84847336	6.75E-57
UCEC	CGC	MRPS34	NTHL1	0.819550384	5.14E-50
UCS	Cell metabolism gene	MRPS34	PAFAH1B3	0.802006121	1.26E-28
UCS	Cell metabolism gene	MRPS34	PCYT2	0.8027851	1.02E-28
UCS	Cell metabolism gene	MRPS34	PHPT1	0.802920952	9.81E-29
UCS	Cell metabolism gene	MRPS34	GSTZ1	0.80308234	9.39E-29
UCS	Cell metabolism gene	MRPS34	IDH3G	0.803443	8.51E-29
UCS	Cell metabolism gene	MRPS34	DGKZ	0.804220417	6.88E-29
UCS	Cell metabolism gene	MRPS34	GSTP1	0.804546488	6.29E-29
UCS	Cell metabolism gene	MRPS34	MED19	0.805320884	5.08E-29
UCS	Cell metabolism gene	MRPS34	MED27	0.808821502	1.91E-29
UCS	Cell metabolism gene	MRPS34	SSR2	0.809046783	1.80E-29
UCS	Cell metabolism gene	MRPS34	PSMB1	0.809071038	1.78E-29
UCS	Cell metabolism gene	MRPS34	UCKL1	0.810205349	1.29E-29
UCS	Cell metabolism gene	MRPS34	SNRPB	0.811568262	8.77E-30
UCS	Cell metabolism gene	MRPS34	PSMB2	0.813130489	5.59E-30
UCS	Cell metabolism gene	MRPS34	PIGU	0.814987412	3.26E-30
UCS	Cell metabolism gene	MRPS34	MMAB	0.815552314	2.76E-30
UCS	Cell metabolism gene	MRPS34	CCT7	0.816009036	2.41E-30
UCS	Cell metabolism gene	MRPS34	SEC61G	0.816913645	1.85E-30
UCS	Cell metabolism gene	MRPS34	PSME1	0.818235006	1.25E-30
UCS	Cell metabolism gene	MRPS34	PSMA7	0.818691605	1.09E-30
UCS	Cell metabolism gene	MRPS34	GALK1	0.819115872	9.59E-31
UCS	Cell metabolism gene	MRPS34	COASY	0.81913256	9.55E-31
UCS	Cell metabolism gene	MRPS34	TALDO1	0.820206434	6.91E-31
UCS	Cell metabolism gene	MRPS34	FPGS	0.824270916	1.99E-31
UCS	Cell metabolism gene	MRPS34	SNRPE	0.826612293	9.60E-32
UCS	Cell metabolism gene	MRPS34	NOP56	0.827883822	6.43E-32
UCS	Cell metabolism gene	MRPS34	PSMC4	0.828065876	6.07E-32
UCS	Cell metabolism gene	MRPS34	NME2	0.830150663	3.12E-32
UCS	Cell metabolism gene	MRPS34	POLR2F	0.830179707	3.09E-32
UCS	Cell metabolism gene	MRPS34	PFDN5	0.830409403	2.87E-32
UCS	Cell metabolism gene	MRPS34	GFER	0.831428163	2.06E-32
UCS	Cell metabolism gene	MRPS34	POLR2E	0.833355369	1.10E-32
UCS	Cell metabolism gene	MRPS34	TPI1	0.833542201	1.03E-32
UCS	Cell metabolism gene	MRPS34	DGUOK	0.834068154	8.70E-33
UCS	Cell metabolism gene	MRPS34	PSMB10	0.834425884	7.73E-33
UCS	Cell metabolism gene	MRPS34	ECHS1	0.834935975	6.53E-33
UCS	Cell metabolism gene	MRPS34	IDH3B	0.834982311	6.43E-33
UCS	Cell metabolism gene	MRPS34	POLD4	0.836300932	4.14E-33
UCS	Cell metabolism gene	MRPS34	PSMD8	0.836822841	3.47E-33
UCS	Cell metabolism gene	MRPS34	TOMM22	0.840930993	8.56E-34
UCS	Cell metabolism gene	MRPS34	TSTA3	0.843608096	3.36E-34
UCS	Cell metabolism gene	MRPS34	PSMC1	0.843827235	3.11E-34
UCS	Cell metabolism gene	MRPS34	PSMB4	0.844678979	2.30E-34
UCS	Cell metabolism gene	MRPS34	POLR3K	0.845095019	1.99E-34
UCS	Cell metabolism gene	MRPS34	POLR2J	0.8482897	6.29E-35
UCS	Cell metabolism gene	MRPS34	PSMD13	0.850999039	2.32E-35
UCS	Cell metabolism gene	MRPS34	PSMB6	0.851066384	2.26E-35
UCS	Cell metabolism gene	MRPS34	FAU	0.851426849	1.98E-35
UCS	Cell metabolism gene	MRPS34	PPCDC	0.852467844	1.34E-35
UCS	Cell metabolism gene	MRPS34	MVD	0.852789267	1.19E-35
UCS	Cell metabolism gene	MRPS34	LCMT1	0.85307962	1.07E-35
UCS	Cell metabolism gene	MRPS34	NME1	0.853561998	8.88E-36
UCS	Cell metabolism gene	MRPS34	GEMIN6	0.854440779	6.36E-36
UCS	Cell metabolism gene	MRPS34	POLE4	0.855735018	3.88E-36
UCS	Cell metabolism gene	MRPS34	PHKG2	0.85684629	2.52E-36
UCS	Cell metabolism gene	MRPS34	LSM4	0.85698947	2.39E-36
UCS	Cell metabolism gene	MRPS34	PSME2	0.85830747	1.43E-36
UCS	Cell metabolism gene	MRPS34	DPM3	0.858836604	1.16E-36
UCS	Cell metabolism gene	MRPS34	CYC1	0.85985582	7.75E-37
UCS	Cell metabolism gene	MRPS34	UROS	0.860018376	7.26E-37
UCS	Cell metabolism gene	MRPS34	OAZ1	0.861351637	4.26E-37
UCS	Cell metabolism gene	MRPS34	DTYMK	0.863949898	1.49E-37
UCS	Cell metabolism gene	MRPS34	MIF	0.866331758	5.54E-38
UCS	Cell metabolism gene	MRPS34	WBSCR22	0.866582186	4.99E-38
UCS	Cell metabolism gene	MRPS34	SRM	0.867046335	4.11E-38
UCS	Cell metabolism gene	MRPS34	PYCRL	0.869311151	1.57E-38
UCS	Cell metabolism gene	MRPS34	POLD2	0.869480109	1.46E-38
UCS	Cell metabolism gene	MRPS34	HSD17B10	0.870032741	1.15E-38
UCS	Cell metabolism gene	MRPS34	ALG3	0.870259742	1.05E-38
UCS	Cell metabolism gene	MRPS34	GMPPA	0.871733643	5.51E-39
UCS	Cell metabolism gene	MRPS34	TBCB	0.873064424	3.07E-39
UCS	Cell metabolism gene	MRPS34	EXOSC5	0.874711693	1.48E-39
UCS	Cell metabolism gene	MRPS34	SLC27A5	0.875725447	9.36E-40
UCS	Cell metabolism gene	MRPS34	TIMM17B	0.87866216	2.44E-40
UCS	Cell metabolism gene	MRPS34	EBP	0.880088293	1.25E-40
UCS	Cell metabolism gene	MRPS34	DPM2	0.881124184	7.69E-41
UCS	Cell metabolism gene	MRPS34	ITPA	0.881748109	5.72E-41
UCS	Cell metabolism gene	MRPS34	PGP	0.88362954	2.31E-41
UCS	Cell metabolism gene	MRPS34	PSMC3	0.885643238	8.64E-42
UCS	Cell metabolism gene	MRPS34	POLR2H	0.887038842	4.32E-42
UCS	Cell metabolism gene	MRPS34	HMBS	0.889881488	1.02E-42
UCS	Cell metabolism gene	MRPS34	PGLS	0.889933758	9.94E-43
UCS	Cell metabolism gene	MRPS34	NANS	0.890445141	7.63E-43
UCS	Cell metabolism gene	MRPS34	GUK1	0.891499144	4.41E-43
UCS	Cell metabolism gene	MRPS34	PSMC5	0.894324173	9.88E-44
UCS	Cell metabolism gene	MRPS34	PSMB7	0.895834321	4.36E-44
UCS	Cell metabolism gene	MRPS34	APRT	0.90125281	2.09E-45
UCS	Cell metabolism gene	MRPS34	SNRPD2	0.902677032	9.12E-46
UCS	Cell metabolism gene	MRPS34	TOMM40	0.904525119	3.05E-46
UCS	Cell metabolism gene	MRPS34	PSMD4	0.904596247	2.93E-46
UCS	Cell metabolism gene	MRPS34	TIMM10	0.904648443	2.84E-46
UCS	Cell metabolism gene	MRPS34	DOHH	0.90579954	1.42E-46
UCS	Cell metabolism gene	MRPS34	PTGES2	0.906583233	8.79E-47
UCS	Cell metabolism gene	MRPS34	ATP5G1	0.90770677	4.40E-47
UCS	Cell metabolism gene	MRPS34	HMOX2	0.910604037	7.09E-48
UCS	Cell metabolism gene	MRPS34	GEMIN7	0.911124227	5.08E-48
UCS	Cell metabolism gene	MRPS34	TIMM8B	0.914888292	4.24E-49
UCS	Cell metabolism gene	MRPS34	POLR2I	0.916164442	1.78E-49
UCS	Cell metabolism gene	MRPS34	ACOT8	0.919047673	2.38E-50
UCS	Cell metabolism gene	MRPS34	MTX1	0.91977597	1.41E-50
UCS	Cell metabolism gene	MRPS34	PSMB3	0.922299159	2.24E-51
UCS	Cell metabolism gene	MRPS34	PMPCA	0.922463343	1.99E-51
UCS	Cell metabolism gene	MRPS34	TIMM50	0.928416687	1.97E-53
UCS	Cell metabolism gene	MRPS34	TIMM13	0.933745852	2.23E-55
UCS	Cell metabolism gene	MRPS34	EXOSC4	0.968678633	1.89E-74
UCS	CGC	MRPS34	MGMT	0.805596715	4.71E-29
UCS	CGC	MRPS34	PRCC	0.810665167	1.13E-29
UCS	CGC	MRPS34	COX6C	0.822469274	3.47E-31
UCS	CGC	MRPS34	NTHL1	0.845505785	1.72E-34
UCS	CGC	MRPS34	RBM10	0.850059003	3.29E-35
UCS	CGC	MRPS34	TFPT	0.857893539	1.68E-36
UCS	CGC	MRPS34	SDHAF2	0.889086373	1.53E-42
UCS	CGC	MRPS34	ASPSCR1	0.889397222	1.31E-42
UCS	Epifactor	MRPS34	PPM1G	0.808427472	2.14E-29
UCS	Epifactor	MRPS34	PAF1	0.830661484	2.64E-32
UCS	Epifactor	MRPS34	INO80E	0.844830849	2.18E-34
UCS	Epifactor	MRPS34	C17orf49	0.850338565	2.97E-35
UCS	Epifactor	MRPS34	ZGPAT	0.851237362	2.13E-35
UCS	Epifactor	MRPS34	CDK5	0.852682126	1.24E-35
UCS	Epifactor	MRPS34	MBD3	0.853436081	9.32E-36
UCS	Epifactor	MRPS34	RUVBL2	0.856446708	2.95E-36
UCS	Epifactor	MRPS34	TFPT	0.857893539	1.68E-36
UCS	Epifactor	MRPS34	NOC2L	0.859048198	1.07E-36
UCS	Epifactor	MRPS34	LAS1L	0.863821273	1.57E-37
UCS	Epifactor	MRPS34	RRP8	0.871494505	6.12E-39
UCS	Epifactor	MRPS34	FBL	0.873682688	2.34E-39
UCS	Epifactor	MRPS34	EXOSC5	0.874711693	1.48E-39
UCS	Epifactor	MRPS34	ZNHIT1	0.877285627	4.60E-40
UCS	Epifactor	MRPS34	PPP4C	0.881024516	8.06E-41
UCS	Epifactor	MRPS34	PRMT1	0.881562828	6.25E-41
UCS	Epifactor	MRPS34	TAF10	0.88283193	3.40E-41
UCS	Epifactor	MRPS34	SIRT6	0.906869516	7.38E-47
UCS	Epifactor	MRPS34	PRPF31	0.906881091	7.33E-47
UCS	Epifactor	MRPS34	BRMS1	0.915365061	3.07E-49
UCS	Epifactor	MRPS34	EXOSC4	0.968678633	1.89E-74
UCS	IUPHAR	MRPS34	BCKDK	0.803389409	8.64E-29
UCS	IUPHAR	MRPS34	USP5	0.806456223	3.71E-29
UCS	IUPHAR	MRPS34	ABCB8	0.808193391	2.28E-29
UCS	IUPHAR	MRPS34	PSMB1	0.809071038	1.78E-29
UCS	IUPHAR	MRPS34	PSMB2	0.813130489	5.59E-30
UCS	IUPHAR	MRPS34	ECE2	0.817672654	1.48E-30
UCS	IUPHAR	MRPS34	SLC39A3	0.828018762	6.16E-32
UCS	IUPHAR	MRPS34	FKBP1A	0.840584044	9.65E-34
UCS	IUPHAR	MRPS34	PSMB6	0.851066384	2.26E-35
UCS	IUPHAR	MRPS34	CDK5	0.852682126	1.24E-35
UCS	IUPHAR	MRPS34	MVD	0.852789267	1.19E-35
UCS	IUPHAR	MRPS34	MPDU1	0.853807573	8.09E-36
UCS	IUPHAR	MRPS34	EGLN2	0.854332599	6.63E-36
UCS	IUPHAR	MRPS34	PHKG2	0.85684629	2.52E-36
UCS	IUPHAR	MRPS34	SLC27A5	0.875725447	9.36E-40
UCS	IUPHAR	MRPS34	PRMT1	0.881562828	6.25E-41
UCS	IUPHAR	MRPS34	ATP6V0B	0.888798675	1.78E-42
UCS	IUPHAR	MRPS34	PTGES2	0.906583233	8.79E-47
UCS	IUPHAR	MRPS34	SIRT6	0.906869516	7.38E-47
UCS	IUPHAR	MRPS34	HMOX2	0.910604037	7.09E-48
UCS	Kinase	MRPS34	BCKDK	0.803389409	8.64E-29
UCS	Kinase	MRPS34	FASTK	0.807081518	3.12E-29
UCS	Kinase	MRPS34	ADCK4	0.838228269	2.16E-33
UCS	Kinase	MRPS34	CDK5	0.852682126	1.24E-35
UCS	Kinase	MRPS34	PHKG2	0.85684629	2.52E-36
UCS	TF	MRPS34	IRF3	0.811556036	8.80E-30
UCS	TF	MRPS34	DRAP1	0.81195864	7.84E-30
UCS	TF	MRPS34	ZNF524	0.813883709	4.49E-30
UCS	TF	MRPS34	THAP7	0.818113039	1.29E-30
UCS	TF	MRPS34	CENPB	0.82067668	5.99E-31
UCS	TF	MRPS34	THAP3	0.82331497	2.68E-31
UCS	TF	MRPS34	NME2	0.830150663	3.12E-32
UCS	TF	MRPS34	USF1	0.830413774	2.86E-32
UCS	TF	MRPS34	ZNF428	0.832159811	1.63E-32
UCS	TF	MRPS34	ZNF511	0.835546854	5.33E-33
UCS	TF	MRPS34	GLI4	0.837259774	3.00E-33
UCS	TF	MRPS34	ZBTB48	0.83915811	1.57E-33
UCS	TF	MRPS34	REXO4	0.842964945	4.22E-34
UCS	TF	MRPS34	ZGPAT	0.851237362	2.13E-35
UCS	TF	MRPS34	MBD3	0.853436081	9.32E-36
UCS	TF	MRPS34	ZNF668	0.856225312	3.21E-36
UCS	TF	MRPS34	ZNF688	0.893209747	1.79E-43
UCS	TF	MRPS34	ZNF581	0.904624995	2.88E-46
UCS	TF	MRPS34	ZNF787	0.911741969	3.40E-48
UCS	TSG	MRPS34	GSTP1	0.804546488	6.29E-29
UCS	TSG	MRPS34	IRF3	0.811556036	8.80E-30
UCS	TSG	MRPS34	GABARAP	0.827507248	7.24E-32
UCS	TSG	MRPS34	ZBTB48	0.83915811	1.57E-33
UCS	TSG	MRPS34	PYCARD	0.841462929	7.12E-34
UCS	TSG	MRPS34	PARK7	0.846341653	1.27E-34
UCS	TSG	MRPS34	NPRL2	0.850657822	2.64E-35
UCS	TSG	MRPS34	NME1	0.853561998	8.88E-36
UCS	TSG	MRPS34	ZNF668	0.856225312	3.21E-36
UCS	TSG	MRPS34	PHB	0.869483328	1.46E-38
UCS	TSG	MRPS34	SIRT6	0.906869516	7.38E-47
UCS	TSG	MRPS34	GADD45GIP1	0.910618784	7.02E-48
UCS	TSG	MRPS34	BRMS1	0.915365061	3.07E-49
UCS	TSG	MRPS34	TSSC4	0.927058887	5.83E-53
UCS	TSG	MRPS34	STUB1	0.930674596	3.08E-54
UVM	Cell metabolism gene	MRPS34	POLR2E	0.800139455	5.42E-19
UVM	Cell metabolism gene	MRPS34	G6PC3	0.802866424	3.35E-19
UVM	Cell metabolism gene	MRPS34	EXOSC4	0.813925539	4.42E-20
UVM	Cell metabolism gene	MRPS34	DPM2	0.820763306	1.18E-20
UVM	Cell metabolism gene	MRPS34	PSMC4	0.827163679	3.25E-21
UVM	Cell metabolism gene	MRPS34	TOMM40	0.82725202	3.19E-21
UVM	Cell metabolism gene	MRPS34	PSMD8	0.830261975	1.71E-21
UVM	Cell metabolism gene	MRPS34	MTX1	0.833966474	7.78E-22
UVM	Cell metabolism gene	MRPS34	SCO2	0.897950293	1.57E-29
UVM	Epifactor	MRPS34	EXOSC4	0.813925539	4.42E-20
UVM	IUPHAR	MRPS34	MPDU1	0.831424519	1.34E-21
UVM	TF	MRPS34	ZNF668	0.804650109	2.44E-19
UVM	TSG	MRPS34	ZNF668	0.804650109	2.44E-19
UVM	TSG	MRPS34	PFN1	0.854643204	6.57E-24

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
BRCA	MRPS34	MRPS27	-2.1331392862776	0.000127527962379903
LIHC	MRPS34	MRPS31	-1.07565232256163	0.000180054839259286
BRCA	MRPS34	MRPS15	-2.19567551682318	0.000188684660674703
HNSC	MRPS34	MRPS23	-1.64850118241992	0.0007221434505027
THCA	MRPS34	MRPS23	1.86640051281615	0.000772056397653126
STAD	MRPS34	MRPS16	-1.64208084987431	0.00239070039242506
LUAD	MRPS34	MRPS31	1.58140915700442	0.00351308111790755
KIRC	MRPS34	MRPS15	1.11572283836012	0.00361818577801855
CHOL	MRPS34	MRPS23	-3.47507217165732	0.00390625
HNSC	MRPS34	MRPS16	-2.01564621821803	0.00518989327406416
KICH	MRPS34	MRPS2	1.26543989555015	0.0114533305168152
THCA	MRPS34	MRPS15	-1.19960602422995	0.0140154883942907
KICH	MRPS34	MRPS31	-1.44171613577495	0.0173123478889465
ESCA	MRPS34	MRPS2	-3.20556788084675	0.0244140625
COAD	MRPS34	MRPS25	-1.06378818334118	0.0253507494926453
COAD	MRPS34	MRPS31	1.25930610083678	0.0253507494926453
BLCA	MRPS34	MRPS31	-1.74989716581638	0.0445594787597656
KICH	MRPS34	MRPS22	1.59345779884986	0.0451226830482483
LIHC	MRPS34	MRPS23	-3.60547266789887	1.76596269781643e-07
LUSC	MRPS34	MRPS2	-2.70930846488508	1.92864354932136e-09
LUAD	MRPS34	MRPS27	-2.46461120873599	2.13247131179291e-05
LUAD	MRPS34	MRPL42	-6.34610249602491	2.48255276366547e-08
LUSC	MRPS34	MRPS26	-3.32725244934649	2.86720468728312e-07
THCA	MRPS34	MRPS25	1.74913237408154	4.20046426016336e-09
LIHC	MRPS34	MRPS2	-1.14771055358828	4.2584580238307e-05
KIRC	MRPS34	MRPL42	-4.382095336248	5.26630854166927e-06
PRAD	MRPS34	MRPS31	1.42878008978338	6.76861513404814e-05
THCA	MRPS34	MRPS31	-1.55759809933211	6.91106419786075e-09
KIRC	MRPS34	MRPS31	-4.32541004240865	9.31897250092369e-08
HNSC	MRPS34	MRPS25	1.58119296482122	9.87721932688148e-07

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MRPS34

NFKBIL1, DDX56, USP42, MYC, ICT1, Ybx1, CUL3, CAND1, HNRNPU, SLC25A5, ATP5J2, ILF2, FN1, C1QBP, TARDBP, GRSF1, CEP250, TUBG1, MOV10, BTRC, FBXW11, RPL6, RPS8, TRMT10B, ZNF707, MRPS31, NTRK1, Rpl35, Ksr1, ERBB3, POU5F1, ZNF746, CDC14B, MTMR7, NINL, MRPS27, EPDR1, PSMG4, DDX55, MRPS18C, NOA1, MRPS33, MRPS35, MRPS9, DAP3, MRPS14, MRPS21, MRPS25, PTCD3, MRPS18B, MRPS2, PSMG3, FAM92A1, MRPS10, MRPS11, MRPS28, MRPS22, STRBP, MRPS5, MRPS15, ZBTB48, MRPS7, MRPS24, MRPS16, MRPS6, HIST1H1A, MRPS23, MRPS26, SUPV3L1, ZZEF1, PSME3, PDF, GNL2, PREPL, MCAT, IGF2BP3, IGF2BP1, FAM192A, ZNF574, HECTD3, ZNF770, NCL, BRD1, PPP2R2B, PCBP1, PYHIN1, EFTUD2, LARP7, ESR2, HEXIM1, MEPCE, SNAI1, RECQL4, HABP4, SERBP1, MB21D1, FBL, HIST1H3A, RPS6, MRM1, HSPD1, PDK1, TRMT61B, AURKAIP1, RC3H1, PHB, TCF7L2, ALYREF, SNRNP70, Dppa3, ITFG1, HMGB1, BIRC3, TRIM28, SQSTM1, PLEKHA4, AXL, GRB7, MTA2, PRKCI, PTPRR, ESR1, IMMP2L, CELF1, ELAVL1, IGF2BP2, MEX3B, PRRC2A, XRN2, ZC3HAV1, SMG7, SYNCRIP, CIT, CHMP4C, KIF14, KIF20A, PRC1, ACAD9, AUH, C12orf65, C17orf80, C21orf33, C6orf203, C8orf82, MCUR1, CCDC90B, CHCHD1, CLPB, COX15, CRYZ, CS, DDX28, DHX30, EXD2, FASTKD2, FASTKD3, FASTKD5, GFM1, GFM2, HINT2, LONP1, LRPPRC, MCU, CCDC109B, MDH2, METTL15, METTL17, MRPL11, MRPS12, MRRF, MTERF3, MTFMT, MTG1, MTG2, MTIF2, MTIF3, MTRF1, MTRF1L, NGRN, OTC, PMPCA, PMPCB, RMND1, RPUSD3, RPUSD4, SLC25A51, SLIRP, SSBP1, SURF1, TACO1, TBRG4, TEFM, TFAM, C19orf52, TMEM70, TRUB2, TSFM, TUFM, VWA8, INS, MAFB, Apc2, DNAJC15, DNAJC30, DNAJA3, DNAJC19, DNAJC28, HSCB, TSPYL1, MRPS17, MRPL41, CDK4, UFL1, DDRGK1, AARS2, COX4I1, COX8A, PDHA1, SKA3, USP15, FZR1, MAP4K3, MAP4K4, ZBTB2, FAM120A, KBTBD7, SRSF6, GLTSCR2, PRR3, YBX1, RPS9, GLI4, SRSF3, RRS1, ABT1, SRSF7, RPL35, RPL26L1, LIN28A, PRKRIR, CTCF, SRP14, RPL36AL, APOBEC3D, RPL13, RPL10, DKC1, ZNF346, RBMS2, NEIL1, ZC3H3, ERAL1, RPL4, MRPL2, H1FNT, FSCN1, KLF12, LHX2, SOX15, SOX2, TLX2, KLF15, KLF16, KLF4, KLF8, SOX5,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
MRPS34	chr16	1822159	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
MRPS34	chr16	1822657	C	T	single_nucleotide_variant	Pathogenic	Combined_oxidative_phosphorylation_deficiency_32\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPS34	chr16	1822799	C	A	single_nucleotide_variant	Pathogenic	Leigh_syndrome\|Combined_oxidative_phosphorylation_deficiency_32	SO:0001575\|splice_donor_variant	SO:0001575\|splice_donor_variant
MRPS34	chr16	1822947	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant	SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant
MRPS34	chr16	1823024	G	T	single_nucleotide_variant	Benign	Combined_oxidative_phosphorylation_deficiency_32\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPS34	chr16	1823027	G	A	single_nucleotide_variant	Pathogenic/Likely_pathogenic	Combined_oxidative_phosphorylation_deficiency_32\|not_provided	SO:0001587\|nonsense	SO:0001587\|nonsense
MRPS34	chr16	1823084	C	T	single_nucleotide_variant	Likely_pathogenic	Leigh_syndrome\|Combined_oxidative_phosphorylation_deficiency_32	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MRPS34	chr16	1823098	G	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MRPS34	ACC	chr16	1822947	1822947	C	G	Silent	p.V58V	8
MRPS34	ACC	chr16	1823054	1823054	C	G	Missense_Mutation	p.E23Q	3
MRPS34	BRCA	chr16	1822797	1822798	-	ACCT	Splice_Site	e1+2	3
MRPS34	COAD	chr16	1823024	1823024	G	T	Missense_Mutation	p.L33I	3
MRPS34	SARC	chr16	1822314	1822314	G	T	Missense_Mutation		2
MRPS34	BLCA	chr16	1822511	1822511	T	C	Missense_Mutation	p.K123R	2
MRPS34	LIHC	chr16	1822357	1822357	A	-	Frame_Shift_Del	p.I182fs	2
MRPS34	ESCA	chr16	1822500	1822500	C	G	Missense_Mutation	p.E127Q	2
MRPS34	PAAD	chr16	1822318	1822318	C	A	Missense_Mutation		2
MRPS34	ESCA	chr16	1822500	1822500	C	G	Missense_Mutation		2
MRPS34	PAAD	chr16	1822318	1822318	C	A	Missense_Mutation	p.E187D	2
MRPS34	PAAD	chr16	1822318	1822318	C	A	Missense_Mutation	p.E194D	1
MRPS34	BLCA	chr16	1822520	1822520	G	A	Missense_Mutation		1
MRPS34	GBM	chr16	1823074	1823075	-	G	Frame_Shift_Ins	p.R16fs	1
MRPS34	READ	chr16	1822399	1822399	G	A	Silent	p.S160S	1
MRPS34	BLCA	chr16	1822222	1822222	C	T	Silent	p.226	1
MRPS34	HNSC	chr16	1822228	1822228	G	T	Silent		1
MRPS34	BLCA	chr16	1822451	1822451	G	C	Missense_Mutation	p.P150R	1
MRPS34	KICH	chr16	1822532	1822532	G	A	Missense_Mutation		1
MRPS34	SARC	chr16	1822314	1822314	G	T	Missense_Mutation	p.P196T	1
MRPS34	BLCA	chr16	1822510	1822510	C	G	Missense_Mutation	p.K130N	1
MRPS34	KIRP	chr16	1823047	1823047	A	C	Missense_Mutation	p.L25R	1
MRPS34	SKCM	chr16	1822442	1822442	T	A	Missense_Mutation	p.E146V	1
MRPS34	LIHC	chr16	1822499	1822499	T	C	Missense_Mutation		1
MRPS34	SKCM	chr16	1822335	1822335	C	T	Missense_Mutation	p.G182R	1
MRPS34	BLCA	chr16	1822451	1822451	G	C	Missense_Mutation	p.P143R	1
MRPS34	SKCM	chr16	1822335	1822335	C	T	Missense_Mutation	p.G189R	1
MRPS34	LUAD	chr16	1822333	1822333	T	C	Silent	p.G189G	1
MRPS34	SKCM	chr16	1822442	1822442	T	A	Missense_Mutation	p.E153V	1
MRPS34	LUAD	chr16	1822357	1822357	A	T	Silent	p.I181I	1
MRPS34	BLCA	chr16	1822511	1822511	T	C	Missense_Mutation		1
MRPS34	BLCA	chr16	1822451	1822451	G	C	Missense_Mutation		1
MRPS34	BLCA	chr16	1822510	1822510	C	G	Missense_Mutation		1
MRPS34	ESCA	chr16	1822500	1822500	C	G	Missense_Mutation	p.E134Q	1

Copy number variation (CNV) of MRPS34
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MRPS34
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
61990	N/A	BE928604	MRPS34	chr16	1822886	+	OTX1	chr2	63283328	+
97904	N/A	AI634126	MRPS34	chr16	1822023	-	PRKDC	chr8	48685673	+
98994	N/A	AA973233	MRPS34	chr16	1822162	+	ST6GAL1	chr3	186795665	-
83116	N/A	CK819899	SLC38A5	chrX	48317315	+	MRPS34	chr16	1822017	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRP	MRPS34	0.00165424215641441	0.046
TGCT	MRPS34	0.022570824571068	0.61

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
THCA	MRPS34	0.0008318015704707	0.027
KIRP	MRPS34	0.0397702117727107	1
LGG	MRPS34	0.0247273234383115	0.74
BRCA	MRPS34	0.014376552674964	0.45
SARC	MRPS34	0.00462963324828614	0.15
MESO	MRPS34	0.025819528219697	0.75

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C4540029	COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 32	1	GENOMICS_ENGLAND;UNIPROT