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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: PER2 (NCBI Gene ID:8864)

Gene Summary

Gene Summary

Gene Information	Gene Name: PER2
	Gene ID: 8864
	Gene Symbol	PER2
	Gene ID	8864
	Gene Name	period circadian regulator 2
	Synonyms	FASPS\|FASPS1
	Cytomap	2q37.3
	Type of Gene	protein-coding
	Description	period circadian protein homolog 2circadian clock protein PERIOD 2hPER2period 2period circadian clock 2period circadian protein 2period homolog 2
	Modification date	20200322
	UniProtAcc	O15055

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
PER2	(67.6 - 355.7]

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Translation Studies in PubMed

We searched PubMed using 'PER2[title] AND translation [title] AND human.'

Gene	Title	PMID
PER2	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000254657	239157702	239157853	Frame-shift
ENST00000254657	239159191	239159384	Frame-shift
ENST00000254657	239160239	239160402	Frame-shift
ENST00000254657	239169468	239169594	In-frame
ENST00000254657	239170369	239170478	Frame-shift
ENST00000254657	239171592	239171699	Frame-shift
ENST00000254657	239176696	239176839	Frame-shift
ENST00000254657	239177563	239177615	Frame-shift
ENST00000254657	239179952	239180154	Frame-shift
ENST00000254657	239184383	239184538	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000254657	239169468	239169594	6402	1697	1822	1255	472	514

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
O15055	472	514	1	1255	Chain	ID=PRO_0000162630;Note=Period circadian protein homolog 2
O15055	472	514	480	484	Region	Note=Important for protein stability;Ontology_term=ECO:0000250;evidence=ECO:0000250
O15055	472	514	510	513	Compositional bias	Note=Poly-Arg
O15055	472	514	405	1255	Alternative sequence	ID=VSP_021654;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.1

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
PRAD	PER2	-1.77432194480184	0.000178608522687127
LUSC	PER2	-1.31866002962129	0.00207568534106799
KIRP	PER2	1.83763887776865	0.0394268441013992
HNSC	PER2	-1.31980575090828	3.60935187018186e-05
BRCA	PER2	-2.0731035409237	3.98543424951694e-23

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
LGG	PER2	2	3	0.00824038959150317	0.514383220284238	0.635347117117117	1.63686278455799	1.38808166812211
SARC	PER2	2	3	0.00893782027082029	0.44190123939987	0.643453214285714	-1.62839608703019	-2.28091387241888
UCEC	PER2	2	3	0.0134775892103585	0.442419943064182	0.639290476190476	-0.185569741981724	0.459313349805544

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
UCEC	PER2	0.101121562	0.000435572

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with PER2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type

Gene group

Translation factor

Correlated gene

Coefficient

Pvalue

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRC	PER2	NFIL3	1.65458663071107	0.000447914151479923
THCA	PER2	NFIL3	1.50108548178493	0.000481326335974554
BLCA	PER2	NFIL3	-3.7873156253608	0.000789642333984375
PRAD	PER2	CSNK1D	1.0236823198499	0.000817525595737914
ESCA	PER2	CSNK1E	-5.02596452008167	0.0009765625
PRAD	PER2	ARNTL	1.09197281525639	0.00116785923777763
ESCA	PER2	PER1	-1.87644101155665	0.0029296875
LUAD	PER2	CLOCK	1.77148539133543	0.00334247187092709
COAD	PER2	PER1	2.43545081070662	0.00390031933784485
CHOL	PER2	NFIL3	-5.64262358887123	0.00390625
PRAD	PER2	PER1	-1.03469308198099	0.00394734627371092
HNSC	PER2	PER1	-1.84161141773105	0.0040605245990264
KICH	PER2	BHLHE41	1.24381639305656	0.00460463762283325
LUAD	PER2	CSNK1E	-1.35670012543316	0.00828716227229417
STAD	PER2	CRY1	-2.7588451485014	0.0148032568395138
LUAD	PER2	BTRC	-1.11858843344071	0.0167392488321561
LUAD	PER2	ARNTL	-3.60311479543234	0.0174587811024865
CHOL	PER2	PER1	-3.11511943341677	0.02734375
READ	PER2	CRY2	2.64193303530265	0.03125
READ	PER2	PER1	1.44622135458474	0.03125
ESCA	PER2	CRY1	-5.44692007829672	0.0419921875
HNSC	PER2	CRY1	1.43468738278701	0.043580235555055
KICH	PER2	PER1	-1.30559373431234	0.0482624173164368
LIHC	PER2	CRY1	1.45005965855303	0.0489222263070731
LIHC	PER2	NFIL3	-1.82394590881163	1.09871251804152e-08
KIRP	PER2	PER1	-4.13479209231263	1.11940316855908e-05
THCA	PER2	CSNK1E	-2.60044154408633	1.91546225402467e-08
LUAD	PER2	PER1	-2.8642289741199	2.37450106160718e-08
THCA	PER2	CRY1	-2.38308794674006	2.38403999599936e-07
KIRC	PER2	CSNK1E	-1.29464446080244	2.54891161547424e-12
THCA	PER2	CSNK1D	1.62143312791028	3.14867664036109e-06
KICH	PER2	CRY2	1.08539756615806	3.19480895996094e-05
KICH	PER2	CSNK1E	-3.72558717482887	3.27825546264648e-06
LIHC	PER2	CSNK1D	-1.56329820911015	3.82182903962709e-07
THCA	PER2	CRY2	-1.38025550513524	4.63898797825829e-10
LUAD	PER2	NFIL3	-1.88688647644257	5.67286357063566e-05
KIRP	PER2	CRY2	-1.30637121647836	6.79492950439454e-06
BRCA	PER2	BHLHE41	-3.20131037238342	7.11390880853113e-23
BRCA	PER2	CRY2	-4.85789408592337	7.7582938278184e-31
THCA	PER2	ARNTL	1.92684328560307	8.54197974036578e-08
KICH	PER2	BTRC	2.7130942603117	8.80360603332519e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with PER2

CRY1, PER3, CRY2, Csnk1e, ELAVL1, BTRC, TP53, TPT1, MDM2, CSNK1E, CSNK2B, DEC1, CSNK1D, RORC, CLOCK, BHLHE41, PML, FBXW11, Ppp1ca, PPP1CA, KIAA1429, TCEB3, MLH1, UBL4A, LMO4, LENG8, PER1, LOC400927-CSNK1E, GOLGA3, KIAA0196, KIF23, ZNF618, LOC81691, APPBP2, MCC, CCDC53, PLD1, CEP78, GAPVD1, FAM92A1, DZIP1, SLMAP, KIAA1033, ASPM, ACAD11, JUN, PIP5K1A, TTLL5, FAM83H, SAV1, WASH3P, ARNTL, HK1, MCM3, IMPDH2, TAGLN2, PCCA, PCCB, MCCC1, NME1, CYB5R3, RAB1A, HSP90AA1, RPL39, MCCC2, CCT2, PRKCA, VCP, YWHAE, ALDOA, SSB, HNRNPA2B1, RALY, MDH2, CLTC, LMNA, CCT7, HADHA, AHNAK, HSP90B1, SEPT7, EIF3E, MATR3, AURKAIP1, GSN, SYNCRIP, MYH14, PRKD1, PSMC4, ACACA, PRKD3, SFPQ, CPNE9, FASN, GPI, TLN1, SMCHD1, FLNC, HIST1H2BJ, NME2, ENO1, YWHAZ, HMGA1, EEF2, PLEC, PGK1, HNRNPA1, VDAC1, HMGB1P1, PDIA6, HNRNPH2, RPS19, RPL36, HSD17B10, FLNA, RAB5B, KPNB1, APMAP, G6PD, HNRNPA3, EZR, CCT8, SPR, KRT6A, CAPZB, KRT17, ACTN1, RAP1BL, PAICS, CS, ACTN4, CPNE8, HNRNPH3, P4HB, DDOST, LRPPRC, TFRC, MAGEC1, CKAP4, ERO1L, GFPT2, HID1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
PER2	chr2	239155173	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
PER2	chr2	239160264	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PER2	chr2	239161701	G	A	single_nucleotide_variant	Uncertain_significance	Familial_advanced_sleep_phase_syndrome_1	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PER2	chr2	239161805	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PER2	chr2	239162082	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PER2	chr2	239162198	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PER2	chr2	239164314	C	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PER2	chr2	239164433	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PER2	chr2	239164504	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PER2	chr2	239165633	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PER2	chr2	239165644	T	C	single_nucleotide_variant	Pathogenic	Familial_advanced_sleep_phase_syndrome_1	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PER2	chr2	239165663	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PER2	chr2	239167008	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PER2	chr2	239167024	T	C	single_nucleotide_variant	Uncertain_significance	Sleep_disturbance	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PER2	chr2	239169585	G	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PER2	chr2	239170938	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PER2	chr2	239170960	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PER2	chr2	239171651	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PER2	chr2	239176844	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
PER2	chr2	239180047	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PER2	chr2	239180129	AG	A	Deletion	Pathogenic	Familial_advanced_sleep_phase_syndrome_1	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
PER2	chr2	239181741	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PER2	chr2	239181810	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PER2	chr2	239184412	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PER2	chr2	239184430	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PER2	chr2	239184523	C	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PER2	chr2	239184523	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PER2	chr2	239186362	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PER2	chr2	239186363	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
PER2	CHOL	chr2	239164502	239164502	C	A	Missense_Mutation	p.G706C	6
PER2	LUAD	chr2	239186473	239186473	G	A	Silent	p.S35S	5
PER2	BRCA	chr2	239164479	239164479	G	A	Silent	p.L713	4
PER2	BRCA	chr2	239181710	239181710	C	T	Splice_Site	e4+1	4
PER2	LIHC	chr2	239161968	239161968	G	-	Frame_Shift_Del	p.P899fs	4
PER2	BRCA	chr2	239181776	239181776	C	G	Missense_Mutation	p.D169H	4
PER2	KIRP	chr2	239184526	239184526	A	C	Silent	p.S102S	4
PER2	LIHC	chr2	239168663	239168663	T	-	Frame_Shift_Del	p.N525fs	4
PER2	PAAD	chr2	239161903	239161903	G	A	Missense_Mutation	p.P921S	3
PER2	ESCA	chr2	239184491	239184491	G	A	Missense_Mutation	p.T114I	3
PER2	LIHC	chr2	239161713	239161713	C	A	Missense_Mutation	p.R984L	3
PER2	LUAD	chr2	239161729	239161729	G	T	Missense_Mutation	p.P979T	3
PER2	PAAD	chr2	239180010	239180010	A	G	Missense_Mutation	p.F239L	3
PER2	ESCA	chr2	239185809	239185809	C	T	Missense_Mutation	p.A86T	3
PER2	UCEC	chr2	239165670	239165670	G	A	Missense_Mutation	p.S653L	3
PER2	UCEC	chr2	239159207	239159207	T	C	Missense_Mutation	p.Y1151C	3
PER2	LUAD	chr2	239157729	239157729	C	A	Missense_Mutation	p.G1198C	3
PER2	LUAD	chr2	239157728	239157728	C	A	Missense_Mutation	p.G1198V	3
PER2	PRAD	chr2	239176769	239176769	G	A	Missense_Mutation	p.R299W	3
PER2	BRCA	chr2	239164504	239164504	G	A	Missense_Mutation	p.A705V	3
PER2	UCS	chr2	239174207	239174207	C	A	Missense_Mutation	p.R331I	3
PER2	ESCA	chr2	239180087	239180087	G	A	Missense_Mutation	p.S213F	3
PER2	LIHC	chr2	239161713	239161713	C	A	Missense_Mutation		3
PER2	SKCM	chr2	239161976	239161976	G	A	Silent	p.F896F	3
PER2	KIRP	chr2	239162231	239162231	G	A	Silent	p.T811T	3
PER2	SKCM	chr2	239162337	239162337	G	A	Missense_Mutation	p.P776L	3
PER2	ESCA	chr2	239162260	239162260	C	T	Missense_Mutation	p.V802I	3
PER2	STAD	chr2	239161703	239161703	C	T	Silent	p.S987S	2
PER2	UCEC	chr2	239169537	239169537	C	T	Missense_Mutation	p.E492K	2
PER2	BLCA	chr2	239167208	239167208	C	T	Missense_Mutation	p.E569K	2
PER2	SKCM	chr2	239162210	239162210	G	A	Silent	p.S818S	2
PER2	STAD	chr2	239186494	239186494	C	T	Silent	p.L28L	2
PER2	UCEC	chr2	239170883	239170883	T	C	Missense_Mutation	p.N419S	2
PER2	SKCM	chr2	239164311	239164311	C	T	Silent	p.Q769Q	2
PER2	BLCA	chr2	239185835	239185835	C	T	Splice_Site		2
PER2	SKCM	chr2	239180104	239180104	G	A	Silent	p.I207I	2
PER2	HNSC	chr2	239180022	239180022	C	T	Missense_Mutation	p.D235N	2
PER2	KIRP	chr2	239176835	239176850	GGACACTGCGGAGAAG	-	In_Frame_Del	p.275_277del	2
PER2	CESC	chr2	239157709	239157709	G	A	Silent		2
PER2	STAD	chr2	239167156	239167156	C	A	Missense_Mutation	p.C586F	2
PER2	UCEC	chr2	239170966	239170966	C	A	Missense_Mutation	p.Q391H	2
PER2	SKCM	chr2	239165600	239165600	G	A	Silent	p.I676I	2
PER2	PAAD	chr2	239159221	239159221	G	A	Silent	p.S1146S	2
PER2	SKCM	chr2	239155103	239155103	A	T	Silent	p.I1227I	2
PER2	ESCA	chr2	239157804	239157804	G	T	Missense_Mutation	p.Q1173K	2
PER2	KIRP	chr2	239176835	239176850	GGACACTGCGGAGAAG	-	Splice_Site	p.S275_splice	2
PER2	STAD	chr2	239162215	239162215	C	T	Missense_Mutation		2
PER2	UCEC	chr2	239177590	239177590	C	T	Silent	p.E266	2
PER2	LUAD	chr2	239165693	239165693	C	A	Silent	p.T645T	2
PER2	SKCM	chr2	239179979	239179979	G	A	Missense_Mutation	p.P249L	2
PER2	PAAD	chr2	239161789	239161789	G	T	Missense_Mutation	p.P959T	2
PER2	ESCA	chr2	239161960	239161960	G	T	Missense_Mutation	p.P902T	2
PER2	LIHC	chr2	239161983	239161983	G	-	Frame_Shift_Del	p.P895fs	2
PER2	CESC	chr2	239161691	239161691	G	A	Silent		2
PER2	STAD	chr2	239162215	239162215	C	T	Missense_Mutation	p.V817M	2
PER2	STAD	chr2	239170935	239170935	C	A	Missense_Mutation	p.A402S	2
PER2	UCEC	chr2	239179955	239179955	G	A	Missense_Mutation	p.A257V	2
PER2	SKCM	chr2	239161888	239161888	G	A	Missense_Mutation	p.P926S	2
PER2	SKCM	chr2	239167210	239167210	G	A	Missense_Mutation	p.P568L	2
PER2	ESCA	chr2	239185809	239185809	C	T	Missense_Mutation		2
PER2	SARC	chr2	239170424	239170424	G	C	Silent		2
PER2	CESC	chr2	239180028	239180028	G	A	Missense_Mutation		2
PER2	STAD	chr2	239162026	239162026	C	T	Missense_Mutation	p.A880T	2
PER2	UCEC	chr2	239155019	239155019	C	T	Silent	p.T1255	2
PER2	STAD	chr2	239162216	239162216	G	A	Silent	p.P816P	2
PER2	UCEC	chr2	239184432	239184432	T	C	Missense_Mutation	p.T134A	2
PER2	SKCM	chr2	239161929	239161929	G	A	Missense_Mutation	p.S912F	2
PER2	ESCA	chr2	239184491	239184491	G	A	Missense_Mutation		2
PER2	HNSC	chr2	239165636	239165636	C	T	Silent		2
PER2	UCEC	chr2	239159208	239159208	A	G	Missense_Mutation	p.Y1151H	2
PER2	STAD	chr2	239161666	239161666	G	A	Missense_Mutation	p.P1000S	2
PER2	UCEC	chr2	239186400	239186400	C	T	Missense_Mutation	p.D60N	2
PER2	SKCM	chr2	239184504	239184504	C	T	Missense_Mutation	p.E110K	2
PER2	ESCA	chr2	239162260	239162260	C	T	Missense_Mutation		2
PER2	THYM	chr2	239177604	239177604	G	T	Missense_Mutation	p.Q262K	2
PER2	LIHC	chr2	239160366	239160366	G	-	Frame_Shift_Del	p.L1050fs	2
PER2	SARC	chr2	239155060	239155060	C	T	Missense_Mutation		2
PER2	UCEC	chr2	239159251	239159251	G	T	Silent	p.I1136	2
PER2	STAD	chr2	239162209	239162209	C	T	Missense_Mutation	p.A819T	2
PER2	SKCM	chr2	239161848	239161848	G	A	Missense_Mutation	p.S939F	2
PER2	LIHC	chr2	239161630	239161630	C	-	Frame_Shift_Del	p.A1012fs	2
PER2	LUAD	chr2	239164312	239164312	T	A	Missense_Mutation	p.Q769L	2
PER2	STAD	chr2	239181712	239181712	G	A	Missense_Mutation	p.A190V	2
PER2	UCEC	chr2	239161713	239161713	C	T	Missense_Mutation	p.R984H	2
PER2	BLCA	chr2	239184478	239184478	C	T	Silent	p.L118L	2
PER2	PAAD	chr2	239161789	239161789	G	T	Missense_Mutation		2
PER2	SKCM	chr2	239176773	239176773	C	T	Silent	p.K297K	2
PER2	LUAD	chr2	239185819	239185819	G	T	Missense_Mutation	p.S82R	2
PER2	STAD	chr2	239161846	239161846	C	G	Missense_Mutation	p.E940Q	2
PER2	UCEC	chr2	239161838	239161838	G	T	Silent	p.A942	2
PER2	PAAD	chr2	239161903	239161903	G	A	Missense_Mutation		2
PER2	LIHC	chr2	239168627	239168627	T	-	Frame_Shift_Del	p.K539fs	2
PER2	SKCM	chr2	239169470	239169470	G	A	Splice_Site	p.A514_splice	2
PER2	STAD	chr2	239159277	239159277	T	C	Missense_Mutation	p.I1128V	2
PER2	UCEC	chr2	239168626	239168626	C	A	Missense_Mutation	p.K537N	2
PER2	LUAD	chr2	239161618	239161618	C	T	Missense_Mutation	p.A1016T	2
PER2	LUAD	chr2	239161571	239161571	C	T	Silent	p.Q1031Q	2
PER2	SARC	chr2	239155060	239155060	C	T	Missense_Mutation	p.E1242K	2
PER2	PAAD	chr2	239180010	239180010	A	G	Missense_Mutation		2
PER2	LIHC	chr2	239161897	239161897	C	T	Missense_Mutation		2
PER2	SKCM	chr2	239181733	239181733	G	A	Missense_Mutation	p.S183F	2
PER2	LGG	chr2	239161906	239161906	G	T	Missense_Mutation	p.L920M	1
PER2	LUAD	chr2	239162142	239162142	C	T	Missense_Mutation	p.C841Y	1
PER2	LUAD	chr2	239160389	239160389	G	A	Missense_Mutation	p.S1042L	1
PER2	SARC	chr2	239170424	239170424	G	C	Silent	p.A454	1
PER2	BLCA	chr2	239185789	239185789	T	C	Silent		1
PER2	COAD	chr2	239155053	239155053	C	T	Missense_Mutation	p.G1244E	1
PER2	SKCM	chr2	239169470	239169470	G	A	Missense_Mutation	p.A514V	1
PER2	STAD	chr2	239164366	239164366	A	G	Missense_Mutation	p.L751P	1
PER2	HNSC	chr2	239162045	239162045	G	A	Silent	p.H873H	1
PER2	KIRP	chr2	239155118	239155118	T	A	Silent	p.P1222P	1
PER2	LIHC	chr2	239167220	239167220	C	-	Frame_Shift_Del	p.V565fs	1
PER2	PRAD	chr2	239160292	239160292	C	A	Silent	p.S1074S	1
PER2	SKCM	chr2	239161832	239161832	G	C	Silent	p.A944A	1
PER2	CESC	chr2	239155076	239155076	C	A	Silent		1
PER2	GBM	chr2	239157720	239157720	C	T	Missense_Mutation	p.A1201T	1
PER2	UCEC	chr2	239180057	239180057	C	T	Missense_Mutation	p.S223N	1
PER2	LGG	chr2	239186389	239186389	C	A	Missense_Mutation	p.K63N	1
PER2	LUAD	chr2	239170885	239170885	G	A	Silent	p.I418I	1
PER2	COAD	chr2	239161750	239161750	C	A	Missense_Mutation	p.A972S	1
PER2	BLCA	chr2	239184400	239184400	G	A	Silent	p.S144S	1
PER2	STAD	chr2	239181794	239181794	C	T	Missense_Mutation	p.G163S	1
PER2	LIHC	chr2	239161961	239161961	C	T	Silent	p.A901A	1
PER2	LIHC	chr2	239170423	239170423	G	-	Frame_Shift_Del	p.L455fs	1
PER2	PRAD	chr2	239157852	239157852	T	G	Splice_Site	p.N1157H	1
PER2	SKCM	chr2	239168679	239168679	C	T	Missense_Mutation	p.G520S	1
PER2	GBM	chr2	239186537	239186537	G	T	Missense_Mutation		1
PER2	SKCM	chr2	239186556	239186556	G	A	Missense_Mutation	p.P8S	1
PER2	LGG	chr2	239180112	239180112	G	A	Silent	p.L205L	1
PER2	LUAD	chr2	239180143	239180143	C	T	Silent	p.A194A	1
PER2	LUAD	chr2	239157728	239157729	CC	AA	Missense_Mutation	p.G1198F	1
PER2	BLCA	chr2	239167208	239167208	C	T	Missense_Mutation		1
PER2	COAD	chr2	239164340	239164340	A	G	Missense_Mutation	p.Y760H	1
PER2	BLCA	chr2	239184431	239184431	G	A	Missense_Mutation	p.T134M	1
PER2	STAD	chr2	239169471	239169471	C	A	Missense_Mutation	p.A514S	1
PER2	HNSC	chr2	239170871	239170871	C	T	Missense_Mutation	p.R423K	1
PER2	LIHC	chr2	239184515	239184515	T	A	Missense_Mutation	p.D106V	1
PER2	LIHC	chr2	239161814	239161814	G	-	Frame_Shift_Del	p.P950fs	1
PER2	READ	chr2	239162337	239162337	G	T	Missense_Mutation	p.P776H	1
PER2	CESC	chr2	239161826	239161826	C	G	Missense_Mutation		1
PER2	GBM	chr2	239157759	239157759	G	A	Missense_Mutation		1
PER2	STAD	chr2	239157776	239157777	CT	-	Frame_Shift_Del	p.1182_1182del	1
PER2	LGG	chr2	239161906	239161906	G	T	Missense_Mutation		1
PER2	LUSC	chr2	239159302	239159302	A	T	Silent	p.T1119T	1
PER2	BLCA	chr2	239184400	239184400	G	A	Silent		1
PER2	COAD	chr2	239165636	239165636	C	T	Silent	p.A664A	1
PER2	SKCM	chr2	239171671	239171671	G	A	Nonsense_Mutation	p.Q359X	1
PER2	BLCA	chr2	239170926	239170926	C	T	Missense_Mutation	p.G405R	1
PER2	SKCM	chr2	239168678	239168678	C	T	Missense_Mutation	p.G520D	1
PER2	STAD	chr2	239157776	239157777	CT	-	Frame_Shift_Del	p.S1182fs	1
PER2	HNSC	chr2	239170870	239170870	C	T	Missense_Mutation	p.E388K	1
PER2	LIHC	chr2	239165617	239165617	T	C	Missense_Mutation	p.S671G	1
PER2	KIRP	chr2	239162113	239162113	G	C	Missense_Mutation	p.P851A	1
PER2	READ	chr2	239170947	239170947	T	C	Missense_Mutation	p.I398V	1
PER2	GBM	chr2	239171594	239171594	C	A	Missense_Mutation		1
PER2	UCEC	chr2	239161838	239161838	G	T	Silent	p.A942A	1
PER2	LGG	chr2	239186389	239186389	C	A	Missense_Mutation		1
PER2	LUSC	chr2	239161815	239161815	G	A	Missense_Mutation	p.P950L	1
PER2	BLCA	chr2	239184431	239184431	G	A	Missense_Mutation		1
PER2	COAD	chr2	239170971	239170971	C	T	Missense_Mutation	p.G390R	1
PER2	PAAD	chr2	239162300	239162300	C	T	Nonsense_Mutation		1
PER2	BLCA	chr2	239161853	239161853	G	C	Silent	p.L937L	1
PER2	SKCM	chr2	239162201	239162201	G	A	Silent	p.P821P	1
PER2	THYM	chr2	239169546	239169546	C	T	Missense_Mutation		1
PER2	HNSC	chr2	239170870	239170871	CC	TT	Missense_Mutation	p.R423K	1
PER2	LIHC	chr2	239184411	239184411	C	A	Missense_Mutation	p.A141S	1
PER2	KIRP	chr2	239186362	239186362	C	T	Silent	p.P72P	1
PER2	LIHC	chr2	239161765	239161765	C	-	Frame_Shift_Del	p.A967fs	1
PER2	GBM	chr2	239161798	239161798	G	A	Missense_Mutation		1
PER2	LIHC	chr2	239180001	239180001	A	G	Missense_Mutation		1
PER2	LUSC	chr2	239184406	239184406	G	A	Silent	p.L142L	1
PER2	SKCM	chr2	239170938	239170938	G	A	Missense_Mutation	p.R401C	1
PER2	BLCA	chr2	239170926	239170926	C	T	Missense_Mutation		1
PER2	COAD	chr2	239177587	239177587	C	A	Missense_Mutation	p.E267D	1
PER2	PCPG	chr2	239186523	239186523	C	A	Missense_Mutation	p.V19L	1
PER2	BLCA	chr2	239157733	239157733	C	T	Silent	p.T1196T	1
PER2	SKCM	chr2	239171671	239171671	G	A	Nonsense_Mutation	p.Q359*	1
PER2	THYM	chr2	239170449	239170449	G	T	Missense_Mutation		1
PER2	KIRC	chr2	239180147	239180147	A	G	Missense_Mutation	p.F193S	1
PER2	LIHC	chr2	239155099	239155099	A	G	Missense_Mutation	p.S1229P	1
PER2	KIRP	chr2	239171653	239171653	G	T	Missense_Mutation		1
PER2	LIHC	chr2	239162286	239162286	T	-	Frame_Shift_Del	p.K793fs	1
PER2	SARC	chr2	239159269	239159269	G	A	Silent		1
PER2	CESC	chr2	239161826	239161826	C	G	Missense_Mutation	p.Q946H	1
PER2	STAD	chr2	239162263	239162263	G	A	Missense_Mutation	p.R801W	1
PER2	COAD	chr2	239186363	239186363	G	A	Missense_Mutation	p.P72L	1
PER2	HNSC	chr2	239180022	239180022	C	T	Missense_Mutation		1
PER2	LIHC	chr2	239171593	239171593	T	C	Missense_Mutation		1
PER2	LUSC	chr2	239155051	239155051	A	T	Missense_Mutation	p.S1245T	1
PER2	BLCA	chr2	239161853	239161853	G	C	Silent		1
PER2	SKCM	chr2	239162251	239162251	G	A	Nonsense_Mutation	p.R805*	1
PER2	SKCM	chr2	239167214	239167214	A	C	Missense_Mutation	p.F567V	1
PER2	KIRC	chr2	239181758	239181758	C	T	Missense_Mutation	p.V175M	1
PER2	KIRP	chr2	239162231	239162231	G	A	Silent		1
PER2	LUAD	chr2	239170885	239170885	G	A	Nonsense_Mutation	p.Q383*	1
PER2	CESC	chr2	239180028	239180028	G	A	Missense_Mutation	p.P233S	1
PER2	STAD	chr2	239162198	239162198	C	T	Silent	p.P822P	1
PER2	BLCA	chr2	239167177	239167177	C	T	Missense_Mutation	p.C579Y	1
PER2	COAD	chr2	239186427	239186427	G	A	Missense_Mutation	p.R51W	1
PER2	UCS	chr2	239174207	239174207	C	A	Missense_Mutation		1
PER2	HNSC	chr2	239162038	239162038	A	G	Missense_Mutation		1
PER2	LIHC	chr2	239167286	239167286	C	T	Splice_Site		1
PER2	OV	chr2	238831994	238831994	T	C	Missense_Mutation		1
PER2	PRAD	chr2	239167146	239167146	G	A	Silent	p.S589S	1
PER2	SKCM	chr2	239161916	239161916	C	T	Silent	p.G916G	1
PER2	ESCA	chr2	239162134	239162134	C	T	Missense_Mutation	p.V844M	1
PER2	SKCM	chr2	239161732	239161732	G	A	Missense_Mutation	p.P978S	1
PER2	THYM	chr2	239170449	239170449	G	T	Missense_Mutation	p.A446D	1
PER2	KIRP	chr2	239167228	239167228	C	G	Missense_Mutation	p.S562T	1
PER2	KIRP	chr2	239184526	239184526	A	C	Silent		1
PER2	LUAD	chr2	239186426	239186426	C	G	Missense_Mutation	p.R51P	1
PER2	SARC	chr2	239166971	239166971	G	T	Missense_Mutation		1
PER2	CESC	chr2	239161691	239161691	G	A	Silent	p.L991	1
PER2	COAD	chr2	239166973	239166973	G	A	Missense_Mutation	p.A615V	1
PER2	STAD	chr2	239161605	239161605	G	A	Missense_Mutation	p.A1020V	1
PER2	HNSC	chr2	239170870	239170870	C	T	Missense_Mutation		1
PER2	LIHC	chr2	239155099	239155099	A	G	Missense_Mutation		1
PER2	PRAD	chr2	239157852	239157852	T	G	Splice_Site	p.N1157_splice	1
PER2	SKCM	chr2	239170983	239170983	G	A	Missense_Mutation	p.P350L	1
PER2	SKCM	chr2	239161733	239161733	G	A	Silent	p.S977S	1
PER2	THYM	chr2	239161815	239161815	G	T	Missense_Mutation	p.P950H	1
PER2	KIRP	chr2	239164455	239164455	C	T	Silent	p.K721K	1
PER2	LGG	chr2	239176786	239176786	G	A	Missense_Mutation	p.P293L	1
PER2	LUAD	chr2	239169510	239169510	T	A	Missense_Mutation	p.S501C	1
PER2	SARC	chr2	239170424	239170424	G	C	Silent	p.A454A	1
PER2	BLCA	chr2	239184478	239184478	C	T	Silent		1
PER2	BLCA	chr2	239185789	239185789	T	C	Silent	p.P92P	1
PER2	DLBC	chr2	239162025	239162025	G	A	Missense_Mutation	p.A880V	1
PER2	STAD	chr2	239176732	239176732	A	C	Missense_Mutation	p.L311R	1
PER2	HNSC	chr2	239170871	239170871	C	T	Missense_Mutation		1
PER2	PRAD	chr2	239181795	239181795	C	G	Missense_Mutation	p.E162D	1
PER2	SKCM	chr2	239162200	239162200	G	A	Missense_Mutation	p.P822S	1
PER2	GBM	chr2	239161798	239161798	G	A	Missense_Mutation	p.P956S	1
PER2	THYM	chr2	239169546	239169546	C	T	Missense_Mutation	p.G489R	1
PER2	LGG	chr2	239162052	239162052	G	A	Missense_Mutation	p.P871L	1
PER2	BLCA	chr2	239169492	239169492	C	T	Missense_Mutation		1
PER2	CHOL	chr2	239166978	239166978	G	T	Silent	p.V613V	1
PER2	BLCA	chr2	239169492	239169492	C	T	Missense_Mutation	p.E507K	1
PER2	STAD	chr2	239186565	239186565	C	T	Missense_Mutation	p.A5T	1
PER2	HNSC	chr2	239162045	239162045	G	A	Silent		1
PER2	PRAD	chr2	239160327	239160327	C	A	Nonsense_Mutation	p.E1063*	1
PER2	SKCM	chr2	239169517	239169517	G	A	Silent	p.T498T	1
PER2	BRCA	chr2	239162318	239162318	G	A	Silent	p.S782	1
PER2	GBM	chr2	239157759	239157759	G	A	Missense_Mutation	p.R1188C	1
PER2	UCEC	chr2	239165682	239165682	G	C	Missense_Mutation	p.T649R	1

Copy number variation (CNV) of PER2
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across PER2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
64304	N/A	BF508504	FAM98B	chr15	38776781	-	PER2	chr2	239173954	+
64304	N/A	AF370406	HDAC4	chr2	239583758	-	PER2	chr2	239182157	-
64304	BRCA	TCGA-A7-A26G-01A	ILKAP	chr2	239090706	-	PER2	chr2	239157853	-
64304	N/A	BF752946	LRSAM1	chr9	130259185	+	PER2	chr2	239179729	+
91910	SKCM	TCGA-D3-A3MO-06A	PER2	chr2	239157703	-	HDAC4	chr2	240037006	-
64305	N/A	BF825009	PER2	chr2	239153978	-	PER2	chr2	239154177	+
79580	PRAD	TCGA-HC-A8D0-01A	PER2	chr2	239154932	-	SEPT2	chr2	242254985	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	PER2	0.00187157036685065	0.052
KIRP	PER2	0.00229759297896398	0.062
BLCA	PER2	0.0155406481350284	0.4
ESCA	PER2	0.0185962896549781	0.46
MESO	PER2	0.0280398087241202	0.67

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
THCA	PER2	0.00416870715017342	0.14
GBM	PER2	0.00957184459812268	0.31
LGG	PER2	0.0481263778114004	1
SARC	PER2	0.0335696515903575	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0011570	Mental Depression	5	PSYGENET
C0011581	Depressive disorder	5	PSYGENET
C0005586	Bipolar Disorder	4	PSYGENET
C0038587	Substance Withdrawal Syndrome	2	CTD_human
C0221074	Depression, Postpartum	2	PSYGENET
C0600427	Cocaine Dependence	2	PSYGENET
C0001969	Alcoholic Intoxication	1	CTD_human
C0023473	Myeloid Leukemia, Chronic	1	CTD_human
C1858496	Advanced Sleep-Phase Syndrome, Familial	1	CTD_human;ORPHANET
C3807327	ADVANCED SLEEP PHASE SYNDROME, FAMILIAL, 1	1	GENOMICS_ENGLAND;UNIPROT