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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: FXR1 (NCBI Gene ID:8087)

Gene Summary

Gene Summary

Gene Information	Gene Name: FXR1
	Gene ID: 8087
	Gene Symbol	FXR1
	Gene ID	8087
	Gene Name	FMR1 autosomal homolog 1
	Synonyms	FXR1P
	Cytomap	3q26.33
	Type of Gene	protein-coding
	Description	fragile X mental retardation syndrome-related protein 1fragile X mental retardation, autosomal homolog 1
	Modification date	20200320
	UniProtAcc	P51114

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0045727	Positive regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	FXR1	GO:2000637	positive regulation of gene silencing by miRNA	17057366

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'FXR1[title] AND translation [title] AND human.'

Gene	Title	PMID
FXR1	RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site	34731628

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000357559	180651121	180651174	Frame-shift
ENST00000357559	180652925	180653019	Frame-shift
ENST00000357559	180666508	180666602	Frame-shift
ENST00000357559	180669085	180669256	In-frame
ENST00000357559	180671549	180671628	Frame-shift
ENST00000357559	180687945	180688146	In-frame
ENST00000357559	180693100	180693192	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000357559	180669085	180669256	8728	1015	1185	621	210	267
ENST00000357559	180687945	180688146	8728	1787	1987	621	467	534

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P51114	467	534	2	621	Chain	ID=PRO_0000050106;Note=Fragile X mental retardation syndrome-related protein 1
P51114	210	267	2	621	Chain	ID=PRO_0000050106;Note=Fragile X mental retardation syndrome-related protein 1
P51114	210	267	222	251	Domain	Note=KH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00117
P51114	467	534	502	510	Compositional bias	Note=Poly-Arg
P51114	467	534	483	483	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q61584
P51114	467	534	485	485	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:21406692;Dbxref=PMID:21406692
P51114	467	534	524	524	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P51116
P51114	210	267	233	233	Natural variant	ID=VAR_036050;Note=In a breast cancer sample%3B somatic mutation. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
P51114	210	267	213	216	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2CPQ
P51114	210	267	218	224	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2CPQ
P51114	210	267	227	234	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2CPQ
P51114	210	267	239	245	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2CPQ
P51114	210	267	250	256	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2CPQ
P51114	210	267	257	260	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2CPQ
P51114	210	267	261	268	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2CPQ

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LIHC	FXR1	-1.34222849900153	0.00221270975997039
HNSC	FXR1	1.42033860536739	0.03633773249976
KIRC	FXR1	-1.91678508891597	7.23860956542035e-06
LUAD	FXR1	-1.55340065062105	7.61068774930263e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
DLBC	FXR1	hsa-miR-30d-5p	90	0.318695614599365	0.0290126404415918
OV	FXR1	hsa-miR-30d-5p	90	-0.309143686502177	0.0261543578191528
UCEC	FXR1	hsa-miR-30b-5p	90	0.381512605042017	0.026693036187154

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
COAD	FXR1	-0.018938204	0.009831246
TGCT	FXR1	0.098351481	0.027742885
STAD	FXR1	0.069055112	0.034080068

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with FXR1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
LUSC	Cell metabolism gene	FXR1	PSMD2	0.804459992	9.65E-127
LUSC	Epifactor	FXR1	ACTL6A	0.802331068	1.38E-125
LUSC	TF	FXR1	ZNF639	0.826684216	1.00E-139
THYM	Epifactor	FXR1	YY1	0.804660396	6.10E-29
THYM	TF	FXR1	YY1	0.804660396	6.10E-29
UCS	Epifactor	FXR1	YY1	0.804660396	6.10E-29
UCS	TF	FXR1	YY1	0.804660396	6.10E-29
UVM	Cell metabolism gene	FXR1	PIK3R4	0.81643339	2.74E-20
UVM	Cell metabolism gene	FXR1	TOMM70A	0.877698587	1.23E-26
UVM	CGC	FXR1	SETD2	0.812063001	6.27E-20
UVM	CGC	FXR1	MLF1	0.812082887	6.25E-20
UVM	Epifactor	FXR1	NAP1L1	0.801465586	4.29E-19
UVM	Epifactor	FXR1	ACTL6A	0.804186521	2.65E-19
UVM	Epifactor	FXR1	SETD2	0.812063001	6.27E-20
UVM	Epifactor	FXR1	SETD5	0.813066343	5.19E-20
UVM	Epifactor	FXR1	MBD4	0.822547301	8.27E-21
UVM	Epifactor	FXR1	SETMAR	0.824264586	5.86E-21
UVM	Epifactor	FXR1	RYBP	0.840239533	1.96E-22
UVM	Epifactor	FXR1	MSL2	0.84723451	3.94E-23
UVM	IUPHAR	FXR1	ACVR2B	0.8094628	1.02E-19
UVM	IUPHAR	FXR1	SETD2	0.812063001	6.27E-20
UVM	IUPHAR	FXR1	ATP13A3	0.814117982	4.26E-20
UVM	IUPHAR	FXR1	PIK3R4	0.81643339	2.74E-20
UVM	IUPHAR	FXR1	ATP2C1	0.819264384	1.58E-20
UVM	IUPHAR	FXR1	SLC35A5	0.828683592	2.37E-21
UVM	Kinase	FXR1	ACVR2B	0.8094628	1.02E-19
UVM	Kinase	FXR1	PIK3R4	0.81643339	2.74E-20
UVM	TF	FXR1	ZNF621	0.820807045	1.17E-20
UVM	TF	FXR1	MBD4	0.822547301	8.27E-21
UVM	TF	FXR1	ZNF197	0.867255335	2.45E-25
UVM	TSG	FXR1	SETD2	0.812063001	6.27E-20
UVM	TSG	FXR1	MBD4	0.822547301	8.27E-21

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
STAD	FXR1	CAMK2D	-1.40591518113083	0.000177780166268349
COAD	FXR1	CAMK2B	1.17180359167146	0.000590741634368897
KICH	FXR1	FMR1	1.78310178813069	0.00102710723876953
STAD	FXR1	CAMK2G	-2.52467153772892	0.00222697434946895
CHOL	FXR1	CYFIP1	-2.7780697871673	0.0078125
KIRP	FXR1	FMR1	-1.94284822624948	0.0099095250479877
THCA	FXR1	CYFIP2	1.90181293917412	0.0176042512051157
READ	FXR1	CAMK2G	-2.76002520037754	0.03125
COAD	FXR1	FXR2	1.01105544222868	0.0407472252845765
BRCA	FXR1	FMR1	-2.74053611255086	0.0481383834499222
KIRC	FXR1	FMR1	-2.35406916543664	1.12145348829767e-07
HNSC	FXR1	FMR1	-2.72606987034586	1.37760207508109e-06
BRCA	FXR1	CYFIP2	-1.47325685264116	1.38509705928293e-11
PRAD	FXR1	CYFIP1	-1.10818424355985	1.48880035272649e-05
PRAD	FXR1	CAMK2G	-2.33398439635804	1.514182192573e-08
STAD	FXR1	CAMK2B	2.05001414315204	2.0815059542656e-07
COAD	FXR1	CAMK2D	-2.30179778619578	3.27825546264649e-06
KIRP	FXR1	CYFIP2	-1.46566210299983	4.6566128730774e-10
KICH	FXR1	CAMK2G	2.51759921698051	5.38825988769531e-05
BRCA	FXR1	CYFIP1	-1.13433942711589	5.44928403979541e-07
KIRC	FXR1	TDRD3	1.02423146098262	6.53197063696712e-05
KIRC	FXR1	CAMK2G	1.79647725872487	6.53264115309597e-07
PRAD	FXR1	CAMK2D	-4.02991735419794	7.88567132343024e-05
COAD	FXR1	CAMK2G	-2.5329743045289	9.14931297302247e-06

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with FXR1

FMR1, CYFIP2, CRMP1, GBP2, KIAA1377, C14orf1, LUC7L2, LRIF1, PRSS23, FXR2, CYFIP1, FXR1, GIGYF2, HDAC5, ELAVL1, SIRT7, TDRD3, CUL3, COPS5, CAND1, CSNK2A1, CAPRIN1, LRWD1, ORC2, RANBP9, TOP3B, UBAP2, CUL7, CCDC8, SUZ12, BMI1, WDR76, MAGEA4, PINX1, LUC7L, Numb, HSPB1, NTRK1, IFI16, CCNA2, CCNB1, CLU, CDK18, PRKCD, SNCA, TSNAX, BCLAF1, THOC1, NOP56, PLK2, CCDC93, UBA6, THOC2, SLAIN2, MYH7B, TUBA1C, CEP170P1, Stmn1, Max, Mtx1, Sart3, Samm50, Slain2, Tubg1, Spred2, Bag2, Klc3, GLI1, FOXQ1, FOXS1, NFATC1, LGALS3BP, RRP8, PLEKHO1, ZNF512, G3BP1, FBXO4, SKP1, CUL1, RBX1, GSK3B, CLEC14A, WDR77, API5, GSK3A, TRIP4, EFTUD2, BPLF1, EZH2, RECQL4, ZBTB38, MYC, RNF41, C1orf106, RC3H1, RC3H2, ATG16L1, PHB, PRKD2, USP14, NR2C2, UCHL3, ZBTB10, HDAC2, PRDM16, SNRNP70, MDP1, PTP4A1, PTP4A2, PTPDC1, BIRC3, STAU1, UBAP2L, WWP2, BRD7, TRIM28, CMTR1, CDKL3, TCEB3, TBC1D22B, LNX1, AP1M1, KIF9, CDC7, PRPF31, SUFU, DHX15, DDX6, MAGOHB, BYSL, STK16, PRAM1, TRPM1, SYT6, SRPK2, BLK, MFAP1, CBX8, C1orf35, ZMAT2, CWF19L2, MAGOH, FAM161A, ESCO2, TCEA2, FAM90A1, ZNF417, YES1, ZNF438, MCRS1, ZNF71, MGC50722, PLEKHA4, KCTD10, PINK1, ORF9b, DUSP6, FGR, GRB10, HCK, PRKD1, SOCS1, EMC1, HIST1H1B, HIST1H1C, N, nsp3, nsp9, HTRA2, IMMP1L, IMMP2L, ERCC6, ALG13, ANKHD1-EIF4EBP3, ANKRD17, AP2A1, AP2A2, AP2B1, AP2M1, ATXN2, C1QBP, CSDE1, EIF4ENIF1, FAM120A, G3BP2, GLE1, LUZP1, OTUD4, PRMT1, PRRC2A, PRRC2B, PRRC2C, SMG1, TNRC6B, YTHDF2, ZC3H7A, ZC3H7B, AGO2, ANKHD1, ATXN2L, FUBP3, HELZ, KIAA1671, LARP4B, LSM12, LSM14A, FAM195B, FAM195A, MIA3, NFX1, NUFIP2, PABPC4, PUM1, RBMS1, RNF214, SECISBP2, SMG5, SMG6, SMG7, UPF1, UPF2, UPF3B, USP10, YTHDF1, YTHDF3, ZNF598, ZC3HAV1, STRAP, AGO1, CAPRIN2, CPEB4, DDX1, DHX57, LARP1B, LARP4, R3HDM1, TTK, MEX3B, DDX3X, KIF14, DDX50, OCRL, ZCCHC11, CIT, ANLN, AURKB, CHMP4C, KIF20A, KIF23, PRC1, CECR2, LDLR, HNRNPH1, nsp8ab, LRRC59, MAFB, BRD4, NUPR1, RBM39, CUL4A, RIN3, TPD52L2, SDCCAG8, SPOP, AR, UFL1, DDRGK1, RPS20, SERBP1, TRIM37, HTRA4, FZR1, SEPT2, ABI1, ACLY, ACOT7, ACTB, ACTG1, ACTN1, ACTN2, ADAMTSL4, AES, ALAS1, ANKRD40, ANKS3, APC2, ARHGAP22, ARHGEF7, ATN1, AXIN1, AXIN2, BCKDK, BEND5, BHLHE40, BICD1, BTBD2, BTBD6, FAM208B, VPS51, KIAA1549L, CACTIN-AS1, C5orf42, MSANTD3, CA10, CALCOCO1, CAMK2A, CAMK2B, CAMK2G, CAPN3, CBS, CCBE1, CEP89, CCDC92, CDC123, CDR2, CDYL, CEP72, CHRD, CIR1, COIL, CORO1A, CORO1B, CORO6, CSNK2B, CYHR1, SPECC1, DCTD, DCTN1, DCTN2, DCTPP1, DEAF1, DNAJA3, DNM2, ECH1, ECHS1, ECM1, EDC4, EFEMP2, PCED1A, PAFAH1B3, PAICS, EGFL7, EIF3A, EML1, ENO1, EVL, FBLN1, FLAD1, FLNA, FLNB, FTH1, GFAP, GOLGA2, GOLGA3, GPSM2, GRIP1, GRIP2, GRIPAP1, ERVFRD-1, HIVEP1, HLA-DRB5, HMG20A, HNRNPH2, HNRNPM, HNRNPUL1, HOMER2, HOMER3, HPRT1, IK, IMPDH2, INA, JAKMIP1, KCNN1, KCTD1, KCTD13, KHDRBS1, KHDRBS3, MTUS2, KAZN, CCAR2, KIF17, KRT18, LAP3, LRSAM1, LZTS2, MAD1L1, MAGED1, MAPK7, MAPK8IP3, MAPKBP1, MBIP, MLLT1, MOAP1, MVP, MX1, MYH10, MYH9, MYO5B, GLYR1, N4BP3, NBPF15, NECAB2, NECAB3, NEFL, NKD2, NME1, NME1-NME2, NME3, NONO, NOV, PCCB, PDE9A, AHCY, PHC1P1, PHC2, PHLDB1, PKM, PML, PNMA1, PPHLN1, PPP1R12C, PRKCSH, PRR13, PSMC3, PSMC5, PSME1, PSME3, PSPC1, PYCR1, PYCR2, PYCRL, RABAC1, RALYL, RBM26, RBM45, RPIA, RUSC2, SAFB2, SAMD1, SCMH1, SERTAD1, SF3B2, SFPQ, SH3GL2, SH3GLB2, SHANK1, SHARPIN, SLC48A1, SLIT1, SNURF, SORBS3, SOX5, SPRY1, SPRY2, SSNA1, STUB1, TACC2, TDRD7, TMPO, TNFAIP1, TNIP1, TP53, TRAF2, TRAP1, TRIM3, TRIOBP, TSN, TTLL5, TUBB, UBP1, UHRF1BP1L, UXS1, VIM, VWF, WASH6P, WRNIP1, YY1AP1, ZNF212, ZNF423, ZNF821, WDR5, NUDCD2, ZBTB2, TRAF7, SRSF6, GPSM3, ZBTB3, CD6, C10orf88, USP11, BTF3, ESR1, EP300, FBXW7, nsp13, CCNF, SIRT6, PKP3,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
FXR1	chr3	180630500	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant	SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant
FXR1	chr3	180651115	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FXR1	chr3	180665701	A	G	single_nucleotide_variant	Uncertain_significance	Congenital_myopathy	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant
FXR1	chr3	180666210	A	G	single_nucleotide_variant	Uncertain_significance	Congenital_myopathy	SO:0001583\|missense_variant	SO:0001583\|missense_variant
FXR1	chr3	180666557	A	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
FXR1	chr3	180669208	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
FXR1	chr3	180679327	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
FXR1	chr3	180688871	GA	G	Deletion	Uncertain_significance	Multiminicore_Disease\|Myopathy,_congenital_proximal,_with_minicore_lesions	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FXR1	chr3	180688933	TAGAC	T	Deletion	Pathogenic	Myopathy,_congenital,_with_respiratory_insufficiency_and_bone_fractures	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FXR1	chr3	180693182	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
FXR1	chr3	180693986	T	A	single_nucleotide_variant	Likely_pathogenic	Intellectual_disability	SO:0001583\|missense_variant,SO:0001624\|3_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001624\|3_prime_UTR_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
FXR1	LUAD	chr3	180671582	180671582	C	T	Silent	p.F278F	7
FXR1	ACC	chr3	180666228	180666228	A	-	Frame_Shift_Del	p.K123fs	6
FXR1	UCEC	chr3	180687964	180687964	G	A	Missense_Mutation	p.S474N	5
FXR1	HNSC	chr3	180685989	180685989	C	T	Missense_Mutation	p.S450L	5
FXR1	STAD	chr3	180685947	180685947	G	A	Missense_Mutation	p.R436H	4
FXR1	BRCA	chr3	180669241	180669241	C	A	Missense_Mutation	p.F262L	4
FXR1	ESCA	chr3	180666281	180666281	G	T	Missense_Mutation	p.E139D	4
FXR1	BRCA	chr3	180694051	180694051	G	C	Missense_Mutation	p.E613Q	4
FXR1	LIHC	chr3	180675620	180675620	A	-	Frame_Shift_Del	p.G298fs	4
FXR1	BLCA	chr3	180688077	180688077	G	A	Missense_Mutation	p.D512N	4
FXR1	ESCA	chr3	180652996	180652996	A	G	Missense_Mutation	p.I59V	3
FXR1	ESCA	chr3	180688017	180688017	G	A	Missense_Mutation	p.D492N	3
FXR1	ESCA	chr3	180693971	180693971	C	T	Missense_Mutation	p.A586V	3
FXR1	ACC	chr3	180687983	180687983	T	A	Silent	p.L480L	3
FXR1	UCEC	chr3	180667086	180667086	G	T	Missense_Mutation	p.K195N	3
FXR1	BLCA	chr3	180630521	180630521	C	T	Silent	p.Y16Y	3
FXR1	BRCA	chr3	180675642	180675642	G	C	Missense_Mutation	p.E306Q	3
FXR1	HNSC	chr3	180685868	180685868	G	A	Missense_Mutation	p.E410K	3
FXR1	UCEC	chr3	180652940	180652940	G	A	Missense_Mutation	p.R40H	3
FXR1	BRCA	chr3	180686028	180686031	CCTC	-	Frame_Shift_Del	p.I465fs	3
FXR1	SKCM	chr3	180685959	180685959	G	T	Missense_Mutation	p.R440I	3
FXR1	CESC	chr3	180667078	180667078	C	T	Missense_Mutation		2
FXR1	LUAD	chr3	180675675	180675675	A	T	Nonsense_Mutation	p.R317*	2
FXR1	BLCA	chr3	180688077	180688077	G	A	Missense_Mutation		2
FXR1	BRCA	chr3	180680687	180680687	G	C	Missense_Mutation	p.R365T	2
FXR1	ESCA	chr3	180686015	180686015	C	T	Missense_Mutation	p.R459C	2
FXR1	LIHC	chr3	180652986	180652986	A	-	Frame_Shift_Del	p.I55fs	2
FXR1	UCEC	chr3	180667070	180667070	G	A	Missense_Mutation	p.R190Q	2
FXR1	CESC	chr3	180685897	180685897	G	C	Silent		2
FXR1	STAD	chr3	180666158	180666158	T	A	Silent	p.A98A	2
FXR1	BRCA	chr3	180680780	180680780	A	G	Missense_Mutation	p.Y311C	2
FXR1	SARC	chr3	180680695	180680695	C	T	Missense_Mutation	p.R368C	2
FXR1	UCEC	chr3	180671565	180671565	A	C	Missense_Mutation	p.K273Q	2
FXR1	STAD	chr3	180693938	180693938	C	T	Missense_Mutation	p.P575L	2
FXR1	ACC	chr3	180666228	180666228	A	-	Frame_Shift_Del	p.V121fs	2
FXR1	CESC	chr3	180688094	180688094	G	A	Silent		2
FXR1	KICH	chr3	180666228	180666228	A	-	Frame_Shift_Del	p.K122fs	2
FXR1	LUAD	chr3	180693108	180693108	T	C	Silent	p.V537V	2
FXR1	BRCA	chr3	180685879	180685879	T	G	Missense_Mutation	p.L14R	2
FXR1	HNSC	chr3	180651167	180651167	G	C	Missense_Mutation	p.E33Q	2
FXR1	LIHC	chr3	180666565	180666565	T	-	Frame_Shift_Del	p.I159fs	2
FXR1	SKCM	chr3	180680855	180680855	G	A	Missense_Mutation	p.G392E	2
FXR1	UCEC	chr3	180671577	180671577	G	A	Missense_Mutation	p.G277S	2
FXR1	STAD	chr3	180666230	180666230	A	G	Silent	p.K122K	2
FXR1	ACC	chr3	180685937	180685937	C	T	Nonsense_Mutation	p.R433X	2
FXR1	CESC	chr3	180666162	180666162	G	C	Missense_Mutation	p.D100H	2
FXR1	BLCA	chr3	180693957	180693957	C	T	Silent	p.N581N	2
FXR1	HNSC	chr3	180688116	180688116	G	A	Missense_Mutation	p.D525N	2
FXR1	LIHC	chr3	180671564	180671564	A	-	Frame_Shift_Del	p.V272fs	2
FXR1	UCEC	chr3	180671624	180671624	C	T	Silent	p.L292	2
FXR1	STAD	chr3	180686004	180686004	G	A	Missense_Mutation	p.R455H	2
FXR1	UCEC	chr3	180675717	180675717	G	A	Splice_Site	e10+1	2
FXR1	STAD	chr3	180688056	180688056	C	T	Missense_Mutation	p.R505W	2
FXR1	BLCA	chr3	180666136	180666136	T	A	Splice_Site	p.F91Y	2
FXR1	ESCA	chr3	180688017	180688017	G	A	Missense_Mutation		2
FXR1	UCEC	chr3	180688137	180688137	A	C	Missense_Mutation	p.N532H	2
FXR1	STAD	chr3	180666236	180666236	T	A	Missense_Mutation	p.N124K	2
FXR1	ESCA	chr3	180686015	180686015	C	T	Missense_Mutation		2
FXR1	LIHC	chr3	180666135	180666135	T	-	Splice_Site	p.F91_splice	2
FXR1	STAD	chr3	180685947	180685947	G	A	Missense_Mutation		2
FXR1	UCEC	chr3	180693112	180693112	G	T	Missense_Mutation	p.D539Y	2
FXR1	STAD	chr3	180669105	180669105	C	T	Missense_Mutation	p.A217V	2
FXR1	COAD	chr3	180666227	180666228	-	A	Frame_Shift_Ins	p.V121fs	2
FXR1	ESCA	chr3	180633391	180633391	G	T	Missense_Mutation		2
FXR1	LIHC	chr3	180671587	180671587	A	-	Frame_Shift_Del	p.E280fs	2
FXR1	CESC	chr3	180666162	180666162	G	C	Missense_Mutation		2
FXR1	STAD	chr3	180666158	180666158	T	A	Silent		2
FXR1	STAD	chr3	180666221	180666221	A	G	Silent	p.K119K	2
FXR1	BLCA	chr3	180675620	180675620	A	G	Silent	p.G298G	2
FXR1	ESCA	chr3	180693971	180693971	C	T	Missense_Mutation		2
FXR1	PAAD	chr3	180666195	180666195	C	T	Nonsense_Mutation	p.R111*	2
FXR1	UCEC	chr3	180666165	180666165	G	A	Missense_Mutation	p.A101T	2
FXR1	HNSC	chr3	180685878	180685878	C	G	Missense_Mutation	p.S413C	2
FXR1	STAD	chr3	180693938	180693938	C	T	Missense_Mutation		2
FXR1	ESCA	chr3	180652996	180652996	A	G	Missense_Mutation		2
FXR1	LIHC	chr3	180679300	180679300	A	-	Frame_Shift_Del	p.G345fs	2
FXR1	UCEC	chr3	180666201	180666201	C	T	Missense_Mutation	p.R113W	2
FXR1	LUAD	chr3	180675674	180675674	G	T	Silent	p.V316V	2
FXR1	STAD	chr3	180666230	180666230	A	G	Silent		2
FXR1	SARC	chr3	180680695	180680695	C	T	Missense_Mutation		2
FXR1	UCEC	chr3	180666525	180666525	G	A	Missense_Mutation	p.A146T	2
FXR1	HNSC	chr3	180688083	180688083	G	C	Missense_Mutation	p.D514H	1
FXR1	PAAD	chr3	180675681	180675681	G	C	Missense_Mutation	p.E319Q	1
FXR1	THYM	chr3	180667110	180667110	A	G	Silent		1
FXR1	DLBC	chr3	180630500	180630500	C	T	Silent	p.R9R	1
FXR1	LIHC	chr3	180669246	180669246	T	C	Missense_Mutation		1
FXR1	LUSC	chr3	180667070	180667070	G	T	Missense_Mutation	p.R190L	1
FXR1	HNSC	chr3	180688083	180688083	G	C	Missense_Mutation		1
FXR1	SARC	chr3	180693977	180693977	G	T	Missense_Mutation		1
FXR1	HNSC	chr3	180666565	180666565	T	A	Missense_Mutation	p.I159N	1
FXR1	LUAD	chr3	180667013	180667013	A	T	Splice_Site		1
FXR1	LUSC	chr3	180671624	180671624	C	A	Silent	p.L292L	1
FXR1	PAAD	chr3	180666195	180666195	C	T	Nonsense_Mutation		1
FXR1	THYM	chr3	180669087	180669087	G	T	Missense_Mutation		1
FXR1	BLCA	chr3	180680720	180680720	G	T	Missense_Mutation		1
FXR1	LIHC	chr3	180666213	180666213	C	A	Missense_Mutation		1
FXR1	GBM	chr3	180651171	180651172	AT	-	Frame_Shift_Del	p.N34fs	1
FXR1	HNSC	chr3	180669130	180669130	G	A	Silent		1
FXR1	LIHC	chr3	180666178	180666178	A	-	Frame_Shift_Del	p.E105fs	1
FXR1	LIHC	chr3	180675611	180675611	A	G	Silent		1
FXR1	MESO	chr3	180680869	180680869	T	C	Missense_Mutation	p.S397P	1
FXR1	PCPG	chr3	180630496	180630496	T	G	Missense_Mutation		1
FXR1	THYM	chr3	180688063	180688063	G	T	Missense_Mutation	p.R507L	1
FXR1	BLCA	chr3	180685929	180685929	G	A	Missense_Mutation		1
FXR1	HNSC	chr3	180688116	180688116	G	A	Missense_Mutation		1
FXR1	KIRP	chr3	180688019	180688019	T	C	Silent	p.D492D	1
FXR1	LUAD	chr3	180630498	180630498	C	T	Missense_Mutation	p.R9C	1
FXR1	LIHC	chr3	180666144	180666144	A	G	Missense_Mutation	p.I94V	1
FXR1	OV	chr3	182163519	182163519	C	T	Missense_Mutation	p.S382F	1
FXR1	PCPG	chr3	180630496	180630496	T	G	Missense_Mutation	p.V8G	1
FXR1	THYM	chr3	180667110	180667110	A	G	Silent	p.E203E	1
FXR1	HNSC	chr3	180651167	180651167	G	C	Missense_Mutation		1
FXR1	SKCM	chr3	180685857	180685857	C	T	Missense_Mutation	p.S406F	1
FXR1	CESC	chr3	180666275	180666275	G	G	Missense_Mutation		1
FXR1	KIRP	chr3	180693192	180693192	G	C	Missense_Mutation	p.M565I	1
FXR1	LUAD	chr3	180675715	180675718	ACGT	-	Splice_Site	p.330_splice	1
FXR1	LIHC	chr3	180666182	180666182	A	T	Silent	p.I106I	1
FXR1	OV	chr3	182168562	182168563	-	A	Frame_Shift_Ins	p.T411fs	1
FXR1	PRAD	chr3	180675619	180675620	-	A	Frame_Shift_Ins	p.G298fs	1
FXR1	HNSC	chr3	180666565	180666565	T	A	Missense_Mutation		1
FXR1	LIHC	chr3	180680826	180680826	T	-	Frame_Shift_Del	p.S382fs	1
FXR1	SKCM	chr3	180688101	180688101	G	A	Missense_Mutation	p.G520R	1
FXR1	ACC	chr3	180685937	180685937	C	T	Nonsense_Mutation	p.R433*	1
FXR1	CESC	chr3	180666275	180666275	G	C	Missense_Mutation	p.L137F	1
FXR1	LGG	chr3	180685891	180685891	C	T	Silent	p.D417D	1
FXR1	LUAD	chr3	180675674	180675675	GA	TT	Nonsense_Mutation	p.R317*	1
FXR1	LIHC	chr3	180652981	180652981	G	T	Missense_Mutation	p.D54Y	1
FXR1	OV	chr3	182168663	182168663	A	T	Silent	p.G443	1
FXR1	PRAD	chr3	180675619	180675620	-	A	Frame_Shift_Ins	p.E298fs	1
FXR1	HNSC	chr3	180693130	180693130	G	A	Missense_Mutation		1
FXR1	HNSC	chr3	180669130	180669130	G	A	Silent	p.V225V	1
FXR1	LIHC	chr3	180693164	180693164	A	-	Frame_Shift_Del	p.E556fs	1
FXR1	CESC	chr3	180688094	180688094	G	A	Silent	p.L517	1
FXR1	LGG	chr3	180652995	180652995	A	G	Silent	p.E58E	1
FXR1	LUAD	chr3	180667013	180667013	A	T	Splice_Site	p.S172_splice	1
FXR1	PAAD	chr3	180666228	180666228	A	-	Frame_Shift_Del		1
FXR1	READ	chr3	180675611	180675611	A	G	Silent	p.K295K	1
FXR1	BLCA	chr3	180686040	180686040	C	A	Missense_Mutation	p.S467Y	1
FXR1	HNSC	chr3	180688142	180688142	G	T	Silent		1
FXR1	HNSC	chr3	180693130	180693130	G	A	Missense_Mutation	p.E545K	1
FXR1	LIHC	chr3	180671579	180671579	T	-	Frame_Shift_Del	p.G277fs	1
FXR1	BLCA	chr3	180693957	180693957	C	T	Silent		1
FXR1	LGG	chr3	180652995	180652995	A	G	Silent		1
FXR1	LUSC	chr3	180671549	180671549	G	A	Splice_Site	p.S268_splice	1
FXR1	BLCA	chr3	180675669	180675669	C	T	Nonsense_Mutation	p.R315*	1
FXR1	PAAD	chr3	180666195	180666195	C	T	Nonsense_Mutation	p.R111X	1
FXR1	READ	chr3	180693163	180693163	G	T	Nonsense_Mutation	p.E471X	1
FXR1	UCEC	chr3	180666208	180666208	T	A	Missense_Mutation	p.V115D	1
FXR1	HNSC	chr3	180685878	180685878	C	G	Missense_Mutation		1
FXR1	LIHC	chr3	180651162	180651162	T	-	Frame_Shift_Del	p.V31fs	1
FXR1	BLCA	chr3	180630521	180630521	C	T	Silent		1
FXR1	COAD	chr3	180679287	180679287	A	C	Missense_Mutation	p.K341T	1
FXR1	LGG	chr3	180685891	180685891	C	T	Silent		1
FXR1	LUSC	chr3	180685922	180685922	G	A	Missense_Mutation	p.D428N	1
FXR1	SARC	chr3	180685945	180685945	G	T	Missense_Mutation		1
FXR1	CESC	chr3	180645436	180645436	G	T	Missense_Mutation		1
FXR1	HNSC	chr3	180685868	180685868	G	A	Missense_Mutation		1
FXR1	STAD	chr3	180688129	180688129	T	C	Missense_Mutation	p.V529A	1
FXR1	BLCA	chr3	180686040	180686040	C	A	Missense_Mutation		1
FXR1	COAD	chr3	180680833	180680833	G	A	Missense_Mutation	p.G385R	1
FXR1	LIHC	chr3	180630500	180630500	C	T	Silent		1
FXR1	LUSC	chr3	180630511	180630511	G	T	Missense_Mutation	p.G13V	1
FXR1	SARC	chr3	180630401	180630401	C	T	Missense_Mutation		1
FXR1	CESC	chr3	180633392	180633392	T	G	Silent		1
FXR1	HNSC	chr3	180685989	180685989	C	T	Missense_Mutation		1
FXR1	HNSC	chr3	180688142	180688142	G	T	Silent	p.G533G	1
FXR1	PAAD	chr3	180688069	180688069	G	A	Missense_Mutation	p.R509Q	1
FXR1	STAD	chr3	180680862	180680862	T	C	Silent	p.N394N	1
FXR1	BLCA	chr3	180675620	180675620	A	G	Silent		1
FXR1	COAD	chr3	180693959	180693959	G	A	Missense_Mutation	p.G497D	1
FXR1	LIHC	chr3	180693929	180693929	A	G	Missense_Mutation		1
FXR1	LUSC	chr3	180671612	180671612	T	A	Silent	p.V288V	1
FXR1	BLCA	chr3	180685929	180685929	G	A	Missense_Mutation	p.R430Q	1
FXR1	ESCA	chr3	180669108	180669108	C	A	Missense_Mutation	p.A218D	1
FXR1	LIHC	chr3	180652951	180652951	T	-	Frame_Shift_Del	p.F44fs	1

Copy number variation (CNV) of FXR1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across FXR1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
98071	LUSC	TCGA-56-7823	ATP11B	chr3	182511574	+	FXR1	chr3	180685838	+
98071	LUSC	TCGA-56-7823-01B	ATP11B	chr3	182511574	+	FXR1	chr3	180685839	+
98071	N/A	AV746723	C18orf25	chr18	43833786	+	FXR1	chr3	180693914	+
97592	N/A	BU566094	FXR1	chr3	180653010	+	C6orf106	chr6	34555144	-
87299	N/A	AA625344	FXR1	chr3	180633869	-	CTSA	chr20	44520937	+
101817	N/A	DN919453	FXR1	chr3	180697323	-	EYS	chr6	66194922	-
92935	LUSC	TCGA-63-A5MV-01A	FXR1	chr3	180630524	+	FGF10	chr5	44389158	-
99952	LUSC	TCGA-52-7622-01A	FXR1	chr3	180675716	+	KLHL24	chr3	183361268	+
99952	N/A	DA402481	FXR1	chr3	180632785	+	KLHL24	chr3	183361265	+
91556	LUSC	TCGA-85-8580-01A	FXR1	chr3	180630524	+	MCCC1	chr3	182790275	-
95979	N/A	MF125244	FXR1	chr3	180630524	+	MYC	chr8	128750492	+
84715	CESC	TCGA-C5-A1ML-01A	FXR1	chr3	180653019	+	NAALADL2	chr3	175165017	+
101218	STAD	TCGA-CD-8530-01A	FXR1	chr3	180630524	+	PPM1B	chr2	44459455	+
79800	BRCA	TCGA-A8-A09G	FXR1	chr3	180630524	+	PROS1	chr3	93629549	-
88324	N/A	BF216985	FXR1	chr3	180652992	+	REPS2	chrX	17074127	+
102166	BRCA	TCGA-C8-A135-01A	FXR1	chr3	180651174	+	RIMS2	chr8	105080740	+
67568	LUAD	TCGA-50-6595-01A	FXR1	chr3	180675716	+	RPH3A	chr12	113155811	+
98994	OV	TCGA-61-2016	FXR1	chr3	180630524	+	ST6GAL1	chr3	186756529	+
98994	OV	TCGA-61-2016-01A	FXR1	chr3	180630524	+	ST6GAL1	chr3	186756530	+
43220	OV	TCGA-24-1550	FXR1	chr3	180630524	+	TTC14	chr3	180320678	+
43220	OV	TCGA-24-1550-01A	FXR1	chr3	180630524	+	TTC14	chr3	180319946	+
43220	OV	TCGA-24-1550-01A	FXR1	chr3	180630524	+	TTC14	chr3	180320679	+
98085	BRCA	TCGA-A2-A0CM	FXR1	chr3	180630524	+	VGLL4	chr3	11606493	-
101156	BRCA	TCGA-BH-A203-01A	FXR1	chr3	180630524	+	ZFYVE16	chr5	79768580	+
98071	N/A	AW451314	IGFBP2	chr2	217529091	-	FXR1	chr3	180688173	-
98071	LUSC	TCGA-56-7223	MCCC1	chr3	182788786	-	FXR1	chr3	180679255	+
98071	LUSC	TCGA-56-7223-01A	MCCC1	chr3	182788787	-	FXR1	chr3	180679256	+
98071	N/A	AX193087	POTEI	chr2	132202389	-	FXR1	chr3	180630473	+
98071	STAD	TCGA-BR-8284-01A	PRKCA	chr17	64785097	+	FXR1	chr3	180693101	+
98071	N/A	EF580607	STAM	chr10	17714117	-	FXR1	chr3	180677497	-
98071	LUSC	TCGA-85-8355	USP13	chr3	179371181	+	FXR1	chr3	180651122	+
98071	LUSC	TCGA-85-8355	USP13	chr3	179399791	+	FXR1	chr3	180651121	+
98071	LUSC	TCGA-85-8355	USP13	chr3	179399791	+	FXR1	chr3	180651122	+
98085	BRCA	TCGA-A2-A0CM-01A	VGLL4	chr3	11744445	-	FXR1	chr3	180651122	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRP	FXR1	0.00140062767125864	0.038
SARC	FXR1	0.00344568120392429	0.09
TGCT	FXR1	0.00758045736063792	0.19
LUSC	FXR1	0.0140347526433128	0.34
HNSC	FXR1	7.96625454209049e-05	0.0022

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LAML	FXR1	0.0348299900585868	1
BRCA	FXR1	0.00688125971706374	0.22
UCEC	FXR1	0.0299434515873239	0.9
ESCA	FXR1	2.49241296192648e-05	0.00082
SARC	FXR1	0.0247875930912812	0.77

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source