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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: NEMF (NCBI Gene ID:9147)

Gene Summary

Gene Summary

Gene Information	Gene Name: NEMF
	Gene ID: 9147
	Gene Symbol	NEMF
	Gene ID	9147
	Gene Name	nuclear export mediator factor
	Synonyms	NY-CO-1\|SDCCAG1
	Cytomap	14q21.3
	Type of Gene	protein-coding
	Description	nuclear export mediator factor NEMFantigen NY-CO-1serologically defined colon cancer antigen 1
	Modification date	20200313
	UniProtAcc	O60524

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006414	Translational elongation
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
NEMF	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'NEMF[title] AND translation [title] AND human.'

Gene	Title	PMID
NEMF	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000298310	50251809	50251853	Frame-shift
ENST00000298310	50253435	50253468	In-frame
ENST00000298310	50269170	50269291	Frame-shift
ENST00000298310	50269386	50269445	Frame-shift
ENST00000298310	50272738	50272851	Frame-shift
ENST00000298310	50280705	50280768	In-frame
ENST00000298310	50298768	50298844	Frame-shift
ENST00000298310	50300140	50300214	Frame-shift
ENST00000298310	50307435	50307584	Frame-shift
ENST00000298310	50312857	50312983	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000298310	50253435	50253468	5055	3346	3378	1076	965	976
ENST00000298310	50280705	50280768	5055	2132	2194	1076	560	581
ENST00000298310	50312857	50312983	5055	682	807	1076	77	119

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type

Translation factor

adj.pval

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with NEMF (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type

Gene group

Translation factor

Correlated gene

Coefficient

Pvalue

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
BLCA	NEMF	RPL5	-3.50581551367555	0.00026702880859375
STAD	NEMF	RPL5	2.24361928856279	0.000433447770774365
LIHC	NEMF	RPL8	-4.84588284974558	0.00110314154326131
THCA	NEMF	RPL13A	1.00055529557489	0.00121938003080576
ESCA	NEMF	TCF25	2.00435474876057	0.0048828125
THCA	NEMF	ANKZF1	-3.43650164630031	0.00681094256685597
KIRP	NEMF	ANKZF1	-1.61132866975132	0.0105091729201376
LUSC	NEMF	RPL23	-3.65655157280645	0.0157928575534704
BRCA	NEMF	RPL23A	-1.00708839787202	0.0188078315893149
KICH	NEMF	RPL5	1.79380241489629	0.0219083428382874
UCEC	NEMF	ANKZF1	2.7268611217094	0.046875
KICH	NEMF	ANKZF1	1.27322087580613	1.0073184967041e-05
KIRC	NEMF	RPL13A	-2.22570045477256	1.02382991067149e-08
KIRC	NEMF	ANKZF1	-2.12424646752068	1.03420313223267e-10
KIRP	NEMF	RPL23A	-1.52936455976751	1.2875534594059e-06
KIRC	NEMF	TCF25	-1.15044290242785	1.45266993448751e-06
LUSC	NEMF	ANKZF1	-2.85359504487486	1.96457667164042e-06
KIRP	NEMF	RPL23	-3.16602228862164	2.00420618057251e-06
KIRC	NEMF	RPL35	-1.06475238059392	2.72286325678163e-08
LUAD	NEMF	ANKZF1	-3.18847532900235	3.64267431164553e-07
LIHC	NEMF	ANKZF1	-3.17956706455575	4.0207800187107e-07
KIRC	NEMF	RPL8	-1.18252459971773	5.64962994208288e-07
BRCA	NEMF	TCF25	2.20042599781085	5.84048483443751e-11
KIRP	NEMF	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	NEMF	RPL11	-5.47536848868151	6.13619476098216e-10
KIRC	NEMF	RPL23	-4.40036780721891	6.64395189280361e-09
STAD	NEMF	ANKZF1	-1.1841020236204	6.68526627123356e-05
LUAD	NEMF	RPL23A	-2.22526108535187	7.13242533835451e-05
KIRP	NEMF	RPL35	-1.52981101975496	9.0546440333128e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with NEMF

NOP56, RPL11, ZNF622, LTN1, ZBTB38, COX5A, DDX18, DHX15, EIF2S2, NTRK1, IFI16, RPL10, XRCC3, THOC5, HAUS2, MMGT1, Tipin, Rpl35, Ccdc77, Sept6, SEC61B, HYPK, ZNF786, CYP4V2, ZNF490, STK11, ORMDL1, ANKRD18A, GYPA, FADS3, HNRNPL, CDC16, EXOSC4, MED17, PAFAH1B1, PSMD1, PSMD4, RAE1, RPL23, RPL30, SNRPG, DIMT1, EFTUD2, DPF2, HABP4, SERBP1, MTMR1, STAU1, WWP2, BRD7, OBSL1, PLEKHA4, nsp9ab, ORF9b, nsp16, GRB7, HADHB, HIST1H2BD, M, N, nsp4, nsp6, ORF3a, ORF7a, UFL1, DDRGK1, SMAD4, KLK12, AKR7L, SPANXN2, TCEAL7, SPCS1, CERS6, C1orf189, PSENEN, KXD1, GNL2, EP300, ZRANB1, FBXW7, OPTN,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
NEMF	chr14	50251670	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant,SO:0001624\|3_prime_UTR_variant	SO:0001819\|synonymous_variant,SO:0001624\|3_prime_UTR_variant
NEMF	chr14	50255883	T	TCTACA	Duplication	Pathogenic	Intellectual_developmental_disorder_with_speech_delay_and_axonal_peripheral_neuropathy	SO:0001587\|nonsense	SO:0001587\|nonsense
NEMF	chr14	50255982	G	A	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
NEMF	chr14	50255990	CT	C	Deletion	Pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
NEMF	chr14	50262509	CT	C	Deletion	Pathogenic	Intellectual_developmental_disorder_with_speech_delay_and_axonal_peripheral_neuropathy	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
NEMF	chr14	50262520	G	A	single_nucleotide_variant	Pathogenic	Intellectual_developmental_disorder_with_speech_delay_and_axonal_peripheral_neuropathy	SO:0001587\|nonsense	SO:0001587\|nonsense
NEMF	chr14	50266225	CTG	C	Microsatellite	Uncertain_significance	Malignant_tumor_of_prostate	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
NEMF	chr14	50269197	AG	A	Deletion	Pathogenic	Intellectual_developmental_disorder_with_speech_delay_and_axonal_peripheral_neuropathy	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
NEMF	chr14	50269252	T	A	single_nucleotide_variant	Pathogenic	Intellectual_developmental_disorder_with_speech_delay_and_axonal_peripheral_neuropathy	SO:0001587\|nonsense	SO:0001587\|nonsense
NEMF	chr14	50269255	G	A	single_nucleotide_variant	Pathogenic	not_provided	SO:0001587\|nonsense	SO:0001587\|nonsense
NEMF	chr14	50295522	A	AG	Insertion	Pathogenic	Intellectual_developmental_disorder_with_speech_delay_and_axonal_peripheral_neuropathy	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
NEMF	chr14	50295523	T	TG	Insertion	Pathogenic	Intellectual_developmental_disorder_with_speech_delay_and_axonal_peripheral_neuropathy	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
NEMF	chr14	50296110	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
NEMF	chr14	50298846	T	G	single_nucleotide_variant	Likely_pathogenic	See_cases\|Intellectual_developmental_disorder_with_speech_delay_and_axonal_peripheral_neuropathy	SO:0001574\|splice_acceptor_variant	SO:0001574\|splice_acceptor_variant
NEMF	chr14	50301142	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
NEMF	chr14	50304856	C	A	single_nucleotide_variant	Likely_pathogenic	Intellectual_developmental_disorder_with_speech_delay_and_axonal_peripheral_neuropathy	SO:0001575\|splice_donor_variant	SO:0001575\|splice_donor_variant
NEMF	chr14	50318287	G	C	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
NEMF	chr14	50318351	G	T	single_nucleotide_variant	Uncertain_significance	Hereditary_breast_and_ovarian_cancer_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
NEMF	chr14	50319471	T	A	single_nucleotide_variant	Pathogenic	not_provided	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
NEMF	LIHC	chr14	50267183	50267183	T	-	Frame_Shift_Del	p.N776fs	5
NEMF	KIRP	chr14	50256253	50256253	C	T	Silent	p.Q886Q	4
NEMF	KIRP	chr14	50292672	50292672	G	A	Splice_Site	p.A497_splice	4
NEMF	LIHC	chr14	50262590	50262590	T	-	Frame_Shift_Del	p.K846fs	3
NEMF	THYM	chr14	50318342	50318342	C	T	Missense_Mutation	p.R57Q	3
NEMF	STAD	chr14	50298924	50298924	C	T	Splice_Site		3
NEMF	LIHC	chr14	50295460	50295460	T	-	Frame_Shift_Del	p.N433fs	3
NEMF	COAD	chr14	50269439	50269439	T	-	Frame_Shift_Del	p.K641fs	3
NEMF	TGCT	chr14	50295773	50295773	T	C	Missense_Mutation		3
NEMF	PRAD	chr14	50251653	50251653	C	T	Missense_Mutation	p.R1048H	3
NEMF	LIHC	chr14	50319457	50319457	A	-	Frame_Shift_Del	p.F5fs	2
NEMF	SARC	chr14	50307453	50307453	A	T	Silent		2
NEMF	UCEC	chr14	50262615	50262615	G	A	Missense_Mutation	p.A838V	2
NEMF	LIHC	chr14	50251848	50251848	T	G	Missense_Mutation		2
NEMF	PAAD	chr14	50318311	50318311	C	A	Missense_Mutation		2
NEMF	CESC	chr14	50312863	50312863	C	G	Missense_Mutation		2
NEMF	SARC	chr14	50295796	50295796	G	C	Missense_Mutation	p.T403R	2
NEMF	UCEC	chr14	50266244	50266244	T	G	Splice_Site	e25-2	2
NEMF	LIHC	chr14	50318359	50318359	T	C	Silent		2
NEMF	KICH	chr14	50272839	50272839	G	A	Missense_Mutation	p.P586L	2
NEMF	LIHC	chr14	50295969	50295969	T	-	Frame_Shift_Del	p.K345fs	2
NEMF	CESC	chr14	50312951	50312951	G	C	Silent		2
NEMF	UCEC	chr14	50267233	50267233	T	G	Missense_Mutation	p.K759N	2
NEMF	LIHC	chr14	50251848	50251848	T	G	Missense_Mutation	p.K1012T	2
NEMF	STAD	chr14	50298924	50298924	C	T	Splice_Site	.	2
NEMF	KIRC	chr14	50295452	50295452	C	T	Missense_Mutation	p.E436K	2
NEMF	LIHC	chr14	50301106	50301106	T	-	Frame_Shift_Del	p.K212fs	2
NEMF	LUAD	chr14	50280705	50280705	C	A	Splice_Site		2
NEMF	UCEC	chr14	50267382	50267382	C	A	Nonsense_Mutation	p.E710*	2
NEMF	BLCA	chr14	50295770	50295770	A	G	Splice_Site		2
NEMF	PAAD	chr14	50318311	50318311	C	A	Missense_Mutation	p.K67N	2
NEMF	LGG	chr14	50269393	50269393	A	C	Silent		2
NEMF	SKCM	chr14	50272836	50272836	G	C	Missense_Mutation	p.P587R	2
NEMF	UCEC	chr14	50272849	50272849	C	A	Nonsense_Mutation	p.E583*	2
NEMF	KIRP	chr14	50292672	50292672	G	A	Missense_Mutation	p.A497V	2
NEMF	CESC	chr14	50272833	50272833	C	T	Missense_Mutation		2
NEMF	HNSC	chr14	50295332	50295332	A	G	Splice_Site		2
NEMF	SKCM	chr14	50295833	50295833	G	A	Missense_Mutation	p.P391S	2
NEMF	UCEC	chr14	50296111	50296111	G	A	Nonsense_Mutation	p.R327*	2
NEMF	UCEC	chr14	50251415	50251415	C	A	Missense_Mutation	p.R1057I	2
NEMF	CESC	chr14	50255997	50255997	G	T	Missense_Mutation		2
NEMF	SKCM	chr14	50295850	50295850	G	A	Missense_Mutation	p.A385V	2
NEMF	UCEC	chr14	50296127	50296127	C	A	Missense_Mutation	p.K321N	2
NEMF	LIHC	chr14	50269987	50269987	T	C	Missense_Mutation	p.E628G	2
NEMF	UCEC	chr14	50251811	50251811	T	G	Missense_Mutation	p.K1024N	2
NEMF	CESC	chr14	50269245	50269245	C	T	Missense_Mutation		2
NEMF	HNSC	chr14	50262630	50262630	G	C	Nonsense_Mutation	p.S833*	2
NEMF	LGG	chr14	50295439	50295439	C	T	Missense_Mutation		2
NEMF	UCEC	chr14	50298052	50298052	C	A	Nonsense_Mutation	p.E304*	2
NEMF	LIHC	chr14	50318359	50318359	T	C	Silent	p.L51L	2
NEMF	UCEC	chr14	50256258	50256258	C	A	Missense_Mutation	p.D885Y	2
NEMF	UCEC	chr14	50298976	50298976	C	A	Missense_Mutation	p.R252I	2
NEMF	LAML	chr14	49332385	49332385	A	G	Silent	p.S831	2
NEMF	UCEC	chr14	50262519	50262519	C	T	Missense_Mutation	p.R870Q	2
NEMF	CESC	chr14	50255978	50255978	C	G	Missense_Mutation		2
NEMF	ESCA	chr14	50251372	50251372	C	G	Silent	p.L1071L	2
NEMF	LIHC	chr14	50251367	50251367	A	C	Missense_Mutation		2
NEMF	UCEC	chr14	50304857	50304857	G	A	Missense_Mutation	p.P192S	2
NEMF	LGG	chr14	50269393	50269393	A	C	Silent	p.L656L	2
NEMF	SARC	chr14	50295796	50295796	G	C	Missense_Mutation		2
NEMF	UCEC	chr14	50262614	50262614	C	T	Silent	p.A838	2
NEMF	CESC	chr14	50256237	50256237	C	T	Missense_Mutation		2
NEMF	LIHC	chr14	50269987	50269987	T	C	Missense_Mutation		2
NEMF	PAAD	chr14	50255946	50255946	T	G	Missense_Mutation		2
NEMF	HNSC	chr14	50272836	50272836	G	-	Frame_Shift_Del	p.P587fs	2
NEMF	CESC	chr14	50256283	50256283	C	T	Missense_Mutation		1
NEMF	GBM	chr14	50267402	50267402	G	A	Missense_Mutation		1
NEMF	LGG	chr14	50262540	50262540	G	A	Missense_Mutation	p.A863V	1
NEMF	CESC	chr14	50312951	50312951	G	C	Silent	p.V88	1
NEMF	SKCM	chr14	50272837	50272837	G	A	Missense_Mutation	p.P587S	1
NEMF	KICH	chr14	50272839	50272839	G	A	Missense_Mutation		1
NEMF	READ	chr14	50266387	50266387	C	A	Missense_Mutation	p.Q794H	1
NEMF	BLCA	chr14	50281502	50281502	C	T	Missense_Mutation	p.E551K	1
NEMF	COAD	chr14	50280756	50280756	A	G	Missense_Mutation	p.V565A	1
NEMF	HNSC	chr14	50280711	50280711	G	T	Missense_Mutation		1
NEMF	LGG	chr14	50307487	50307487	C	T	Missense_Mutation	p.R152H	1
NEMF	LIHC	chr14	50262651	50262651	T	-	Frame_Shift_Del	p.K828fs	1
NEMF	ACC	chr14	50295792	50295792	G	T	Missense_Mutation	p.N404K	1
NEMF	COAD	chr14	50251650	50251650	C	T	Missense_Mutation	p.S1049N	1
NEMF	PAAD	chr14	50296111	50296111	G	T	Silent		1
NEMF	READ	chr14	50295812	50295812	C	A	Nonsense_Mutation	p.E398X	1
NEMF	THYM	chr14	50251943	50251943	G	T	Missense_Mutation	p.N1008K	1
NEMF	BLCA	chr14	50272845	50272845	G	T	Missense_Mutation	p.P584H	1
NEMF	ESCA	chr14	50251372	50251372	C	G	Silent	p.L1071	1
NEMF	HNSC	chr14	50255970	50255970	C	T	Missense_Mutation		1
NEMF	LGG	chr14	50251694	50251694	C	T	Missense_Mutation	p.M1034I	1
NEMF	LUAD	chr14	50307515	50307515	C	T	Missense_Mutation	p.D143N	1
NEMF	SARC	chr14	50307453	50307453	A	T	Silent	p.P163P	1
NEMF	BLCA	chr14	50255908	50255908	G	A	Missense_Mutation		1
NEMF	COAD	chr14	50256049	50256049	T	C	Missense_Mutation	p.N904D	1
NEMF	PAAD	chr14	50318342	50318342	C	A	Missense_Mutation		1
NEMF	READ	chr14	50298977	50298977	T	C	Missense_Mutation	p.R252G	1
NEMF	THYM	chr14	50266222	50266222	G	T	Missense_Mutation	p.S812R	1
NEMF	BLCA	chr14	50267154	50267154	G	C	Missense_Mutation	p.H786D	1
NEMF	ESCA	chr14	50251875	50251875	G	T	RNA	NULL	1
NEMF	CESC	chr14	50272833	50272833	C	T	Missense_Mutation	p.R588Q	1
NEMF	HNSC	chr14	50295348	50295355	ATATGCTG	-	Frame_Shift_Del		1
NEMF	LGG	chr14	50295879	50295879	C	T	Nonsense_Mutation	p.W375*	1
NEMF	SARC	chr14	50262650	50262650	C	T	Silent		1
NEMF	COAD	chr14	50266214	50266214	T	A	Missense_Mutation	p.H815L	1
NEMF	STAD	chr14	50262535	50262535	C	T	Missense_Mutation	p.V865M	1
NEMF	KIRC	chr14	50298067	50298067	A	C	Missense_Mutation	p.F299V	1
NEMF	LIHC	chr14	50251362	50251362	T	-	Frame_Shift_Del	p.R1075fs	1
NEMF	READ	chr14	50267191	50267191	C	A	Missense_Mutation	p.E773D	1
NEMF	UCEC	chr14	50298786	50298786	A	G	Missense_Mutation	p.F289L	1
NEMF	BLCA	chr14	50267267	50267267	G	C	Missense_Mutation	p.S748C	1
NEMF	ESCA	chr14	50267199	50267199	C	A	Missense_Mutation	p.G771W	1
NEMF	CESC	chr14	50263033	50263033	G	A	RNA	NULL	1
NEMF	HNSC	chr14	50312932	50312932	C	A	Missense_Mutation		1
NEMF	LUAD	chr14	50301084	50301084	T	C	Missense_Mutation	p.K220E	1
NEMF	BLCA	chr14	50281502	50281502	C	T	Missense_Mutation		1
NEMF	COAD	chr14	50269254	50269254	C	T	Missense_Mutation	p.R671Q	1
NEMF	PAAD	chr14	50255946	50255946	T	G	Missense_Mutation	p.N938T	1
NEMF	STAD	chr14	50255864	50255864	C	T	Silent	p.K965K	1
NEMF	LIHC	chr14	50256006	50256006	T	-	Frame_Shift_Del	p.K918fs	1
NEMF	READ	chr14	50295945	50295945	C	A	Missense_Mutation	p.M353I	1
NEMF	UCEC	chr14	50267364	50267364	C	T	Missense_Mutation	p.V716M	1
NEMF	ESCA	chr14	50319482	50319482	G	A	RNA	NULL	1
NEMF	CESC	chr14	50269245	50269245	C	T	Missense_Mutation	p.R674K	1
NEMF	LGG	chr14	50295879	50295879	C	T	Nonsense_Mutation		1
NEMF	LUAD	chr14	50272777	50272777	G	T	Silent	p.R607R	1
NEMF	BLCA	chr14	50272845	50272845	G	T	Missense_Mutation		1
NEMF	LIHC	chr14	50266232	50266232	T	G	Missense_Mutation	p.K809T	1
NEMF	STAD	chr14	50269385	50269385	A	G	Splice_Site	.	1
NEMF	LIHC	chr14	50295414	50295414	T	-	Frame_Shift_Del	p.K448fs	1
NEMF	READ	chr14	50296099	50296099	C	T	Missense_Mutation	p.E331K	1
NEMF	ESCA	chr14	50267199	50267199	C	A	Missense_Mutation		1
NEMF	CESC	chr14	50287124	50287124	C	G	RNA	NULL	1
NEMF	HNSC	chr14	50318366	50318366	G	T	Missense_Mutation		1
NEMF	LGG	chr14	50307487	50307487	C	T	Missense_Mutation		1
NEMF	LUAD	chr14	50266231	50266231	T	C	Silent	p.K809K	1
NEMF	BLCA	chr14	50267267	50267267	G	C	Missense_Mutation		1
NEMF	COAD	chr14	50295406	50295406	T	C	Missense_Mutation	p.Q451R	1
NEMF	LIHC	chr14	50301094	50301094	T	-	Frame_Shift_Del	p.K216fs	1
NEMF	SARC	chr14	50301155	50301155	G	T	Missense_Mutation		1
NEMF	ESCA	chr14	50319482	50319482	G	A	Missense_Mutation		1
NEMF	CESC	chr14	50255978	50255978	C	G	Missense_Mutation	p.Q927H	1
NEMF	LUSC	chr14	50272849	50272849	C	T	Missense_Mutation	p.E583K	1
NEMF	SKCM	chr14	50304857	50304857	G	A	Splice_Site	p.P192_splice	1
NEMF	THCA	chr14	50318332	50318332	T	C	Silent		1
NEMF	BLCA	chr14	50269421	50269421	G	C	Nonsense_Mutation	p.S647*	1
NEMF	COAD	chr14	50295789	50295789	A	G	Silent	p.H405H	1
NEMF	HNSC	chr14	50312960	50312960	C	T	Silent	p.R85R	1
NEMF	KIRP	chr14	50256253	50256253	C	T	Silent		1
NEMF	LIHC	chr14	50292632	50292632	T	-	Frame_Shift_Del	p.K510fs	1
NEMF	SARC	chr14	50295019	50295019	G	T	Missense_Mutation		1
NEMF	CESC	chr14	50298815	50298815	G	T	Missense_Mutation		1
NEMF	ESCA	chr14	50251372	50251372	C	G	Silent		1
NEMF	CESC	chr14	50256237	50256237	C	T	Missense_Mutation	p.E892K	1
NEMF	HNSC	chr14	50255970	50255970	C	T	Missense_Mutation	p.R930K	1
NEMF	LGG	chr14	50269996	50269996	G	T	Missense_Mutation		1
NEMF	LUSC	chr14	50295371	50295371	C	T	Missense_Mutation	p.V463I	1
NEMF	SKCM	chr14	50267277	50267277	C	T	Missense_Mutation	p.E745K	1
NEMF	HNSC	chr14	50267223	50267223	A	T	Missense_Mutation	p.S763T	1
NEMF	LIHC	chr14	50251367	50251367	A	C	Missense_Mutation	p.V1073G	1
NEMF	THCA	chr14	50318332	50318332	T	C	Silent	p.T60T	1
NEMF	BLCA	chr14	50255908	50255908	G	A	Missense_Mutation	p.H951Y	1
NEMF	COAD	chr14	50298974	50298974	C	A	Nonsense_Mutation	p.E253X	1
NEMF	LIHC	chr14	50295382	50295382	A	-	Frame_Shift_Del	p.L460fs	1
NEMF	SARC	chr14	50312869	50312869	G	T	Missense_Mutation		1
NEMF	CESC	chr14	50256283	50256283	C	T	Missense_Mutation	p.M876I	1
NEMF	HNSC	chr14	50312932	50312932	C	A	Missense_Mutation	p.V95L	1
NEMF	LUSC	chr14	50266381	50266381	C	A	Missense_Mutation	p.L796F	1
NEMF	SKCM	chr14	50298965	50298965	G	A	Missense_Mutation	p.P256S	1
NEMF	HNSC	chr14	50318366	50318366	G	T	Missense_Mutation	p.T49K	1
NEMF	LIHC	chr14	50252040	50252041	-	A	Splice_Site		1
NEMF	THYM	chr14	50251943	50251943	G	T	Missense_Mutation		1
NEMF	BLCA	chr14	50292663	50292663	G	C	Nonsense_Mutation	p.S500*	1
NEMF	COAD	chr14	50307529	50307529	C	T	Missense_Mutation	p.R138Q	1
NEMF	LIHC	chr14	50318565	50318565	A	-	Frame_Shift_Del	p.Y30fs	1
NEMF	GBM	chr14	50267402	50267402	G	A	Missense_Mutation	p.T703M	1
NEMF	CESC	chr14	50312863	50312863	C	G	Missense_Mutation	p.D118H	1
NEMF	SKCM	chr14	50298783	50298783	C	T	Missense_Mutation	p.E290K	1
NEMF	LIHC	chr14	50295432	50295433	-	T	Frame_Shift_Ins	p.K442fs	1
NEMF	PRAD	chr14	50301159	50301159	G	A	Missense_Mutation	p.P195S	1
NEMF	THYM	chr14	50266222	50266222	G	T	Missense_Mutation		1
NEMF	BLCA	chr14	50267156	50267156	G	A	Missense_Mutation	p.S785F	1
NEMF	COAD	chr14	50318570	50318570	T	G	Missense_Mutation	p.N28T	1

Copy number variation (CNV) of NEMF
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across NEMF
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
101171	N/A	AA225705	CUEDC1	chr17	55975012	-	NEMF	chr14	50262504	+
101171	STAD	TCGA-HU-A4HB-01A	JMJD1C	chr10	64936057	-	NEMF	chr14	50256061	-
95693	N/A	EC557862	NEMF	chr14	50266221	+	ANKRD11	chr16	89348653	-
64184	BRCA	TCGA-C8-A12P-01A	NEMF	chr14	50262509	-	C14orf182	chr14	50459591	-
64184	LUSC	TCGA-37-3783	NEMF	chr14	50307435	-	C14orf182	chr14	50459591	-
64184	LUSC	TCGA-37-3783	NEMF	chr14	50307436	-	C14orf182	chr14	50459591	-
64184	LUSC	TCGA-37-3783	NEMF	chr14	50312858	-	C14orf182	chr14	50459591	-
79268	BRCA	TCGA-E9-A1N9	NEMF	chr14	50295008	-	CDKL1	chr14	50808940	-
79268	BRCA	TCGA-E9-A1N9-01A	NEMF	chr14	50295009	-	CDKL1	chr14	50808940	-
100410	N/A	FN134676	NEMF	chr14	50262504	-	CNKSR2	chrX	21546641	+
98653	N/A	BC073981	NEMF	chr14	50253438	-	FN1	chr2	216292878	-
94647	N/A	BF989506	NEMF	chr14	50295816	-	FOXO3	chr6	108951529	+
89588	N/A	BQ338732	NEMF	chr14	50300162	-	GNB5	chr15	52414427	+
58605	N/A	AA541624	NEMF	chr14	50249088	-	KLHDC2	chr14	50249175	-
67809	PAAD	TCGA-LB-A7SX-01A	NEMF	chr14	50292585	-	L2HGDH	chr14	50704443	-
101171	N/A	BG878308	NEMF	chr14	50269182	-	NEMF	chr14	50295399	-
101171	N/A	BU541686	NEMF	chr14	50255863	-	NEMF	chr14	50298082	-
101171	N/A	BU685747	NEMF	chr14	50267197	+	NEMF	chr14	50255863	+
87127	N/A	DT220644	NEMF	chr14	50258087	+	NOSTRIN	chr2	169659109	+
84611	UCEC	TCGA-DI-A2QY-01A	NEMF	chr14	50269171	-	POLE2	chr14	50114078	-
77262	N/A	AX182090	NEMF	chr14	50289050	-	S100A2	chr1	153533816	+
95116	BRCA	TCGA-E2-A10A-01A	NEMF	chr14	50302450	-	SLC35F4	chr14	58091141	+
85279	BRCA	TCGA-C8-A27B-01A	NEMF	chr14	50300141	-	SOS2	chr14	50587102	-
85279	ESCA	TCGA-L5-A43I-01A	NEMF	chr14	50280706	-	SOS2	chr14	50612314	-
85279	LUAD	TCGA-MP-A4TI-01A	NEMF	chr14	50280706	-	SOS2	chr14	50587102	-
85279	LUAD	TCGA-MP-A4TI-01A	NEMF	chr14	50281472	-	SOS2	chr14	50587102	-
85279	N/A	AW581999	NEMF	chr14	50292260	+	SOS2	chr14	50685048	+
98981	N/A	BI005060	NEMF	chr14	50256016	+	ST3GAL1	chr8	134468265	+
58605	N/A	CB054263	NEMF	chr14	50289026	-	TSSK3	chr1	32826895	+
58605	PRAD	TCGA-EJ-A46G	NEMF	chr14	50255864	-	VCPKMT	chr14	50576431	-
60136	BRCA	TCGA-BH-A0C7	NEMF	chr14	50318280	-	ZNF558	chr19	8923898	-
101171	BRCA	TCGA-BH-A1FE-01A	NIN	chr14	51273455	-	NEMF	chr14	50292673	-
101171	BRCA	TCGA-AN-A0FF	SOS2	chr14	50697914	-	NEMF	chr14	50262662	-
101171	BRCA	TCGA-AN-A0FF-01A	SOS2	chr14	50697915	-	NEMF	chr14	50262662	-
101176	OV	TCGA-61-2000	ZFYVE26	chr14	68234420	-	NEMF	chr14	50252038	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type

Translation factor

pval

adj.p

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type

Translation factor

pval

adj.p

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C1510586	Autism Spectrum Disorders	1	CTD_human