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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: SESN2 (NCBI Gene ID:83667)

Gene Summary

Gene Summary

Gene Information	Gene Name: SESN2
	Gene ID: 83667
	Gene Symbol	SESN2
	Gene ID	83667
	Gene Name	sestrin 2
	Synonyms	HI95\|SES2\|SEST2
	Cytomap	1p35.3
	Type of Gene	protein-coding
	Description	sestrin-2hypoxia induced gene 95hypoxia-induced
	Modification date	20200313
	UniProtAcc	P58004

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SESN2	GO:0001932	regulation of protein phosphorylation	25040165
Hgene	SESN2	GO:0098869	cellular oxidant detoxification	26612684
Hgene	SESN2	GO:0098869	cellular oxidant detoxification	19113821

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
SESN2	(355.7 - 733]

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Translation Studies in PubMed

We searched PubMed using 'SESN2[title] AND translation [title] AND human.'

Gene	Title	PMID
SESN2	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KIRC	SESN2	-1.4159287345334	0.00355375517729543
COAD	SESN2	-6.51707583049217	2.62260437011719e-06

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
READ	SESN2	hsa-miR-152-3p	94	0.32611976630964	0.00350065136666227

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with SESN2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
UVM	IUPHAR	SESN2	ATP6V0B	0.811493387	6.98E-20

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
BRCA	SESN2	RRAGB	-1.27975621400166	0.000278783778460811
LIHC	SESN2	RRAGA	-2.96009581185639	0.000305812133392178
KIRP	SESN2	RRAGB	-3.58680487951826	0.000306400004774332
LUAD	SESN2	WDR59	-1.28501135742946	0.000427064479245173
KIRP	SESN2	RRAGC	2.06169733162019	0.000906126573681831
BRCA	SESN2	RHEB	-1.34423616302394	0.00103883851257192
HNSC	SESN2	RRAGA	-2.32133172052255	0.00712196445851987
CHOL	SESN2	RRAGB	-3.88357101572	0.0078125
CHOL	SESN2	WDR59	-1.44405884845641	0.0078125
UCEC	SESN2	TP53	2.03295038376694	0.015625
KICH	SESN2	RHEB	1.83191315229171	0.0236499309539795
UCEC	SESN2	RRAGB	-6.05482047820093	0.046875
BRCA	SESN2	RRAGA	-2.15295781334787	1.30187193146824e-07
LUAD	SESN2	WDR24	-1.74081882357912	1.40257798617898e-05
PRAD	SESN2	RRAGB	-3.1338604885693	1.87103930878711e-08
THCA	SESN2	MIOS	1.01353344032942	2.48217188234109e-07
BRCA	SESN2	WDR24	-1.76866802171037	2.69377755932838e-13
LIHC	SESN2	WDR59	-1.24255925939342	2.91676217374358e-05
PRAD	SESN2	RRAGA	-1.7630136395582	3.48680611380275e-05
LUSC	SESN2	WDR59	-1.87703221223	3.64325144746635e-05
KIRC	SESN2	TP53	-1.43050981150632	4.58942580328929e-09
PRAD	SESN2	RHEB	1.54870835586921	4.59461327401057e-05
THCA	SESN2	TP53	-1.81960143635647	6.18215597921662e-07
LUSC	SESN2	WDR24	-1.76500977282916	7.48588766065093e-05
COAD	SESN2	WDR24	-2.00075916625288	7.53998756408692e-06
HNSC	SESN2	MIOS	-1.49795072704533	8.09852713246075e-05
PRAD	SESN2	MTOR	2.45767376269894	8.16442831201447e-07

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with SESN2

PRDX1, SQSTM1, RBX1, KEAP1, VCP, MDM2, ULK1, RB1CC1, ATG13, SEC13, WDR5, WDR59, EGFR, DHX57, DEPDC5, WDR24, MIOS, NPRL3, NPRL2, SZT2, PLEKHA4, RNF186, nsp2, FASN, DDX58, EDEM1, GYPA, RBBP5, EP300,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
SESN2	chr1	28595709	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SESN2	chr1	28598229	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SESN2	chr1	28598287	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SESN2	chr1	28599898	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SESN2	chr1	28599952	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SESN2	chr1	28599961	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SESN2	chr1	28600024	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SESN2	chr1	28600027	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SESN2	chr1	28600574	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SESN2	chr1	28600607	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SESN2	chr1	28601407	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
SESN2	UCEC	chr1	28599128	28599128	G	A	Missense_Mutation	p.A192T	5
SESN2	LIHC	chr1	28598805	28598805	G	A	Missense_Mutation	p.R122H	4
SESN2	CESC	chr1	28599131	28599131	G	A	Missense_Mutation	p.E193K	4
SESN2	SKCM	chr1	28598868	28598868	C	T	Missense_Mutation	p.P143L	3
SESN2	SKCM	chr1	28607230	28607230	C	T	Missense_Mutation	p.H454Y	3
SESN2	LIHC	chr1	28599234	28599234	C	-	Frame_Shift_Del	p.A227fs	3
SESN2	PAAD	chr1	28601432	28601432	C	A	Missense_Mutation	p.L373I	3
SESN2	PAAD	chr1	28607282	28607282	C	T	Missense_Mutation	p.A471V	3
SESN2	BRCA	chr1	28598251	28598251	C	T	Nonsense_Mutation	p.R75*	3
SESN2	BRCA	chr1	28601371	28601371	C	G	Missense_Mutation	p.I352M	3
SESN2	CESC	chr1	28599131	28599131	G	A	Missense_Mutation		2
SESN2	ESCA	chr1	28601526	28601526	G	T	Missense_Mutation		2
SESN2	CESC	chr1	28595719	28595719	G	A	Missense_Mutation		2
SESN2	LGG	chr1	28598956	28598956	C	T	Silent	p.L172L	2
SESN2	UCEC	chr1	28599955	28599955	C	T	Silent	p.S279	2
SESN2	SKCM	chr1	28595741	28595741	C	A	Silent	p.A46A	2
SESN2	STAD	chr1	28598946	28598946	G	A	Missense_Mutation		2
SESN2	CESC	chr1	28598238	28598238	G	A	Silent		2
SESN2	LIHC	chr1	28595721	28595721	G	A	Missense_Mutation	p.G40S	2
SESN2	UCEC	chr1	28607232	28607232	C	T	Silent	p.H454	2
SESN2	STAD	chr1	28598946	28598946	G	A	Missense_Mutation	p.R169Q	2
SESN2	CESC	chr1	28601431	28601431	C	T	Silent		2
SESN2	LIHC	chr1	28598953	28598953	G	T	Missense_Mutation	p.W171C	2
SESN2	SKCM	chr1	28605652	28605652	G	A	Missense_Mutation	p.R419Q	2
SESN2	PAAD	chr1	28607282	28607282	C	T	Missense_Mutation		2
SESN2	STAD	chr1	28595728	28595728	G	A	Missense_Mutation	p.R42Q	2
SESN2	LGG	chr1	28598956	28598956	C	T	Silent		2
SESN2	LIHC	chr1	28599989	28599989	A	-	Frame_Shift_Del	p.K291fs	2
SESN2	SKCM	chr1	28599287	28599287	C	T	Missense_Mutation	p.P245S	2
SESN2	SKCM	chr1	28599288	28599288	C	T	Missense_Mutation	p.P245L	2
SESN2	LUAD	chr1	28601354	28601354	C	A	Missense_Mutation	p.H347N	2
SESN2	LIHC	chr1	28599950	28599950	A	G	Missense_Mutation		2
SESN2	SKCM	chr1	28607248	28607248	C	T	Silent	p.L460L	2
SESN2	LIHC	chr1	28598805	28598805	G	A	Missense_Mutation		2
SESN2	SKCM	chr1	28599183	28599183	T	G	Missense_Mutation	p.F210C	2
SESN2	PRAD	chr1	28598206	28598206	A	C	Missense_Mutation	p.S60R	2
SESN2	COAD	chr1	28586376	28586376	C	G	Silent	p.S6S	2
SESN2	LIHC	chr1	28595721	28595721	G	A	Missense_Mutation		2
SESN2	LIHC	chr1	28598953	28598953	G	T	Missense_Mutation		2
SESN2	SKCM	chr1	28605701	28605701	C	T	Silent	p.T435T	2
SESN2	ESCA	chr1	28598185	28598185	G	T	Missense_Mutation		1
SESN2	LUAD	chr1	28599220	28599220	A	T	Silent	p.A222A	1
SESN2	LUSC	chr1	28599167	28599167	C	T	Missense_Mutation	p.H205Y	1
SESN2	SKCM	chr1	28599254	28599254	C	T	Missense_Mutation	p.P234S	1
SESN2	HNSC	chr1	28598377	28598378	-	T	Frame_Shift_Ins	p.H117fs	1
SESN2	PRAD	chr1	28595713	28595713	C	T	Missense_Mutation	p.A37V	1
SESN2	UCEC	chr1	28607232	28607232	C	T	Silent	p.H454H	1
SESN2	COAD	chr1	28598336	28598336	C	T	Missense_Mutation	p.T103M	1
SESN2	LIHC	chr1	28598852	28598852	C	A	Missense_Mutation	p.Q138K	1
SESN2	LUAD	chr1	28598891	28598891	C	T	Missense_Mutation	p.R151W	1
SESN2	LUSC	chr1	28601391	28601391	G	T	Missense_Mutation	p.G359V	1
SESN2	STAD	chr1	28595728	28595728	G	A	Missense_Mutation		1
SESN2	PRAD	chr1	28599228	28599228	G	T	Missense_Mutation	p.S225I	1
SESN2	COAD	chr1	28599237	28599237	C	A	Missense_Mutation	p.P228H	1
SESN2	GBM	chr1	28598242	28598242	T	C	Missense_Mutation		1
SESN2	OV	chr1	28471771	28471771	C	T	Silent		1
SESN2	LGG	chr1	28599885	28599885	G	A	Missense_Mutation	p.R256H	1
SESN2	COAD	chr1	28599898	28599898	G	A	Silent	p.A260A	1
SESN2	SARC	chr1	28599870	28599870	G	T	Missense_Mutation		1
SESN2	SKCM	chr1	28599271	28599271	C	T	Silent	p.S239S	1
SESN2	GBM	chr1	28599274	28599274	C	A	Silent		1
SESN2	OV	chr1	28601440	28601440	C	T	Silent	p.Y375	1
SESN2	LGG	chr1	28599172	28599172	G	A	Silent	p.S206S	1
SESN2	COAD	chr1	28600553	28600553	G	A	Missense_Mutation	p.D302N	1
SESN2	SKCM	chr1	28600014	28600014	C	T	Missense_Mutation	p.P299L	1
SESN2	BLCA	chr1	28605706	28605706	G	A	Missense_Mutation		1
SESN2	HNSC	chr1	28598377	28598378	-	-	Frame_Shift_Ins		1
SESN2	COAD	chr1	28600589	28600589	T	A	Missense_Mutation	p.C314S	1
SESN2	SKCM	chr1	28595748	28595748	C	T	Missense_Mutation	p.P49S	1
SESN2	SKCM	chr1	28600013	28600013	C	T	Missense_Mutation	p.P299S	1
SESN2	BLCA	chr1	28605669	28605669	A	G	Missense_Mutation		1
SESN2	HNSC	chr1	28598309	28598309	G	C	Missense_Mutation		1
SESN2	PAAD	chr1	28595710	28595710	G	A	Missense_Mutation		1
SESN2	STAD	chr1	28598320	28598320	T	C	Missense_Mutation	p.Y98H	1
SESN2	CESC	chr1	28595719	28595719	G	A	Missense_Mutation	p.R39Q	1
SESN2	LGG	chr1	28599172	28599172	G	A	Silent		1
SESN2	COAD	chr1	28595715	28595715	C	T	Missense_Mutation	p.R38W	1
SESN2	LUAD	chr1	28598805	28598805	G	C	Missense_Mutation	p.R122P	1
SESN2	SKCM	chr1	28601482	28601482	C	T	Silent	p.L389L	1
SESN2	BLCA	chr1	28599209	28599209	G	A	Missense_Mutation		1
SESN2	HNSC	chr1	28598203	28598203	G	C	Missense_Mutation		1
SESN2	STAD	chr1	28598873	28598873	T	C	Missense_Mutation	p.W145R	1
SESN2	CESC	chr1	28598238	28598238	G	A	Silent	p.L70	1
SESN2	LGG	chr1	28599885	28599885	G	A	Missense_Mutation		1
SESN2	COAD	chr1	28599955	28599955	C	T	Silent	p.S279S	1
SESN2	LIHC	chr1	28598884	28598884	C	-	Frame_Shift_Del	p.G148fs	1
SESN2	SKCM	chr1	28599203	28599203	C	T	Missense_Mutation	p.L217F	1
SESN2	BLCA	chr1	28605706	28605706	G	A	Missense_Mutation	p.R437Q	1
SESN2	HNSC	chr1	28599144	28599144	C	T	Missense_Mutation		1
SESN2	STAD	chr1	28607245	28607245	C	T	Missense_Mutation	p.L459F	1
SESN2	CESC	chr1	28600017	28600017	C	G	Nonsense_Mutation	p.S300*	1
SESN2	ESCA	chr1	28598185	28598185	G	T	Missense_Mutation	p.V53F	1
SESN2	LIHC	chr1	28599123	28599123	C	-	Frame_Shift_Del	p.S190fs	1
SESN2	LUAD	chr1	28598184	28598184	G	T	Splice_Site		1
SESN2	SKCM	chr1	28600569	28600569	C	T	Missense_Mutation	p.S307F	1
SESN2	BLCA	chr1	28605669	28605669	A	G	Missense_Mutation	p.I425V	1
SESN2	HNSC	chr1	28598203	28598203	G	C	Missense_Mutation	p.E59Q	1
SESN2	PAAD	chr1	28595710	28595710	G	A	Missense_Mutation	p.R36Q	1
SESN2	THYM	chr1	28601489	28601489	G	A	Missense_Mutation	p.A392T	1
SESN2	CESC	chr1	28601431	28601431	C	T	Silent	p.S372	1
SESN2	ESCA	chr1	28599234	28599234	C	-	Frame_Shift_Del	p.Q229fs	1
SESN2	LIHC	chr1	28598196	28598196	G	-	Frame_Shift_Del	p.E56fs	1
SESN2	LUAD	chr1	28600590	28600590	G	A	Missense_Mutation	p.C314Y	1
SESN2	SKCM	chr1	28605653	28605653	G	A	Silent	p.R419R	1
SESN2	HNSC	chr1	28599144	28599144	C	T	Missense_Mutation	p.A197V	1
SESN2	ESCA	chr1	28601526	28601526	G	T	Missense_Mutation	p.R404I	1
SESN2	LUAD	chr1	28598184	28598184	G	T	Splice_Site	p.V53_splice	1
SESN2	SKCM	chr1	28599253	28599253	C	T	Silent	p.P233P	1
SESN2	HNSC	chr1	28598309	28598309	G	C	Missense_Mutation	p.W94S	1
SESN2	PRAD	chr1	28601484	28601484	G	A	Missense_Mutation	p.R390H	1
SESN2	UCEC	chr1	28601513	28601513	G	A	Missense_Mutation	p.V400I	1
SESN2	COAD	chr1	28598199	28598199	G	T	Silent	p.G57G	1
SESN2	LIHC	chr1	28598287	28598287	C	T	Missense_Mutation		1

Copy number variation (CNV) of SESN2
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across SESN2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
80834	LIHC	TCGA-ZS-A9CF-01A	PHACTR4	chr1	28696336	+	SESN2	chr1	28595694	+
80834	KIRC	TCGA-CZ-5453-01A	POMGNT1	chr1	46657770	-	SESN2	chr1	28607227	+
80834	N/A	AW300167	RRAGA	chr9	19050780	-	SESN2	chr1	28594630	-
80834	N/A	CN366113	SESN2	chr1	28608467	+	SESN2	chr1	28598892	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
HNSC	SESN2	0.000907382395775052	0.025
LUAD	SESN2	0.00121607166074498	0.033
KIRC	SESN2	0.0298977499330298	0.78
THYM	SESN2	0.0424797427618753	1
COAD	SESN2	0.0434775089225066	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	SESN2	0.000495889543483005	0.016
PAAD	SESN2	0.0288798567922198	0.9
SARC	SESN2	0.00362909252059392	0.12

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0009402	Colorectal Carcinoma	1	CTD_human
C0019193	Hepatitis, Toxic	1	CTD_human
C1262760	Hepatitis, Drug-Induced	1	CTD_human
C3658290	Drug-Induced Acute Liver Injury	1	CTD_human
C4277682	Chemical and Drug Induced Liver Injury	1	CTD_human
C4279912	Chemically-Induced Liver Toxicity	1	CTD_human