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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: KBTBD8 (NCBI Gene ID:84541)

Gene Summary

Gene Summary

Gene Information	Gene Name: KBTBD8
	Gene ID: 84541
	Gene Symbol	KBTBD8
	Gene ID	84541
	Gene Name	kelch repeat and BTB domain containing 8
	Synonyms	TA-KRP\|TAKRP
	Cytomap	3p14.1
	Type of Gene	protein-coding
	Description	kelch repeat and BTB domain-containing protein 8T-cell activation kelch repeat proteinkelch repeat and BTB (POZ) domain containing 8
	Modification date	20200313
	UniProtAcc	Q8NFY9

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	KBTBD8	GO:0006513	protein monoubiquitination	26399832

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
KBTBD8	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'KBTBD8[title] AND translation [title] AND human.'

Gene	Title	PMID
KBTBD8	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000417314	67049404	67049615	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUAD	KBTBD8	-1.32707776466713	0.000130920842563376
LUSC	KBTBD8	-5.97558273500412	1.17196777803049e-08

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
UCEC	KBTBD8	hsa-miR-200b-3p	78	-0.401680672268908	0.0192227243766155
UCEC	KBTBD8	hsa-miR-429	78	-0.346676852559205	0.0452029292903808

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
CESC	KBTBD8	3	2	0.0175775427817325	0.662235064935065	0.374554365079365	0.819989207957264	0.427934329171026

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
GBM	KBTBD8	-0.112686466	0.004306704
UCS	KBTBD8	-0.024495222	0.044302848
THYM	KBTBD8	0.074108499	0.047261917

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with KBTBD8 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	IUPHAR	KBTBD8	CYSLTR1	0.81240717	1.24E-11
CHOL	TF	KBTBD8	ETS1	0.805052347	2.63E-11
CHOL	TSG	KBTBD8	LRMP	0.818159476	6.77E-12
LUAD	CGC	KBTBD8	PTPRC	0.804027172	1.04E-131
LUAD	CGC	KBTBD8	BTK	0.81631325	6.14E-139
LUAD	IUPHAR	KBTBD8	PTPRC	0.804027172	1.04E-131
LUAD	IUPHAR	KBTBD8	BTK	0.81631325	6.14E-139
LUAD	Kinase	KBTBD8	BTK	0.81631325	6.14E-139
LUAD	TSG	KBTBD8	PTPRC	0.804027172	1.04E-131
LUAD	TSG	KBTBD8	BTK	0.81631325	6.14E-139
PAAD	Cell metabolism gene	KBTBD8	PIK3R5	0.802784962	1.67E-42
PAAD	CGC	KBTBD8	WAS	0.804478289	8.29E-43
PAAD	CGC	KBTBD8	CCR7	0.830260084	8.04E-48
PAAD	CGC	KBTBD8	BTK	0.835688448	5.51E-49
PAAD	CGC	KBTBD8	ITK	0.843221639	1.13E-50
PAAD	CGC	KBTBD8	P2RY8	0.846381362	2.09E-51
PAAD	CGC	KBTBD8	BCL2	0.851115527	1.54E-52
PAAD	CGC	KBTBD8	FLI1	0.86247747	2.00E-55
PAAD	CGC	KBTBD8	PRKCB	0.869654002	2.20E-57
PAAD	CGC	KBTBD8	PTPRC	0.876207881	2.82E-59
PAAD	CGC	KBTBD8	IKZF1	0.890402335	8.96E-64
PAAD	Epifactor	KBTBD8	PRKCB	0.869654002	2.20E-57
PAAD	Epifactor	KBTBD8	IKZF1	0.890402335	8.96E-64
PAAD	IUPHAR	KBTBD8	KCNA3	0.800545414	4.15E-42
PAAD	IUPHAR	KBTBD8	GPR171	0.800716757	3.87E-42
PAAD	IUPHAR	KBTBD8	PIK3R5	0.802784962	1.67E-42
PAAD	IUPHAR	KBTBD8	TIGIT	0.806995519	2.90E-43
PAAD	IUPHAR	KBTBD8	CSF2RB	0.812435047	2.85E-44
PAAD	IUPHAR	KBTBD8	MAP4K1	0.81255843	2.70E-44
PAAD	IUPHAR	KBTBD8	NLRC3	0.812592688	2.66E-44
PAAD	IUPHAR	KBTBD8	GPR174	0.812656472	2.59E-44
PAAD	IUPHAR	KBTBD8	PYHIN1	0.814605384	1.10E-44
PAAD	IUPHAR	KBTBD8	GPR65	0.815605998	7.10E-45
PAAD	IUPHAR	KBTBD8	GPR18	0.815639277	7.00E-45
PAAD	IUPHAR	KBTBD8	CD37	0.816627047	4.52E-45
PAAD	IUPHAR	KBTBD8	SLC9A9	0.820257768	8.82E-46
PAAD	IUPHAR	KBTBD8	P2RY10	0.823344704	2.13E-46
PAAD	IUPHAR	KBTBD8	IL10RA	0.825236274	8.83E-47
PAAD	IUPHAR	KBTBD8	ITGA4	0.825372017	8.29E-47
PAAD	IUPHAR	KBTBD8	TLR10	0.826316247	5.31E-47
PAAD	IUPHAR	KBTBD8	ITGAL	0.827525938	2.99E-47
PAAD	IUPHAR	KBTBD8	CCR7	0.830260084	8.04E-48
PAAD	IUPHAR	KBTBD8	CD1D	0.831867665	3.67E-48
PAAD	IUPHAR	KBTBD8	BTK	0.835688448	5.51E-49
PAAD	IUPHAR	KBTBD8	ITK	0.843221639	1.13E-50
PAAD	IUPHAR	KBTBD8	P2RY8	0.846381362	2.09E-51
PAAD	IUPHAR	KBTBD8	BCL2	0.851115527	1.54E-52
PAAD	IUPHAR	KBTBD8	PRKCB	0.869654002	2.20E-57
PAAD	IUPHAR	KBTBD8	PTPRC	0.876207881	2.82E-59
PAAD	Kinase	KBTBD8	MAP4K1	0.81255843	2.70E-44
PAAD	Kinase	KBTBD8	BTK	0.835688448	5.51E-49
PAAD	Kinase	KBTBD8	ITK	0.843221639	1.13E-50
PAAD	Kinase	KBTBD8	PRKCB	0.869654002	2.20E-57
PAAD	TF	KBTBD8	ZNF831	0.806814957	3.13E-43
PAAD	TF	KBTBD8	POU2F2	0.813634928	1.69E-44
PAAD	TF	KBTBD8	FLI1	0.86247747	2.00E-55
PAAD	TF	KBTBD8	IKZF1	0.890402335	8.96E-64
PAAD	TSG	KBTBD8	RASSF2	0.806414324	3.70E-43
PAAD	TSG	KBTBD8	MAP4K1	0.81255843	2.70E-44
PAAD	TSG	KBTBD8	PYHIN1	0.814605384	1.10E-44
PAAD	TSG	KBTBD8	BTK	0.835688448	5.51E-49
PAAD	TSG	KBTBD8	PRKCB	0.869654002	2.20E-57
PAAD	TSG	KBTBD8	PTPRC	0.876207881	2.82E-59
PAAD	TSG	KBTBD8	IKZF1	0.890402335	8.96E-64
THCA	CGC	KBTBD8	PTPRC	0.801045143	3.88E-129
THCA	IUPHAR	KBTBD8	PTPRC	0.801045143	3.88E-129
THCA	TSG	KBTBD8	PTPRC	0.801045143	3.88E-129

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
COAD	KBTBD8	SPOPL	-1.08694266344672	0.00144392251968384
KIRP	KBTBD8	KLHL9	-1.1806241061267	0.00192895717918873
CHOL	KBTBD8	KLHL7	-1.51968283199004	0.00390625
LUSC	KBTBD8	SPOPL	-1.881897040654	0.00704157337736851
UCEC	KBTBD8	KLHL9	-2.66524658489551	0.015625
KIRC	KBTBD8	SPOP	-1.19329067564055	0.0174752890340146
BLCA	KBTBD8	KLHL9	1.98312234345761	0.0180816650390625
HNSC	KBTBD8	KLHL9	1.71475029854106	0.0291841810949336
READ	KBTBD8	SPOPL	-1.1014360894969	0.03125
THCA	KBTBD8	GAN	1.00056846055185	1.13795592860251e-05
LUAD	KBTBD8	SPOP	-1.89167312115157	1.6717782354243e-05
BRCA	KBTBD8	LZTR1	1.16270076403906	2.17904123402791e-05
PRAD	KBTBD8	KLHL13	-2.07372457351337	2.43318552922527e-08
KIRC	KBTBD8	KLHL13	-1.44010538276674	2.47133141387833e-13
KIRC	KBTBD8	LZTR1	-2.04082963143863	3.870655931333e-08
BRCA	KBTBD8	GAN	-1.67614794311118	4.18481835375004e-05
HNSC	KBTBD8	LZTR1	-2.05908861693602	4.59484322107785e-05
THCA	KBTBD8	KLHL9	-1.75204504846792	6.25847760426763e-06
BRCA	KBTBD8	RBX1	-2.04987881543868	6.72979683550832e-13

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with KBTBD8

CUL3, TCOF1, NOLC1, ARRB1, ARRB2, PKN1, POLR1A, GAN, KBTBD7, KLHL29, ZNF692, AGO2, KBTBD8, FBXL17, MOG, SOCS7, AGO4, CD6, BRD4,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
KBTBD8	UCEC	chr3	67053841	67053841	G	T	Missense_Mutation	p.Q124H	4
KBTBD8	BRCA	chr3	67053690	67053690	C	T	Missense_Mutation	p.S74L	3
KBTBD8	BRCA	chr3	67054333	67054333	G	A	Silent	p.V288	3
KBTBD8	BRCA	chr3	67058478	67058480	ATC	-	In_Frame_Del	p.H467in_frame_del	3
KBTBD8	PAAD	chr3	67058487	67058487	G	A	Missense_Mutation	p.R469H	3
KBTBD8	LIHC	chr3	67054129	67054129	A	T	Missense_Mutation		3
KBTBD8	LIHC	chr3	67053654	67053654	A	-	Frame_Shift_Del	p.Q62fs	3
KBTBD8	UCEC	chr3	67054474	67054474	G	A	Nonsense_Mutation	p.W335*	2
KBTBD8	STAD	chr3	67054650	67054650	G	A	Missense_Mutation	p.C420Y	2
KBTBD8	LIHC	chr3	67054509	67054509	A	T	Missense_Mutation		2
KBTBD8	SKCM	chr3	67054691	67054691	C	T	Missense_Mutation	p.H408Y	2
KBTBD8	UCEC	chr3	67054615	67054615	A	C	Silent	p.L382	2
KBTBD8	STAD	chr3	67053771	67053771	C	T	Missense_Mutation	p.A127V	2
KBTBD8	SKCM	chr3	67054151	67054151	C	T	Missense_Mutation	p.P228S	2
KBTBD8	SKCM	chr3	67054151	67054151	C	T	Missense_Mutation	p.P254S	2
KBTBD8	UCEC	chr3	67054645	67054645	G	T	Missense_Mutation	p.E392D	2
KBTBD8	SKCM	chr3	67054070	67054070	G	A	Missense_Mutation	p.E201K	2
KBTBD8	UCEC	chr3	67058507	67058507	T	C	Missense_Mutation	p.Y476H	2
KBTBD8	STAD	chr3	67058751	67058751	G	A	Missense_Mutation	p.R583Q	2
KBTBD8	UCEC	chr3	67049548	67049548	G	T	Nonsense_Mutation	p.E28*	2
KBTBD8	SKCM	chr3	67053896	67053896	G	A	Missense_Mutation	p.D143N	2
KBTBD8	UCEC	chr3	67058664	67058664	G	T	Missense_Mutation	p.R528I	2
KBTBD8	STAD	chr3	67058677	67058677	T	A	Silent	p.L558L	2
KBTBD8	UCEC	chr3	67053657	67053657	A	C	Missense_Mutation	p.K63T	2
KBTBD8	SKCM	chr3	67053666	67053666	G	A	Missense_Mutation	p.R66Q	2
KBTBD8	PAAD	chr3	67054530	67054530	G	T	Missense_Mutation		2
KBTBD8	UCEC	chr3	67053666	67053666	G	T	Missense_Mutation	p.R66L	2
KBTBD8	SKCM	chr3	67058534	67058534	C	T	Missense_Mutation	p.R485C	2
KBTBD8	CESC	chr3	67054649	67054649	T	C	Missense_Mutation		2
KBTBD8	LGG	chr3	67054104	67054104	A	G	Missense_Mutation		2
KBTBD8	LIHC	chr3	67054129	67054129	A	T	Missense_Mutation	p.E220D	2
KBTBD8	PAAD	chr3	67058487	67058487	G	A	Missense_Mutation		2
KBTBD8	SARC	chr3	67049586	67049586	C	A	Missense_Mutation		2
KBTBD8	SKCM	chr3	67053899	67053899	C	T	Nonsense_Mutation	p.R144*	2
KBTBD8	LIHC	chr3	67049479	67049479	C	T	Missense_Mutation		2
KBTBD8	PAAD	chr3	67058487	67058487	G	A	Missense_Mutation	p.R495H	2
KBTBD8	UCEC	chr3	67053970	67053970	A	C	Missense_Mutation	p.K167N	2
KBTBD8	STAD	chr3	67049548	67049548	G	A	Missense_Mutation		2
KBTBD8	PAAD	chr3	67054530	67054530	G	T	Missense_Mutation	p.R380I	2
KBTBD8	SKCM	chr3	67058673	67058673	C	T	Missense_Mutation	p.S531F	2
KBTBD8	UCEC	chr3	67054001	67054001	G	A	Missense_Mutation	p.D178N	2
KBTBD8	THCA	chr3	67058637	67058637	T	C	Missense_Mutation	p.V519A	2
KBTBD8	UCEC	chr3	67054146	67054146	A	C	Missense_Mutation	p.K226T	2
KBTBD8	STAD	chr3	67049611	67049611	T	C	Missense_Mutation	p.F75L	2
KBTBD8	CHOL	chr3	67054577	67054577	G	A	Missense_Mutation		2
KBTBD8	LUAD	chr3	67054667	67054667	G	C	Missense_Mutation	p.A400P	1
KBTBD8	SKCM	chr3	67058388	67058388	G	A	Missense_Mutation	p.G462D	1
KBTBD8	SKCM	chr3	67054126	67054126	G	A	Missense_Mutation	p.M219I	1
KBTBD8	BLCA	chr3	67058729	67058729	G	A	Missense_Mutation	p.D550N	1
KBTBD8	KIRC	chr3	67058722	67058722	G	C	Missense_Mutation	p.E547D	1
KBTBD8	LUSC	chr3	67054263	67054263	T	G	Missense_Mutation	p.F291C	1
KBTBD8	SKCM	chr3	67054066	67054066	G	A	Silent	p.Q225Q	1
KBTBD8	CHOL	chr3	67054577	67054577	G	A	Missense_Mutation	p.G370R	1
KBTBD8	SKCM	chr3	67054583	67054583	C	T	Missense_Mutation	p.R372C	1
KBTBD8	THYM	chr3	67054731	67054731	A	G	Missense_Mutation	p.Q447R	1
KBTBD8	HNSC	chr3	67058726	67058726	C	A	Missense_Mutation	p.P549T	1
KBTBD8	PCPG	chr3	67054375	67054375	G	T	Silent		1
KBTBD8	LUAD	chr3	67053770	67053770	G	T	Missense_Mutation	p.A101S	1
KBTBD8	SKCM	chr3	67054070	67054070	G	A	Missense_Mutation	p.E227K	1
KBTBD8	SKCM	chr3	67054579	67054579	A	C	Silent	p.G370G	1
KBTBD8	BLCA	chr3	67054357	67054357	T	C	Silent	p.N322N	1
KBTBD8	KIRC	chr3	67054477	67054477	G	T	Missense_Mutation	p.M336I	1
KBTBD8	MESO	chr3	67054039	67054039	C	A	Missense_Mutation		1
KBTBD8	SKCM	chr3	67053683	67053683	G	A	Missense_Mutation	p.A98T	1
KBTBD8	COAD	chr3	67049465	67049465	C	T	Missense_Mutation	p.A26V	1
KBTBD8	LIHC	chr3	67049555	67049555	A	G	Missense_Mutation	p.D56G	1
KBTBD8	UCEC	chr3	67058507	67058507	T	C	Missense_Mutation	p.Y502H	1
KBTBD8	HNSC	chr3	67054415	67054415	G	C	Missense_Mutation	p.G316R	1
KBTBD8	PCPG	chr3	67054375	67054375	G	T	Silent	p.G328G	1
KBTBD8	SKCM	chr3	67053691	67053691	G	A	Silent	p.S74S	1
KBTBD8	LUAD	chr3	67054705	67054705	G	T	Missense_Mutation	p.E412D	1
KBTBD8	SKCM	chr3	67058676	67058676	T	C	Missense_Mutation	p.L532P	1
KBTBD8	BLCA	chr3	67049613	67049613	C	T	Silent	p.F75F	1
KBTBD8	KIRP	chr3	67053891	67053891	T	C	Missense_Mutation	p.L167P	1
KBTBD8	COAD	chr3	67054144	67054144	G	T	Missense_Mutation	p.E251D	1
KBTBD8	LIHC	chr3	67049479	67049479	C	T	Missense_Mutation	p.H31Y	1
KBTBD8	OV	chr3	67054290	67054290	A	G	Missense_Mutation	p.K300R	1
KBTBD8	SKCM	chr3	67053896	67053896	G	A	Missense_Mutation	p.D169N	1
KBTBD8	STAD	chr3	67054660	67054663	TGTT	-	Frame_Shift_Del	p.423_424del	1
KBTBD8	PCPG	chr3	67054375	67054375	G	T	Silent	p.G302G	1
KBTBD8	UCEC	chr3	67054684	67054685	-	T	Frame_Shift_Ins	p.M431fs	1
KBTBD8	BLCA	chr3	67053835	67053835	C	A	Missense_Mutation		1
KBTBD8	HNSC	chr3	67058494	67058494	T	C	Silent	p.F471F	1
KBTBD8	LUAD	chr3	67053805	67053805	A	G	Silent	p.Q112Q	1
KBTBD8	SKCM	chr3	67058398	67058398	C	T	Silent	p.T465T	1
KBTBD8	SKCM	chr3	67053683	67053683	G	A	Missense_Mutation	p.A72T	1
KBTBD8	LGG	chr3	67054104	67054104	A	G	Missense_Mutation	p.K238R	1
KBTBD8	COAD	chr3	67054513	67054513	A	C	Silent	p.P374P	1
KBTBD8	LIHC	chr3	67054129	67054129	A	T	Missense_Mutation	p.E246D	1
KBTBD8	OV	chr3	67137261	67137261	G	A	Missense_Mutation	p.A368T	1
KBTBD8	SKCM	chr3	67058534	67058534	C	T	Missense_Mutation	p.R511C	1
KBTBD8	READ	chr3	67053843	67053843	A	C	Missense_Mutation	p.N151T	1
KBTBD8	SKCM	chr3	67058619	67058619	G	A	Missense_Mutation	p.R513Q	1
KBTBD8	BLCA	chr3	67054357	67054357	T	C	Silent		1
KBTBD8	HNSC	chr3	67049505	67049505	C	G	Silent	p.L13L	1
KBTBD8	LUAD	chr3	67053653	67053653	C	G	Missense_Mutation	p.Q62E	1
KBTBD8	SKCM	chr3	67054484	67054484	C	T	Missense_Mutation	p.H365Y	1
KBTBD8	LGG	chr3	67058751	67058751	G	A	Missense_Mutation	p.R557Q	1
KBTBD8	ESCA	chr3	67058470	67058470	C	T	Silent	p.T463T	1
KBTBD8	LIHC	chr3	67054509	67054509	A	T	Missense_Mutation	p.K373I	1
KBTBD8	OV	chr3	67058594	67058594	C	G	Missense_Mutation	p.Q505E	1
KBTBD8	SKCM	chr3	67054506	67054506	C	T	Missense_Mutation	p.S372F	1
KBTBD8	LIHC	chr3	67053851	67053851	G	-	Frame_Shift_Del	p.G128fs	1
KBTBD8	READ	chr3	67054634	67054634	G	A	Missense_Mutation	p.D415N	1
KBTBD8	SKCM	chr3	67058398	67058398	C	T	Silent	p.T439T	1
KBTBD8	BLCA	chr3	67049613	67049613	C	T	Silent		1
KBTBD8	HNSC	chr3	67054415	67054415	G	C	Missense_Mutation	p.G342R	1
KBTBD8	LUAD	chr3	67054223	67054223	C	T	Nonsense_Mutation	p.Q252*	1
KBTBD8	SKCM	chr3	67058642	67058642	G	A	Missense_Mutation	p.E547K	1
KBTBD8	LGG	chr3	67054104	67054104	A	G	Missense_Mutation	p.K212R	1
KBTBD8	GBM	chr3	67054666	67054666	C	T	Silent	p.C425C	1
KBTBD8	LIHC	chr3	67049479	67049479	C	T	Missense_Mutation	p.H5Y	1
KBTBD8	SKCM	chr3	67054579	67054579	A	C	Silent	p.G396G	1
KBTBD8	STAD	chr3	67049548	67049548	G	A	Missense_Mutation	p.E28K	1
KBTBD8	LIHC	chr3	67053904	67053904	A	-	Frame_Shift_Del	p.S145fs	1
KBTBD8	SARC	chr3	67053755	67053755	G	T	Missense_Mutation		1
KBTBD8	SKCM	chr3	67054484	67054484	C	T	Missense_Mutation	p.H339Y	1
KBTBD8	BLCA	chr3	67054363	67054363	G	A	Silent		1
KBTBD8	KIRC	chr3	67054477	67054477	G	T	Missense_Mutation	p.M362I	1
KBTBD8	LUAD	chr3	67058585	67058585	G	T	Missense_Mutation	p.V502L	1
KBTBD8	SKCM	chr3	67054583	67054583	C	T	Missense_Mutation	p.R398C	1
KBTBD8	STAD	chr3	67054660	67054663	TGTT	-	Frame_Shift_Del	p.T423fs	1
KBTBD8	HNSC	chr3	67054415	67054415	G	C	Missense_Mutation		1
KBTBD8	SKCM	chr3	67053665	67053665	C	T	Nonsense_Mutation	p.R92X	1
KBTBD8	LIHC	chr3	67049522	67049522	A	-	Frame_Shift_Del	p.E19fs	1
KBTBD8	BLCA	chr3	67058729	67058729	G	A	Missense_Mutation		1
KBTBD8	KIRC	chr3	67049417	67049417	C	G	Missense_Mutation	p.S10C	1
KBTBD8	LUAD	chr3	67053973	67053973	C	A	Missense_Mutation	p.D168E	1
KBTBD8	SKCM	chr3	67058673	67058673	C	T	Missense_Mutation	p.S557F	1
KBTBD8	SKCM	chr3	67058562	67058562	C	T	Missense_Mutation	p.S494F	1
KBTBD8	CESC	chr3	67058535	67058535	G	T	Missense_Mutation		1
KBTBD8	THCA	chr3	67058637	67058637	T	C	Missense_Mutation		1
KBTBD8	HNSC	chr3	67058534	67058534	C	A	Missense_Mutation		1
KBTBD8	LIHC	chr3	67054509	67054509	A	T	Missense_Mutation	p.K347I	1
KBTBD8	SKCM	chr3	67054126	67054126	G	A	Missense_Mutation	p.M245I	1
KBTBD8	LIHC	chr3	67053920	67053920	A	-	Frame_Shift_Del	p.K152fs	1
KBTBD8	SARC	chr3	67049586	67049586	C	A	Missense_Mutation	p.N40K	1
KBTBD8	SKCM	chr3	67058388	67058388	G	A	Missense_Mutation	p.G436D	1
KBTBD8	BLCA	chr3	67053835	67053835	C	A	Missense_Mutation	p.D122E	1
KBTBD8	KIRC	chr3	67049444	67049444	C	G	Missense_Mutation	p.S19C	1
KBTBD8	LUAD	chr3	67054205	67054205	A	T	Missense_Mutation	p.N246Y	1
KBTBD8	SKCM	chr3	67053691	67053691	G	A	Silent	p.S100S	1
KBTBD8	CESC	chr3	67048774	67048774	C	G	Missense_Mutation		1
KBTBD8	LIHC	chr3	67058640	67058640	A	G	Missense_Mutation		1
KBTBD8	THCA	chr3	67058637	67058637	T	C	Missense_Mutation	p.V545A	1
KBTBD8	HNSC	chr3	67053926	67053926	T	C	Missense_Mutation		1
KBTBD8	LIHC	chr3	67053919	67053920	-	A	Frame_Shift_Ins	p.RK150fs	1
KBTBD8	SKCM	chr3	67053665	67053665	C	T	Nonsense_Mutation	p.R66*	1
KBTBD8	LUAD	chr3	67053833	67053833	G	T	Missense_Mutation	p.D122Y	1
KBTBD8	SARC	chr3	67049586	67049586	C	A	Missense_Mutation	p.N66K	1
KBTBD8	BLCA	chr3	67054357	67054357	T	C	Silent	p.N296N	1
KBTBD8	KIRC	chr3	67049590	67049590	C	G	Missense_Mutation	p.L68V	1
KBTBD8	LUAD	chr3	67054223	67054223	C	T	Nonsense_Mutation	p.Q278*	1
KBTBD8	SKCM	chr3	67053899	67053899	C	T	Nonsense_Mutation	p.R170X	1
KBTBD8	STAD	chr3	67049548	67049548	G	A	Missense_Mutation	p.E54K	1
KBTBD8	CESC	chr3	67048774	67048774	C	G	RNA	NULL	1
KBTBD8	LIHC	chr3	67054718	67054718	A	G	Missense_Mutation		1
KBTBD8	SKCM	chr3	67058642	67058642	G	A	Missense_Mutation	p.E521K	1
KBTBD8	HNSC	chr3	67058494	67058494	T	C	Silent		1
KBTBD8	LIHC	chr3	67054005	67054006	-	A	Frame_Shift_Ins	p.*179fs	1
KBTBD8	SKCM	chr3	67054142	67054142	G	A	Missense_Mutation	p.E225K	1
KBTBD8	LUAD	chr3	67054199	67054199	C	T	Missense_Mutation	p.P244S	1
KBTBD8	SKCM	chr3	67058562	67058562	C	T	Missense_Mutation	p.S520F	1
KBTBD8	SKCM	chr3	67054506	67054506	C	T	Missense_Mutation	p.S346F	1
KBTBD8	BLCA	chr3	67049613	67049613	C	T	Silent	p.F49F	1
KBTBD8	KIRC	chr3	67058722	67058722	G	C	Missense_Mutation	p.E573D	1
KBTBD8	LUAD	chr3	67058585	67058585	G	T	Missense_Mutation	p.V528L	1
KBTBD8	SKCM	chr3	67053841	67053841	G	A	Silent	p.Q150Q	1
KBTBD8	SKCM	chr3	67054066	67054066	G	A	Silent	p.Q199Q	1
KBTBD8	THYM	chr3	67049505	67049505	C	A	Silent		1
KBTBD8	HNSC	chr3	67058726	67058726	C	A	Missense_Mutation		1
KBTBD8	PAAD	chr3	67054530	67054530	G	T	Missense_Mutation	p.R354I	1
KBTBD8	SKCM	chr3	67053841	67053841	G	A	Silent	p.Q124Q	1

Copy number variation (CNV) of KBTBD8
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across KBTBD8
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
59802	N/A	BF931598	NOVA1	chr14	27018917	+	KBTBD8	chr3	67053400	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
HNSC	KBTBD8	0.000134778095658695	0.0038
BRCA	KBTBD8	0.00150724115546615	0.041
TGCT	KBTBD8	0.0015508010189408	0.041
LGG	KBTBD8	0.00459418953773739	0.11
PAAD	KBTBD8	0.00573297959085462	0.14
LUAD	KBTBD8	0.00629055248223642	0.14
LIHC	KBTBD8	0.0167422389835492	0.37
THCA	KBTBD8	0.0241501141310638	0.51
MESO	KBTBD8	0.0243538881463218	0.51
LUSC	KBTBD8	0.040329747147875	0.77

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LAML	KBTBD8	0.0095951043458069	0.32
BRCA	KBTBD8	0.0112377513000056	0.36
PRAD	KBTBD8	0.0298020084371362	0.89
SKCM	KBTBD8	0.0459044546585856	1
ESCA	KBTBD8	0.0216738090895441	0.67

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source