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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MRPL43 (NCBI Gene ID:84545)

Gene Summary

Gene Summary

Gene Information	Gene Name: MRPL43
	Gene ID: 84545
	Gene Symbol	MRPL43
	Gene ID	84545
	Gene Name	mitochondrial ribosomal protein L43
	Synonyms	L43mt\|MRP-L43\|bMRP36a
	Cytomap	10q24.31
	Type of Gene	protein-coding
	Description	39S ribosomal protein L43, mitochondrialmitochondrial large ribosomal subunit protein mL43mitochondrial ribosomal protein bMRP36a
	Modification date	20200320
	UniProtAcc	Q8N983

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'MRPL43[title] AND translation [title] AND human.'

Gene	Title	PMID
MRPL43	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000318325	102746505	102746732	Frame-shift
ENST00000318325	102746846	102746953	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KICH	MRPL43	-2.18179102009894	0.00963503122329712

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
THYM	MRPL43	hsa-miR-193b-3p	85	-0.316762185183238	0.0051820897248208

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
BRCA	MRPL43	2	1	0.0241249952719395	0.253348146555842	0.186544848484849	0.200232333575248	-0.0679110651583909
THCA	MRPL43	2	1	0.0276654800306328	0.267568494208494	0.192442016806723	-0.719023235510525	-0.267690209543229

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
BRCA	MRPL43	-0.092546902	0.006193768

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MRPL43 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	MRPL43	FBXW4	0.802403939	3.41E-11
GBM	Cell metabolism gene	MRPL43	SUCLG1	0.819909572	4.92E-43
GBM	TF	MRPL43	ZNF32	0.859409085	2.11E-51
KICH	Cell metabolism gene	MRPL43	UROS	0.818438756	3.92E-23
KICH	TF	MRPL43	ZNF511	0.805314491	6.45E-22
THCA	Cell metabolism gene	MRPL43	UROD	0.800034091	1.41E-128
THCA	Cell metabolism gene	MRPL43	POLR2I	0.801929419	1.25E-129
THCA	Cell metabolism gene	MRPL43	DPM3	0.82427664	6.23E-143
THYM	Cell metabolism gene	MRPL43	EXOSC4	0.801922879	1.29E-28
THYM	Cell metabolism gene	MRPL43	APRT	0.80264615	1.06E-28
THYM	Cell metabolism gene	MRPL43	MTX1	0.81084808	1.08E-29
THYM	Cell metabolism gene	MRPL43	SNRPD2	0.813222097	5.45E-30
THYM	Cell metabolism gene	MRPL43	TIMM50	0.813599698	4.88E-30
THYM	Cell metabolism gene	MRPL43	ACOT8	0.81931135	9.05E-31
THYM	Cell metabolism gene	MRPL43	TIMM13	0.821611767	4.51E-31
THYM	Cell metabolism gene	MRPL43	TIMM8B	0.827746345	6.71E-32
THYM	Cell metabolism gene	MRPL43	EXOSC1	0.828944537	4.59E-32
THYM	Cell metabolism gene	MRPL43	PSMC3	0.829158019	4.29E-32
THYM	Cell metabolism gene	MRPL43	POLR2I	0.830579719	2.71E-32
THYM	Cell metabolism gene	MRPL43	ITPA	0.833778873	9.57E-33
THYM	CGC	MRPL43	MGMT	0.805821592	4.42E-29
THYM	Epifactor	MRPL43	EXOSC4	0.801922879	1.29E-28
THYM	Epifactor	MRPL43	PPP4C	0.8020254	1.25E-28
THYM	Epifactor	MRPL43	SIRT6	0.811132672	9.93E-30
THYM	Epifactor	MRPL43	PRPF31	0.811559812	8.79E-30
THYM	Epifactor	MRPL43	TAF10	0.812364076	6.98E-30
THYM	Epifactor	MRPL43	RUVBL2	0.826084017	1.13E-31
THYM	Epifactor	MRPL43	EXOSC1	0.828944537	4.59E-32
THYM	IUPHAR	MRPL43	SIRT6	0.811132672	9.93E-30
THYM	TF	MRPL43	ZNF428	0.810259925	1.27E-29
THYM	TF	MRPL43	ZNF787	0.812871671	6.03E-30
THYM	TF	MRPL43	ZNF511	0.852960954	1.11E-35
THYM	TSG	MRPL43	SIRT6	0.811132672	9.93E-30
THYM	TSG	MRPL43	PARK7	0.834804166	6.82E-33
UCS	Cell metabolism gene	MRPL43	EXOSC4	0.801922879	1.29E-28
UCS	Cell metabolism gene	MRPL43	APRT	0.80264615	1.06E-28
UCS	Cell metabolism gene	MRPL43	MTX1	0.81084808	1.08E-29
UCS	Cell metabolism gene	MRPL43	SNRPD2	0.813222097	5.45E-30
UCS	Cell metabolism gene	MRPL43	TIMM50	0.813599698	4.88E-30
UCS	Cell metabolism gene	MRPL43	ACOT8	0.81931135	9.05E-31
UCS	Cell metabolism gene	MRPL43	TIMM13	0.821611767	4.51E-31
UCS	Cell metabolism gene	MRPL43	TIMM8B	0.827746345	6.71E-32
UCS	Cell metabolism gene	MRPL43	EXOSC1	0.828944537	4.59E-32
UCS	Cell metabolism gene	MRPL43	PSMC3	0.829158019	4.29E-32
UCS	Cell metabolism gene	MRPL43	POLR2I	0.830579719	2.71E-32
UCS	Cell metabolism gene	MRPL43	ITPA	0.833778873	9.57E-33
UCS	CGC	MRPL43	MGMT	0.805821592	4.42E-29
UCS	Epifactor	MRPL43	EXOSC4	0.801922879	1.29E-28
UCS	Epifactor	MRPL43	PPP4C	0.8020254	1.25E-28
UCS	Epifactor	MRPL43	SIRT6	0.811132672	9.93E-30
UCS	Epifactor	MRPL43	PRPF31	0.811559812	8.79E-30
UCS	Epifactor	MRPL43	TAF10	0.812364076	6.98E-30
UCS	Epifactor	MRPL43	RUVBL2	0.826084017	1.13E-31
UCS	Epifactor	MRPL43	EXOSC1	0.828944537	4.59E-32
UCS	IUPHAR	MRPL43	SIRT6	0.811132672	9.93E-30
UCS	TF	MRPL43	ZNF428	0.810259925	1.27E-29
UCS	TF	MRPL43	ZNF787	0.812871671	6.03E-30
UCS	TF	MRPL43	ZNF511	0.852960954	1.11E-35
UCS	TSG	MRPL43	SIRT6	0.811132672	9.93E-30
UCS	TSG	MRPL43	PARK7	0.834804166	6.82E-33

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
STAD	MRPL43	MRPL15	-2.15546608137429	0.000334546435624361
LUSC	MRPL43	MRPL44	-1.0353261138043	0.000533204507372277
KIRC	MRPL43	MRPL46	-7.36081421944909	0.0011460554764592
KIRP	MRPL43	MRPL46	-7.17671685013906	0.00123529229313135
KIRP	MRPL43	MRPL19	-1.9689242575519	0.00179363833740354
ESCA	MRPL43	MRPL47	-2.26373711796715	0.001953125
CHOL	MRPL43	MRPL2	-1.49926301466752	0.00390625
CHOL	MRPL43	MRPL3	-2.68429255990621	0.00390625
CHOL	MRPL43	MRPL46	-2.73791743817321	0.00390625
ESCA	MRPL43	MRPL3	-4.97897094908275	0.0048828125
COAD	MRPL43	MRPL15	1.17181689924568	0.00513318181037904
KICH	MRPL43	MRPL19	-2.18550705564541	0.00672554969787598
COAD	MRPL43	MRPL47	-2.29582381838246	0.00863465666770936
ESCA	MRPL43	MRPL17	-1.18756178214998	0.009765625
CHOL	MRPL43	MRPL44	-1.84100898736725	0.01171875
STAD	MRPL43	MRPL47	-1.4008685687155	0.0118026207201183
LIHC	MRPL43	MRPL17	-1.06225729770915	0.0124123499319886
STAD	MRPL43	MRPL4	1.4393539135682	0.0279771662317216
CHOL	MRPL43	MRPL19	-2.09295650388558	0.0390625
LIHC	MRPL43	MRPL47	-6.59586850948538	0.0416658979324166
BLCA	MRPL43	MRPL2	-3.29210657477178	0.0445594787597656
BLCA	MRPL43	MRPL22	-2.25969747792543	0.0493659973144531
KIRC	MRPL43	MRPL47	1.74758475364701	1.00533732476669e-06
LUAD	MRPL43	MRPL2	-1.26727646741024	1.07341296213058e-06
BRCA	MRPL43	MRPL22	-2.3061823226724	1.15724909394453e-08
KICH	MRPL43	MRPL15	1.54522142310359	1.19209289550781e-07
STAD	MRPL43	MRPL17	-3.90880705449186	1.49570405483246e-06
LUSC	MRPL43	MRPL15	-4.43702988385305	1.91594862886626e-08
KIRC	MRPL43	MRPL3	1.69955762234244	1.97132191719422e-08
COAD	MRPL43	MRPL4	2.77705897514473	2.98023223876954e-07
BRCA	MRPL43	MRPL44	-2.66444869593332	3.06751315169682e-08
BRCA	MRPL43	MRPL15	-3.82448964360727	5.49451113259074e-14
LUAD	MRPL43	MRPL44	-3.23791370825974	5.91982739853218e-07
LUAD	MRPL43	MRPL22	-3.64343361732659	6.84976461567817e-06
LUSC	MRPL43	MRPL17	-6.83409683292749	6.93230040561614e-07
LUSC	MRPL43	MRPL2	-2.66710222706783	7.24218086307245e-08
LUAD	MRPL43	MRPL47	-1.74990909879567	9.53955602455483e-07

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MRPL43

ARRB2, DDX56, ICT1, Ybx1, COPS5, CAND1, MRPL47, MRPL40, NDUFA2, LAMTOR3, RPS18, VCAM1, ITGA4, NPM1, SRPK1, FXR2, NACC1, SLK, MRPL39, GLS, MRPL44, MRPL20, NDUFAF5, MRPL4, MRPL42, MALSU1, MRPS30, RPS8, CASQ2, HNRNPA1, AKAP5, MRPL50, MRPL9, MRPL1, Erp44, Brwd3, EGFR, MRPL10, CYLD, LEO1, MRPS11, MRPS23, PMF1, PSMD4, TAZ, DPF2, RECQL4, SERBP1, RPS6, MRM1, HSPD1, PDK1, TRMT61B, AURKAIP1, RC3H1, RC3H2, ALYREF, SNRNP70, PLEKHA4, PRKCI, PXN, SNIP1, GRSF1, PRRC2A, ARHGAP27, ACAD9, AUH, C12orf65, C17orf80, C1QBP, C21orf33, C6orf203, CCDC90B, CHCHD1, CRYZ, CS, DDX28, DHX30, FASTKD2, FASTKD3, FASTKD5, GFM1, GFM2, HINT2, LONP1, LRPPRC, MCU, CCDC109B, MDH2, METTL15, METTL17, MRPL11, MRPS12, MRPS26, MRRF, MTERF3, MTG1, MTG2, MTIF2, MTIF3, MTRF1, MTRF1L, NGRN, PMPCA, PMPCB, RPUSD4, SLIRP, SSBP1, TACO1, TBRG4, TFAM, TMEM70, TRUB2, TSFM, TUFM, VWA8, EXD2, nsp8ab, DNAJA3, DNAJC15, DNAJC19, HSCB, MRPL19, HIST1H1T, DIEXF, MRPL15, NAP1L4, MRPL27, MRPL38, MRPL18, COX4I1, SMAD4, MRPL30, RBMS2, RPL19, MRPL13, YBX2, RPL37, MRPL51, MRPL12, MRPL53, MRPL23, MRPL28, MRPL52, GADD45GIP1, MRPL2, MRPL21, RPL10, MRPL37, KLF15,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MRPL43	BLCA	chr10	102746503	102746503	C	T	Silent		3
MRPL43	BRCA	chr10	102746498	102746499	-	C	Frame_Shift_Ins	p.A158fs	3
MRPL43	PAAD	chr10	102743779	102743779	A	G	Missense_Mutation		2
MRPL43	UCEC	chr10	102746553	102746553	A	G	Missense_Mutation	p.F140L	2
MRPL43	BLCA	chr10	102746534	102746534	C	T	Missense_Mutation	p.R146Q	2
MRPL43	LGG	chr10	102739072	102739072	T	C	Missense_Mutation	p.M196V	2
MRPL43	BLCA	chr10	102741296	102741296	G	A	Missense_Mutation	p.S178L	2
MRPL43	LGG	chr10	102741298	102741298	T	A	Missense_Mutation	p.I220F	2
MRPL43	STAD	chr10	102747079	102747079	C	T	Missense_Mutation	p.R41H	2
MRPL43	STAD	chr10	102739097	102739097	G	T	Silent	p.S187S	2
MRPL43	UCEC	chr10	102739026	102739026	G	A	Missense_Mutation	p.H253H	1
MRPL43	GBM	chr10	102732900	102732900	C	T	Missense_Mutation		1
MRPL43	BLCA	chr10	102743827	102743827	G	C	Missense_Mutation		1
MRPL43	HNSC	chr10	102746724	102746724	C	T	Missense_Mutation	p.A83T	1
MRPL43	SARC	chr10	102738746	102738746	C	A	Missense_Mutation		1
MRPL43	SARC	chr10	102738749	102738749	G	A	Missense_Mutation		1
MRPL43	SKCM	chr10	102743797	102743797	G	A	Missense_Mutation	p.P167L	1
MRPL43	BLCA	chr10	102746590	102746590	C	A	Missense_Mutation	p.Q127H	1
MRPL43	LGG	chr10	102741298	102741298	T	A	Missense_Mutation		1
MRPL43	SKCM	chr10	102739120	102739120	G	A	Missense_Mutation	p.P180S	1
MRPL43	LGG	chr10	102739072	102739072	T	C	Missense_Mutation		1
MRPL43	SKCM	chr10	102741276	102741276	G	A	Missense_Mutation	p.S227F	1
MRPL43	CESC	chr10	102746715	102746715	C	A	Nonsense_Mutation	p.E86*	1
MRPL43	LGG	chr10	102746584	102746584	C	A	Missense_Mutation		1
MRPL43	SKCM	chr10	102746603	102746603	T	C	Missense_Mutation	p.N123S	1
MRPL43	COAD	chr10	102743530	102743530	C	A	Missense_Mutation	p.A213S	1
MRPL43	LIHC	chr10	102739042	102739042	C	T	Missense_Mutation	p.V206I	1
MRPL43	ESCA	chr10	102739014	102739014	G	T	Missense_Mutation	p.S257R	1
MRPL43	LUAD	chr10	102743813	102743813	C	T	Missense_Mutation	p.G162S	1
MRPL43	BLCA	chr10	102746534	102746534	C	T	Missense_Mutation		1
MRPL43	ESCA	chr10	102739014	102739014	G	T	Missense_Mutation		1
MRPL43	LUAD	chr10	102747076	102747076	C	T	Missense_Mutation	p.G42D	1
MRPL43	BLCA	chr10	102741296	102741296	G	A	Missense_Mutation		1
MRPL43	THYM	chr10	102746882	102746882	C	T	Missense_Mutation		1
MRPL43	ESCA	chr10	102746916	102746916	G	T	Silent	p.R57R	1
MRPL43	LUAD	chr10	102746902	102746902	G	A	Silent	p.V61V	1

Copy number variation (CNV) of MRPL43
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MRPL43
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
100341	N/A	AW021215	MRPL43	chr10	102741133	-	C3orf14	chr3	62319901	+
58097	N/A	BF897742	MRPL43	chr10	102743049	-	SEMA4G	chr10	102743193	+
95512	SKCM	TCGA-EB-A42Z-01A	OSBP2	chr22	31137356	+	MRPL43	chr10	102743574	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRP	MRPL43	0.00395683720744542	0.11

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
THCA	MRPL43	0.0247711870387306	0.77
LGG	MRPL43	0.0463806240436381	1
BRCA	MRPL43	0.00187321617764499	0.062
SKCM	MRPL43	0.00875638689836256	0.28
OV	MRPL43	0.0357716145204618	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source