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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: VIM (NCBI Gene ID:7431)

Gene Summary

Gene Summary

Gene Information	Gene Name: VIM
	Gene ID: 7431
	Gene Symbol	VIM
	Gene ID	7431
	Gene Name	vimentin
	Synonyms	-
	Cytomap	10p13
	Type of Gene	protein-coding
	Description	vimentinepididymis secretory sperm binding protein
	Modification date	20200327
	UniProtAcc	P08670

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0045727	Positive regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
VIM	(355.7 - 733]

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Translation Studies in PubMed

We searched PubMed using 'VIM[title] AND translation [title] AND human.'

Gene	Title	PMID
VIM	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000224237	17272648	17272709	Frame-shift
ENST00000544301	17272648	17272709	Frame-shift
ENST00000224237	17275585	17275681	In-frame
ENST00000544301	17275585	17275681	In-frame
ENST00000224237	17276691	17276817	In-frame
ENST00000544301	17276691	17276817	In-frame
ENST00000224237	17277167	17277388	Frame-shift
ENST00000544301	17277167	17277388	Frame-shift
ENST00000224237	17277844	17277888	Frame-shift
ENST00000544301	17277844	17277888	Frame-shift
ENST00000224237	17278292	17278378	Frame-shift
ENST00000544301	17278292	17278378	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000224237	17275585	17275681	1885	770	865	466	208	240
ENST00000544301	17275585	17275681	2145	1038	1133	466	208	240
ENST00000224237	17276691	17276817	1885	1028	1153	466	294	336
ENST00000544301	17276691	17276817	2145	1296	1421	466	294	336

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KICH	VIM	1.18889542437608	0.000429689884185791
COAD	VIM	1.23114693833419	0.006689190864563
LUAD	VIM	-2.54734357972954	2.06541148982154e-09
BRCA	VIM	-4.84615696279344	3.20876214170436e-22

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
PRAD	VIM	-0.042128166	0.002239551

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with VIM (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
BLCA	Cell metabolism gene	VIM	GNG2	0.824253135	8.66E-107
BLCA	CGC	VIM	PDGFRB	0.844082081	7.95E-117
BLCA	IUPHAR	VIM	LRRC32	0.806002982	1.31E-98
BLCA	IUPHAR	VIM	PDGFRB	0.844082081	7.95E-117
BLCA	Kinase	VIM	PDGFRB	0.844082081	7.95E-117
BLCA	TF	VIM	HIC1	0.80514188	3.04E-98
BLCA	TF	VIM	ZEB2	0.847085786	1.81E-118
BLCA	TSG	VIM	HIC1	0.80514188	3.04E-98
BLCA	TSG	VIM	SPARC	0.813546647	7.02E-102
COAD	Cell metabolism gene	VIM	CAV1	0.802864315	1.92E-75
COAD	Cell metabolism gene	VIM	TUBB6	0.804214832	7.04E-76
COAD	Cell metabolism gene	VIM	PRELP	0.804217744	7.02E-76
COAD	Cell metabolism gene	VIM	ARSI	0.804313228	6.54E-76
COAD	Cell metabolism gene	VIM	TUSC3	0.805792838	2.16E-76
COAD	Cell metabolism gene	VIM	PIK3R5	0.81081547	4.66E-78
COAD	Cell metabolism gene	VIM	ST3GAL6	0.812080593	1.74E-78
COAD	Cell metabolism gene	VIM	HSD11B1	0.813346666	6.45E-79
COAD	Cell metabolism gene	VIM	PDE1A	0.820934243	1.43E-81
COAD	Cell metabolism gene	VIM	NPR1	0.820984714	1.37E-81
COAD	Cell metabolism gene	VIM	LUM	0.827139887	7.74E-84
COAD	Cell metabolism gene	VIM	GNG11	0.832353629	8.20E-86
COAD	Cell metabolism gene	VIM	CHST11	0.833607537	2.68E-86
COAD	Cell metabolism gene	VIM	ELOVL4	0.834150479	1.65E-86
COAD	Cell metabolism gene	VIM	CHST15	0.835550625	4.67E-87
COAD	Cell metabolism gene	VIM	GUCY1B3	0.842204686	9.76E-90
COAD	Cell metabolism gene	VIM	GUCY1A3	0.84699381	9.62E-92
COAD	Cell metabolism gene	VIM	AOC3	0.85079831	2.18E-93
COAD	Cell metabolism gene	VIM	PDE1B	0.850846084	2.08E-93
COAD	Cell metabolism gene	VIM	A2M	0.867725364	2.67E-101
COAD	Cell metabolism gene	VIM	GGT5	0.871677266	2.64E-103
COAD	Cell metabolism gene	VIM	GFPT2	0.879893428	1.07E-107
COAD	Cell metabolism gene	VIM	DCN	0.885824953	4.51E-111
COAD	Cell metabolism gene	VIM	SDC2	0.889049878	5.49E-113
COAD	Cell metabolism gene	VIM	BCAT1	0.893328475	1.27E-115
COAD	Cell metabolism gene	VIM	GPC6	0.904998064	2.04E-123
COAD	Cell metabolism gene	VIM	GNB4	0.928359907	1.33E-142
COAD	CGC	VIM	LYL1	0.803226115	1.47E-75
COAD	CGC	VIM	RUNX1T1	0.813187772	7.31E-79
COAD	CGC	VIM	EBF1	0.816927427	3.73E-80
COAD	CGC	VIM	PDCD1LG2	0.819002841	6.96E-81
COAD	CGC	VIM	ZEB1	0.827956617	3.84E-84
COAD	CGC	VIM	FLT4	0.83166463	1.51E-85
COAD	CGC	VIM	CHST11	0.833607537	2.68E-86
COAD	CGC	VIM	CSF1R	0.835292259	5.89E-87
COAD	CGC	VIM	MITF	0.846616569	1.39E-91
COAD	CGC	VIM	GAS7	0.855041654	2.82E-95
COAD	CGC	VIM	FCGR2B	0.857452806	2.24E-96
COAD	CGC	VIM	MAF	0.860443192	9.08E-98
COAD	CGC	VIM	FGFR1	0.862944354	5.86E-99
COAD	CGC	VIM	FLI1	0.864897218	6.65E-100
COAD	CGC	VIM	MSN	0.865859365	2.25E-100
COAD	CGC	VIM	ERG	0.86984562	2.28E-102
COAD	CGC	VIM	MYO5A	0.874962978	5.04E-105
COAD	CGC	VIM	DDR2	0.876282491	9.96E-106
COAD	CGC	VIM	AKT3	0.879956647	9.87E-108
COAD	CGC	VIM	FBLN2	0.883508546	9.86E-110
COAD	CGC	VIM	ZNF521	0.895587928	4.66E-117
COAD	CGC	VIM	MAFB	0.896105568	2.16E-117
COAD	Epifactor	VIM	SNAI2	0.86741784	3.80E-101
COAD	IUPHAR	VIM	SV2A	0.80047297	1.11E-74
COAD	IUPHAR	VIM	FCER1G	0.801171457	6.67E-75
COAD	IUPHAR	VIM	C5AR1	0.802226779	3.07E-75
COAD	IUPHAR	VIM	CD33	0.805752432	2.22E-76
COAD	IUPHAR	VIM	TUSC3	0.805792838	2.16E-76
COAD	IUPHAR	VIM	CTSK	0.806006421	1.84E-76
COAD	IUPHAR	VIM	DPEP2	0.806359862	1.41E-76
COAD	IUPHAR	VIM	PKD2	0.806804176	1.01E-76
COAD	IUPHAR	VIM	CD86	0.807133715	7.83E-77
COAD	IUPHAR	VIM	GPR68	0.808060299	3.87E-77
COAD	IUPHAR	VIM	GRID1	0.809194676	1.63E-77
COAD	IUPHAR	VIM	ABCC9	0.80938558	1.40E-77
COAD	IUPHAR	VIM	PIK3R5	0.81081547	4.66E-78
COAD	IUPHAR	VIM	P2RX7	0.81081898	4.64E-78
COAD	IUPHAR	VIM	HSD11B1	0.813346666	6.45E-79
COAD	IUPHAR	VIM	DCLK1	0.81600184	7.84E-80
COAD	IUPHAR	VIM	TRPC6	0.81758631	2.20E-80
COAD	IUPHAR	VIM	GPR1	0.819508654	4.61E-81
COAD	IUPHAR	VIM	GPR162	0.819883387	3.39E-81
COAD	IUPHAR	VIM	HCK	0.820306487	2.40E-81
COAD	IUPHAR	VIM	PDE1A	0.820934243	1.43E-81
COAD	IUPHAR	VIM	NPR1	0.820984714	1.37E-81
COAD	IUPHAR	VIM	CALCRL	0.822954044	2.67E-82
COAD	IUPHAR	VIM	NR3C1	0.823012607	2.55E-82
COAD	IUPHAR	VIM	HTR2A	0.825493101	3.16E-83
COAD	IUPHAR	VIM	GJA5	0.825673081	2.71E-83
COAD	IUPHAR	VIM	C3AR1	0.826769019	1.06E-83
COAD	IUPHAR	VIM	CD14	0.826910637	9.42E-84
COAD	IUPHAR	VIM	MRGPRF	0.827306742	6.71E-84
COAD	IUPHAR	VIM	ITGA5	0.828099022	3.39E-84
COAD	IUPHAR	VIM	FGR	0.828116199	3.34E-84
COAD	IUPHAR	VIM	TBXA2R	0.829607028	9.18E-85
COAD	IUPHAR	VIM	ITGB2	0.830222149	5.36E-85
COAD	IUPHAR	VIM	FLT4	0.83166463	1.51E-85
COAD	IUPHAR	VIM	KCND2	0.8320472	1.08E-85
COAD	IUPHAR	VIM	CSF1R	0.835292259	5.89E-87
COAD	IUPHAR	VIM	LY96	0.835495189	4.91E-87
COAD	IUPHAR	VIM	GPR176	0.836295242	2.37E-87
COAD	IUPHAR	VIM	LAIR1	0.837073252	1.17E-87
COAD	IUPHAR	VIM	OSMR	0.84330787	3.41E-90
COAD	IUPHAR	VIM	ADAMTS10	0.845723619	3.32E-91
COAD	IUPHAR	VIM	TEK	0.84823476	2.83E-92
COAD	IUPHAR	VIM	SLC22A17	0.848301645	2.65E-92
COAD	IUPHAR	VIM	PTPRM	0.848549925	2.07E-92
COAD	IUPHAR	VIM	CYP7B1	0.850067942	4.55E-93
COAD	IUPHAR	VIM	MAP3K12	0.850263112	3.74E-93
COAD	IUPHAR	VIM	AOC3	0.85079831	2.18E-93
COAD	IUPHAR	VIM	PDE1B	0.850846084	2.08E-93
COAD	IUPHAR	VIM	MMP2	0.851151124	1.53E-93
COAD	IUPHAR	VIM	PTGIR	0.851731389	8.49E-94
COAD	IUPHAR	VIM	ATP10A	0.853168535	1.96E-94
COAD	IUPHAR	VIM	CDK14	0.854218734	6.63E-95
COAD	IUPHAR	VIM	TRPV2	0.860191906	1.19E-97
COAD	IUPHAR	VIM	FGFR1	0.862944354	5.86E-99
COAD	IUPHAR	VIM	AEBP1	0.864097911	1.63E-99
COAD	IUPHAR	VIM	STK32B	0.868711922	8.55E-102
COAD	IUPHAR	VIM	S1PR1	0.873249007	4.02E-104
COAD	IUPHAR	VIM	ITGAM	0.873758002	2.18E-104
COAD	IUPHAR	VIM	DDR2	0.876282491	9.96E-106
COAD	IUPHAR	VIM	AKT3	0.879956647	9.87E-108
COAD	IUPHAR	VIM	IL1R1	0.880366835	5.84E-108
COAD	IUPHAR	VIM	TIE1	0.888261762	1.63E-112
COAD	IUPHAR	VIM	AXL	0.895786273	3.48E-117
COAD	IUPHAR	VIM	C1S	0.897777196	1.76E-118
COAD	IUPHAR	VIM	C1R	0.903022186	4.99E-122
COAD	IUPHAR	VIM	NRP1	0.903048706	4.79E-122
COAD	IUPHAR	VIM	ATP8B2	0.908685692	4.30E-126
COAD	Kinase	VIM	DCLK1	0.81600184	7.84E-80
COAD	Kinase	VIM	HCK	0.820306487	2.40E-81
COAD	Kinase	VIM	NPR1	0.820984714	1.37E-81
COAD	Kinase	VIM	FGR	0.828116199	3.34E-84
COAD	Kinase	VIM	FLT4	0.83166463	1.51E-85
COAD	Kinase	VIM	CSF1R	0.835292259	5.89E-87
COAD	Kinase	VIM	TEK	0.84823476	2.83E-92
COAD	Kinase	VIM	MAP3K12	0.850263112	3.74E-93
COAD	Kinase	VIM	CDK14	0.854218734	6.63E-95
COAD	Kinase	VIM	FGFR1	0.862944354	5.86E-99
COAD	Kinase	VIM	STK32B	0.868711922	8.55E-102
COAD	Kinase	VIM	DDR2	0.876282491	9.96E-106
COAD	Kinase	VIM	AKT3	0.879956647	9.87E-108
COAD	Kinase	VIM	TIE1	0.888261762	1.63E-112
COAD	Kinase	VIM	AXL	0.895786273	3.48E-117
COAD	TF	VIM	TRPS1	0.803148527	1.55E-75
COAD	TF	VIM	LYL1	0.803226115	1.47E-75
COAD	TF	VIM	EBF1	0.816927427	3.73E-80
COAD	TF	VIM	NR3C1	0.823012607	2.55E-82
COAD	TF	VIM	GLI2	0.824304393	8.62E-83
COAD	TF	VIM	MEIS1	0.824636293	6.52E-83
COAD	TF	VIM	SOX17	0.824697902	6.18E-83
COAD	TF	VIM	ZIK1	0.827647448	5.01E-84
COAD	TF	VIM	ZEB1	0.827956617	3.84E-84
COAD	TF	VIM	MEIS3	0.829030243	1.52E-84
COAD	TF	VIM	BCL6B	0.839959274	8.08E-89
COAD	TF	VIM	ZNF667	0.841975748	1.21E-89
COAD	TF	VIM	SPI1	0.844254708	1.38E-90
COAD	TF	VIM	TWIST2	0.845063862	6.31E-91
COAD	TF	VIM	MITF	0.846616569	1.39E-91
COAD	TF	VIM	MEOX2	0.847412014	6.37E-92
COAD	TF	VIM	HIC1	0.855028909	2.86E-95
COAD	TF	VIM	MAF	0.860443192	9.08E-98
COAD	TF	VIM	AEBP1	0.864097911	1.63E-99
COAD	TF	VIM	FLI1	0.864897218	6.65E-100
COAD	TF	VIM	SNAI2	0.86741784	3.80E-101
COAD	TF	VIM	TSHZ3	0.86757536	3.17E-101
COAD	TF	VIM	ZFPM2	0.869840033	2.30E-102
COAD	TF	VIM	ERG	0.86984562	2.28E-102
COAD	TF	VIM	DZIP1	0.877251202	2.99E-106
COAD	TF	VIM	BNC2	0.88967647	2.29E-113
COAD	TF	VIM	TCF4	0.889793458	1.95E-113
COAD	TF	VIM	ZNF521	0.895587928	4.66E-117
COAD	TF	VIM	MAFB	0.896105568	2.16E-117
COAD	TF	VIM	HLX	0.898628663	4.81E-119
COAD	TF	VIM	GLI3	0.903005646	5.13E-122
COAD	TF	VIM	ZEB2	0.928408198	1.19E-142
COAD	TSG	VIM	CAV1	0.802864315	1.92E-75
COAD	TSG	VIM	TAGLN	0.804673768	5.00E-76
COAD	TSG	VIM	PDLIM4	0.806042263	1.79E-76
COAD	TSG	VIM	CYGB	0.807528472	5.81E-77
COAD	TSG	VIM	MRVI1	0.812588685	1.17E-78
COAD	TSG	VIM	SFRP2	0.813592853	5.31E-79
COAD	TSG	VIM	TGFB1	0.814567522	2.46E-79
COAD	TSG	VIM	CDH5	0.823317192	1.97E-82
COAD	TSG	VIM	ITGA5	0.828099022	3.39E-84
COAD	TSG	VIM	FBLN1	0.828397063	2.62E-84
COAD	TSG	VIM	EHD3	0.829573011	9.45E-85
COAD	TSG	VIM	UBE2QL1	0.829857599	7.38E-85
COAD	TSG	VIM	THBD	0.834526533	1.18E-86
COAD	TSG	VIM	DLC1	0.83521489	6.32E-87
COAD	TSG	VIM	HTRA1	0.839515893	1.22E-88
COAD	TSG	VIM	BCL6B	0.839959274	8.08E-89
COAD	TSG	VIM	SPI1	0.844254708	1.38E-90
COAD	TSG	VIM	SPARCL1	0.844622204	9.66E-91
COAD	TSG	VIM	TWIST2	0.845063862	6.31E-91
COAD	TSG	VIM	CMTM3	0.853501424	1.39E-94
COAD	TSG	VIM	PRICKLE1	0.854511137	4.90E-95
COAD	TSG	VIM	DFNA5	0.8547177	3.96E-95
COAD	TSG	VIM	HIC1	0.855028909	2.86E-95
COAD	TSG	VIM	MCC	0.857951558	1.32E-96
COAD	TSG	VIM	GAS1	0.85868358	6.05E-97
COAD	TSG	VIM	BASP1	0.859476589	2.58E-97
COAD	TSG	VIM	PLEKHO1	0.868675355	8.92E-102
COAD	TSG	VIM	RASSF2	0.873907675	1.82E-104
COAD	TSG	VIM	DDR2	0.876282491	9.96E-106
COAD	TSG	VIM	DCN	0.885824953	4.51E-111
COAD	TSG	VIM	TCF4	0.889793458	1.95E-113
ESCA	TF	VIM	ZEB2	0.82274041	1.76E-49
ESCA	TSG	VIM	IGFBP7	0.807850556	2.03E-46
KICH	Epifactor	VIM	APOBEC3C	0.807543552	4.07E-22
KICH	Epifactor	VIM	SNAI2	0.810733368	2.08E-22
KICH	IUPHAR	VIM	ADAM19	0.808808987	3.13E-22
KICH	IUPHAR	VIM	IFI16	0.843260231	1.01E-25
KICH	TF	VIM	SNAI2	0.810733368	2.08E-22
KICH	TF	VIM	GLI3	0.814479422	9.35E-23
KICH	TSG	VIM	IFI16	0.843260231	1.01E-25
LGG	Cell metabolism gene	VIM	GNG5	0.810961369	5.35E-125
LIHC	TF	VIM	HOXB2	0.800467381	1.25E-95
LUSC	Cell metabolism gene	VIM	GNAI2	0.821754742	1.09E-136
LUSC	CGC	VIM	FLI1	0.817309516	4.94E-134
LUSC	IUPHAR	VIM	ATP10A	0.834948737	4.92E-145
LUSC	IUPHAR	VIM	TRPV2	0.844092456	2.90E-151
LUSC	TF	VIM	MEF2C	0.801000106	7.16E-125
LUSC	TF	VIM	ETS1	0.802362332	1.33E-125
LUSC	TF	VIM	FLI1	0.817309516	4.94E-134
LUSC	TF	VIM	ZEB2	0.850400503	8.44E-156
LUSC	TSG	VIM	STARD13	0.830117785	6.77E-142
PAAD	TSG	VIM	BASP1	0.819641406	1.17E-45
PRAD	IUPHAR	VIM	MMP2	0.804078338	7.43E-126
PRAD	TSG	VIM	GSN	0.807768442	7.08E-128
PRAD	TSG	VIM	IGFBP7	0.812884096	9.41E-131
READ	Cell metabolism gene	VIM	A2M	0.800519705	1.22E-24
READ	Cell metabolism gene	VIM	NPR2	0.801392948	9.97E-25
READ	Cell metabolism gene	VIM	PTGIS	0.803737229	5.77E-25
READ	Cell metabolism gene	VIM	WWTR1	0.808754344	1.74E-25
READ	Cell metabolism gene	VIM	GPC6	0.833698256	2.57E-28
READ	Cell metabolism gene	VIM	LUM	0.835212953	1.67E-28
READ	Cell metabolism gene	VIM	NPR1	0.835645124	1.47E-28
READ	Cell metabolism gene	VIM	GUCY1A3	0.846054497	6.71E-30
READ	Cell metabolism gene	VIM	GFPT2	0.856453294	2.41E-31
READ	Cell metabolism gene	VIM	GUCY1B3	0.858902281	1.06E-31
READ	Cell metabolism gene	VIM	DCN	0.866339614	7.95E-33
READ	Cell metabolism gene	VIM	SDC2	0.887332573	2.08E-36
READ	Cell metabolism gene	VIM	GNB4	0.923602727	1.09E-44
READ	CGC	VIM	GLI1	0.800373542	1.26E-24
READ	CGC	VIM	PRRX1	0.80599199	3.38E-25
READ	CGC	VIM	MSN	0.807854409	2.17E-25
READ	CGC	VIM	WWTR1	0.808754344	1.74E-25
READ	CGC	VIM	FLT4	0.80902858	1.63E-25
READ	CGC	VIM	FCGR2B	0.812165035	7.58E-26
READ	CGC	VIM	EPHA3	0.814571426	4.16E-26
READ	CGC	VIM	GAS7	0.831606628	4.62E-28
READ	CGC	VIM	RUNX1T1	0.833149448	3.00E-28
READ	CGC	VIM	ZEB1	0.835919004	1.36E-28
READ	CGC	VIM	ZNF521	0.840873406	3.21E-29
READ	CGC	VIM	FLI1	0.841929016	2.34E-29
READ	CGC	VIM	CSF1R	0.848161666	3.49E-30
READ	CGC	VIM	DDR2	0.859953114	7.43E-32
READ	CGC	VIM	MYO5A	0.865981931	9.04E-33
READ	CGC	VIM	MAF	0.870539517	1.72E-33
READ	CGC	VIM	FBLN2	0.877322942	1.28E-34
READ	CGC	VIM	MITF	0.88329455	1.15E-35
READ	CGC	VIM	MAFB	0.884401719	7.25E-36
READ	CGC	VIM	FGFR1	0.884467877	7.05E-36
READ	CGC	VIM	AKT3	0.885711048	4.17E-36
READ	Epifactor	VIM	PRDM6	0.800171552	1.32E-24
READ	Epifactor	VIM	SNAI2	0.842035629	2.27E-29
READ	IUPHAR	VIM	NPR2	0.801392948	9.97E-25
READ	IUPHAR	VIM	GLRB	0.802756119	7.26E-25
READ	IUPHAR	VIM	MNDA	0.803359989	6.30E-25
READ	IUPHAR	VIM	PTGIS	0.803737229	5.77E-25
READ	IUPHAR	VIM	NR3C1	0.805050039	4.23E-25
READ	IUPHAR	VIM	MAP3K12	0.805800244	3.54E-25
READ	IUPHAR	VIM	GPR1	0.806710622	2.85E-25
READ	IUPHAR	VIM	C5AR1	0.806930679	2.70E-25
READ	IUPHAR	VIM	FLT4	0.80902858	1.63E-25
READ	IUPHAR	VIM	P2RX7	0.809290088	1.53E-25
READ	IUPHAR	VIM	HAVCR2	0.810754752	1.07E-25
READ	IUPHAR	VIM	CD86	0.811736605	8.42E-26
READ	IUPHAR	VIM	FPR3	0.81188849	8.11E-26
READ	IUPHAR	VIM	CD33	0.814194822	4.57E-26
READ	IUPHAR	VIM	SLC6A17	0.814486822	4.25E-26
READ	IUPHAR	VIM	KCND2	0.814497515	4.24E-26
READ	IUPHAR	VIM	EPHA3	0.814571426	4.16E-26
READ	IUPHAR	VIM	DCLK1	0.817881493	1.80E-26
READ	IUPHAR	VIM	ADAMTS10	0.820556062	9.04E-27
READ	IUPHAR	VIM	LY96	0.822086945	6.06E-27
READ	IUPHAR	VIM	DPEP2	0.82639956	1.92E-27
READ	IUPHAR	VIM	C3AR1	0.827178182	1.56E-27
READ	IUPHAR	VIM	PKD2	0.82782125	1.31E-27
READ	IUPHAR	VIM	OSMR	0.829001101	9.49E-28
READ	IUPHAR	VIM	FZD4	0.831509461	4.74E-28
READ	IUPHAR	VIM	GPR176	0.833089794	3.05E-28
READ	IUPHAR	VIM	ITGB2	0.833608333	2.63E-28
READ	IUPHAR	VIM	ATP10A	0.834790224	1.88E-28
READ	IUPHAR	VIM	NPR1	0.835645124	1.47E-28
READ	IUPHAR	VIM	IL1R1	0.836755034	1.07E-28
READ	IUPHAR	VIM	AEBP1	0.836932414	1.02E-28
READ	IUPHAR	VIM	ITGA5	0.838025185	7.42E-29
READ	IUPHAR	VIM	LAIR1	0.838889726	5.76E-29
READ	IUPHAR	VIM	SLC22A17	0.847129145	4.81E-30
READ	IUPHAR	VIM	CSF1R	0.848161666	3.49E-30
READ	IUPHAR	VIM	PTPRM	0.853092688	7.27E-31
READ	IUPHAR	VIM	C1S	0.854952717	3.96E-31
READ	IUPHAR	VIM	TRPV2	0.855375946	3.45E-31
READ	IUPHAR	VIM	C1R	0.857965569	1.46E-31
READ	IUPHAR	VIM	DDR2	0.859953114	7.43E-32
READ	IUPHAR	VIM	TIE1	0.863861231	1.92E-32
READ	IUPHAR	VIM	ITGAM	0.868935842	3.10E-33
READ	IUPHAR	VIM	CDK14	0.870880641	1.51E-33
READ	IUPHAR	VIM	NRP1	0.882432816	1.64E-35
READ	IUPHAR	VIM	FGFR1	0.884467877	7.05E-36
READ	IUPHAR	VIM	AKT3	0.885711048	4.17E-36
READ	IUPHAR	VIM	ATP8B2	0.904910102	5.30E-40
READ	IUPHAR	VIM	AXL	0.910797126	2.30E-41
READ	Kinase	VIM	NPR2	0.801392948	9.97E-25
READ	Kinase	VIM	MAP3K12	0.805800244	3.54E-25
READ	Kinase	VIM	FLT4	0.80902858	1.63E-25
READ	Kinase	VIM	EPHA3	0.814571426	4.16E-26
READ	Kinase	VIM	DCLK1	0.817881493	1.80E-26
READ	Kinase	VIM	NPR1	0.835645124	1.47E-28
READ	Kinase	VIM	CSF1R	0.848161666	3.49E-30
READ	Kinase	VIM	DDR2	0.859953114	7.43E-32
READ	Kinase	VIM	TIE1	0.863861231	1.92E-32
READ	Kinase	VIM	CDK14	0.870880641	1.51E-33
READ	Kinase	VIM	FGFR1	0.884467877	7.05E-36
READ	Kinase	VIM	AKT3	0.885711048	4.17E-36
READ	Kinase	VIM	AXL	0.910797126	2.30E-41
READ	TF	VIM	PRDM6	0.800171552	1.32E-24
READ	TF	VIM	GLI1	0.800373542	1.26E-24
READ	TF	VIM	NR3C1	0.805050039	4.23E-25
READ	TF	VIM	PRRX1	0.80599199	3.38E-25
READ	TF	VIM	NFATC1	0.818265304	1.63E-26
READ	TF	VIM	ZFHX4	0.81927698	1.26E-26
READ	TF	VIM	MEIS3	0.820380998	9.46E-27
READ	TF	VIM	TSHZ2	0.820515743	9.14E-27
READ	TF	VIM	MEF2C	0.835381906	1.59E-28
READ	TF	VIM	ZEB1	0.835919004	1.36E-28
READ	TF	VIM	PEG3	0.836743405	1.08E-28
READ	TF	VIM	AEBP1	0.836932414	1.02E-28
READ	TF	VIM	ZNF521	0.840873406	3.21E-29
READ	TF	VIM	SPI1	0.841754045	2.47E-29
READ	TF	VIM	FLI1	0.841929016	2.34E-29
READ	TF	VIM	SNAI2	0.842035629	2.27E-29
READ	TF	VIM	ZNF667	0.854475361	4.63E-31
READ	TF	VIM	GLI2	0.854943137	3.97E-31
READ	TF	VIM	HLX	0.858730765	1.13E-31
READ	TF	VIM	HIC1	0.862972785	2.62E-32
READ	TF	VIM	MAF	0.870539517	1.72E-33
READ	TF	VIM	ZFPM2	0.871304477	1.29E-33
READ	TF	VIM	BNC2	0.874731102	3.52E-34
READ	TF	VIM	GLI3	0.876075334	2.09E-34
READ	TF	VIM	TCF4	0.88226957	1.76E-35
READ	TF	VIM	MITF	0.88329455	1.15E-35
READ	TF	VIM	MAFB	0.884401719	7.25E-36
READ	TF	VIM	TSHZ3	0.884582402	6.72E-36
READ	TF	VIM	DZIP1	0.885059141	5.50E-36
READ	TF	VIM	ZEB2	0.900110026	5.91E-39
READ	TSG	VIM	RNF180	0.800328109	1.28E-24
READ	TSG	VIM	GLI1	0.800373542	1.26E-24
READ	TSG	VIM	PDGFRL	0.803920555	5.53E-25
READ	TSG	VIM	THBD	0.809057103	1.62E-25
READ	TSG	VIM	SFRP2	0.810848844	1.05E-25
READ	TSG	VIM	BASP1	0.81163942	8.62E-26
READ	TSG	VIM	EPHA3	0.814571426	4.16E-26
READ	TSG	VIM	DKK3	0.816239642	2.74E-26
READ	TSG	VIM	AKAP12	0.820747547	8.60E-27
READ	TSG	VIM	SLIT2	0.822330501	5.69E-27
READ	TSG	VIM	CMTM3	0.822791451	5.04E-27
READ	TSG	VIM	RASSF8	0.828949791	9.62E-28
READ	TSG	VIM	MCC	0.832624713	3.47E-28
READ	TSG	VIM	PEG3	0.836743405	1.08E-28
READ	TSG	VIM	ITGA5	0.838025185	7.42E-29
READ	TSG	VIM	SPI1	0.841754045	2.47E-29
READ	TSG	VIM	DLC1	0.849653869	2.18E-30
READ	TSG	VIM	RASSF2	0.850861311	1.49E-30
READ	TSG	VIM	GAS1	0.852892974	7.75E-31
READ	TSG	VIM	TGFB1	0.857547739	1.68E-31
READ	TSG	VIM	DDR2	0.859953114	7.43E-32
READ	TSG	VIM	HIC1	0.862972785	2.62E-32
READ	TSG	VIM	PRICKLE1	0.865295618	1.16E-32
READ	TSG	VIM	DCN	0.866339614	7.95E-33
READ	TSG	VIM	TCF4	0.88226957	1.76E-35
STAD	IUPHAR	VIM	C1R	0.80283812	1.11E-102
STAD	TF	VIM	ZEB2	0.819908745	1.39E-110
TGCT	IUPHAR	VIM	SFXN3	0.829188225	9.67E-41

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
COAD	VIM	FSCN1	-1.05024165293072	0.000109195709228516
KICH	VIM	CASP3	-1.33579752215497	0.000187873840332031
KICH	VIM	CASP8	2.62594462743656	0.000187873840332031
LIHC	VIM	HSP90AA1	-1.87137739671902	0.0003817245773207
HNSC	VIM	DES	-1.35535151973049	0.00302236390302824
BRCA	VIM	CASP8	1.38808890309971	0.00337620350321977
ESCA	VIM	DES	-1.55487478759628	0.0048828125
CHOL	VIM	FSCN1	-7.3631077981622	0.02734375
LUAD	VIM	AKT1	-4.53714460696341	0.0301695351050489
READ	VIM	CASP7	-1.09019031382838	0.03125
ESCA	VIM	HSP90AA1	-2.95407832928575	0.0322265625
BLCA	VIM	VCP	1.64346607685126	0.040130615234375
KICH	VIM	VCP	-1.0767074679478	0.0421501994132996
COAD	VIM	DES	-1.17889525806753	1.1056661605835e-05
BRCA	VIM	HSP90AA1	2.1978220577015	1.13731762084626e-08
KIRC	VIM	CASP3	-1.13788607606139	1.47934674983518e-09
BRCA	VIM	AURKB	-5.02951949881606	1.53964024974447e-30
HNSC	VIM	FSCN1	1.71494233965843	1.59161572810263e-11
LIHC	VIM	DES	1.31836822070384	1.81873379105532e-05
BLCA	VIM	DES	-1.67964425916332	1.9073486328125e-05
KIRP	VIM	CASP3	-1.47815796439668	2.00234353542328e-08
COAD	VIM	CASP7	-1.32514960363704	2.08616256713867e-07
LUAD	VIM	VCP	-3.53792153271573	2.3648912015911e-05
LUSC	VIM	STAT3	-1.0616935152134	2.622390634108e-05
STAD	VIM	CASP8	2.67526976152624	2.98023223876953e-07
LUSC	VIM	CASP7	-1.29093498862534	3.09303724812157e-05
KIRC	VIM	STAT3	-1.71331361645034	3.24635122520647e-05
KIRP	VIM	AURKB	-1.44890441039492	3.25962901115418e-08
PRAD	VIM	VCP	1.47137253545938	3.48152859299693e-07
STAD	VIM	HSP90AA1	-1.65705125430285	3.51201742887497e-06
LUAD	VIM	DES	-3.71054109477077	3.59910232594763e-11
PRAD	VIM	CASP8	-1.40179731553716	3.77428293642232e-05
HNSC	VIM	AURKB	3.44852701959941	4.62705429526978e-10
KIRC	VIM	AURKB	-1.32624311879856	7.43306349049898e-12
LIHC	VIM	AURKB	-2.85194459305443	7.79049220721842e-10
COAD	VIM	AURKB	1.18235350007823	8.15689563751222e-05
KIRC	VIM	FSCN1	-2.03696240762246	9.96528734460538e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with VIM

ALS2CR11, KAT7, TCHP, ABLIM1, NIF3L1, NOC4L, FAM107A, KRT20, GFAP, KIAA0408, APIP, TUBGCP4, PDLIM1, PSMA1, GOPC, RIBC2, DCTN1, RAB8B, BRD1, DPPA4, IVNS1ABP, SH3YL1, SLC27A6, YAE1D1, FABP4, HABP4, TRIOBP, LOR, MAFG, DIS3L2, NFATC2, PSME1, SDCCAG3, STX1A, SYN1, TNFRSF14, TRIM28, VIM, XRCC4, SRRT, BHLHE40, CASP8, CREB1, HMG20B, KIF15, MAN2A2, MRPL44, CRCT1, SERBP1, RABAC1, RAD51, SIRT6, SUMO3, SUMO2, TTR, LRIF1, FUBP1, PUF60, SLC25A6, ATN1, YWHAZ, OSBP2, BFSP1, TXN, PKN1, PKP1, DSP, MEN1, CDH5, MICAL1, UPP1, UPP2, PLEC, NME2, ACTA1, SPTAN1, LMNB1, PPL, MGMT, SRRM2, HDAC1, TOX4, CBL, RYK, CD4, TJP1, YWHAQ, SPG20, YWHAG, GSK3B, UROD, FAM118B, CDKN1A, TNNT1, ANKRD35, APLP1, KARS, DGCR14, CRMP1, SH3GL1, PRPH, NR1H2, ANXA7, TSC22D1, GADD45A, TRIM16, ARRB1, ARRB2, SP1, NOD2, ISG15, FBXO25, CUL3, CDK2, CUL1, COPS5, CHD3, NEFL, SH3GL3, UTP14A, SETDB1, PSMD7, ZHX1, PPHLN1, PIAS4, HAP1, RBM48, ING5, ARMCX2, MYOC, LRRK2, AKT1, AKT2, RAD23B, RAD23A, APP, THOC3, THOC5, URGCP, PSMA2, PDIA3, RRP9, THOC2, YEATS4, THOC7, PSMB5, PSMA8, VPS33A, RCC2, UBR4, ZYX, PSMB2, NUDT21, CCT6A, TSGA10, EIF4A3, MAGOH, HNF1A, SMURF1, VCP, FN1, VCAM1, HTRA2, HCVgp1, ATF2, gag-pol, ITGA4, SVIL, CAPN1, PAN2, BAG3, PINK1, TXN2, POLR1C, GRB2, RPA1, TAB2, CASP3, CASP7, FBXO6, PARK2, EEF1D, FOXK1, COPS8, SERPINH1, ASB2, ASB9, ASB15, ASB16, STAU1, SPRTN, TRIM68, PLA2G2A, TP53, PA2G4, CHFR, PNMA5, CWF19L2, TXLNB, ALK, RNF2, ABCE1, PRMT8, LGALS3, HSPB1, NTRK1, BASP1, SCARNA22, PSMC5, CNTRL, XPO1, AHSA1, DDOST, NMT1, RPL12, RPS7, UBTF, NES, MTA1, FLOT1, PSIP1, NELFCD, NAT10, NUP133, XPNPEP3, C14orf169, SYNC, TRIM15, GAN, TRIM29, MCM2, MCM5, SNW1, CDC5L, ITGB3, PLA2G4A, RC3H1, CDC73, AHR, HYPK, USP14, PPM1B, STYXL1, NEFM, DES, INA, RSPRY1, UBR1, EPPK1, IDE, GXYLT1, ZYG11B, PRMT1, GLB1, CTSA, HSPA5, DFNB31, UBE2N, TCTEX1D2, DYNLT1, CYLD, SMARCB1, MCPH1, HEY1, TWIST1, TES, MTF1, BRAF, UL17, CFTR, CLEC14A, TRIM14, MAPK6, TMPO, PTCH1, ZNF217, SQSTM1, CUL4B, UBE2M, PRPF8, EFTUD2, AAR2, RPTOR, PPP5C, RNF4, CHD4, LARP7, RNF31, TUBA1C, CALCOCO2, ZUFSP, ACTG1, HEXIM1, EGFR, PPT1, AGR2, NEDD9, RECQL4, STUB1, MYC, CDK9, Prkaa1, Prkab1, WDR76, HIST1H4A, HIST1H2BB, HIST1H2AB, NEK2, KRT17, METTL3, METTL14, WTAP, KIAA1429, SIRPA, PSMA3, ZBTB7A, ESR2, RBX1, ARMC12, CCND1, TET2, NR2C2, UBQLN2, PPP1CC, MTDH, UBE3C, ZFYVE21, OTUB2, AGRN, NHLRC2, ATXN3, VRK3, PSMD14, BIRC3, BRD7, ACE2, S, HTT, PPIA, GRIA4, LGALS14, KIF9, AES, BYSL, ARMC7, KIFC3, CBX8, PPP1R18, SCNM1, GEM, NFKBID, CT55, FAM161A, KRT75, TCEA2, IP6K1, ZNF572, STK19, MGC50722, XIAP, PLEKHA4, YAP1, TFCP2, FANCD2, NGB, LINC01554, IKBKB, NFKBIA, TUBB, NFKB1, SFPQ, BECN1, ULK1, ZC3H18, BLK, EMC2, SAMHD1, ANGPT2, GCFC2, RPS6, AMPD2, SPIN3, NIPAL3, XKR5, CD300LD, MEPCE, MAGEE2, KIF20B, LARS, IDI2-AS1, NEB, PTPRG, WEE1, ADRA1A, NLRP11, MAP2K5, RBM39, PTGIS, RUNDC3A, ZNF667, FAM69B, CEP128, CENPU, ASCC3, PROCA1, PPFIBP2, CNKSR2, DOCK10, CAMKK2, SENP7, STK31, SPEF2, SENP3, KIAA1551, ZNF148, ZNF888, LOC728637, DFFB, KRT18, KRT8, TIMP3, XKR6, PEX5L, AHCTF1, SYNGAP1, UACA, PTPN22, ANKRD55, MEGF10, MAP1LC3B, NEK4, DUX4, CIT, ANLN, AURKB, CHMP4B, ECT2, KIF14, KIF20A, KIF23, PRC1, PRNP, OCIAD1, USP15, NMRAL1, NDN, BRD4, NUPR1, TRIM21, CIC, UBR5, Apc2, BCAP31, LGALS9, nsp16, RNF208, EIF3F, RIN3, OGT, UFL1, DDRGK1, NR4A1, KRT19, AAK1, ABL2, ANKLE2, ARFGAP3, BICD1, BICD2, C1orf198, CAMSAP3, CC2D1A, CCDC85C, CCSER2, CEP131, CEP41, CEP85, AIM1, FAM83B, FAM83G, FAM83H, ADRBK1, HOOK1, IFFO1, IFT74, KIAA1671, KIF7, LASP1, LIMD1, LUZP1, LZTS2, MAPRE1, NAV1, OCRL, PAK4, PDLIM7, PIK3C2A, PLEKHG1, PLK1, RASSF8, RIPK2, RTN1, SACS, SIPA1L3, SLAIN1, SLAIN2, SNX4, SOGA1, SYNJ1, SYNJ2, SYNM, TEX9, TNIP1, TNRC6A, TRIM36, TRIM62, ARCN1, ARFGAP2, CCDC138, CCDC50, CCP110, CEP44, DNMBP, DOCK4, EIF4H, HGS, IRAK1, KIAA1217, LDHB, LMO7, LPP, MAP7D3, NEDD1, NSF, PATL1, PDLIM3, PDLIM5, PLEKHA5, PSMD12, RPAP2, RTCB, RTN3, SCYL2, SIPA1L2, SORBS1, TEX2, TNRC6B, TTF2, TTK, TWF1, FAM21C, TRIM37, FZR1, SYVN1, FXR1, FXR2, SHANK3, TSC1, NUDCD2, NAA40, BGLT3, NUMB, ZBTB2, CERS2, SCRIB, MBNL1, SSBP2, KLHL20, NCF1, SIK1, NRSN1, DKK2, UBE2U, CCR1, B3GNT2, CYP3A43, C3orf62, ATP6AP2, SARAF, RHBDD1, LY6D, CERS3, SSUH2, ACAT1, SMIM8, KLK10, EGFL8, CLCN2, C18orf21, TGOLN2, AGPAT1, PRKX, YIPF2, CPEB4, USP11, WBP2, BTF3, SEPT9, RC3H2, NXF1, PRPF6, EXOSC7, RBM22, WDR59, BAG4, PKP2, Dusp14, Elavl4, NLRP7, LHPP, RCHY1, KDM4C, SLFN11, nsp14, RB1CC1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
VIM	chr10	17270991	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
VIM	chr10	17271110	G	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
VIM	chr10	17271206	G	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
VIM	chr10	17271395	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
VIM	chr10	17271400	G	C	single_nucleotide_variant	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
VIM	chr10	17271434	TC	T	Deletion	Pathogenic/Likely_pathogenic	Developmental_cataract\|Cataract_30	SO:0001589\|frameshift_variant,SO:0001619\|non-coding_transcript_variant	SO:0001589\|frameshift_variant,SO:0001619\|non-coding_transcript_variant
VIM	chr10	17271444	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
VIM	chr10	17271520	G	T	single_nucleotide_variant	Benign	Cataract_30	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
VIM	chr10	17271588	C	A	single_nucleotide_variant	Uncertain_significance	Cataract_30	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
VIM	chr10	17271703	C	T	single_nucleotide_variant	Benign	Cataract_30	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
VIM	chr10	17271872	G	A	single_nucleotide_variant	Pathogenic	Cataract_30\|not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
VIM	chr10	17271889	G	C	single_nucleotide_variant	Uncertain_significance	Cataract_30	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
VIM	chr10	17271963	A	C	single_nucleotide_variant	Likely_benign	Cataract_30	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
VIM	chr10	17272106	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
VIM	chr10	17272374	G	GT	Duplication	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
VIM	chr10	17272510	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
VIM	chr10	17272622	C	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
VIM	chr10	17272708	A	G	single_nucleotide_variant	Uncertain_significance	Cataract_30	SO:0001583\|missense_variant	SO:0001583\|missense_variant
VIM	chr10	17272716	A	C	single_nucleotide_variant	Likely_benign	Cataract_30	SO:0001627\|intron_variant	SO:0001627\|intron_variant
VIM	chr10	17272903	A	AT	Duplication	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
VIM	chr10	17272903	AT	A	Deletion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
VIM	chr10	17275450	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
VIM	chr10	17275699	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
VIM	chr10	17275797	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
VIM	chr10	17275806	A	G	single_nucleotide_variant	Uncertain_significance	Cataract_30	SO:0001583\|missense_variant	SO:0001583\|missense_variant
VIM	chr10	17275822	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
VIM	chr10	17275855	G	T	single_nucleotide_variant	Benign	Cataract_30	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
VIM	chr10	17275861	C	T	single_nucleotide_variant	Benign	Cataract_30\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
VIM	chr10	17275927	C	G	single_nucleotide_variant	Benign/Likely_benign	Cataract_30\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
VIM	chr10	17275937	A	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
VIM	chr10	17276066	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
VIM	chr10	17276405	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
VIM	chr10	17276720	G	A	single_nucleotide_variant	Uncertain_significance	Cataract_30	SO:0001583\|missense_variant	SO:0001583\|missense_variant
VIM	chr10	17276796	A	G	single_nucleotide_variant	Likely_benign	Cataract_30	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
VIM	chr10	17276916	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
VIM	chr10	17277132	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
VIM	chr10	17277158	C	T	single_nucleotide_variant	Benign	Cataract_30\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
VIM	chr10	17277160	C	A	single_nucleotide_variant	Likely_benign	Cataract_30	SO:0001627\|intron_variant	SO:0001627\|intron_variant
VIM	chr10	17277193	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
VIM	chr10	17277300	C	T	single_nucleotide_variant	Uncertain_significance	Cataract_30	SO:0001583\|missense_variant	SO:0001583\|missense_variant
VIM	chr10	17277314	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
VIM	chr10	17277319	T	C	single_nucleotide_variant	Likely_pathogenic	syndrome_with_premature-aging	SO:0001583\|missense_variant	SO:0001583\|missense_variant
VIM	chr10	17277381	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
VIM	chr10	17277477	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
VIM	chr10	17277503	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
VIM	chr10	17277637	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
VIM	chr10	17278171	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
VIM	chr10	17279029	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
VIM	chr10	17279242	C	CTT	Duplication	Uncertain_significance	Cataract_30	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
VIM	chr10	17279325	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
VIM	chr10	17279517	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
VIM	chr10	17279562	G	T	single_nucleotide_variant	Benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
VIM	KIRP	chr10	17276732	17276732	C	G	Missense_Mutation	p.A308G	4
VIM	ESCA	chr10	17277328	17277328	A	C	Missense_Mutation	p.K390T	4
VIM	UCEC	chr10	17275604	17275604	C	G	Missense_Mutation	p.L215V	3
VIM	SKCM	chr10	17271887	17271887	G	A	Missense_Mutation	p.E156K	3
VIM	LIHC	chr10	17277863	17277863	A	T	Silent	p.P416P	3
VIM	KIRP	chr10	17278345	17278345	T	G	Silent	p.L442L	3
VIM	LIHC	chr10	17277863	17277863	A	T	Silent		3
VIM	PAAD	chr10	17277377	17277377	C	A	Silent	p.G406G	3
VIM	ESCA	chr10	17275912	17275912	A	C	Missense_Mutation	p.E288D	3
VIM	PAAD	chr10	17276772	17276772	A	G	Silent	p.R321R	3
VIM	BRCA	chr10	17278368	17278368	G	C	Missense_Mutation	p.R450T	3
VIM	ESCA	chr10	17277328	17277328	A	C	Missense_Mutation		3
VIM	LUAD	chr10	17275634	17275634	G	T	Nonsense_Mutation	p.E225*	3
VIM	UCEC	chr10	17277219	17277219	G	A	Missense_Mutation	p.E354K	3
VIM	LIHC	chr10	17278320	17278320	T	C	Missense_Mutation	p.V434A	3
VIM	BLCA	chr10	17277884	17277884	G	A	Silent		2
VIM	LUAD	chr10	17276749	17276749	C	T	Nonsense_Mutation	p.Q314*	2
VIM	BLCA	chr10	17277194	17277194	T	C	Silent	p.R345R	2
VIM	HNSC	chr10	17277251	17277251	C	A	Silent	p.R364R	2
VIM	STAD	chr10	17277193	17277193	G	A	Missense_Mutation	p.R345H	2
VIM	BLCA	chr10	17275816	17275816	C	T	Silent	p.I256I	2
VIM	PAAD	chr10	17276772	17276772	A	G	Silent		2
VIM	SKCM	chr10	17276783	17276783	C	T	Missense_Mutation	p.S325F	2
VIM	STAD	chr10	17276765	17276765	A	G	Missense_Mutation	p.Y319C	2
VIM	BLCA	chr10	17277378	17277378	G	A	Missense_Mutation	p.E407K	2
VIM	UCEC	chr10	17271740	17271740	C	T	Silent	p.L107	2
VIM	SKCM	chr10	17276785	17276785	C	T	Missense_Mutation	p.L326F	2
VIM	LUSC	chr10	17277176	17277176	C	A	Silent	p.S339S	2
VIM	STAD	chr10	17271775	17271775	C	T	Silent	p.I118I	2
VIM	UCEC	chr10	17271804	17271804	A	C	Missense_Mutation	p.N128T	2
VIM	SKCM	chr10	17278314	17278314	C	T	Missense_Mutation	p.P432L	2
VIM	STAD	chr10	17271880	17271880	G	A	Silent	p.E153E	2
VIM	LIHC	chr10	17277885	17277885	A	T	Missense_Mutation		2
VIM	UCEC	chr10	17272668	17272669	-	AG	Frame_Shift_Ins	p.E198fs	2
VIM	HNSC	chr10	17275622	17275622	G	C	Missense_Mutation	p.E221Q	2
VIM	STAD	chr10	17277380	17277380	G	T	Missense_Mutation	p.E407D	2
VIM	UCEC	chr10	17275610	17275610	C	T	Missense_Mutation	p.R217C	2
VIM	LIHC	chr10	17275658	17275658	T	-	Frame_Shift_Del	p.F233fs	2
VIM	STAD	chr10	17276790	17276790	C	A	Silent	p.T327T	2
VIM	CESC	chr10	17271880	17271880	G	C	Missense_Mutation		2
VIM	UCEC	chr10	17275817	17275817	G	A	Missense_Mutation	p.D257N	2
VIM	ESCA	chr10	17275912	17275912	A	C	Missense_Mutation		2
VIM	LUAD	chr10	17275676	17275676	G	A	Missense_Mutation	p.E239K	2
VIM	BLCA	chr10	17277345	17277345	G	C	Missense_Mutation	p.E396Q	2
VIM	STAD	chr10	17277206	17277206	G	T	Missense_Mutation	p.E349D	2
VIM	CESC	chr10	17278316	17278316	C	T	Silent		2
VIM	UCEC	chr10	17275845	17275845	C	T	Missense_Mutation	p.T266M	2
VIM	BLCA	chr10	17276805	17276805	C	T	Silent	p.A332A	2
VIM	HNSC	chr10	17278348	17278348	G	A	Silent	p.L443L	2
VIM	STAD	chr10	17275857	17275857	G	A	Missense_Mutation	p.R270H	2
VIM	LIHC	chr10	17271663	17271663	A	T	Missense_Mutation	p.Q81L	2
VIM	UCEC	chr10	17278332	17278332	C	G	Nonsense_Mutation	p.S438*	2
VIM	LUAD	chr10	17271973	17271973	C	T	Silent	p.R184R	2
VIM	BLCA	chr10	17271570	17271570	G	A	Missense_Mutation	p.R50H	2
VIM	HNSC	chr10	17275592	17275592	G	C	Missense_Mutation	p.D211H	2
VIM	STAD	chr10	17276730	17276730	C	T	Silent	p.D307D	2
VIM	SKCM	chr10	17271961	17271961	G	A	Silent	p.E180E	2
VIM	LUAD	chr10	17278356	17278356	C	G	Missense_Mutation	p.T446R	2
VIM	BLCA	chr10	17277884	17277884	G	A	Silent	p.L423L	2
VIM	STAD	chr10	17276693	17276693	T	C	Missense_Mutation	p.F295S	2
VIM	SKCM	chr10	17271484	17271484	G	A	Silent	p.A21A	2
VIM	SKCM	chr10	17275604	17275604	C	T	Silent	p.L215L	1
VIM	HNSC	chr10	17275592	17275592	G	C	Missense_Mutation		1
VIM	OV	chr10	17316774	17316774	G	A	Missense_Mutation	p.R320Q	1
VIM	COAD	chr10	17278292	17278292	G	T	Splice_Site	.	1
VIM	LGG	chr10	17277379	17277379	A	T	Missense_Mutation		1
VIM	LIHC	chr10	17277290	17277291	-	C	Frame_Shift_Ins	p.A377fs	1
VIM	LUSC	chr10	17275769	17275769	G	A	Missense_Mutation	p.E241_splice	1
VIM	SKCM	chr10	17275907	17275907	G	A	Missense_Mutation	p.A287T	1
VIM	BLCA	chr10	17277194	17277194	T	C	Silent		1
VIM	HNSC	chr10	17278348	17278348	G	A	Silent		1
VIM	HNSC	chr10	17271591	17271591	C	T	Missense_Mutation	p.P57L	1
VIM	UCEC	chr10	17272668	17272669	-	AG	Frame_Shift_Ins	p.Q195fs	1
VIM	COAD	chr10	17272654	17272654	A	T	Missense_Mutation	p.Q190L	1
VIM	LIHC	chr10	17275861	17275861	C	T	Silent		1
VIM	LUSC	chr10	17271466	17271466	C	A	Missense_Mutation	p.F15L	1
VIM	SKCM	chr10	17271935	17271935	G	A	Missense_Mutation	p.E172K	1
VIM	BLCA	chr10	17275816	17275816	C	T	Silent		1
VIM	HNSC	chr10	17277251	17277251	C	A	Silent		1
VIM	KIRC	chr10	17277297	17277297	C	T	Missense_Mutation	p.L380F	1
VIM	PAAD	chr10	17277377	17277377	C	A	Silent		1
VIM	COAD	chr10	17277213	17277213	G	A	Missense_Mutation	p.A352T	1
VIM	LIHC	chr10	17277885	17277885	A	T	Missense_Mutation	p.R424W	1
VIM	STAD	chr10	17277877	17277877	T	C	Missense_Mutation	p.L421P	1
VIM	BLCA	chr10	17277378	17277378	G	A	Missense_Mutation		1
VIM	HNSC	chr10	17277252	17277252	C	T	Silent		1
VIM	BLCA	chr10	17271444	17271444	C	T	Missense_Mutation	p.S8L	1
VIM	LIHC	chr10	17277290	17277291	-	C	Frame_Shift_Ins	p.S378fs	1
VIM	LUSC	chr10	17277177	17277177	C	A	Missense_Mutation	p.L340M	1
VIM	STAD	chr10	17277192	17277192	C	T	Missense_Mutation	p.R345C	1
VIM	BLCA	chr10	17277291	17277296	CGTCAC	-	In_Frame_Del		1
VIM	HNSC	chr10	17276720	17276720	G	A	Missense_Mutation		1
VIM	BLCA	chr10	17277291	17277296	CGTCAC	-	In_Frame_Del	p.RH378del	1
VIM	ACC	chr10	17275787	17275787	G	C	Missense_Mutation	p.A247P	1
VIM	LIHC	chr10	17271859	17271859	G	-	Frame_Shift_Del	p.L146fs	1
VIM	SKCM	chr10	17277874	17277874	C	T	Missense_Mutation	p.S420F	1
VIM	BLCA	chr10	17275611	17275611	G	A	Missense_Mutation	p.R217H	1
VIM	LUSC	chr10	17275867	17275867	T	A	Silent	p.R273R	1
VIM	STAD	chr10	17271730	17271731	-	A	Frame_Shift_Ins	p.E103fs	1
VIM	KIRP	chr10	17276732	17276732	C	G	Missense_Mutation		1
VIM	LIHC	chr10	17275585	17275585	G	T	Splice_Site		1
VIM	PRAD	chr10	17271519	17271519	C	T	Missense_Mutation	p.T33M	1
VIM	BLCA	chr10	17275611	17275611	G	A	Missense_Mutation		1
VIM	SKCM	chr10	17271885	17271885	G	A	Missense_Mutation	p.R155Q	1
VIM	BLCA	chr10	17275882	17275882	T	A	Missense_Mutation	p.S278R	1
VIM	HNSC	chr10	17276720	17276720	G	A	Missense_Mutation	p.R304Q	1
VIM	LUSC	chr10	17275778	17275778	G	A	Missense_Mutation	p.E244K	1
VIM	THYM	chr10	17271818	17271818	G	T	Missense_Mutation		1
VIM	KIRP	chr10	17278345	17278345	T	G	Silent		1
VIM	LIHC	chr10	17278320	17278320	T	C	Missense_Mutation		1
VIM	SARC	chr10	17271832	17271832	G	T	Missense_Mutation		1
VIM	BLCA	chr10	17275882	17275882	T	A	Missense_Mutation		1
VIM	SKCM	chr10	17271886	17271886	G	A	Silent	p.R155R	1
VIM	HNSC	chr10	17278316	17278316	C	T	Silent	p.L433L	1
VIM	LUSC	chr10	17276803	17276803	G	T	Missense_Mutation	p.A332S	1
VIM	THYM	chr10	17277268	17277268	A	G	Missense_Mutation		1
VIM	LGG	chr10	17276782	17276782	T	C	Missense_Mutation	p.S325P	1
VIM	LIHC	chr10	17271663	17271663	A	T	Missense_Mutation		1
VIM	SARC	chr10	17271932	17271932	G	T	Missense_Mutation	p.V171F	1
VIM	BLCA	chr10	17277345	17277345	G	C	Missense_Mutation		1
VIM	ESCA	chr10	17275817	17275817	G	T	Missense_Mutation	p.D257Y	1
VIM	SKCM	chr10	17277175	17277175	C	T	Missense_Mutation	p.S339F	1
VIM	LUSC	chr10	17278303	17278303	G	T	Silent	p.L428L	1
VIM	THYM	chr10	17277268	17277268	A	G	Missense_Mutation	p.Q370R	1
VIM	CESC	chr10	17271880	17271880	G	C	Missense_Mutation	p.E153D	1
VIM	LGG	chr10	17277273	17277273	A	G	Missense_Mutation	p.M372V	1
VIM	SARC	chr10	17271377	17271377	T	G	RNA	NULL	1
VIM	BLCA	chr10	17276805	17276805	C	T	Silent		1
VIM	GBM	chr10	17271903	17271903	T	G	Missense_Mutation	p.V161G	1
VIM	SKCM	chr10	17271591	17271591	C	G	Missense_Mutation	p.P57R	1
VIM	LUSC	chr10	17278304	17278304	G	T	Missense_Mutation	p.D429Y	1
VIM	CESC	chr10	17278316	17278316	C	T	Silent	p.L433	1
VIM	LGG	chr10	17277379	17277379	A	T	Missense_Mutation	p.E407V	1
VIM	BLCA	chr10	17271570	17271570	G	A	Missense_Mutation		1
VIM	HNSC	chr10	17275622	17275622	G	C	Missense_Mutation		1
VIM	SKCM	chr10	17275649	17275649	G	A	Missense_Mutation	p.E230K	1
VIM	HNSC	chr10	17277252	17277252	C	T	Silent	p.L365L	1
VIM	LUSC	chr10	17271981	17271981	A	G	Missense_Mutation	p.E187G	1
VIM	UCEC	chr10	17277290	17277290	T	C	Silent	p.A377A	1
VIM	COAD	chr10	17272655	17272655	G	A	Silent	p.Q190Q	1
VIM	LGG	chr10	17277273	17277273	A	G	Missense_Mutation		1
VIM	LIHC	chr10	17271486	17271486	G	T	Missense_Mutation	p.S22I	1

Copy number variation (CNV) of VIM
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across VIM
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
98632	KICH	TCGA-KN-8427-01A	AHNAK	chr11	62302488	-	VIM	chr10	17271637	+
98632	N/A	BI495350	ANKRD27	chr19	33109358	-	VIM	chr10	17279589	-
98632	N/A	BI490980	C20orf203	chr20	31229128	-	VIM	chr10	17279592	-
98632	KIRC	TCGA-B4-5838-01A	CCT3	chr1	156307945	-	VIM	chr10	17278293	+
98632	SARC	TCGA-DX-A7EI-01A	COL1A1	chr17	48271491	-	VIM	chr10	17278293	+
98632	SARC	TCGA-DX-A48N-01A	COL3A1	chr2	189872868	+	VIM	chr10	17278293	+
98632	N/A	BG876887	COL5A2	chr2	189897473	-	VIM	chr10	17277284	-
98632	N/A	BI495916	CTD-2307P3.1	chr14	42720561	-	VIM	chr10	17279592	-
98632	Non-Cancer	TCGA-BH-A0DL-11A	DCN	chr12	91545431	-	VIM	chr10	17278293	+
98632	GBM	TCGA-06-0130-01A	DES	chr2	220286282	+	VIM	chr10	17277845	+
98632	STAD	TCGA-HU-A4GQ	DHX9	chr1	182821479	+	VIM	chr10	17278292	+
98632	STAD	TCGA-EQ-8122-01A	EIF4A2	chr3	186505373	+	VIM	chr10	17278293	+
98632	N/A	CV314769	ENO3	chr17	4857622	+	VIM	chr10	17277580	+
98632	N/A	BI495687	FAM155B	chrX	68747865	+	VIM	chr10	17279588	-
98632	N/A	DA713133	GRM7	chr3	7220012	+	VIM	chr10	17271278	+
98632	N/A	BI491863	GUCY1A2	chr11	106612440	-	VIM	chr10	17279592	-
98632	SKCM	TCGA-GN-A26C-01A	HSPG2	chr1	22204679	-	VIM	chr10	17276692	+
98632	N/A	AU120316	JAZF1	chr7	28175197	-	VIM	chr10	17271277	+
98632	N/A	DA914166	KCNT1	chr9	138606305	+	VIM	chr10	17271414	+
98632	GBM	TCGA-27-2524-01A	KRT75	chr12	52822040	-	VIM	chr10	17277845	+
98632	GBM	TCGA-27-1830-01A	KRT77	chr12	53086205	-	VIM	chr10	17277845	+
98632	GBM	TCGA-76-4932-01A	KRT80	chr12	52565982	-	VIM	chr10	17277845	+
98632	N/A	AU120000	LRRC58	chr3	120044613	-	VIM	chr10	17271276	+
98632	HNSC	TCGA-CV-7235	LTF	chr3	46497371	-	VIM	chr10	17272163	+
98632	N/A	BI492657	MMD2	chr7	4956383	+	VIM	chr10	17279591	-
98632	N/A	BI493051	MYH14	chr19	50703688	+	VIM	chr10	17279592	-
98632	N/A	BI496126	NBEA	chr13	35673356	+	VIM	chr10	17279592	-
98632	Non-Cancer	169N	NDRG1	chr8	134256597	-	VIM	chr10	17277844	+
98632	LGG	TCGA-FG-6692-01A	NPM1	chr5	170815010	+	VIM	chr10	17278293	+
98632	N/A	AA483391	PCP4	chr21	41275796	-	VIM	chr10	17279590	-
98632	KIRC	TCGA-BP-4790	PDPR	chr16	70164447	+	VIM	chr10	17276691	+
98632	N/A	BI495283	PET117	chr20	18121460	-	VIM	chr10	17279592	-
98632	N/A	BI492560	PHF20	chr20	34432397	+	VIM	chr10	17279588	-
98632	OV	TCGA-29-1690	PPFIBP1	chr12	27807747	+	VIM	chr10	17277167	+
98632	N/A	CF593924	RASL11B	chr4	53732941	+	VIM	chr10	17271277	+
98632	SKCM	TCGA-EE-A29B-06A	RPS11	chr19	50000812	+	VIM	chr10	17271964	+
98632	SKCM	TCGA-GN-A26C-01A	S100A6	chr1	153508425	-	VIM	chr10	17277168	+
98632	KIRC	TCGA-B8-4143-01A	SLC6A8	chrX	152958975	+	VIM	chr10	17271776	+
98632	N/A	AA368174	TNIP1	chr5	150409573	+	VIM	chr10	17271771	+
98632	SARC	TCGA-DX-AB2T-01A	TNXB	chr6	32016140	-	VIM	chr10	17278293	+
98146	N/A	BI493158	VIM	chr10	17279589	+	AGPAT4	chr6	161606714	-
98146	N/A	AW022242	VIM	chr10	17279592	+	C20orf203	chr20	31229128	+
98146	ACC	TCGA-PK-A5HB-01A	VIM	chr10	17279592	-	CLCN3	chr4	170623929	+
98146	N/A	BI494827	VIM	chr10	17279592	+	CTD-2307P3.1	chr14	42720561	+
100841	N/A	AA569599	VIM	chr10	17279592	+	CTIF	chr18	46112668	-
98146	GBM	TCGA-06-0644-01A	VIM	chr10	17275681	+	DES	chr2	220285217	+
98146	KICH	TCGA-KN-8427-01A	VIM	chr10	17271757	+	DES	chr2	220283497	+
100995	N/A	BI495181	VIM	chr10	17279592	+	DLG2	chr11	83172530	-
100760	KIRC	TCGA-B0-5399-01A	VIM	chr10	17279584	-	DNM1L	chr12	32905677	+
98146	HNSC	TCGA-D6-6826-01A	VIM	chr10	17279592	-	EEA1	chr12	93229203	-
98146	KIRP	TCGA-DZ-6135	VIM	chr10	17270481	+	IGKC	chr2	89160769	-
98146	LUAD	TCGA-75-7025-01A	VIM	chr10	17279592	-	IQCE	chr7	2641075	+
98146	N/A	CV328902	VIM	chr10	17276823	+	IQCG	chr3	197686891	-
98146	N/A	BP225750	VIM	chr10	17279592	+	KIAA1324L	chr7	86510693	-
98146	Non-Cancer	ERR188051	VIM	chr10	17271729	+	KRT81	chr12	52684890	-
98146	Non-Cancer	ERR188295	VIM	chr10	17271726	+	KRT81	chr12	52684893	-
98146	Non-Cancer	ERR188051	VIM	chr10	17271729	+	KRT86	chr12	52696060	+
98146	Non-Cancer	ERR188295	VIM	chr10	17271726	+	KRT86	chr12	52696057	+
98146	SKCM	TCGA-EB-A4IS-01A	VIM	chr10	17279584	-	LAMA4	chr6	112507969	-
98146	SKCM	TCGA-EE-A3AC-06A	VIM	chr10	17271727	+	LMNB1	chr5	126113336	+
98146	N/A	BI496460	VIM	chr10	17279588	+	LRRC4C	chr11	40347602	+
98146	N/A	BG577050	VIM	chr10	17279590	+	ME3	chr11	86345756	-
102124	N/A	AW023960	VIM	chr10	17279592	+	MKL1	chr22	40936778	+
98146	N/A	AW022680	VIM	chr10	17279590	+	MMD2	chr7	4956383	-
98146	N/A	AW022918	VIM	chr10	17279591	+	MMD2	chr7	4956383	-
103043	N/A	AW020904	VIM	chr10	17279592	+	MYH14	chr19	50703688	-
98800	N/A	BF337777	VIM	chr10	17279589	+	PCNT	chr21	47827286	-
98146	N/A	BF338465	VIM	chr10	17279592	+	PDK1	chr2	173450074	-
98146	SKCM	TCGA-D3-A2JO-06A	VIM	chr10	17279592	-	PEX1	chr7	92146729	-
98146	SKCM	TCGA-BF-A1PV-01A	VIM	chr10	17279592	-	PLEKHA5	chr12	19514516	+
98146	UVM	TCGA-VD-A8K9-01A	VIM	chr10	17279592	-	PLEKHA5	chr12	19441012	+
98146	BLCA	TCGA-K4-A5RH-01A	VIM	chr10	17279592	-	PTPRC	chr1	198710998	+
98146	N/A	BI858459	VIM	chr10	17279592	+	RALGAPA1	chr14	36166871	-
98146	N/A	BI495611	VIM	chr10	17279593	+	RHD	chr1	25603020	+
98146	Non-Cancer	TCGA-55-6986-11A	VIM	chr10	17279576	+	RPPH1	chr14	20811232	-
98146	Non-Cancer	TCGA-BH-A1EO-11A	VIM	chr10	17279578	+	RPPH1	chr14	20811230	-
98146	N/A	BI862420	VIM	chr10	17279590	+	SEC63	chr6	108242637	+
100710	N/A	BF569677	VIM	chr10	17271344	+	SERINC3	chr20	43126992	-
98146	SKCM	TCGA-EE-A2MF-06A	VIM	chr10	17279592	-	SGK3	chr8	67716610	+
98682	KIRC	TCGA-A3-3317-01A	VIM	chr10	17279584	-	SIAE	chr11	124543777	-
98146	STAD	TCGA-BR-8682-01A	VIM	chr10	17279584	-	STAT6	chr12	57496773	-
98146	N/A	BM015096	VIM	chr10	17279589	+	SYT14	chr1	210204641	-
98146	N/A	BI856354	VIM	chr10	17279590	+	TIAM2	chr6	155350932	-
98632	N/A	BG928012	VIM	chr10	17275787	+	VIM	chr10	17271730	+
98632	N/A	BI496459	VWA8	chr13	42470002	+	VIM	chr10	17279591	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUAD	VIM	0.00261002457713704	0.073
SARC	VIM	0.0037612048180675	0.1
TGCT	VIM	0.00470441250386507	0.12
THCA	VIM	0.00846632262123055	0.21
KIRC	VIM	0.0110882323444335	0.27
PAAD	VIM	0.0440696711745537	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	VIM	0.0448996638121935	1
THCA	VIM	0.0120826988133019	0.39
BRCA	VIM	0.0133898176707137	0.42
THYM	VIM	0.0273967265825723	0.82
SARC	VIM	0.00786742382460871	0.26

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
P08670	DB12695	Phenethyl Isothiocyanate		Small molecule	Investigational
P08670	DB12695	Phenethyl Isothiocyanate

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0006142	Malignant neoplasm of breast	4	CTD_human
C0678222	Breast Carcinoma	4	CTD_human
C1257931	Mammary Neoplasms, Human	4	CTD_human
C3805411	CATARACT 30	4	GENOMICS_ENGLAND;UNIPROT
C4704874	Mammary Carcinoma, Human	4	CTD_human
C0023890	Liver Cirrhosis	2	CTD_human
C0029408	Degenerative polyarthritis	2	CTD_human
C0086743	Osteoarthrosis Deformans	2	CTD_human
C0239946	Fibrosis, Liver	2	CTD_human
C0376358	Malignant neoplasm of prostate	2	CTD_human
C0007140	Carcinosarcoma	1	CTD_human
C0019193	Hepatitis, Toxic	1	CTD_human
C0023893	Liver Cirrhosis, Experimental	1	CTD_human
C0027720	Nephrosis	1	CTD_human
C0035126	Reperfusion Injury	1	CTD_human
C0039101	synovial sarcoma	1	CTD_human
C0085084	Motor Neuron Disease	1	CTD_human
C0086543	Cataract	1	CTD_human
C0154681	Anterior Horn Cell Disease	1	CTD_human
C0154682	Lateral Sclerosis	1	CTD_human
C0270763	Familial Motor Neuron Disease	1	CTD_human
C0270764	Motor Neuron Disease, Lower	1	CTD_human
C0345967	Malignant mesothelioma	1	CTD_human
C0346990	Carcinomatosis of peritoneal cavity	1	CTD_human
C0521659	Motor Neuron Disease, Upper	1	CTD_human
C0524524	Pseudoaphakia	1	CTD_human
C0543858	Motor Neuron Disease, Secondary	1	CTD_human
C0948089	Acute Coronary Syndrome	1	CTD_human
C1262760	Hepatitis, Drug-Induced	1	CTD_human
C1833118	Cataract, Pulverulent	1	ORPHANET
C1852438	CATARACT, COPPOCK-LIKE	1	ORPHANET
C1862939	AMYOTROPHIC LATERAL SCLEROSIS 1	1	CTD_human
C1862941	Amyotrophic Lateral Sclerosis, Sporadic	1	CTD_human
C3658290	Drug-Induced Acute Liver Injury	1	CTD_human
C4277682	Chemical and Drug Induced Liver Injury	1	CTD_human
C4279912	Chemically-Induced Liver Toxicity	1	CTD_human
C4551993	Amyotrophic Lateral Sclerosis, Familial	1	CTD_human