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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: ZFP36L2 (NCBI Gene ID:678)

Gene Summary

Gene Summary

Gene Information	Gene Name: ZFP36L2
	Gene ID: 678
	Gene Symbol	ZFP36L2
	Gene ID	678
	Gene Name	ZFP36 ring finger protein like 2
	Synonyms	BRF2\|ERF-2\|ERF2\|RNF162C\|TIS11D
	Cytomap	2p21
	Type of Gene	protein-coding
	Description	mRNA decay activator protein ZFP36L2EGF-response factor 2TPA-induced sequence 11dZFP36-like 2butyrate response factor 2zinc finger protein 36, C3H type-like 1zinc finger protein 36, C3H type-like 2zinc finger protein 36, C3H1 type-like 2zinc finge
	Modification date	20200313
	UniProtAcc	P47974

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ZFP36L2	GO:0009611	response to wounding	27182009
Hgene	ZFP36L2	GO:0044344	cellular response to fibroblast growth factor stimulus	20166898
Hgene	ZFP36L2	GO:0070371	ERK1 and ERK2 cascade	25106868
Hgene	ZFP36L2	GO:0071356	cellular response to tumor necrosis factor	20166898
Hgene	ZFP36L2	GO:0071364	cellular response to epidermal growth factor stimulus	20166898
Hgene	ZFP36L2	GO:0071385	cellular response to glucocorticoid stimulus	20166898
Hgene	ZFP36L2	GO:0071560	cellular response to transforming growth factor beta stimulus	20166898
Hgene	ZFP36L2	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus	20166898

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
ZFP36L2	(355.7 - 733]

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Translation Studies in PubMed

We searched PubMed using 'ZFP36L2[title] AND translation [title] AND human.'

Gene	Title	PMID
ZFP36L2	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
BLCA	ZFP36L2	-3.33113082677763	0.002838134765625
UCEC	ZFP36L2	-5.23753532672916	0.03125
THCA	ZFP36L2	-1.77503449609117	1.26054437009301e-09

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
HNSC	ZFP36L2	3	2	0.0157966779562299	0.619072899159664	0.495905515732048	-0.109682569598818	0.122704014874902

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
MESO	ZFP36L2	-0.044142202	0.036198027
LAML	ZFP36L2	0.017063806	0.0418886
CESC	ZFP36L2	-0.027210767	0.049208031

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with ZFP36L2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	TSG	ZFP36L2	TXNIP	0.812046894	2.48E-12

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
STAD	ZFP36L2	BRF1	-2.0889592694215	0.000133869703859091
THCA	ZFP36L2	RAP1GDS1	-1.10586439664627	0.000331869180527397
LIHC	ZFP36L2	ZDHHC9	1.17134045538249	0.00103031667689717
KIRP	ZFP36L2	RAP1GDS1	1.5813279692516	0.00239070039242506
BLCA	ZFP36L2	ZFP36L1	-1.30144233560444	0.00239944458007812
COAD	ZFP36L2	MAPKAPK2	-1.81020927366109	0.00266072154045105
CHOL	ZFP36L2	GOLGA7	1.95255356107908	0.00390625
KIRC	ZFP36L2	ZFP36L1	-1.52194341523333	0.00581299889093125
PRAD	ZFP36L2	GOLGA7	1.07910795828743	0.00793869166548181
THCA	ZFP36L2	ZFP36L1	2.55468789332241	1.72307312615607e-07
BRCA	ZFP36L2	ZFP36L1	-2.18127566509241	3.19437614469675e-17
STAD	ZFP36L2	ZFP36L1	-1.77370885839222	3.94955277442932e-05
BLCA	ZFP36L2	ZDHHC9	-2.74292940819368	7.62939453125e-06

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with ZFP36L2

CUL3, YWHAE, YWHAB, XPO1, GEMIN5, SMC6, Akt2, HIF1AN, CBY1, TRIM14, ESR2, ZYG11B, AKR1C2, ARSK, ATP2C1, ATP5B, BANF1, BASP1, BRD3, BRSK1, C1QBP, C1R, C3, CAMK2A, CAPRIN1, CARS2, CCAR2, CCT6A, CENPQ, CFL1, CHM, CMYA5, CSN2, CTNNA1, DDX20, DDX5, DGCR2, DHX40, DLD, DLST, EEF2, EIF3F, EIF3G, EIF3H, EIF3M, EIF4B, ENO1, EZR, FAM160B1, FAM57B, FBXO11, SBNO1, ZNF18, FLOT1, FYTTD1, G3BP1, GAPDH, GAS1, GPI, HADHA, HEXDC, HNRNPA2B1, HNRNPAB, HNRNPDL, HNRNPK, HNRNPL, HNRNPM, HNRNPU, HSP90AA1, HSPA8, HSPA9, HSPD1, HSPE1, IGHG1, IRF6, ITGB3, IVNS1ABP, IGJ, KHDRBS1, LCTL, LDHA, LDHB, PPIA, OGFR, LRPPRC, LRRC9, LTF, MAB21L1, MDH2, MED16, MGA, MGC15885, MIF, MRPL12, MRPS36, MYBBP1A, MYCBP, MYL6, NCL, NEDD4, NME1, NONO, NPM1, OGDH, OTUD4, PABPC1, PADI1, PCDHA4, PCID2, PFN1, PGD, PLCH2, PLS3, POLR2G, PPIB, PRDX1, PRMT5, PROCA1, PRPS1, PRPS2, PRPSAP1, PRPSAP2, PRSS1, PRSS3, PTBP1, PTPRS, PZP, RAB39A, RBM10, RBMY1C, REL, RNF219, RPL11, RPL15, RPL22, RPL35, RPLP1, RPLP2, RPS10, RPS11, RPS13, RPS15, RPS16, RPS18, RPS19, RPS24, UBC, RPS3, RPS3A, RPS4X, RPS5, RPS7, S100A16, S100A6, SETBP1, SFPQ, SIK3, SIX1, SLC38A10, SLIRP, SPTBN1, SPTBN5, STK38, STRAP, SUPT16H, SYNCRIP, TAGLN2, TENM1, TET1, THRAP3, TKT, TMPO, TOP1MT, TPI1, TPPP, TPT1P8, TRAPPC9, TRIM21, TRIM31, TRIM47, TTK, TUBA1B, TUBB, TXN, UACA, UBR3, UNC45B, USP9Y, YBX1, YWHAG, YWHAH, YWHAQ, YWHAZ, ZFYVE21, ZNF333, ZNF34, ZRANB2, N, ESR1, PUM1, MOV10, FASN, C12orf49, SQSTM1, FAM120A, LAD1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
ZFP36L2	chr2	43451516	C	CT	Duplication	not_provided	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
ZFP36L2	COAD	chr2	43452512	43452512	C	-	Frame_Shift_Del	p.G144fs	4
ZFP36L2	COAD	chr2	43452623	43452623	C	-	Frame_Shift_Del	p.G107fs	4
ZFP36L2	BLCA	chr2	43451740	43451742	CTG	-	In_Frame_Del	p.Q401del	4
ZFP36L2	BLCA	chr2	43452474	43452474	C	T	Missense_Mutation	p.E157K	4
ZFP36L2	BLCA	chr2	43452225	43452225	C	T	Missense_Mutation	p.D240N	3
ZFP36L2	BRCA	chr2	43452567	43452567	C	G	Missense_Mutation	p.E126Q	3
ZFP36L2	HNSC	chr2	43452511	43452512	-	C	Frame_Shift_Ins	p.G144fs	3
ZFP36L2	BRCA	chr2	43453450	43453450	G	C	Missense_Mutation	p.S2W	3
ZFP36L2	COAD	chr2	43452622	43452623	-	C	Frame_Shift_Ins	p.G107fs	3
ZFP36L2	PAAD	chr2	43451467	43451467	G	A	Silent	p.S492S	3
ZFP36L2	BLCA	chr2	43452225	43452225	C	G	Missense_Mutation	p.D240H	3
ZFP36L2	UCS	chr2	43452192	43452192	G	A	Missense_Mutation	p.R251W	3
ZFP36L2	UCS	chr2	43452260	43452260	C	-	Frame_Shift_Del	p.G228fs	3
ZFP36L2	LIHC	chr2	43452474	43452474	C	G	Missense_Mutation	p.E157Q	3
ZFP36L2	UCS	chr2	43451501	43451501	C	T	Missense_Mutation	p.R481H	3
ZFP36L2	UCEC	chr2	43452639	43452640	-	A	Frame_Shift_Ins	p.K101fs	2
ZFP36L2	BLCA	chr2	43452198	43452198	C	G	Missense_Mutation	p.E249Q	2
ZFP36L2	HNSC	chr2	43451806	43451806	C	T	Silent	p.Q379Q	2
ZFP36L2	BRCA	chr2	43453434	43453434	G	A	Silent	p.S7	2
ZFP36L2	KIRC	chr2	43452170	43452170	A	G	Missense_Mutation	p.L258P	2
ZFP36L2	UCEC	chr2	43452645	43452645	T	C	Missense_Mutation	p.T100A	2
ZFP36L2	CESC	chr2	43452364	43452364	C	G	Missense_Mutation		2
ZFP36L2	READ	chr2	43452464	43452465	-	G	Frame_Shift_Ins	p.R160fs	2
ZFP36L2	STAD	chr2	43452297	43452297	G	A	Missense_Mutation	p.H216Y	2
ZFP36L2	UCEC	chr2	43452828	43452829	-	CGTCC	Frame_Shift_Ins	p.P38fs	2
ZFP36L2	STAD	chr2	43452440	43452440	C	T	Missense_Mutation	p.C168Y	2
ZFP36L2	UCEC	chr2	43453431	43453431	G	T	Silent	p.A8	2
ZFP36L2	STAD	chr2	43452855	43452855	T	C	Missense_Mutation	p.M30V	2
ZFP36L2	BRCA	chr2	43452183	43452183	A	G	Silent	p.L254	2
ZFP36L2	THCA	chr2	43452123	43452123	G	A	Missense_Mutation	p.L274F	2
ZFP36L2	CESC	chr2	43452373	43452373	C	T	Silent		2
ZFP36L2	BLCA	chr2	43452474	43452474	C	T	Missense_Mutation		2
ZFP36L2	PAAD	chr2	43453409	43453409	A	G	Missense_Mutation	p.C16R	2
ZFP36L2	PAAD	chr2	43452623	43452623	C	-	Frame_Shift_Del	p.G109fs	2
ZFP36L2	BLCA	chr2	43452553	43452554	-	C	Frame_Shift_Ins	p.R130fs	2
ZFP36L2	HNSC	chr2	43451842	43451842	C	A	Silent	p.P367P	2
ZFP36L2	BLCA	chr2	43452168	43452168	T	C	Missense_Mutation	p.S259G	2
ZFP36L2	SKCM	chr2	43452023	43452023	G	A	Missense_Mutation	p.S307F	2
ZFP36L2	CESC	chr2	43452399	43452399	C	T	Missense_Mutation		2
ZFP36L2	HNSC	chr2	43452530	43452530	T	A	Missense_Mutation	p.Q138L	2
ZFP36L2	BLCA	chr2	43452318	43452318	C	T	Missense_Mutation	p.G209R	2
ZFP36L2	KIRC	chr2	43452470	43452470	A	G	Missense_Mutation	p.L158P	2
ZFP36L2	ESCA	chr2	43452439	43452440	-	CA	Frame_Shift_Ins	p.C168fs	2
ZFP36L2	UCEC	chr2	43452495	43452496	-	G	Frame_Shift_Ins	p.N149fs	2
ZFP36L2	BLCA	chr2	43452478	43452478	C	G	Missense_Mutation	p.K155N	2
ZFP36L2	HNSC	chr2	43452849	43452849	C	T	Missense_Mutation	p.D32N	2
ZFP36L2	BLCA	chr2	43452198	43452198	C	T	Missense_Mutation	p.E249K	2
ZFP36L2	BLCA	chr2	43452225	43452225	C	G	Missense_Mutation		2
ZFP36L2	BLCA	chr2	43452831	43452832	-	C	Frame_Shift_Ins	p.G37fs	2
ZFP36L2	ESCA	chr2	43452439	43452440	-	CA	Frame_Shift_Ins	p.*168fs	1
ZFP36L2	LUSC	chr2	43452044	43452044	G	C	Missense_Mutation	p.S300C	1
ZFP36L2	CESC	chr2	43453424	43453424	C	T	Missense_Mutation		1
ZFP36L2	READ	chr2	43452244	43452245	-	A	Frame_Shift_Ins	p.L233fs	1
ZFP36L2	COAD	chr2	43452501	43452501	G	A	Nonsense_Mutation	p.Q148X	1
ZFP36L2	STAD	chr2	43452037	43452039	GGA	-	In_Frame_Del	p.S302del	1
ZFP36L2	BLCA	chr2	43451824	43451824	G	A	Silent		1
ZFP36L2	HNSC	chr2	43452464	43452465	-	-	Frame_Shift_Ins		1
ZFP36L2	LUSC	chr2	43452461	43452461	G	C	Missense_Mutation	p.P161R	1
ZFP36L2	BLCA	chr2	43452288	43452288	C	A	Missense_Mutation	p.D219Y	1
ZFP36L2	HNSC	chr2	43452233	43452234	-	CA	Frame_Shift_Ins	p.H237fs	1
ZFP36L2	BLCA	chr2	43452198	43452198	C	A	Nonsense_Mutation	p.E249*	1
ZFP36L2	STAD	chr2	43452465	43452466	-	G	Frame_Shift_Ins	p.R160fs	1
ZFP36L2	BLCA	chr2	43452168	43452168	T	C	Missense_Mutation		1
ZFP36L2	KIRP	chr2	43452438	43452438	T	C	Missense_Mutation	p.K169E	1
ZFP36L2	HNSC	chr2	43452301	43452302	-	-	Frame_Shift_Ins		1
ZFP36L2	LUSC	chr2	43452889	43452889	T	A	Silent	p.T18T	1
ZFP36L2	BLCA	chr2	43452289	43452289	C	A	Silent	p.A218A	1
ZFP36L2	CESC	chr2	43452364	43452364	C	G	Missense_Mutation	p.K193N	1
ZFP36L2	BLCA	chr2	43452456	43452456	C	T	Missense_Mutation	p.E163K	1
ZFP36L2	COAD	chr2	43452532	43452533	-	A	Frame_Shift_Ins	p.L137fs	1
ZFP36L2	READ	chr2	43452581	43452582	-	C	Frame_Shift_Ins	p.D121fs	1
ZFP36L2	STAD	chr2	43452623	43452624	-	C	Frame_Shift_Ins	p.G107fs	1
ZFP36L2	BLCA	chr2	43452553	43452554	-	-	Frame_Shift_Ins		1
ZFP36L2	KIRP	chr2	43451900	43451925	GCCCCCGGCGCCAGCAGGTCCTCGGC	-	Frame_Shift_Del	p.340_348del	1
ZFP36L2	HNSC	chr2	43452511	43452512	-	-	Frame_Shift_Ins		1
ZFP36L2	PAAD	chr2	43451467	43451467	G	A	Silent		1
ZFP36L2	BLCA	chr2	43452269	43452269	G	T	Missense_Mutation	p.P225Q	1
ZFP36L2	CESC	chr2	43452399	43452399	C	T	Missense_Mutation	p.E182K	1
ZFP36L2	BLCA	chr2	43452313	43452313	C	T	Silent	p.P210P	1
ZFP36L2	HNSC	chr2	43452301	43452302	-	T	Frame_Shift_Ins	p.Y214fs	1
ZFP36L2	SKCM	chr2	43451460	43451460	A	T	Missense_Mutation	p.X495R	1
ZFP36L2	THCA	chr2	43452183	43452183	A	G	Silent		1
ZFP36L2	BLCA	chr2	43452318	43452318	C	T	Missense_Mutation		1
ZFP36L2	KIRP	chr2	43452183	43452183	A	G	Silent	p.L254L	1
ZFP36L2	HNSC	chr2	43452849	43452849	C	T	Missense_Mutation		1
ZFP36L2	PAAD	chr2	43451739	43451740	-	CTGCTG	In_Frame_Ins	p.G402delinsQQG	1
ZFP36L2	UCS	chr2	43452192	43452192	G	A	Missense_Mutation		1
ZFP36L2	BLCA	chr2	43452248	43452248	T	A	Missense_Mutation	p.D232V	1
ZFP36L2	CESC	chr2	43452529	43452529	C	T	Silent	p.Q138	1
ZFP36L2	BLCA	chr2	43452597	43452597	C	A	Nonsense_Mutation	p.E116*	1
ZFP36L2	HNSC	chr2	43452555	43452556	-	A	Frame_Shift_Ins	p.EQ129fs	1
ZFP36L2	SKCM	chr2	43452068	43452068	G	A	Missense_Mutation	p.S292F	1
ZFP36L2	STAD	chr2	43452037	43452039	GGA	-	In_Frame_Del	p.302_303del	1
ZFP36L2	BLCA	chr2	43452198	43452198	C	T	Missense_Mutation		1
ZFP36L2	COAD	chr2	43452635	43452636	-	C	Frame_Shift_Ins	p.E103fs	1
ZFP36L2	KIRP	chr2	43451957	43451957	G	A	Missense_Mutation	p.A329V	1
ZFP36L2	HNSC	chr2	43451842	43451842	C	A	Silent		1
ZFP36L2	UCS	chr2	43452260	43452260	C	-	Frame_Shift_Del		1
ZFP36L2	CESC	chr2	43452542	43452542	A	T	Missense_Mutation	p.L134H	1
ZFP36L2	BLCA	chr2	43451879	43451879	G	A	Missense_Mutation	p.S355L	1
ZFP36L2	HNSC	chr2	43452544	43452545	-	T	Frame_Shift_Ins	p.P133fs	1
ZFP36L2	SKCM	chr2	43451460	43451460	A	T	Nonstop_Mutation	p.*495R	1
ZFP36L2	STAD	chr2	43452885	43452886	TC	-	Frame_Shift_Del	p.20_20del	1
ZFP36L2	COAD	chr2	43452637	43452638	-	T	Frame_Shift_Ins	p.K102fs	1
ZFP36L2	LIHC	chr2	43451848	43451848	G	A	Silent	p.F365F	1
ZFP36L2	UCEC	chr2	43452341	43452341	T	G	Missense_Mutation	p.H201P	1
ZFP36L2	BLCA	chr2	43452313	43452313	C	T	Silent		1
ZFP36L2	CESC	chr2	43452886	43452886	C	G	Missense_Mutation		1
ZFP36L2	HNSC	chr2	43452544	43452545	-	-	Frame_Shift_Ins		1
ZFP36L2	BLCA	chr2	43451536	43451536	G	A	Silent	p.L469L	1
ZFP36L2	CESC	chr2	43452806	43452806	G	A	Missense_Mutation	p.S46L	1
ZFP36L2	STAD	chr2	43452657	43452657	T	C	Missense_Mutation	p.T96A	1
ZFP36L2	BLCA	chr2	43452478	43452478	C	G	Missense_Mutation		1
ZFP36L2	HNSC	chr2	43452464	43452465	-	G	Frame_Shift_Ins	p.A160fs	1
ZFP36L2	SKCM	chr2	43452266	43452266	G	A	Missense_Mutation	p.S226L	1
ZFP36L2	COAD	chr2	43452679	43452679	G	A	Silent	p.G88G	1
ZFP36L2	LIHC	chr2	43452453	43452453	C	A	Nonsense_Mutation	p.E164X	1
ZFP36L2	UCEC	chr2	43452639	43452640	-	A	Frame_Shift_Ins	p.L101fs	1
ZFP36L2	BLCA	chr2	43452456	43452456	C	T	Missense_Mutation		1
ZFP36L2	CESC	chr2	43452542	43452542	A	T	Missense_Mutation		1
ZFP36L2	HNSC	chr2	43452555	43452556	-	-	Frame_Shift_Ins		1
ZFP36L2	BLCA	chr2	43451824	43451824	G	A	Silent	p.I373I	1
ZFP36L2	CESC	chr2	43452886	43452886	C	G	Missense_Mutation	p.E19D	1
ZFP36L2	STAD	chr2	43453416	43453416	G	A	Silent	p.D13D	1
ZFP36L2	BLCA	chr2	43452288	43452288	C	A	Missense_Mutation		1
ZFP36L2	HNSC	chr2	43452301	43452302	-	T	Frame_Shift_Ins	p.F214fs	1
ZFP36L2	SKCM	chr2	43452482	43452482	T	A	Missense_Mutation	p.Y154F	1
ZFP36L2	COAD	chr2	43452682	43452682	G	-	Frame_Shift_Del	p.G88fs	1
ZFP36L2	UCEC	chr2	43452495	43452496	-	G	Frame_Shift_Ins	p.I149fs	1
ZFP36L2	BLCA	chr2	43452575	43452575	G	A	Missense_Mutation		1
ZFP36L2	CESC	chr2	43452529	43452529	C	T	Silent		1
ZFP36L2	PRAD	chr2	43452332	43452332	C	T	Missense_Mutation	p.G204D	1
ZFP36L2	CESC	chr2	43452373	43452373	C	T	Silent	p.P190	1
ZFP36L2	STAD	chr2	43452840	43452840	C	T	Missense_Mutation	p.A35T	1
ZFP36L2	BLCA	chr2	43452289	43452289	C	A	Silent		1
ZFP36L2	BLCA	chr2	43452831	43452832	-	C	Frame_Shift_Ins	p.T38fs	1
ZFP36L2	HNSC	chr2	43452544	43452545	-	T	Frame_Shift_Ins	p.H133fs	1
ZFP36L2	ESCA	chr2	43452439	43452440	-	CA	Frame_Shift_Ins	p.K169fs	1
ZFP36L2	LUAD	chr2	43452607	43452607	C	T	Silent	p.L112L	1
ZFP36L2	UCEC	chr2	43451953	43451969	CGCAGCCGCGGCCGCCG	-	Frame_Shift_Del	p.A325fs	1
ZFP36L2	PRAD	chr2	43452136	43452136	C	T	Silent	p.Q269Q	1
ZFP36L2	COAD	chr2	43451493	43451493	G	A	Missense_Mutation	p.P484S	1
ZFP36L2	STAD	chr2	43452232	43452232	G	C	Silent	p.G237G	1
ZFP36L2	BLCA	chr2	43452248	43452248	T	A	Missense_Mutation		1
ZFP36L2	BLCA	chr2	43451901	43451901	C	-	Frame_Shift_Del	p.A348fs	1
ZFP36L2	SKCM	chr2	43452413	43452426	GCGAACTGGCACTT	-	Frame_Shift_Del	p.KCQFA173fs	1
ZFP36L2	LUAD	chr2	43452831	43452832	-	C	Frame_Shift_Ins	p.A38fs	1
ZFP36L2	CESC	chr2	43452334	43452334	G	A	Silent		1
ZFP36L2	PRAD	chr2	43452646	43452647	-	C	Frame_Shift_Ins	p.D99fs	1
ZFP36L2	COAD	chr2	43452491	43452492	-	T	Frame_Shift_Ins	p.S151fs	1
ZFP36L2	STAD	chr2	43452885	43452886	TC	-	Frame_Shift_Del	p.E19fs	1
ZFP36L2	KIRC	chr2	43452740	43452740	G	A	Missense_Mutation	p.A68V	1
ZFP36L2	STAD	chr2	43452623	43452623	C	-	Frame_Shift_Del		1

Copy number variation (CNV) of ZFP36L2
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across ZFP36L2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
95759	N/A	AX379239	AKAP8L	chr19	15510348	+	ZFP36L2	chr2	43449726	+
95759	N/A	N67537	CTC-347C20.1	chr5	72046090	-	ZFP36L2	chr2	43449541	+
95759	N/A	BI491349	DLG1	chr3	196807332	+	ZFP36L2	chr2	43449541	+
95759	BRCA	TCGA-D8-A1XT-01A	GAREM	chr18	29847450	-	ZFP36L2	chr2	43451029	-
95759	N/A	CB050158	KCNQ3	chr8	133393178	-	ZFP36L2	chr2	43451182	+
95759	N/A	BM728873	NFYA	chr6	41040799	+	ZFP36L2	chr2	43452140	-
95759	N/A	BM995008	S100A11	chr1	152005157	+	ZFP36L2	chr2	43450007	+
95759	N/A	AW993390	SOX11	chr2	5840532	+	ZFP36L2	chr2	43450254	-
95759	N/A	AI650588	U2AF2	chr19	56170650	+	ZFP36L2	chr2	43451623	-
101055	COAD	TCGA-AZ-6607-01A	ZFP36L2	chr8	37706114	-	C8orf86	chr8	38370157	-
101055	N/A	BE836894	ZFP36L2	chr2	43449549	-	GPC5	chr13	92666177	-
101055	N/A	BG271954	ZFP36L2	chr2	43451353	+	RPL36	chr19	5691411	-
101055	N/A	AW080228	ZFP36L2	chr2	43449782	+	SLAIN2	chr4	48425613	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
SARC	ZFP36L2	0.0029010240904573	0.081
TGCT	ZFP36L2	0.00386261051320637	0.1
BRCA	ZFP36L2	0.00551445655022657	0.14
LUAD	ZFP36L2	0.0178825558022221	0.45
LGG	ZFP36L2	0.0214925914045014	0.52

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	ZFP36L2	0.000148640316239834	0.0048
THCA	ZFP36L2	0.034292218821369	0.99
LAML	ZFP36L2	0.022585731650875	0.68
BRCA	ZFP36L2	8.79283529383641e-06	0.00029
ESCA	ZFP36L2	0.0128197389463697	0.4
THYM	ZFP36L2	0.0468019940683807	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0009402	Colorectal Carcinoma	1	CTD_human
C0376358	Malignant neoplasm of prostate	1	CTD_human
C1961099	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	1	CTD_human