TranslFac Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Gene Summary

leaf

Translation studies in PubMed

leaf

Exon Skipping Events

leaf

Expression

leaf

Expression Regulation

leaf

Associated Genes

leaf

Protein 3D Structure

leaf

Protein-Protein Interaction

leaf

Mutations

leaf

Prognostic Analysis

leaf

Gender Association

leaf

Age Association

leaf

Related Drugs

leaf

Related Diseases

Translation Factor: EIF1AD (NCBI Gene ID:84285)


Gene Summary

check button Gene Summary
Gene InformationGene Name: EIF1AD
Gene ID: 84285
Gene Symbol

EIF1AD

Gene ID

84285

Gene Nameeukaryotic translation initiation factor 1A domain containing
SynonymsOBELIX|haponin
Cytomap

11q13.1

Type of Geneprotein-coding
Descriptionprobable RNA-binding protein EIF1ADeukaryotic translation initiation factor 1A domain-containing protein
Modification date20200313
UniProtAcc

Q8N9N8


check button Child GO biological process term(s) under GO:0006412
GO IDGO term
GO:0006417Regulation of translation
GO:0008135Translation factor activity, RNA binding
GO:0006413Translational initiation
GO:0006412Translation


check button Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Inferred gene age of translation factor.
GeneInferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
EIF1AD>1119.25


Top


Translation Studies in PubMed

check button We searched PubMed using 'EIF1AD[title] AND translation [title] AND human.'
GeneTitlePMID
EIF1AD..


Top


Exon Skipping Events

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.
all structure

check button Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ENSTExon skip start (DNA)Exon Skip end (DNA)ORF
ENST000003122346576682065766868In-frame
ENST000005264516576682065766868In-frame
ENST000005272496576682065766868In-frame
ENST000005299646576682065766868In-frame
ENST000005335446576682065766868In-frame
ENST0000031223465767773657679473UTR-3CDS
ENST0000052724965767773657679523UTR-3CDS
ENST0000052996465767773657678773UTR-3CDS
ENST0000053354465767773657679763UTR-3CDS

check button Exon skipping position in the amino acid sequence.
ENSTExon skip start (DNA)Exon Skip end (DNA)Len(transcript seq)Exon skip start (mRNA)Exon Skip end (mRNA)Len(amino acid seq)Exon skip start (AA)Exon Skip end (AA)
ENST000005299646576682065766868825450497165102117
ENST000005272496576682065766868906665712165102117
ENST000005335446576682065766868982667714165102117
ENST0000052645165766820657668682778515562165102117
ENST0000031223465766820657668682904641688165102117

check button Potentially (partially) lost protein functional features of UniProt.
UniProtAccExon skip start (AA)Exon Skip end (AA)Function feature start (AA)Function feature end (AA)Functional feature typeFunctional feature desc.
Q8N9N81021171165ChainID=PRO_0000314151;Note=Probable RNA-binding protein EIF1AD
Q8N9N81021171165ChainID=PRO_0000314151;Note=Probable RNA-binding protein EIF1AD
Q8N9N81021171165ChainID=PRO_0000314151;Note=Probable RNA-binding protein EIF1AD
Q8N9N81021171165ChainID=PRO_0000314151;Note=Probable RNA-binding protein EIF1AD
Q8N9N81021171165ChainID=PRO_0000314151;Note=Probable RNA-binding protein EIF1AD
Q8N9N8102117104110HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DGY
Q8N9N8102117104110HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DGY
Q8N9N8102117104110HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DGY
Q8N9N8102117104110HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DGY
Q8N9N8102117104110HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DGY


Top


Expression


check buttonGene expression level across TCGA pancancer
all structure

check buttonGene expression level across GTEx pantissue
all structure

check buttonExpression level of gene isoforms across TCGA pancancer
all structure

check buttonExpression level of gene isoforms across GTEx pantissue
all structure

check buttonCancer(tissue) type-specific expression level of Translation factor using z-score distriution
all structure

check buttonDifferential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)
all structure
Cancer typeTranslation factorFCadj.pval
LIHCEIF1AD-1.650122040053650.000117320704426747
CHOLEIF1AD-3.621902571705090.01171875
STADEIF1AD-3.238662522152415.4334755986929e-05
KIRCEIF1AD-1.778436678431246.13619476098216e-10


Top


Expression Regulation


check buttonTranslation factor expression regulation through miRNA binding
Cancer typeGenemiRNATargetScan binding score (Context++ score percentile)CoefficientPvalue
UCSEIF1ADhsa-miR-206930.4067669172932330.00201819928268806


check buttonTranslation factor expression regulation through methylation in the promoter of Translation factor
all structure
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a

check buttonTranslation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)
all structure
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a

check buttonTranslation factor expression regulation through copy number variation of Translation factor
all structure
Cancer typeGeneCoefficientPvalue
HNSCEIF1AD-0.1496371150.011457252
OVEIF1AD-0.1029290920.026175937
COADEIF1AD0.0299276440.02975498

Top


Associated Genes


check button Strongly correlated genes belong to cellular important gene groups with EIF1AD (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)
Cancer typeGene groupTranslation factorCorrelated geneCoefficientPvalue


Top


Protein structure


check button Protein 3D structure
Visit iCn3D.


Top


Protein-Protein Interaction


check button Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure

check buttonOverlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure
check button
* Edge colors based on TCGA cancer types.

check button* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))
all structure
Cancer typeTranslation factorInteracting protein coding geneFCadj.pval
LIHCEIF1ADRPSA-2.661818046259880.00010013220697745
BRCAEIF1ADRPS15A-1.394031743096990.000110797167056844
LUSCEIF1ADRPS21-3.866462958345540.000217448138016549
STADEIF1ADRPS231.850767606645760.000364991836249828
KICHEIF1ADNOB11.356767192775620.000631332397460937
COADEIF1ADRPS20-3.552148276604470.0010443925857544
KIRPEIF1ADRPS11-1.018615705651030.00105937570333481
LUADEIF1ADRPS21-2.063552090279840.00342681008979313
KICHEIF1ADRPS20-2.307572335617270.00612920522689819
CHOLEIF1ADRPSA-1.885012537119620.0078125
ESCAEIF1ADRPS21-3.394372190113660.009765625
STADEIF1ADRPS15A1.101409977860820.0148032568395138
THCAEIF1ADFAU1.185094504702620.0152379297688856
LUSCEIF1ADRPS231.467511698910470.0174932185880974
KIRPEIF1ADFAU-1.043550483532710.0309218638576567
COADEIF1ADRPS111.353075489982040.0312207043170929
BLCAEIF1ADRPS20-3.28694100150550.0360679626464844
COADEIF1ADRPS91.186120144022350.0381683111190796
BLCAEIF1ADRPS15A-3.679196907429660.0445594787597656
UCECEIF1ADRPS23-2.036581598140070.046875
PRADEIF1ADRPSA1.151835889908720.0476188245531179
KIRCEIF1ADFAU-2.501354258838011.33253564327251e-08
KIRPEIF1ADRPS20-1.445809213579441.60322524607182e-05
THCAEIF1ADRPS2-2.97496914227221.8399565126656e-05
KIRCEIF1ADRPS15A-4.142526239920162.15831756070263e-10
KIRCEIF1ADRPS2-3.316230583457192.17100738110179e-12
KIRCEIF1ADNOB1-1.762220583715772.17245182514006e-08
BRCAEIF1ADRPS91.93314775463492.31299392089389e-07
KIRPEIF1ADRPS15A-1.511451014173854.02145087718964e-06
KIRCEIF1ADRPS21-1.22226515129064.25761914751048e-08
KIRPEIF1ADRPS2-2.727880215667915.12227416038514e-08
LUADEIF1ADRPS2-2.889920984964686.51132046672323e-08
KIRCEIF1ADRPS9-1.326808164409876.53264115309597e-07
KIRCEIF1ADRPS20-2.623808247795697.86590430905899e-10
KICHEIF1ADRPS2-4.734263153074698.34465026855468e-07


check button Protein-protein interactors with this translation factor (BIOGRID-3.4.160)
PPI interactors with EIF1AD
STAT1, ELAVL1, MEOX2, SDCBP, ZBTB14, STX11, TBC1D5, SDCBP2, CEP55, GLYR1, BEND7, ZBTB8A, MOV10, NXF1, DPPA2, HBS1L, KRAS, PAX6, LNX1, MID2, PICK1, CEP76, AES, PBX4, MREG, RBM48, GAS8, RBAK, TNNI1, AP2M1, ENTHD2, ZNF558, GCSAML, ZNF280A, CCDC106, RASSF10, ZNF521, GTF2H4, PINX1, KDM8, ATG3, MAP4K5, CAMKV, POLD2, CARKD, MID1, DIP2B, GATA6, HEXIM1, HOXB9, ARRB2, CD3EAP, CSNK1G3, LRRC47, MGME1, CSNK1E, GRK6, PDCD2L, MPP6, CHEK1, RBPJ, GNB1L, IP6K1, PSMC3IP, TRMT61B, RNF138, TRMT1L, MND1, UTP6, DUS3L, ECT2, POLR1E, MCAT, KLHL42, WDR45B, AMPD2, DLG3, TBC1D23, ISL2, HNRNPLL, CASK, CTC1, OBFC1, SNX27, MTERF1, SCLY,


Top


Mutations


check button Clinically associated variants from ClinVar.
GeneChrPositionRefSeqVarSeqRefSeeqVarTypePathogenicDiseaseVarInfo


check button nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.
all structure


check button SNVs and Indels
GeneCancer typeChromosomeStartEndRefSeeqMutSeqMutation typeAAchange# samples
EIF1ADBRCAchr116576784865767848TCMissense_Mutationp.T5A3
EIF1ADSTADchr116576712265767122AGMissense_Mutationp.I74T2
EIF1ADSTADchr116576777665767776TCMissense_Mutationp.R29G2
EIF1ADKIRPchr116576711765767117CANonsense_Mutation2
EIF1ADLIHCchr116576685565766855AGMissense_Mutation2
EIF1ADSTADchr116576754865767548GAMissense_Mutation2
EIF1ADSTADchr116576754865767548GAMissense_Mutationp.R58C2
EIF1ADLUADchr116576711365767113CTMissense_Mutationp.G77E1
EIF1ADCHOLchr116576710365767103CTSilentp.V80V1
EIF1ADLUADchr116576611665766116TAMissense_Mutationp.Q151L1
EIF1ADCHOLchr116576710365767103CTSilent1
EIF1ADLUADchr116576682065766820CASplice_Site1
EIF1ADDLBCchr116576757865767578GAMissense_Mutationp.R48C1
EIF1ADLUSCchr116576758265767582CTSilentp.G46G1
EIF1ADHNSCchr116576619565766195GAMissense_Mutation1
EIF1ADLUSCchr116576703865767038CAMissense_Mutationp.W102_splice1
EIF1ADHNSCchr116576619565766195GAMissense_Mutationp.P125S1
EIF1ADLUSCchr116576685465766854GTMissense_Mutationp.S107Y1
EIF1ADPAADchr116576779465767794CAMissense_Mutation1
EIF1ADLGGchr116576612265766122CTMissense_Mutationp.R149H1
EIF1ADPRADchr116576761765767617CATranslation_Start_Site1
EIF1ADSKCMchr116576609965766099CTMissense_Mutationp.E157K1
EIF1ADLIHCchr116576708865767088CTSilentp.S85S1
EIF1ADLIHCchr116576779865767798G-Frame_Shift_Delp.P21fs1

check buttonCopy number variation (CNV) of EIF1AD
* Click on the image to open the original image in a new window.
all structure

check buttonFusion gene breakpoints (product of the structural variants (SVs)) across EIF1AD
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


check button Fusion genes with this translation factor from FusionGDB2.0.
FusionGDB2 IDDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
25620LIHCTCGA-DD-AADB-01AEIF1ADchr1165766821-CATSPER1chr1165784645-
25620N/ABF515226EIF1ADchr1165764215+EIF1ADchr1165765792-
72495STADTCGA-BR-7958EIF1ADchr1165769510-NECAP2chr116778332+


Top


Prognostic Analysis


check button Kaplan-Meier plots with logrank tests of overall survival (OS)
all structure
Cancer typeTranslation factorCoefficentHazard ratioWald test pvalLikelihool ratio pvalLogrank test pval# samples


Top


Translation factor and Gender


check button Differential gene expression between female and male. (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
TGCTEIF1AD0.0001591168029799660.0045
LAMLEIF1AD0.03842162005279881

Top


Translation factor and Age


check button Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
LUADEIF1AD0.0006359362049123170.021
KICHEIF1AD0.01568306823856020.47
LGGEIF1AD0.00627318920570830.2
UCECEIF1AD0.006793925646302360.21
HNSCEIF1AD0.02766251666180210.8

Top


Related Drugs


check button Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)
UniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top


Related Diseases


check button Diseases associated with this translation factor.
(DisGeNet 4.0)
Disease IDDisease Name# PubMedsDisease source
C0025202melanoma1CTD_human