Home

Download

Statistics

Examples

Help

Contact

	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: TIA1 (NCBI Gene ID:7072)

Gene Summary

Gene Summary

Gene Information	Gene Name: TIA1
	Gene ID: 7072
	Gene Symbol	TIA1
	Gene ID	7072
	Gene Name	TIA1 cytotoxic granule associated RNA binding protein
	Synonyms	TIA-1\|WDM
	Cytomap	2p13.3
	Type of Gene	protein-coding
	Description	nucleolysin TIA-1 isoform p40nucleolysin TIA-1T-cell-restricted intracellular antigen-1p40-TIA-1 (containing p15-TIA-1)
	Modification date	20200313
	UniProtAcc	P31483

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TIA1	GO:0048024	regulation of mRNA splicing, via spliceosome	11106748

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
TIA1	>1119.25

Top

Translation Studies in PubMed

We searched PubMed using 'TIA1[title] AND translation [title] AND human.'

Gene	Title	PMID
TIA1	Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells	28904350

Top

Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000433529	70456190	70456223	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000433529	70456190	70456223	4664	489	521	386	92	103

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P31483	92	103	1	386	Chain	ID=PRO_0000031031;Note=Nucleolysin TIA-1 isoform p40
P31483	92	103	93	104	Alternative sequence	ID=VSP_005892;Note=In isoform Short. SSTVVSTQRSQD->N;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:1934064;Dbxref=PMID:1934064

Top

Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUSC	TIA1	-7.74840540416154	0.000209558356255901
LUAD	TIA1	-1.21695463712876	0.0252511614440066
KICH	TIA1	1.65667515704362	8.16583633422851e-06

Top

Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
OV	TIA1	hsa-miR-30e-5p	92	-0.30239904379749	0.0297393780060403

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LIHC	TIA1	0.025886609	0.039820326

Top

Associated Genes

Strongly correlated genes belong to cellular important gene groups with TIA1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	TF	TIA1	ZNF26	0.841446073	4.55E-13
CHOL	TF	TIA1	ZNF84	0.854757704	7.95E-14
DLBC	Cell metabolism gene	TIA1	SIN3B	0.80607856	4.76E-12
DLBC	CGC	TIA1	PWWP2A	0.866401718	1.79E-15
DLBC	Epifactor	TIA1	SIN3B	0.80607856	4.76E-12
DLBC	IUPHAR	TIA1	CLK4	0.807672329	4.01E-12
DLBC	IUPHAR	TIA1	PKN2	0.819686738	1.04E-12
DLBC	IUPHAR	TIA1	SENP7	0.819879519	1.02E-12
DLBC	Kinase	TIA1	CLK4	0.807672329	4.01E-12
DLBC	Kinase	TIA1	PAN3	0.817470066	1.35E-12
DLBC	Kinase	TIA1	PKN2	0.819686738	1.04E-12
KIRP	Cell metabolism gene	TIA1	CSAD	0.858813178	2.94E-95
KIRP	CGC	TIA1	MDM4	0.843258969	1.50E-88
KIRP	Epifactor	TIA1	CDK3	0.839894781	3.39E-87
KIRP	IUPHAR	TIA1	CLK4	0.807559484	1.36E-75
KIRP	IUPHAR	TIA1	GABBR1	0.807975006	9.97E-76
KIRP	IUPHAR	TIA1	CDK3	0.839894781	3.39E-87
KIRP	IUPHAR	TIA1	CLK1	0.844885957	3.23E-89
KIRP	Kinase	TIA1	CLK4	0.807559484	1.36E-75
KIRP	Kinase	TIA1	CDK3	0.839894781	3.39E-87
KIRP	Kinase	TIA1	CLK1	0.844885957	3.23E-89
KIRP	TF	TIA1	CREBZF	0.801346415	1.29E-73
KIRP	TF	TIA1	ZMAT1	0.802469869	5.74E-74
KIRP	TF	TIA1	ZNF23	0.812222068	3.99E-77
KIRP	TF	TIA1	ZNF83	0.822256331	1.42E-80
KIRP	TF	TIA1	ZNF337	0.822411246	1.25E-80
KIRP	TF	TIA1	ZNF789	0.829717638	2.78E-83
KIRP	TF	TIA1	ZNF700	0.833402804	1.14E-84
KIRP	TF	TIA1	DMTF1	0.871318923	2.91E-101
KIRP	TSG	TIA1	RBM5	0.845580336	1.67E-89
KIRP	TSG	TIA1	DMTF1	0.871318923	2.91E-101
LAML	CGC	TIA1	GOPC	0.806668964	6.59E-41
LAML	TF	TIA1	ZNF248	0.828846616	5.44E-45
LGG	TF	TIA1	CREBZF	0.808993259	6.20E-124
SKCM	CGC	TIA1	PMS1	0.806097132	1.31E-109
SKCM	CGC	TIA1	CREB1	0.830870976	3.10E-122
SKCM	CGC	TIA1	SF3B1	0.851350617	2.47E-134
SKCM	Epifactor	TIA1	SMEK2	0.807225204	3.84E-110
SKCM	Epifactor	TIA1	SF3B1	0.851350617	2.47E-134
SKCM	Epifactor	TIA1	ATAD2B	0.852048941	8.87E-135
SKCM	IUPHAR	TIA1	SENP7	0.82107803	5.20E-117
SKCM	IUPHAR	TIA1	ATAD2B	0.852048941	8.87E-135
SKCM	TF	TIA1	ZNF518A	0.811133224	5.06E-112
SKCM	TF	TIA1	SP3	0.816217182	1.56E-114
SKCM	TF	TIA1	CREB1	0.830870976	3.10E-122
THCA	Epifactor	TIA1	PCGF3	0.806557085	3.07E-132
THYM	CGC	TIA1	CBFB	0.808526331	2.08E-29
THYM	CGC	TIA1	MDM4	0.815429117	2.86E-30
THYM	Epifactor	TIA1	CHD1	0.804941286	5.64E-29
THYM	Epifactor	TIA1	SMEK1	0.805744356	4.52E-29
THYM	Epifactor	TIA1	MTF2	0.814042012	4.29E-30
THYM	Epifactor	TIA1	UHRF2	0.825150211	1.52E-31
THYM	Epifactor	TIA1	SUPT7L	0.848215609	6.46E-35
THYM	IUPHAR	TIA1	CLK1	0.802668561	1.05E-28
THYM	Kinase	TIA1	CLK1	0.802668561	1.05E-28
THYM	Kinase	TIA1	PAN3	0.809978789	1.38E-29
THYM	TF	TIA1	ZNF107	0.802085273	1.23E-28
THYM	TF	TIA1	ZBTB2	0.804678859	6.07E-29
THYM	TF	TIA1	ZBED5	0.805205715	5.25E-29
THYM	TF	TIA1	MTF2	0.814042012	4.29E-30
THYM	TF	TIA1	CGGBP1	0.81600299	2.42E-30
THYM	TF	TIA1	ZNF131	0.820169484	6.99E-31
THYM	TF	TIA1	ZNF280D	0.827547421	7.15E-32
THYM	TSG	TIA1	CHD1	0.804941286	5.64E-29
THYM	TSG	TIA1	UHRF2	0.825150211	1.52E-31
UCS	CGC	TIA1	CBFB	0.808526331	2.08E-29
UCS	CGC	TIA1	MDM4	0.815429117	2.86E-30
UCS	Epifactor	TIA1	CHD1	0.804941286	5.64E-29
UCS	Epifactor	TIA1	SMEK1	0.805744356	4.52E-29
UCS	Epifactor	TIA1	MTF2	0.814042012	4.29E-30
UCS	Epifactor	TIA1	UHRF2	0.825150211	1.52E-31
UCS	Epifactor	TIA1	SUPT7L	0.848215609	6.46E-35
UCS	IUPHAR	TIA1	CLK1	0.802668561	1.05E-28
UCS	Kinase	TIA1	CLK1	0.802668561	1.05E-28
UCS	Kinase	TIA1	PAN3	0.809978789	1.38E-29
UCS	TF	TIA1	ZNF107	0.802085273	1.23E-28
UCS	TF	TIA1	ZBTB2	0.804678859	6.07E-29
UCS	TF	TIA1	ZBED5	0.805205715	5.25E-29
UCS	TF	TIA1	MTF2	0.814042012	4.29E-30
UCS	TF	TIA1	CGGBP1	0.81600299	2.42E-30
UCS	TF	TIA1	ZNF131	0.820169484	6.99E-31
UCS	TF	TIA1	ZNF280D	0.827547421	7.15E-32
UCS	TSG	TIA1	CHD1	0.804941286	5.64E-29
UCS	TSG	TIA1	UHRF2	0.825150211	1.52E-31
UVM	Cell metabolism gene	TIA1	COL4A3BP	0.801990431	3.91E-19
UVM	Cell metabolism gene	TIA1	GLS	0.803999981	2.74E-19
UVM	Cell metabolism gene	TIA1	FPGT	0.804262	2.61E-19
UVM	Cell metabolism gene	TIA1	ENOPH1	0.804998633	2.29E-19
UVM	Cell metabolism gene	TIA1	SACM1L	0.805627906	2.05E-19
UVM	Cell metabolism gene	TIA1	SPCS3	0.806346886	1.80E-19
UVM	Cell metabolism gene	TIA1	AKAP5	0.806540925	1.73E-19
UVM	Cell metabolism gene	TIA1	ACSL4	0.807194987	1.54E-19
UVM	Cell metabolism gene	TIA1	MED7	0.809510373	1.01E-19
UVM	Cell metabolism gene	TIA1	NUP107	0.810937293	7.74E-20
UVM	Cell metabolism gene	TIA1	CSGALNACT2	0.811875324	6.50E-20
UVM	Cell metabolism gene	TIA1	AMY2B	0.812284895	6.02E-20
UVM	Cell metabolism gene	TIA1	TNPO1	0.814137789	4.24E-20
UVM	Cell metabolism gene	TIA1	AGPS	0.814236906	4.16E-20
UVM	Cell metabolism gene	TIA1	TRMT11	0.816646814	2.63E-20
UVM	Cell metabolism gene	TIA1	PSMD14	0.816852104	2.53E-20
UVM	Cell metabolism gene	TIA1	SMG1	0.817310082	2.31E-20
UVM	Cell metabolism gene	TIA1	ACADSB	0.819528127	1.50E-20
UVM	Cell metabolism gene	TIA1	NUDT12	0.820156286	1.33E-20
UVM	Cell metabolism gene	TIA1	TRDMT1	0.820973386	1.13E-20
UVM	Cell metabolism gene	TIA1	PPP1CB	0.822335221	8.63E-21
UVM	Cell metabolism gene	TIA1	PIKFYVE	0.82289719	7.71E-21
UVM	Cell metabolism gene	TIA1	LCLAT1	0.823322514	7.08E-21
UVM	Cell metabolism gene	TIA1	MED17	0.824413108	5.69E-21
UVM	Cell metabolism gene	TIA1	DIS3	0.830603071	1.59E-21
UVM	Cell metabolism gene	TIA1	AGL	0.834693028	6.65E-22
UVM	Cell metabolism gene	TIA1	PLA2G12A	0.837434593	3.66E-22
UVM	Cell metabolism gene	TIA1	GNPDA2	0.838589549	2.84E-22
UVM	Cell metabolism gene	TIA1	PNPLA8	0.838740725	2.74E-22
UVM	Cell metabolism gene	TIA1	MED4	0.839544105	2.29E-22
UVM	Cell metabolism gene	TIA1	RANBP2	0.842193532	1.26E-22
UVM	Cell metabolism gene	TIA1	NUP50	0.842252204	1.25E-22
UVM	Cell metabolism gene	TIA1	DBT	0.842953993	1.06E-22
UVM	Cell metabolism gene	TIA1	NUPL2	0.843868291	8.62E-23
UVM	Cell metabolism gene	TIA1	NAMPT	0.848668262	2.81E-23
UVM	Cell metabolism gene	TIA1	DCK	0.849316024	2.41E-23
UVM	Cell metabolism gene	TIA1	FBXW7	0.849719569	2.19E-23
UVM	Cell metabolism gene	TIA1	NUPL1	0.849871183	2.11E-23
UVM	Cell metabolism gene	TIA1	PSMC6	0.850594709	1.77E-23
UVM	Cell metabolism gene	TIA1	AASS	0.851162915	1.54E-23
UVM	Cell metabolism gene	TIA1	ALG13	0.851560787	1.40E-23
UVM	Cell metabolism gene	TIA1	MTMR6	0.855116101	5.84E-24
UVM	Cell metabolism gene	TIA1	MTR	0.858642281	2.40E-24
UVM	Cell metabolism gene	TIA1	UGGT2	0.859527293	1.91E-24
UVM	Cell metabolism gene	TIA1	GXYLT1	0.862904126	7.91E-25
UVM	Cell metabolism gene	TIA1	EDEM3	0.864116891	5.73E-25
UVM	Cell metabolism gene	TIA1	ALG10B	0.86550938	3.94E-25
UVM	Cell metabolism gene	TIA1	MANEA	0.867825363	2.10E-25
UVM	Cell metabolism gene	TIA1	FBXL3	0.869610948	1.28E-25
UVM	Cell metabolism gene	TIA1	XPO1	0.896533085	2.62E-29
UVM	Cell metabolism gene	TIA1	PRKAA1	0.91134925	8.43E-32
UVM	Cell metabolism gene	TIA1	FAR1	0.927591758	4.30E-35
UVM	Cell metabolism gene	TIA1	ETNK1	0.942061639	9.50E-39
UVM	CGC	TIA1	BRCA2	0.801856656	4.01E-19
UVM	CGC	TIA1	MAP3K1	0.802946512	3.30E-19
UVM	CGC	TIA1	SMAD4	0.807393068	1.49E-19
UVM	CGC	TIA1	CASP3	0.809013091	1.10E-19
UVM	CGC	TIA1	MALT1	0.814167094	4.22E-20
UVM	CGC	TIA1	PSIP1	0.814582244	3.90E-20
UVM	CGC	TIA1	ACVR2A	0.820141314	1.33E-20
UVM	CGC	TIA1	PHF6	0.820494387	1.24E-20
UVM	CGC	TIA1	USP8	0.822240635	8.79E-21
UVM	CGC	TIA1	TRIP11	0.82511873	4.93E-21
UVM	CGC	TIA1	BCLAF1	0.826968478	3.38E-21
UVM	CGC	TIA1	TRIM33	0.82696911	3.38E-21
UVM	CGC	TIA1	CUL3	0.827180361	3.24E-21
UVM	CGC	TIA1	RGPD3	0.828337755	2.55E-21
UVM	CGC	TIA1	RAD17	0.828710257	2.36E-21
UVM	CGC	TIA1	RB1	0.831319202	1.37E-21
UVM	CGC	TIA1	ARID2	0.831736892	1.25E-21
UVM	CGC	TIA1	HOOK3	0.832003783	1.18E-21
UVM	CGC	TIA1	ITGAV	0.835946025	5.07E-22
UVM	CGC	TIA1	BMPR1A	0.836234966	4.76E-22
UVM	CGC	TIA1	AKAP9	0.838524445	2.88E-22
UVM	CGC	TIA1	MLLT10	0.841144244	1.60E-22
UVM	CGC	TIA1	RANBP2	0.842193532	1.26E-22
UVM	CGC	TIA1	ATRX	0.844445081	7.55E-23
UVM	CGC	TIA1	MDM4	0.846046375	5.21E-23
UVM	CGC	TIA1	GOPC	0.849232238	2.46E-23
UVM	CGC	TIA1	FBXW7	0.849719569	2.19E-23
UVM	CGC	TIA1	ARHGAP5	0.851071732	1.58E-23
UVM	CGC	TIA1	KRAS	0.851613679	1.38E-23
UVM	CGC	TIA1	CDC73	0.852100914	1.23E-23
UVM	CGC	TIA1	SS18L1	0.854489878	6.83E-24
UVM	CGC	TIA1	JAK2	0.856342221	4.30E-24
UVM	CGC	TIA1	DDX5	0.860442167	1.51E-24
UVM	CGC	TIA1	STAG2	0.868323822	1.83E-25
UVM	CGC	TIA1	ATM	0.872577037	5.52E-26
UVM	CGC	TIA1	KIF5B	0.873602618	4.11E-26
UVM	CGC	TIA1	ZMYM2	0.875431771	2.41E-26
UVM	CGC	TIA1	FBXO11	0.879895652	6.35E-27
UVM	CGC	TIA1	DICER1	0.885584614	1.07E-27
UVM	CGC	TIA1	BAZ1A	0.885802178	9.97E-28
UVM	CGC	TIA1	PWWP2A	0.886261856	8.60E-28
UVM	CGC	TIA1	SUZ12	0.889811247	2.68E-28
UVM	CGC	TIA1	KTN1	0.890386547	2.21E-28
UVM	CGC	TIA1	XPO1	0.896533085	2.62E-29
UVM	CGC	TIA1	TET2	0.899568296	8.70E-30
UVM	CGC	TIA1	CREB1	0.917509834	5.72E-33
UVM	CGC	TIA1	SF3B1	0.92520172	1.46E-34
UVM	CGC	TIA1	PMS1	0.933600428	1.65E-36
UVM	CGC	TIA1	ETNK1	0.942061639	9.50E-39
UVM	Epifactor	TIA1	BRCC3	0.800550336	5.04E-19
UVM	Epifactor	TIA1	BRCA2	0.801856656	4.01E-19
UVM	Epifactor	TIA1	ASF1A	0.801876104	3.99E-19
UVM	Epifactor	TIA1	ZMYND11	0.803163934	3.18E-19
UVM	Epifactor	TIA1	BRWD3	0.804543375	2.49E-19
UVM	Epifactor	TIA1	SUPT7L	0.805155018	2.23E-19
UVM	Epifactor	TIA1	ANKRD32	0.805700842	2.02E-19
UVM	Epifactor	TIA1	TAF7	0.810925163	7.75E-20
UVM	Epifactor	TIA1	SMARCA5	0.811476614	7.00E-20
UVM	Epifactor	TIA1	SETDB2	0.812491105	5.79E-20
UVM	Epifactor	TIA1	MGA	0.81306637	5.19E-20
UVM	Epifactor	TIA1	PSIP1	0.814582244	3.90E-20
UVM	Epifactor	TIA1	UCHL5	0.816689505	2.61E-20
UVM	Epifactor	TIA1	CTBP2	0.817617619	2.18E-20
UVM	Epifactor	TIA1	AEBP2	0.820535072	1.23E-20
UVM	Epifactor	TIA1	MASTL	0.823866539	6.35E-21
UVM	Epifactor	TIA1	MYSM1	0.82578173	4.31E-21
UVM	Epifactor	TIA1	CDK17	0.825913782	4.19E-21
UVM	Epifactor	TIA1	TRIM33	0.82696911	3.38E-21
UVM	Epifactor	TIA1	CUL3	0.827180361	3.24E-21
UVM	Epifactor	TIA1	BRMS1L	0.830185579	1.73E-21
UVM	Epifactor	TIA1	RB1	0.831319202	1.37E-21
UVM	Epifactor	TIA1	ARID2	0.831736892	1.25E-21
UVM	Epifactor	TIA1	MTF2	0.834043683	7.65E-22
UVM	Epifactor	TIA1	SP100	0.837562485	3.56E-22
UVM	Epifactor	TIA1	YEATS4	0.839934288	2.10E-22
UVM	Epifactor	TIA1	MLLT10	0.841144244	1.60E-22
UVM	Epifactor	TIA1	DNTTIP2	0.843142156	1.02E-22
UVM	Epifactor	TIA1	TLK1	0.843541125	9.30E-23
UVM	Epifactor	TIA1	CIR1	0.843628695	9.11E-23
UVM	Epifactor	TIA1	RLIM	0.844028848	8.31E-23
UVM	Epifactor	TIA1	ATRX	0.844445081	7.55E-23
UVM	Epifactor	TIA1	PCGF3	0.844521303	7.42E-23
UVM	Epifactor	TIA1	RMI1	0.845095557	6.50E-23
UVM	Epifactor	TIA1	CHD1	0.845459376	5.97E-23
UVM	Epifactor	TIA1	PHF20L1	0.846319357	4.89E-23
UVM	Epifactor	TIA1	NSL1	0.846564069	4.61E-23
UVM	Epifactor	TIA1	TDG	0.848056155	3.25E-23
UVM	Epifactor	TIA1	PCGF6	0.852029928	1.25E-23
UVM	Epifactor	TIA1	CDC73	0.852100914	1.23E-23
UVM	Epifactor	TIA1	HCFC2	0.854205051	7.33E-24
UVM	Epifactor	TIA1	SS18L1	0.854489878	6.83E-24
UVM	Epifactor	TIA1	JAK2	0.856342221	4.30E-24
UVM	Epifactor	TIA1	RCOR3	0.861683556	1.09E-24
UVM	Epifactor	TIA1	CUL2	0.862329913	9.20E-25
UVM	Epifactor	TIA1	UHRF2	0.866889946	2.71E-25
UVM	Epifactor	TIA1	ATM	0.872577037	5.52E-26
UVM	Epifactor	TIA1	MBTD1	0.875001774	2.74E-26
UVM	Epifactor	TIA1	ZMYM2	0.875431771	2.41E-26
UVM	Epifactor	TIA1	SMARCAD1	0.8756841	2.24E-26
UVM	Epifactor	TIA1	NIPBL	0.87588584	2.11E-26
UVM	Epifactor	TIA1	ARID4B	0.877420983	1.34E-26
UVM	Epifactor	TIA1	EID1	0.878860664	8.69E-27
UVM	Epifactor	TIA1	CUL5	0.882719019	2.65E-27
UVM	Epifactor	TIA1	PHIP	0.885618765	1.06E-27
UVM	Epifactor	TIA1	BAZ1A	0.885802178	9.97E-28
UVM	Epifactor	TIA1	SUZ12	0.889811247	2.68E-28
UVM	Epifactor	TIA1	OGT	0.891264536	1.64E-28
UVM	Epifactor	TIA1	EPC2	0.892410547	1.11E-28
UVM	Epifactor	TIA1	SMEK2	0.897011689	2.21E-29
UVM	Epifactor	TIA1	TET2	0.899568296	8.70E-30
UVM	Epifactor	TIA1	CHD9	0.903819672	1.75E-30
UVM	Epifactor	TIA1	SMEK1	0.904300656	1.45E-30
UVM	Epifactor	TIA1	HMGB1	0.905973379	7.54E-31
UVM	Epifactor	TIA1	BAZ2B	0.910239489	1.34E-31
UVM	Epifactor	TIA1	PRKAA1	0.91134925	8.43E-32
UVM	Epifactor	TIA1	JMJD1C	0.911577842	7.65E-32
UVM	Epifactor	TIA1	BRWD1	0.916486176	9.07E-33
UVM	Epifactor	TIA1	INO80D	0.917741616	5.15E-33
UVM	Epifactor	TIA1	ARID4A	0.918383078	3.84E-33
UVM	Epifactor	TIA1	USP15	0.918619962	3.44E-33
UVM	Epifactor	TIA1	SF3B1	0.92520172	1.46E-34
UVM	Epifactor	TIA1	ATAD2B	0.938576798	8.67E-38
UVM	IUPHAR	TIA1	ADAM17	0.801217185	4.48E-19
UVM	IUPHAR	TIA1	VRK2	0.801587006	4.20E-19
UVM	IUPHAR	TIA1	CYP20A1	0.802037682	3.88E-19
UVM	IUPHAR	TIA1	MAP3K1	0.802946512	3.30E-19
UVM	IUPHAR	TIA1	ZMYND11	0.803163934	3.18E-19
UVM	IUPHAR	TIA1	GLS	0.803999981	2.74E-19
UVM	IUPHAR	TIA1	BRWD3	0.804543375	2.49E-19
UVM	IUPHAR	TIA1	SLC30A7	0.805069785	2.26E-19
UVM	IUPHAR	TIA1	ABCB10	0.806623445	1.71E-19
UVM	IUPHAR	TIA1	CASP3	0.809013091	1.10E-19
UVM	IUPHAR	TIA1	NR3C1	0.80917246	1.07E-19
UVM	IUPHAR	TIA1	ABCA5	0.809806285	9.54E-20
UVM	IUPHAR	TIA1	STK38L	0.81010764	9.02E-20
UVM	IUPHAR	TIA1	SETDB2	0.812491105	5.79E-20
UVM	IUPHAR	TIA1	RPS6KC1	0.813093355	5.17E-20
UVM	IUPHAR	TIA1	MALT1	0.814167094	4.22E-20
UVM	IUPHAR	TIA1	STK17A	0.816370718	2.77E-20
UVM	IUPHAR	TIA1	PSMD14	0.816852104	2.53E-20
UVM	IUPHAR	TIA1	SMG1	0.817310082	2.31E-20
UVM	IUPHAR	TIA1	AHR	0.818209709	1.94E-20
UVM	IUPHAR	TIA1	ACVR2A	0.820141314	1.33E-20
UVM	IUPHAR	TIA1	PIKFYVE	0.82289719	7.71E-21
UVM	IUPHAR	TIA1	IFNGR1	0.82303338	7.50E-21
UVM	IUPHAR	TIA1	MASTL	0.823866539	6.35E-21
UVM	IUPHAR	TIA1	CYP2R1	0.825812061	4.28E-21
UVM	IUPHAR	TIA1	SLK	0.825865241	4.24E-21
UVM	IUPHAR	TIA1	CDK17	0.825913782	4.19E-21
UVM	IUPHAR	TIA1	TAS2R14	0.826095118	4.04E-21
UVM	IUPHAR	TIA1	TRIM33	0.82696911	3.38E-21
UVM	IUPHAR	TIA1	TRPC1	0.828069979	2.69E-21
UVM	IUPHAR	TIA1	ATP11C	0.82913453	2.16E-21
UVM	IUPHAR	TIA1	PRPF4B	0.829158474	2.15E-21
UVM	IUPHAR	TIA1	SENP7	0.831553949	1.30E-21
UVM	IUPHAR	TIA1	SENP6	0.83537248	5.74E-22
UVM	IUPHAR	TIA1	ITGAV	0.835946025	5.07E-22
UVM	IUPHAR	TIA1	BMPR1A	0.836234966	4.76E-22
UVM	IUPHAR	TIA1	PLA2G12A	0.837434593	3.66E-22
UVM	IUPHAR	TIA1	SP100	0.837562485	3.56E-22
UVM	IUPHAR	TIA1	NEK1	0.841244511	1.57E-22
UVM	IUPHAR	TIA1	RIOK3	0.842271477	1.24E-22
UVM	IUPHAR	TIA1	ABCA10	0.843367448	9.67E-23
UVM	IUPHAR	TIA1	TLK1	0.843541125	9.30E-23
UVM	IUPHAR	TIA1	CSNK1G3	0.844480598	7.49E-23
UVM	IUPHAR	TIA1	ATP6V0A2	0.844931508	6.75E-23
UVM	IUPHAR	TIA1	MARK3	0.84560158	5.78E-23
UVM	IUPHAR	TIA1	BIRC2	0.849046866	2.57E-23
UVM	IUPHAR	TIA1	BMPR2	0.849473335	2.32E-23
UVM	IUPHAR	TIA1	KRAS	0.851613679	1.38E-23
UVM	IUPHAR	TIA1	MAP3K2	0.85370655	8.29E-24
UVM	IUPHAR	TIA1	NEK7	0.85471403	6.46E-24
UVM	IUPHAR	TIA1	MAPK6	0.855554036	5.24E-24
UVM	IUPHAR	TIA1	JAK2	0.856342221	4.30E-24
UVM	IUPHAR	TIA1	MTR	0.858642281	2.40E-24
UVM	IUPHAR	TIA1	NR2C1	0.860669467	1.42E-24
UVM	IUPHAR	TIA1	IRAK4	0.860752332	1.39E-24
UVM	IUPHAR	TIA1	ATM	0.872577037	5.52E-26
UVM	IUPHAR	TIA1	NAPEPLD	0.874115254	3.54E-26
UVM	IUPHAR	TIA1	SLC4A7	0.875436999	2.41E-26
UVM	IUPHAR	TIA1	PKN2	0.877300238	1.39E-26
UVM	IUPHAR	TIA1	TBK1	0.877784074	1.20E-26
UVM	IUPHAR	TIA1	XIAP	0.878787824	8.88E-27
UVM	IUPHAR	TIA1	FBXO11	0.879895652	6.35E-27
UVM	IUPHAR	TIA1	PHIP	0.885618765	1.06E-27
UVM	IUPHAR	TIA1	BAZ1A	0.885802178	9.97E-28
UVM	IUPHAR	TIA1	TNKS2	0.887795534	5.22E-28
UVM	IUPHAR	TIA1	MAP4K3	0.889336272	3.14E-28
UVM	IUPHAR	TIA1	TRPM7	0.893455314	7.74E-29
UVM	IUPHAR	TIA1	XPO1	0.896533085	2.62E-29
UVM	IUPHAR	TIA1	CLK4	0.909899999	1.54E-31
UVM	IUPHAR	TIA1	BAZ2B	0.910239489	1.34E-31
UVM	IUPHAR	TIA1	PRKAA1	0.91134925	8.43E-32
UVM	IUPHAR	TIA1	JMJD1C	0.911577842	7.65E-32
UVM	IUPHAR	TIA1	CLK1	0.914214563	2.47E-32
UVM	IUPHAR	TIA1	BRWD1	0.916486176	9.07E-33
UVM	IUPHAR	TIA1	ATAD2B	0.938576798	8.67E-38
UVM	Kinase	TIA1	VRK2	0.801587006	4.20E-19
UVM	Kinase	TIA1	COL4A3BP	0.801990431	3.91E-19
UVM	Kinase	TIA1	MAP3K1	0.802946512	3.30E-19
UVM	Kinase	TIA1	STK38L	0.81010764	9.02E-20
UVM	Kinase	TIA1	RPS6KC1	0.813093355	5.17E-20
UVM	Kinase	TIA1	STK17A	0.816370718	2.77E-20
UVM	Kinase	TIA1	SMG1	0.817310082	2.31E-20
UVM	Kinase	TIA1	ACVR2A	0.820141314	1.33E-20
UVM	Kinase	TIA1	MASTL	0.823866539	6.35E-21
UVM	Kinase	TIA1	SLK	0.825865241	4.24E-21
UVM	Kinase	TIA1	CDK17	0.825913782	4.19E-21
UVM	Kinase	TIA1	TRIM33	0.82696911	3.38E-21
UVM	Kinase	TIA1	PRPF4B	0.829158474	2.15E-21
UVM	Kinase	TIA1	BMPR1A	0.836234966	4.76E-22
UVM	Kinase	TIA1	NEK1	0.841244511	1.57E-22
UVM	Kinase	TIA1	RIOK3	0.842271477	1.24E-22
UVM	Kinase	TIA1	TLK1	0.843541125	9.30E-23
UVM	Kinase	TIA1	CSNK1G3	0.844480598	7.49E-23
UVM	Kinase	TIA1	MARK3	0.84560158	5.78E-23
UVM	Kinase	TIA1	BMPR2	0.849473335	2.32E-23
UVM	Kinase	TIA1	MAP3K2	0.85370655	8.29E-24
UVM	Kinase	TIA1	NEK7	0.85471403	6.46E-24
UVM	Kinase	TIA1	MAPK6	0.855554036	5.24E-24
UVM	Kinase	TIA1	JAK2	0.856342221	4.30E-24
UVM	Kinase	TIA1	IRAK4	0.860752332	1.39E-24
UVM	Kinase	TIA1	PAN3	0.872025657	6.46E-26
UVM	Kinase	TIA1	ATM	0.872577037	5.52E-26
UVM	Kinase	TIA1	PKN2	0.877300238	1.39E-26
UVM	Kinase	TIA1	TBK1	0.877784074	1.20E-26
UVM	Kinase	TIA1	BAZ1A	0.885802178	9.97E-28
UVM	Kinase	TIA1	MAP4K3	0.889336272	3.14E-28
UVM	Kinase	TIA1	TRPM7	0.893455314	7.74E-29
UVM	Kinase	TIA1	CLK4	0.909899999	1.54E-31
UVM	Kinase	TIA1	PRKAA1	0.91134925	8.43E-32
UVM	Kinase	TIA1	CLK1	0.914214563	2.47E-32
UVM	TF	TIA1	ZFP14	0.800747235	4.87E-19
UVM	TF	TIA1	ZNF782	0.801846589	4.01E-19
UVM	TF	TIA1	NFAT5	0.801998315	3.91E-19
UVM	TF	TIA1	ZNF17	0.804044629	2.72E-19
UVM	TF	TIA1	ZNF320	0.804120446	2.68E-19
UVM	TF	TIA1	ZNF286A	0.804368837	2.56E-19
UVM	TF	TIA1	ZBTB11	0.805188646	2.21E-19
UVM	TF	TIA1	SMAD4	0.807393068	1.49E-19
UVM	TF	TIA1	ZNF131	0.807950088	1.34E-19
UVM	TF	TIA1	ZNF225	0.808229317	1.28E-19
UVM	TF	TIA1	ZNF791	0.808562397	1.20E-19
UVM	TF	TIA1	ZNF470	0.809009201	1.11E-19
UVM	TF	TIA1	NR3C1	0.80917246	1.07E-19
UVM	TF	TIA1	NFXL1	0.810598362	8.24E-20
UVM	TF	TIA1	RLF	0.810825387	7.90E-20
UVM	TF	TIA1	ZNF655	0.81201116	6.33E-20
UVM	TF	TIA1	ZNF101	0.812100727	6.23E-20
UVM	TF	TIA1	SETDB2	0.812491105	5.79E-20
UVM	TF	TIA1	ZNF714	0.813009281	5.25E-20
UVM	TF	TIA1	MGA	0.81306637	5.19E-20
UVM	TF	TIA1	ZNF148	0.813329475	4.94E-20
UVM	TF	TIA1	ZNF564	0.813601805	4.70E-20
UVM	TF	TIA1	ZNF253	0.814167057	4.22E-20
UVM	TF	TIA1	ZNF397	0.814698295	3.81E-20
UVM	TF	TIA1	ZNF235	0.8162297	2.85E-20
UVM	TF	TIA1	AHR	0.818209709	1.94E-20
UVM	TF	TIA1	MYBL1	0.818980661	1.67E-20
UVM	TF	TIA1	ZNF611	0.819256328	1.58E-20
UVM	TF	TIA1	ZNF558	0.820274489	1.30E-20
UVM	TF	TIA1	AEBP2	0.820535072	1.23E-20
UVM	TF	TIA1	ZNF443	0.820636328	1.21E-20
UVM	TF	TIA1	SP4	0.820653398	1.20E-20
UVM	TF	TIA1	JRKL	0.821238166	1.07E-20
UVM	TF	TIA1	ZNF200	0.821256347	1.07E-20
UVM	TF	TIA1	ZBTB6	0.821338849	1.05E-20
UVM	TF	TIA1	ZFX	0.822391177	8.53E-21
UVM	TF	TIA1	ZNF37A	0.823069096	7.45E-21
UVM	TF	TIA1	ZNF383	0.825647935	4.43E-21
UVM	TF	TIA1	MYSM1	0.82578173	4.31E-21
UVM	TF	TIA1	ZNF160	0.826205484	3.95E-21
UVM	TF	TIA1	ZNF138	0.828801021	2.32E-21
UVM	TF	TIA1	ZNF644	0.830462736	1.64E-21
UVM	TF	TIA1	ZNF107	0.831273309	1.38E-21
UVM	TF	TIA1	ARID2	0.831736892	1.25E-21
UVM	TF	TIA1	MTF2	0.834043683	7.65E-22
UVM	TF	TIA1	TOPORS	0.834071212	7.61E-22
UVM	TF	TIA1	ZNF569	0.836085858	4.92E-22
UVM	TF	TIA1	GABPA	0.836089664	4.91E-22
UVM	TF	TIA1	ZNF493	0.837070649	3.97E-22
UVM	TF	TIA1	SP100	0.837562485	3.56E-22
UVM	TF	TIA1	ZNF721	0.83805249	3.20E-22
UVM	TF	TIA1	ZNF92	0.838358862	2.99E-22
UVM	TF	TIA1	ZNF292	0.83841811	2.95E-22
UVM	TF	TIA1	ZNF440	0.839453634	2.34E-22
UVM	TF	TIA1	ZNF143	0.840014049	2.07E-22
UVM	TF	TIA1	ZNF845	0.84052682	1.84E-22
UVM	TF	TIA1	ZNF585B	0.842311518	1.23E-22
UVM	TF	TIA1	SP3	0.842773258	1.11E-22
UVM	TF	TIA1	PRDM10	0.843754709	8.85E-23
UVM	TF	TIA1	MEF2A	0.844715525	7.09E-23
UVM	TF	TIA1	BACH1	0.845035667	6.59E-23
UVM	TF	TIA1	ZNF24	0.846420961	4.77E-23
UVM	TF	TIA1	CEBPZ	0.847815062	3.44E-23
UVM	TF	TIA1	PURB	0.848079713	3.23E-23
UVM	TF	TIA1	ZNF222	0.848323588	3.05E-23
UVM	TF	TIA1	ZNF529	0.850924538	1.64E-23
UVM	TF	TIA1	ZNF326	0.851017067	1.60E-23
UVM	TF	TIA1	GPBP1	0.851856113	1.30E-23
UVM	TF	TIA1	PCGF6	0.852029928	1.25E-23
UVM	TF	TIA1	ZNF761	0.852242873	1.19E-23
UVM	TF	TIA1	ZNF14	0.853734052	8.23E-24
UVM	TF	TIA1	ZNF266	0.856214361	4.44E-24
UVM	TF	TIA1	ZNF268	0.8569858	3.66E-24
UVM	TF	TIA1	ZNF484	0.857272151	3.40E-24
UVM	TF	TIA1	ZNF430	0.857991495	2.83E-24
UVM	TF	TIA1	ZNF75D	0.858605759	2.42E-24
UVM	TF	TIA1	TMF1	0.858837141	2.28E-24
UVM	TF	TIA1	AHCTF1	0.859338997	2.01E-24
UVM	TF	TIA1	ZNF800	0.859926149	1.72E-24
UVM	TF	TIA1	NR2C1	0.860669467	1.42E-24
UVM	TF	TIA1	ZNF180	0.860687085	1.41E-24
UVM	TF	TIA1	ELF2	0.861851533	1.04E-24
UVM	TF	TIA1	ZNF28	0.862787028	8.16E-25
UVM	TF	TIA1	LIN54	0.863911385	6.05E-25
UVM	TF	TIA1	ZNF701	0.864388585	5.33E-25
UVM	TF	TIA1	ZNF141	0.864448748	5.24E-25
UVM	TF	TIA1	ZNF546	0.865133761	4.36E-25
UVM	TF	TIA1	ZNF23	0.866403349	3.09E-25
UVM	TF	TIA1	ZNF254	0.866773446	2.80E-25
UVM	TF	TIA1	ZNF624	0.866936596	2.67E-25
UVM	TF	TIA1	ZNF280D	0.867396623	2.36E-25
UVM	TF	TIA1	ZNF566	0.868505552	1.74E-25
UVM	TF	TIA1	ZNF33A	0.869853269	1.19E-25
UVM	TF	TIA1	ZBED5	0.870095497	1.11E-25
UVM	TF	TIA1	SMAD5	0.870356928	1.04E-25
UVM	TF	TIA1	ZNF606	0.870364611	1.03E-25
UVM	TF	TIA1	ZNF432	0.870845055	9.03E-26
UVM	TF	TIA1	ZBTB41	0.872069332	6.38E-26
UVM	TF	TIA1	ZNF680	0.872961049	4.94E-26
UVM	TF	TIA1	ZNF83	0.873651118	4.05E-26
UVM	TF	TIA1	THAP9	0.874202135	3.45E-26
UVM	TF	TIA1	EEA1	0.874801118	2.90E-26
UVM	TF	TIA1	ZNF302	0.875069669	2.68E-26
UVM	TF	TIA1	ZNF260	0.875160921	2.61E-26
UVM	TF	TIA1	ZMAT1	0.875783408	2.18E-26
UVM	TF	TIA1	ZNF267	0.875879383	2.12E-26
UVM	TF	TIA1	ZNF354B	0.876398993	1.81E-26
UVM	TF	TIA1	IKZF5	0.877760756	1.21E-26
UVM	TF	TIA1	ZNF780B	0.878612702	9.37E-27
UVM	TF	TIA1	ZNF234	0.879018515	8.28E-27
UVM	TF	TIA1	ZNF12	0.879593999	6.96E-27
UVM	TF	TIA1	ZNF658	0.880862697	4.72E-27
UVM	TF	TIA1	ZNF567	0.881712267	3.63E-27
UVM	TF	TIA1	ZNF140	0.88196496	3.36E-27
UVM	TF	TIA1	ZNF799	0.882543102	2.80E-27
UVM	TF	TIA1	ZNF100	0.883492956	2.08E-27
UVM	TF	TIA1	ZNF226	0.884032282	1.75E-27
UVM	TF	TIA1	ZNF674	0.884752195	1.40E-27
UVM	TF	TIA1	ZNF181	0.885523266	1.09E-27
UVM	TF	TIA1	THAP6	0.885536508	1.09E-27
UVM	TF	TIA1	ZNF480	0.885814528	9.93E-28
UVM	TF	TIA1	ZNF527	0.88657863	7.76E-28
UVM	TF	TIA1	RBAK	0.887017805	6.73E-28
UVM	TF	TIA1	ZNF449	0.887098057	6.55E-28
UVM	TF	TIA1	ZNF182	0.88939991	3.07E-28
UVM	TF	TIA1	ZNF675	0.889877257	2.62E-28
UVM	TF	TIA1	ZNF136	0.890334561	2.25E-28
UVM	TF	TIA1	ZNF10	0.890790016	1.93E-28
UVM	TF	TIA1	ZNF26	0.891680937	1.42E-28
UVM	TF	TIA1	ZNF44	0.891937234	1.30E-28
UVM	TF	TIA1	FOXN2	0.892841873	9.57E-29
UVM	TF	TIA1	THAP5	0.89370354	7.10E-29
UVM	TF	TIA1	ZNF780A	0.896662607	2.50E-29
UVM	TF	TIA1	TET2	0.899568296	8.70E-30
UVM	TF	TIA1	ZNF451	0.899593565	8.62E-30
UVM	TF	TIA1	ZNF224	0.900512905	6.13E-30
UVM	TF	TIA1	ZNF84	0.90079831	5.51E-30
UVM	TF	TIA1	ZNF510	0.908340442	2.92E-31
UVM	TF	TIA1	ZNF441	0.909482034	1.83E-31
UVM	TF	TIA1	BAZ2B	0.910239489	1.34E-31
UVM	TF	TIA1	ZNF195	0.911309734	8.57E-32
UVM	TF	TIA1	ZNF248	0.912610513	4.94E-32
UVM	TF	TIA1	ZNF700	0.914520003	2.16E-32
UVM	TF	TIA1	ZNF431	0.915724919	1.27E-32
UVM	TF	TIA1	CREB1	0.917509834	5.72E-33
UVM	TF	TIA1	ZNF43	0.919097289	2.76E-33
UVM	TF	TIA1	ZNF25	0.922311964	6.05E-34
UVM	TF	TIA1	ZBTB1	0.925611893	1.19E-34
UVM	TF	TIA1	ZNF708	0.92602366	9.63E-35
UVM	TF	TIA1	CREBZF	0.926525744	7.45E-35
UVM	TF	TIA1	DMTF1	0.935358908	5.97E-37
UVM	TF	TIA1	ZNF518A	0.948807914	8.64E-41
UVM	TSG	TIA1	TBRG1	0.800110801	5.44E-19
UVM	TSG	TIA1	BRCA2	0.801856656	4.01E-19
UVM	TSG	TIA1	ZMYND11	0.803163934	3.18E-19
UVM	TSG	TIA1	PTPN12	0.804795984	2.38E-19
UVM	TSG	TIA1	SMAD4	0.807393068	1.49E-19
UVM	TSG	TIA1	LIN9	0.809333659	1.04E-19
UVM	TSG	TIA1	EXTL2	0.813242166	5.03E-20
UVM	TSG	TIA1	AHR	0.818209709	1.94E-20
UVM	TSG	TIA1	PHF6	0.820494387	1.24E-20
UVM	TSG	TIA1	RBBP8	0.82828207	2.58E-21
UVM	TSG	TIA1	WDR11	0.830805791	1.52E-21
UVM	TSG	TIA1	RB1	0.831319202	1.37E-21
UVM	TSG	TIA1	ARID2	0.831736892	1.25E-21
UVM	TSG	TIA1	USP33	0.832327951	1.10E-21
UVM	TSG	TIA1	TOPORS	0.834071212	7.61E-22
UVM	TSG	TIA1	ITGAV	0.835946025	5.07E-22
UVM	TSG	TIA1	PDS5B	0.836000726	5.01E-22
UVM	TSG	TIA1	BMPR1A	0.836234966	4.76E-22
UVM	TSG	TIA1	SP100	0.837562485	3.56E-22
UVM	TSG	TIA1	ZNF292	0.83841811	2.95E-22
UVM	TSG	TIA1	RINT1	0.841440373	1.50E-22
UVM	TSG	TIA1	VEZT	0.842099863	1.29E-22
UVM	TSG	TIA1	NEDD4	0.844843288	6.89E-23
UVM	TSG	TIA1	CHD1	0.845459376	5.97E-23
UVM	TSG	TIA1	BMPR2	0.849473335	2.32E-23
UVM	TSG	TIA1	FBXW7	0.849719569	2.19E-23
UVM	TSG	TIA1	DCLRE1A	0.850477518	1.82E-23
UVM	TSG	TIA1	CDC73	0.852100914	1.23E-23
UVM	TSG	TIA1	INTS6	0.853507354	8.71E-24
UVM	TSG	TIA1	PPM1A	0.858681964	2.37E-24
UVM	TSG	TIA1	CUL2	0.862329913	9.20E-25
UVM	TSG	TIA1	SMCHD1	0.86305634	7.60E-25
UVM	TSG	TIA1	CCAR1	0.863635831	6.51E-25
UVM	TSG	TIA1	UHRF2	0.866889946	2.71E-25
UVM	TSG	TIA1	RB1CC1	0.868380036	1.80E-25
UVM	TSG	TIA1	FAM188A	0.869754958	1.23E-25
UVM	TSG	TIA1	ATM	0.872577037	5.52E-26
UVM	TSG	TIA1	NAPEPLD	0.874115254	3.54E-26
UVM	TSG	TIA1	TANK	0.881925832	3.40E-27
UVM	TSG	TIA1	CUL5	0.882719019	2.65E-27
UVM	TSG	TIA1	DICER1	0.885584614	1.07E-27
UVM	TSG	TIA1	KRIT1	0.887041431	6.67E-28
UVM	TSG	TIA1	SUZ12	0.889811247	2.68E-28
UVM	TSG	TIA1	APAF1	0.891465581	1.53E-28
UVM	TSG	TIA1	MLH3	0.898456523	1.31E-29
UVM	TSG	TIA1	TET2	0.899568296	8.70E-30
UVM	TSG	TIA1	PRKAA1	0.91134925	8.43E-32
UVM	TSG	TIA1	GORAB	0.934132185	1.21E-36
UVM	TSG	TIA1	DMTF1	0.935358908	5.97E-37

Top

Protein structure

Protein 3D structure
Visit iCn3D.

Top

Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KICH	TIA1	SNRPC	1.31914488567847	0.000120222568511963
KIRC	TIA1	MAPT	1.03564264895732	0.000318337905201111
HNSC	TIA1	G3BP1	1.15470167292163	0.000481783007217019
LUAD	TIA1	MAPT	1.04164019794865	0.00111597566067587
COAD	TIA1	RBM25	-3.44292945738376	0.0021815299987793
COAD	TIA1	DCP1A	1.37134624374913	0.00241076946258545
BLCA	TIA1	DCP1A	-4.97262066067438	0.0033416748046875
COAD	TIA1	HNRNPH1	-2.11871535965424	0.00513318181037904
ESCA	TIA1	RPS6KA3	1.90799647706234	0.0068359375
THCA	TIA1	RBM25	-2.68680777872162	0.010391026276801
CHOL	TIA1	MAPT	-1.22987567719576	0.02734375
LUSC	TIA1	RBM25	-2.13150027534858	0.0293070844289419
UCEC	TIA1	RPS6KA3	2.22554023919536	0.03125
LUAD	TIA1	DCP1A	-1.72675426206094	1.6717782354243e-05
LIHC	TIA1	MAPT	-4.76949427740985	1.70531249295243e-09
BRCA	TIA1	DCP1A	-1.83830661187261	1.93681541154994e-23
PRAD	TIA1	G3BP1	-4.29883961189402	2.3360983838936e-06
LUSC	TIA1	MAPT	1.30025338794925	3.95204925568617e-05
STAD	TIA1	G3BP1	-3.96377290273826	6.0301274061203e-05
COAD	TIA1	MAPT	2.31561219522476	6.03199005126954e-05
KICH	TIA1	EIF4E	1.61675210562671	6.55651092529297e-06
LUSC	TIA1	RPS6KA3	-1.92441592334707	8.91464610117726e-08
BRCA	TIA1	SNRPC	-2.40402221553371	9.39298818048331e-22

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with TIA1

FASTK, RICTOR, Rc3h1, CUL3, CUL4A, CUL5, CUL2, CUL1, COPS5, DCUN1D1, CAND1, SRSF3, WDR6, FMNL1, FN1, VCAM1, ITGA4, SOX2, BMI1, LUC7L2, MPI, PCBP1, PCBP2, PITPNB, SNRPD1, DAZAP1, DDX58, HTRA2, PIR, NTRK1, AK1, ELL2, POLK, CXXC4, NETO2, Smn1, Smek1, Cep85, ESR1, DPPA4, BCOR, NANOG, POU5F1, G3BP1, ESR2, PHB, UBQLN2, MAPT, ANXA7, ITFG1, EWSR1, ARIH2, HCVgp1, TRIM25, HSCB, EIF4ENIF1, FUBP3, RAVER1, SMN1, TDRD3, USP11, DDX20, GORASP2, RBM20, RC3H2, TOP3B, TXNL1, UPF1, GEMIN4, R3HDM1, ALG13, KCTD12, KIAA0753, KIDINS220, OTUD4, RBM33, C2orf44, MKI67, BCAR1, WBP4, EGFR, LGALS9,

Top

Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
TIA1	chr2	70439855	TG	T	Deletion	Uncertain_significance	Welander_distal_myopathy	SO:0001589\|frameshift_variant,SO:0001619\|non-coding_transcript_variant	SO:0001589\|frameshift_variant,SO:0001619\|non-coding_transcript_variant
TIA1	chr2	70439862	C	T	single_nucleotide_variant	Pathogenic	Welander_distal_myopathy\|not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TIA1	chr2	70439866	C	A	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
TIA1	chr2	70439871	C	T	single_nucleotide_variant	Pathogenic	Amyotrophic_lateral_sclerosis_26_with_or_without_frontotemporal_dementia	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TIA1	chr2	70439890	C	T	single_nucleotide_variant	Benign	Welander_distal_myopathy	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
TIA1	chr2	70439894	T	C	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TIA1	chr2	70439895	T	C	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TIA1	chr2	70439904	T	C	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TIA1	chr2	70439911	A	G	single_nucleotide_variant	Benign	Welander_distal_myopathy	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
TIA1	chr2	70439916	G	A	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001587\|nonsense,SO:0001619\|non-coding_transcript_variant	SO:0001587\|nonsense,SO:0001619\|non-coding_transcript_variant
TIA1	chr2	70439926	C	T	single_nucleotide_variant	Benign	Welander_distal_myopathy\|not_specified	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
TIA1	chr2	70439927	G	A	single_nucleotide_variant	Uncertain_significance	AMYOTROPHIC_LATERAL_SCLEROSIS_26_WITH_FRONTOTEMPORAL_DEMENTIA\|Welander_distal_myopathy	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TIA1	chr2	70439930	T	G	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TIA1	chr2	70439934	C	T	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TIA1	chr2	70439942	T	C	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Welander_distal_myopathy\|not_specified\|not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TIA1	chr2	70441331	T	TA	Duplication	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70441361	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70441483	A	G	single_nucleotide_variant	Likely_benign	Welander_distal_myopathy	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
TIA1	chr2	70441509	C	T	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy\|not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TIA1	chr2	70441523	G	A	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TIA1	chr2	70441537	A	G	single_nucleotide_variant	Benign	Welander_distal_myopathy	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
TIA1	chr2	70441544	G	C	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TIA1	chr2	70441562	T	C	single_nucleotide_variant	Benign/Likely_benign	Welander_distal_myopathy\|not_specified\|not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TIA1	chr2	70441564	T	C	single_nucleotide_variant	Likely_benign	Welander_distal_myopathy	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
TIA1	chr2	70441568	G	C	single_nucleotide_variant	Benign	Welander_distal_myopathy	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TIA1	chr2	70441591	C	T	single_nucleotide_variant	Benign	Welander_distal_myopathy	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
TIA1	chr2	70441597	A	G	single_nucleotide_variant	Likely_benign	Welander_distal_myopathy\|not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
TIA1	chr2	70441602	G	A	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TIA1	chr2	70441627	C	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001574\|splice_acceptor_variant,SO:0001627\|intron_variant	SO:0001574\|splice_acceptor_variant,SO:0001627\|intron_variant
TIA1	chr2	70441775	A	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70441778	A	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70441783	A	AC	Insertion	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70441783	A	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70442511	C	T	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TIA1	chr2	70442522	A	G	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TIA1	chr2	70442545	A	G	single_nucleotide_variant	Likely_benign	Welander_distal_myopathy	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
TIA1	chr2	70442586	C	T	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TIA1	chr2	70442616	G	T	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TIA1	chr2	70442621	T	A	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TIA1	chr2	70442722	ACAGTTTG	A	Deletion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70442792	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70443165	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70443330	C	T	single_nucleotide_variant	Likely_benign	Welander_distal_myopathy	SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant
TIA1	chr2	70443341	G	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TIA1	chr2	70443366	A	G	single_nucleotide_variant	Likely_benign	Welander_distal_myopathy	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
TIA1	chr2	70443413	G	T	single_nucleotide_variant	Likely_benign	Welander_distal_myopathy	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TIA1	chr2	70443415	A	G	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TIA1	chr2	70443421	T	A	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TIA1	chr2	70443433	C	CA	Duplication	Likely_benign	Welander_distal_myopathy	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70443518	C	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70443528	TC	T	Deletion	Likely_benign	Welander_distal_myopathy	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70443600	A	C	single_nucleotide_variant	Likely_benign	Welander_distal_myopathy	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
TIA1	chr2	70443618	C	G	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TIA1	chr2	70443636	T	G	single_nucleotide_variant	Likely_benign	Welander_distal_myopathy	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70444039	C	A	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TIA1	chr2	70444040	G	A	single_nucleotide_variant	Likely_benign	Welander_distal_myopathy	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
TIA1	chr2	70444061	G	A	single_nucleotide_variant	Likely_benign	Welander_distal_myopathy	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
TIA1	chr2	70444097	A	G	single_nucleotide_variant	Likely_benign	Welander_distal_myopathy	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
TIA1	chr2	70444121	A	G	single_nucleotide_variant	Likely_benign	Welander_distal_myopathy	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
TIA1	chr2	70444129	G	A	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70444134	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70444436	G	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70451402	G	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70451604	GA	G	Deletion	Benign	not_provided	SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant
TIA1	chr2	70451676	C	A	single_nucleotide_variant	Likely_benign	Welander_distal_myopathy\|not_provided	SO:0001583\|missense_variant,SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant
TIA1	chr2	70451728	T	C	single_nucleotide_variant	Likely_benign	Welander_distal_myopathy	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001624\|3_prime_UTR_variant
TIA1	chr2	70451738	A	G	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
TIA1	chr2	70451784	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70454794	G	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70454857	T	C	single_nucleotide_variant	Likely_benign	Welander_distal_myopathy	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70454864	T	C	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70454867	G	A	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant,SO:0001624\|3_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant,SO:0001624\|3_prime_UTR_variant
TIA1	chr2	70454885	G	A	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant,SO:0001624\|3_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant,SO:0001624\|3_prime_UTR_variant
TIA1	chr2	70454937	C	T	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant
TIA1	chr2	70454944	A	G	single_nucleotide_variant	Likely_benign	Welander_distal_myopathy	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant
TIA1	chr2	70454954	T	A	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
TIA1	chr2	70455204	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70455907	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70456218	T	A	single_nucleotide_variant	Likely_benign	Welander_distal_myopathy	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
TIA1	chr2	70456338	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70456389	T	C	single_nucleotide_variant	Likely_benign	Welander_distal_myopathy	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70456390	A	ACTT	Duplication	Uncertain_significance	Welander_distal_myopathy	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70456390	A	C	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70456436	A	G	single_nucleotide_variant	Likely_benign	Welander_distal_myopathy	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant
TIA1	chr2	70456443	T	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
TIA1	chr2	70456452	TA	T	Deletion	Benign	Welander_distal_myopathy\|not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70456453	A	T	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70456586	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70457609	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70457628	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70457740	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70457784	C	CA	Duplication	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70457784	C	CAA	Duplication	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70457784	CA	C	Deletion	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70457901	T	A	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
TIA1	chr2	70457903	C	T	single_nucleotide_variant	Likely_benign	Welander_distal_myopathy	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant
TIA1	chr2	70457905	G	T	single_nucleotide_variant	Likely_benign	Welander_distal_myopathy	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant
TIA1	chr2	70457923	A	G	single_nucleotide_variant	Likely_benign	Welander_distal_myopathy	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant
TIA1	chr2	70457943	T	C	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
TIA1	chr2	70457956	C	T	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
TIA1	chr2	70457967	T	C	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
TIA1	chr2	70458267	T	TA	Duplication	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70463168	T	TA	Duplication	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70463236	C	A	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
TIA1	chr2	70463241	T	C	single_nucleotide_variant	Benign	Welander_distal_myopathy	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
TIA1	chr2	70463259	T	C	single_nucleotide_variant	Benign	Welander_distal_myopathy\|not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
TIA1	chr2	70463264	G	C	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
TIA1	chr2	70463286	T	C	single_nucleotide_variant	Likely_benign	Welander_distal_myopathy	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
TIA1	chr2	70463292	A	G	single_nucleotide_variant	Likely_benign	Welander_distal_myopathy	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
TIA1	chr2	70463301	G	A	single_nucleotide_variant	Likely_benign	Welander_distal_myopathy	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
TIA1	chr2	70463304	G	A	single_nucleotide_variant	Benign	Welander_distal_myopathy\|not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
TIA1	chr2	70463313	A	T	single_nucleotide_variant	Uncertain_significance	Welander_distal_myopathy	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70463334	C	CT	Duplication	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TIA1	chr2	70475562	T	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
TIA1	chr2	70475565	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
TIA1	chr2	70475699	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
TIA1	chr2	70475827	T	G	single_nucleotide_variant	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
TIA1	chr2	70475933	T	G	single_nucleotide_variant	Benign	not_provided

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
TIA1	CESC	chr2	70454866	70454866	C	T	Splice_Site		5
TIA1	UCS	chr2	70441492	70441492	C	A	Missense_Mutation	p.Q341H	3
TIA1	ESCA	chr2	70442603	70442603	G	A	Missense_Mutation	p.A263V	3
TIA1	BRCA	chr2	70454946	70454946	G	A	Missense_Mutation	p.H107Y	3
TIA1	BRCA	chr2	70475537	70475538	AG	-	Frame_Shift_Del	p.L9fs	3
TIA1	LGG	chr2	70454956	70454956	T	G	Splice_Site		2
TIA1	UCEC	chr2	70439877	70439877	G	C	Missense_Mutation	p.R379G	2
TIA1	STAD	chr2	70454867	70454867	G	A	Missense_Mutation	p.S133L	2
TIA1	UCEC	chr2	70444097	70444097	A	T	Silent	p.G168	2
TIA1	CESC	chr2	70454926	70454926	G	T	Silent		2
TIA1	STAD	chr2	70441551	70441551	A	G	Missense_Mutation	p.Y322H	2
TIA1	UCEC	chr2	70456215	70456215	C	T	Missense_Mutation	p.V96I	2
TIA1	STAD	chr2	70441502	70441502	G	A	Missense_Mutation	p.A338V	2
TIA1	UCEC	chr2	70463223	70463223	T	G	Missense_Mutation	p.K37N	2
TIA1	UCEC	chr2	70463300	70463300	C	T	Missense_Mutation	p.G12S	2
TIA1	THYM	chr2	70442556	70442556	C	A	Missense_Mutation	p.V279L	2
TIA1	LUAD	chr2	70451749	70451749	C	A	Silent	p.V137V	2
TIA1	SKCM	chr2	70441545	70441545	G	A	Missense_Mutation	p.P324S	2
TIA1	BRCA	chr2	70439953	70439953	C	G	Missense_Mutation	p.W353C	2
TIA1	SARC	chr2	70441617	70441617	T	-	Frame_Shift_Del	p.I300fs	2
TIA1	BRCA	chr2	70442526	70442526	C	G	Missense_Mutation	p.D289H	2
TIA1	ESCA	chr2	70442603	70442603	G	A	Missense_Mutation		2
TIA1	SKCM	chr2	70457969	70457969	G	A	Silent	p.P47P	2
TIA1	MESO	chr2	70457911	70457911	T	G	Missense_Mutation	p.N67H	1
TIA1	HNSC	chr2	70444000	70444000	C	G	Missense_Mutation		1
TIA1	SKCM	chr2	70451754	70451754	G	A	Nonsense_Mutation	p.R136*	1
TIA1	LIHC	chr2	70441567	70441567	T	C	Silent	p.A316A	1
TIA1	PRAD	chr2	70439876	70439876	C	T	Missense_Mutation	p.R379Q	1
TIA1	HNSC	chr2	70443968	70443968	G	A	Silent		1
TIA1	SKCM	chr2	70443564	70443564	G	T	Nonsense_Mutation	p.Y217*	1
TIA1	ACC	chr2	70443366	70443366	A	G	Silent	p.F246F	1
TIA1	LIHC	chr2	70451743	70451743	T	-	Frame_Shift_Del	p.K139fs	1
TIA1	CESC	chr2	70454926	70454926	G	T	Nonsense_Mutation	p.S153*	1
TIA1	PRAD	chr2	70463280	70463280	C	T	Silent	p.V18V	1
TIA1	HNSC	chr2	70451687	70451687	C	T	Splice_Site	p.W158_splice	1
TIA1	SKCM	chr2	70456423	70456423	G	A	Missense_Mutation	p.P84S	1
TIA1	BLCA	chr2	70463264	70463264	G	T	Missense_Mutation		1
TIA1	LUAD	chr2	70457967	70457967	T	C	Missense_Mutation	p.Y48C	1
TIA1	COAD	chr2	70439942	70439942	T	C	Missense_Mutation	p.N346S	1
TIA1	SARC	chr2	70441617	70441617	T	-	Frame_Shift_Del		1
TIA1	HNSC	chr2	70443968	70443968	G	A	Silent	p.Y211Y	1
TIA1	SKCM	chr2	70454947	70454947	G	A	Silent	p.F106F	1
TIA1	STAD	chr2	70454891	70454891	G	A	Missense_Mutation	p.A125V	1
TIA1	BLCA	chr2	70475553	70475553	C	T	Missense_Mutation		1
TIA1	LUAD	chr2	70441501	70441501	T	A	Silent	p.A338A	1
TIA1	COAD	chr2	70443374	70443374	G	A	Nonsense_Mutation	p.R233X	1
TIA1	SARC	chr2	70457982	70457982	G	T	Missense_Mutation		1
TIA1	HNSC	chr2	70444000	70444000	C	G	Missense_Mutation	p.E201Q	1
TIA1	SKCM	chr2	70454867	70454867	G	A	Splice_Site	p.S133_splice	1
TIA1	THCA	chr2	70444040	70444040	G	T	Silent		1
TIA1	BLCA	chr2	70475553	70475553	C	T	Missense_Mutation	p.E4K	1
TIA1	LUAD	chr2	70454899	70454899	T	A	Silent	p.I122I	1
TIA1	UCS	chr2	70441492	70441492	C	A	Missense_Mutation		1
TIA1	COAD	chr2	70456453	70456455	AAA	-	Splice_Site	.	1
TIA1	SARC	chr2	70443577	70443577	T	A	Missense_Mutation		1
TIA1	HNSC	chr2	70475554	70475554	G	A	Silent	p.D3D	1
TIA1	SKCM	chr2	70444040	70444040	G	A	Silent	p.P187P	1
TIA1	BLCA	chr2	70463276	70463276	C	T	Missense_Mutation	p.E20K	1
TIA1	SARC	chr2	70463261	70463261	G	T	Missense_Mutation		1
TIA1	KICH	chr2	70463215	70463215	A	G	Missense_Mutation		1
TIA1	UCEC	chr2	70444097	70444097	A	T	Silent	p.G168G	1
TIA1	LUSC	chr2	70441526	70441526	G	A	Missense_Mutation	p.P330L	1
TIA1	ESCA	chr2	70443921	70443921	T	C	RNA	NULL	1
TIA1	KIRC	chr2	70441538	70441538	C	G	Missense_Mutation	p.G326A	1
TIA1	SKCM	chr2	70451695	70451696	-	A	Frame_Shift_Ins	p.*155fs	1
TIA1	UCEC	chr2	70463241	70463241	T	C	Silent	p.G31G	1
TIA1	LUSC	chr2	70443373	70443373	C	T	Missense_Mutation	p.R244Q	1
TIA1	SARC	chr2	70443577	70443577	T	A	Missense_Mutation	p.N213I	1
TIA1	KIRC	chr2	70456452	70456452	T	A	Splice_Site	.	1
TIA1	STAD	chr2	70454866	70454866	C	T	Splice_Site	.	1
TIA1	UCEC	chr2	70442597	70442597	G	A	Missense_Mutation	p.A265V	1
TIA1	LUSC	chr2	70456422	70456422	G	C	Missense_Mutation	p.P84R	1
TIA1	GBM	chr2	70457951	70457951	A	-	Frame_Shift_Del	p.F53fs	1
TIA1	KIRC	chr2	70475612	70475612	C	T	Translation_Start_Site		1
TIA1	STAD	chr2	70456453	70456454	AA	-	Splice_Site	.	1
TIA1	UCEC	chr2	70444017	70444019	CAC	-	Splice_Site	p.S195_splice	1
TIA1	LUSC	chr2	70457920	70457920	C	G	Missense_Mutation	p.A64P	1
TIA1	GBM	chr2	70443394	70443394	A	C	Missense_Mutation		1
TIA1	SKCM	chr2	70441545	70441545	G	A	Missense_Mutation	p.P313S	1

Copy number variation (CNV) of TIA1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across TIA1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
100607	UCS	TCGA-N8-A4PP-01A	GPR35	chr2	241546029	-	TIA1	chr2	70444126	-
100607	OV	TCGA-61-1917	HNRNPR	chr1	23664246	-	TIA1	chr2	70444126	-
100607	ESCA	TCGA-L5-A43C	LSM12	chr17	42141168	-	TIA1	chr2	70444126	-
100607	N/A	DN917109	LUC7L	chr16	250876	-	TIA1	chr2	70437715	+
100607	OV	TCGA-20-1684	MAP4K5	chr14	50906730	-	TIA1	chr2	70443631	-
100607	ESCA	TCGA-L7-A6VZ	RPS27A	chr2	55461340	+	TIA1	chr2	70444126	-
90824	PRAD	TCGA-KK-A7AP	TIA1	chr2	70463210	-	ACTR2	chr2	65478160	+
90824	PRAD	TCGA-KK-A7AP-01A	TIA1	chr2	70463211	-	ACTR2	chr2	65478161	+
90824	LUAD	TCGA-64-1676-01A	TIA1	chr2	70475537	-	BCL11A	chr2	60695968	-
90824	LUAD	TCGA-64-1676-01A	TIA1	chr2	70475537	-	BCL11A	chr2	60743653	-
90824	LGG	TCGA-HT-7676	TIA1	chr2	70456190	-	C6orf48	chr6	31805012	+
90824	LUSC	TCGA-94-8491-01A	TIA1	chr2	70475537	-	FAM136A	chr2	70528112	-
90824	N/A	T06637	TIA1	chr2	70444115	+	HSPA13	chr21	15746130	+
92247	LGG	TCGA-QH-A6XC-01A	TIA1	chr2	70475537	-	MRPL33	chr2	28002300	+
90824	BLCA	TCGA-GU-A767-01A	TIA1	chr2	70475537	-	OSTC	chr4	109576720	+
90824	ESCA	TCGA-L5-A8NE-01A	TIA1	chr2	70443340	-	SNRPG	chr2	70508816	-
90824	BRCA	TCGA-AR-A256	TIA1	chr2	70475536	-	TGFA	chr2	70692865	-
90824	BRCA	TCGA-AR-A256	TIA1	chr2	70475536	-	TGFA	chr2	70692868	-
90824	BRCA	TCGA-AR-A256-01A	TIA1	chr2	70475537	-	TGFA	chr2	70692865	-
90824	BRCA	TCGA-AR-A256-01A	TIA1	chr2	70475537	-	TGFA	chr2	70692868	-
100607	N/A	DL057496	TIA1	chr2	70437611	-	TIA1	chr2	70437588	+
98380	N/A	BE172300	TIA1	chr2	70458852	-	ZFYVE26	chr14	68228868	-
100607	N/A	BM148702	TPTE2P1	chr13	25536074	+	TIA1	chr2	70437988	+
100607	N/A	BM145777	TPTE2P6	chr13	25161274	-	TIA1	chr2	70437988	+
100607	Non-Cancer	91N	TRNAU1AP	chr1	28887244	+	TIA1	chr2	70441626	-
100607	KIRC	TCGA-CZ-4860-01A	ZC3H8	chr2	112991697	-	TIA1	chr2	70444126	-

Top

Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

Top

Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	TIA1	0.000784153702643851	0.022
HNSC	TIA1	0.00398562759286185	0.11
PCPG	TIA1	0.0126034531419111	0.33
COAD	TIA1	0.0176192180565669	0.44
SARC	TIA1	0.021714982526284	0.52
GBM	TIA1	0.0261977869684422	0.6
THCA	TIA1	0.0463760142555901	1

Top

Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	TIA1	0.000365481960328509	0.012
STAD	TIA1	0.0426023350761196	1
THCA	TIA1	0.000936864522659231	0.028
BRCA	TIA1	1.44185789060546e-06	4.8e-05
CESC	TIA1	0.0127228144276144	0.36
BLCA	TIA1	0.0194064260063478	0.52
THYM	TIA1	0.00275530413798138	0.08
SARC	TIA1	0.000458704614090173	0.014
HNSC	TIA1	0.0236220350771991	0.61

Top

Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0221054	Welander Distal Myopathy	3	GENOMICS_ENGLAND;ORPHANET;UNIPROT
C2931290	Welander distal myopathy, Swedish type	3	CTD_human;ORPHANET