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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: FTO (NCBI Gene ID:79068)

Gene Summary

Gene Summary

Gene Information	Gene Name: FTO
	Gene ID: 79068
	Gene Symbol	FTO
	Gene ID	79068
	Gene Name	FTO alpha-ketoglutarate dependent dioxygenase
	Synonyms	ALKBH9\|BMIQ14\|GDFD
	Cytomap	16q12.2
	Type of Gene	protein-coding
	Description	alpha-ketoglutarate-dependent dioxygenase FTOAlkB homolog 9U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTOU6 small nuclear RNA N(6)-methyladenosine-demethylase FTOfat mass and obesity associatedfat mass and obesity-associated protei
	Modification date	20200329
	UniProtAcc	Q9C0B1

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	FTO	GO:0006307	DNA dealkylation involved in DNA repair	18775698\|20376003
Hgene	FTO	GO:0035552	oxidative single-stranded DNA demethylation	18775698\|20376003
Hgene	FTO	GO:0035553	oxidative single-stranded RNA demethylation	18775698\|22002720\|25452335\|26457839\|28002401\|30197295
Hgene	FTO	GO:0042245	RNA repair	18775698
Hgene	FTO	GO:0061157	mRNA destabilization	28002401\|30197295
Hgene	FTO	GO:0070989	oxidative demethylation	18775698
Hgene	FTO	GO:0080111	DNA demethylation	18775698

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
FTO	(355.7 - 733]

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Translation Studies in PubMed

We searched PubMed using 'FTO[title] AND translation [title] AND human.'

Gene	Title	PMID
FTO	Loss of FTO in adipose tissue decreases Angptl4 translation and alters triglyceride metabolism	26671148

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000471389	53859775	53860403	Frame-shift
ENST00000471389	53878066	53878210	In-frame
ENST00000471389	53907697	53907777	Frame-shift
ENST00000471389	53913755	53913899	In-frame
ENST00000471389	53967896	53968021	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000471389	53878066	53878210	11783	974	1117	505	250	298
ENST00000471389	53913755	53913899	11783	1198	1341	505	325	373

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q9C0B1	325	373	1	505	Chain	ID=PRO_0000286163;Note=Alpha-ketoglutarate-dependent dioxygenase FTO
Q9C0B1	250	298	1	505	Chain	ID=PRO_0000286163;Note=Alpha-ketoglutarate-dependent dioxygenase FTO
Q9C0B1	325	373	32	327	Region	Note=Fe2OG dioxygenase domain
Q9C0B1	250	298	32	327	Region	Note=Fe2OG dioxygenase domain
Q9C0B1	250	298	295	295	Binding site	Note=Alpha-ketoglutarate
Q9C0B1	325	373	1	445	Alternative sequence	ID=VSP_025002;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9C0B1	250	298	1	445	Alternative sequence	ID=VSP_025002;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9C0B1	325	373	1	399	Alternative sequence	ID=VSP_025003;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9C0B1	250	298	1	399	Alternative sequence	ID=VSP_025003;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9C0B1	325	373	1	378	Alternative sequence	ID=VSP_025004;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9C0B1	250	298	1	378	Alternative sequence	ID=VSP_025004;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9C0B1	250	298	271	271	Natural variant	ID=VAR_076423;Note=Found in a patient with microcephaly%2C developmental delay%2C behavioral abnormalities%2C dysmorphic facial features%2C hypotonia and other various phenotypic abnormalities%3B unknown pathological significance. H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:26740239;Dbxref=PMID:26740239
Q9C0B1	250	298	271	276	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4IE5
Q9C0B1	250	298	280	282	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4IE5
Q9C0B1	250	298	284	288	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4IE5
Q9C0B1	250	298	293	297	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4IE5
Q9C0B1	325	373	327	330	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5F8P
Q9C0B1	325	373	331	342	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4IE5
Q9C0B1	325	373	361	377	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4IE5

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
BRCA	FTO	-2.09494010696594	3.14552302519821e-23
KIRC	FTO	1.08234124384934	4.81926317698848e-12

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
OV	FTO	hsa-miR-150-5p	98	0.317168957568514	0.0223703409674884

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
BRCA	FTO	-0.095086881	0.002104426
SARC	FTO	0.331392566	0.006071834
TGCT	FTO	0.086583474	0.034214297

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with FTO (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	FTO	MTR	0.814679394	1.85E-12
DLBC	Cell metabolism gene	FTO	LONP2	0.826860549	4.46E-13
DLBC	Cell metabolism gene	FTO	PDPR	0.83405724	1.82E-13
DLBC	Cell metabolism gene	FTO	EP300	0.836745746	1.29E-13
DLBC	CGC	FTO	KDM5A	0.803554629	6.22E-12
DLBC	CGC	FTO	AFF4	0.803605815	6.19E-12
DLBC	CGC	FTO	BIRC6	0.80395403	5.96E-12
DLBC	CGC	FTO	EP300	0.836745746	1.29E-13
DLBC	Epifactor	FTO	KDM5A	0.803554629	6.22E-12
DLBC	Epifactor	FTO	EP300	0.836745746	1.29E-13
DLBC	IUPHAR	FTO	KDM5A	0.803554629	6.22E-12
DLBC	IUPHAR	FTO	BIRC6	0.80395403	5.96E-12
DLBC	IUPHAR	FTO	MTR	0.814679394	1.85E-12
DLBC	IUPHAR	FTO	CLCN3	0.824060339	6.24E-13
DLBC	IUPHAR	FTO	EP300	0.836745746	1.29E-13
DLBC	TF	FTO	ATF7	0.819270189	1.10E-12
DLBC	TF	FTO	AHCTF1	0.830600003	2.82E-13
DLBC	TF	FTO	ZNF827	0.844716284	4.47E-14
DLBC	TSG	FTO	KDM5A	0.803554629	6.22E-12
DLBC	TSG	FTO	PHLPP2	0.813976137	2.00E-12
LAML	IUPHAR	FTO	NEK10	0.863908652	8.15E-53
LAML	Kinase	FTO	NEK10	0.863908652	8.15E-53
TGCT	Cell metabolism gene	FTO	PHKB	0.809828451	1.70E-37
THYM	Cell metabolism gene	FTO	YAP1	0.801572216	1.42E-28
THYM	Cell metabolism gene	FTO	GXYLT1	0.807040268	3.15E-29
THYM	Cell metabolism gene	FTO	PIGK	0.807154548	3.05E-29
THYM	Cell metabolism gene	FTO	FBXL3	0.814371175	3.90E-30
THYM	Cell metabolism gene	FTO	MCFD2	0.854035024	7.42E-36
THYM	CGC	FTO	PPFIBP1	0.822685008	3.25E-31
THYM	CGC	FTO	ABL1	0.842343118	5.24E-34
THYM	Epifactor	FTO	SMARCA1	0.811391077	9.22E-30
THYM	IUPHAR	FTO	MYLK4	0.810907855	1.06E-29
THYM	IUPHAR	FTO	SLC35A5	0.832676822	1.37E-32
THYM	IUPHAR	FTO	SGK3	0.838153157	2.22E-33
THYM	IUPHAR	FTO	ABL1	0.842343118	5.24E-34
THYM	IUPHAR	FTO	MBTPS1	0.887984233	2.68E-42
THYM	Kinase	FTO	MYLK4	0.810907855	1.06E-29
THYM	Kinase	FTO	SGK3	0.838153157	2.22E-33
THYM	Kinase	FTO	ABL1	0.842343118	5.24E-34
THYM	TF	FTO	ZNF614	0.800449345	1.92E-28
THYM	TF	FTO	ZNF471	0.801071768	1.62E-28
THYM	TF	FTO	ZNF91	0.803352607	8.72E-29
THYM	TF	FTO	ZNF772	0.805338107	5.06E-29
THYM	TF	FTO	ZNF470	0.809507345	1.58E-29
THYM	TF	FTO	ZNF154	0.813610174	4.87E-30
THYM	TF	FTO	ZNF441	0.824514905	1.85E-31
THYM	TF	FTO	ZNF780B	0.824723546	1.73E-31
THYM	TF	FTO	ZNF319	0.851086482	2.25E-35
THYM	TF	FTO	NFAT5	0.887677868	3.13E-42
THYM	TSG	FTO	SERPINB5	0.800056426	2.13E-28
THYM	TSG	FTO	YAP1	0.801572216	1.42E-28
THYM	TSG	FTO	RECK	0.821104163	5.27E-31
THYM	TSG	FTO	ARHGAP29	0.836100201	4.43E-33
THYM	TSG	FTO	KANK1	0.842164095	5.58E-34
THYM	TSG	FTO	DNAJB4	0.843506847	3.49E-34
THYM	TSG	FTO	NEDD4	0.8791331	1.96E-40
THYM	TSG	FTO	RASSF8	0.879733385	1.48E-40
UCS	Cell metabolism gene	FTO	YAP1	0.801572216	1.42E-28
UCS	Cell metabolism gene	FTO	GXYLT1	0.807040268	3.15E-29
UCS	Cell metabolism gene	FTO	PIGK	0.807154548	3.05E-29
UCS	Cell metabolism gene	FTO	FBXL3	0.814371175	3.90E-30
UCS	Cell metabolism gene	FTO	MCFD2	0.854035024	7.42E-36
UCS	CGC	FTO	PPFIBP1	0.822685008	3.25E-31
UCS	CGC	FTO	ABL1	0.842343118	5.24E-34
UCS	Epifactor	FTO	SMARCA1	0.811391077	9.22E-30
UCS	IUPHAR	FTO	MYLK4	0.810907855	1.06E-29
UCS	IUPHAR	FTO	SLC35A5	0.832676822	1.37E-32
UCS	IUPHAR	FTO	SGK3	0.838153157	2.22E-33
UCS	IUPHAR	FTO	ABL1	0.842343118	5.24E-34
UCS	IUPHAR	FTO	MBTPS1	0.887984233	2.68E-42
UCS	Kinase	FTO	MYLK4	0.810907855	1.06E-29
UCS	Kinase	FTO	SGK3	0.838153157	2.22E-33
UCS	Kinase	FTO	ABL1	0.842343118	5.24E-34
UCS	TF	FTO	ZNF614	0.800449345	1.92E-28
UCS	TF	FTO	ZNF471	0.801071768	1.62E-28
UCS	TF	FTO	ZNF91	0.803352607	8.72E-29
UCS	TF	FTO	ZNF772	0.805338107	5.06E-29
UCS	TF	FTO	ZNF470	0.809507345	1.58E-29
UCS	TF	FTO	ZNF154	0.813610174	4.87E-30
UCS	TF	FTO	ZNF441	0.824514905	1.85E-31
UCS	TF	FTO	ZNF780B	0.824723546	1.73E-31
UCS	TF	FTO	ZNF319	0.851086482	2.25E-35
UCS	TF	FTO	NFAT5	0.887677868	3.13E-42
UCS	TSG	FTO	SERPINB5	0.800056426	2.13E-28
UCS	TSG	FTO	YAP1	0.801572216	1.42E-28
UCS	TSG	FTO	RECK	0.821104163	5.27E-31
UCS	TSG	FTO	ARHGAP29	0.836100201	4.43E-33
UCS	TSG	FTO	KANK1	0.842164095	5.58E-34
UCS	TSG	FTO	DNAJB4	0.843506847	3.49E-34
UCS	TSG	FTO	NEDD4	0.8791331	1.96E-40
UCS	TSG	FTO	RASSF8	0.879733385	1.48E-40

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
COAD	FTO	ALKBH5	2.13755552147488	0.000465095043182374
LUAD	FTO	YTHDF2	1.21267726315751	0.00092062023200824
LUAD	FTO	METTL14	-1.43596594596523	0.00121089428940613
STAD	FTO	YTHDF2	-4.95694120741537	0.00361521635204554
HNSC	FTO	ALKBH1	-2.39538842109683	0.00633394569399571
LUAD	FTO	WTAP	-1.78616226090853	0.00791615044666943
KIRC	FTO	WTAP	-2.70273660495067	0.0143053039058135
UCEC	FTO	TMEM18	-1.3828461536382	0.015625
BLCA	FTO	WTAP	-2.90881954846739	0.0159721374511719
READ	FTO	ALKBH5	2.44404366714817	0.03125
CHOL	FTO	METTL3	-3.31943495691848	0.0390625
UCEC	FTO	WTAP	-3.78629147221377	0.046875
THCA	FTO	ALKBH5	-1.26370742071388	1.35265985423686e-05
COAD	FTO	METTL3	-3.54288918740857	2.08616256713867e-06
THCA	FTO	METTL14	-2.3091931665824	3.03433720687169e-07
KIRP	FTO	YTHDF1	-1.2717266330147	3.17529775202275e-05
LIHC	FTO	METTL3	-1.43381447667708	3.17814170396599e-08
PRAD	FTO	METTL3	2.27777667743557	5.10126106041513e-07
THCA	FTO	WTAP	-2.89392443867004	5.83719995580266e-05
KIRC	FTO	ALKBH5	1.22008443269992	8.228320553924e-07
KICH	FTO	YTHDF1	-1.28076147925582	8.80360603332519e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with FTO

BCCIP, CKB, CNDP2, DAK, EEF2, PEPD, CTSA, LDHA, LDHB, MVD, NDRG1, NPEPPS, SLC9A3R1, ZMAT3, SBF2, GPX7, MPZL1, ZNF232, FSD1, FGB, NFYA, OR5F1, ALX3, DIRAS2, TYW3, SDC1, RECQL4, CLUAP1, TTC19, PRDM6, DTX2, TNPO2, MAD2L2, C1orf109, GNG13, USP20, MORN3, SHC3, NXF1, ANKRD11, IL16, CLP1, EFEMP2, ZNF77, KLHL38, CCDC57, GPANK1, PRNP, DDX58, OGT, TULP3, HIST1H2BG, SPANXN4, HOXC5, MTPN, GNG2, CARTPT, GNG8, C19orf25, CDKN2AIP, SPANXN5, OSGEP, MAGEF1, PGAP2, CRCP, ENTPD7, ALS2CR12, RIPK4, NAT1, SPRED2, RNF144A, SLC2A5, AMD1, IQGAP1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
FTO	chr16	53737887	A	T	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FTO	chr16	53737911	C	G	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FTO	chr16	53737929	C	G	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FTO	chr16	53737957	T	C	single_nucleotide_variant	Likely_benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FTO	chr16	53737960	G	C	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FTO	chr16	53737975	C	G	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FTO	chr16	53738054	G	A	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FTO	chr16	53738091	G	A	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FTO	chr16	53738092	GC	G	Deletion	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FTO	chr16	53738108	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant
FTO	chr16	53738149	G	T	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FTO	chr16	53800954	T	C	single_nucleotide_variant	risk_factor	OBESITY_(BMIQ14),_SUSCEPTIBILITY_TO	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FTO	chr16	53844105	C	T	single_nucleotide_variant	Benign/Likely_benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death\|not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
FTO	chr16	53844134	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FTO	chr16	53859794	A	C	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant
FTO	chr16	53859806	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001587\|nonsense,SO:0001623\|5_prime_UTR_variant	SO:0001587\|nonsense,SO:0001623\|5_prime_UTR_variant
FTO	chr16	53859826	T	C	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant	SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant
FTO	chr16	53859890	C	T	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant
FTO	chr16	53859915	A	G	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant
FTO	chr16	53859930	C	G	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant
FTO	chr16	53860052	G	A	single_nucleotide_variant	Benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death\|not_provided	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant
FTO	chr16	53860080	A	G	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant
FTO	chr16	53860082	G	A	single_nucleotide_variant	Likely_benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant
FTO	chr16	53860139	G	A	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death\|not_provided	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant
FTO	chr16	53860197	G	C	single_nucleotide_variant	Benign/Likely_benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
FTO	chr16	53860252	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
FTO	chr16	53860253	G	A	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001583\|missense_variant	SO:0001583\|missense_variant
FTO	chr16	53860348	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
FTO	chr16	53860373	G	A	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001583\|missense_variant	SO:0001583\|missense_variant
FTO	chr16	53860406	A	G	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
FTO	chr16	53878069	C	T	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant
FTO	chr16	53878082	G	A	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death\|not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant
FTO	chr16	53878098	T	A	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant
FTO	chr16	53878172	C	T	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death\|not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant
FTO	chr16	53907714	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
FTO	chr16	53907749	G	A	single_nucleotide_variant	Pathogenic	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001583\|missense_variant	SO:0001583\|missense_variant
FTO	chr16	53907755	GT	G	Deletion	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
FTO	chr16	53907758	C	T	single_nucleotide_variant	Pathogenic	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001583\|missense_variant	SO:0001583\|missense_variant
FTO	chr16	53907761	C	T	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001583\|missense_variant	SO:0001583\|missense_variant
FTO	chr16	53907776	A	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
FTO	chr16	53913782	T	C	single_nucleotide_variant	Benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death\|not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
FTO	chr16	53913853	C	T	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
FTO	chr16	53913906	ACTTT	A	Microsatellite	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FTO	chr16	53913911	C	CT	Duplication	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FTO	chr16	53922746	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
FTO	chr16	53922803	T	G	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
FTO	chr16	53922822	A	G	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001583\|missense_variant	SO:0001583\|missense_variant
FTO	chr16	53922838	C	T	single_nucleotide_variant	Benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
FTO	chr16	53967893	G	A	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FTO	chr16	53967931	G	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant
FTO	chr16	53967939	G	A	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant
FTO	chr16	53967952	A	G	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant
FTO	chr16	53967963	A	C	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant
FTO	chr16	54145674	G	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54145693	C	T	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001583\|missense_variant,SO:0001587\|nonsense,SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001587\|nonsense,SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54145786	G	T	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54145866	G	A	single_nucleotide_variant	Likely_benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54145915	C	A	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54145928	C	A	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54145943	C	T	single_nucleotide_variant	Benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54145952	A	G	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54146022	A	T	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54146108	G	A	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54146125	C	T	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54146128	G	A	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54146149	T	C	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54146188	C	A	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54146221	A	T	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54146336	G	A	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54146395	C	T	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54146424	G	A	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54146446	A	C	single_nucleotide_variant	Benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54146485	A	G	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54146548	T	G	single_nucleotide_variant	Benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54146616	C	T	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54146715	G	A	single_nucleotide_variant	Likely_benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54146758	C	A	single_nucleotide_variant	Benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54146884	G	C	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54146888	C	T	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54146898	G	C	single_nucleotide_variant	Benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54146909	G	A	single_nucleotide_variant	Benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54146997	A	T	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54147022	T	C	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54147042	G	T	single_nucleotide_variant	Likely_benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54147107	C	T	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54147108	G	A	single_nucleotide_variant	Likely_benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54147142	C	T	single_nucleotide_variant	Benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54147158	G	A	single_nucleotide_variant	Benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54147200	GC	G	Deletion	Likely_benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54147205	C	A	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54147205	C	G	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54147206	C	T	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54147206	CG	C	Deletion	Benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54147207	G	T	single_nucleotide_variant	Benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54147230	C	T	single_nucleotide_variant	Benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54147377	C	A	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54147419	G	A	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54147531	T	C	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54147551	A	G	single_nucleotide_variant	Likely_benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54147572	G	A	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54147591	CG	C	Deletion	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54147656	G	A	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54147687	A	C	single_nucleotide_variant	Benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54147722	TC	T	Deletion	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54147723	C	CT	Duplication	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54147723	CT	C	Deletion	Benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54147771	G	T	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54147829	C	T	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54147866	C	T	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54147885	A	G	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54147907	A	T	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54147935	G	A	single_nucleotide_variant	Benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54148007	C	T	single_nucleotide_variant	Benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54148017	A	G	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54148019	G	T	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54148037	A	G	single_nucleotide_variant	Benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54148076	A	T	single_nucleotide_variant	Benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54148118	G	A	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54148128	G	A	single_nucleotide_variant	Benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54148160	C	T	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54148161	G	A	single_nucleotide_variant	Benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54148189	G	T	single_nucleotide_variant	Benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54148193	C	G	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54148228	C	T	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54148239	C	G	single_nucleotide_variant	Uncertain_significance	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54148269	A	T	single_nucleotide_variant	Benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
FTO	chr16	54148378	G	A	single_nucleotide_variant	Benign	Growth_retardation,_developmental_delay,_coarse_facies,_and_early_death	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
FTO	ACC	chr16	53860242	53860242	C	T	Missense_Mutation	p.A197V	3
FTO	ESCA	chr16	53860093	53860093	G	T	Missense_Mutation	p.Q147H	3
FTO	PRAD	chr16	53913791	53913791	C	T	Silent	p.R337R	3
FTO	LIHC	chr16	53878098	53878098	T	A	Missense_Mutation		3
FTO	ESCA	chr16	53967949	53967949	G	C	Missense_Mutation	p.R431T	3
FTO	LIHC	chr16	53878098	53878098	T	A	Missense_Mutation	p.H261Q	3
FTO	COAD	chr16	53860211	53860211	G	A	Missense_Mutation	p.G187R	3
FTO	BLCA	chr16	53913760	53913760	C	G	Nonsense_Mutation	p.S327*	3
FTO	PCPG	chr16	53859931	53859931	G	A	Silent		2
FTO	STAD	chr16	54145683	54145683	A	G	Silent	p.S458S	2
FTO	LUAD	chr16	53967990	53967990	C	T	Missense_Mutation	p.R445C	2
FTO	UCEC	chr16	53913822	53913822	G	A	Missense_Mutation	p.D348N	2
FTO	PCPG	chr16	53859931	53859931	G	A	Silent	p.P93P	2
FTO	UCEC	chr16	53922747	53922747	G	A	Missense_Mutation	p.E375K	2
FTO	UCEC	chr16	53922795	53922795	A	C	Missense_Mutation	p.K391Q	2
FTO	UCEC	chr16	54145754	54145754	C	T	Missense_Mutation	p.S482L	2
FTO	ESCA	chr16	53860093	53860093	G	T	Missense_Mutation		2
FTO	LUAD	chr16	53859963	53859963	G	T	Missense_Mutation	p.C104F	2
FTO	UCEC	chr16	54145785	54145785	C	T	Silent	p.I492	2
FTO	LUAD	chr16	53878094	53878094	C	G	Missense_Mutation	p.S260C	2
FTO	LIHC	chr16	53844101	53844101	C	-	Frame_Shift_Del	p.T32fs	2
FTO	ESCA	chr16	53967949	53967949	G	C	Missense_Mutation		2
FTO	BLCA	chr16	53878094	53878094	C	T	Missense_Mutation	p.S260F	2
FTO	BLCA	chr16	53967950	53967950	G	A	Silent	p.R431R	2
FTO	UCEC	chr16	53738099	53738120	GAAGCGCACCCCGACTGCCGAG	-	Frame_Shift_Del	p.K2fs	2
FTO	ESCA	chr16	53860211	53860211	G	T	Nonsense_Mutation	p.G187X	2
FTO	KIRC	chr16	53878083	53878083	T	G	Missense_Mutation	p.S256R	2
FTO	BLCA	chr16	53967927	53967927	G	C	Missense_Mutation	p.E424Q	2
FTO	UCEC	chr16	53844129	53844129	G	T	Missense_Mutation	p.Q41H	2
FTO	STAD	chr16	53859941	53859941	A	G	Missense_Mutation	p.I97V	2
FTO	UCEC	chr16	53859803	53859803	C	A	Missense_Mutation	p.L51I	2
FTO	HNSC	chr16	53967915	53967915	G	A	Missense_Mutation		1
FTO	BLCA	chr16	53860020	53860020	C	T	Missense_Mutation	p.S123F	1
FTO	LGG	chr16	53922781	53922781	G	A	Missense_Mutation	p.G386D	1
FTO	DLBC	chr16	53922838	53922838	C	T	Missense_Mutation	p.A405V	1
FTO	BLCA	chr16	53878094	53878094	C	T	Missense_Mutation		1
FTO	HNSC	chr16	53859936	53859936	C	T	Missense_Mutation		1
FTO	CESC	chr16	53922804	53922804	G	A	Missense_Mutation		1
FTO	LIHC	chr16	53859999	53859999	T	C	Missense_Mutation		1
FTO	STAD	chr16	53967976	53967976	C	T	Missense_Mutation	p.A440V	1
FTO	LUAD	chr16	53907721	53907721	C	T	Missense_Mutation	p.H307Y	1
FTO	BLCA	chr16	53967927	53967927	G	C	Missense_Mutation		1
FTO	HNSC	chr16	53907751	53907751	T	A	Missense_Mutation		1
FTO	COAD	chr16	53844116	53844116	A	C	Missense_Mutation	p.E37A	1
FTO	STAD	chr16	54145700	54145700	T	A	Nonsense_Mutation	p.L464*	1
FTO	LUAD	chr16	53878065	53878065	A	G	Splice_Site		1
FTO	READ	chr16	53860037	53860037	G	A	Missense_Mutation	p.E129K	1
FTO	BLCA	chr16	54145865	54145865	C	T	Missense_Mutation		1
FTO	HNSC	chr16	53922747	53922747	G	C	Missense_Mutation		1
FTO	COAD	chr16	53859806	53859806	C	T	Nonsense_Mutation	p.R52X	1
FTO	THCA	chr16	53907736	53907736	G	A	Missense_Mutation		1
FTO	ESCA	chr16	53860211	53860211	G	T	Nonsense_Mutation	p.G187*	1
FTO	LUAD	chr16	53860355	53860355	A	T	Missense_Mutation	p.N235Y	1
FTO	SARC	chr16	53878067	53878067	G	T	Missense_Mutation		1
FTO	BLCA	chr16	53922746	53922746	C	A	Silent		1
FTO	HNSC	chr16	53922747	53922747	G	C	Missense_Mutation	p.E375Q	1
FTO	COAD	chr16	53859930	53859930	C	T	Missense_Mutation	p.P93L	1
FTO	LIHC	chr16	53878176	53878177	-	C	Frame_Shift_Ins	p.IP287fs	1
FTO	THCA	chr16	53968001	53968001	G	A	Silent		1
FTO	LUSC	chr16	53844090	53844090	C	T	Silent	p.L28L	1
FTO	SARC	chr16	53945311	53945311	G	T	Missense_Mutation		1
FTO	BLCA	chr16	54145873	54145873	C	T	Silent		1
FTO	HNSC	chr16	53907751	53907751	T	A	Missense_Mutation	p.F317I	1
FTO	LIHC	chr16	53844106	53844106	A	-	Frame_Shift_Del	p.K34fs	1
FTO	THCA	chr16	53968001	53968001	G	A	Silent	p.L448L	1
FTO	ESCA	chr16	53967939	53967939	G	T	Missense_Mutation		1
FTO	LUSC	chr16	53913764	53913764	A	G	Silent	p.T328T	1
FTO	SKCM	chr16	53913891	53913891	C	T	Missense_Mutation	p.H371Y	1
FTO	BLCA	chr16	53860020	53860020	C	T	Missense_Mutation		1
FTO	HNSC	chr16	53859936	53859936	C	T	Missense_Mutation	p.S95F	1
FTO	COAD	chr16	53860277	53860277	C	A	Missense_Mutation	p.P209T	1
FTO	UCEC	chr16	53913867	53913867	G	T	Missense_Mutation	p.V363F	1
FTO	LUSC	chr16	53922817	53922817	A	T	Missense_Mutation	p.Q398L	1
FTO	LUSC	chr16	53878072	53878072	G	C	Missense_Mutation	p.E253Q	1
FTO	SKCM	chr16	53859927	53859927	C	T	Missense_Mutation	p.T92I	1
FTO	HNSC	chr16	53967915	53967915	G	A	Missense_Mutation	p.E420K	1
FTO	COAD	chr16	53907766	53907766	C	T	Nonsense_Mutation	p.R322X	1
FTO	LIHC	chr16	53738107	53738107	C	-	Frame_Shift_Del	p.T4fs	1
FTO	UCEC	chr16	53738099	53738120	GAAGCGCACCCCGACTGCCGAG	-	Frame_Shift_Del	p.M1fs	1
FTO	ESCA	chr16	53967939	53967939	G	T	Missense_Mutation	p.V428L	1
FTO	LUSC	chr16	53907755	53907755	G	T	Missense_Mutation	p.S318I	1
FTO	OV	chr16	52417440	52417440	G	T	Missense_Mutation	p.R96L	1
FTO	SKCM	chr16	53860322	53860322	G	A	Missense_Mutation	p.G224R	1
FTO	HNSC	chr16	53844097	53844097	C	G	Missense_Mutation	p.L31V	1
FTO	COAD	chr16	54145700	54145700	T	C	Missense_Mutation	p.L464S	1
FTO	LIHC	chr16	53859992	53859992	T	-	Frame_Shift_Del	p.F114fs	1
FTO	PAAD	chr16	54145726	54145726	C	T	Missense_Mutation		1
FTO	STAD	chr16	54145700	54145700	T	A	Nonsense_Mutation	p.L464X	1
FTO	COAD	chr16	53878111	53878111	G	A	Missense_Mutation	p.D266N	1
FTO	LIHC	chr16	53913873	53913873	A	-	Frame_Shift_Del	p.K365fs	1
FTO	HNSC	chr16	53844097	53844097	C	G	Missense_Mutation		1
FTO	PAAD	chr16	54145726	54145726	C	T	Missense_Mutation	p.R473W	1
FTO	KIRC	chr16	53922839	53922839	A	G	Silent	p.A405A	1
FTO	DLBC	chr16	53860253	53860253	G	A	Missense_Mutation	p.V201I	1
FTO	LIHC	chr16	54145677	54145677	C	-	Frame_Shift_Del	p.C456fs	1

Copy number variation (CNV) of FTO
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across FTO
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
96672	BRCA	TCGA-E2-A150	ACTN4	chr19	39138547	+	FTO	chr16	53844051	+
96672	BRCA	TCGA-E2-A150-01A	ACTN4	chr19	39138546	+	FTO	chr16	53844051	+
96672	BRCA	TCGA-E2-A150-01A	ACTN4	chr19	39138547	+	FTO	chr16	53844052	+
96672	SARC	TCGA-WP-A9GB-01A	AMFR	chr16	56401356	-	FTO	chr16	53967897	+
96672	N/A	AV695341	APOC4-APOC2	chr19	45452652	+	FTO	chr16	53812793	-
96672	STAD	TCGA-CD-8534	ATP2C2	chr16	84432215	+	FTO	chr16	53967896	+
96672	STAD	TCGA-CD-8534-01A	ATP2C2	chr16	84432215	+	FTO	chr16	53967897	+
96672	BRCA	TCGA-S3-AA12	CABLES1	chr18	20716571	+	FTO	chr16	54145673	+
96672	BRCA	TCGA-S3-AA12-01A	CABLES1	chr18	20716570	+	FTO	chr16	54145673	+
96672	BRCA	TCGA-S3-AA12-01A	CABLES1	chr18	20716571	+	FTO	chr16	54145674	+
96672	N/A	BF246210	COMMD6	chr13	76100572	-	FTO	chr16	53984040	+
96672	N/A	AY515894	CTC-535M15.2	chr5	165198771	-	FTO	chr16	53780309	+
90965	LUAD	TCGA-95-8039-01A	FTO	chr16	53738141	+	RBL2	chr16	53472928	+
96065	N/A	BI495307	FTO	chr16	54120014	+	RNF13	chr3	149679915	-
78026	BLCA	TCGA-GC-A3YS-01A	FTO	chr16	53738141	+	TMEM231	chr16	75589871	-
102055	ESCA	TCGA-JY-A6FE-01A	FTO	chr16	53738141	+	ZNF423	chr16	49559405	-
102316	HNSC	TCGA-CN-5364-01A	FTO	chr16	53738141	-	ZNF536	chr19	31025754	+
96672	SARC	TCGA-WP-A9GB-01A	GNAO1	chr16	56226528	+	FTO	chr16	53967897	+
96672	ESCA	TCGA-2H-A9GH	NLRC5	chr16	57079404	+	FTO	chr16	54145673	+
96672	ESCA	TCGA-2H-A9GH	NLRC5	chr16	57079404	+	FTO	chr16	54145674	+
96672	ESCA	TCGA-2H-A9GH	NLRC5	chr16	57080553	+	FTO	chr16	54145673	+
96672	ESCA	TCGA-2H-A9GH-01A	NLRC5	chr16	57080553	+	FTO	chr16	54145674	+
96672	LUAD	TCGA-55-6712-01A	PHIP	chr6	79752560	-	FTO	chr16	54145674	+
96672	LGG	TCGA-TM-A84I-01A	ST8SIA1	chr12	22401940	-	FTO	chr16	54145674	+
96673	N/A	T05729	UGT2B7	chr4	69969008	-	FTO	chr16	54146782	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type

Translation factor

pval

adj.p

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	FTO	0.0439229673735446	1
LUAD	FTO	0.0348275014480523	0.91
LGG	FTO	0.000280455492746405	0.0093
LAML	FTO	0.0164492676625397	0.46
BRCA	FTO	0.00849752131923942	0.26
UCEC	FTO	0.00918003362310389	0.28
ESCA	FTO	0.0300002445054722	0.81
THYM	FTO	0.0091875484051698	0.28
SARC	FTO	0.00544249643531456	0.17

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0028754	Obesity	6	CTD_human
C2752001	Growth Retardation, Developmental Delay, Coarse Facies, And Early Death	4	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
C0001973	Alcoholic Intoxication, Chronic	3	PSYGENET
C0011581	Depressive disorder	3	PSYGENET
C0011570	Mental Depression	2	PSYGENET
C0006142	Malignant neoplasm of breast	1	CTD_human
C0011860	Diabetes Mellitus, Non-Insulin-Dependent	1	CTD_human
C0025202	melanoma	1	CTD_human
C0678222	Breast Carcinoma	1	CTD_human
C1257931	Mammary Neoplasms, Human	1	CTD_human
C2362324	Pediatric Obesity	1	CTD_human
C4704874	Mammary Carcinoma, Human	1	CTD_human