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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: BOLL (NCBI Gene ID:66037)

Gene Summary

Gene Summary

Gene Information	Gene Name: BOLL
	Gene ID: 66037
	Gene Symbol	BOLL
	Gene ID	66037
	Gene Name	boule homolog, RNA binding protein
	Synonyms	BOULE
	Cytomap	2q33.1
	Type of Gene	protein-coding
	Description	protein boule-likebol, boule-likeboule-like RNA binding protein
	Modification date	20200313
	UniProtAcc	Q8N9W6

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0045727	Positive regulation of translation
GO:0006413	Translational initiation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	BOLL	GO:0045948	positive regulation of translational initiation	16001084
Hgene	BOLL	GO:0051321	meiotic cell cycle	12499397

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
BOLL	(733 - 1119.25]

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Translation Studies in PubMed

We searched PubMed using 'BOLL[title] AND translation [title] AND human.'

Gene	Title	PMID
BOLL	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000392296	198631255	198631327	In-frame
ENST00000433157	198631255	198631327	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000433157	198631255	198631327	1287	878	949	283	160	184
ENST00000392296	198631255	198631327	2855	791	862	283	160	184

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q8N9W6	160	184	1	283	Chain	ID=PRO_0000081494;Note=Protein boule-like
Q8N9W6	160	184	1	283	Chain	ID=PRO_0000081494;Note=Protein boule-like
Q8N9W6	160	184	164	194	Domain	Note=DAZ-like
Q8N9W6	160	184	164	194	Domain	Note=DAZ-like
Q8N9W6	160	184	184	184	Alternative sequence	ID=VSP_009445;Note=In isoform 2. Q->QGIKQCHTRRWMDSLLPFTKCDE;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q8N9W6	160	184	184	184	Alternative sequence	ID=VSP_009445;Note=In isoform 2. Q->QGIKQCHTRRWMDSLLPFTKCDE;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q8N9W6	160	184	164	164	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8N9W6	160	184	164	164	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUAD	BOLL	-2.4051480710075	0.000674999578129208
STAD	BOLL	2.55102711734125	0.00124124338178691
ESCA	BOLL	1.92647940920784	0.001953125

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
DLBC	BOLL	hsa-miR-21-5p	90	0.36667832165926	0.0112411650849166

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
ACC	BOLL	2	3	0.0219459949116297	0.524952268907563	0.668855882352941	-0.702508488377719	-1.20331277409089
STAD	BOLL	2	3	0.00828446972594399	0.534617279411765	0.750575654376583	0.236194100907194	-0.0329965539970453

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with BOLL (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type

Gene group

Translation factor

Correlated gene

Coefficient

Pvalue

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KICH	BOLL	UBA5	1.10073517507285	0.000187873840332031
THCA	BOLL	CDC20B	-1.26841074776315	0.000736378636077499
LIHC	BOLL	CDC20B	-1.60087118453884	0.00114894782237622
KIRP	BOLL	CPEB1	2.39393200480884	0.00361521635204554
STAD	BOLL	UBA5	1.05007959700362	0.00471024587750435
BLCA	BOLL	CDC20B	-1.09938437735159	0.00522300384127411
LIHC	BOLL	DDX4	-1.38709810298453	0.00693140429335888
CHOL	BOLL	CDC25A	-1.60973851948376	0.01171875
LUAD	BOLL	STRA8	-1.41754146083021	0.0167287003897047
LIHC	BOLL	STRA8	-3.87887257303094	0.0170556294065931
READ	BOLL	CDC25A	2.77912682598966	0.03125
LUSC	BOLL	DDX4	-1.95443502746625	0.0421700405387188
KIRC	BOLL	DAZAP2	-1.56944293598429	1.18412369238507e-12
LUAD	BOLL	CDC25A	-2.21079610386558	1.37708156940508e-10
KIRC	BOLL	UBA5	1.02314037381943	1.58030057939183e-06
PRAD	BOLL	CDC25A	-1.48888098360879	1.59682258051075e-07
THCA	BOLL	PUM2	-1.39880758764172	1.87410187143234e-06
LUSC	BOLL	DAZAP2	-6.92156732970652	2.02303326988093e-08
THCA	BOLL	CDC25A	1.35909050322207	2.5764473552472e-05
COAD	BOLL	CDC25A	1.36176967046175	3.18586826324463e-05
LUAD	BOLL	DAZAP2	-2.28151519049082	4.03473265936455e-08
THCA	BOLL	DAZAP2	-2.08154255444966	4.34908705582551e-08
COAD	BOLL	DAZAP2	-2.58964489482129	4.41074371337891e-05
BRCA	BOLL	CDC25A	-4.41600366882679	5.56331467027347e-24
PRAD	BOLL	DAZAP2	-2.47561641884191	6.03094358564729e-05
KIRC	BOLL	CDC20B	-2.44402301546464	6.34341665641393e-06
LIHC	BOLL	CDC25A	-1.61115593723517	6.95667288468821e-09
KIRP	BOLL	DAZAP2	-1.67219145623993	9.4762071967125e-07

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with BOLL

DAZ1, NPBWR2, SERF2, TFG, RBPMS, RBFOX2, C1orf94, HNRNPLL, ZNF385C, UBA5, CDC20B, ACY1, ZBTB32, SEMA3B, FAM168A, PATZ1, PHF1, EHHADH, INO80B, SNRPC, RHOXF2, ZC3H10, HYPK, POGZ, NAF1, C4orf45, RBPMS2, ATXN2L, TCEA2, CBX2, PRR34, FOXD4L1, HYAL3, AGRN, POM121, ARID5A, SYCE1L, KRTAP19-3, DCANP1, RNF166,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
BOLL	LUAD	chr2	198631311	198631311	C	A	Missense_Mutation	p.S178I	3
BOLL	ESCA	chr2	198636637	198636637	T	C	Missense_Mutation	p.H153R	3
BOLL	SKCM	chr2	198641828	198641828	G	A	Silent	p.F89F	3
BOLL	ESCA	chr2	198636638	198636638	G	T	Missense_Mutation	p.H153N	3
BOLL	LIHC	chr2	198641794	198641794	T	-	Frame_Shift_Del	p.I101fs	3
BOLL	HNSC	chr2	198646475	198646475	G	A	Missense_Mutation	p.R46C	3
BOLL	SKCM	chr2	198593232	198593232	C	T	Missense_Mutation	p.D321N	2
BOLL	ESCA	chr2	198636638	198636638	G	T	Missense_Mutation		2
BOLL	STAD	chr2	198641828	198641828	G	A	Silent		2
BOLL	BLCA	chr2	198641782	198641782	C	-	Splice_Site		2
BOLL	STAD	chr2	198643760	198643760	A	-	Frame_Shift_Del	p.S66fs	2
BOLL	COAD	chr2	198641827	198641827	C	T	Missense_Mutation	p.V78I	2
BOLL	SKCM	chr2	198640397	198640397	C	T	Missense_Mutation	p.G127E	2
BOLL	UCEC	chr2	198607850	198607850	G	T	Missense_Mutation	p.H267N	2
BOLL	SARC	chr2	198607837	198607837	G	A	Missense_Mutation	p.A271V	2
BOLL	UCEC	chr2	198631320	198631320	G	A	Missense_Mutation	p.S175F	2
BOLL	HNSC	chr2	198636708	198636708	T	G	Splice_Site		2
BOLL	SARC	chr2	198621169	198621169	C	T	Missense_Mutation	p.E250K	2
BOLL	UCEC	chr2	198636692	198636692	G	A	Missense_Mutation	p.P135S	2
BOLL	SARC	chr2	198621169	198621169	C	T	Missense_Mutation		2
BOLL	UCEC	chr2	198646541	198646541	G	A	Missense_Mutation	p.P24S	2
BOLL	SARC	chr2	198607837	198607837	G	A	Missense_Mutation		2
BOLL	UCEC	chr2	198646556	198646556	A	C	Missense_Mutation	p.S19A	2
BOLL	CESC	chr2	198621238	198621238	C	T	Missense_Mutation		2
BOLL	ESCA	chr2	198650890	198650890	C	T	RNA	NULL	2
BOLL	CESC	chr2	198621173	198621173	C	T	Silent		2
BOLL	ESCA	chr2	198636637	198636637	T	C	Missense_Mutation		2
BOLL	HNSC	chr2	198646521	198646521	C	T	Silent	p.L30L	1
BOLL	THCA	chr2	198640461	198640461	C	G	Missense_Mutation	p.E94Q	1
BOLL	CESC	chr2	198621173	198621173	C	T	Silent	p.L248	1
BOLL	LUAD	chr2	198636675	198636675	C	A	Missense_Mutation	p.M140I	1
BOLL	LUSC	chr2	198640396	198640396	C	T	Silent	p.G121G	1
BOLL	SKCM	chr2	198646462	198646462	C	T	Missense_Mutation	p.G38E	1
BOLL	HNSC	chr2	198636708	198636708	T	G	Splice_Site	p.R118_splice	1
BOLL	SKCM	chr2	198640447	198640447	A	G	Silent	p.Y110Y	1
BOLL	THCA	chr2	198640461	198640461	C	G	Missense_Mutation	p.E106Q	1
BOLL	CESC	chr2	198621238	198621238	C	T	Missense_Mutation	p.E227K	1
BOLL	LUAD	chr2	198641836	198641836	A	C	Splice_Site	p.Y87_splice	1
BOLL	ESCA	chr2	198650819	198650819	T	A	Missense_Mutation		1
BOLL	LUSC	chr2	198631324	198631324	G	T	Missense_Mutation	p.R168S	1
BOLL	SKCM	chr2	198593201	198593201	C	T	Missense_Mutation	p.R331Q	1
BOLL	ACC	chr2	198640394	198640394	A	C	Missense_Mutation	p.I128S	1
BOLL	HNSC	chr2	198646475	198646475	G	A	Missense_Mutation	p.R34C	1
BOLL	UCEC	chr2	198640388	198640388	C	T	Splice_Site	p.R124_splice	1
BOLL	COAD	chr2	198636598	198636598	G	A	Missense_Mutation	p.S154L	1
BOLL	LUAD	chr2	198646540	198646540	G	T	Missense_Mutation	p.P24H	1
BOLL	GBM	chr2	198643759	198643759	G	A	Missense_Mutation	p.S60F	1
BOLL	LUSC	chr2	198646462	198646462	C	G	Missense_Mutation	p.G44A	1
BOLL	SKCM	chr2	198621162	198621162	G	A	Missense_Mutation	p.S252L	1
BOLL	KIRP	chr2	198643755	198643755	C	T	Silent	p.Q67Q	1
BOLL	UCEC	chr2	198607850	198607850	G	T	Missense_Mutation	p.H283N	1
BOLL	LUAD	chr2	198646541	198646541	G	T	Missense_Mutation	p.P24T	1
BOLL	GBM	chr2	198643759	198643759	G	A	Missense_Mutation		1
BOLL	OV	chr2	198631309	198631309	A	C	Missense_Mutation	p.S179A	1
BOLL	BLCA	chr2	198621229	198621229	A	T	Missense_Mutation		1
BOLL	LGG	chr2	198636632	198636632	C	T	Missense_Mutation	p.G155S	1
BOLL	STAD	chr2	198641795	198641795	T	G	Missense_Mutation	p.K100N	1
BOLL	COAD	chr2	198643784	198643784	C	T	Missense_Mutation	p.E46K	1
BOLL	LUAD	chr2	198643703	198643703	T	C	Missense_Mutation	p.K85E	1
BOLL	HNSC	chr2	198621153	198621153	T	G	Missense_Mutation		1
BOLL	OV	chr2	198646522	198646522	A	G	Missense_Mutation	p.L30S	1
BOLL	SKCM	chr2	198593229	198593229	G	A	Missense_Mutation	p.P322S	1
BOLL	BLCA	chr2	198621210	198621210	G	A	Missense_Mutation		1
BOLL	LIHC	chr2	198643716	198643716	T	C	Missense_Mutation		1
BOLL	STAD	chr2	198621225	198621225	T	C	Missense_Mutation	p.Q231R	1
BOLL	COAD	chr2	198646555	198646555	G	A	Missense_Mutation	p.S7F	1
BOLL	PRAD	chr2	198640396	198640396	C	T	Silent	p.G127G	1
BOLL	SKCM	chr2	198646462	198646462	C	T	Missense_Mutation	p.G50E	1
BOLL	BLCA	chr2	198621229	198621229	A	T	Missense_Mutation	p.Y230N	1
BOLL	LIHC	chr2	198621163	198621163	A	G	Missense_Mutation		1
BOLL	STAD	chr2	198622118	198622118	T	C	Missense_Mutation	p.T199A	1
BOLL	LUAD	chr2	198646503	198646503	G	A	Silent	p.A36A	1
BOLL	HNSC	chr2	198646475	198646475	G	A	Missense_Mutation		1
BOLL	BLCA	chr2	198607796	198607796	C	G	Missense_Mutation	p.E273Q	1
BOLL	LIHC	chr2	198621218	198621218	C	A	Silent		1
BOLL	STAD	chr2	198641795	198641795	T	G	Missense_Mutation	p.K88N	1
BOLL	LUAD	chr2	198622102	198622102	C	G	Missense_Mutation	p.G204A	1
BOLL	SARC	chr2	198650830	198650830	C	A	RNA	NULL	1
BOLL	HNSC	chr2	198646521	198646521	C	T	Silent		1
BOLL	SKCM	chr2	198650719	198650719	G	A	Silent	p.T3T	1
BOLL	BLCA	chr2	198621229	198621229	A	T	Missense_Mutation	p.Y218N	1
BOLL	LIHC	chr2	198641827	198641827	C	T	Missense_Mutation	p.V90I	1
BOLL	STAD	chr2	198621225	198621225	T	C	Missense_Mutation	p.Q219R	1
BOLL	ESCA	chr2	198650819	198650819	T	A	RNA	NULL	1
BOLL	LUAD	chr2	198646540	198646541	GG	TT	Missense_Mutation	p.P12N	1
BOLL	SKCM	chr2	198643759	198643759	G	A	Missense_Mutation	p.S54F	1
BOLL	HNSC	chr2	198621153	198621153	T	G	Splice_Site	p.E255_splice	1
BOLL	SARC	chr2	198649959	198649959	G	A	Missense_Mutation		1
BOLL	SKCM	chr2	198643759	198643759	G	A	Missense_Mutation	p.S66F	1
BOLL	STAD	chr2	198622118	198622118	T	C	Missense_Mutation	p.T187A	1
BOLL	LUAD	chr2	198643703	198643703	T	C	Missense_Mutation	p.K73E	1
BOLL	SKCM	chr2	198640447	198640447	A	G	Silent	p.Y98Y	1
BOLL	SARC	chr2	198623700	198623700	A	G	Missense_Mutation		1
BOLL	SKCM	chr2	198621170	198621170	C	T	Missense_Mutation	p.M249I	1
BOLL	THCA	chr2	198640461	198640461	C	G	Missense_Mutation		1
BOLL	LIHC	chr2	198640408	198640408	T	-	Frame_Shift_Del	p.K123fs	1
BOLL	LUAD	chr2	198646503	198646503	G	A	Silent	p.A24A	1
BOLL	SKCM	chr2	198636606	198636606	C	T	Silent	p.E151E	1

Copy number variation (CNV) of BOLL
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across BOLL
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
103282	N/A	EC547956	BOLL	chr2	198629613	-	MYH9	chr22	36677329	+
35382	BLCA	TCGA-GC-A4ZW-01A	GULP1	chr2	189156893	+	BOLL	chr2	198607883	-
35382	BLCA	TCGA-GC-A4ZW-01A	GULP1	chr2	189157839	+	BOLL	chr2	198607883	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	BOLL	0.001140493076317	0.032
BLCA	BOLL	0.0110548317880369	0.3
ESCA	BOLL	0.0422617453240462	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
OV	BOLL	0.014720240458964	0.49
COAD	BOLL	0.0300341077313239	0.96

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0009402	Colorectal Carcinoma	1	CTD_human