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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: TUFM (NCBI Gene ID:7284)

Gene Summary

Gene Summary

Gene Information	Gene Name: TUFM
	Gene ID: 7284
	Gene Symbol	TUFM
	Gene ID	7284
	Gene Name	Tu translation elongation factor, mitochondrial
	Synonyms	COXPD4\|EF-TuMT\|EFTU\|P43
	Cytomap	16p11.2
	Type of Gene	protein-coding
	Description	elongation factor Tu, mitochondrialEF-Tuepididymis secretory sperm binding protein
	Modification date	20200313
	UniProtAcc	P49411

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0032543	Mitochondrial translation
GO:0008135	Translation factor activity, RNA binding
GO:0006414	Translational elongation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TUFM	GO:0006414	translational elongation	9332382

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
TUFM	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'TUFM[title] AND translation [title] AND human.'

Gene	Title	PMID
TUFM	Autophagy-competent mitochondrial translation elongation factor TUFM inhibits caspase-8-mediated apoptosis	34511600

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000313511	28855550	28855655	In-frame
ENST00000313511	28856634	28856801	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000313511	28855550	28855655	2088	957	1061	452	272	307

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P49411	272	307	44	452	Chain	ID=PRO_0000007462;Note=Elongation factor Tu%2C mitochondrial
P49411	272	307	278	278	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
P49411	272	307	286	286	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q8BFR5

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
PRAD	TUFM	-1.2256313171173	0.0103593733400852
STAD	TUFM	-1.51047864320184	0.0216239951550961
CHOL	TUFM	-1.80802756669144	0.02734375
LUSC	TUFM	-1.71731823082899	1.01729583501094e-06
BRCA	TUFM	-1.46208284468293	3.49579812063892e-10
LUAD	TUFM	-2.06131065114905	7.73559543739736e-08
KICH	TUFM	1.55570480198217	8.80360603332519e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
PRAD	TUFM	-0.102869148	0.012235878
COAD	TUFM	-0.025931686	0.037057846
TGCT	TUFM	0.087822314	0.039533778

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with TUFM (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	TUFM	GPX4	0.809187057	1.73E-11
CHOL	Cell metabolism gene	TUFM	POLD2	0.816089429	8.45E-12
DLBC	Cell metabolism gene	TUFM	ADSL	0.803441709	6.30E-12
DLBC	Cell metabolism gene	TUFM	SNRPD3	0.805171045	5.24E-12
DLBC	Cell metabolism gene	TUFM	NME2	0.81343071	2.13E-12
DLBC	Cell metabolism gene	TUFM	TOMM22	0.824454917	5.95E-13
DLBC	TF	TUFM	NME2	0.81343071	2.13E-12
LAML	Cell metabolism gene	TUFM	TIMM50	0.802371657	3.54E-40
LAML	Cell metabolism gene	TUFM	ECHS1	0.802946257	2.83E-40
LAML	Cell metabolism gene	TUFM	APRT	0.811411569	9.80E-42
LAML	TSG	TUFM	GADD45GIP1	0.80091847	6.19E-40
PRAD	Cell metabolism gene	TUFM	TIMM13	0.806098167	5.89E-127
PRAD	Epifactor	TUFM	RUVBL2	0.803252697	2.08E-125
THCA	Cell metabolism gene	TUFM	ALDOA	0.811326953	5.26E-135
THYM	Cell metabolism gene	TUFM	POLE4	0.800383743	1.95E-28
THYM	Cell metabolism gene	TUFM	PHKG2	0.803190786	9.12E-29
THYM	Cell metabolism gene	TUFM	LSM4	0.806084738	4.11E-29
THYM	Cell metabolism gene	TUFM	IDH3B	0.809092763	1.77E-29
THYM	Cell metabolism gene	TUFM	HSD17B10	0.81115802	9.86E-30
THYM	Cell metabolism gene	TUFM	PMM2	0.81147347	9.01E-30
THYM	Cell metabolism gene	TUFM	PSMB7	0.81309433	5.65E-30
THYM	Cell metabolism gene	TUFM	PSMA7	0.813628636	4.84E-30
THYM	Cell metabolism gene	TUFM	TOMM5	0.813782031	4.63E-30
THYM	Cell metabolism gene	TUFM	PTGES2	0.814058379	4.27E-30
THYM	Cell metabolism gene	TUFM	APRT	0.81527837	2.99E-30
THYM	Cell metabolism gene	TUFM	POLR2I	0.816574189	2.04E-30
THYM	Cell metabolism gene	TUFM	PSMC4	0.821045659	5.36E-31
THYM	Cell metabolism gene	TUFM	PSMC5	0.821195035	5.12E-31
THYM	Cell metabolism gene	TUFM	PSMC3	0.821386455	4.83E-31
THYM	Cell metabolism gene	TUFM	TIMM10	0.822322103	3.63E-31
THYM	Cell metabolism gene	TUFM	SNRPD2	0.823231306	2.75E-31
THYM	Cell metabolism gene	TUFM	TBCB	0.823266868	2.72E-31
THYM	Cell metabolism gene	TUFM	POLD2	0.825374914	1.41E-31
THYM	Cell metabolism gene	TUFM	POLR3K	0.825955306	1.18E-31
THYM	Cell metabolism gene	TUFM	TOMM22	0.826061169	1.14E-31
THYM	Cell metabolism gene	TUFM	PGP	0.826920354	8.72E-32
THYM	Cell metabolism gene	TUFM	ACOT8	0.827352724	7.60E-32
THYM	Cell metabolism gene	TUFM	SNRPE	0.829265867	4.14E-32
THYM	Cell metabolism gene	TUFM	WBSCR22	0.832540221	1.44E-32
THYM	Cell metabolism gene	TUFM	GRPEL1	0.832715584	1.36E-32
THYM	Cell metabolism gene	TUFM	TIMM17B	0.833999492	8.90E-33
THYM	Cell metabolism gene	TUFM	FDPS	0.834758148	6.92E-33
THYM	Cell metabolism gene	TUFM	POLR2H	0.83572532	5.02E-33
THYM	Cell metabolism gene	TUFM	TIMM8B	0.835876766	4.77E-33
THYM	Cell metabolism gene	TUFM	EXOSC5	0.837374677	2.89E-33
THYM	Cell metabolism gene	TUFM	ATIC	0.839931921	1.21E-33
THYM	Cell metabolism gene	TUFM	TIMM13	0.840202109	1.10E-33
THYM	Cell metabolism gene	TUFM	GEMIN6	0.841912368	6.09E-34
THYM	Cell metabolism gene	TUFM	PSMB3	0.842069276	5.77E-34
THYM	Cell metabolism gene	TUFM	EBP	0.842364268	5.20E-34
THYM	Cell metabolism gene	TUFM	CCT7	0.842445552	5.06E-34
THYM	Cell metabolism gene	TUFM	CCT3	0.842813525	4.45E-34
THYM	Cell metabolism gene	TUFM	DTYMK	0.844277985	2.66E-34
THYM	Cell metabolism gene	TUFM	ITPA	0.844917752	2.12E-34
THYM	Cell metabolism gene	TUFM	TIMM50	0.84615602	1.36E-34
THYM	Cell metabolism gene	TUFM	SRM	0.848342712	6.17E-35
THYM	Cell metabolism gene	TUFM	NME2	0.84840072	6.04E-35
THYM	Cell metabolism gene	TUFM	PSMB4	0.850997619	2.32E-35
THYM	Cell metabolism gene	TUFM	TSTA3	0.857636215	1.86E-36
THYM	Cell metabolism gene	TUFM	NOP56	0.862654732	2.52E-37
THYM	Cell metabolism gene	TUFM	NANS	0.867159517	3.92E-38
THYM	Cell metabolism gene	TUFM	PYCRL	0.870393279	9.87E-39
THYM	Cell metabolism gene	TUFM	TOMM40	0.875337575	1.11E-39
THYM	Cell metabolism gene	TUFM	MTX1	0.875855591	8.82E-40
THYM	Cell metabolism gene	TUFM	NME1	0.877097204	5.01E-40
THYM	Cell metabolism gene	TUFM	DOHH	0.878435211	2.71E-40
THYM	Cell metabolism gene	TUFM	TPI1	0.878992297	2.09E-40
THYM	Cell metabolism gene	TUFM	HMOX2	0.882654228	3.71E-41
THYM	Cell metabolism gene	TUFM	PSMD4	0.885276605	1.04E-41
THYM	Cell metabolism gene	TUFM	GEMIN7	0.887638908	3.19E-42
THYM	Cell metabolism gene	TUFM	ATP5G1	0.888330816	2.25E-42
THYM	Cell metabolism gene	TUFM	PMPCA	0.890202044	8.65E-43
THYM	Cell metabolism gene	TUFM	HMBS	0.890995189	5.74E-43
THYM	Cell metabolism gene	TUFM	EXOSC4	0.903886981	4.47E-46
THYM	Cell metabolism gene	TUFM	CYC1	0.906273783	1.06E-46
THYM	CGC	TUFM	PRCC	0.803391043	8.63E-29
THYM	CGC	TUFM	CDK4	0.807405888	2.85E-29
THYM	CGC	TUFM	COX6C	0.814659081	3.59E-30
THYM	CGC	TUFM	ATIC	0.839931921	1.21E-33
THYM	CGC	TUFM	SDHAF2	0.857982611	1.62E-36
THYM	Epifactor	TUFM	PPP4C	0.80549049	4.85E-29
THYM	Epifactor	TUFM	RUVBL2	0.807773774	2.57E-29
THYM	Epifactor	TUFM	PRPF31	0.809269697	1.69E-29
THYM	Epifactor	TUFM	PPM1G	0.810169608	1.31E-29
THYM	Epifactor	TUFM	NAP1L4	0.811936862	7.89E-30
THYM	Epifactor	TUFM	SIRT6	0.812415474	6.87E-30
THYM	Epifactor	TUFM	VPS72	0.81346866	5.07E-30
THYM	Epifactor	TUFM	BRMS1	0.832707272	1.36E-32
THYM	Epifactor	TUFM	CDK5	0.835364992	5.66E-33
THYM	Epifactor	TUFM	EXOSC5	0.837374677	2.89E-33
THYM	Epifactor	TUFM	PRMT1	0.840649948	9.44E-34
THYM	Epifactor	TUFM	RRP8	0.851019816	2.30E-35
THYM	Epifactor	TUFM	EXOSC4	0.903886981	4.47E-46
THYM	IUPHAR	TUFM	PHKG2	0.803190786	9.12E-29
THYM	IUPHAR	TUFM	MPDU1	0.80398305	7.34E-29
THYM	IUPHAR	TUFM	ATP6V0B	0.804361293	6.62E-29
THYM	IUPHAR	TUFM	CDK4	0.807405888	2.85E-29
THYM	IUPHAR	TUFM	FKBP1A	0.809351066	1.65E-29
THYM	IUPHAR	TUFM	SIRT6	0.812415474	6.87E-30
THYM	IUPHAR	TUFM	PTGES2	0.814058379	4.27E-30
THYM	IUPHAR	TUFM	USP5	0.81456992	3.68E-30
THYM	IUPHAR	TUFM	ECE2	0.82400898	2.16E-31
THYM	IUPHAR	TUFM	FDPS	0.834758148	6.92E-33
THYM	IUPHAR	TUFM	CDK5	0.835364992	5.66E-33
THYM	IUPHAR	TUFM	PRMT1	0.840649948	9.44E-34
THYM	IUPHAR	TUFM	HMOX2	0.882654228	3.71E-41
THYM	Kinase	TUFM	PHKG2	0.803190786	9.12E-29
THYM	Kinase	TUFM	CDK4	0.807405888	2.85E-29
THYM	Kinase	TUFM	ADCK4	0.817654165	1.48E-30
THYM	Kinase	TUFM	CDK5	0.835364992	5.66E-33
THYM	TF	TUFM	ZNF511	0.801208704	1.56E-28
THYM	TF	TUFM	ZNF787	0.812451813	6.80E-30
THYM	TF	TUFM	USF1	0.814068494	4.26E-30
THYM	TF	TUFM	ZNF668	0.818711103	1.08E-30
THYM	TF	TUFM	ZNF688	0.84565072	1.63E-34
THYM	TF	TUFM	ZNF581	0.848245467	6.39E-35
THYM	TF	TUFM	NME2	0.84840072	6.04E-35
THYM	TSG	TUFM	GADD45GIP1	0.802240307	1.18E-28
THYM	TSG	TUFM	RTN4IP1	0.804488109	6.39E-29
THYM	TSG	TUFM	PINX1	0.806096397	4.10E-29
THYM	TSG	TUFM	SIRT6	0.812415474	6.87E-30
THYM	TSG	TUFM	PHB	0.817109842	1.74E-30
THYM	TSG	TUFM	ZNF668	0.818711103	1.08E-30
THYM	TSG	TUFM	TSSC4	0.82461625	1.79E-31
THYM	TSG	TUFM	BRMS1	0.832707272	1.36E-32
THYM	TSG	TUFM	NME1	0.877097204	5.01E-40
THYM	TSG	TUFM	STUB1	0.894278561	1.01E-43
UCEC	Epifactor	TUFM	PPP4C	0.819258132	5.95E-50
UCS	Cell metabolism gene	TUFM	POLE4	0.800383743	1.95E-28
UCS	Cell metabolism gene	TUFM	PHKG2	0.803190786	9.12E-29
UCS	Cell metabolism gene	TUFM	LSM4	0.806084738	4.11E-29
UCS	Cell metabolism gene	TUFM	IDH3B	0.809092763	1.77E-29
UCS	Cell metabolism gene	TUFM	HSD17B10	0.81115802	9.86E-30
UCS	Cell metabolism gene	TUFM	PMM2	0.81147347	9.01E-30
UCS	Cell metabolism gene	TUFM	PSMB7	0.81309433	5.65E-30
UCS	Cell metabolism gene	TUFM	PSMA7	0.813628636	4.84E-30
UCS	Cell metabolism gene	TUFM	TOMM5	0.813782031	4.63E-30
UCS	Cell metabolism gene	TUFM	PTGES2	0.814058379	4.27E-30
UCS	Cell metabolism gene	TUFM	APRT	0.81527837	2.99E-30
UCS	Cell metabolism gene	TUFM	POLR2I	0.816574189	2.04E-30
UCS	Cell metabolism gene	TUFM	PSMC4	0.821045659	5.36E-31
UCS	Cell metabolism gene	TUFM	PSMC5	0.821195035	5.12E-31
UCS	Cell metabolism gene	TUFM	PSMC3	0.821386455	4.83E-31
UCS	Cell metabolism gene	TUFM	TIMM10	0.822322103	3.63E-31
UCS	Cell metabolism gene	TUFM	SNRPD2	0.823231306	2.75E-31
UCS	Cell metabolism gene	TUFM	TBCB	0.823266868	2.72E-31
UCS	Cell metabolism gene	TUFM	POLD2	0.825374914	1.41E-31
UCS	Cell metabolism gene	TUFM	POLR3K	0.825955306	1.18E-31
UCS	Cell metabolism gene	TUFM	TOMM22	0.826061169	1.14E-31
UCS	Cell metabolism gene	TUFM	PGP	0.826920354	8.72E-32
UCS	Cell metabolism gene	TUFM	ACOT8	0.827352724	7.60E-32
UCS	Cell metabolism gene	TUFM	SNRPE	0.829265867	4.14E-32
UCS	Cell metabolism gene	TUFM	WBSCR22	0.832540221	1.44E-32
UCS	Cell metabolism gene	TUFM	GRPEL1	0.832715584	1.36E-32
UCS	Cell metabolism gene	TUFM	TIMM17B	0.833999492	8.90E-33
UCS	Cell metabolism gene	TUFM	FDPS	0.834758148	6.92E-33
UCS	Cell metabolism gene	TUFM	POLR2H	0.83572532	5.02E-33
UCS	Cell metabolism gene	TUFM	TIMM8B	0.835876766	4.77E-33
UCS	Cell metabolism gene	TUFM	EXOSC5	0.837374677	2.89E-33
UCS	Cell metabolism gene	TUFM	ATIC	0.839931921	1.21E-33
UCS	Cell metabolism gene	TUFM	TIMM13	0.840202109	1.10E-33
UCS	Cell metabolism gene	TUFM	GEMIN6	0.841912368	6.09E-34
UCS	Cell metabolism gene	TUFM	PSMB3	0.842069276	5.77E-34
UCS	Cell metabolism gene	TUFM	EBP	0.842364268	5.20E-34
UCS	Cell metabolism gene	TUFM	CCT7	0.842445552	5.06E-34
UCS	Cell metabolism gene	TUFM	CCT3	0.842813525	4.45E-34
UCS	Cell metabolism gene	TUFM	DTYMK	0.844277985	2.66E-34
UCS	Cell metabolism gene	TUFM	ITPA	0.844917752	2.12E-34
UCS	Cell metabolism gene	TUFM	TIMM50	0.84615602	1.36E-34
UCS	Cell metabolism gene	TUFM	SRM	0.848342712	6.17E-35
UCS	Cell metabolism gene	TUFM	NME2	0.84840072	6.04E-35
UCS	Cell metabolism gene	TUFM	PSMB4	0.850997619	2.32E-35
UCS	Cell metabolism gene	TUFM	TSTA3	0.857636215	1.86E-36
UCS	Cell metabolism gene	TUFM	NOP56	0.862654732	2.52E-37
UCS	Cell metabolism gene	TUFM	NANS	0.867159517	3.92E-38
UCS	Cell metabolism gene	TUFM	PYCRL	0.870393279	9.87E-39
UCS	Cell metabolism gene	TUFM	TOMM40	0.875337575	1.11E-39
UCS	Cell metabolism gene	TUFM	MTX1	0.875855591	8.82E-40
UCS	Cell metabolism gene	TUFM	NME1	0.877097204	5.01E-40
UCS	Cell metabolism gene	TUFM	DOHH	0.878435211	2.71E-40
UCS	Cell metabolism gene	TUFM	TPI1	0.878992297	2.09E-40
UCS	Cell metabolism gene	TUFM	HMOX2	0.882654228	3.71E-41
UCS	Cell metabolism gene	TUFM	PSMD4	0.885276605	1.04E-41
UCS	Cell metabolism gene	TUFM	GEMIN7	0.887638908	3.19E-42
UCS	Cell metabolism gene	TUFM	ATP5G1	0.888330816	2.25E-42
UCS	Cell metabolism gene	TUFM	PMPCA	0.890202044	8.65E-43
UCS	Cell metabolism gene	TUFM	HMBS	0.890995189	5.74E-43
UCS	Cell metabolism gene	TUFM	EXOSC4	0.903886981	4.47E-46
UCS	Cell metabolism gene	TUFM	CYC1	0.906273783	1.06E-46
UCS	CGC	TUFM	PRCC	0.803391043	8.63E-29
UCS	CGC	TUFM	CDK4	0.807405888	2.85E-29
UCS	CGC	TUFM	COX6C	0.814659081	3.59E-30
UCS	CGC	TUFM	ATIC	0.839931921	1.21E-33
UCS	CGC	TUFM	SDHAF2	0.857982611	1.62E-36
UCS	Epifactor	TUFM	PPP4C	0.80549049	4.85E-29
UCS	Epifactor	TUFM	RUVBL2	0.807773774	2.57E-29
UCS	Epifactor	TUFM	PRPF31	0.809269697	1.69E-29
UCS	Epifactor	TUFM	PPM1G	0.810169608	1.31E-29
UCS	Epifactor	TUFM	NAP1L4	0.811936862	7.89E-30
UCS	Epifactor	TUFM	SIRT6	0.812415474	6.87E-30
UCS	Epifactor	TUFM	VPS72	0.81346866	5.07E-30
UCS	Epifactor	TUFM	BRMS1	0.832707272	1.36E-32
UCS	Epifactor	TUFM	CDK5	0.835364992	5.66E-33
UCS	Epifactor	TUFM	EXOSC5	0.837374677	2.89E-33
UCS	Epifactor	TUFM	PRMT1	0.840649948	9.44E-34
UCS	Epifactor	TUFM	RRP8	0.851019816	2.30E-35
UCS	Epifactor	TUFM	EXOSC4	0.903886981	4.47E-46
UCS	IUPHAR	TUFM	PHKG2	0.803190786	9.12E-29
UCS	IUPHAR	TUFM	MPDU1	0.80398305	7.34E-29
UCS	IUPHAR	TUFM	ATP6V0B	0.804361293	6.62E-29
UCS	IUPHAR	TUFM	CDK4	0.807405888	2.85E-29
UCS	IUPHAR	TUFM	FKBP1A	0.809351066	1.65E-29
UCS	IUPHAR	TUFM	SIRT6	0.812415474	6.87E-30
UCS	IUPHAR	TUFM	PTGES2	0.814058379	4.27E-30
UCS	IUPHAR	TUFM	USP5	0.81456992	3.68E-30
UCS	IUPHAR	TUFM	ECE2	0.82400898	2.16E-31
UCS	IUPHAR	TUFM	FDPS	0.834758148	6.92E-33
UCS	IUPHAR	TUFM	CDK5	0.835364992	5.66E-33
UCS	IUPHAR	TUFM	PRMT1	0.840649948	9.44E-34
UCS	IUPHAR	TUFM	HMOX2	0.882654228	3.71E-41
UCS	Kinase	TUFM	PHKG2	0.803190786	9.12E-29
UCS	Kinase	TUFM	CDK4	0.807405888	2.85E-29
UCS	Kinase	TUFM	ADCK4	0.817654165	1.48E-30
UCS	Kinase	TUFM	CDK5	0.835364992	5.66E-33
UCS	TF	TUFM	ZNF511	0.801208704	1.56E-28
UCS	TF	TUFM	ZNF787	0.812451813	6.80E-30
UCS	TF	TUFM	USF1	0.814068494	4.26E-30
UCS	TF	TUFM	ZNF668	0.818711103	1.08E-30
UCS	TF	TUFM	ZNF688	0.84565072	1.63E-34
UCS	TF	TUFM	ZNF581	0.848245467	6.39E-35
UCS	TF	TUFM	NME2	0.84840072	6.04E-35
UCS	TSG	TUFM	GADD45GIP1	0.802240307	1.18E-28
UCS	TSG	TUFM	RTN4IP1	0.804488109	6.39E-29
UCS	TSG	TUFM	PINX1	0.806096397	4.10E-29
UCS	TSG	TUFM	SIRT6	0.812415474	6.87E-30
UCS	TSG	TUFM	PHB	0.817109842	1.74E-30
UCS	TSG	TUFM	ZNF668	0.818711103	1.08E-30
UCS	TSG	TUFM	TSSC4	0.82461625	1.79E-31
UCS	TSG	TUFM	BRMS1	0.832707272	1.36E-32
UCS	TSG	TUFM	NME1	0.877097204	5.01E-40
UCS	TSG	TUFM	STUB1	0.894278561	1.01E-43
UVM	Cell metabolism gene	TUFM	POLR2E	0.802972252	3.29E-19
UVM	Cell metabolism gene	TUFM	POLD2	0.803461102	3.01E-19
UVM	Cell metabolism gene	TUFM	AAAS	0.808711026	1.17E-19
UVM	Cell metabolism gene	TUFM	PGLS	0.824254643	5.87E-21
UVM	Cell metabolism gene	TUFM	TIMM13	0.842627467	1.15E-22
UVM	Epifactor	TUFM	RUVBL2	0.823350391	7.04E-21

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KICH	TUFM	MRPS5	1.25108287838437	0.000249803066253662
COAD	TUFM	RPS3	1.48730375143014	0.000411599874496461
KICH	TUFM	TSFM	1.15779807454151	0.00129634141921997
KIRP	TUFM	GFM1	-3.60557651795202	0.00154796987771988
LIHC	TUFM	MRPS7	1.27029395477208	0.00182077236082954
STAD	TUFM	MRPS16	-1.64208084987431	0.00239070039242506
KICH	TUFM	GFM1	1.05246565332639	0.00378090143203735
CHOL	TUFM	MRPL2	-1.49926301466752	0.00390625
KIRP	TUFM	ATG5	1.1864249167445	0.00471024587750435
HNSC	TUFM	MRPS16	-2.01564621821803	0.00518989327406416
STAD	TUFM	NLRX1	-1.81592860972512	0.00779616041108966
ESCA	TUFM	MRPS5	-2.15440118747854	0.0185546875
HNSC	TUFM	RPS3	-4.73505819095135	0.0273726439852453
BLCA	TUFM	MRPL2	-3.29210657477178	0.0445594787597656
LUAD	TUFM	MRPL2	-1.26727646741024	1.07341296213058e-06
LUSC	TUFM	TSFM	-3.83005339359833	1.4433166414012e-09
LUAD	TUFM	MRPS5	-2.20881945885927	1.77904381378076e-06
BRCA	TUFM	TSFM	-2.93602416019673	2.90907687062967e-14
LUSC	TUFM	MRPS5	-7.65956389962319	4.27210217182982e-06
LUAD	TUFM	GFM1	-2.84901818322678	4.2869535120076e-07
THCA	TUFM	NLRX1	1.45552016138751	5.28599587070605e-07
KIRC	TUFM	RPL11	-5.47536848868151	6.13619476098216e-10
BRCA	TUFM	GFM1	1.76831243345242	7.05963288731276e-10
THCA	TUFM	ATG5	-1.2377895092677	7.21410444734473e-06
LUSC	TUFM	MRPL2	-2.66710222706783	7.24218086307245e-08
KIRC	TUFM	RPS3	-1.29560847926387	9.05905681935088e-10
LUAD	TUFM	TSFM	-4.00047669194892	9.20176185683847e-09
BRCA	TUFM	MRPS7	-2.12787460270434	9.33194208595055e-10

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with TUFM

SGK1, BANF1, tat, UBC, PPP2R2B, ICT1, AGO4, HDAC5, NOP56, SIRT7, CUL3, CUL4B, CUL5, CUL2, CDK2, COPS5, GRK5, RPL17, RPL23, RPL11, RPL8, RPS11, RPS15A, RPS2, RPS23, RPL7, RPL6, RPL9, RPL23A, RPL19, RPS24, RPL14, RPL12, RPL15, RPS6, RPL32, RPL37A, RPS16, RPS8, RPL3, RPS13, RPL31, RPS3, RPS20, RPS26, RPS5, MRPS7, MRPL17, MRPL11, NACA2, MRPL14, MRPS14, MRPL22, MRPL4, MRPL24, MRPS5, MRPL23, PPT2, PRKCDBP, MRPS10, HSP90AA1, MRPL2, PHB2, SFXN3, SARS2, MRPL1, IARS2, NENF, SNCG, ENG, AK2, PC, SMURF1, FMNL1, FN1, VCAM1, C1QBP, UBL4A, ZSWIM7, PAN2, CD81, NPM1, ADRB2, EXOSC6, FBXO6, PARK2, DCPS, GAPDH, IPO9, NAE1, PAFAH1B2, PPP1R2, PPP5C, PROSC, TUBB6, ASL, CAMK1D, CAPN2, CLU, GTF3C4, HEXB, HK1, NSFL1C, PDIA4, PLAA, TUBB2A, UBXN1, XPO1, ASB10, ASB12, ASB14, ASB17, SPRTN, HUWE1, FUS, ARL6IP1, CMTM5, FUNDC1, FAM9B, CUL7, OBSL1, CCDC8, SUZ12, RNF2, BMI1, TSSK1B, RPS6KB2, CHMP7, DDOST, HIP1R, ARF1, CANX, CLTC, GFM1, HNRNPL, LMAN1, MRPL18, MRPL3, POLR3A, PTBP1, RAB5B, RPN1, SEPHS1, SLC25A3, UQCRC2, WDR12, NTRK1, PTEN, Ckap5, SKI, CRY2, MCM2, ERBB3, ESRRB, U2AF2, COA3, NFATC1, NFATC2, ATOH1, AIFM1, BECN1, ZNF746, EGFR, ZMYM6, GFM2, MTIF2, MCCC1, GAB1, PTPRK, DEFA5, DKKL1, PUS1, ST8SIA4, MUC20, CYLD, G3BP1, TES, ZNF598, PHF19, EGLN3, ARMC8, DDX39B, PPEF1, PPP2R2C, TGFB1, BMPR1A, COPE, GSK3A, HSPA8, PCBP1, PPP6C, HIF1A, AAR2, EFTUD2, RPTOR, TNIP2, RNF4, TNF, RIOK1, MEPCE, RNF123, SNAI1, AGR2, RECQL4, REST, MYC, TUBA1A, METTL3, METTL14, WTAP, KIAA1429, AMBRA1, ATG16L1, PHB, FAF1, RBX1, SSBP1, ARMC12, TMEM41B, NR2C2, UBQLN2, PPARG, MTDH, CTCF, PRDM16, MECOM, LRRC59, RCN2, SLC25A24, POR, AGPS, APOE, ATP5B, NNT, HMOX2, ASPH, NDUFS3, NDUFS1, NDUFA8, NDUFS7, P4HA1, BCKDHA, CORO1C, EMC2, CYC1, APP, NDUFS8, LACTB, VCP, EEF2, NDUFV1, NDUFB10, IRF2, BCL2L14, NT5C3A, TNFRSF10A, ARAF, BIRC3, LMBR1L, BRD7, Hsp22, TRIM28, RHBDD2, SYP, ZDHHC15, MTIF3, HMBOX1, TNFRSF10D, DGAT2L6, USP5, PLEKHA4, PINK1, YAP1, TFCP2, FANCD2, HCVgp1, LINC01554, PCAT1, TRIM6, ZC3H18, MTA2, SH3GL3, SHOC2, TNK2, VAV1, NME1-NME2, VASH1, B3GNT7, CCNL2, MYO5C, RABL2B, SMARCA1, DUSP3, SMC1A, TAF7L, ZC2HC1B, KDELC2, PRX, REV1, GPR111, SNIP1, ANKRD55, nsp6, ORF8, ESR1, NEK4, LRRC31, CIT, ANLN, AURKB, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, BRD9, MTG2, AARS2, ABCB7, ACAD9, ACAT1, ACOT1, ACOT2, AFG3L2, AK4, ALAS1, ALDH2, ALDH4A1, ANGEL2, ATAD3A, ATAD3B, ATP5D, ATPIF1, ATP5J2-PTCD1, ATP5F1, ATP5H, ATP5J, ATP5O, ATPAF1, BCS1L, C17orf80, C7orf55-LUC7L2, CARS2, CLPP, CLPX, COX4I1, COX5A, CRYZ, CS, DAP3, DBT, DHX30, DLAT, DLST, DPCD, EARS2, ECHS1, ECI2, ECSIT, ELAC2, ERAL1, ETFA, ETFB, FASTKD2, FASTKD5, FECH, FLAD1, GADD45GIP1, GARS, GATB, GATC, GLS, GLUD1, GRPEL1, GRSF1, GTPBP10, GTPBP3, GTPBP6, GUF1, HADH, HADHA, HARS2, HINT2, HNRNPAB, HNRNPDL, HNRNPR, HNRNPUL1, HSD17B10, HSDL2, HSP90B1, HSPE1, IBA57, LARS2, LETM1, LRPPRC, LYRM4, MDH2, METTL15, MGME1, MMAB, RNMTL1, MRPL10, MRPL12, MRPL13, MRPL15, MRPL16, MRPL19, MRPL20, MRPL21, MRPL27, MRPL28, MRPL30, MRPL37, MRPL38, MRPL39, MRPL40, MRPL41, MRPL42, MRPL43, MRPL44, MRPL45, MRPL46, MRPL47, MRPL48, MRPL49, MRPL50, MRPL51, MRPL52, MRPL53, MRPL9, MRPS11, MRPS16, MRPS17, MRPS18A, MRPS18B, MRPS18C, MRPS2, MRPS22, MRPS23, MRPS24, MRPS25, MRPS26, MRPS27, MRPS28, MRPS30, MRPS31, MRPS33, MRPS34, MRPS35, MRPS36, MRPS6, MRPS9, MTERF3, MTHFD2, NARS2, NDUFA12, NDUFA2, NDUFA5, NDUFA6, NDUFA7, NDUFA9, NDUFAF1, NDUFAF2, NDUFAF3, NDUFAF4, NDUFS2, NDUFS4, NDUFS6, NDUFV2, NDUFV3, NFS1, NIPSNAP1, NME4, NT5DC2, NUDT19, OGDH, PAM16, PDE12, PDHA1, PDHB, PDHX, PDK3, PDPR, PMPCA, PNPLA8, PNPT1, POLDIP2, POLG, POLRMT, PPA2, PPIF, PRDX3, PREPL, PTCD3, PYCR2, QRSL1, RARS2, RBMX, SDHB, SHMT2, SLC30A9, SLIRP, STOML2, SUCLA2, SUPV3L1, SYNCRIP, TACO1, TARS2, THEM4, THNSL1, TIMM44, TIMMDC1, TRMT10C, TRMT5, TRMT61B, TSFM, C10orf2, UQCC1, VARS2, VWA8, ZC3H4, INS, NDN, BRD4, CIC, Apc2, RBM39, FBP1, LGALS9, WDR76, EIF3H, UCHL1, KDF1, OGT, BAG5, SPOP, UFL1, DDRGK1, RHBDD1, TRIM37, ATG7, FZR1, WDR5, PAGE4, BGLT3, BAGE2, RAB33A, IL12RB1, KLK5, TMEM25, DTX3, BTF3, EP300, FBXW7, NLRX1, TMPRSS2, TOP3B, CTSL, CLEC4D, nsp4, ORF10, ORF6, ORF7b, S, FGD5, CCNF, CNR2, PLK1, NR3C1, ZEB1, PIGR,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
TUFM	chr16	28853735	T	A	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
TUFM	chr16	28853779	C	G	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
TUFM	chr16	28853851	C	T	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
TUFM	chr16	28853863	A	G	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
TUFM	chr16	28853898	C	T	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
TUFM	chr16	28853926	A	C	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
TUFM	chr16	28853947	C	T	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
TUFM	chr16	28853996	A	C	single_nucleotide_variant	Benign	Combined_oxidative_phosphorylation_deficiency_4\|not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
TUFM	chr16	28854026	G	A	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
TUFM	chr16	28854067	C	T	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
TUFM	chr16	28854147	C	G	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
TUFM	chr16	28854186	T	C	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
TUFM	chr16	28854236	A	C	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
TUFM	chr16	28854259	C	T	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
TUFM	chr16	28854272	G	A	single_nucleotide_variant	Benign	Combined_oxidative_phosphorylation_deficiency_4\|not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
TUFM	chr16	28854300	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TUFM	chr16	28854316	T	C	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TUFM	chr16	28854356	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TUFM	chr16	28854372	T	C	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Combined_oxidative_phosphorylation_deficiency_4\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TUFM	chr16	28854393	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TUFM	chr16	28854422	C	T	single_nucleotide_variant	Likely_benign	not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TUFM	chr16	28854449	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TUFM	chr16	28854455	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TUFM	chr16	28854468	T	C	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TUFM	chr16	28854472	A	G	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Combined_oxidative_phosphorylation_deficiency\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TUFM	chr16	28854479	G	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TUFM	chr16	28854495	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TUFM	chr16	28854769	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TUFM	chr16	28855131	C	T	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Combined_oxidative_phosphorylation_deficiency_4\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TUFM	chr16	28855262	A	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant	SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant
TUFM	chr16	28855329	C	T	single_nucleotide_variant	Pathogenic	Combined_oxidative_phosphorylation_deficiency_4	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TUFM	chr16	28855349	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TUFM	chr16	28855356	C	G	single_nucleotide_variant	Likely_pathogenic	Combined_oxidative_phosphorylation_deficiency_4	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TUFM	chr16	28855370	G	A	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TUFM	chr16	28855382	G	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TUFM	chr16	28855429	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TUFM	chr16	28855431	G	T	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TUFM	chr16	28855497	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TUFM	chr16	28855522	G	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TUFM	chr16	28855535	G	A	single_nucleotide_variant	Benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TUFM	chr16	28855543	T	C	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Combined_oxidative_phosphorylation_deficiency_4\|not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TUFM	chr16	28855564	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
TUFM	chr16	28855579	A	G	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
TUFM	chr16	28855600	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
TUFM	chr16	28855622	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
TUFM	chr16	28855648	G	C	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TUFM	chr16	28855653	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TUFM	chr16	28855721	G	C	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TUFM	chr16	28855724	C	G	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TUFM	chr16	28855727	A	G	single_nucleotide_variant	Benign	Combined_oxidative_phosphorylation_deficiency_4\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TUFM	chr16	28855747	G	A	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TUFM	chr16	28855757	G	A	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TUFM	chr16	28855797	C	T	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Combined_oxidative_phosphorylation_deficiency_4\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TUFM	chr16	28855798	G	A	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Combined_oxidative_phosphorylation_deficiency_4\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TUFM	chr16	28855904	C	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TUFM	chr16	28856010	C	T	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TUFM	chr16	28856011	G	A	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Combined_oxidative_phosphorylation_deficiency_4\|not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TUFM	chr16	28856013	G	A	single_nucleotide_variant	Benign/Likely_benign	Combined_oxidative_phosphorylation_deficiency_4\|not_specified\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TUFM	chr16	28856081	C	T	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TUFM	chr16	28856084	T	G	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TUFM	chr16	28856105	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TUFM	chr16	28856108	C	G	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TUFM	chr16	28856122	A	G	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TUFM	chr16	28856135	G	A	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4	SO:0001587\|nonsense	SO:0001587\|nonsense
TUFM	chr16	28856141	C	T	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TUFM	chr16	28856145	A	G	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Combined_oxidative_phosphorylation_deficiency_4\|not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TUFM	chr16	28856191	T	A	single_nucleotide_variant	Benign/Likely_benign	Combined_oxidative_phosphorylation_deficiency_4\|not_specified\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TUFM	chr16	28856196	G	C	single_nucleotide_variant	Likely_benign	Combined_oxidative_phosphorylation_deficiency_4\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TUFM	chr16	28856240	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TUFM	chr16	28856257	C	T	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Combined_oxidative_phosphorylation_deficiency_4\|not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TUFM	chr16	28856258	C	G	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TUFM	chr16	28856321	T	C	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TUFM	chr16	28856351	A	T	single_nucleotide_variant	Pathogenic	Combined_oxidative_phosphorylation_deficiency_4	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TUFM	chr16	28856364	C	T	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TUFM	chr16	28856382	G	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TUFM	chr16	28856729	C	G	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TUFM	chr16	28856814	A	C	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TUFM	chr16	28856819	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TUFM	chr16	28857282	G	A	single_nucleotide_variant	Benign	Combined_oxidative_phosphorylation_deficiency_4\|not_specified\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TUFM	chr16	28857314	G	C	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TUFM	chr16	28857317	CG	C	Deletion	Pathogenic	Combined_oxidative_phosphorylation_deficiency_4	SO:0001587\|nonsense	SO:0001587\|nonsense
TUFM	chr16	28857363	C	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TUFM	chr16	28857380	G	C	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TUFM	chr16	28857399	C	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TUFM	chr16	28857408	G	A	single_nucleotide_variant	Benign/Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TUFM	chr16	28857438	C	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TUFM	chr16	28857556	G	C	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TUFM	chr16	28857571	G	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TUFM	chr16	28857579	C	A	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TUFM	chr16	28857585	G	A	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Combined_oxidative_phosphorylation_deficiency_4\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TUFM	chr16	28857590	T	C	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant
TUFM	chr16	28857601	C	T	single_nucleotide_variant	Likely_benign	not_specified	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
TUFM	chr16	28857612	G	T	single_nucleotide_variant	Likely_benign	not_specified	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
TUFM	chr16	28857624	G	A	single_nucleotide_variant	Benign	not_specified	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
TUFM	chr16	28857627	G	A	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
TUFM	chr16	28857634	C	A	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
TUFM	chr16	28857638	CAGA	C	Microsatellite	Conflicting_interpretations_of_pathogenicity	Combined_oxidative_phosphorylation_deficiency\|not_provided	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
TUFM	chr16	28857645	A	G	single_nucleotide_variant	Benign	Combined_oxidative_phosphorylation_deficiency_4\|not_provided	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
TUFM	chr16	28857651	G	A	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_4	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
TUFM	chr16	28857671	C	G	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency
TUFM	chr16	28857718	C	G	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency
TUFM	chr16	28857722	C	T	single_nucleotide_variant	Benign/Likely_benign	Combined_oxidative_phosphorylation_deficiency\|not_provided

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
TUFM	BRCA	chr16	28855746	28855746	C	T	Missense_Mutation	p.V271I	5
TUFM	THYM	chr16	28854394	28854394	G	A	Missense_Mutation	p.R424C	4
TUFM	BRCA	chr16	28854300	28854300	C	T	Missense_Mutation	p.G455D	4
TUFM	UCEC	chr16	28854319	28854319	C	T	Missense_Mutation	p.E449K	3
TUFM	UCS	chr16	28855116	28855116	G	T	Missense_Mutation	p.P379T	3
TUFM	BRCA	chr16	28855150	28855150	A	C	Silent	p.G367	3
TUFM	HNSC	chr16	28856350	28856350	G	A	Silent	p.L147L	3
TUFM	LUAD	chr16	28856776	28856776	C	T	Silent	p.K91K	2
TUFM	ESCA	chr16	28857357	28857357	G	A	Silent	p.L41L	2
TUFM	LUAD	chr16	28856763	28856763	C	T	Missense_Mutation	p.E96K	2
TUFM	SKCM	chr16	28857367	28857367	G	A	Missense_Mutation	p.A38V	2
TUFM	KIRC	chr16	28857318	28857318	G	A	Silent	p.Y54Y	2
TUFM	LUAD	chr16	28856035	28856035	G	A	Missense_Mutation	p.A223V	2
TUFM	UCEC	chr16	28855752	28855752	A	G	Missense_Mutation	p.Y269H	2
TUFM	LUAD	chr16	28855408	28855408	G	A	Missense_Mutation	p.H313Y	2
TUFM	STAD	chr16	28856763	28856763	C	T	Missense_Mutation		2
TUFM	UCEC	chr16	28856095	28856095	C	A	Missense_Mutation	p.R203L	2
TUFM	SKCM	chr16	28857331	28857331	G	A	Missense_Mutation	p.A50V	2
TUFM	BLCA	chr16	28857543	28857543	G	A	Silent	p.F16F	2
TUFM	STAD	chr16	28856666	28856666	G	A	Missense_Mutation		2
TUFM	UCEC	chr16	28856681	28856681	C	T	Missense_Mutation	p.R123H	2
TUFM	SKCM	chr16	28855302	28855302	G	A	Missense_Mutation	p.S348F	2
TUFM	BLCA	chr16	28855344	28855344	C	T	Missense_Mutation	p.R334Q	2
TUFM	STAD	chr16	28856666	28856666	G	A	Missense_Mutation	p.T128I	2
TUFM	STAD	chr16	28856346	28856346	C	T	Missense_Mutation	p.G149S	2
TUFM	SKCM	chr16	28855798	28855798	G	A	Silent	p.P253P	2
TUFM	STAD	chr16	28855126	28855126	G	A	Silent	p.S375S	2
TUFM	ESCA	chr16	28855330	28855330	G	-	Frame_Shift_Del	p.R339fs	2
TUFM	STAD	chr16	28855345	28855345	G	A	Missense_Mutation	p.R334W	2
TUFM	LIHC	chr16	28856298	28856298	G	-	Frame_Shift_Del	p.R165fs	2
TUFM	SKCM	chr16	28855799	28855799	G	A	Missense_Mutation	p.P253L	2
TUFM	CESC	chr16	28854451	28854451	C	T	Missense_Mutation		2
TUFM	ESCA	chr16	28857357	28857357	G	A	Silent		2
TUFM	CESC	chr16	28856133	28856133	C	C	Missense_Mutation		1
TUFM	SKCM	chr16	28856102	28856102	C	T	Missense_Mutation	p.E201K	1
TUFM	SKCM	chr16	28854470	28854470	C	T	Splice_Site	.	1
TUFM	BLCA	chr16	28855344	28855344	C	T	Missense_Mutation		1
TUFM	HNSC	chr16	28855381	28855381	C	T	Missense_Mutation	p.G322R	1
TUFM	COAD	chr16	28855325	28855325	G	A	Silent	p.G340G	1
TUFM	SKCM	chr16	28855778	28855778	G	A	Missense_Mutation	p.P260L	1
TUFM	ESCA	chr16	28854356	28854356	G	A	Silent	p.T436T	1
TUFM	BLCA	chr16	28856664	28856664	C	G	Missense_Mutation		1
TUFM	COAD	chr16	28855374	28855374	T	C	Missense_Mutation	p.N324S	1
TUFM	SKCM	chr16	28854312	28854314	TTC	-	In_Frame_Del	p.KN450del	1
TUFM	ESCA	chr16	28855330	28855330	G	C	Missense_Mutation	p.R339G	1
TUFM	SKCM	chr16	28855288	28855288	G	A	Nonsense_Mutation	p.Q353X	1
TUFM	BLCA	chr16	28855329	28855329	C	T	Missense_Mutation	p.R339Q	1
TUFM	LGG	chr16	28855624	28855624	C	T	Silent	p.E283E	1
TUFM	COAD	chr16	28855623	28855623	G	A	Missense_Mutation	p.R284C	1
TUFM	GBM	chr16	28855057	28855057	C	A	Missense_Mutation		1
TUFM	LGG	chr16	28855565	28855565	C	T	Missense_Mutation	p.R303H	1
TUFM	COAD	chr16	28855652	28855652	C	T	Missense_Mutation	p.R274H	1
TUFM	LUAD	chr16	28857418	28857418	G	T	Missense_Mutation	p.A21D	1
TUFM	HNSC	chr16	28856350	28856350	G	A	Silent		1
TUFM	LGG	chr16	28855565	28855565	C	T	Missense_Mutation		1
TUFM	COAD	chr16	28856796	28856796	C	T	Missense_Mutation	p.A85T	1
TUFM	LUAD	chr16	28855558	28855559	CA	-	Frame_Shift_Del	p.V306fs	1
TUFM	UCS	chr16	28855116	28855116	G	T	Missense_Mutation		1
TUFM	HNSC	chr16	28855381	28855381	C	T	Missense_Mutation		1
TUFM	SKCM	chr16	28855288	28855288	G	A	Nonsense_Mutation	p.Q353*	1
TUFM	BLCA	chr16	28856664	28856664	C	G	Missense_Mutation	p.D129H	1
TUFM	LIHC	chr16	28856082	28856082	G	T	Silent		1
TUFM	DLBC	chr16	28854369	28854369	C	T	Missense_Mutation	p.R432Q	1
TUFM	LUSC	chr16	28855622	28855622	C	G	Missense_Mutation	p.R284P	1
TUFM	HNSC	chr16	28856724	28856724	T	C	Missense_Mutation		1
TUFM	SKCM	chr16	28855357	28855357	G	A	Nonsense_Mutation	p.R330*	1
TUFM	LIHC	chr16	28856082	28856082	G	T	Silent	p.T207T	1
TUFM	OV	chr16	28763585	28763585	T	G	Missense_Mutation		1
TUFM	HNSC	chr16	28854443	28854443	C	T	Silent		1
TUFM	LIHC	chr16	28857319	28857319	T	A	Missense_Mutation	p.Y54F	1
TUFM	SKCM	chr16	28854470	28854470	C	T	Splice_Site		1
TUFM	ESCA	chr16	28857357	28857357	G	A	Silent	p.L41	1
TUFM	PRAD	chr16	28854382	28854382	G	A	Nonsense_Mutation	p.R428*	1
TUFM	SKCM	chr16	28856098	28856098	A	G	Missense_Mutation	p.I202T	1
TUFM	STAD	chr16	28855078	28855078	C	A	Silent	p.R391R	1
TUFM	ESCA	chr16	28855330	28855330	G	-	Frame_Shift_Del		1
TUFM	BLCA	chr16	28857282	28857282	G	C	Missense_Mutation		1
TUFM	HNSC	chr16	28854443	28854443	C	T	Silent	p.L407L	1
TUFM	LIHC	chr16	28854401	28854401	T	-	Frame_Shift_Del	p.K421fs	1
TUFM	SKCM	chr16	28856096	28856096	G	A	Missense_Mutation	p.R203W	1
TUFM	THYM	chr16	28855272	28855272	T	C	Missense_Mutation	p.Q358R	1
TUFM	SKCM	chr16	28855357	28855357	G	A	Nonsense_Mutation	p.R330X	1
TUFM	BLCA	chr16	28855329	28855329	C	T	Missense_Mutation		1
TUFM	HNSC	chr16	28856724	28856724	T	C	Missense_Mutation	p.I109V	1

Copy number variation (CNV) of TUFM
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across TUFM
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
75090	STAD	TCGA-CD-5813-01A	CHD4	chr12	6687648	-	TUFM	chr16	28854445	-
75090	N/A	AV702479	HFM1	chr1	91852921	-	TUFM	chr16	28855144	-
75090	N/A	CF141674	P2RY8	chrY	1538635	+	TUFM	chr16	28864853	-
75090	N/A	BC023617	PRELID1P1	chr6	126964621	-	TUFM	chr16	28856140	-
75090	N/A	BQ063625	RNF40	chr16	30785478	+	TUFM	chr16	28857273	-
95431	N/A	EC543892	TUFM	chr16	28855777	-	DANCR	chr4	53580266	+
95431	N/A	AA514249	TUFM	chr16	28854237	+	NRBP2	chr8	144917117	+
95431	N/A	BQ063558	TUFM	chr16	28857291	-	RPS9	chr19	54705436	+
102368	N/A	CS190625	TUFM	chr16	28856764	-	USP4	chr3	49331866	-
95431	N/A	CA495305	TUFM	chr16	28854197	-	VSNL1	chr2	17800958	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRP	TUFM	0.000112447382311277	0.0031
LIHC	TUFM	0.000238366035478827	0.0064
HNSC	TUFM	0.000976739515507606	0.025

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	TUFM	0.0391928910757691	1
LUSC	TUFM	0.00128089890055036	0.041
THCA	TUFM	0.000537245377865002	0.018
KIRC	TUFM	0.00847550660100301	0.25
KIRP	TUFM	0.00239614068536167	0.074
LGG	TUFM	0.0371182643013452	1
PAAD	TUFM	0.0076748450554972	0.23
OV	TUFM	0.0385075011109948	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C1857682	Combined Oxidative Phosphorylation Deficiency 4	4	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
C0546837	Malignant neoplasm of esophagus	1	CTD_human